[ { "title": "Structural insights into Atg10-mediated formation of the autophagy-essential Atg12-Atg5 conjugate.", "journal": "Structure (London, England : 1993)", "date": "2012", "authors": "Yamaguchi M, Noda NN, Yamamoto H, Shima T, Kumeta H, Kobashigawa Y, Akada R, Ohsumi Y, Inagaki F", "reference": { "type": "PubMed", "id": "22682742", "url": "https://pubmed.ncbi.nlm.nih.gov/22682742" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NBW4-1", "protein_name": "Neutral amino acid transporter 9", "gene_name": "SLC38A9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H0R8-1", "protein_name": "Gamma-aminobutyric acid receptor-associated protein-like 1", "gene_name": "GABARAPL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y4P8-1", "protein_name": "WD repeat domain phosphoinositide-interacting protein 2", "gene_name": "WIPI2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14457-1", "protein_name": "Beclin-1", "gene_name": "BECN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95166-1", "protein_name": "Gamma-aminobutyric acid receptor-associated protein", "gene_name": "GABARAP", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75385-1", "protein_name": "Serine/threonine-protein kinase ULK1", "gene_name": "ULK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y4P1-1", "protein_name": "Cysteine protease ATG4B", "gene_name": "ATG4B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H492-1", "protein_name": "Microtubule-associated protein 1 light chain 3 alpha", "gene_name": "MAP1LC3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q674R7-1", "protein_name": "Autophagy-related protein 9B", "gene_name": "ATG9B", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94817-1", "protein_name": "Ubiquitin-like protein ATG12", "gene_name": "ATG12", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75143-1", "protein_name": "Autophagy-related protein 13", "gene_name": "ATG13", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQL2-1", "protein_name": "Ras-related GTP-binding protein D", "gene_name": "RRAGD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HB90-1", "protein_name": "Ras-related GTP-binding protein C", "gene_name": "RRAGC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96FZ7-1", "protein_name": "Charged multivesicular body protein 6", "gene_name": "CHMP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WUX9-1", "protein_name": "Charged multivesicular body protein 7", "gene_name": "CHMP7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY43-1", "protein_name": "Charged multivesicular body protein 4a", "gene_name": "CHMP4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y3E7-1", "protein_name": "Charged multivesicular body protein 3", "gene_name": "CHMP3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43633-1", "protein_name": "Charged multivesicular body protein 2a", "gene_name": "CHMP2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQN3-1", "protein_name": "Charged multivesicular body protein 2b", "gene_name": "CHMP2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99570-1", "protein_name": "Phosphoinositide 3-kinase regulatory subunit 4", "gene_name": "PIK3R4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86TL0-1", "protein_name": "Cysteine protease ATG4D", "gene_name": "ATG4D", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92574-1", "protein_name": "Hamartin", "gene_name": "TSC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9P2Y5-1", "protein_name": "UV radiation resistance-associated gene protein", "gene_name": "UVRAG", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95352-1", "protein_name": "Ubiquitin-like modifier-activating enzyme ATG7", "gene_name": "ATG7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BSB4-1", "protein_name": "Autophagy-related protein 101", "gene_name": "ATG101", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WYN0-1", "protein_name": "Cysteine protease ATG4A", "gene_name": "ATG4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H0Y0-1", "protein_name": "Ubiquitin-like-conjugating enzyme ATG10", "gene_name": "ATG10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NT62-1", "protein_name": "Ubiquitin-like-conjugating enzyme ATG3", "gene_name": "ATG3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NCE2-1", "protein_name": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14", "gene_name": "MTMR14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z3C6-1", "protein_name": "Autophagy-related protein 9A", "gene_name": "ATG9A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96CF2-1", "protein_name": "Charged multivesicular body protein 4c", "gene_name": "CHMP4C", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VZM2-1", "protein_name": "Ras-related GTP-binding protein B", "gene_name": "RRAGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY60-1", "protein_name": "Gamma-aminobutyric acid receptor-associated protein-like 3", "gene_name": "GABARAPL3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6IAA8-1", "protein_name": "Ragulator complex protein LAMTOR1", "gene_name": "LAMTOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BVC4-1", "protein_name": "Target of rapamycin complex subunit LST8", "gene_name": "MLST8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q0VGL1-1", "protein_name": "Ragulator complex protein LAMTOR4", "gene_name": "LAMTOR4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43504-1", "protein_name": "Ragulator complex protein LAMTOR5", "gene_name": "LAMTOR5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7L523-1", "protein_name": "Ras-related GTP-binding protein A", "gene_name": "RRAGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60520-1", "protein_name": "Gamma-aminobutyric acid receptor-associated protein-like 2", "gene_name": "GABARAPL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H1Y0-1", "protein_name": "Autophagy protein 5", "gene_name": "ATG5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N122-1", "protein_name": "Regulatory-associated protein of mTOR", "gene_name": "RPTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TDY2-1", "protein_name": "RB1-inducible coiled-coil protein 1", "gene_name": "RB1CC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9C0C7-1", "protein_name": "Activating molecule in BECN1-regulated autophagy protein 1", "gene_name": "AMBRA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q676U5-1", "protein_name": "Autophagy-related protein 16-1", "gene_name": "ATG16L1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UGI9-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-3", "gene_name": "PRKAG3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42345-1", "protein_name": "Serine/threonine-protein kinase mTOR", "gene_name": "MTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BXW4-1", "protein_name": "Microtubule-associated protein 1 light chain 3 gamma", "gene_name": "MAP1LC3C", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9GZQ8-1", "protein_name": "Microtubule-associated protein 1 light chain 3 beta", "gene_name": "MAP1LC3B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63167-1", "protein_name": "Dynein light chain 1, cytoplasmic", "gene_name": "DYNLL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5MNZ6-1", "protein_name": "WD repeat domain phosphoinositide-interacting protein 3", "gene_name": "WDR45B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NEB9-1", "protein_name": "Phosphatidylinositol 3-kinase catalytic subunit type 3", "gene_name": "PIK3C3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96DT6-1", "protein_name": "Cysteine protease ATG4C", "gene_name": "ATG4C", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6ZNE5-1", "protein_name": "Beclin 1-associated autophagy-related key regulator", "gene_name": "ATG14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H444-1", "protein_name": "Charged multivesicular body protein 4b", "gene_name": "CHMP4B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96FJ2-1", "protein_name": "Dynein light chain 2, cytoplasmic", "gene_name": "DYNLL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13615-1", "protein_name": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3", "gene_name": "MTMR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15382-1", "protein_name": "GTP-binding protein Rheb", "gene_name": "RHEB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y484-1", "protein_name": "WD repeat domain phosphoinositide-interacting protein 4", "gene_name": "WDR45", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5MNZ9-1", "protein_name": "WD repeat domain phosphoinositide-interacting protein 1", "gene_name": "WIPI1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NAA4-1", "protein_name": "Protein Atg16l2", "gene_name": "ATG16L2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49815-1", "protein_name": "Tuberin", "gene_name": "TSC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54619-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-1", "gene_name": "PRKAG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43741-1", "protein_name": "5'-AMP-activated protein kinase subunit beta-2", "gene_name": "PRKAB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13131-1", "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-1", "gene_name": "PRKAA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54646-1", "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-2", "gene_name": "PRKAA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UGJ0-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-2", "gene_name": "PRKAG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y478-1", "protein_name": "5'-AMP-activated protein kinase subunit beta-1", "gene_name": "PRKAB1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.22682742", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 69 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.", "journal": "Cell", "date": "2012", "authors": "Bar-Peled L, Schweitzer LD, Zoncu R, Sabatini DM", "reference": { "type": "PubMed", "id": "22980980", "url": "https://pubmed.ncbi.nlm.nih.gov/22980980" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NBW4-1", "protein_name": "Neutral amino acid transporter 9", "gene_name": "SLC38A9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P58004-1", "protein_name": "Sestrin-2", "gene_name": "SESN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HCK5-1", "protein_name": "Protein argonaute-4", "gene_name": "AGO4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UL18-1", "protein_name": "Protein argonaute-1", "gene_name": "AGO1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UPQ9-3", "protein_name": "Trinucleotide repeat-containing gene 6B protein", "gene_name": "TNRC6B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y243-1", "protein_name": "RAC-gamma serine/threonine-protein kinase", "gene_name": "AKT3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96S15-1", "protein_name": "GATOR2 complex protein WDR24", "gene_name": "WDR24", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HCJ0-3", "protein_name": "Trinucleotide repeat-containing gene 6C protein", "gene_name": "TNRC6C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21283-1", "protein_name": "V-type proton ATPase subunit C 1", "gene_name": "ATP6V1C1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQL2-1", "protein_name": "Ras-related GTP-binding protein D", "gene_name": "RRAGD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HB90-1", "protein_name": "Ras-related GTP-binding protein C", "gene_name": "RRAGC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9P0V3-1", "protein_name": "SH3 domain-binding protein 4", "gene_name": "SH3BP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75348-1", "protein_name": "V-type proton ATPase subunit G 1", "gene_name": "ATP6V1G1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y664-1", "protein_name": "KICSTOR complex protein kaptin", "gene_name": "KPTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MD2-1", "protein_name": "KICSTOR subunit 2", "gene_name": "KICS2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12980-1", "protein_name": "GATOR1 complex protein NPRL3", "gene_name": 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"Q969R8-1", "protein_name": "KICSTOR complex protein ITFG2", "gene_name": "ITFG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VZM2-1", "protein_name": "Ras-related GTP-binding protein B", "gene_name": "RRAGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NEY4-1", "protein_name": "V-type proton ATPase subunit C 2", "gene_name": "ATP6V1C2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5T011-1", "protein_name": "KICSTOR complex protein SZT2", "gene_name": "SZT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5K8-1", "protein_name": "V-type proton ATPase subunit D", "gene_name": "ATP6V1D", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N8Y2-1", "protein_name": "V-type proton ATPase subunit d 2", "gene_name": "ATP6V0D2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15313-1", "protein_name": "V-type proton ATPase subunit B, kidney isoform", "gene_name": "ATP6V1B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6IAA8-1", "protein_name": "Ragulator 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"AGO2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42345-1", "protein_name": "Serine/threonine-protein kinase mTOR", "gene_name": "MTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31751-1", "protein_name": "RAC-beta serine/threonine-protein kinase", "gene_name": "AKT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H9G7-1", "protein_name": "Protein argonaute-3", "gene_name": "AGO3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NDV7-1", "protein_name": "Trinucleotide repeat-containing gene 6A protein", "gene_name": "TNRC6A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96A05-1", "protein_name": "V-type proton ATPase subunit E 2", "gene_name": "ATP6V1E2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TF40-1", "protein_name": "Folliculin-interacting protein 1", "gene_name": "FNIP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFG4-1", "protein_name": "Folliculin", "gene_name": "FLCN", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"gene_name": "ATP6V0C", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NXC5-1", "protein_name": "GATOR2 complex protein MIOS", "gene_name": "MIOS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61421-1", "protein_name": "V-type proton ATPase subunit d 1", "gene_name": "ATP6V0D1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95670-1", "protein_name": "V-type proton ATPase subunit G 2", "gene_name": "ATP6V1G2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36543-1", "protein_name": "V-type proton ATPase subunit E 1", "gene_name": "ATP6V1E1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38606-1", "protein_name": "V-type proton ATPase catalytic subunit A", "gene_name": "ATP6V1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99437-1", "protein_name": "V-type proton ATPase 21 kDa proteolipid subunit c''", "gene_name": "ATP6V0B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PJI9-1", "protein_name": "GATOR2 complex protein WDR59", "gene_name": "WDR59", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31946-1", "protein_name": "14-3-3 protein beta/alpha", "gene_name": "YWHAB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96B36-1", "protein_name": "Proline-rich AKT1 substrate 1", "gene_name": "AKT1S1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.22980980", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 70 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { 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"total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy.", "journal": "Nature structural & molecular biology", "date": "2013", "authors": "Otomo C, Metlagel Z, Takaesu G, Otomo T", "reference": { "type": "PubMed", "id": "23202584", "url": "https://pubmed.ncbi.nlm.nih.gov/23202584" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NBW4-1", "protein_name": "Neutral amino acid transporter 9", "gene_name": "SLC38A9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { 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[] } ] }, { "title": "Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex.", "journal": "Blood", "date": "2013", "authors": "Gao C, Dimitrov T, Yong KJ, Tatetsu H, Jeong HW, Luo HR, Bradner JE, Tenen DG, Chai L", "reference": { "type": "PubMed", "id": "23287862", "url": "https://pubmed.ncbi.nlm.nih.gov/23287862" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NBW4-1", "protein_name": "Neutral amino acid transporter 9", "gene_name": "SLC38A9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HC52-1", "protein_name": "Chromobox protein homolog 8", "gene_name": "CBX8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P28482-1", "protein_name": "Mitogen-activated protein kinase 1", "gene_name": "MAPK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15336-1", "protein_name": "Cyclic AMP-dependent transcription factor ATF-2", "gene_name": "ATF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18146-1", "protein_name": "Early growth response protein 1", "gene_name": "EGR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13330-1", "protein_name": "Metastasis-associated protein MTA1", "gene_name": "MTA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13547-1", "protein_name": "Histone deacetylase 1", "gene_name": "HDAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86YP4-1", "protein_name": "Transcriptional repressor p66-alpha", "gene_name": "GATAD2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQL2-1", "protein_name": "Ras-related GTP-binding protein D", "gene_name": "RRAGD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HB90-1", "protein_name": "Ras-related GTP-binding protein C", "gene_name": "RRAGC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P37231-1", "protein_name": "Peroxisome proliferator-activated receptor gamma", "gene_name": "PPARG", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16576-1", "protein_name": "Histone-binding protein RBBP7", "gene_name": "RBBP7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NDX5-1", "protein_name": "Polyhomeotic-like protein 3", "gene_name": "PHC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UJQ4-1", "protein_name": "Sal-like protein 4", "gene_name": "SALL4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43623-1", "protein_name": "Zinc finger protein SNAI2", "gene_name": "SNAI2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75530-1", "protein_name": "Polycomb protein EED", "gene_name": "EED", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15910-1", "protein_name": "Histone-lysine N-methyltransferase EZH2", "gene_name": "EZH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54259-1", "protein_name": "Atrophin-1", "gene_name": "ATN1", "tax_name": "Human" }, { 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"protein_name": "Ragulator complex protein LAMTOR4", "gene_name": "LAMTOR4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43504-1", "protein_name": "Ragulator complex protein LAMTOR5", "gene_name": "LAMTOR5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7L523-1", "protein_name": "Ras-related GTP-binding protein A", "gene_name": "RRAGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15379-1", "protein_name": "Histone deacetylase 3", "gene_name": "HDAC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WUI4-1", "protein_name": "Histone deacetylase 7", "gene_name": "HDAC7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQL6-1", "protein_name": "Histone deacetylase 5", "gene_name": "HDAC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IXK0-1", "protein_name": "Polyhomeotic-like protein 2", "gene_name": "PHC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N122-1", "protein_name": "Regulatory-associated protein of mTOR", "gene_name": "RPTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60341-1", "protein_name": "Lysine-specific histone demethylase 1A", "gene_name": "KDM1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42345-1", "protein_name": "Serine/threonine-protein kinase mTOR", "gene_name": "MTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95863-1", "protein_name": "Zinc finger protein SNAI1", "gene_name": "SNAI1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q03112-7", "protein_name": "Histone-lysine N-methyltransferase MECOM", "gene_name": "MECOM", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12873-1", "protein_name": "ATP-dependent chromatin remodeler CHD3", "gene_name": "CHD3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92769-1", "protein_name": "Histone deacetylase 2", "gene_name": "HDAC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95503-1", "protein_name": "Chromobox protein homolog 6", "gene_name": "CBX6", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"uniprot_canonical_ac": "Q8WXI9-1", "protein_name": "Transcriptional repressor p66-beta", "gene_name": "GATAD2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00257-1", "protein_name": "E3 SUMO-protein ligase CBX4", "gene_name": "CBX4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04637-1", "protein_name": "Cellular tumor antigen p53", "gene_name": "TP53", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.23287862", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 59 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { 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"protein_name": "Charged multivesicular body protein 7", "gene_name": "CHMP7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY43-1", "protein_name": "Charged multivesicular body protein 4a", "gene_name": "CHMP4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y3E7-1", "protein_name": "Charged multivesicular body protein 3", "gene_name": "CHMP3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43633-1", "protein_name": "Charged multivesicular body protein 2a", "gene_name": "CHMP2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQN3-1", "protein_name": "Charged multivesicular body protein 2b", "gene_name": "CHMP2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99570-1", "protein_name": "Phosphoinositide 3-kinase regulatory subunit 4", "gene_name": "PIK3R4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86TL0-1", "protein_name": "Cysteine protease ATG4D", "gene_name": "ATG4D", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92574-1", "protein_name": "Hamartin", "gene_name": "TSC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9P2Y5-1", "protein_name": "UV radiation resistance-associated gene protein", "gene_name": "UVRAG", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95352-1", "protein_name": "Ubiquitin-like modifier-activating enzyme ATG7", "gene_name": "ATG7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BSB4-1", "protein_name": "Autophagy-related protein 101", "gene_name": "ATG101", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WYN0-1", "protein_name": "Cysteine protease ATG4A", "gene_name": "ATG4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H0Y0-1", "protein_name": "Ubiquitin-like-conjugating enzyme ATG10", "gene_name": "ATG10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NT62-1", "protein_name": "Ubiquitin-like-conjugating enzyme ATG3", "gene_name": "ATG3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NCE2-1", "protein_name": "Phosphatidylinositol-3,5-bisphosphate 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protein LAMTOR4", "gene_name": "LAMTOR4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43504-1", "protein_name": "Ragulator complex protein LAMTOR5", "gene_name": "LAMTOR5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7L523-1", "protein_name": "Ras-related GTP-binding protein A", "gene_name": "RRAGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60520-1", "protein_name": "Gamma-aminobutyric acid receptor-associated protein-like 2", "gene_name": "GABARAPL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H1Y0-1", "protein_name": "Autophagy protein 5", "gene_name": "ATG5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N122-1", "protein_name": "Regulatory-associated protein of mTOR", "gene_name": "RPTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TDY2-1", "protein_name": "RB1-inducible coiled-coil protein 1", "gene_name": "RB1CC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9C0C7-1", "protein_name": "Activating molecule in BECN1-regulated 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"WD repeat domain phosphoinositide-interacting protein 3", "gene_name": "WDR45B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NEB9-1", "protein_name": "Phosphatidylinositol 3-kinase catalytic subunit type 3", "gene_name": "PIK3C3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96DT6-1", "protein_name": "Cysteine protease ATG4C", "gene_name": "ATG4C", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6ZNE5-1", "protein_name": "Beclin 1-associated autophagy-related key regulator", "gene_name": "ATG14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H444-1", "protein_name": "Charged multivesicular body protein 4b", "gene_name": "CHMP4B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96FJ2-1", "protein_name": "Dynein light chain 2, cytoplasmic", "gene_name": "DYNLL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13615-1", "protein_name": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3", "gene_name": "MTMR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15382-1", "protein_name": "GTP-binding protein Rheb", "gene_name": "RHEB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y484-1", "protein_name": "WD repeat domain phosphoinositide-interacting protein 4", "gene_name": "WDR45", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5MNZ9-1", "protein_name": "WD repeat domain phosphoinositide-interacting protein 1", "gene_name": "WIPI1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NAA4-1", "protein_name": "Protein Atg16l2", "gene_name": "ATG16L2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49815-1", "protein_name": "Tuberin", "gene_name": "TSC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54619-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-1", "gene_name": "PRKAG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43741-1", "protein_name": "5'-AMP-activated protein kinase subunit beta-2", "gene_name": "PRKAB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13131-1", "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-1", "gene_name": "PRKAA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54646-1", "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-2", "gene_name": "PRKAA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UGJ0-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-2", "gene_name": "PRKAG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y478-1", "protein_name": "5'-AMP-activated protein kinase subunit beta-1", "gene_name": "PRKAB1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.23685627", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 69 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.", "journal": "Science (New York, N.Y.)", "date": "2013", "authors": "Bar-Peled L, Chantranupong L, Cherniack AD, Chen WW, Ottina KA, Grabiner BC, Spear ED, Carter SL, Meyerson M, Sabatini DM", "reference": { "type": "PubMed", "id": "23723238", "url": "https://pubmed.ncbi.nlm.nih.gov/23723238" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NBW4-1", "protein_name": "Neutral amino acid transporter 9", "gene_name": "SLC38A9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P58004-1", "protein_name": "Sestrin-2", "gene_name": "SESN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96S15-1", "protein_name": "GATOR2 complex protein WDR24", "gene_name": "WDR24", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21283-1", "protein_name": "V-type proton ATPase subunit C 1", "gene_name": "ATP6V1C1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQL2-1", "protein_name": "Ras-related GTP-binding protein D", "gene_name": "RRAGD", 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"GATOR complex protein Iml1", "gene_name": "Iml1", "tax_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q8WTW4-1", "protein_name": "GATOR1 complex protein NPRL2", "gene_name": "NPRL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96EE3-2", "protein_name": "Nucleoporin SEH1", "gene_name": "SEH1L", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55735-1", "protein_name": "Protein SEC13 homolog", "gene_name": "SEC13", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6P5-1", "protein_name": "Sestrin-1", "gene_name": "SESN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "A6NHX0-1", "protein_name": "Cytosolic arginine sensor for mTORC1 subunit 2", "gene_name": "CASTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WTX7-1", "protein_name": "Cytosolic arginine sensor for mTORC1 subunit 1", "gene_name": "CASTOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q969R8-1", "protein_name": "KICSTOR complex protein ITFG2", "gene_name": "ITFG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VZM2-1", "protein_name": "Ras-related GTP-binding protein B", "gene_name": "RRAGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NEY4-1", "protein_name": "V-type proton ATPase subunit C 2", "gene_name": "ATP6V1C2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5T011-1", "protein_name": "KICSTOR complex protein SZT2", "gene_name": "SZT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5K8-1", "protein_name": "V-type proton ATPase subunit D", "gene_name": "ATP6V1D", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N8Y2-1", "protein_name": "V-type proton ATPase subunit d 2", "gene_name": "ATP6V0D2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15313-1", "protein_name": "V-type proton ATPase subunit B, kidney isoform", "gene_name": "ATP6V1B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6IAA8-1", "protein_name": "Ragulator complex protein LAMTOR1", "gene_name": "LAMTOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"Folliculin-interacting protein 1", "gene_name": "FNIP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFG4-1", "protein_name": "Folliculin", "gene_name": "FLCN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9P278-1", "protein_name": "Folliculin-interacting protein 2", "gene_name": "FNIP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NHE4-1", "protein_name": "V-type proton ATPase subunit e 2", "gene_name": "ATP6V0E2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q1RMZ1-1", "protein_name": "S-adenosylmethionine sensor upstream of mTORC1", "gene_name": "SAMTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75140-10", "protein_name": "GATOR1 complex protein DEPDC5", "gene_name": "DEPDC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15382-1", "protein_name": "GTP-binding protein Rheb", "gene_name": "RHEB", 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"gene_name": "PIK3R4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86TL0-1", "protein_name": "Cysteine protease ATG4D", "gene_name": "ATG4D", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92574-1", "protein_name": "Hamartin", "gene_name": "TSC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9P2Y5-1", "protein_name": "UV radiation resistance-associated gene protein", "gene_name": "UVRAG", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95352-1", "protein_name": "Ubiquitin-like modifier-activating enzyme ATG7", "gene_name": "ATG7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BSB4-1", "protein_name": "Autophagy-related protein 101", "gene_name": "ATG101", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WYN0-1", "protein_name": "Cysteine protease ATG4A", "gene_name": "ATG4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H0Y0-1", "protein_name": "Ubiquitin-like-conjugating enzyme ATG10", "gene_name": "ATG10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NT62-1", "protein_name": "Ubiquitin-like-conjugating enzyme ATG3", "gene_name": "ATG3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NCE2-1", "protein_name": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14", "gene_name": "MTMR14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z3C6-1", "protein_name": "Autophagy-related protein 9A", "gene_name": "ATG9A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96CF2-1", "protein_name": "Charged multivesicular body protein 4c", "gene_name": "CHMP4C", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VZM2-1", "protein_name": "Ras-related GTP-binding protein B", "gene_name": "RRAGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY60-1", "protein_name": "Gamma-aminobutyric acid receptor-associated protein-like 3", "gene_name": "GABARAPL3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6IAA8-1", "protein_name": "Ragulator complex protein LAMTOR1", "gene_name": "LAMTOR1", "tax_name": 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"uniprot_canonical_ac": "Q8TDY2-1", "protein_name": "RB1-inducible coiled-coil protein 1", "gene_name": "RB1CC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9C0C7-1", "protein_name": "Activating molecule in BECN1-regulated autophagy protein 1", "gene_name": "AMBRA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q676U5-1", "protein_name": "Autophagy-related protein 16-1", "gene_name": "ATG16L1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UGI9-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-3", "gene_name": "PRKAG3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42345-1", "protein_name": "Serine/threonine-protein kinase mTOR", "gene_name": "MTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BXW4-1", "protein_name": "Microtubule-associated protein 1 light chain 3 gamma", "gene_name": "MAP1LC3C", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9GZQ8-1", "protein_name": "Microtubule-associated protein 1 light chain 3 beta", "gene_name": "MAP1LC3B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63167-1", "protein_name": "Dynein light chain 1, cytoplasmic", "gene_name": "DYNLL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5MNZ6-1", "protein_name": "WD repeat domain phosphoinositide-interacting protein 3", "gene_name": "WDR45B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NEB9-1", "protein_name": "Phosphatidylinositol 3-kinase catalytic subunit type 3", "gene_name": "PIK3C3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96DT6-1", "protein_name": "Cysteine protease ATG4C", "gene_name": "ATG4C", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6ZNE5-1", "protein_name": "Beclin 1-associated autophagy-related key regulator", "gene_name": "ATG14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H444-1", "protein_name": "Charged multivesicular body protein 4b", "gene_name": "CHMP4B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96FJ2-1", "protein_name": "Dynein light chain 2, cytoplasmic", "gene_name": "DYNLL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13615-1", "protein_name": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3", "gene_name": "MTMR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15382-1", "protein_name": "GTP-binding protein Rheb", "gene_name": "RHEB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y484-1", "protein_name": "WD repeat domain phosphoinositide-interacting protein 4", "gene_name": "WDR45", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5MNZ9-1", "protein_name": "WD repeat domain phosphoinositide-interacting protein 1", "gene_name": "WIPI1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NAA4-1", "protein_name": "Protein Atg16l2", "gene_name": "ATG16L2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49815-1", "protein_name": "Tuberin", "gene_name": "TSC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54619-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-1", "gene_name": "PRKAG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43741-1", "protein_name": "5'-AMP-activated protein kinase subunit beta-2", "gene_name": "PRKAB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13131-1", "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-1", "gene_name": "PRKAA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54646-1", "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-2", "gene_name": "PRKAA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UGJ0-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-2", "gene_name": "PRKAG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y478-1", "protein_name": "5'-AMP-activated protein kinase subunit beta-1", "gene_name": "PRKAB1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.23727157", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 69 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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[] } ] }, { "title": "Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells.", "journal": "Nucleic acids research", "date": "2013", "authors": "Menendez D, Nguyen TA, Freudenberg JM, Mathew VJ, Anderson CW, Jothi R, Resnick MA", "reference": { "type": "PubMed", "id": "23775793", "url": "https://pubmed.ncbi.nlm.nih.gov/23775793" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NBW4-1", "protein_name": "Neutral amino acid transporter 9", "gene_name": "SLC38A9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P58004-1", "protein_name": "Sestrin-2", "gene_name": "SESN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P58005-1", "protein_name": "Sestrin-3", "gene_name": "SESN3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43819-1", "protein_name": "Cytochrome c oxidase assembly factor SCO2", "gene_name": "SCO2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HCK5-1", "protein_name": "Protein argonaute-4", "gene_name": "AGO4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UL18-1", "protein_name": "Protein argonaute-1", "gene_name": "AGO1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UPQ9-3", "protein_name": "Trinucleotide repeat-containing gene 6B protein", "gene_name": "TNRC6B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y243-1", "protein_name": "RAC-gamma serine/threonine-protein kinase", "gene_name": "AKT3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HCJ0-3", "protein_name": "Trinucleotide repeat-containing gene 6C protein", "gene_name": "TNRC6C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P99999-1", "protein_name": "Cytochrome c", "gene_name": "CYCS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQL2-1", "protein_name": "Ras-related GTP-binding protein D", "gene_name": 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"tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N122-1", "protein_name": "Regulatory-associated protein of mTOR", "gene_name": "RPTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31749-1", "protein_name": "RAC-alpha serine/threonine-protein kinase", "gene_name": "AKT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UGI9-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-3", "gene_name": "PRKAG3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UKV8-1", "protein_name": "Protein argonaute-2", "gene_name": "AGO2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42345-1", "protein_name": "Serine/threonine-protein kinase mTOR", "gene_name": "MTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31751-1", "protein_name": "RAC-beta serine/threonine-protein kinase", "gene_name": "AKT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06830-1", "protein_name": "Peroxiredoxin-1", "gene_name": "PRDX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H9G7-1", "protein_name": "Protein argonaute-3", "gene_name": "AGO3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NDV7-1", "protein_name": "Trinucleotide repeat-containing gene 6A protein", "gene_name": "TNRC6A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00395-1", "protein_name": "Cytochrome c oxidase subunit 1", "gene_name": "MT-CO1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00414-1", "protein_name": "Cytochrome c oxidase subunit 3", "gene_name": "MT-CO3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96KJ9-1", "protein_name": "Cytochrome c oxidase subunit 4 isoform 2, mitochondrial", "gene_name": "COX4I2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14548-1", "protein_name": "Cytochrome c oxidase subunit 7A2-like, mitochondrial", "gene_name": "COX7A2L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q02221-1", "protein_name": "Cytochrome c oxidase subunit 6A2, mitochondrial", "gene_name": "COX6A2", "tax_name": 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"uniprot_canonical_ac": "P60484-1", "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN", "gene_name": "PTEN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HCE1-1", "protein_name": "RNA helicase MOV-10", "gene_name": "MOV10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15382-1", "protein_name": "GTP-binding protein Rheb", "gene_name": "RHEB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NX09-1", "protein_name": "DNA damage-inducible transcript 4 protein", "gene_name": "DDIT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49815-1", "protein_name": "Tuberin", "gene_name": "TSC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62258-1", "protein_name": "14-3-3 protein epsilon", "gene_name": "YWHAE", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"gene_name": "MAP1LC3B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63167-1", "protein_name": "Dynein light chain 1, cytoplasmic", "gene_name": "DYNLL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5MNZ6-1", "protein_name": "WD repeat domain phosphoinositide-interacting protein 3", "gene_name": "WDR45B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NEB9-1", "protein_name": "Phosphatidylinositol 3-kinase catalytic subunit type 3", "gene_name": "PIK3C3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96DT6-1", "protein_name": "Cysteine protease ATG4C", "gene_name": "ATG4C", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6ZNE5-1", "protein_name": "Beclin 1-associated autophagy-related key regulator", "gene_name": "ATG14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H444-1", "protein_name": "Charged multivesicular body protein 4b", "gene_name": "CHMP4B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex 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[] } ] }, { "title": "Glucose-6-phosphate dehydrogenase: a biomarker and potential therapeutic target for cancer.", "journal": "Anti-cancer agents in medicinal chemistry", "date": "2014", "authors": "Zhang C, Zhang Z, Zhu Y, Qin S", "reference": { "type": "PubMed", "id": "24066844", "url": "https://pubmed.ncbi.nlm.nih.gov/24066844" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NBW4-1", "protein_name": "Neutral amino acid transporter 9", "gene_name": "SLC38A9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P58004-1", "protein_name": "Sestrin-2", "gene_name": "SESN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P58005-1", "protein_name": "Sestrin-3", "gene_name": "SESN3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43819-1", "protein_name": "Cytochrome c oxidase assembly factor SCO2", "gene_name": 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"protein_name": "Cytochrome c oxidase subunit 5B, mitochondrial", "gene_name": "COX5B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60484-1", "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN", "gene_name": "PTEN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HCE1-1", "protein_name": "RNA helicase MOV-10", "gene_name": "MOV10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15382-1", "protein_name": "GTP-binding protein Rheb", "gene_name": "RHEB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NX09-1", "protein_name": "DNA damage-inducible transcript 4 protein", "gene_name": "DDIT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49815-1", "protein_name": "Tuberin", "gene_name": "TSC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62258-1", "protein_name": "14-3-3 protein epsilon", "gene_name": "YWHAE", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63104-1", "protein_name": "14-3-3 protein zeta/delta", "gene_name": "YWHAZ", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54619-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-1", "gene_name": "PRKAG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04917-1", "protein_name": "14-3-3 protein eta", "gene_name": "YWHAH", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43741-1", "protein_name": "5'-AMP-activated protein kinase subunit beta-2", "gene_name": "PRKAB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31946-1", "protein_name": "14-3-3 protein beta/alpha", "gene_name": "YWHAB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13131-1", "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-1", "gene_name": "PRKAA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27348-1", "protein_name": "14-3-3 protein 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"reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.24366874", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 81 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "TIGAR, TIGAR, burning bright.", "journal": "Cancer & metabolism", "date": "2014", "authors": "Lee P, Vousden KH, Cheung EC", "reference": { "type": "PubMed", "id": "24383451", "url": "https://pubmed.ncbi.nlm.nih.gov/24383451" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NBW4-1", "protein_name": "Neutral amino acid transporter 9", "gene_name": "SLC38A9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P58004-1", "protein_name": "Sestrin-2", "gene_name": "SESN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P58005-1", "protein_name": "Sestrin-3", "gene_name": "SESN3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43819-1", "protein_name": "Cytochrome c oxidase assembly factor SCO2", "gene_name": "SCO2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HCK5-1", "protein_name": "Protein argonaute-4", "gene_name": "AGO4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UL18-1", "protein_name": "Protein argonaute-1", "gene_name": "AGO1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UPQ9-3", "protein_name": "Trinucleotide repeat-containing gene 6B protein", "gene_name": "TNRC6B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y243-1", "protein_name": "RAC-gamma serine/threonine-protein kinase", "gene_name": "AKT3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HCJ0-3", "protein_name": "Trinucleotide repeat-containing gene 6C protein", "gene_name": "TNRC6C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P99999-1", "protein_name": "Cytochrome c", "gene_name": "CYCS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQL2-1", "protein_name": "Ras-related GTP-binding protein D", "gene_name": "RRAGD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HB90-1", "protein_name": "Ras-related GTP-binding protein C", "gene_name": "RRAGC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20674-1", "protein_name": "Cytochrome c oxidase subunit 5A, mitochondrial", "gene_name": "COX5A", "tax_name": "Human" }, { 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"uniprot_canonical_ac": "O00483-1", "protein_name": "Cytochrome c oxidase subunit FA4", "gene_name": "COXFA4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7LG56-1", "protein_name": "Ribonucleoside-diphosphate reductase subunit M2 B", "gene_name": "RRM2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92574-1", "protein_name": "Hamartin", "gene_name": "TSC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H3D4-1", "protein_name": "Tumor protein 63", "gene_name": "TP63", "tax_name": "Human" }, { "uniprot_canonical_ac": "P10599-1", "protein_name": "Thioredoxin", "gene_name": "TXN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14406-1", "protein_name": "Cytochrome c oxidase subunit 7A2, mitochondrial", "gene_name": "COX7A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24310-1", "protein_name": "Cytochrome c oxidase subunit 7A1, mitochondrial", "gene_name": "COX7A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VZM2-1", "protein_name": "Ras-related 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"tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BVC4-1", "protein_name": "Target of rapamycin complex subunit LST8", "gene_name": "MLST8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q0VGL1-1", "protein_name": "Ragulator complex protein LAMTOR4", "gene_name": "LAMTOR4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43504-1", "protein_name": "Ragulator complex protein LAMTOR5", "gene_name": "LAMTOR5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7L523-1", "protein_name": "Ras-related GTP-binding protein A", "gene_name": "RRAGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31947-1", "protein_name": "14-3-3 protein sigma", "gene_name": "SFN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N122-1", "protein_name": "Regulatory-associated protein of mTOR", "gene_name": "RPTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31749-1", "protein_name": "RAC-alpha serine/threonine-protein kinase", "gene_name": "AKT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UGI9-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-3", "gene_name": "PRKAG3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UKV8-1", "protein_name": "Protein argonaute-2", "gene_name": "AGO2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42345-1", "protein_name": "Serine/threonine-protein kinase mTOR", "gene_name": "MTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31751-1", "protein_name": "RAC-beta serine/threonine-protein kinase", "gene_name": "AKT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06830-1", "protein_name": "Peroxiredoxin-1", "gene_name": "PRDX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H9G7-1", "protein_name": "Protein argonaute-3", "gene_name": "AGO3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NDV7-1", "protein_name": "Trinucleotide repeat-containing gene 6A protein", "gene_name": "TNRC6A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00395-1", "protein_name": 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"count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": 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"uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94776-1", "protein_name": "Metastasis-associated protein MTA2", "gene_name": "MTA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BTC8-1", "protein_name": "Metastasis-associated protein MTA3", "gene_name": "MTA3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15382-1", "protein_name": "GTP-binding protein Rheb", "gene_name": "RHEB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UKL0-1", "protein_name": "REST corepressor 1", "gene_name": "RCOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y466-1", "protein_name": "Nuclear receptor subfamily 2 group E member 1", "gene_name": "NR2E1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27361-1", "protein_name": "Mitogen-activated protein kinase 3", "gene_name": "MAPK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NX09-1", "protein_name": "DNA damage-inducible transcript 4 protein", "gene_name": "DDIT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H063-1", "protein_name": "Repressor of RNA polymerase III transcription MAF1 homolog", "gene_name": "MAF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15022-1", "protein_name": "Polycomb protein SUZ12", "gene_name": "SUZ12", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13127-1", "protein_name": "RE1-silencing transcription factor", "gene_name": "REST", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05412-1", "protein_name": "Transcription factor Jun", "gene_name": "JUN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49815-1", "protein_name": "Tuberin", "gene_name": "TSC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62258-1", "protein_name": "14-3-3 protein epsilon", "gene_name": "YWHAE", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WXI9-1", "protein_name": "Transcriptional repressor p66-beta", "gene_name": "GATAD2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63104-1", "protein_name": "14-3-3 protein zeta/delta", "gene_name": "YWHAZ", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54619-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-1", "gene_name": "PRKAG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04917-1", "protein_name": "14-3-3 protein eta", "gene_name": "YWHAH", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00257-1", "protein_name": "E3 SUMO-protein ligase CBX4", "gene_name": "CBX4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43741-1", "protein_name": "5'-AMP-activated protein kinase subunit beta-2", "gene_name": "PRKAB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31946-1", "protein_name": "14-3-3 protein beta/alpha", "gene_name": "YWHAB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13131-1", "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-1", "gene_name": "PRKAA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27348-1", "protein_name": "14-3-3 protein theta", "gene_name": "YWHAQ", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54646-1", "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-2", "gene_name": "PRKAA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61981-1", "protein_name": "14-3-3 protein gamma", "gene_name": "YWHAG", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UGJ0-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-2", "gene_name": "PRKAG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y478-1", "protein_name": "5'-AMP-activated protein kinase subunit beta-1", "gene_name": "PRKAB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04637-1", "protein_name": "Cellular tumor antigen p53", "gene_name": "TP53", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.24718924", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 125 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3.", "journal": "Nature cell biology", "date": "2014", "authors": "Nath S, Dancourt J, Shteyn V, Puente G, Fong WM, Nag S, Bewersdorf J, Yamamoto A, Antonny B, Melia TJ", "reference": { "type": "PubMed", "id": "24747438", "url": "https://pubmed.ncbi.nlm.nih.gov/24747438" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NBW4-1", "protein_name": "Neutral amino acid transporter 9", "gene_name": "SLC38A9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H0R8-1", "protein_name": "Gamma-aminobutyric acid receptor-associated protein-like 1", "gene_name": "GABARAPL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y4P8-1", "protein_name": "WD repeat domain phosphoinositide-interacting protein 2", "gene_name": "WIPI2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14457-1", "protein_name": "Beclin-1", "gene_name": "BECN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95166-1", "protein_name": "Gamma-aminobutyric acid receptor-associated protein", "gene_name": "GABARAP", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75385-1", "protein_name": "Serine/threonine-protein kinase ULK1", "gene_name": "ULK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y4P1-1", "protein_name": "Cysteine protease ATG4B", "gene_name": "ATG4B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H492-1", "protein_name": "Microtubule-associated protein 1 light chain 3 alpha", "gene_name": "MAP1LC3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q674R7-1", "protein_name": "Autophagy-related protein 9B", "gene_name": "ATG9B", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94817-1", "protein_name": "Ubiquitin-like protein ATG12", "gene_name": "ATG12", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75143-1", "protein_name": "Autophagy-related protein 13", "gene_name": "ATG13", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQL2-1", "protein_name": "Ras-related GTP-binding protein D", "gene_name": "RRAGD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HB90-1", "protein_name": "Ras-related GTP-binding protein C", "gene_name": "RRAGC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96FZ7-1", "protein_name": "Charged multivesicular body protein 6", "gene_name": "CHMP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WUX9-1", "protein_name": "Charged multivesicular body protein 7", "gene_name": "CHMP7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY43-1", "protein_name": "Charged multivesicular body protein 4a", "gene_name": "CHMP4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y3E7-1", "protein_name": "Charged multivesicular body protein 3", "gene_name": "CHMP3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43633-1", "protein_name": "Charged multivesicular body protein 2a", "gene_name": "CHMP2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQN3-1", "protein_name": "Charged multivesicular body protein 2b", "gene_name": "CHMP2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99570-1", "protein_name": "Phosphoinositide 3-kinase regulatory subunit 4", "gene_name": "PIK3R4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86TL0-1", "protein_name": "Cysteine protease ATG4D", "gene_name": "ATG4D", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92574-1", "protein_name": "Hamartin", "gene_name": "TSC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9P2Y5-1", "protein_name": "UV radiation resistance-associated gene protein", "gene_name": "UVRAG", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95352-1", "protein_name": "Ubiquitin-like modifier-activating enzyme ATG7", "gene_name": "ATG7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BSB4-1", "protein_name": "Autophagy-related protein 101", "gene_name": "ATG101", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WYN0-1", "protein_name": "Cysteine protease ATG4A", "gene_name": "ATG4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H0Y0-1", "protein_name": "Ubiquitin-like-conjugating enzyme ATG10", "gene_name": "ATG10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NT62-1", "protein_name": "Ubiquitin-like-conjugating enzyme ATG3", "gene_name": "ATG3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NCE2-1", "protein_name": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14", "gene_name": "MTMR14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7Z3C6-1", "protein_name": "Autophagy-related protein 9A", "gene_name": "ATG9A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96CF2-1", "protein_name": "Charged multivesicular body protein 4c", "gene_name": "CHMP4C", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VZM2-1", "protein_name": "Ras-related GTP-binding protein B", "gene_name": "RRAGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY60-1", "protein_name": "Gamma-aminobutyric acid receptor-associated protein-like 3", "gene_name": "GABARAPL3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6IAA8-1", "protein_name": "Ragulator complex protein LAMTOR1", "gene_name": "LAMTOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BVC4-1", "protein_name": "Target of rapamycin complex subunit LST8", "gene_name": "MLST8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q0VGL1-1", "protein_name": "Ragulator complex protein LAMTOR4", "gene_name": "LAMTOR4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43504-1", "protein_name": "Ragulator complex protein LAMTOR5", "gene_name": "LAMTOR5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7L523-1", "protein_name": "Ras-related GTP-binding protein A", "gene_name": "RRAGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60520-1", "protein_name": "Gamma-aminobutyric acid receptor-associated protein-like 2", "gene_name": "GABARAPL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H1Y0-1", "protein_name": "Autophagy protein 5", "gene_name": "ATG5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N122-1", "protein_name": "Regulatory-associated protein of mTOR", "gene_name": "RPTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TDY2-1", "protein_name": "RB1-inducible coiled-coil protein 1", "gene_name": "RB1CC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9C0C7-1", "protein_name": "Activating molecule in BECN1-regulated autophagy protein 1", "gene_name": "AMBRA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q676U5-1", "protein_name": "Autophagy-related protein 16-1", "gene_name": "ATG16L1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UGI9-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-3", "gene_name": "PRKAG3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42345-1", "protein_name": "Serine/threonine-protein kinase mTOR", "gene_name": "MTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BXW4-1", "protein_name": "Microtubule-associated protein 1 light chain 3 gamma", "gene_name": "MAP1LC3C", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9GZQ8-1", "protein_name": "Microtubule-associated protein 1 light chain 3 beta", "gene_name": "MAP1LC3B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63167-1", "protein_name": "Dynein light chain 1, cytoplasmic", "gene_name": "DYNLL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9CPX6-1", "protein_name": "Ubiquitin-like-conjugating enzyme ATG3", "gene_name": "Atg3", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q5MNZ6-1", "protein_name": "WD repeat domain phosphoinositide-interacting protein 3", "gene_name": "WDR45B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NEB9-1", "protein_name": "Phosphatidylinositol 3-kinase catalytic subunit type 3", "gene_name": "PIK3C3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96DT6-1", "protein_name": "Cysteine protease ATG4C", "gene_name": "ATG4C", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6ZNE5-1", "protein_name": "Beclin 1-associated autophagy-related key regulator", "gene_name": "ATG14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H444-1", "protein_name": "Charged multivesicular body protein 4b", "gene_name": "CHMP4B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96FJ2-1", "protein_name": "Dynein light chain 2, cytoplasmic", "gene_name": "DYNLL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13615-1", "protein_name": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3", "gene_name": "MTMR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15382-1", "protein_name": "GTP-binding protein Rheb", "gene_name": "RHEB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y484-1", "protein_name": "WD repeat domain phosphoinositide-interacting protein 4", "gene_name": "WDR45", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5MNZ9-1", "protein_name": "WD repeat domain phosphoinositide-interacting protein 1", "gene_name": "WIPI1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NAA4-1", "protein_name": "Protein Atg16l2", "gene_name": "ATG16L2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49815-1", "protein_name": "Tuberin", "gene_name": "TSC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54619-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-1", "gene_name": "PRKAG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43741-1", "protein_name": "5'-AMP-activated protein kinase subunit beta-2", "gene_name": "PRKAB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13131-1", "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-1", "gene_name": "PRKAA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54646-1", "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-2", "gene_name": "PRKAA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UGJ0-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-2", "gene_name": "PRKAG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y478-1", "protein_name": "5'-AMP-activated protein kinase subunit beta-1", "gene_name": "PRKAB1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 11, "end_pos": 11, "sequence_org": "K", "sequence_mut": "D", "comment": "Eliminates lipidation. Does not affect the ATG3:GABARAPL1 intermediate.", "evidence": [ { "database": "UniProtKB", "id": "Q9CPX6", "url": "https://www.uniprot.org/uniprotkb/Q9CPX6" }, { "database": "PubMed", "id": "24747438", "url": "https://pubmed.ncbi.nlm.nih.gov/24747438" } ], "uniprot_canonical_ac": "Q9CPX6-1" }, { "start_pos": 11, "end_pos": 11, "sequence_org": "K", "sequence_mut": "L", "comment": "Does not affect GABARAPL1 lipdation. Rescues MAP1LC3B lipidation when transfected in cell lacking ATG3.", "evidence": [ { "database": "UniProtKB", "id": "Q9CPX6", "url": "https://www.uniprot.org/uniprotkb/Q9CPX6" }, { "database": "PubMed", "id": "24747438", "url": "https://pubmed.ncbi.nlm.nih.gov/24747438" } ], "uniprot_canonical_ac": "Q9CPX6-1" }, { "start_pos": 11, "end_pos": 11, "sequence_org": "K", "sequence_mut": "R", "comment": "Rescues MAP1LC3B lipidation when transfected in cell lacking ATG3.", "evidence": [ { "database": "UniProtKB", "id": "Q9CPX6", "url": "https://www.uniprot.org/uniprotkb/Q9CPX6" }, { "database": "PubMed", "id": "24747438", "url": "https://pubmed.ncbi.nlm.nih.gov/24747438" } ], "uniprot_canonical_ac": "Q9CPX6-1" }, { "start_pos": 11, "end_pos": 11, "sequence_org": "K", "sequence_mut": "W", "comment": "Rescues MAP1LC3B lipidation when transfected in cell lacking ATG3.", "evidence": [ { "database": "UniProtKB", "id": "Q9CPX6", "url": "https://www.uniprot.org/uniprotkb/Q9CPX6" }, { "database": "PubMed", "id": "24747438", "url": "https://pubmed.ncbi.nlm.nih.gov/24747438" } ], "uniprot_canonical_ac": "Q9CPX6-1" }, { "start_pos": 15, "end_pos": 15, "sequence_org": "V", "sequence_mut": "K", "comment": "Destroys the amphipathic character and eliminates lipidation activity. Does not affect the ATG3:GABARAPL1 intermediate.", "evidence": [ { "database": "UniProtKB", "id": "Q9CPX6", "url": "https://www.uniprot.org/uniprotkb/Q9CPX6" }, { "database": "PubMed", "id": "24747438", "url": "https://pubmed.ncbi.nlm.nih.gov/24747438" } ], "uniprot_canonical_ac": "Q9CPX6-1" }, { "start_pos": 19, "end_pos": 19, "sequence_org": "L", "sequence_mut": "K", "comment": "Destroys the amphipathic character and eliminates lipidation activity. Does not affect the ATG3:GABARAPL1 intermediate.", "evidence": [ { "database": "UniProtKB", "id": "Q9CPX6", "url": "https://www.uniprot.org/uniprotkb/Q9CPX6" }, { "database": "PubMed", "id": "24747438", "url": "https://pubmed.ncbi.nlm.nih.gov/24747438" } ], "uniprot_canonical_ac": "Q9CPX6-1" }, { "start_pos": 4, "end_pos": 4, "sequence_org": "V", "sequence_mut": "K", "comment": "Reduces the amount of hydrophobic surface area available to partition into a bilayer. Does not affect the ATG3:GABARAPL1 intermediate. Rescues MAP1LC3B lipidation when transfected in cell lacking ATG3.", "evidence": [ { "database": "UniProtKB", "id": "Q9CPX6", "url": "https://www.uniprot.org/uniprotkb/Q9CPX6" }, { "database": "PubMed", "id": "24747438", "url": "https://pubmed.ncbi.nlm.nih.gov/24747438" } ], "uniprot_canonical_ac": "Q9CPX6-1" }, { "start_pos": 5, "end_pos": 5, "sequence_org": "I", "sequence_mut": "K", "comment": "Reduces the amount of hydrophobic surface area available to partition into a bilayer. Does not affect the ATG3:GABARAPL1 intermediate.", "evidence": [ { "database": "UniProtKB", "id": "Q9CPX6", "url": "https://www.uniprot.org/uniprotkb/Q9CPX6" }, { "database": "PubMed", "id": "24747438", "url": "https://pubmed.ncbi.nlm.nih.gov/24747438" } ], "uniprot_canonical_ac": "Q9CPX6-1" }, { "start_pos": 8, "end_pos": 8, "sequence_org": "V", "sequence_mut": "D", "comment": "Destroys the amphipathic character and eliminates lipidation activity. Does not affect the ATG3:GABARAPL1 intermediate.", "evidence": [ { "database": "UniProtKB", "id": "Q9CPX6", "url": "https://www.uniprot.org/uniprotkb/Q9CPX6" }, { "database": "PubMed", "id": "24747438", "url": "https://pubmed.ncbi.nlm.nih.gov/24747438" } ], "uniprot_canonical_ac": "Q9CPX6-1" }, { "start_pos": 9, "end_pos": 9, "sequence_org": "K", "sequence_mut": "D", "comment": "Eliminates lipidation. 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"n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1.", "journal": "Molecular cell", "date": "2014", "authors": "Dooley HC, Razi M, Polson HE, Girardin SE, Wilson MI, Tooze SA", 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"uniprot_canonical_ac": "Q99437-1", "protein_name": "V-type proton ATPase 21 kDa proteolipid subunit c''", "gene_name": "ATP6V0B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PJI9-1", "protein_name": "GATOR2 complex protein WDR59", "gene_name": "WDR59", "tax_name": "Human" }, { "uniprot_canonical_ac": "P58006-1", "protein_name": "Sestrin-1", "gene_name": "Sesn1", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q99K70-1", "protein_name": "Ras-related GTP-binding protein C", "gene_name": "Rragc", "tax_name": "Mouse" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 419, "end_pos": 419, "sequence_org": "R", "sequence_mut": "A", "comment": "Unable to inhibit TORC1 signaling; when associated with A-422 and A-426.", "evidence": [ { 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.", "journal": "Cell reports", "date": 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protein B", "gene_name": "RRAGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NEY4-1", "protein_name": "V-type proton ATPase subunit C 2", "gene_name": "ATP6V1C2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5T011-1", "protein_name": "KICSTOR complex protein SZT2", "gene_name": "SZT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5K8-1", "protein_name": "V-type proton ATPase subunit D", "gene_name": "ATP6V1D", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N8Y2-1", "protein_name": "V-type proton ATPase subunit d 2", "gene_name": "ATP6V0D2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15313-1", "protein_name": "V-type proton ATPase subunit B, kidney isoform", "gene_name": "ATP6V1B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6IAA8-1", "protein_name": "Ragulator complex protein LAMTOR1", "gene_name": "LAMTOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BVC4-1", "protein_name": "Target of rapamycin complex subunit LST8", "gene_name": "MLST8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q0VGL1-1", "protein_name": "Ragulator complex protein LAMTOR4", "gene_name": "LAMTOR4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43504-1", "protein_name": "Ragulator complex protein LAMTOR5", "gene_name": "LAMTOR5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7L523-1", "protein_name": "Ras-related GTP-binding protein A", "gene_name": "RRAGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N122-1", "protein_name": "Regulatory-associated protein of mTOR", "gene_name": "RPTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42345-1", "protein_name": "Serine/threonine-protein kinase mTOR", "gene_name": "MTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96A05-1", "protein_name": "V-type proton ATPase subunit E 2", "gene_name": "ATP6V1E2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TF40-1", "protein_name": "Folliculin-interacting protein 1", "gene_name": "FNIP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFG4-1", "protein_name": "Folliculin", "gene_name": "FLCN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9P278-1", "protein_name": "Folliculin-interacting protein 2", "gene_name": "FNIP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NHE4-1", "protein_name": "V-type proton ATPase subunit e 2", "gene_name": "ATP6V0E2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q1RMZ1-1", "protein_name": "S-adenosylmethionine sensor upstream of mTORC1", "gene_name": "SAMTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75140-10", "protein_name": "GATOR1 complex protein DEPDC5", "gene_name": "DEPDC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15382-1", "protein_name": "GTP-binding protein Rheb", "gene_name": "RHEB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21281-1", "protein_name": "V-type proton ATPase subunit B, brain isoform", "gene_name": "ATP6V1B2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UI12-1", "protein_name": "V-type proton ATPase subunit H", "gene_name": "ATP6V1H", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13488-1", "protein_name": "V-type proton ATPase 116 kDa subunit a 3", "gene_name": "TCIRG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15342-1", "protein_name": "V-type proton ATPase subunit e 1", "gene_name": "ATP6V0E1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16864-1", "protein_name": "V-type proton ATPase subunit F", "gene_name": "ATP6V1F", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96LB4-1", "protein_name": "V-type proton ATPase subunit G 3", "gene_name": "ATP6V1G3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27449-1", "protein_name": "V-type proton ATPase 16 kDa proteolipid subunit c", "gene_name": "ATP6V0C", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NXC5-1", "protein_name": "GATOR2 complex protein MIOS", "gene_name": "MIOS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61421-1", "protein_name": "V-type proton ATPase subunit d 1", "gene_name": "ATP6V0D1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95670-1", "protein_name": "V-type proton ATPase subunit G 2", "gene_name": "ATP6V1G2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36543-1", "protein_name": "V-type proton ATPase subunit E 1", "gene_name": "ATP6V1E1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38606-1", "protein_name": "V-type proton ATPase catalytic subunit A", "gene_name": "ATP6V1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99437-1", "protein_name": "V-type proton ATPase 21 kDa proteolipid subunit c''", "gene_name": "ATP6V0B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PJI9-1", "protein_name": "GATOR2 complex protein WDR59", "gene_name": "WDR59", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.25263562", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 56 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Sestrins inhibit mTORC1 kinase activation through the GATOR complex.", "journal": "Cell reports", "date": "2014", "authors": "Parmigiani A, Nourbakhsh A, Ding B, Wang W, Kim YC, Akopiants K, Guan KL, Karin M, Budanov AV", "reference": { "type": "PubMed", "id": "25457612", "url": "https://pubmed.ncbi.nlm.nih.gov/25457612" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NBW4-1", "protein_name": "Neutral amino acid transporter 9", "gene_name": "SLC38A9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P58004-1", "protein_name": "Sestrin-2", "gene_name": "SESN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96S15-1", "protein_name": "GATOR2 complex protein WDR24", "gene_name": "WDR24", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21283-1", "protein_name": "V-type proton ATPase subunit C 1", "gene_name": "ATP6V1C1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQL2-1", "protein_name": "Ras-related GTP-binding protein D", "gene_name": "RRAGD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HB90-1", "protein_name": "Ras-related GTP-binding protein C", "gene_name": "RRAGC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9P0V3-1", "protein_name": "SH3 domain-binding protein 4", "gene_name": "SH3BP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75348-1", "protein_name": "V-type proton ATPase subunit G 1", "gene_name": "ATP6V1G1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y664-1", "protein_name": "KICSTOR complex protein kaptin", "gene_name": "KPTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MD2-1", "protein_name": "KICSTOR subunit 2", "gene_name": "KICS2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12980-1", "protein_name": "GATOR1 complex protein NPRL3", "gene_name": "NPRL3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WTW4-1", "protein_name": "GATOR1 complex protein NPRL2", "gene_name": "NPRL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96EE3-2", "protein_name": "Nucleoporin SEH1", "gene_name": "SEH1L", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55735-1", "protein_name": "Protein SEC13 homolog", "gene_name": "SEC13", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6P5-1", "protein_name": "Sestrin-1", "gene_name": "SESN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "A6NHX0-1", "protein_name": "Cytosolic arginine sensor for mTORC1 subunit 2", "gene_name": "CASTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WTX7-1", "protein_name": "Cytosolic arginine sensor for mTORC1 subunit 1", "gene_name": "CASTOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q969R8-1", "protein_name": "KICSTOR complex protein ITFG2", "gene_name": "ITFG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VZM2-1", "protein_name": "Ras-related GTP-binding protein B", "gene_name": "RRAGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NEY4-1", "protein_name": "V-type proton ATPase subunit C 2", "gene_name": "ATP6V1C2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5T011-1", "protein_name": "KICSTOR complex protein SZT2", "gene_name": "SZT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5K8-1", "protein_name": "V-type proton ATPase subunit D", "gene_name": "ATP6V1D", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N8Y2-1", "protein_name": "V-type proton ATPase subunit d 2", "gene_name": "ATP6V0D2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15313-1", "protein_name": "V-type proton ATPase subunit B, kidney isoform", "gene_name": "ATP6V1B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6IAA8-1", "protein_name": "Ragulator complex protein LAMTOR1", "gene_name": "LAMTOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BVC4-1", "protein_name": "Target of rapamycin complex subunit LST8", "gene_name": "MLST8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q0VGL1-1", "protein_name": "Ragulator complex protein LAMTOR4", "gene_name": "LAMTOR4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43504-1", "protein_name": "Ragulator complex protein LAMTOR5", "gene_name": "LAMTOR5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7L523-1", "protein_name": "Ras-related GTP-binding protein A", "gene_name": "RRAGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N122-1", "protein_name": "Regulatory-associated protein of mTOR", "gene_name": "RPTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42345-1", "protein_name": "Serine/threonine-protein kinase mTOR", "gene_name": "MTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96A05-1", "protein_name": "V-type proton ATPase subunit E 2", "gene_name": "ATP6V1E2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TF40-1", "protein_name": "Folliculin-interacting protein 1", "gene_name": "FNIP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFG4-1", "protein_name": "Folliculin", "gene_name": "FLCN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9P278-1", "protein_name": "Folliculin-interacting protein 2", "gene_name": "FNIP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NHE4-1", "protein_name": "V-type proton ATPase subunit e 2", "gene_name": "ATP6V0E2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q1RMZ1-1", "protein_name": "S-adenosylmethionine sensor upstream of mTORC1", "gene_name": "SAMTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75140-10", "protein_name": "GATOR1 complex protein DEPDC5", "gene_name": "DEPDC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15382-1", "protein_name": "GTP-binding protein Rheb", "gene_name": "RHEB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21281-1", "protein_name": "V-type proton ATPase subunit B, brain isoform", "gene_name": "ATP6V1B2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UI12-1", "protein_name": "V-type proton ATPase subunit H", "gene_name": "ATP6V1H", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13488-1", "protein_name": "V-type proton ATPase 116 kDa subunit a 3", "gene_name": "TCIRG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15342-1", "protein_name": "V-type proton ATPase subunit e 1", "gene_name": "ATP6V0E1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16864-1", "protein_name": "V-type proton ATPase subunit F", "gene_name": "ATP6V1F", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96LB4-1", "protein_name": "V-type proton ATPase subunit G 3", "gene_name": "ATP6V1G3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27449-1", "protein_name": "V-type proton ATPase 16 kDa proteolipid subunit c", "gene_name": "ATP6V0C", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NXC5-1", "protein_name": "GATOR2 complex protein MIOS", "gene_name": "MIOS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61421-1", "protein_name": "V-type proton ATPase subunit d 1", "gene_name": "ATP6V0D1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95670-1", "protein_name": "V-type proton ATPase subunit G 2", "gene_name": "ATP6V1G2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36543-1", "protein_name": "V-type proton ATPase subunit E 1", "gene_name": "ATP6V1E1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38606-1", "protein_name": "V-type proton ATPase catalytic subunit A", "gene_name": "ATP6V1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99437-1", "protein_name": "V-type proton ATPase 21 kDa proteolipid subunit c''", "gene_name": "ATP6V0B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PJI9-1", "protein_name": "GATOR2 complex protein WDR59", "gene_name": "WDR59", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.25457612", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 55 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], 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}, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.", "journal": "Nature", "date": "2015", "authors": "Rebsamen M, Pochini L, Stasyk T, de Araujo ME, Galluccio M, Kandasamy RK, Snijder B, 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Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.", "journal": "Science (New York, N.Y.)", "date": "2015", "authors": "Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, Park J, Sabatini BL, Sabatini DM", "reference": { "type": "PubMed", "id": "25567906", "url": "https://pubmed.ncbi.nlm.nih.gov/25567906" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NBW4-1", "protein_name": "Neutral amino acid transporter 9", "gene_name": "SLC38A9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P58004-1", "protein_name": "Sestrin-2", "gene_name": "SESN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HCK5-1", "protein_name": "Protein argonaute-4", "gene_name": "AGO4", "tax_name": "Human" }, 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"TP63", "tax_name": "Human" }, { "uniprot_canonical_ac": "P10599-1", "protein_name": "Thioredoxin", "gene_name": "TXN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14406-1", "protein_name": "Cytochrome c oxidase subunit 7A2, mitochondrial", "gene_name": "COX7A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24310-1", "protein_name": "Cytochrome c oxidase subunit 7A1, mitochondrial", "gene_name": "COX7A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VZM2-1", "protein_name": "Ras-related GTP-binding protein B", "gene_name": "RRAGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P32119-1", "protein_name": "Peroxiredoxin-2", "gene_name": "PRDX2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24311-1", "protein_name": "Cytochrome c oxidase subunit 7B, mitochondrial", "gene_name": "COX7B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6YFQ2-1", "protein_name": "Cytochrome c oxidase subunit 6B2", "gene_name": "COX6B2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18283-1", "protein_name": "Glutathione peroxidase 2", "gene_name": "GPX2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94925-1", "protein_name": "Glutaminase kidney isoform, mitochondrial", "gene_name": "GLS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UI32-1", "protein_name": "Glutaminase liver isoform, mitochondrial", "gene_name": "GLS2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6IAA8-1", "protein_name": "Ragulator complex protein LAMTOR1", "gene_name": "LAMTOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BVC4-1", "protein_name": "Target of rapamycin complex subunit LST8", "gene_name": "MLST8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q0VGL1-1", "protein_name": "Ragulator complex protein LAMTOR4", "gene_name": "LAMTOR4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43504-1", "protein_name": "Ragulator complex protein LAMTOR5", "gene_name": "LAMTOR5", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"tax_name": "Human" }, { "uniprot_canonical_ac": "P27348-1", "protein_name": "14-3-3 protein theta", "gene_name": "YWHAQ", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54646-1", "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-2", "gene_name": "PRKAA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61981-1", "protein_name": "14-3-3 protein gamma", "gene_name": "YWHAG", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UGJ0-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-2", "gene_name": "PRKAG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y478-1", "protein_name": "5'-AMP-activated protein kinase subunit beta-1", "gene_name": "PRKAB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04637-1", "protein_name": "Cellular tumor antigen p53", "gene_name": "TP53", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": 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"sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "SLUG is a direct transcriptional repressor of PTEN tumor suppressor.", "journal": "The Prostate", "date": "2015", "authors": "Uygur B, Abramo K, Leikina E, Vary C, Liaw L, Wu WS", "reference": { "type": "PubMed", "id": "25728608", "url": "https://pubmed.ncbi.nlm.nih.gov/25728608" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NBW4-1", "protein_name": "Neutral amino acid transporter 9", "gene_name": "SLC38A9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HC52-1", "protein_name": "Chromobox protein homolog 8", "gene_name": "CBX8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P28482-1", "protein_name": "Mitogen-activated protein kinase 1", "gene_name": "MAPK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15336-1", "protein_name": "Cyclic AMP-dependent transcription factor ATF-2", "gene_name": "ATF2", "tax_name": "Human" }, { 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"protein_name": "Histone-binding protein RBBP7", "gene_name": "RBBP7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NDX5-1", "protein_name": "Polyhomeotic-like protein 3", "gene_name": "PHC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UJQ4-1", "protein_name": "Sal-like protein 4", "gene_name": "SALL4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43623-1", "protein_name": "Zinc finger protein SNAI2", "gene_name": "SNAI2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75530-1", "protein_name": "Polycomb protein EED", "gene_name": "EED", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15910-1", "protein_name": "Histone-lysine N-methyltransferase EZH2", "gene_name": "EZH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54259-1", "protein_name": "Atrophin-1", "gene_name": "ATN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95983-1", "protein_name": "Methyl-CpG-binding domain protein 3", "gene_name": "MBD3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14839-1", "protein_name": "ATP-dependent chromatin remodeler CHD4", "gene_name": "CHD4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14781-1", "protein_name": "Chromobox protein homolog 2", "gene_name": "CBX2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VZM2-1", "protein_name": "Ras-related GTP-binding protein B", "gene_name": "RRAGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09028-1", "protein_name": "Histone-binding protein RBBP4", "gene_name": "RBBP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6IAA8-1", "protein_name": "Ragulator complex protein LAMTOR1", "gene_name": "LAMTOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BVC4-1", "protein_name": "Target of rapamycin complex subunit LST8", "gene_name": "MLST8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q0VGL1-1", "protein_name": "Ragulator complex protein LAMTOR4", "gene_name": "LAMTOR4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43504-1", "protein_name": "Ragulator complex protein LAMTOR5", "gene_name": "LAMTOR5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7L523-1", "protein_name": "Ras-related GTP-binding protein A", "gene_name": "RRAGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15379-1", "protein_name": "Histone deacetylase 3", "gene_name": "HDAC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WUI4-1", "protein_name": "Histone deacetylase 7", "gene_name": "HDAC7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQL6-1", "protein_name": "Histone deacetylase 5", "gene_name": "HDAC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IXK0-1", "protein_name": "Polyhomeotic-like protein 2", "gene_name": "PHC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N122-1", "protein_name": "Regulatory-associated protein of mTOR", "gene_name": "RPTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60341-1", "protein_name": "Lysine-specific histone demethylase 1A", "gene_name": "KDM1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42345-1", "protein_name": "Serine/threonine-protein kinase mTOR", "gene_name": "MTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95863-1", "protein_name": "Zinc finger protein SNAI1", "gene_name": "SNAI1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q03112-7", "protein_name": "Histone-lysine N-methyltransferase MECOM", "gene_name": "MECOM", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12873-1", "protein_name": "ATP-dependent chromatin remodeler CHD3", "gene_name": "CHD3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92769-1", "protein_name": "Histone deacetylase 2", "gene_name": "HDAC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95503-1", "protein_name": "Chromobox protein homolog 6", "gene_name": "CBX6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35226-1", "protein_name": "Polycomb complex protein BMI-1", "gene_name": "BMI1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P78364-1", "protein_name": "Polyhomeotic-like protein 1", "gene_name": "PHC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99496-1", "protein_name": "E3 ubiquitin-protein ligase RING2", "gene_name": "RNF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06587-1", "protein_name": "E3 ubiquitin-protein ligase RING1", "gene_name": "RING1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94776-1", "protein_name": "Metastasis-associated protein MTA2", "gene_name": "MTA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BTC8-1", "protein_name": "Metastasis-associated protein MTA3", "gene_name": "MTA3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15382-1", "protein_name": "GTP-binding protein Rheb", "gene_name": "RHEB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UKL0-1", "protein_name": "REST corepressor 1", "gene_name": "RCOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y466-1", "protein_name": "Nuclear receptor subfamily 2 group E member 1", "gene_name": "NR2E1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27361-1", "protein_name": "Mitogen-activated protein kinase 3", "gene_name": "MAPK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H063-1", "protein_name": "Repressor of RNA polymerase III transcription MAF1 homolog", "gene_name": "MAF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15022-1", "protein_name": "Polycomb protein SUZ12", "gene_name": "SUZ12", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13127-1", "protein_name": "RE1-silencing transcription factor", "gene_name": "REST", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05412-1", "protein_name": "Transcription factor Jun", "gene_name": "JUN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WXI9-1", "protein_name": "Transcriptional repressor p66-beta", "gene_name": "GATAD2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00257-1", "protein_name": "E3 SUMO-protein ligase CBX4", "gene_name": "CBX4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04637-1", "protein_name": "Cellular tumor antigen p53", "gene_name": "TP53", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.25728608", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 59 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Sestrin2 inhibits mTORC1 through modulation of GATOR complexes.", "journal": "Scientific reports", "date": "2015", "authors": "Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan KL, Karin M, Lee JH", "reference": { "type": "PubMed", "id": "25819761", "url": "https://pubmed.ncbi.nlm.nih.gov/25819761" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NBW4-1", "protein_name": "Neutral amino acid transporter 9", "gene_name": "SLC38A9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P58004-1", "protein_name": "Sestrin-2", "gene_name": "SESN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96S15-1", "protein_name": "GATOR2 complex protein WDR24", "gene_name": "WDR24", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21283-1", "protein_name": "V-type proton ATPase subunit C 1", "gene_name": "ATP6V1C1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQL2-1", "protein_name": "Ras-related GTP-binding protein D", "gene_name": "RRAGD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HB90-1", "protein_name": "Ras-related GTP-binding protein C", "gene_name": "RRAGC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9P0V3-1", "protein_name": "SH3 domain-binding protein 4", "gene_name": "SH3BP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75348-1", "protein_name": "V-type proton ATPase subunit G 1", "gene_name": "ATP6V1G1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y664-1", "protein_name": "KICSTOR complex protein kaptin", "gene_name": "KPTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MD2-1", "protein_name": "KICSTOR subunit 2", "gene_name": "KICS2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12980-1", "protein_name": "GATOR1 complex protein NPRL3", "gene_name": "NPRL3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WTW4-1", "protein_name": "GATOR1 complex protein NPRL2", "gene_name": "NPRL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96EE3-2", "protein_name": "Nucleoporin SEH1", "gene_name": "SEH1L", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55735-1", "protein_name": "Protein SEC13 homolog", "gene_name": "SEC13", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6P5-1", "protein_name": "Sestrin-1", "gene_name": "SESN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "A6NHX0-1", "protein_name": "Cytosolic arginine sensor for mTORC1 subunit 2", "gene_name": "CASTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WTX7-1", "protein_name": "Cytosolic arginine sensor for mTORC1 subunit 1", "gene_name": "CASTOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q969R8-1", "protein_name": "KICSTOR complex protein ITFG2", "gene_name": "ITFG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VZM2-1", "protein_name": "Ras-related GTP-binding protein B", "gene_name": "RRAGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NEY4-1", "protein_name": "V-type proton ATPase subunit C 2", "gene_name": "ATP6V1C2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5T011-1", "protein_name": "KICSTOR complex protein SZT2", "gene_name": "SZT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5K8-1", "protein_name": "V-type proton ATPase subunit D", "gene_name": "ATP6V1D", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N8Y2-1", "protein_name": "V-type proton ATPase subunit d 2", "gene_name": "ATP6V0D2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15313-1", "protein_name": "V-type proton ATPase subunit B, kidney isoform", "gene_name": "ATP6V1B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6IAA8-1", "protein_name": "Ragulator complex protein LAMTOR1", "gene_name": "LAMTOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BVC4-1", "protein_name": "Target of rapamycin complex subunit LST8", "gene_name": "MLST8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q0VGL1-1", "protein_name": "Ragulator complex protein LAMTOR4", "gene_name": "LAMTOR4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43504-1", "protein_name": "Ragulator complex protein LAMTOR5", "gene_name": "LAMTOR5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7L523-1", "protein_name": "Ras-related GTP-binding protein A", "gene_name": "RRAGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N122-1", "protein_name": "Regulatory-associated protein of mTOR", "gene_name": "RPTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42345-1", "protein_name": "Serine/threonine-protein kinase mTOR", "gene_name": "MTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96A05-1", "protein_name": "V-type proton ATPase subunit E 2", "gene_name": "ATP6V1E2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TF40-1", "protein_name": "Folliculin-interacting protein 1", "gene_name": "FNIP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFG4-1", "protein_name": "Folliculin", "gene_name": "FLCN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9P278-1", "protein_name": "Folliculin-interacting protein 2", "gene_name": "FNIP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NHE4-1", "protein_name": "V-type proton ATPase subunit e 2", "gene_name": "ATP6V0E2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q1RMZ1-1", "protein_name": "S-adenosylmethionine sensor upstream of mTORC1", "gene_name": "SAMTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75140-10", "protein_name": "GATOR1 complex protein DEPDC5", "gene_name": "DEPDC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15382-1", "protein_name": "GTP-binding protein Rheb", "gene_name": "RHEB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21281-1", "protein_name": "V-type proton ATPase subunit B, brain isoform", "gene_name": "ATP6V1B2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UI12-1", "protein_name": "V-type proton ATPase subunit H", "gene_name": "ATP6V1H", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13488-1", "protein_name": "V-type proton ATPase 116 kDa subunit a 3", "gene_name": "TCIRG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15342-1", "protein_name": "V-type proton ATPase subunit e 1", "gene_name": "ATP6V0E1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16864-1", "protein_name": "V-type proton ATPase subunit F", "gene_name": "ATP6V1F", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96LB4-1", "protein_name": "V-type proton ATPase subunit G 3", "gene_name": "ATP6V1G3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27449-1", "protein_name": "V-type proton ATPase 16 kDa proteolipid subunit c", "gene_name": "ATP6V0C", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NXC5-1", "protein_name": "GATOR2 complex protein MIOS", "gene_name": "MIOS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61421-1", "protein_name": "V-type proton ATPase subunit d 1", "gene_name": "ATP6V0D1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95670-1", "protein_name": "V-type proton ATPase subunit G 2", "gene_name": "ATP6V1G2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36543-1", "protein_name": "V-type proton ATPase subunit E 1", "gene_name": "ATP6V1E1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38606-1", "protein_name": "V-type proton ATPase catalytic subunit A", "gene_name": "ATP6V1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99437-1", "protein_name": 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[] } ] }, { "title": "Sestrin2 is a leucine sensor for the mTORC1 pathway.", "journal": "Science (New York, N.Y.)", "date": "2016", "authors": "Wolfson RL, Chantranupong L, Saxton RA, Shen K, Scaria SM, Cantor JR, Sabatini DM", "reference": { "type": "PubMed", "id": "26449471", "url": "https://pubmed.ncbi.nlm.nih.gov/26449471" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NBW4-1", "protein_name": "Neutral amino acid transporter 9", "gene_name": "SLC38A9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P58004-1", "protein_name": "Sestrin-2", "gene_name": "SESN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P58005-1", "protein_name": "Sestrin-3", "gene_name": "SESN3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96S15-1", "protein_name": "GATOR2 complex protein WDR24", "gene_name": "WDR24", 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"protein_name": "GATOR1 complex protein NPRL3", "gene_name": "NPRL3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WTW4-1", "protein_name": "GATOR1 complex protein NPRL2", "gene_name": "NPRL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96EE3-2", "protein_name": "Nucleoporin SEH1", "gene_name": "SEH1L", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55735-1", "protein_name": "Protein SEC13 homolog", "gene_name": "SEC13", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6P5-1", "protein_name": "Sestrin-1", "gene_name": "SESN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "A6NHX0-1", "protein_name": "Cytosolic arginine sensor for mTORC1 subunit 2", "gene_name": "CASTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WTX7-1", "protein_name": "Cytosolic arginine sensor for mTORC1 subunit 1", "gene_name": "CASTOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q969R8-1", "protein_name": "KICSTOR complex protein ITFG2", "gene_name": "ITFG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VZM2-1", "protein_name": "Ras-related GTP-binding protein B", "gene_name": "RRAGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NEY4-1", "protein_name": "V-type proton ATPase subunit C 2", "gene_name": "ATP6V1C2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5T011-1", "protein_name": "KICSTOR complex protein SZT2", "gene_name": "SZT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5K8-1", "protein_name": "V-type proton ATPase subunit D", "gene_name": "ATP6V1D", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N8Y2-1", "protein_name": "V-type proton ATPase subunit d 2", "gene_name": "ATP6V0D2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15313-1", "protein_name": "V-type proton ATPase subunit B, kidney isoform", "gene_name": "ATP6V1B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6IAA8-1", "protein_name": "Ragulator complex protein LAMTOR1", "gene_name": "LAMTOR1", "tax_name": "Human" }, { 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}, { "uniprot_canonical_ac": "Q9NX09-1", "protein_name": "DNA damage-inducible transcript 4 protein", "gene_name": "DDIT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49815-1", "protein_name": "Tuberin", "gene_name": "TSC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62258-1", "protein_name": "14-3-3 protein epsilon", "gene_name": "YWHAE", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63104-1", "protein_name": "14-3-3 protein zeta/delta", "gene_name": "YWHAZ", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54619-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-1", "gene_name": "PRKAG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04917-1", "protein_name": "14-3-3 protein eta", "gene_name": "YWHAH", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43741-1", "protein_name": "5'-AMP-activated protein kinase subunit beta-2", "gene_name": "PRKAB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31946-1", "protein_name": "14-3-3 protein 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"count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "MAF1 suppresses AKT-mTOR signaling and liver cancer through activation of PTEN transcription.", "journal": "Hepatology (Baltimore, Md.)", "date": "2016", "authors": "Li Y, Tsang CK, Wang S, Li XX, Yang Y, Fu L, Huang W, Li M, Wang HY, Zheng XF", "reference": { "type": "PubMed", "id": "26910647", "url": "https://pubmed.ncbi.nlm.nih.gov/26910647" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NBW4-1", "protein_name": "Neutral amino acid transporter 9", "gene_name": "SLC38A9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HC52-1", "protein_name": "Chromobox protein homolog 8", "gene_name": "CBX8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P28482-1", "protein_name": "Mitogen-activated protein kinase 1", "gene_name": "MAPK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15336-1", "protein_name": "Cyclic AMP-dependent transcription factor ATF-2", "gene_name": "ATF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18146-1", "protein_name": "Early growth response protein 1", "gene_name": "EGR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13330-1", "protein_name": "Metastasis-associated protein MTA1", "gene_name": "MTA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13547-1", "protein_name": "Histone deacetylase 1", "gene_name": "HDAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86YP4-1", "protein_name": "Transcriptional repressor p66-alpha", "gene_name": "GATAD2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQL2-1", "protein_name": "Ras-related GTP-binding protein D", "gene_name": "RRAGD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HB90-1", "protein_name": "Ras-related GTP-binding protein C", "gene_name": "RRAGC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P37231-1", "protein_name": "Peroxisome proliferator-activated receptor gamma", "gene_name": "PPARG", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16576-1", "protein_name": "Histone-binding protein RBBP7", "gene_name": "RBBP7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NDX5-1", "protein_name": "Polyhomeotic-like protein 3", "gene_name": "PHC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UJQ4-1", "protein_name": "Sal-like protein 4", "gene_name": "SALL4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43623-1", "protein_name": "Zinc finger protein SNAI2", "gene_name": "SNAI2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75530-1", "protein_name": "Polycomb protein EED", "gene_name": "EED", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15910-1", "protein_name": "Histone-lysine N-methyltransferase EZH2", "gene_name": "EZH2", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"gene_name": "MLST8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q0VGL1-1", "protein_name": "Ragulator complex protein LAMTOR4", "gene_name": "LAMTOR4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43504-1", "protein_name": "Ragulator complex protein LAMTOR5", "gene_name": "LAMTOR5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7L523-1", "protein_name": "Ras-related GTP-binding protein A", "gene_name": "RRAGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15379-1", "protein_name": "Histone deacetylase 3", "gene_name": "HDAC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WUI4-1", "protein_name": "Histone deacetylase 7", "gene_name": "HDAC7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQL6-1", "protein_name": "Histone deacetylase 5", "gene_name": "HDAC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IXK0-1", "protein_name": "Polyhomeotic-like protein 2", "gene_name": "PHC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N122-1", "protein_name": "Regulatory-associated protein of mTOR", "gene_name": "RPTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60341-1", "protein_name": "Lysine-specific histone demethylase 1A", "gene_name": "KDM1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42345-1", "protein_name": "Serine/threonine-protein kinase mTOR", "gene_name": "MTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95863-1", "protein_name": "Zinc finger protein SNAI1", "gene_name": "SNAI1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q03112-7", "protein_name": "Histone-lysine N-methyltransferase MECOM", "gene_name": "MECOM", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12873-1", "protein_name": "ATP-dependent chromatin remodeler CHD3", "gene_name": "CHD3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92769-1", "protein_name": "Histone deacetylase 2", "gene_name": "HDAC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95503-1", "protein_name": "Chromobox protein homolog 6", "gene_name": "CBX6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35226-1", "protein_name": "Polycomb complex protein BMI-1", "gene_name": "BMI1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P78364-1", "protein_name": "Polyhomeotic-like protein 1", "gene_name": "PHC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99496-1", "protein_name": "E3 ubiquitin-protein ligase RING2", "gene_name": "RNF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06587-1", "protein_name": "E3 ubiquitin-protein ligase RING1", "gene_name": "RING1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O94776-1", "protein_name": "Metastasis-associated protein MTA2", "gene_name": "MTA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BTC8-1", "protein_name": "Metastasis-associated protein MTA3", "gene_name": "MTA3", "tax_name": "Human" }, { 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"protein_name": "Transcription factor Jun", "gene_name": "JUN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WXI9-1", "protein_name": "Transcriptional repressor p66-beta", "gene_name": "GATAD2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00257-1", "protein_name": "E3 SUMO-protein ligase CBX4", "gene_name": "CBX4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04637-1", "protein_name": "Cellular tumor antigen p53", "gene_name": "TP53", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.26910647", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 59 } ], 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"tax_name": "Human" }, { "uniprot_canonical_ac": "P61421-1", "protein_name": "V-type proton ATPase subunit d 1", "gene_name": "ATP6V0D1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95670-1", "protein_name": "V-type proton ATPase subunit G 2", "gene_name": "ATP6V1G2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36543-1", "protein_name": "V-type proton ATPase subunit E 1", "gene_name": "ATP6V1E1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38606-1", "protein_name": "V-type proton ATPase catalytic subunit A", "gene_name": "ATP6V1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99437-1", "protein_name": "V-type proton ATPase 21 kDa proteolipid subunit c''", "gene_name": "ATP6V0B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PJI9-1", "protein_name": "GATOR2 complex protein WDR59", "gene_name": "WDR59", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": 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"sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Mechanism of arginine sensing by CASTOR1 upstream of mTORC1.", "journal": "Nature", "date": "2016", "authors": "Saxton RA, Chantranupong L, Knockenhauer KE, Schwartz TU, Sabatini DM", "reference": { "type": "PubMed", "id": "27487210", "url": "https://pubmed.ncbi.nlm.nih.gov/27487210" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NBW4-1", "protein_name": "Neutral amino acid transporter 9", "gene_name": "SLC38A9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P58004-1", "protein_name": "Sestrin-2", "gene_name": "SESN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96S15-1", "protein_name": "GATOR2 complex protein WDR24", "gene_name": "WDR24", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21283-1", "protein_name": "V-type proton ATPase subunit C 1", "gene_name": "ATP6V1C1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQL2-1", "protein_name": "Ras-related GTP-binding protein D", "gene_name": "RRAGD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HB90-1", "protein_name": "Ras-related GTP-binding protein C", "gene_name": "RRAGC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9P0V3-1", "protein_name": "SH3 domain-binding protein 4", "gene_name": "SH3BP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75348-1", "protein_name": "V-type proton ATPase subunit G 1", "gene_name": "ATP6V1G1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y664-1", "protein_name": "KICSTOR complex protein kaptin", "gene_name": "KPTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MD2-1", "protein_name": "KICSTOR subunit 2", "gene_name": "KICS2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12980-1", "protein_name": "GATOR1 complex protein NPRL3", "gene_name": "NPRL3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WTW4-1", "protein_name": "GATOR1 complex protein NPRL2", "gene_name": "NPRL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96EE3-2", "protein_name": "Nucleoporin SEH1", "gene_name": "SEH1L", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55735-1", "protein_name": "Protein SEC13 homolog", "gene_name": "SEC13", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6P5-1", "protein_name": "Sestrin-1", "gene_name": "SESN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "A6NHX0-1", "protein_name": "Cytosolic arginine sensor for mTORC1 subunit 2", "gene_name": "CASTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WTX7-1", "protein_name": "Cytosolic arginine sensor for mTORC1 subunit 1", "gene_name": "CASTOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q969R8-1", "protein_name": "KICSTOR complex protein ITFG2", "gene_name": "ITFG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VZM2-1", "protein_name": "Ras-related GTP-binding protein B", "gene_name": "RRAGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NEY4-1", "protein_name": "V-type proton ATPase subunit C 2", "gene_name": "ATP6V1C2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5T011-1", "protein_name": "KICSTOR complex protein SZT2", "gene_name": "SZT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5K8-1", "protein_name": "V-type proton ATPase subunit D", "gene_name": "ATP6V1D", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N8Y2-1", "protein_name": "V-type proton ATPase subunit d 2", "gene_name": "ATP6V0D2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15313-1", "protein_name": "V-type proton ATPase subunit B, kidney isoform", "gene_name": "ATP6V1B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6IAA8-1", "protein_name": "Ragulator complex protein LAMTOR1", "gene_name": "LAMTOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BVC4-1", "protein_name": "Target of rapamycin complex subunit LST8", "gene_name": "MLST8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q0VGL1-1", "protein_name": "Ragulator complex protein LAMTOR4", "gene_name": "LAMTOR4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43504-1", "protein_name": "Ragulator complex protein LAMTOR5", "gene_name": "LAMTOR5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7L523-1", "protein_name": "Ras-related GTP-binding protein A", "gene_name": "RRAGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N122-1", "protein_name": "Regulatory-associated protein of mTOR", "gene_name": "RPTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42345-1", "protein_name": "Serine/threonine-protein kinase mTOR", "gene_name": "MTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96A05-1", "protein_name": "V-type proton ATPase subunit E 2", "gene_name": "ATP6V1E2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TF40-1", "protein_name": "Folliculin-interacting protein 1", "gene_name": "FNIP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFG4-1", "protein_name": "Folliculin", "gene_name": "FLCN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9P278-1", "protein_name": "Folliculin-interacting protein 2", "gene_name": "FNIP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NHE4-1", "protein_name": "V-type proton ATPase subunit e 2", "gene_name": "ATP6V0E2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q1RMZ1-1", "protein_name": "S-adenosylmethionine sensor upstream of mTORC1", "gene_name": "SAMTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75140-10", "protein_name": "GATOR1 complex protein DEPDC5", "gene_name": "DEPDC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15382-1", "protein_name": "GTP-binding protein Rheb", "gene_name": "RHEB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21281-1", "protein_name": "V-type proton ATPase subunit B, brain isoform", "gene_name": "ATP6V1B2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UI12-1", "protein_name": "V-type proton ATPase subunit H", "gene_name": "ATP6V1H", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13488-1", "protein_name": "V-type proton ATPase 116 kDa subunit a 3", "gene_name": "TCIRG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15342-1", "protein_name": "V-type proton ATPase subunit e 1", "gene_name": "ATP6V0E1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16864-1", "protein_name": "V-type proton ATPase subunit F", "gene_name": "ATP6V1F", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96LB4-1", "protein_name": "V-type proton ATPase subunit G 3", "gene_name": "ATP6V1G3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27449-1", "protein_name": "V-type proton ATPase 16 kDa proteolipid subunit c", "gene_name": "ATP6V0C", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NXC5-1", "protein_name": "GATOR2 complex protein MIOS", "gene_name": "MIOS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61421-1", "protein_name": "V-type proton ATPase subunit d 1", "gene_name": "ATP6V0D1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95670-1", "protein_name": "V-type proton ATPase subunit G 2", "gene_name": "ATP6V1G2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36543-1", "protein_name": "V-type proton ATPase subunit E 1", "gene_name": "ATP6V1E1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38606-1", "protein_name": "V-type proton ATPase catalytic subunit A", "gene_name": "ATP6V1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99437-1", "protein_name": "V-type proton ATPase 21 kDa proteolipid subunit c''", "gene_name": "ATP6V0B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PJI9-1", "protein_name": "GATOR2 complex protein WDR59", "gene_name": "WDR59", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 108, "end_pos": 110, "sequence_org": "HHV", "sequence_mut": "QNI", "comment": "Loss of arginine-binding. 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Loss of interaction with the GATOR2 complex which constitutively activates the TORC1 signaling pathway.", "evidence": [ { "database": "UniProtKB", "id": "Q8WTX7", "url": "https://www.uniprot.org/uniprotkb/Q8WTX7" }, { "database": "PubMed", "id": "27487210", "url": "https://pubmed.ncbi.nlm.nih.gov/27487210" } ], "uniprot_canonical_ac": "Q8WTX7-1" }, { "start_pos": 121, "end_pos": 121, "sequence_org": "D", "sequence_mut": "A", "comment": "No effect on arginine-binding. No effect on homodimerization. Loss of interaction with the GATOR2 complex which constitutively activates the TORC1 signaling pathway.", "evidence": [ { "database": "UniProtKB", "id": "Q8WTX7", "url": "https://www.uniprot.org/uniprotkb/Q8WTX7" }, { "database": "PubMed", "id": "27487210", "url": "https://pubmed.ncbi.nlm.nih.gov/27487210" } ], "uniprot_canonical_ac": "Q8WTX7-1" }, { "start_pos": 126, "end_pos": 126, "sequence_org": "R", "sequence_mut": "A", "comment": "Decreased arginine-binding. 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Decreased interaction with the GATOR2 complex which constitutively activates the TORC1 signaling pathway.", "evidence": [ { "database": "UniProtKB", "id": "Q8WTX7", "url": "https://www.uniprot.org/uniprotkb/Q8WTX7" }, { "database": "PubMed", "id": "27487210", "url": "https://pubmed.ncbi.nlm.nih.gov/27487210" } ], "uniprot_canonical_ac": "Q8WTX7-1" }, { "start_pos": 207, "end_pos": 207, "sequence_org": "Y", "sequence_mut": "S", "comment": "No effect on arginine-binding. Loss of homodimerization. Decreased interaction with the GATOR2 complex which constitutively activates the TORC1 signaling pathway.", "evidence": [ { "database": "UniProtKB", "id": "Q8WTX7", "url": "https://www.uniprot.org/uniprotkb/Q8WTX7" }, { "database": "PubMed", "id": "27487210", "url": "https://pubmed.ncbi.nlm.nih.gov/27487210" } ], "uniprot_canonical_ac": "Q8WTX7-1" }, { "start_pos": 261, "end_pos": 261, "sequence_org": "E", "sequence_mut": "A", "comment": "No effect on arginine-binding. No effect on homodimerization. Loss of interaction with the GATOR2 complex.", "evidence": [ { "database": "UniProtKB", "id": "Q8WTX7", "url": "https://www.uniprot.org/uniprotkb/Q8WTX7" }, { "database": "PubMed", "id": "27487210", "url": "https://pubmed.ncbi.nlm.nih.gov/27487210" } ], "uniprot_canonical_ac": "Q8WTX7-1" }, { "start_pos": 264, "end_pos": 264, "sequence_org": "R", "sequence_mut": "A", "comment": "No effect on interaction with the GATOR2 complex.", "evidence": [ { "database": "UniProtKB", "id": "Q8WTX7", "url": "https://www.uniprot.org/uniprotkb/Q8WTX7" }, { "database": "PubMed", "id": "27487210", "url": "https://pubmed.ncbi.nlm.nih.gov/27487210" } ], "uniprot_canonical_ac": "Q8WTX7-1" }, { "start_pos": 276, "end_pos": 276, "sequence_org": "D", "sequence_mut": "A", "comment": "Decreased arginine-binding. Constitutively interacts with the GATOR2 complex.", "evidence": [ { "database": "UniProtKB", "id": "Q8WTX7", "url": "https://www.uniprot.org/uniprotkb/Q8WTX7" }, { "database": "PubMed", "id": "27487210", "url": "https://pubmed.ncbi.nlm.nih.gov/27487210" } ], "uniprot_canonical_ac": "Q8WTX7-1" }, { "start_pos": 277, "end_pos": 277, "sequence_org": "E", "sequence_mut": "A", "comment": "Decreased arginine-binding. Constitutively interacts with the GATOR2 complex.", "evidence": [ { "database": "UniProtKB", "id": "Q8WTX7", "url": "https://www.uniprot.org/uniprotkb/Q8WTX7" }, { "database": "PubMed", "id": "27487210", "url": "https://pubmed.ncbi.nlm.nih.gov/27487210" } ], "uniprot_canonical_ac": "Q8WTX7-1" }, { "start_pos": 278, "end_pos": 278, "sequence_org": "C", "sequence_mut": "A", "comment": "Decreased arginine-binding. Constitutively interacts with the GATOR2 complex.", "evidence": [ { "database": "UniProtKB", "id": "Q8WTX7", "url": "https://www.uniprot.org/uniprotkb/Q8WTX7" }, { "database": "PubMed", "id": "27487210", "url": "https://pubmed.ncbi.nlm.nih.gov/27487210" } ], "uniprot_canonical_ac": "Q8WTX7-1" }, { "start_pos": 292, "end_pos": 292, "sequence_org": "D", "sequence_mut": "A", "comment": "No effect on arginine-binding. No effect on homodimerization. Loss of interaction with the GATOR2 complex.", "evidence": [ { "database": "UniProtKB", "id": "Q8WTX7", "url": "https://www.uniprot.org/uniprotkb/Q8WTX7" }, { "database": "PubMed", "id": "27487210", "url": "https://pubmed.ncbi.nlm.nih.gov/27487210" } ], "uniprot_canonical_ac": "Q8WTX7-1" }, { "start_pos": 302, "end_pos": 302, "sequence_org": "N", "sequence_mut": "K", "comment": "No effect on interaction with the GATOR2 complex.", "evidence": [ { "database": "UniProtKB", "id": "Q8WTX7", "url": "https://www.uniprot.org/uniprotkb/Q8WTX7" }, { "database": "PubMed", "id": "27487210", "url": "https://pubmed.ncbi.nlm.nih.gov/27487210" } ], "uniprot_canonical_ac": "Q8WTX7-1" }, { "start_pos": 304, "end_pos": 304, "sequence_org": "D", "sequence_mut": "A", "comment": "Loss of arginine-binding. Constitutively interacts with the GATOR2 complex. Constitutively inhibits the TORC1 signaling pathway.", "evidence": [ { "database": "UniProtKB", "id": "Q8WTX7", "url": "https://www.uniprot.org/uniprotkb/Q8WTX7" }, { "database": "PubMed", "id": "27487210", "url": "https://pubmed.ncbi.nlm.nih.gov/27487210" } ], "uniprot_canonical_ac": "Q8WTX7-1" }, { "start_pos": 90, "end_pos": 90, "sequence_org": "Q", "sequence_mut": "A", "comment": "No effect on interaction with the GATOR2 complex.", "evidence": [ { "database": "UniProtKB", "id": "Q8WTX7", "url": "https://www.uniprot.org/uniprotkb/Q8WTX7" }, { "database": "PubMed", "id": "27487210", "url": "https://pubmed.ncbi.nlm.nih.gov/27487210" } ], "uniprot_canonical_ac": "Q8WTX7-1" }, { "start_pos": 96, "end_pos": 96, "sequence_org": "K", "sequence_mut": "A", "comment": "No effect on interaction with the GATOR2 complex.", "evidence": [ { "database": "UniProtKB", "id": "Q8WTX7", "url": "https://www.uniprot.org/uniprotkb/Q8WTX7" }, { "database": "PubMed", "id": "27487210", "url": 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{ "uniprot_canonical_ac": "Q969R8-1", "protein_name": "KICSTOR complex protein ITFG2", "gene_name": "ITFG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VZM2-1", "protein_name": "Ras-related GTP-binding protein B", "gene_name": "RRAGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NEY4-1", "protein_name": "V-type proton ATPase subunit C 2", "gene_name": "ATP6V1C2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5T011-1", "protein_name": "KICSTOR complex protein SZT2", "gene_name": "SZT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5K8-1", "protein_name": "V-type proton ATPase subunit D", "gene_name": "ATP6V1D", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N8Y2-1", "protein_name": "V-type proton ATPase subunit d 2", "gene_name": "ATP6V0D2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15313-1", "protein_name": "V-type proton ATPase subunit B, kidney isoform", "gene_name": "ATP6V1B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6IAA8-1", "protein_name": "Ragulator complex protein LAMTOR1", "gene_name": "LAMTOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BVC4-1", "protein_name": "Target of rapamycin complex subunit LST8", "gene_name": "MLST8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q0VGL1-1", "protein_name": "Ragulator complex protein LAMTOR4", "gene_name": "LAMTOR4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43504-1", "protein_name": "Ragulator complex protein LAMTOR5", "gene_name": "LAMTOR5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7L523-1", "protein_name": "Ras-related GTP-binding protein A", "gene_name": "RRAGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N122-1", "protein_name": "Regulatory-associated protein of mTOR", "gene_name": "RPTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42345-1", "protein_name": "Serine/threonine-protein kinase mTOR", "gene_name": "MTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96A05-1", "protein_name": "V-type proton ATPase subunit E 2", "gene_name": "ATP6V1E2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TF40-1", "protein_name": "Folliculin-interacting protein 1", "gene_name": "FNIP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFG4-1", "protein_name": "Folliculin", "gene_name": "FLCN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9P278-1", "protein_name": "Folliculin-interacting protein 2", "gene_name": "FNIP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NHE4-1", "protein_name": "V-type proton ATPase subunit e 2", "gene_name": "ATP6V0E2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q1RMZ1-1", "protein_name": "S-adenosylmethionine sensor upstream of mTORC1", "gene_name": "SAMTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75140-10", "protein_name": "GATOR1 complex protein DEPDC5", "gene_name": "DEPDC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15382-1", "protein_name": "GTP-binding protein Rheb", "gene_name": "RHEB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21281-1", "protein_name": "V-type proton ATPase subunit B, brain isoform", "gene_name": "ATP6V1B2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UI12-1", "protein_name": "V-type proton ATPase subunit H", "gene_name": "ATP6V1H", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13488-1", "protein_name": "V-type proton ATPase 116 kDa subunit a 3", "gene_name": "TCIRG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15342-1", "protein_name": "V-type proton ATPase subunit e 1", "gene_name": "ATP6V0E1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16864-1", "protein_name": "V-type proton ATPase subunit F", "gene_name": "ATP6V1F", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96LB4-1", "protein_name": "V-type proton ATPase subunit G 3", "gene_name": "ATP6V1G3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27449-1", "protein_name": "V-type proton ATPase 16 kDa proteolipid subunit c", "gene_name": "ATP6V0C", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NXC5-1", "protein_name": "GATOR2 complex protein MIOS", "gene_name": "MIOS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61421-1", "protein_name": "V-type proton ATPase subunit d 1", "gene_name": "ATP6V0D1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95670-1", "protein_name": "V-type proton ATPase subunit G 2", "gene_name": "ATP6V1G2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36543-1", "protein_name": "V-type proton ATPase subunit E 1", "gene_name": "ATP6V1E1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38606-1", "protein_name": "V-type proton ATPase catalytic subunit A", "gene_name": "ATP6V1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99437-1", "protein_name": "V-type proton ATPase 21 kDa proteolipid subunit c''", "gene_name": "ATP6V0B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PJI9-1", "protein_name": "GATOR2 complex protein WDR59", "gene_name": "WDR59", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.27648300", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 55 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 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{ "uniprot_canonical_ac": "Q12980-1", "protein_name": "GATOR1 complex protein NPRL3", "gene_name": "NPRL3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WTW4-1", "protein_name": "GATOR1 complex protein NPRL2", "gene_name": "NPRL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96EE3-2", "protein_name": "Nucleoporin SEH1", "gene_name": "SEH1L", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55735-1", "protein_name": "Protein SEC13 homolog", "gene_name": "SEC13", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6P5-1", "protein_name": "Sestrin-1", "gene_name": "SESN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "A6NHX0-1", "protein_name": "Cytosolic arginine sensor for mTORC1 subunit 2", "gene_name": "CASTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WTX7-1", "protein_name": "Cytosolic arginine sensor for mTORC1 subunit 1", "gene_name": "CASTOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q969R8-1", "protein_name": "KICSTOR complex protein 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"tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BVC4-1", "protein_name": "Target of rapamycin complex subunit LST8", "gene_name": "MLST8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q0VGL1-1", "protein_name": "Ragulator complex protein LAMTOR4", "gene_name": "LAMTOR4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43504-1", "protein_name": "Ragulator complex protein LAMTOR5", "gene_name": "LAMTOR5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7L523-1", "protein_name": "Ras-related GTP-binding protein A", "gene_name": "RRAGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N122-1", "protein_name": "Regulatory-associated protein of mTOR", "gene_name": "RPTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42345-1", "protein_name": "Serine/threonine-protein kinase mTOR", "gene_name": "MTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96A05-1", "protein_name": "V-type proton ATPase subunit E 2", "gene_name": "ATP6V1E2", "tax_name": "Human" }, { 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"GTP-binding protein Rheb", "gene_name": "RHEB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21281-1", "protein_name": "V-type proton ATPase subunit B, brain isoform", "gene_name": "ATP6V1B2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UI12-1", "protein_name": "V-type proton ATPase subunit H", "gene_name": "ATP6V1H", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13488-1", "protein_name": "V-type proton ATPase 116 kDa subunit a 3", "gene_name": "TCIRG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15342-1", "protein_name": "V-type proton ATPase subunit e 1", "gene_name": "ATP6V0E1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16864-1", "protein_name": "V-type proton ATPase subunit F", "gene_name": "ATP6V1F", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96LB4-1", "protein_name": "V-type proton ATPase subunit G 3", "gene_name": "ATP6V1G3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27449-1", "protein_name": "V-type proton ATPase 16 kDa 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"gene_name": "WDR59", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.28066558", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 55 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", 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"n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.", "journal": "Nature", "date": "2017", "authors": "Wolfson RL, Chantranupong L, Wyant GA, Gu X, Orozco JM, Shen K, Condon KJ, Petri S, Kedir J, Scaria SM, Abu-Remaileh M, Frankel WN, Sabatini DM", "reference": { "type": "PubMed", "id": "28199306", "url": "https://pubmed.ncbi.nlm.nih.gov/28199306" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NBW4-1", "protein_name": "Neutral amino acid transporter 9", "gene_name": "SLC38A9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P58004-1", "protein_name": "Sestrin-2", "gene_name": "SESN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96S15-1", "protein_name": "GATOR2 complex protein WDR24", "gene_name": "WDR24", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21283-1", "protein_name": "V-type proton ATPase subunit C 1", "gene_name": "ATP6V1C1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQL2-1", "protein_name": "Ras-related GTP-binding protein D", "gene_name": "RRAGD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HB90-1", "protein_name": "Ras-related GTP-binding protein C", "gene_name": "RRAGC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9P0V3-1", "protein_name": "SH3 domain-binding protein 4", "gene_name": "SH3BP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75348-1", "protein_name": "V-type proton ATPase subunit G 1", "gene_name": "ATP6V1G1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y664-1", "protein_name": "KICSTOR complex protein kaptin", "gene_name": "KPTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MD2-1", "protein_name": "KICSTOR subunit 2", "gene_name": "KICS2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12980-1", "protein_name": "GATOR1 complex protein NPRL3", "gene_name": "NPRL3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WTW4-1", "protein_name": "GATOR1 complex protein NPRL2", "gene_name": "NPRL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96EE3-2", "protein_name": "Nucleoporin SEH1", "gene_name": "SEH1L", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55735-1", "protein_name": "Protein SEC13 homolog", "gene_name": "SEC13", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6P5-1", "protein_name": "Sestrin-1", "gene_name": "SESN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "A6NHX0-1", "protein_name": "Cytosolic arginine sensor for mTORC1 subunit 2", "gene_name": "CASTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WTX7-1", "protein_name": "Cytosolic arginine sensor for mTORC1 subunit 1", "gene_name": "CASTOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q969R8-1", "protein_name": "KICSTOR complex protein 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"tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BVC4-1", "protein_name": "Target of rapamycin complex subunit LST8", "gene_name": "MLST8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q0VGL1-1", "protein_name": "Ragulator complex protein LAMTOR4", "gene_name": "LAMTOR4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43504-1", "protein_name": "Ragulator complex protein LAMTOR5", "gene_name": "LAMTOR5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7L523-1", "protein_name": "Ras-related GTP-binding protein A", "gene_name": "RRAGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N122-1", "protein_name": "Regulatory-associated protein of mTOR", "gene_name": "RPTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42345-1", "protein_name": "Serine/threonine-protein kinase mTOR", "gene_name": "MTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96A05-1", "protein_name": "V-type proton ATPase subunit E 2", "gene_name": "ATP6V1E2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TF40-1", "protein_name": "Folliculin-interacting protein 1", "gene_name": "FNIP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFG4-1", "protein_name": "Folliculin", "gene_name": "FLCN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9P278-1", "protein_name": "Folliculin-interacting protein 2", "gene_name": "FNIP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NHE4-1", "protein_name": "V-type proton ATPase subunit e 2", "gene_name": "ATP6V0E2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q1RMZ1-1", "protein_name": "S-adenosylmethionine sensor upstream of mTORC1", "gene_name": "SAMTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75140-10", "protein_name": "GATOR1 complex protein DEPDC5", "gene_name": "DEPDC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15382-1", "protein_name": "GTP-binding protein Rheb", "gene_name": "RHEB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21281-1", "protein_name": "V-type proton ATPase subunit B, brain isoform", "gene_name": "ATP6V1B2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UI12-1", "protein_name": "V-type proton ATPase subunit H", "gene_name": "ATP6V1H", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13488-1", "protein_name": "V-type proton ATPase 116 kDa subunit a 3", "gene_name": "TCIRG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15342-1", "protein_name": "V-type proton ATPase subunit e 1", "gene_name": "ATP6V0E1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16864-1", "protein_name": "V-type proton ATPase subunit F", "gene_name": "ATP6V1F", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96LB4-1", "protein_name": "V-type proton ATPase subunit G 3", "gene_name": "ATP6V1G3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27449-1", "protein_name": "V-type proton ATPase 16 kDa 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"Q8TF40-1", "protein_name": "Folliculin-interacting protein 1", "gene_name": "FNIP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFG4-1", "protein_name": "Folliculin", "gene_name": "FLCN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9P278-1", "protein_name": "Folliculin-interacting protein 2", "gene_name": "FNIP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NHE4-1", "protein_name": "V-type proton ATPase subunit e 2", "gene_name": "ATP6V0E2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q1RMZ1-1", "protein_name": "S-adenosylmethionine sensor upstream of mTORC1", "gene_name": "SAMTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75140-10", "protein_name": "GATOR1 complex protein DEPDC5", "gene_name": "DEPDC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15382-1", "protein_name": "GTP-binding protein Rheb", "gene_name": "RHEB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21281-1", "protein_name": "V-type proton ATPase subunit B, brain isoform", "gene_name": "ATP6V1B2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UI12-1", "protein_name": "V-type proton ATPase subunit H", "gene_name": "ATP6V1H", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13488-1", "protein_name": "V-type proton ATPase 116 kDa subunit a 3", "gene_name": "TCIRG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15342-1", "protein_name": "V-type proton ATPase subunit e 1", "gene_name": "ATP6V0E1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16864-1", "protein_name": "V-type proton ATPase subunit F", "gene_name": "ATP6V1F", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96LB4-1", "protein_name": "V-type proton ATPase subunit G 3", "gene_name": "ATP6V1G3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27449-1", "protein_name": "V-type proton ATPase 16 kDa proteolipid subunit c", "gene_name": "ATP6V0C", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NXC5-1", "protein_name": "GATOR2 complex protein MIOS", "gene_name": "MIOS", "tax_name": "Human" }, { "uniprot_canonical_ac": "A2A9C3-1", "protein_name": "KICSTOR complex protein SZT2", "gene_name": "Szt2", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "P61421-1", "protein_name": "V-type proton ATPase subunit d 1", "gene_name": "ATP6V0D1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95670-1", "protein_name": "V-type proton ATPase subunit G 2", "gene_name": "ATP6V1G2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36543-1", "protein_name": "V-type proton ATPase subunit E 1", "gene_name": "ATP6V1E1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38606-1", "protein_name": "V-type proton ATPase catalytic subunit A", "gene_name": "ATP6V1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99437-1", "protein_name": "V-type proton ATPase 21 kDa proteolipid subunit c''", "gene_name": "ATP6V0B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PJI9-1", "protein_name": "GATOR2 complex protein WDR59", "gene_name": "WDR59", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.28199315", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 56 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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"species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 449, "end_pos": 449, "sequence_org": "F", "sequence_mut": "I", "comment": "Abolishes cholesterol binding; when associated with I-460. Does not affect disrupted arginine-mediated activation of mTORC1; when associated with I-460. Does not affect lysosomal localization; when associated with I-460. Increases interactions with both Rag GTPase and Ragulator subunits; when associated with I-460. Loss of L-glutamine transport stimulation by cholesterol.", "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" }, { "database": "PubMed", "id": "28336668", "url": "https://pubmed.ncbi.nlm.nih.gov/28336668" }, { "database": "PubMed", "id": "31295473", "url": "https://pubmed.ncbi.nlm.nih.gov/31295473" } ], "uniprot_canonical_ac": "Q8NBW4-1" }, { "start_pos": 460, "end_pos": 460, "sequence_org": "Y", "sequence_mut": "I", "comment": "Decreases cholesterol binding. Abolishes cholesterol binding; when associated with I-449. Does not affect disrupted arginine-mediated activation of mTORC1; when associated with I-449. Does not affect lysosomal localization; when associated with I-449. Increases interactions with both Rag GTPase and Ragulator subunits; when associated with I-449. Loss of L-glutamine transport stimulation by cholesterol.", "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" }, { "database": "PubMed", "id": "28336668", "url": "https://pubmed.ncbi.nlm.nih.gov/28336668" }, { "database": "PubMed", "id": "31295473", "url": "https://pubmed.ncbi.nlm.nih.gov/31295473" } ], "uniprot_canonical_ac": "Q8NBW4-1" } ], "record_id": "pubmed.28336668", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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"uniprot_canonical_ac": "Q99437-1", "protein_name": "V-type proton ATPase 21 kDa proteolipid subunit c''", "gene_name": "ATP6V0B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PJI9-1", "protein_name": "GATOR2 complex protein WDR59", "gene_name": "WDR59", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 133, "end_pos": 133, "sequence_org": "T", "sequence_mut": "W", "comment": "Abolishes arginine transport. No effect on subcellular location and interaction with Ragulator complex.", "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" }, { "database": "PubMed", "id": "29053970", "url": "https://pubmed.ncbi.nlm.nih.gov/29053970" } ], "uniprot_canonical_ac": "Q8NBW4-1" }, { "start_pos": 68, "end_pos": 68, "sequence_org": "I", "sequence_mut": "A", "comment": "Abolishes association with the Ragulator complex. No effect on amino acid transport activity. Abolishes the interaction with the Rag GTPases heterodimer complex.", "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" }, { "database": "PubMed", "id": "25567906", "url": "https://pubmed.ncbi.nlm.nih.gov/25567906" }, { "database": "PubMed", "id": "32868926", "url": "https://pubmed.ncbi.nlm.nih.gov/32868926" }, { "database": "PubMed", "id": "29053970", "url": "https://pubmed.ncbi.nlm.nih.gov/29053970" } ], "uniprot_canonical_ac": "Q8NBW4-1" } ], "record_id": "pubmed.29053970", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 56 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", 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"field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { 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"tax_name": "Human" }, { "uniprot_canonical_ac": "Q96S15-1", "protein_name": "GATOR2 complex protein WDR24", "gene_name": "WDR24", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21283-1", "protein_name": "V-type proton ATPase subunit C 1", "gene_name": "ATP6V1C1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQL2-1", "protein_name": "Ras-related GTP-binding protein D", "gene_name": "RRAGD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HB90-1", "protein_name": "Ras-related GTP-binding protein C", "gene_name": "RRAGC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9P0V3-1", "protein_name": "SH3 domain-binding protein 4", "gene_name": "SH3BP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75348-1", "protein_name": "V-type proton ATPase subunit G 1", "gene_name": "ATP6V1G1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y664-1", "protein_name": "KICSTOR complex protein kaptin", "gene_name": "KPTN", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"tax_name": "Human" }, { "uniprot_canonical_ac": "Q969R8-1", "protein_name": "KICSTOR complex protein ITFG2", "gene_name": "ITFG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VZM2-1", "protein_name": "Ras-related GTP-binding protein B", "gene_name": "RRAGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NEY4-1", "protein_name": "V-type proton ATPase subunit C 2", "gene_name": "ATP6V1C2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5T011-1", "protein_name": "KICSTOR complex protein SZT2", "gene_name": "SZT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5K8-1", "protein_name": "V-type proton ATPase subunit D", "gene_name": "ATP6V1D", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N8Y2-1", "protein_name": "V-type proton ATPase subunit d 2", "gene_name": "ATP6V0D2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15313-1", "protein_name": "V-type proton ATPase subunit B, kidney isoform", "gene_name": "ATP6V1B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6IAA8-1", "protein_name": "Ragulator complex protein LAMTOR1", "gene_name": "LAMTOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BVC4-1", "protein_name": "Target of rapamycin complex subunit LST8", "gene_name": "MLST8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q0VGL1-1", "protein_name": "Ragulator complex protein LAMTOR4", "gene_name": "LAMTOR4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43504-1", "protein_name": "Ragulator complex protein LAMTOR5", "gene_name": "LAMTOR5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7L523-1", "protein_name": "Ras-related GTP-binding protein A", "gene_name": "RRAGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N122-1", "protein_name": "Regulatory-associated protein of mTOR", "gene_name": "RPTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42345-1", "protein_name": "Serine/threonine-protein kinase mTOR", "gene_name": "MTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PJI9-1", "protein_name": "GATOR2 complex protein WDR59", "gene_name": "WDR59", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.29056322", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 55 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": 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"KICSTOR subunit 2", "gene_name": "KICS2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12980-1", "protein_name": "GATOR1 complex protein NPRL3", "gene_name": "NPRL3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WTW4-1", "protein_name": "GATOR1 complex protein NPRL2", "gene_name": "NPRL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96EE3-2", "protein_name": "Nucleoporin SEH1", "gene_name": "SEH1L", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55735-1", "protein_name": "Protein SEC13 homolog", "gene_name": "SEC13", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6P5-1", "protein_name": "Sestrin-1", "gene_name": "SESN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "A6NHX0-1", "protein_name": "Cytosolic arginine sensor for mTORC1 subunit 2", "gene_name": "CASTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WTX7-1", "protein_name": "Cytosolic arginine sensor for mTORC1 subunit 1", "gene_name": "CASTOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q969R8-1", "protein_name": "KICSTOR complex protein ITFG2", "gene_name": "ITFG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VZM2-1", "protein_name": "Ras-related GTP-binding protein B", "gene_name": "RRAGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NEY4-1", "protein_name": "V-type proton ATPase subunit C 2", "gene_name": "ATP6V1C2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5T011-1", "protein_name": "KICSTOR complex protein SZT2", "gene_name": "SZT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5K8-1", "protein_name": "V-type proton ATPase subunit D", "gene_name": "ATP6V1D", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N8Y2-1", "protein_name": "V-type proton ATPase subunit d 2", "gene_name": "ATP6V0D2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15313-1", "protein_name": "V-type proton ATPase subunit B, kidney isoform", "gene_name": "ATP6V1B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6IAA8-1", "protein_name": "Ragulator complex protein LAMTOR1", "gene_name": "LAMTOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BVC4-1", "protein_name": "Target of rapamycin complex subunit LST8", "gene_name": "MLST8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q0VGL1-1", "protein_name": "Ragulator complex protein LAMTOR4", "gene_name": "LAMTOR4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43504-1", "protein_name": "Ragulator complex protein LAMTOR5", "gene_name": "LAMTOR5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7L523-1", "protein_name": "Ras-related GTP-binding protein A", "gene_name": "RRAGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N122-1", "protein_name": "Regulatory-associated protein of mTOR", "gene_name": "RPTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42345-1", "protein_name": "Serine/threonine-protein kinase mTOR", "gene_name": "MTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96A05-1", "protein_name": "V-type proton ATPase subunit E 2", "gene_name": "ATP6V1E2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TF40-1", "protein_name": "Folliculin-interacting protein 1", "gene_name": "FNIP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFG4-1", "protein_name": "Folliculin", "gene_name": "FLCN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9P278-1", "protein_name": "Folliculin-interacting protein 2", "gene_name": "FNIP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NHE4-1", "protein_name": "V-type proton ATPase subunit e 2", "gene_name": "ATP6V0E2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q1RMZ1-1", "protein_name": "S-adenosylmethionine sensor upstream of mTORC1", "gene_name": "SAMTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75140-10", "protein_name": "GATOR1 complex protein DEPDC5", "gene_name": "DEPDC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15382-1", "protein_name": "GTP-binding protein Rheb", "gene_name": "RHEB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21281-1", "protein_name": "V-type proton ATPase subunit B, brain isoform", "gene_name": "ATP6V1B2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UI12-1", "protein_name": "V-type proton ATPase subunit H", "gene_name": "ATP6V1H", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13488-1", "protein_name": "V-type proton ATPase 116 kDa subunit a 3", "gene_name": "TCIRG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15342-1", "protein_name": "V-type proton ATPase subunit e 1", "gene_name": "ATP6V0E1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16864-1", "protein_name": "V-type proton ATPase subunit F", "gene_name": "ATP6V1F", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96LB4-1", "protein_name": "V-type proton ATPase subunit G 3", "gene_name": "ATP6V1G3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27449-1", "protein_name": "V-type proton ATPase 16 kDa proteolipid subunit c", "gene_name": "ATP6V0C", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NXC5-1", "protein_name": "GATOR2 complex protein MIOS", "gene_name": "MIOS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61421-1", "protein_name": "V-type proton ATPase subunit d 1", "gene_name": "ATP6V0D1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95670-1", "protein_name": "V-type proton ATPase subunit G 2", "gene_name": "ATP6V1G2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36543-1", "protein_name": "V-type proton ATPase subunit E 1", "gene_name": "ATP6V1E1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38606-1", "protein_name": "V-type proton ATPase catalytic subunit A", "gene_name": "ATP6V1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99437-1", "protein_name": "V-type proton ATPase 21 kDa proteolipid subunit c''", "gene_name": "ATP6V0B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PJI9-1", "protein_name": "GATOR2 complex protein WDR59", "gene_name": "WDR59", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9W1K5-1", "protein_name": "Sestrin homolog", "gene_name": "Sesn", "tax_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9W138-1", "protein_name": "Probable S-adenosyl-L-methionine-dependent methyltransferase", "gene_name": "CG3570", "tax_name": "Fruit fly" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.29123071", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 57 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", 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{ "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.", "journal": "Nature", "date": "2017", "authors": "Yang H, Jiang X, Li B, Yang HJ, Miller M, Yang A, Dhar A, Pavletich NP", "reference": { "type": "PubMed", "id": "29236692", "url": "https://pubmed.ncbi.nlm.nih.gov/29236692" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NBW4-1", "protein_name": "Neutral amino acid transporter 9", "gene_name": "SLC38A9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": 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"tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VZM2-1", "protein_name": "Ras-related GTP-binding protein B", "gene_name": "RRAGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NEY4-1", "protein_name": "V-type proton ATPase subunit C 2", "gene_name": "ATP6V1C2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5T011-1", "protein_name": "KICSTOR complex protein SZT2", "gene_name": "SZT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5K8-1", "protein_name": "V-type proton ATPase subunit D", "gene_name": "ATP6V1D", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N8Y2-1", "protein_name": "V-type proton ATPase subunit d 2", "gene_name": "ATP6V0D2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15313-1", "protein_name": "V-type proton ATPase subunit B, kidney isoform", "gene_name": "ATP6V1B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6IAA8-1", "protein_name": "Ragulator complex protein LAMTOR1", "gene_name": "LAMTOR1", "tax_name": "Human" }, { 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}, { "uniprot_canonical_ac": "Q9UKV8-1", "protein_name": "Protein argonaute-2", "gene_name": "AGO2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42345-1", "protein_name": "Serine/threonine-protein kinase mTOR", "gene_name": "MTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31751-1", "protein_name": "RAC-beta serine/threonine-protein kinase", "gene_name": "AKT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H9G7-1", "protein_name": "Protein argonaute-3", "gene_name": "AGO3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NDV7-1", "protein_name": "Trinucleotide repeat-containing gene 6A protein", "gene_name": "TNRC6A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96A05-1", "protein_name": "V-type proton ATPase subunit E 2", "gene_name": "ATP6V1E2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TF40-1", "protein_name": "Folliculin-interacting protein 1", "gene_name": "FNIP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFG4-1", 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"uniprot_canonical_ac": "Q8NHE4-1", "protein_name": "V-type proton ATPase subunit e 2", "gene_name": "ATP6V0E2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q1RMZ1-1", "protein_name": "S-adenosylmethionine sensor upstream of mTORC1", "gene_name": "SAMTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75140-10", "protein_name": "GATOR1 complex protein DEPDC5", "gene_name": "DEPDC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15382-1", "protein_name": "GTP-binding protein Rheb", "gene_name": "RHEB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21281-1", "protein_name": "V-type proton ATPase subunit B, brain isoform", "gene_name": "ATP6V1B2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UI12-1", "protein_name": "V-type proton ATPase subunit H", "gene_name": "ATP6V1H", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13488-1", "protein_name": "V-type proton ATPase 116 kDa subunit a 3", "gene_name": "TCIRG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15342-1", "protein_name": "V-type proton ATPase subunit e 1", "gene_name": "ATP6V0E1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16864-1", "protein_name": "V-type proton ATPase subunit F", "gene_name": "ATP6V1F", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96LB4-1", "protein_name": "V-type proton ATPase subunit G 3", "gene_name": "ATP6V1G3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27449-1", "protein_name": "V-type proton ATPase 16 kDa proteolipid subunit c", "gene_name": "ATP6V0C", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NXC5-1", "protein_name": "GATOR2 complex protein MIOS", "gene_name": "MIOS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61421-1", "protein_name": "V-type proton ATPase subunit d 1", "gene_name": "ATP6V0D1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95670-1", "protein_name": "V-type proton ATPase subunit G 2", "gene_name": "ATP6V1G2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36543-1", "protein_name": "V-type proton ATPase subunit E 1", "gene_name": "ATP6V1E1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38606-1", "protein_name": "V-type proton ATPase catalytic subunit A", "gene_name": "ATP6V1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99437-1", "protein_name": "V-type proton ATPase 21 kDa proteolipid subunit c''", "gene_name": "ATP6V0B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PJI9-1", "protein_name": "GATOR2 complex protein WDR59", "gene_name": "WDR59", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.30181260", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 55 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases.", "journal": "The Journal of biological chemistry", "date": "2019", "authors": "Shen K, Valenstein ML, Gu X, Sabatini DM", "reference": { "type": "PubMed", "id": "30651352", "url": "https://pubmed.ncbi.nlm.nih.gov/30651352" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NBW4-1", "protein_name": "Neutral amino acid transporter 9", "gene_name": "SLC38A9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P58004-1", "protein_name": "Sestrin-2", "gene_name": "SESN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96S15-1", "protein_name": "GATOR2 complex protein WDR24", "gene_name": "WDR24", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21283-1", "protein_name": "V-type proton ATPase subunit C 1", "gene_name": "ATP6V1C1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQL2-1", "protein_name": "Ras-related GTP-binding protein D", "gene_name": "RRAGD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HB90-1", "protein_name": "Ras-related GTP-binding protein C", "gene_name": 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"Human" }, { "uniprot_canonical_ac": "Q9Y5K8-1", "protein_name": "V-type proton ATPase subunit D", "gene_name": "ATP6V1D", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N8Y2-1", "protein_name": "V-type proton ATPase subunit d 2", "gene_name": "ATP6V0D2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15313-1", "protein_name": "V-type proton ATPase subunit B, kidney isoform", "gene_name": "ATP6V1B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6IAA8-1", "protein_name": "Ragulator complex protein LAMTOR1", "gene_name": "LAMTOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BVC4-1", "protein_name": "Target of rapamycin complex subunit LST8", "gene_name": "MLST8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q0VGL1-1", "protein_name": "Ragulator complex protein LAMTOR4", "gene_name": "LAMTOR4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43504-1", "protein_name": "Ragulator complex protein LAMTOR5", "gene_name": "LAMTOR5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7L523-1", "protein_name": "Ras-related GTP-binding protein A", "gene_name": "RRAGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N122-1", "protein_name": "Regulatory-associated protein of mTOR", "gene_name": "RPTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42345-1", "protein_name": "Serine/threonine-protein kinase mTOR", "gene_name": "MTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96A05-1", "protein_name": "V-type proton ATPase subunit E 2", "gene_name": "ATP6V1E2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TF40-1", "protein_name": "Folliculin-interacting protein 1", "gene_name": "FNIP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFG4-1", "protein_name": "Folliculin", "gene_name": "FLCN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9P278-1", "protein_name": "Folliculin-interacting protein 2", "gene_name": "FNIP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NHE4-1", "protein_name": "V-type proton ATPase subunit e 2", "gene_name": "ATP6V0E2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q1RMZ1-1", "protein_name": "S-adenosylmethionine sensor upstream of mTORC1", "gene_name": "SAMTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75140-10", "protein_name": "GATOR1 complex protein DEPDC5", "gene_name": "DEPDC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15382-1", "protein_name": "GTP-binding protein Rheb", "gene_name": "RHEB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21281-1", "protein_name": "V-type proton ATPase subunit B, brain isoform", "gene_name": "ATP6V1B2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UI12-1", "protein_name": "V-type proton ATPase subunit H", "gene_name": "ATP6V1H", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13488-1", "protein_name": "V-type proton ATPase 116 kDa subunit a 3", 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"tax_name": "Human" }, { "uniprot_canonical_ac": "P36543-1", "protein_name": "V-type proton ATPase subunit E 1", "gene_name": "ATP6V1E1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38606-1", "protein_name": "V-type proton ATPase catalytic subunit A", "gene_name": "ATP6V1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99437-1", "protein_name": "V-type proton ATPase 21 kDa proteolipid subunit c''", "gene_name": "ATP6V0B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PJI9-1", "protein_name": "GATOR2 complex protein WDR59", "gene_name": "WDR59", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 117, "end_pos": 121, "sequence_org": "SFVSM", "sequence_mut": "GSGSG", "comment": "In RL2 mutant; does not 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"tax_name": "Human" }, { "uniprot_canonical_ac": "Q92574-1", "protein_name": "Hamartin", "gene_name": "TSC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H3D4-1", "protein_name": "Tumor protein 63", "gene_name": "TP63", "tax_name": "Human" }, { "uniprot_canonical_ac": "P10599-1", "protein_name": "Thioredoxin", "gene_name": "TXN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14406-1", "protein_name": "Cytochrome c oxidase subunit 7A2, mitochondrial", "gene_name": "COX7A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24310-1", "protein_name": "Cytochrome c oxidase subunit 7A1, mitochondrial", "gene_name": "COX7A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VZM2-1", "protein_name": "Ras-related GTP-binding protein B", "gene_name": "RRAGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P32119-1", "protein_name": "Peroxiredoxin-2", "gene_name": "PRDX2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24311-1", "protein_name": "Cytochrome c oxidase 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"gene_name": "LAMTOR4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43504-1", "protein_name": "Ragulator complex protein LAMTOR5", "gene_name": "LAMTOR5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q7L523-1", "protein_name": "Ras-related GTP-binding protein A", "gene_name": "RRAGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31947-1", "protein_name": "14-3-3 protein sigma", "gene_name": "SFN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N122-1", "protein_name": "Regulatory-associated protein of mTOR", "gene_name": "RPTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31749-1", "protein_name": "RAC-alpha serine/threonine-protein kinase", "gene_name": "AKT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UGI9-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-3", "gene_name": "PRKAG3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UKV8-1", "protein_name": "Protein argonaute-2", "gene_name": "AGO2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42345-1", "protein_name": "Serine/threonine-protein kinase mTOR", "gene_name": "MTOR", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31751-1", "protein_name": "RAC-beta serine/threonine-protein kinase", "gene_name": "AKT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06830-1", "protein_name": "Peroxiredoxin-1", "gene_name": "PRDX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H9G7-1", "protein_name": "Protein argonaute-3", "gene_name": "AGO3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NDV7-1", "protein_name": "Trinucleotide repeat-containing gene 6A protein", "gene_name": "TNRC6A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00395-1", "protein_name": "Cytochrome c oxidase subunit 1", "gene_name": "MT-CO1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00414-1", "protein_name": "Cytochrome c oxidase subunit 3", "gene_name": "MT-CO3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96KJ9-1", "protein_name": "Cytochrome c oxidase subunit 4 isoform 2, mitochondrial", "gene_name": "COX4I2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14548-1", "protein_name": "Cytochrome c oxidase subunit 7A2-like, mitochondrial", "gene_name": "COX7A2L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q02221-1", "protein_name": "Cytochrome c oxidase subunit 6A2, mitochondrial", "gene_name": "COX6A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00403-1", "protein_name": "Cytochrome c oxidase subunit 2", "gene_name": "MT-CO2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P10176-1", "protein_name": "Cytochrome c oxidase subunit 8A, mitochondrial", "gene_name": "COX8A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12074-1", "protein_name": "Cytochrome c oxidase subunit 6A1, mitochondrial", "gene_name": "COX6A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14854-1", "protein_name": "Cytochrome c oxidase subunit 6B1", "gene_name": "COX6B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06744-1", "protein_name": "Glucose-6-phosphate isomerase", "gene_name": "GPI", "tax_name": "Human" }, { "uniprot_canonical_ac": "P11413-1", "protein_name": "Glucose-6-phosphate 1-dehydrogenase", "gene_name": "G6PD", "tax_name": "Human" }, { "uniprot_canonical_ac": "P10606-1", "protein_name": "Cytochrome c oxidase subunit 5B, mitochondrial", "gene_name": "COX5B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P60484-1", "protein_name": "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN", "gene_name": "PTEN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HCE1-1", "protein_name": "RNA helicase MOV-10", "gene_name": "MOV10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2Q5-1", "protein_name": "Ragulator complex protein LAMTOR2", "gene_name": "LAMTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15382-1", "protein_name": "GTP-binding protein Rheb", "gene_name": "RHEB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NX09-1", "protein_name": "DNA damage-inducible transcript 4 protein", "gene_name": "DDIT4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49815-1", "protein_name": "Tuberin", "gene_name": "TSC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62258-1", "protein_name": "14-3-3 protein epsilon", "gene_name": "YWHAE", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63104-1", "protein_name": "14-3-3 protein zeta/delta", "gene_name": "YWHAZ", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54619-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-1", "gene_name": "PRKAG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04917-1", "protein_name": "14-3-3 protein eta", "gene_name": "YWHAH", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43741-1", "protein_name": "5'-AMP-activated protein kinase subunit beta-2", "gene_name": "PRKAB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31946-1", "protein_name": "14-3-3 protein beta/alpha", "gene_name": "YWHAB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13131-1", "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-1", "gene_name": "PRKAA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27348-1", "protein_name": "14-3-3 protein theta", "gene_name": "YWHAQ", "tax_name": "Human" }, { "uniprot_canonical_ac": "P54646-1", "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-2", "gene_name": "PRKAA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61981-1", "protein_name": "14-3-3 protein gamma", "gene_name": "YWHAG", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UGJ0-1", "protein_name": "5'-AMP-activated protein kinase subunit gamma-2", "gene_name": "PRKAG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y478-1", "protein_name": "5'-AMP-activated protein kinase subunit beta-1", "gene_name": "PRKAB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04637-1", "protein_name": "Cellular tumor antigen p53", "gene_name": "TP53", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q8NBW4", "url": "https://www.uniprot.org/uniprotkb/Q8NBW4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.5666113", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 81 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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"count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Schurmann A, Brauers A, Massmann S, Becker W, Joost HG", "reference": { "type": "PubMed", "id": "7499430", "url": "https://pubmed.ncbi.nlm.nih.gov/7499430" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NBW4-1", "protein_name": "Neutral amino acid transporter 9", "gene_name": "SLC38A9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P58004-1", "protein_name": "Sestrin-2", "gene_name": "SESN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96S15-1", "protein_name": "GATOR2 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{ "uniprot_canonical_ac": "Q12980-1", "protein_name": "GATOR1 complex protein NPRL3", "gene_name": "NPRL3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WTW4-1", "protein_name": "GATOR1 complex protein NPRL2", "gene_name": "NPRL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96EE3-2", "protein_name": "Nucleoporin SEH1", "gene_name": "SEH1L", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55735-1", "protein_name": "Protein SEC13 homolog", "gene_name": "SEC13", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6P5-1", "protein_name": "Sestrin-1", "gene_name": "SESN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "A6NHX0-1", "protein_name": "Cytosolic arginine sensor for mTORC1 subunit 2", "gene_name": "CASTOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WTX7-1", "protein_name": "Cytosolic arginine sensor for mTORC1 subunit 1", "gene_name": "CASTOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q969R8-1", "protein_name": "KICSTOR complex protein 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"o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC.", "journal": "FEBS letters", "date": "1995", "authors": "Davies SP, Helps NR, Cohen PT, Hardie DG", "reference": { "type": "PubMed", "id": "8549768", "url": "https://pubmed.ncbi.nlm.nih.gov/8549768" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NBW4-1", "protein_name": "Neutral amino acid transporter 9", "gene_name": "SLC38A9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35813-1", "protein_name": "Protein phosphatase 1A", "gene_name": "PPM1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQL2-1", "protein_name": "Ras-related GTP-binding protein D", "gene_name": "RRAGD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HB90-1", "protein_name": "Ras-related GTP-binding protein C", 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rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression.", "journal": "Clinical biochemistry", "date": "1998", "authors": "Sehgal SN", "reference": { "type": "PubMed", "id": "9721431", "url": "https://pubmed.ncbi.nlm.nih.gov/9721431" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q8NBW4-1", "protein_name": "Neutral amino acid transporter 9", "gene_name": "SLC38A9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UHA4-1", "protein_name": "Ragulator complex protein LAMTOR3", "gene_name": "LAMTOR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQL2-1", "protein_name": "Ras-related GTP-binding protein D", "gene_name": "RRAGD", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HB90-1", "protein_name": "Ras-related GTP-binding protein C", "gene_name": "RRAGC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5VZM2-1", "protein_name": "Ras-related 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"o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Targeted capture sequencing identifies genetic variations of GRK4 and RDH8 in Han Chinese with essential hypertension in Xinjiang.", "journal": "PloS one", "date": "2021", "authors": "Jiang W, Wang X, Li R, Wang P, Shan G, Jia X, Gu M", "reference": { "type": "PubMed", "id": "34297769", "url": "https://pubmed.ncbi.nlm.nih.gov/34297769" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9NYR8-1", "protein_name": "Retinol dehydrogenase 8", "gene_name": "RDH8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P32298-1", "protein_name": "G protein-coupled receptor kinase 4", "gene_name": "GRK4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NYR8", "url": "https://www.uniprot.org/uniprotkb/Q9NYR8" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], 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Ferese Rosangela, Gambardella Stefano, Cascella Raffaella, Sebastiani Jacopo, Falsini Benedetto, Cusumano Andrea, Giardina Emiliano", "reference": { "type": "PubMed", "id": "37628710", "url": "https://pubmed.ncbi.nlm.nih.gov/37628710" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9NYR8-1", "protein_name": "Retinol dehydrogenase 8", "gene_name": "RDH8", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NYR8", "url": "https://www.uniprot.org/uniprotkb/Q9NYR8" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.37628710", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", 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Role in complex formation with insulin-like growth factor (IGF)-binding protein-3 and the IGFs.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Janosi JB, Firth SM, Bond JJ, Baxter RC, Delhanty PJ", "reference": { "type": "PubMed", "id": "10026136", "url": "https://pubmed.ncbi.nlm.nih.gov/10026136" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q14766-1", "protein_name": "Latent-transforming growth factor beta-binding protein 1", "gene_name": "LTBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q24JP5-1", "protein_name": "Transmembrane protein 132A", "gene_name": "TMEM132A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00734-1", "protein_name": "Prothrombin", "gene_name": "F2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99217-1", "protein_name": "Amelogenin, X isoform", "gene_name": "AMELX", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02671-1", "protein_name": "Fibrinogen alpha chain", 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"Human" }, { "uniprot_canonical_ac": "P19823-1", "protein_name": "Inter-alpha-trypsin inhibitor heavy chain H2", "gene_name": "ITIH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13103-1", "protein_name": "Secreted phosphoprotein 24", "gene_name": "SPP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15240-1", "protein_name": "Neurosecretory protein VGF", "gene_name": "VGF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BU40-6", "protein_name": "Chordin-like protein 1", "gene_name": "CHRDL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24593-1", "protein_name": "Insulin-like growth factor-binding protein 5", "gene_name": "IGFBP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14703-1", "protein_name": "Membrane-bound transcription factor site-1 protease", "gene_name": "MBTPS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BXP8-1", "protein_name": "Pappalysin-2", "gene_name": "PAPPA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02652-1", "protein_name": "Apolipoprotein A-II", "gene_name": "APOA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NBP7-1", "protein_name": "Proprotein convertase subtilisin/kexin type 9", "gene_name": "PCSK9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IXL6-1", "protein_name": "Extracellular serine/threonine protein kinase FAM20C", "gene_name": "FAM20C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35858-1", "protein_name": "Insulin-like growth factor-binding protein complex acid labile subunit", "gene_name": "IGFALS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6Q788-1", "protein_name": "Apolipoprotein A-V", "gene_name": "APOA5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00747-1", "protein_name": "Plasminogen", "gene_name": "PLG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02768-1", "protein_name": "Albumin", "gene_name": "ALB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07288-1", "protein_name": "Prostate-specific antigen", "gene_name": "KLK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NP70-1", "protein_name": "Ameloblastin", "gene_name": "AMBN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5JRA6-1", "protein_name": "Transport and Golgi organization protein 1 homolog", "gene_name": "MIA3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04070-1", "protein_name": "Vitamin K-dependent protein C", "gene_name": "PROC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P34741-1", "protein_name": "Syndecan-2", "gene_name": "SDC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01034-1", "protein_name": "Cystatin-C", "gene_name": "CST3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H8M9-1", "protein_name": "Protein eva-1 homolog A", "gene_name": "EVA1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12259-1", "protein_name": "Coagulation factor V", "gene_name": "F5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NRM1-1", "protein_name": "Enamelin", "gene_name": "ENAM", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BTY2-1", "protein_name": "Plasma alpha-L-fucosidase", "gene_name": "FUCA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02787-1", "protein_name": "Serotransferrin", "gene_name": "TF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UK55-1", "protein_name": "Protein Z-dependent protease inhibitor", "gene_name": "SERPINA10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13611-1", "protein_name": "Versican core protein", "gene_name": "VCAN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86UP2-1", "protein_name": "Kinectin", "gene_name": "KTN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01042-1", "protein_name": "Kininogen-1", "gene_name": "KNG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12644-1", "protein_name": "Bone morphogenetic protein 4", "gene_name": "BMP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95972-1", "protein_name": "Bone morphogenetic protein 15", "gene_name": "BMP15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N4F0-1", "protein_name": "BPI fold-containing family B member 2", "gene_name": "BPIFB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19022-1", "protein_name": "Cadherin-2", "gene_name": "CDH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43852-1", "protein_name": "Calumenin", "gene_name": "CALU", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14515-1", "protein_name": "SPARC-like protein 1", "gene_name": "SPARCL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08253-1", "protein_name": "72 kDa type IV collagenase", "gene_name": "MMP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BRK3-1", "protein_name": "Matrix remodeling-associated protein 8", "gene_name": "MXRA8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16270-1", "protein_name": "Insulin-like growth factor-binding protein 7", "gene_name": "IGFBP7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96AD5-1", "protein_name": "Patatin-like phospholipase domain-containing protein 2", "gene_name": "PNPLA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05546-1", "protein_name": "Heparin cofactor 2", "gene_name": "SERPIND1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95084-1", "protein_name": "Serine protease 23", "gene_name": "PRSS23", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00391-1", "protein_name": "Sulfhydryl oxidase 1", "gene_name": "QSOX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15084-1", "protein_name": "Protein disulfide-isomerase A6", "gene_name": "PDIA6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15232-1", "protein_name": "Matrilin-3", "gene_name": "MATN3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76061-1", "protein_name": "Stanniocalcin-2", "gene_name": "STC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08582-1", "protein_name": "Melanotransferrin", "gene_name": "MELTF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N114-1", "protein_name": "Protein shisa-5", "gene_name": "SHISA5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09382-1", "protein_name": "Galectin-1", "gene_name": "LGALS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15293-1", "protein_name": "Reticulocalbin-1", "gene_name": "RCN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01024-1", "protein_name": "Complement C3", "gene_name": "C3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00255-2", "protein_name": "Menin", "gene_name": "MEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13316-1", "protein_name": "Dentin matrix acidic phosphoprotein 1", "gene_name": "DMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13217-1", "protein_name": "DnaJ homolog subfamily C member 3", "gene_name": "DNAJC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35555-1", "protein_name": "Fibrillin-1", "gene_name": "FBN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05060-1", "protein_name": "Secretogranin-1", "gene_name": "CHGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08833-1", "protein_name": "Insulin-like growth factor-binding protein 1", "gene_name": "IGFBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14314-1", "protein_name": "Glucosidase 2 subunit beta", "gene_name": "PRKCSH", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20718-1", "protein_name": "Granzyme H", "gene_name": "GZMH", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9GZV9-1", "protein_name": "Fibroblast growth factor 23", "gene_name": "FGF23", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18065-1", "protein_name": "Insulin-like growth factor-binding protein 2", "gene_name": "IGFBP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01344-1", "protein_name": "Insulin-like growth factor 2", "gene_name": "IGF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MK3-1", "protein_name": "Pseudokinase FAM20A", "gene_name": "FAM20A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05019-1", "protein_name": "Insulin-like growth factor 1", "gene_name": "IGF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24592-1", "protein_name": "Insulin-like growth factor-binding protein 6", "gene_name": "IGFBP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22692-1", "protein_name": "Insulin-like growth factor-binding protein 4", "gene_name": "IGFBP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08431-1", "protein_name": "Lactadherin", "gene_name": "MFGE8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55268-1", "protein_name": "Laminin subunit beta-2", "gene_name": "LAMB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ76-1", "protein_name": "Matrix extracellular phosphoglycoprotein", "gene_name": "MEPE", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM21-1", "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A", "gene_name": "MGAT4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24821-1", "protein_name": "Tenascin", "gene_name": "TNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76024-1", "protein_name": "Wolframin", "gene_name": "WFS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02771-1", "protein_name": "Alpha-fetoprotein", "gene_name": "AFP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14625-1", "protein_name": "Endoplasmin", "gene_name": "HSP90B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB0-1", "protein_name": "von Willebrand factor A domain-containing protein 1", "gene_name": "VWA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05067-1", "protein_name": "Amyloid-beta precursor protein", "gene_name": "APP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06481-1", "protein_name": "Amyloid beta precursor like protein 2", "gene_name": "APLP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14672-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02647-1", "protein_name": "Apolipoprotein A-I", "gene_name": "APOA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01009-1", "protein_name": "Alpha-1-antitrypsin", "gene_name": "SERPINA1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q14766", "url": "https://www.uniprot.org/uniprotkb/Q14766" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10026136", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 124 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1999", "authors": "Lawrence JB, Oxvig C, Overgaard MT, Sottrup-Jensen L, Gleich GJ, Hays LG, Yates JR 3rd, Conover CA", "reference": { "type": "PubMed", "id": "10077652", "url": "https://pubmed.ncbi.nlm.nih.gov/10077652" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q14766-1", "protein_name": "Latent-transforming growth factor beta-binding protein 1", "gene_name": "LTBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q24JP5-1", "protein_name": "Transmembrane protein 132A", "gene_name": "TMEM132A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00734-1", "protein_name": "Prothrombin", "gene_name": "F2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99217-1", "protein_name": "Amelogenin, X isoform", "gene_name": "AMELX", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02671-1", "protein_name": "Fibrinogen alpha chain", "gene_name": "FGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12841-1", "protein_name": "Follistatin-related protein 1", "gene_name": "FSTL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95633-1", "protein_name": "Follistatin-related protein 3", "gene_name": "FSTL3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14791-1", "protein_name": "Apolipoprotein L1", "gene_name": "APOL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HCE9-1", "protein_name": "Anoctamin-8", "gene_name": "ANO8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04114-1", "protein_name": "Apolipoprotein B-100", "gene_name": "APOB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02751-15", "protein_name": "Fibronectin", "gene_name": "FN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01008-1", "protein_name": "Antithrombin-III", "gene_name": "SERPINC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UX39-1", "protein_name": "Amelotin", "gene_name": "AMTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01210-1", "protein_name": "Proenkephalin-A", "gene_name": "PENK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q02818-1", "protein_name": "Nucleobindin-1", "gene_name": "NUCB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07065-1", "protein_name": "Cytoskeleton-associated protein 4", "gene_name": "CKAP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02765-1", "protein_name": "Alpha-2-HS-glycoprotein", "gene_name": "AHSG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02679-1", "protein_name": "Fibrinogen gamma chain", "gene_name": "FGG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07237-1", "protein_name": "Protein disulfide-isomerase", "gene_name": "P4HB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14393-2", "protein_name": "Growth arrest-specific protein 6", "gene_name": "GAS6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P51654-1", "protein_name": "Glypican-3", "gene_name": "GPC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NBJ4-1", "protein_name": "Golgi membrane protein 1", "gene_name": "GOLM1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09603-1", "protein_name": "Macrophage colony-stimulating factor 1", "gene_name": "CSF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05231-1", "protein_name": "Interleukin-6", "gene_name": "IL6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6P988-1", "protein_name": "Palmitoleoyl-protein carboxylesterase NOTUM", "gene_name": "NOTUM", "tax_name": "Human" }, { "uniprot_canonical_ac": "P03956-1", "protein_name": "Interstitial collagenase", "gene_name": "MMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13421-3", "protein_name": "Mesothelin", "gene_name": "MSLN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13219-1", "protein_name": "Pappalysin-1", "gene_name": "PAPPA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P23327-1", "protein_name": "Sarcoplasmic reticulum histidine-rich calcium-binding protein", "gene_name": "HRC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WXD2-1", "protein_name": "Secretogranin-3", "gene_name": "SCG3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01033-1", "protein_name": "Metalloproteinase inhibitor 1", "gene_name": "TIMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P17936-1", "protein_name": "Insulin-like growth factor-binding protein 3", "gene_name": "IGFBP3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02649-1", "protein_name": "Apolipoprotein E", "gene_name": "APOE", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13521-1", "protein_name": "Secretogranin-2", "gene_name": "SCG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08311-1", "protein_name": "Cathepsin G", "gene_name": "CTSG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00450-1", "protein_name": "Ceruloplasmin", "gene_name": "CP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P10451-1", "protein_name": "Osteopontin", "gene_name": "SPP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0C0L4-1", "protein_name": "Complement C4-A", "gene_name": "C4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00622-1", "protein_name": "CCN family member 1", "gene_name": "CCN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20151-1", "protein_name": "Kallikrein-2", "gene_name": "KLK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07942-1", "protein_name": "Laminin subunit beta-1", "gene_name": "LAMB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06870-1", "protein_name": "Kallikrein-1", "gene_name": "KLK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UKR3-1", "protein_name": "Kallikrein-13", "gene_name": "KLK13", "tax_name": "Human" }, { "uniprot_canonical_ac": "P11047-1", "protein_name": "Laminin subunit gamma-1", "gene_name": "LAMC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43493-2", "protein_name": "Trans-Golgi network integral membrane protein 2", "gene_name": "TGOLN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19823-1", "protein_name": "Inter-alpha-trypsin inhibitor heavy chain H2", "gene_name": "ITIH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13103-1", "protein_name": "Secreted phosphoprotein 24", "gene_name": "SPP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15240-1", "protein_name": "Neurosecretory protein VGF", "gene_name": "VGF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BU40-6", "protein_name": "Chordin-like protein 1", "gene_name": "CHRDL1", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"uniprot_canonical_ac": "Q6Q788-1", "protein_name": "Apolipoprotein A-V", "gene_name": "APOA5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00747-1", "protein_name": "Plasminogen", "gene_name": "PLG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02768-1", "protein_name": "Albumin", "gene_name": "ALB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07288-1", "protein_name": "Prostate-specific antigen", "gene_name": "KLK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NP70-1", "protein_name": "Ameloblastin", "gene_name": "AMBN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5JRA6-1", "protein_name": "Transport and Golgi organization protein 1 homolog", "gene_name": "MIA3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04070-1", "protein_name": "Vitamin K-dependent protein C", "gene_name": "PROC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P34741-1", "protein_name": "Syndecan-2", "gene_name": "SDC2", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"protein_name": "Kinectin", "gene_name": "KTN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01042-1", "protein_name": "Kininogen-1", "gene_name": "KNG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12644-1", "protein_name": "Bone morphogenetic protein 4", "gene_name": "BMP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95972-1", "protein_name": "Bone morphogenetic protein 15", "gene_name": "BMP15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N4F0-1", "protein_name": "BPI fold-containing family B member 2", "gene_name": "BPIFB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19022-1", "protein_name": "Cadherin-2", "gene_name": "CDH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43852-1", "protein_name": "Calumenin", "gene_name": "CALU", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14515-1", "protein_name": "SPARC-like protein 1", "gene_name": "SPARCL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08253-1", "protein_name": "72 kDa 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"tax_name": "Human" }, { "uniprot_canonical_ac": "O15232-1", "protein_name": "Matrilin-3", "gene_name": "MATN3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76061-1", "protein_name": "Stanniocalcin-2", "gene_name": "STC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08582-1", "protein_name": "Melanotransferrin", "gene_name": "MELTF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N114-1", "protein_name": "Protein shisa-5", "gene_name": "SHISA5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09382-1", "protein_name": "Galectin-1", "gene_name": "LGALS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15293-1", "protein_name": "Reticulocalbin-1", "gene_name": "RCN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01024-1", "protein_name": "Complement C3", "gene_name": "C3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00255-2", "protein_name": "Menin", "gene_name": "MEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13316-1", "protein_name": "Dentin matrix acidic phosphoprotein 1", "gene_name": "DMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13217-1", "protein_name": "DnaJ homolog subfamily C member 3", "gene_name": "DNAJC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35555-1", "protein_name": "Fibrillin-1", "gene_name": "FBN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05060-1", "protein_name": "Secretogranin-1", "gene_name": "CHGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08833-1", "protein_name": "Insulin-like growth factor-binding protein 1", "gene_name": "IGFBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14314-1", "protein_name": "Glucosidase 2 subunit beta", "gene_name": "PRKCSH", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20718-1", "protein_name": "Granzyme H", "gene_name": "GZMH", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9GZV9-1", "protein_name": "Fibroblast growth factor 23", "gene_name": "FGF23", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18065-1", "protein_name": "Insulin-like growth factor-binding protein 2", "gene_name": "IGFBP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01344-1", "protein_name": "Insulin-like growth factor 2", "gene_name": "IGF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MK3-1", "protein_name": "Pseudokinase FAM20A", "gene_name": "FAM20A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05019-1", "protein_name": "Insulin-like growth factor 1", "gene_name": "IGF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24592-1", "protein_name": "Insulin-like growth factor-binding protein 6", "gene_name": "IGFBP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22692-1", "protein_name": "Insulin-like growth factor-binding protein 4", "gene_name": "IGFBP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08431-1", "protein_name": "Lactadherin", "gene_name": "MFGE8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55268-1", "protein_name": "Laminin subunit beta-2", "gene_name": "LAMB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ76-1", "protein_name": "Matrix extracellular phosphoglycoprotein", "gene_name": "MEPE", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM21-1", "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A", "gene_name": "MGAT4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24821-1", "protein_name": "Tenascin", "gene_name": "TNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76024-1", "protein_name": "Wolframin", "gene_name": "WFS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02771-1", "protein_name": "Alpha-fetoprotein", "gene_name": "AFP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14625-1", "protein_name": "Endoplasmin", "gene_name": "HSP90B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB0-1", "protein_name": "von Willebrand factor A domain-containing protein 1", "gene_name": "VWA1", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"Human" }, { "uniprot_canonical_ac": "P04070-1", "protein_name": "Vitamin K-dependent protein C", "gene_name": "PROC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P34741-1", "protein_name": "Syndecan-2", "gene_name": "SDC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01034-1", "protein_name": "Cystatin-C", "gene_name": "CST3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H8M9-1", "protein_name": "Protein eva-1 homolog A", "gene_name": "EVA1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12259-1", "protein_name": "Coagulation factor V", "gene_name": "F5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NRM1-1", "protein_name": "Enamelin", "gene_name": "ENAM", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BTY2-1", "protein_name": "Plasma alpha-L-fucosidase", "gene_name": "FUCA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02787-1", "protein_name": "Serotransferrin", "gene_name": "TF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UK55-1", "protein_name": "Protein Z-dependent protease inhibitor", "gene_name": "SERPINA10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13611-1", "protein_name": "Versican core protein", "gene_name": "VCAN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86UP2-1", "protein_name": "Kinectin", "gene_name": "KTN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01042-1", "protein_name": "Kininogen-1", "gene_name": "KNG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12644-1", "protein_name": "Bone morphogenetic protein 4", "gene_name": "BMP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95972-1", "protein_name": "Bone morphogenetic protein 15", "gene_name": "BMP15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N4F0-1", "protein_name": "BPI fold-containing family B member 2", "gene_name": "BPIFB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19022-1", "protein_name": "Cadherin-2", "gene_name": "CDH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43852-1", "protein_name": "Calumenin", "gene_name": "CALU", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14515-1", "protein_name": "SPARC-like protein 1", "gene_name": "SPARCL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08253-1", "protein_name": "72 kDa type IV collagenase", "gene_name": "MMP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BRK3-1", "protein_name": "Matrix remodeling-associated protein 8", "gene_name": "MXRA8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16270-1", "protein_name": "Insulin-like growth factor-binding protein 7", "gene_name": "IGFBP7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96AD5-1", "protein_name": "Patatin-like phospholipase domain-containing protein 2", "gene_name": "PNPLA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05546-1", "protein_name": "Heparin cofactor 2", "gene_name": "SERPIND1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95084-1", "protein_name": "Serine protease 23", "gene_name": "PRSS23", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00391-1", "protein_name": "Sulfhydryl oxidase 1", "gene_name": "QSOX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15084-1", "protein_name": "Protein disulfide-isomerase A6", "gene_name": "PDIA6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15232-1", "protein_name": "Matrilin-3", "gene_name": "MATN3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76061-1", "protein_name": "Stanniocalcin-2", "gene_name": "STC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08582-1", "protein_name": "Melanotransferrin", "gene_name": "MELTF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N114-1", "protein_name": "Protein shisa-5", "gene_name": "SHISA5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09382-1", "protein_name": "Galectin-1", "gene_name": "LGALS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15293-1", "protein_name": "Reticulocalbin-1", "gene_name": "RCN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01024-1", "protein_name": "Complement C3", "gene_name": "C3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00255-2", "protein_name": "Menin", "gene_name": "MEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13316-1", "protein_name": "Dentin matrix acidic phosphoprotein 1", "gene_name": "DMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13217-1", "protein_name": "DnaJ homolog subfamily C member 3", "gene_name": "DNAJC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35555-1", "protein_name": "Fibrillin-1", "gene_name": "FBN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05060-1", "protein_name": "Secretogranin-1", "gene_name": "CHGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08833-1", "protein_name": "Insulin-like growth factor-binding protein 1", "gene_name": "IGFBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14314-1", "protein_name": "Glucosidase 2 subunit beta", "gene_name": "PRKCSH", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20718-1", "protein_name": "Granzyme H", "gene_name": "GZMH", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9GZV9-1", "protein_name": "Fibroblast growth factor 23", "gene_name": "FGF23", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18065-1", "protein_name": "Insulin-like growth factor-binding protein 2", "gene_name": "IGFBP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01344-1", "protein_name": "Insulin-like growth factor 2", "gene_name": "IGF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MK3-1", "protein_name": "Pseudokinase FAM20A", "gene_name": "FAM20A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05019-1", "protein_name": "Insulin-like growth factor 1", "gene_name": "IGF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24592-1", "protein_name": "Insulin-like growth factor-binding protein 6", "gene_name": "IGFBP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22692-1", "protein_name": "Insulin-like growth factor-binding protein 4", "gene_name": "IGFBP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08431-1", "protein_name": "Lactadherin", "gene_name": "MFGE8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55268-1", "protein_name": "Laminin subunit beta-2", "gene_name": "LAMB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ76-1", "protein_name": "Matrix extracellular phosphoglycoprotein", "gene_name": "MEPE", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM21-1", "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A", "gene_name": "MGAT4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24821-1", "protein_name": "Tenascin", "gene_name": "TNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76024-1", "protein_name": "Wolframin", "gene_name": "WFS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02771-1", "protein_name": "Alpha-fetoprotein", "gene_name": "AFP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14625-1", "protein_name": "Endoplasmin", "gene_name": "HSP90B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB0-1", "protein_name": "von Willebrand factor A domain-containing protein 1", "gene_name": "VWA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05067-1", "protein_name": "Amyloid-beta precursor protein", "gene_name": "APP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06481-1", "protein_name": "Amyloid beta precursor like protein 2", "gene_name": "APLP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14672-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02647-1", "protein_name": "Apolipoprotein A-I", "gene_name": "APOA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01009-1", "protein_name": "Alpha-1-antitrypsin", "gene_name": "SERPINA1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q14766", "url": "https://www.uniprot.org/uniprotkb/Q14766" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10218588", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 124 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Inflammation-related neutrophil proteases, cathepsin G and elastase, function as insulin-like growth factor binding protein proteases.", "journal": "Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society", "date": "1999", "authors": "Gibson TL, Cohen P", "reference": { "type": "PubMed", "id": "10512690", "url": "https://pubmed.ncbi.nlm.nih.gov/10512690" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q14766-1", "protein_name": "Latent-transforming growth factor beta-binding protein 1", "gene_name": "LTBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q24JP5-1", "protein_name": "Transmembrane protein 132A", "gene_name": "TMEM132A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00734-1", "protein_name": "Prothrombin", "gene_name": "F2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99217-1", "protein_name": "Amelogenin, X isoform", "gene_name": "AMELX", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02671-1", "protein_name": "Fibrinogen alpha chain", "gene_name": "FGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12841-1", "protein_name": "Follistatin-related protein 1", "gene_name": "FSTL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95633-1", "protein_name": "Follistatin-related protein 3", "gene_name": "FSTL3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14791-1", "protein_name": "Apolipoprotein L1", "gene_name": "APOL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HCE9-1", "protein_name": "Anoctamin-8", "gene_name": "ANO8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04114-1", "protein_name": "Apolipoprotein B-100", "gene_name": "APOB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02751-15", "protein_name": "Fibronectin", "gene_name": "FN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01008-1", "protein_name": "Antithrombin-III", "gene_name": "SERPINC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UX39-1", "protein_name": "Amelotin", "gene_name": "AMTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01210-1", "protein_name": "Proenkephalin-A", "gene_name": "PENK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q02818-1", "protein_name": "Nucleobindin-1", "gene_name": "NUCB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07065-1", "protein_name": "Cytoskeleton-associated protein 4", "gene_name": "CKAP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02765-1", "protein_name": "Alpha-2-HS-glycoprotein", "gene_name": "AHSG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02679-1", "protein_name": "Fibrinogen gamma chain", "gene_name": "FGG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07237-1", "protein_name": "Protein disulfide-isomerase", "gene_name": "P4HB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14393-2", "protein_name": "Growth arrest-specific protein 6", "gene_name": "GAS6", 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"tax_name": "Human" }, { "uniprot_canonical_ac": "P23327-1", "protein_name": "Sarcoplasmic reticulum histidine-rich calcium-binding protein", "gene_name": "HRC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WXD2-1", "protein_name": "Secretogranin-3", "gene_name": "SCG3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01033-1", "protein_name": "Metalloproteinase inhibitor 1", "gene_name": "TIMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P17936-1", "protein_name": "Insulin-like growth factor-binding protein 3", "gene_name": "IGFBP3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02649-1", "protein_name": "Apolipoprotein E", "gene_name": "APOE", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13521-1", "protein_name": "Secretogranin-2", "gene_name": "SCG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08311-1", "protein_name": "Cathepsin G", "gene_name": "CTSG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00450-1", "protein_name": "Ceruloplasmin", "gene_name": "CP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P10451-1", "protein_name": "Osteopontin", "gene_name": "SPP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0C0L4-1", "protein_name": "Complement C4-A", "gene_name": "C4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00622-1", "protein_name": "CCN family member 1", "gene_name": "CCN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20151-1", "protein_name": "Kallikrein-2", "gene_name": "KLK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07942-1", "protein_name": "Laminin subunit beta-1", "gene_name": "LAMB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06870-1", "protein_name": "Kallikrein-1", "gene_name": "KLK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UKR3-1", "protein_name": "Kallikrein-13", "gene_name": "KLK13", "tax_name": "Human" }, { "uniprot_canonical_ac": "P11047-1", "protein_name": "Laminin subunit gamma-1", "gene_name": "LAMC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43493-2", "protein_name": "Trans-Golgi network integral membrane protein 2", "gene_name": "TGOLN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19823-1", "protein_name": "Inter-alpha-trypsin inhibitor heavy chain H2", "gene_name": "ITIH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13103-1", "protein_name": "Secreted phosphoprotein 24", "gene_name": "SPP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15240-1", "protein_name": "Neurosecretory protein VGF", "gene_name": "VGF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BU40-6", "protein_name": "Chordin-like protein 1", "gene_name": "CHRDL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24593-1", "protein_name": "Insulin-like growth factor-binding protein 5", "gene_name": "IGFBP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14703-1", "protein_name": "Membrane-bound transcription factor site-1 protease", "gene_name": "MBTPS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BXP8-1", "protein_name": "Pappalysin-2", "gene_name": "PAPPA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02652-1", "protein_name": "Apolipoprotein A-II", "gene_name": "APOA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NBP7-1", "protein_name": "Proprotein convertase subtilisin/kexin type 9", "gene_name": "PCSK9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IXL6-1", "protein_name": "Extracellular serine/threonine protein kinase FAM20C", "gene_name": "FAM20C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35858-1", "protein_name": "Insulin-like growth factor-binding protein complex acid labile subunit", "gene_name": "IGFALS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6Q788-1", "protein_name": "Apolipoprotein A-V", "gene_name": "APOA5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00747-1", "protein_name": "Plasminogen", "gene_name": "PLG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02768-1", "protein_name": "Albumin", "gene_name": "ALB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07288-1", "protein_name": "Prostate-specific antigen", "gene_name": "KLK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NP70-1", "protein_name": "Ameloblastin", "gene_name": "AMBN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5JRA6-1", "protein_name": "Transport and Golgi organization protein 1 homolog", "gene_name": "MIA3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04070-1", "protein_name": "Vitamin K-dependent protein C", "gene_name": "PROC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P34741-1", "protein_name": "Syndecan-2", "gene_name": "SDC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01034-1", "protein_name": "Cystatin-C", "gene_name": "CST3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H8M9-1", "protein_name": "Protein eva-1 homolog A", "gene_name": "EVA1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12259-1", "protein_name": "Coagulation factor V", "gene_name": "F5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NRM1-1", "protein_name": "Enamelin", "gene_name": "ENAM", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BTY2-1", "protein_name": "Plasma alpha-L-fucosidase", "gene_name": "FUCA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02787-1", "protein_name": "Serotransferrin", "gene_name": "TF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UK55-1", "protein_name": "Protein Z-dependent protease inhibitor", "gene_name": "SERPINA10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13611-1", "protein_name": "Versican core protein", "gene_name": "VCAN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86UP2-1", "protein_name": "Kinectin", "gene_name": "KTN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01042-1", "protein_name": "Kininogen-1", "gene_name": "KNG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12644-1", "protein_name": "Bone morphogenetic protein 4", "gene_name": "BMP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95972-1", "protein_name": "Bone morphogenetic protein 15", "gene_name": "BMP15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N4F0-1", "protein_name": "BPI fold-containing family B member 2", "gene_name": "BPIFB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19022-1", "protein_name": "Cadherin-2", "gene_name": "CDH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43852-1", "protein_name": "Calumenin", "gene_name": "CALU", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14515-1", "protein_name": "SPARC-like protein 1", "gene_name": "SPARCL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08253-1", "protein_name": "72 kDa type IV collagenase", "gene_name": "MMP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BRK3-1", "protein_name": "Matrix remodeling-associated protein 8", "gene_name": "MXRA8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16270-1", "protein_name": "Insulin-like growth factor-binding protein 7", "gene_name": "IGFBP7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96AD5-1", "protein_name": "Patatin-like phospholipase domain-containing protein 2", "gene_name": "PNPLA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05546-1", "protein_name": "Heparin cofactor 2", "gene_name": "SERPIND1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95084-1", "protein_name": "Serine protease 23", "gene_name": "PRSS23", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00391-1", "protein_name": "Sulfhydryl oxidase 1", "gene_name": "QSOX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15084-1", "protein_name": "Protein disulfide-isomerase A6", "gene_name": "PDIA6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15232-1", "protein_name": "Matrilin-3", "gene_name": "MATN3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76061-1", "protein_name": "Stanniocalcin-2", "gene_name": "STC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08582-1", "protein_name": "Melanotransferrin", "gene_name": "MELTF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N114-1", "protein_name": "Protein shisa-5", "gene_name": "SHISA5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09382-1", "protein_name": "Galectin-1", "gene_name": "LGALS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15293-1", "protein_name": "Reticulocalbin-1", "gene_name": "RCN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01024-1", "protein_name": "Complement C3", "gene_name": "C3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00255-2", "protein_name": "Menin", "gene_name": "MEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13316-1", "protein_name": "Dentin matrix acidic phosphoprotein 1", "gene_name": "DMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13217-1", "protein_name": "DnaJ homolog subfamily C member 3", "gene_name": "DNAJC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35555-1", "protein_name": "Fibrillin-1", "gene_name": "FBN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05060-1", "protein_name": "Secretogranin-1", "gene_name": "CHGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08833-1", "protein_name": "Insulin-like growth factor-binding protein 1", "gene_name": "IGFBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14314-1", "protein_name": "Glucosidase 2 subunit beta", "gene_name": "PRKCSH", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20718-1", "protein_name": "Granzyme H", "gene_name": "GZMH", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9GZV9-1", "protein_name": "Fibroblast growth factor 23", "gene_name": "FGF23", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18065-1", "protein_name": "Insulin-like growth factor-binding protein 2", "gene_name": "IGFBP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01344-1", "protein_name": "Insulin-like growth factor 2", "gene_name": "IGF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MK3-1", "protein_name": "Pseudokinase FAM20A", "gene_name": "FAM20A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05019-1", "protein_name": "Insulin-like growth factor 1", "gene_name": "IGF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24592-1", "protein_name": "Insulin-like growth factor-binding protein 6", "gene_name": "IGFBP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22692-1", "protein_name": "Insulin-like growth factor-binding protein 4", "gene_name": "IGFBP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08431-1", "protein_name": "Lactadherin", "gene_name": "MFGE8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55268-1", "protein_name": "Laminin subunit beta-2", "gene_name": "LAMB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ76-1", "protein_name": "Matrix extracellular phosphoglycoprotein", "gene_name": "MEPE", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM21-1", "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A", "gene_name": "MGAT4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24821-1", "protein_name": "Tenascin", "gene_name": "TNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76024-1", "protein_name": "Wolframin", "gene_name": "WFS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02771-1", "protein_name": "Alpha-fetoprotein", "gene_name": "AFP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14625-1", "protein_name": "Endoplasmin", "gene_name": "HSP90B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB0-1", "protein_name": "von Willebrand factor A domain-containing protein 1", "gene_name": "VWA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05067-1", "protein_name": "Amyloid-beta precursor protein", "gene_name": "APP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06481-1", "protein_name": "Amyloid beta precursor like protein 2", "gene_name": "APLP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14672-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02647-1", "protein_name": "Apolipoprotein A-I", "gene_name": "APOA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01009-1", "protein_name": "Alpha-1-antitrypsin", "gene_name": "SERPINA1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q14766", "url": "https://www.uniprot.org/uniprotkb/Q14766" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10512690", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 124 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": 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"glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "A central domain binding site in insulin-like growth factor binding protein-5 for the acid-labile subunit.", "journal": "Endocrinology", "date": "2000", "authors": "Twigg SM, Kiefer MC, Zapf J, Baxter RC", "reference": { "type": "PubMed", "id": "10614670", "url": "https://pubmed.ncbi.nlm.nih.gov/10614670" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q14766-1", "protein_name": "Latent-transforming growth factor beta-binding protein 1", "gene_name": "LTBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q24JP5-1", "protein_name": "Transmembrane protein 132A", "gene_name": "TMEM132A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00734-1", "protein_name": "Prothrombin", "gene_name": "F2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99217-1", "protein_name": "Amelogenin, X isoform", "gene_name": "AMELX", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02671-1", "protein_name": "Fibrinogen alpha chain", "gene_name": "FGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12841-1", "protein_name": "Follistatin-related protein 1", "gene_name": "FSTL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95633-1", "protein_name": "Follistatin-related protein 3", "gene_name": "FSTL3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14791-1", "protein_name": "Apolipoprotein L1", "gene_name": "APOL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HCE9-1", "protein_name": "Anoctamin-8", "gene_name": "ANO8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04114-1", "protein_name": "Apolipoprotein B-100", "gene_name": "APOB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02751-15", "protein_name": "Fibronectin", "gene_name": "FN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01008-1", "protein_name": "Antithrombin-III", "gene_name": "SERPINC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UX39-1", "protein_name": "Amelotin", "gene_name": "AMTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01210-1", "protein_name": "Proenkephalin-A", "gene_name": "PENK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q02818-1", "protein_name": "Nucleobindin-1", "gene_name": "NUCB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07065-1", "protein_name": "Cytoskeleton-associated protein 4", "gene_name": "CKAP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02765-1", "protein_name": "Alpha-2-HS-glycoprotein", "gene_name": "AHSG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02679-1", "protein_name": "Fibrinogen gamma chain", "gene_name": "FGG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07237-1", "protein_name": "Protein disulfide-isomerase", "gene_name": "P4HB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14393-2", "protein_name": "Growth arrest-specific protein 6", "gene_name": "GAS6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P51654-1", "protein_name": "Glypican-3", "gene_name": "GPC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NBJ4-1", "protein_name": "Golgi membrane protein 1", "gene_name": "GOLM1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09603-1", "protein_name": "Macrophage colony-stimulating factor 1", "gene_name": "CSF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05231-1", "protein_name": "Interleukin-6", "gene_name": "IL6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6P988-1", "protein_name": "Palmitoleoyl-protein carboxylesterase NOTUM", "gene_name": "NOTUM", "tax_name": "Human" }, { "uniprot_canonical_ac": "P03956-1", "protein_name": "Interstitial collagenase", "gene_name": "MMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13421-3", "protein_name": "Mesothelin", "gene_name": "MSLN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13219-1", "protein_name": "Pappalysin-1", "gene_name": "PAPPA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P23327-1", "protein_name": "Sarcoplasmic reticulum histidine-rich calcium-binding protein", "gene_name": "HRC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WXD2-1", "protein_name": "Secretogranin-3", "gene_name": "SCG3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01033-1", "protein_name": "Metalloproteinase inhibitor 1", "gene_name": "TIMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P17936-1", "protein_name": "Insulin-like growth factor-binding protein 3", "gene_name": "IGFBP3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02649-1", "protein_name": "Apolipoprotein E", "gene_name": "APOE", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13521-1", "protein_name": "Secretogranin-2", "gene_name": "SCG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08311-1", "protein_name": "Cathepsin G", "gene_name": "CTSG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00450-1", "protein_name": "Ceruloplasmin", "gene_name": "CP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P10451-1", "protein_name": "Osteopontin", "gene_name": "SPP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0C0L4-1", "protein_name": "Complement C4-A", "gene_name": "C4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00622-1", "protein_name": "CCN family member 1", "gene_name": "CCN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20151-1", "protein_name": "Kallikrein-2", "gene_name": "KLK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07942-1", "protein_name": "Laminin subunit beta-1", "gene_name": "LAMB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06870-1", "protein_name": "Kallikrein-1", 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"protein_name": "Kinectin", "gene_name": "KTN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01042-1", "protein_name": "Kininogen-1", "gene_name": "KNG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12644-1", "protein_name": "Bone morphogenetic protein 4", "gene_name": "BMP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95972-1", "protein_name": "Bone morphogenetic protein 15", "gene_name": "BMP15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N4F0-1", "protein_name": "BPI fold-containing family B member 2", "gene_name": "BPIFB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19022-1", "protein_name": "Cadherin-2", "gene_name": "CDH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43852-1", "protein_name": "Calumenin", "gene_name": "CALU", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14515-1", "protein_name": "SPARC-like protein 1", "gene_name": "SPARCL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08253-1", "protein_name": "72 kDa 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"tax_name": "Human" }, { "uniprot_canonical_ac": "O15232-1", "protein_name": "Matrilin-3", "gene_name": "MATN3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76061-1", "protein_name": "Stanniocalcin-2", "gene_name": "STC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08582-1", "protein_name": "Melanotransferrin", "gene_name": "MELTF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N114-1", "protein_name": "Protein shisa-5", "gene_name": "SHISA5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09382-1", "protein_name": "Galectin-1", "gene_name": "LGALS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15293-1", "protein_name": "Reticulocalbin-1", "gene_name": "RCN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01024-1", "protein_name": "Complement C3", "gene_name": "C3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00255-2", "protein_name": "Menin", "gene_name": "MEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13316-1", "protein_name": 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} ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl", "filter_code", "uniprot_canonical_ac" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Insulin-like growth factor binding protein (IGFBP)-3-bound IGF-I and IGFBP-3-bound IGF-II in growth hormone deficiency.", "journal": "Hormone research", "date": "1999", "authors": "Belgorosky A, Rivarola MA", "reference": { "type": "PubMed", "id": "10681634", "url": "https://pubmed.ncbi.nlm.nih.gov/10681634" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q14766-1", "protein_name": "Latent-transforming growth factor beta-binding protein 1", "gene_name": "LTBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q24JP5-1", "protein_name": "Transmembrane protein 132A", "gene_name": "TMEM132A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00734-1", "protein_name": "Prothrombin", "gene_name": "F2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99217-1", "protein_name": "Amelogenin, X isoform", "gene_name": "AMELX", "tax_name": 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"FBN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05060-1", "protein_name": "Secretogranin-1", "gene_name": "CHGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08833-1", "protein_name": "Insulin-like growth factor-binding protein 1", "gene_name": "IGFBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14314-1", "protein_name": "Glucosidase 2 subunit beta", "gene_name": "PRKCSH", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20718-1", "protein_name": "Granzyme H", "gene_name": "GZMH", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9GZV9-1", "protein_name": "Fibroblast growth factor 23", "gene_name": "FGF23", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18065-1", "protein_name": "Insulin-like growth factor-binding protein 2", "gene_name": "IGFBP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01344-1", "protein_name": "Insulin-like growth factor 2", "gene_name": "IGF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MK3-1", "protein_name": "Pseudokinase FAM20A", "gene_name": "FAM20A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05019-1", "protein_name": "Insulin-like growth factor 1", "gene_name": "IGF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24592-1", "protein_name": "Insulin-like growth factor-binding protein 6", "gene_name": "IGFBP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22692-1", "protein_name": "Insulin-like growth factor-binding protein 4", "gene_name": "IGFBP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08431-1", "protein_name": "Lactadherin", "gene_name": "MFGE8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55268-1", "protein_name": "Laminin subunit beta-2", "gene_name": "LAMB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ76-1", "protein_name": "Matrix extracellular phosphoglycoprotein", "gene_name": "MEPE", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM21-1", "protein_name": "Alpha-1,3-mannosyl-glycoprotein 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"gene_name": "MMP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BRK3-1", "protein_name": "Matrix remodeling-associated protein 8", "gene_name": "MXRA8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16270-1", "protein_name": "Insulin-like growth factor-binding protein 7", "gene_name": "IGFBP7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96AD5-1", "protein_name": "Patatin-like phospholipase domain-containing protein 2", "gene_name": "PNPLA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05546-1", "protein_name": "Heparin cofactor 2", "gene_name": "SERPIND1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95084-1", "protein_name": "Serine protease 23", "gene_name": "PRSS23", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00391-1", "protein_name": "Sulfhydryl oxidase 1", "gene_name": "QSOX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15084-1", "protein_name": "Protein disulfide-isomerase A6", "gene_name": "PDIA6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15232-1", "protein_name": "Matrilin-3", "gene_name": "MATN3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76061-1", "protein_name": "Stanniocalcin-2", "gene_name": "STC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08582-1", "protein_name": "Melanotransferrin", "gene_name": "MELTF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N114-1", "protein_name": "Protein shisa-5", "gene_name": "SHISA5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09382-1", "protein_name": "Galectin-1", "gene_name": "LGALS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15293-1", "protein_name": "Reticulocalbin-1", "gene_name": "RCN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01024-1", "protein_name": "Complement C3", "gene_name": "C3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00255-2", "protein_name": "Menin", "gene_name": "MEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13316-1", "protein_name": "Dentin matrix acidic phosphoprotein 1", "gene_name": "DMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13217-1", "protein_name": "DnaJ homolog subfamily C member 3", "gene_name": "DNAJC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35555-1", "protein_name": "Fibrillin-1", "gene_name": "FBN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05060-1", "protein_name": "Secretogranin-1", "gene_name": "CHGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08833-1", "protein_name": "Insulin-like growth factor-binding protein 1", "gene_name": "IGFBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14314-1", "protein_name": "Glucosidase 2 subunit beta", "gene_name": "PRKCSH", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20718-1", "protein_name": "Granzyme H", "gene_name": "GZMH", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9GZV9-1", "protein_name": "Fibroblast growth factor 23", "gene_name": "FGF23", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18065-1", "protein_name": "Insulin-like growth factor-binding protein 2", "gene_name": "IGFBP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01344-1", "protein_name": "Insulin-like growth factor 2", "gene_name": "IGF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MK3-1", "protein_name": "Pseudokinase FAM20A", "gene_name": "FAM20A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05019-1", "protein_name": "Insulin-like growth factor 1", "gene_name": "IGF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24592-1", "protein_name": "Insulin-like growth factor-binding protein 6", "gene_name": "IGFBP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22692-1", "protein_name": "Insulin-like growth factor-binding protein 4", "gene_name": "IGFBP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08431-1", "protein_name": "Lactadherin", "gene_name": "MFGE8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55268-1", "protein_name": "Laminin subunit beta-2", "gene_name": "LAMB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ76-1", "protein_name": "Matrix extracellular phosphoglycoprotein", "gene_name": "MEPE", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM21-1", "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A", "gene_name": "MGAT4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24821-1", "protein_name": "Tenascin", "gene_name": "TNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76024-1", "protein_name": "Wolframin", "gene_name": "WFS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02771-1", "protein_name": "Alpha-fetoprotein", "gene_name": "AFP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14625-1", "protein_name": "Endoplasmin", "gene_name": "HSP90B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB0-1", "protein_name": "von Willebrand factor A domain-containing protein 1", "gene_name": "VWA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05067-1", "protein_name": "Amyloid-beta precursor protein", "gene_name": "APP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06481-1", "protein_name": "Amyloid beta precursor like protein 2", "gene_name": "APLP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14672-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02647-1", "protein_name": "Apolipoprotein A-I", "gene_name": "APOA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01009-1", "protein_name": "Alpha-1-antitrypsin", "gene_name": "SERPINA1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q14766", "url": "https://www.uniprot.org/uniprotkb/Q14766" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10810289", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 124 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": 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"protein_name": "Follistatin-related protein 3", "gene_name": "FSTL3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14791-1", "protein_name": "Apolipoprotein L1", "gene_name": "APOL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HCE9-1", "protein_name": "Anoctamin-8", "gene_name": "ANO8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04114-1", "protein_name": "Apolipoprotein B-100", "gene_name": "APOB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02751-15", "protein_name": "Fibronectin", "gene_name": "FN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01008-1", "protein_name": "Antithrombin-III", "gene_name": "SERPINC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UX39-1", "protein_name": "Amelotin", "gene_name": "AMTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01210-1", "protein_name": "Proenkephalin-A", "gene_name": "PENK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q02818-1", "protein_name": "Nucleobindin-1", "gene_name": 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"protein_name": "Secreted phosphoprotein 24", "gene_name": "SPP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15240-1", "protein_name": "Neurosecretory protein VGF", "gene_name": "VGF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BU40-6", "protein_name": "Chordin-like protein 1", "gene_name": "CHRDL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24593-1", "protein_name": "Insulin-like growth factor-binding protein 5", "gene_name": "IGFBP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14703-1", "protein_name": "Membrane-bound transcription factor site-1 protease", "gene_name": "MBTPS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BXP8-1", "protein_name": "Pappalysin-2", "gene_name": "PAPPA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02652-1", "protein_name": "Apolipoprotein A-II", "gene_name": "APOA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NBP7-1", "protein_name": "Proprotein convertase subtilisin/kexin type 9", "gene_name": 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"P14314-1", "protein_name": "Glucosidase 2 subunit beta", "gene_name": "PRKCSH", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20718-1", "protein_name": "Granzyme H", "gene_name": "GZMH", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9GZV9-1", "protein_name": "Fibroblast growth factor 23", "gene_name": "FGF23", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18065-1", "protein_name": "Insulin-like growth factor-binding protein 2", "gene_name": "IGFBP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01344-1", "protein_name": "Insulin-like growth factor 2", "gene_name": "IGF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MK3-1", "protein_name": "Pseudokinase FAM20A", "gene_name": "FAM20A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05019-1", "protein_name": "Insulin-like growth factor 1", "gene_name": "IGF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24592-1", "protein_name": "Insulin-like growth factor-binding protein 6", "gene_name": "IGFBP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22692-1", "protein_name": "Insulin-like growth factor-binding protein 4", "gene_name": "IGFBP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08431-1", "protein_name": "Lactadherin", "gene_name": "MFGE8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55268-1", "protein_name": "Laminin subunit beta-2", "gene_name": "LAMB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ76-1", "protein_name": "Matrix extracellular phosphoglycoprotein", "gene_name": "MEPE", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM21-1", "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A", "gene_name": "MGAT4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24821-1", "protein_name": "Tenascin", "gene_name": "TNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76024-1", "protein_name": "Wolframin", "gene_name": "WFS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02771-1", "protein_name": "Alpha-fetoprotein", "gene_name": "AFP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14625-1", "protein_name": "Endoplasmin", "gene_name": "HSP90B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB0-1", "protein_name": "von Willebrand factor A domain-containing protein 1", "gene_name": "VWA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05067-1", "protein_name": "Amyloid-beta precursor protein", "gene_name": "APP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06481-1", "protein_name": "Amyloid beta precursor like protein 2", "gene_name": "APLP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14672-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02647-1", "protein_name": "Apolipoprotein A-I", "gene_name": "APOA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01009-1", "protein_name": "Alpha-1-antitrypsin", "gene_name": "SERPINA1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q14766", "url": "https://www.uniprot.org/uniprotkb/Q14766" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10898936", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 124 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Effects of IGFBP-2 overexpression in vitro and in vivo.", "journal": "Pediatric nephrology (Berlin, Germany)", "date": "2000", "authors": "Wolf E, Lahm H, Wu M, Wanke R, Hoeflich A", "reference": { "type": "PubMed", "id": "10912521", "url": "https://pubmed.ncbi.nlm.nih.gov/10912521" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q14766-1", "protein_name": "Latent-transforming growth factor beta-binding protein 1", "gene_name": "LTBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q24JP5-1", "protein_name": "Transmembrane protein 132A", "gene_name": "TMEM132A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00734-1", "protein_name": "Prothrombin", "gene_name": "F2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99217-1", "protein_name": "Amelogenin, X isoform", "gene_name": "AMELX", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02671-1", 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"P07288-1", "protein_name": "Prostate-specific antigen", "gene_name": "KLK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NP70-1", "protein_name": "Ameloblastin", "gene_name": "AMBN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5JRA6-1", "protein_name": "Transport and Golgi organization protein 1 homolog", "gene_name": "MIA3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04070-1", "protein_name": "Vitamin K-dependent protein C", "gene_name": "PROC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P34741-1", "protein_name": "Syndecan-2", "gene_name": "SDC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01034-1", "protein_name": "Cystatin-C", "gene_name": "CST3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H8M9-1", "protein_name": "Protein eva-1 homolog A", "gene_name": "EVA1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12259-1", "protein_name": "Coagulation factor V", "gene_name": "F5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NRM1-1", "protein_name": "Enamelin", "gene_name": "ENAM", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BTY2-1", "protein_name": "Plasma alpha-L-fucosidase", "gene_name": "FUCA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02787-1", "protein_name": "Serotransferrin", "gene_name": "TF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UK55-1", "protein_name": "Protein Z-dependent protease inhibitor", "gene_name": "SERPINA10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13611-1", "protein_name": "Versican core protein", "gene_name": "VCAN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86UP2-1", "protein_name": "Kinectin", "gene_name": "KTN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01042-1", "protein_name": "Kininogen-1", "gene_name": "KNG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12644-1", "protein_name": "Bone morphogenetic protein 4", "gene_name": "BMP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95972-1", "protein_name": "Bone morphogenetic protein 15", "gene_name": "BMP15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N4F0-1", "protein_name": "BPI fold-containing family B member 2", "gene_name": "BPIFB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19022-1", "protein_name": "Cadherin-2", "gene_name": "CDH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43852-1", "protein_name": "Calumenin", "gene_name": "CALU", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14515-1", "protein_name": "SPARC-like protein 1", "gene_name": "SPARCL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08253-1", "protein_name": "72 kDa type IV collagenase", "gene_name": "MMP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BRK3-1", "protein_name": "Matrix remodeling-associated protein 8", "gene_name": "MXRA8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16270-1", "protein_name": "Insulin-like growth factor-binding protein 7", "gene_name": "IGFBP7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96AD5-1", "protein_name": "Patatin-like phospholipase domain-containing protein 2", "gene_name": "PNPLA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05546-1", "protein_name": "Heparin cofactor 2", "gene_name": "SERPIND1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95084-1", "protein_name": "Serine protease 23", "gene_name": "PRSS23", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00391-1", "protein_name": "Sulfhydryl oxidase 1", "gene_name": "QSOX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15084-1", "protein_name": "Protein disulfide-isomerase A6", "gene_name": "PDIA6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15232-1", "protein_name": "Matrilin-3", "gene_name": "MATN3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76061-1", "protein_name": "Stanniocalcin-2", "gene_name": "STC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08582-1", "protein_name": "Melanotransferrin", "gene_name": "MELTF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N114-1", "protein_name": "Protein shisa-5", "gene_name": "SHISA5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09382-1", "protein_name": "Galectin-1", "gene_name": "LGALS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15293-1", "protein_name": "Reticulocalbin-1", "gene_name": "RCN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01024-1", "protein_name": "Complement C3", "gene_name": "C3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00255-2", "protein_name": "Menin", "gene_name": "MEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13316-1", "protein_name": "Dentin matrix acidic phosphoprotein 1", "gene_name": "DMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13217-1", "protein_name": "DnaJ homolog subfamily C member 3", "gene_name": "DNAJC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35555-1", "protein_name": "Fibrillin-1", "gene_name": "FBN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05060-1", "protein_name": "Secretogranin-1", "gene_name": "CHGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08833-1", "protein_name": "Insulin-like growth factor-binding protein 1", "gene_name": "IGFBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14314-1", "protein_name": "Glucosidase 2 subunit beta", "gene_name": "PRKCSH", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20718-1", "protein_name": "Granzyme H", "gene_name": "GZMH", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9GZV9-1", "protein_name": "Fibroblast growth factor 23", "gene_name": "FGF23", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18065-1", "protein_name": "Insulin-like growth factor-binding protein 2", "gene_name": "IGFBP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01344-1", "protein_name": "Insulin-like growth factor 2", "gene_name": "IGF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MK3-1", "protein_name": "Pseudokinase FAM20A", "gene_name": "FAM20A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05019-1", "protein_name": "Insulin-like growth factor 1", "gene_name": "IGF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24592-1", "protein_name": "Insulin-like growth factor-binding protein 6", "gene_name": "IGFBP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22692-1", "protein_name": "Insulin-like growth factor-binding protein 4", "gene_name": "IGFBP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08431-1", "protein_name": "Lactadherin", "gene_name": "MFGE8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55268-1", "protein_name": "Laminin subunit beta-2", "gene_name": "LAMB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ76-1", "protein_name": "Matrix extracellular phosphoglycoprotein", "gene_name": "MEPE", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM21-1", "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A", "gene_name": "MGAT4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24821-1", "protein_name": "Tenascin", "gene_name": "TNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76024-1", "protein_name": "Wolframin", "gene_name": "WFS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02771-1", "protein_name": "Alpha-fetoprotein", "gene_name": "AFP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14625-1", "protein_name": "Endoplasmin", "gene_name": "HSP90B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB0-1", "protein_name": "von Willebrand factor A domain-containing protein 1", "gene_name": "VWA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05067-1", "protein_name": "Amyloid-beta precursor protein", "gene_name": "APP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06481-1", "protein_name": "Amyloid beta precursor like protein 2", "gene_name": "APLP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14672-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02647-1", "protein_name": "Apolipoprotein A-I", "gene_name": "APOA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01009-1", "protein_name": "Alpha-1-antitrypsin", "gene_name": "SERPINA1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q14766", "url": "https://www.uniprot.org/uniprotkb/Q14766" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10912521", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 124 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "O-glycosylation of insulin-like growth factor (IGF) binding protein-6 maintains high IGF-II binding affinity by decreasing binding to glycosaminoglycans and susceptibility to proteolysis.", "journal": "European journal of biochemistry", "date": "2000", "authors": "Marinaro JA, Neumann GM, Russo VC, Leeding KS, Bach LA", "reference": { "type": "PubMed", "id": "10951195", "url": "https://pubmed.ncbi.nlm.nih.gov/10951195" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q14766-1", "protein_name": "Latent-transforming growth factor beta-binding protein 1", "gene_name": "LTBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q24JP5-1", "protein_name": "Transmembrane protein 132A", "gene_name": "TMEM132A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00734-1", "protein_name": "Prothrombin", "gene_name": "F2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99217-1", "protein_name": "Amelogenin, X isoform", "gene_name": "AMELX", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02671-1", "protein_name": "Fibrinogen alpha chain", "gene_name": "FGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12841-1", "protein_name": "Follistatin-related protein 1", "gene_name": "FSTL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95633-1", "protein_name": "Follistatin-related protein 3", "gene_name": "FSTL3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14791-1", "protein_name": "Apolipoprotein L1", "gene_name": "APOL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HCE9-1", "protein_name": "Anoctamin-8", "gene_name": "ANO8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04114-1", "protein_name": "Apolipoprotein B-100", "gene_name": "APOB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02751-15", "protein_name": "Fibronectin", "gene_name": "FN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01008-1", "protein_name": "Antithrombin-III", "gene_name": "SERPINC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UX39-1", "protein_name": "Amelotin", "gene_name": "AMTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01210-1", "protein_name": "Proenkephalin-A", "gene_name": "PENK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q02818-1", "protein_name": "Nucleobindin-1", "gene_name": "NUCB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07065-1", "protein_name": "Cytoskeleton-associated protein 4", "gene_name": "CKAP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02765-1", "protein_name": "Alpha-2-HS-glycoprotein", "gene_name": "AHSG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02679-1", "protein_name": "Fibrinogen gamma chain", "gene_name": "FGG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07237-1", "protein_name": "Protein disulfide-isomerase", "gene_name": "P4HB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14393-2", "protein_name": "Growth arrest-specific protein 6", "gene_name": "GAS6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P51654-1", "protein_name": "Glypican-3", "gene_name": "GPC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NBJ4-1", "protein_name": "Golgi membrane protein 1", "gene_name": "GOLM1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09603-1", "protein_name": "Macrophage colony-stimulating factor 1", "gene_name": "CSF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05231-1", "protein_name": "Interleukin-6", "gene_name": "IL6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6P988-1", "protein_name": "Palmitoleoyl-protein carboxylesterase NOTUM", "gene_name": "NOTUM", "tax_name": "Human" }, { "uniprot_canonical_ac": "P03956-1", "protein_name": "Interstitial collagenase", "gene_name": "MMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13421-3", "protein_name": "Mesothelin", "gene_name": "MSLN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13219-1", "protein_name": "Pappalysin-1", "gene_name": "PAPPA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P23327-1", "protein_name": "Sarcoplasmic reticulum histidine-rich calcium-binding protein", "gene_name": "HRC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WXD2-1", "protein_name": "Secretogranin-3", "gene_name": "SCG3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01033-1", "protein_name": "Metalloproteinase inhibitor 1", "gene_name": "TIMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P17936-1", "protein_name": "Insulin-like growth factor-binding protein 3", "gene_name": "IGFBP3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02649-1", "protein_name": "Apolipoprotein E", "gene_name": 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"protein_name": "Kallikrein-1", "gene_name": "KLK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UKR3-1", "protein_name": "Kallikrein-13", "gene_name": "KLK13", "tax_name": "Human" }, { "uniprot_canonical_ac": "P11047-1", "protein_name": "Laminin subunit gamma-1", "gene_name": "LAMC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43493-2", "protein_name": "Trans-Golgi network integral membrane protein 2", "gene_name": "TGOLN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19823-1", "protein_name": "Inter-alpha-trypsin inhibitor heavy chain H2", "gene_name": "ITIH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13103-1", "protein_name": "Secreted phosphoprotein 24", "gene_name": "SPP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15240-1", "protein_name": "Neurosecretory protein VGF", "gene_name": "VGF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BU40-6", "protein_name": "Chordin-like protein 1", "gene_name": "CHRDL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24593-1", "protein_name": "Insulin-like growth factor-binding protein 5", "gene_name": "IGFBP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14703-1", "protein_name": "Membrane-bound transcription factor site-1 protease", "gene_name": "MBTPS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BXP8-1", "protein_name": "Pappalysin-2", "gene_name": "PAPPA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02652-1", "protein_name": "Apolipoprotein A-II", "gene_name": "APOA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NBP7-1", "protein_name": "Proprotein convertase subtilisin/kexin type 9", "gene_name": "PCSK9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IXL6-1", "protein_name": "Extracellular serine/threonine protein kinase FAM20C", "gene_name": "FAM20C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35858-1", "protein_name": "Insulin-like growth factor-binding protein complex acid labile subunit", "gene_name": "IGFALS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6Q788-1", "protein_name": "Apolipoprotein A-V", "gene_name": "APOA5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00747-1", "protein_name": "Plasminogen", "gene_name": "PLG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02768-1", "protein_name": "Albumin", "gene_name": "ALB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07288-1", "protein_name": "Prostate-specific antigen", "gene_name": "KLK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NP70-1", "protein_name": "Ameloblastin", "gene_name": "AMBN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5JRA6-1", "protein_name": "Transport and Golgi organization protein 1 homolog", "gene_name": "MIA3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04070-1", "protein_name": "Vitamin K-dependent protein C", "gene_name": "PROC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P34741-1", "protein_name": "Syndecan-2", "gene_name": "SDC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01034-1", "protein_name": "Cystatin-C", "gene_name": "CST3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H8M9-1", "protein_name": "Protein eva-1 homolog A", "gene_name": "EVA1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12259-1", "protein_name": "Coagulation factor V", "gene_name": "F5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NRM1-1", "protein_name": "Enamelin", "gene_name": "ENAM", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BTY2-1", "protein_name": "Plasma alpha-L-fucosidase", "gene_name": "FUCA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02787-1", "protein_name": "Serotransferrin", "gene_name": "TF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UK55-1", "protein_name": "Protein Z-dependent protease inhibitor", "gene_name": "SERPINA10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13611-1", "protein_name": "Versican core protein", "gene_name": "VCAN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86UP2-1", "protein_name": "Kinectin", "gene_name": "KTN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01042-1", "protein_name": "Kininogen-1", "gene_name": "KNG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12644-1", "protein_name": "Bone morphogenetic protein 4", "gene_name": "BMP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95972-1", "protein_name": "Bone morphogenetic protein 15", "gene_name": "BMP15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N4F0-1", "protein_name": "BPI fold-containing family B member 2", "gene_name": "BPIFB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19022-1", "protein_name": "Cadherin-2", "gene_name": "CDH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43852-1", "protein_name": "Calumenin", "gene_name": "CALU", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14515-1", "protein_name": "SPARC-like protein 1", "gene_name": "SPARCL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08253-1", "protein_name": "72 kDa type IV collagenase", "gene_name": "MMP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BRK3-1", "protein_name": "Matrix remodeling-associated protein 8", "gene_name": "MXRA8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16270-1", "protein_name": "Insulin-like growth factor-binding protein 7", "gene_name": "IGFBP7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96AD5-1", "protein_name": "Patatin-like phospholipase domain-containing protein 2", "gene_name": "PNPLA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05546-1", "protein_name": "Heparin cofactor 2", "gene_name": "SERPIND1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95084-1", "protein_name": "Serine protease 23", "gene_name": "PRSS23", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00391-1", "protein_name": "Sulfhydryl oxidase 1", "gene_name": "QSOX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15084-1", "protein_name": "Protein disulfide-isomerase A6", "gene_name": "PDIA6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15232-1", "protein_name": "Matrilin-3", "gene_name": "MATN3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76061-1", "protein_name": "Stanniocalcin-2", "gene_name": "STC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08582-1", "protein_name": "Melanotransferrin", "gene_name": "MELTF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N114-1", "protein_name": "Protein shisa-5", "gene_name": "SHISA5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09382-1", "protein_name": "Galectin-1", "gene_name": "LGALS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15293-1", "protein_name": "Reticulocalbin-1", "gene_name": "RCN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01024-1", "protein_name": "Complement C3", "gene_name": "C3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00255-2", "protein_name": "Menin", "gene_name": "MEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13316-1", "protein_name": "Dentin matrix acidic phosphoprotein 1", "gene_name": "DMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13217-1", "protein_name": "DnaJ homolog subfamily C member 3", "gene_name": "DNAJC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35555-1", "protein_name": "Fibrillin-1", "gene_name": "FBN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05060-1", "protein_name": "Secretogranin-1", "gene_name": "CHGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08833-1", "protein_name": "Insulin-like growth factor-binding protein 1", "gene_name": "IGFBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14314-1", "protein_name": "Glucosidase 2 subunit beta", "gene_name": "PRKCSH", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20718-1", "protein_name": "Granzyme H", "gene_name": "GZMH", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9GZV9-1", "protein_name": "Fibroblast growth factor 23", "gene_name": "FGF23", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18065-1", "protein_name": "Insulin-like growth factor-binding protein 2", "gene_name": "IGFBP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01344-1", "protein_name": "Insulin-like growth factor 2", "gene_name": "IGF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MK3-1", "protein_name": "Pseudokinase FAM20A", "gene_name": "FAM20A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05019-1", "protein_name": "Insulin-like growth factor 1", "gene_name": "IGF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24592-1", "protein_name": "Insulin-like growth factor-binding protein 6", "gene_name": "IGFBP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22692-1", "protein_name": "Insulin-like growth factor-binding protein 4", "gene_name": "IGFBP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08431-1", "protein_name": "Lactadherin", "gene_name": "MFGE8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55268-1", "protein_name": "Laminin subunit beta-2", "gene_name": "LAMB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ76-1", "protein_name": "Matrix extracellular phosphoglycoprotein", "gene_name": "MEPE", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM21-1", "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A", "gene_name": "MGAT4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24821-1", "protein_name": "Tenascin", "gene_name": "TNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76024-1", "protein_name": "Wolframin", "gene_name": "WFS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02771-1", "protein_name": "Alpha-fetoprotein", "gene_name": "AFP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14625-1", "protein_name": "Endoplasmin", "gene_name": "HSP90B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB0-1", "protein_name": "von Willebrand factor A domain-containing protein 1", "gene_name": "VWA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05067-1", "protein_name": "Amyloid-beta precursor protein", "gene_name": "APP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06481-1", "protein_name": "Amyloid beta precursor like protein 2", "gene_name": "APLP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14672-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02647-1", "protein_name": "Apolipoprotein A-I", "gene_name": "APOA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01009-1", "protein_name": "Alpha-1-antitrypsin", "gene_name": "SERPINA1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q14766", "url": "https://www.uniprot.org/uniprotkb/Q14766" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10951195", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 124 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Prostate carcinoma (PC-3) cell proliferation is stimulated by the 22-25-kDa proteolytic fragment (1-160) and inhibited by the 16-kDa fragment (1-95) of recombinant human insulin-like growth factor binding protein-3.", "journal": "Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society", "date": "1998", "authors": "Angelloz-Nicoud P, Lalou C, Binoux M", "reference": { "type": "PubMed", "id": "10990447", "url": "https://pubmed.ncbi.nlm.nih.gov/10990447" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q14766-1", "protein_name": "Latent-transforming growth factor beta-binding protein 1", "gene_name": "LTBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q24JP5-1", "protein_name": "Transmembrane protein 132A", "gene_name": "TMEM132A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00734-1", "protein_name": "Prothrombin", "gene_name": "F2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99217-1", "protein_name": "Amelogenin, X isoform", "gene_name": "AMELX", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02671-1", "protein_name": "Fibrinogen alpha chain", "gene_name": "FGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12841-1", "protein_name": "Follistatin-related protein 1", "gene_name": "FSTL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95633-1", "protein_name": "Follistatin-related protein 3", "gene_name": "FSTL3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14791-1", "protein_name": "Apolipoprotein L1", "gene_name": "APOL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HCE9-1", "protein_name": "Anoctamin-8", "gene_name": "ANO8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04114-1", "protein_name": "Apolipoprotein B-100", "gene_name": "APOB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02751-15", "protein_name": "Fibronectin", "gene_name": "FN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01008-1", "protein_name": "Antithrombin-III", "gene_name": "SERPINC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UX39-1", "protein_name": "Amelotin", "gene_name": "AMTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01210-1", "protein_name": "Proenkephalin-A", "gene_name": "PENK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q02818-1", "protein_name": "Nucleobindin-1", "gene_name": "NUCB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07065-1", "protein_name": "Cytoskeleton-associated protein 4", "gene_name": "CKAP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02765-1", "protein_name": "Alpha-2-HS-glycoprotein", "gene_name": "AHSG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02679-1", "protein_name": "Fibrinogen gamma chain", "gene_name": "FGG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07237-1", "protein_name": "Protein disulfide-isomerase", "gene_name": "P4HB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14393-2", "protein_name": "Growth arrest-specific protein 6", "gene_name": "GAS6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P51654-1", "protein_name": "Glypican-3", "gene_name": "GPC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NBJ4-1", "protein_name": "Golgi membrane protein 1", "gene_name": "GOLM1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09603-1", "protein_name": "Macrophage colony-stimulating factor 1", "gene_name": "CSF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05231-1", "protein_name": "Interleukin-6", "gene_name": "IL6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6P988-1", "protein_name": "Palmitoleoyl-protein carboxylesterase NOTUM", "gene_name": "NOTUM", "tax_name": "Human" }, { "uniprot_canonical_ac": "P03956-1", "protein_name": "Interstitial collagenase", "gene_name": "MMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13421-3", "protein_name": "Mesothelin", "gene_name": "MSLN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13219-1", "protein_name": "Pappalysin-1", "gene_name": "PAPPA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P23327-1", "protein_name": "Sarcoplasmic reticulum histidine-rich calcium-binding protein", "gene_name": "HRC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WXD2-1", "protein_name": "Secretogranin-3", "gene_name": "SCG3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01033-1", "protein_name": "Metalloproteinase inhibitor 1", "gene_name": "TIMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P17936-1", "protein_name": "Insulin-like growth factor-binding protein 3", "gene_name": "IGFBP3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02649-1", "protein_name": "Apolipoprotein E", "gene_name": "APOE", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13521-1", "protein_name": "Secretogranin-2", "gene_name": "SCG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08311-1", "protein_name": "Cathepsin G", "gene_name": "CTSG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00450-1", "protein_name": "Ceruloplasmin", "gene_name": "CP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P10451-1", "protein_name": "Osteopontin", "gene_name": "SPP1", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"protein_name": "Inter-alpha-trypsin inhibitor heavy chain H2", "gene_name": "ITIH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13103-1", "protein_name": "Secreted phosphoprotein 24", "gene_name": "SPP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15240-1", "protein_name": "Neurosecretory protein VGF", "gene_name": "VGF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BU40-6", "protein_name": "Chordin-like protein 1", "gene_name": "CHRDL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24593-1", "protein_name": "Insulin-like growth factor-binding protein 5", "gene_name": "IGFBP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14703-1", "protein_name": "Membrane-bound transcription factor site-1 protease", "gene_name": "MBTPS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BXP8-1", "protein_name": "Pappalysin-2", "gene_name": "PAPPA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02652-1", "protein_name": "Apolipoprotein A-II", "gene_name": 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"uniprot_canonical_ac": "Q9NP70-1", "protein_name": "Ameloblastin", "gene_name": "AMBN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5JRA6-1", "protein_name": "Transport and Golgi organization protein 1 homolog", "gene_name": "MIA3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04070-1", "protein_name": "Vitamin K-dependent protein C", "gene_name": "PROC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P34741-1", "protein_name": "Syndecan-2", "gene_name": "SDC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01034-1", "protein_name": "Cystatin-C", "gene_name": "CST3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H8M9-1", "protein_name": "Protein eva-1 homolog A", "gene_name": "EVA1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12259-1", "protein_name": "Coagulation factor V", "gene_name": "F5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NRM1-1", "protein_name": "Enamelin", "gene_name": "ENAM", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"Q8N4F0-1", "protein_name": "BPI fold-containing family B member 2", "gene_name": "BPIFB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19022-1", "protein_name": "Cadherin-2", "gene_name": "CDH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43852-1", "protein_name": "Calumenin", "gene_name": "CALU", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14515-1", "protein_name": "SPARC-like protein 1", "gene_name": "SPARCL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08253-1", "protein_name": "72 kDa type IV collagenase", "gene_name": "MMP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BRK3-1", "protein_name": "Matrix remodeling-associated protein 8", "gene_name": "MXRA8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16270-1", "protein_name": "Insulin-like growth factor-binding protein 7", "gene_name": "IGFBP7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96AD5-1", "protein_name": "Patatin-like phospholipase domain-containing protein 2", "gene_name": "PNPLA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05546-1", "protein_name": "Heparin cofactor 2", "gene_name": "SERPIND1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95084-1", "protein_name": "Serine protease 23", "gene_name": "PRSS23", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00391-1", "protein_name": "Sulfhydryl oxidase 1", "gene_name": "QSOX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15084-1", "protein_name": "Protein disulfide-isomerase A6", "gene_name": "PDIA6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15232-1", "protein_name": "Matrilin-3", "gene_name": "MATN3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76061-1", "protein_name": "Stanniocalcin-2", "gene_name": "STC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08582-1", "protein_name": "Melanotransferrin", "gene_name": "MELTF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N114-1", "protein_name": "Protein shisa-5", "gene_name": "SHISA5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09382-1", "protein_name": "Galectin-1", "gene_name": "LGALS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15293-1", "protein_name": "Reticulocalbin-1", "gene_name": "RCN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01024-1", "protein_name": "Complement C3", "gene_name": "C3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00255-2", "protein_name": "Menin", "gene_name": "MEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13316-1", "protein_name": "Dentin matrix acidic phosphoprotein 1", "gene_name": "DMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13217-1", "protein_name": "DnaJ homolog subfamily C member 3", "gene_name": "DNAJC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35555-1", "protein_name": "Fibrillin-1", "gene_name": "FBN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05060-1", "protein_name": "Secretogranin-1", "gene_name": "CHGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08833-1", "protein_name": "Insulin-like growth factor-binding protein 1", "gene_name": "IGFBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14314-1", "protein_name": "Glucosidase 2 subunit beta", "gene_name": "PRKCSH", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20718-1", "protein_name": "Granzyme H", "gene_name": "GZMH", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9GZV9-1", "protein_name": "Fibroblast growth factor 23", "gene_name": "FGF23", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18065-1", "protein_name": "Insulin-like growth factor-binding protein 2", "gene_name": "IGFBP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01344-1", "protein_name": "Insulin-like growth factor 2", "gene_name": "IGF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MK3-1", "protein_name": "Pseudokinase FAM20A", "gene_name": "FAM20A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05019-1", "protein_name": "Insulin-like growth factor 1", "gene_name": "IGF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24592-1", "protein_name": "Insulin-like growth factor-binding protein 6", "gene_name": "IGFBP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22692-1", "protein_name": "Insulin-like growth factor-binding protein 4", "gene_name": "IGFBP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08431-1", "protein_name": "Lactadherin", "gene_name": "MFGE8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55268-1", "protein_name": "Laminin subunit beta-2", "gene_name": "LAMB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ76-1", "protein_name": "Matrix extracellular phosphoglycoprotein", "gene_name": "MEPE", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM21-1", "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A", "gene_name": "MGAT4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24821-1", "protein_name": "Tenascin", "gene_name": "TNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76024-1", "protein_name": "Wolframin", "gene_name": "WFS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02771-1", "protein_name": "Alpha-fetoprotein", "gene_name": "AFP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14625-1", "protein_name": "Endoplasmin", "gene_name": "HSP90B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB0-1", "protein_name": "von Willebrand factor A domain-containing protein 1", "gene_name": "VWA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05067-1", "protein_name": "Amyloid-beta precursor protein", "gene_name": "APP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06481-1", "protein_name": "Amyloid beta precursor like protein 2", "gene_name": "APLP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14672-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02647-1", "protein_name": "Apolipoprotein A-I", "gene_name": "APOA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01009-1", "protein_name": "Alpha-1-antitrypsin", "gene_name": "SERPINA1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q14766", "url": "https://www.uniprot.org/uniprotkb/Q14766" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10990447", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 124 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": 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"protein_name": "Integrin beta-5", "gene_name": "ITGB5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13485-1", "protein_name": "SMAD family member 4", "gene_name": "SMAD4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15796-1", "protein_name": "SMAD family member 2", "gene_name": "SMAD2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14767-1", "protein_name": "Latent-transforming growth factor beta-binding protein 2", "gene_name": "LTBP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09958-1", "protein_name": "Furin", "gene_name": "FURIN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P10600-1", "protein_name": "Transforming growth factor beta-3 proprotein", "gene_name": "TGFB3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15843-1", "protein_name": "Ubiquitin-like protein NEDD8", "gene_name": "NEDD8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61081-1", "protein_name": "NEDD8-conjugating enzyme Ubc12", "gene_name": "UBE2M", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18564-1", "protein_name": "Integrin beta-6", "gene_name": "ITGB6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06756-1", "protein_name": "Integrin alpha-V", "gene_name": "ITGAV", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53708-1", "protein_name": "Integrin alpha-8", "gene_name": "ITGA8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36897-1", "protein_name": "TGF-beta receptor type-1", "gene_name": "TGFBR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62942-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP1A", "gene_name": "FKBP1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P84022-1", "protein_name": "SMAD family member 3", "gene_name": "SMAD3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05556-1", "protein_name": "Integrin beta-1", "gene_name": "ITGB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05106-1", "protein_name": "Integrin beta-3", "gene_name": "ITGB3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P37173-1", "protein_name": "TGF-beta receptor type-2", "gene_name": "TGFBR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P26012-1", "protein_name": "Integrin beta-8", "gene_name": "ITGB8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N2S1-1", "protein_name": "Latent-transforming growth factor beta-binding protein 4", "gene_name": "LTBP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35555-1", "protein_name": "Fibrillin-1", "gene_name": "FBN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q03167-1", "protein_name": "Transforming growth factor beta receptor type 3", "gene_name": "TGFBR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01137-1", "protein_name": "Transforming growth factor beta-1 proprotein", "gene_name": "TGFB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61812-1", "protein_name": "Transforming growth factor beta-2 proprotein", "gene_name": "TGFB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22681-1", "protein_name": "E3 ubiquitin-protein ligase CBL", "gene_name": "CBL", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q14766", "url": "https://www.uniprot.org/uniprotkb/Q14766" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11100470", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 26 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The latent transforming growth factor beta binding protein (LTBP) family.", "journal": "Biochem. J.", "date": "2000", "authors": "Oklu R, Hesketh R", "reference": { "type": "PubMed", "id": "11104663", "url": "https://pubmed.ncbi.nlm.nih.gov/11104663" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q14766-1", "protein_name": "Latent-transforming growth factor beta-binding protein 1", "gene_name": "LTBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NS15-1", "protein_name": "Latent-transforming growth factor beta-binding protein 3", "gene_name": "LTBP3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O35806-1", "protein_name": "Latent-transforming growth factor beta-binding protein 2", "gene_name": "Ltbp2", "tax_name": "Rat" }, { "uniprot_canonical_ac": "Q28019-1", "protein_name": "Latent-transforming growth factor beta-binding protein 2", "gene_name": "LTBP2", "tax_name": "Bovine" }, { "uniprot_canonical_ac": "Q14767-1", "protein_name": "Latent-transforming growth factor beta-binding protein 2", "gene_name": "LTBP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00918-1", "protein_name": "Latent-transforming growth factor beta-binding protein 1", "gene_name": "Ltbp1; Ttc27", "tax_name": "Rat" }, { "uniprot_canonical_ac": "Q61810-1", "protein_name": "Latent-transforming growth factor beta-binding protein 3", "gene_name": "Ltbp3", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "O08999-1", "protein_name": "Latent-transforming growth factor beta-binding protein 2", "gene_name": "Ltbp2", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q8CG19-1", "protein_name": "Latent-transforming growth factor beta-binding protein 1", "gene_name": "Ltbp1", "tax_name": "Mouse" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q14766", "url": "https://www.uniprot.org/uniprotkb/Q14766" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11104663", "abstract": "", "glycosylation": [], "mutagenesis": [], 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"gene_name": "TF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UK55-1", "protein_name": "Protein Z-dependent protease inhibitor", "gene_name": "SERPINA10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13611-1", "protein_name": "Versican core protein", "gene_name": "VCAN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86UP2-1", "protein_name": "Kinectin", "gene_name": "KTN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01042-1", "protein_name": "Kininogen-1", "gene_name": "KNG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12644-1", "protein_name": "Bone morphogenetic protein 4", "gene_name": "BMP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95972-1", "protein_name": "Bone morphogenetic protein 15", "gene_name": "BMP15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N4F0-1", "protein_name": "BPI fold-containing family B member 2", "gene_name": "BPIFB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19022-1", "protein_name": 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"uniprot_canonical_ac": "O95084-1", "protein_name": "Serine protease 23", "gene_name": "PRSS23", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00391-1", "protein_name": "Sulfhydryl oxidase 1", "gene_name": "QSOX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15084-1", "protein_name": "Protein disulfide-isomerase A6", "gene_name": "PDIA6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15232-1", "protein_name": "Matrilin-3", "gene_name": "MATN3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76061-1", "protein_name": "Stanniocalcin-2", "gene_name": "STC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08582-1", "protein_name": "Melanotransferrin", "gene_name": "MELTF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N114-1", "protein_name": "Protein shisa-5", "gene_name": "SHISA5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09382-1", "protein_name": "Galectin-1", "gene_name": "LGALS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15293-1", "protein_name": "Reticulocalbin-1", "gene_name": "RCN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01024-1", "protein_name": "Complement C3", "gene_name": "C3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00255-2", "protein_name": "Menin", "gene_name": "MEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13316-1", "protein_name": "Dentin matrix acidic phosphoprotein 1", "gene_name": "DMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13217-1", "protein_name": "DnaJ homolog subfamily C member 3", "gene_name": "DNAJC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35555-1", "protein_name": "Fibrillin-1", "gene_name": "FBN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05060-1", "protein_name": "Secretogranin-1", "gene_name": "CHGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08833-1", "protein_name": "Insulin-like growth factor-binding protein 1", "gene_name": "IGFBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14314-1", "protein_name": "Glucosidase 2 subunit beta", "gene_name": "PRKCSH", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20718-1", "protein_name": "Granzyme H", "gene_name": "GZMH", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9GZV9-1", "protein_name": "Fibroblast growth factor 23", "gene_name": "FGF23", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18065-1", "protein_name": "Insulin-like growth factor-binding protein 2", "gene_name": "IGFBP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01344-1", "protein_name": "Insulin-like growth factor 2", "gene_name": "IGF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MK3-1", "protein_name": "Pseudokinase FAM20A", "gene_name": "FAM20A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05019-1", "protein_name": "Insulin-like growth factor 1", "gene_name": "IGF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24592-1", "protein_name": "Insulin-like growth factor-binding protein 6", "gene_name": "IGFBP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22692-1", "protein_name": "Insulin-like growth factor-binding protein 4", "gene_name": "IGFBP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08431-1", "protein_name": "Lactadherin", "gene_name": "MFGE8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55268-1", "protein_name": "Laminin subunit beta-2", "gene_name": "LAMB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ76-1", "protein_name": "Matrix extracellular phosphoglycoprotein", "gene_name": "MEPE", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM21-1", "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A", "gene_name": "MGAT4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24821-1", "protein_name": "Tenascin", "gene_name": "TNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76024-1", "protein_name": "Wolframin", "gene_name": "WFS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02771-1", "protein_name": "Alpha-fetoprotein", "gene_name": "AFP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14625-1", "protein_name": "Endoplasmin", "gene_name": "HSP90B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB0-1", "protein_name": "von Willebrand factor A domain-containing protein 1", "gene_name": "VWA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05067-1", "protein_name": "Amyloid-beta precursor protein", "gene_name": "APP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06481-1", "protein_name": "Amyloid beta precursor like protein 2", "gene_name": "APLP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14672-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02647-1", "protein_name": "Apolipoprotein A-I", "gene_name": "APOA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01009-1", "protein_name": "Alpha-1-antitrypsin", "gene_name": "SERPINA1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q14766", "url": "https://www.uniprot.org/uniprotkb/Q14766" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11158056", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 124 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Ligand-binding characteristics of recombinant amino- and carboxyl-terminal fragments of human insulin-like growth factor-binding protein-3.", "journal": "The Journal of endocrinology", "date": "2001", "authors": "Galanis M, Firth SM, Bond J, Nathanielsz A, Kortt AA, Hudson PJ, Baxter RC", "reference": { "type": "PubMed", "id": "11250653", "url": "https://pubmed.ncbi.nlm.nih.gov/11250653" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q14766-1", "protein_name": "Latent-transforming growth factor beta-binding protein 1", "gene_name": "LTBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q24JP5-1", "protein_name": "Transmembrane protein 132A", "gene_name": "TMEM132A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00734-1", "protein_name": "Prothrombin", "gene_name": "F2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99217-1", "protein_name": 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"gene_name": "SERPINC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UX39-1", "protein_name": "Amelotin", "gene_name": "AMTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01210-1", "protein_name": "Proenkephalin-A", "gene_name": "PENK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q02818-1", "protein_name": "Nucleobindin-1", "gene_name": "NUCB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07065-1", "protein_name": "Cytoskeleton-associated protein 4", "gene_name": "CKAP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02765-1", "protein_name": "Alpha-2-HS-glycoprotein", "gene_name": "AHSG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02679-1", "protein_name": "Fibrinogen gamma chain", "gene_name": "FGG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07237-1", "protein_name": "Protein disulfide-isomerase", "gene_name": "P4HB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14393-2", "protein_name": "Growth arrest-specific protein 6", 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"protein_name": "Albumin", "gene_name": "ALB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07288-1", "protein_name": "Prostate-specific antigen", "gene_name": "KLK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NP70-1", "protein_name": "Ameloblastin", "gene_name": "AMBN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5JRA6-1", "protein_name": "Transport and Golgi organization protein 1 homolog", "gene_name": "MIA3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04070-1", "protein_name": "Vitamin K-dependent protein C", "gene_name": "PROC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P34741-1", "protein_name": "Syndecan-2", "gene_name": "SDC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01034-1", "protein_name": "Cystatin-C", "gene_name": "CST3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H8M9-1", "protein_name": "Protein eva-1 homolog A", "gene_name": "EVA1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12259-1", "protein_name": "Coagulation factor V", "gene_name": "F5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NRM1-1", "protein_name": "Enamelin", "gene_name": "ENAM", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BTY2-1", "protein_name": "Plasma alpha-L-fucosidase", "gene_name": "FUCA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02787-1", "protein_name": "Serotransferrin", "gene_name": "TF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UK55-1", "protein_name": "Protein Z-dependent protease inhibitor", "gene_name": "SERPINA10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13611-1", "protein_name": "Versican core protein", "gene_name": "VCAN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86UP2-1", "protein_name": "Kinectin", "gene_name": "KTN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01042-1", "protein_name": "Kininogen-1", "gene_name": "KNG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12644-1", "protein_name": "Bone morphogenetic protein 4", "gene_name": "BMP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95972-1", "protein_name": "Bone morphogenetic protein 15", "gene_name": "BMP15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N4F0-1", "protein_name": "BPI fold-containing family B member 2", "gene_name": "BPIFB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19022-1", "protein_name": "Cadherin-2", "gene_name": "CDH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43852-1", "protein_name": "Calumenin", "gene_name": "CALU", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14515-1", "protein_name": "SPARC-like protein 1", "gene_name": "SPARCL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08253-1", "protein_name": "72 kDa type IV collagenase", "gene_name": "MMP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BRK3-1", "protein_name": "Matrix remodeling-associated protein 8", "gene_name": "MXRA8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16270-1", "protein_name": "Insulin-like growth factor-binding protein 7", "gene_name": "IGFBP7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96AD5-1", "protein_name": "Patatin-like phospholipase domain-containing protein 2", "gene_name": "PNPLA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05546-1", "protein_name": "Heparin cofactor 2", "gene_name": "SERPIND1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95084-1", "protein_name": "Serine protease 23", "gene_name": "PRSS23", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00391-1", "protein_name": "Sulfhydryl oxidase 1", "gene_name": "QSOX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15084-1", "protein_name": "Protein disulfide-isomerase A6", "gene_name": "PDIA6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15232-1", "protein_name": "Matrilin-3", "gene_name": "MATN3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76061-1", "protein_name": "Stanniocalcin-2", "gene_name": "STC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08582-1", "protein_name": "Melanotransferrin", "gene_name": "MELTF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N114-1", "protein_name": "Protein shisa-5", "gene_name": "SHISA5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09382-1", "protein_name": "Galectin-1", "gene_name": "LGALS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15293-1", "protein_name": "Reticulocalbin-1", "gene_name": "RCN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01024-1", "protein_name": "Complement C3", "gene_name": "C3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00255-2", "protein_name": "Menin", "gene_name": "MEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13316-1", "protein_name": "Dentin matrix acidic phosphoprotein 1", "gene_name": "DMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13217-1", "protein_name": "DnaJ homolog subfamily C member 3", "gene_name": "DNAJC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35555-1", "protein_name": "Fibrillin-1", "gene_name": "FBN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05060-1", "protein_name": "Secretogranin-1", "gene_name": "CHGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08833-1", "protein_name": "Insulin-like growth factor-binding protein 1", "gene_name": "IGFBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14314-1", "protein_name": "Glucosidase 2 subunit beta", "gene_name": "PRKCSH", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20718-1", "protein_name": "Granzyme H", "gene_name": "GZMH", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9GZV9-1", "protein_name": "Fibroblast growth factor 23", "gene_name": "FGF23", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18065-1", "protein_name": "Insulin-like growth factor-binding protein 2", "gene_name": "IGFBP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01344-1", "protein_name": "Insulin-like growth factor 2", "gene_name": "IGF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MK3-1", "protein_name": "Pseudokinase FAM20A", "gene_name": "FAM20A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05019-1", "protein_name": "Insulin-like growth factor 1", "gene_name": "IGF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24592-1", "protein_name": "Insulin-like growth factor-binding protein 6", "gene_name": "IGFBP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22692-1", "protein_name": "Insulin-like growth factor-binding protein 4", "gene_name": "IGFBP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08431-1", "protein_name": "Lactadherin", "gene_name": "MFGE8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55268-1", "protein_name": "Laminin subunit beta-2", "gene_name": "LAMB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ76-1", "protein_name": "Matrix extracellular phosphoglycoprotein", "gene_name": "MEPE", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM21-1", "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A", "gene_name": "MGAT4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24821-1", "protein_name": "Tenascin", "gene_name": "TNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76024-1", "protein_name": "Wolframin", "gene_name": "WFS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02771-1", "protein_name": "Alpha-fetoprotein", "gene_name": "AFP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14625-1", "protein_name": "Endoplasmin", "gene_name": "HSP90B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB0-1", "protein_name": "von Willebrand factor A domain-containing protein 1", "gene_name": "VWA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05067-1", "protein_name": "Amyloid-beta precursor protein", "gene_name": "APP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06481-1", "protein_name": "Amyloid beta precursor like protein 2", "gene_name": "APLP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14672-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02647-1", "protein_name": "Apolipoprotein A-I", "gene_name": "APOA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01009-1", "protein_name": "Alpha-1-antitrypsin", "gene_name": "SERPINA1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q14766", "url": "https://www.uniprot.org/uniprotkb/Q14766" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11250653", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 124 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Overgaard MT, Boldt HB, Laursen LS, Sottrup-Jensen L, Conover CA, Oxvig C", "reference": { "type": "PubMed", "id": "11264294", "url": "https://pubmed.ncbi.nlm.nih.gov/11264294" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q14766-1", "protein_name": "Latent-transforming growth factor beta-binding protein 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"gene_name": "ANO8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04114-1", "protein_name": "Apolipoprotein B-100", "gene_name": "APOB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02751-15", "protein_name": "Fibronectin", "gene_name": "FN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01008-1", "protein_name": "Antithrombin-III", "gene_name": "SERPINC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UX39-1", "protein_name": "Amelotin", "gene_name": "AMTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01210-1", "protein_name": "Proenkephalin-A", "gene_name": "PENK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q02818-1", "protein_name": "Nucleobindin-1", "gene_name": "NUCB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07065-1", "protein_name": "Cytoskeleton-associated protein 4", "gene_name": "CKAP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02765-1", "protein_name": "Alpha-2-HS-glycoprotein", "gene_name": "AHSG", "tax_name": 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"gene_name": "NOTUM", "tax_name": "Human" }, { "uniprot_canonical_ac": "P03956-1", "protein_name": "Interstitial collagenase", "gene_name": "MMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13421-3", "protein_name": "Mesothelin", "gene_name": "MSLN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13219-1", "protein_name": "Pappalysin-1", "gene_name": "PAPPA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P23327-1", "protein_name": "Sarcoplasmic reticulum histidine-rich calcium-binding protein", "gene_name": "HRC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WXD2-1", "protein_name": "Secretogranin-3", "gene_name": "SCG3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01033-1", "protein_name": "Metalloproteinase inhibitor 1", "gene_name": "TIMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P17936-1", "protein_name": "Insulin-like growth factor-binding protein 3", "gene_name": "IGFBP3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02649-1", "protein_name": "Apolipoprotein E", "gene_name": "APOE", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13521-1", "protein_name": "Secretogranin-2", "gene_name": "SCG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08311-1", "protein_name": "Cathepsin G", "gene_name": "CTSG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00450-1", "protein_name": "Ceruloplasmin", "gene_name": "CP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P10451-1", "protein_name": "Osteopontin", "gene_name": "SPP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0C0L4-1", "protein_name": "Complement C4-A", "gene_name": "C4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00622-1", "protein_name": "CCN family member 1", "gene_name": "CCN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20151-1", "protein_name": "Kallikrein-2", "gene_name": "KLK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07942-1", "protein_name": "Laminin subunit beta-1", "gene_name": "LAMB1", "tax_name": 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"gene_name": "CHRDL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24593-1", "protein_name": "Insulin-like growth factor-binding protein 5", "gene_name": "IGFBP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14703-1", "protein_name": "Membrane-bound transcription factor site-1 protease", "gene_name": "MBTPS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BXP8-1", "protein_name": "Pappalysin-2", "gene_name": "PAPPA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02652-1", "protein_name": "Apolipoprotein A-II", "gene_name": "APOA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NBP7-1", "protein_name": "Proprotein convertase subtilisin/kexin type 9", "gene_name": "PCSK9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IXL6-1", "protein_name": "Extracellular serine/threonine protein kinase FAM20C", "gene_name": "FAM20C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35858-1", "protein_name": "Insulin-like growth factor-binding protein complex 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"gene_name": "SDC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01034-1", "protein_name": "Cystatin-C", "gene_name": "CST3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H8M9-1", "protein_name": "Protein eva-1 homolog A", "gene_name": "EVA1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12259-1", "protein_name": "Coagulation factor V", "gene_name": "F5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NRM1-1", "protein_name": "Enamelin", "gene_name": "ENAM", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BTY2-1", "protein_name": "Plasma alpha-L-fucosidase", "gene_name": "FUCA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02787-1", "protein_name": "Serotransferrin", "gene_name": "TF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UK55-1", "protein_name": "Protein Z-dependent protease inhibitor", "gene_name": "SERPINA10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13611-1", "protein_name": "Versican core protein", "gene_name": "VCAN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86UP2-1", "protein_name": "Kinectin", "gene_name": "KTN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01042-1", "protein_name": "Kininogen-1", "gene_name": "KNG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12644-1", "protein_name": "Bone morphogenetic protein 4", "gene_name": "BMP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95972-1", "protein_name": "Bone morphogenetic protein 15", "gene_name": "BMP15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N4F0-1", "protein_name": "BPI fold-containing family B member 2", "gene_name": "BPIFB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19022-1", "protein_name": "Cadherin-2", "gene_name": "CDH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43852-1", "protein_name": "Calumenin", "gene_name": "CALU", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14515-1", "protein_name": "SPARC-like protein 1", "gene_name": "SPARCL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08253-1", "protein_name": "72 kDa type IV collagenase", "gene_name": "MMP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BRK3-1", "protein_name": "Matrix remodeling-associated protein 8", "gene_name": "MXRA8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16270-1", "protein_name": "Insulin-like growth factor-binding protein 7", "gene_name": "IGFBP7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96AD5-1", "protein_name": "Patatin-like phospholipase domain-containing protein 2", "gene_name": "PNPLA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05546-1", "protein_name": "Heparin cofactor 2", "gene_name": "SERPIND1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95084-1", "protein_name": "Serine protease 23", "gene_name": "PRSS23", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00391-1", "protein_name": "Sulfhydryl oxidase 1", "gene_name": "QSOX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15084-1", "protein_name": "Protein disulfide-isomerase A6", "gene_name": "PDIA6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15232-1", "protein_name": "Matrilin-3", "gene_name": "MATN3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76061-1", "protein_name": "Stanniocalcin-2", "gene_name": "STC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08582-1", "protein_name": "Melanotransferrin", "gene_name": "MELTF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N114-1", "protein_name": "Protein shisa-5", "gene_name": "SHISA5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09382-1", "protein_name": "Galectin-1", "gene_name": "LGALS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15293-1", "protein_name": "Reticulocalbin-1", "gene_name": "RCN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01024-1", "protein_name": "Complement C3", "gene_name": "C3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00255-2", "protein_name": "Menin", "gene_name": "MEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13316-1", "protein_name": "Dentin matrix acidic phosphoprotein 1", "gene_name": "DMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13217-1", "protein_name": "DnaJ homolog subfamily C member 3", "gene_name": "DNAJC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35555-1", "protein_name": "Fibrillin-1", "gene_name": "FBN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05060-1", "protein_name": "Secretogranin-1", "gene_name": "CHGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08833-1", "protein_name": "Insulin-like growth factor-binding protein 1", "gene_name": "IGFBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14314-1", "protein_name": "Glucosidase 2 subunit beta", "gene_name": "PRKCSH", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20718-1", "protein_name": "Granzyme H", "gene_name": "GZMH", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9GZV9-1", "protein_name": "Fibroblast growth factor 23", "gene_name": "FGF23", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18065-1", "protein_name": "Insulin-like growth factor-binding protein 2", "gene_name": "IGFBP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01344-1", "protein_name": "Insulin-like growth factor 2", "gene_name": "IGF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MK3-1", "protein_name": "Pseudokinase FAM20A", "gene_name": "FAM20A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05019-1", "protein_name": "Insulin-like growth factor 1", "gene_name": "IGF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24592-1", "protein_name": "Insulin-like growth factor-binding protein 6", "gene_name": "IGFBP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22692-1", "protein_name": "Insulin-like growth factor-binding protein 4", "gene_name": "IGFBP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08431-1", "protein_name": "Lactadherin", "gene_name": "MFGE8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55268-1", "protein_name": "Laminin subunit beta-2", "gene_name": "LAMB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ76-1", "protein_name": "Matrix extracellular phosphoglycoprotein", "gene_name": "MEPE", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM21-1", "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A", "gene_name": "MGAT4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24821-1", "protein_name": "Tenascin", "gene_name": "TNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76024-1", "protein_name": "Wolframin", "gene_name": "WFS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02771-1", "protein_name": "Alpha-fetoprotein", "gene_name": "AFP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14625-1", "protein_name": "Endoplasmin", "gene_name": "HSP90B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB0-1", "protein_name": "von Willebrand factor A domain-containing protein 1", "gene_name": "VWA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05067-1", "protein_name": "Amyloid-beta precursor protein", "gene_name": "APP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06481-1", "protein_name": "Amyloid beta precursor like protein 2", "gene_name": "APLP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14672-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02647-1", "protein_name": "Apolipoprotein A-I", "gene_name": "APOA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01009-1", "protein_name": "Alpha-1-antitrypsin", "gene_name": "SERPINA1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q14766", "url": "https://www.uniprot.org/uniprotkb/Q14766" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 734, "end_pos": 734, "sequence_org": "E", "sequence_mut": "Q", "comment": "Loss of activity.", "evidence": [ { "database": "UniProtKB", "id": "Q9BXP8", "url": "https://www.uniprot.org/uniprotkb/Q9BXP8" }, { "database": "PubMed", "id": "11264294", "url": "https://pubmed.ncbi.nlm.nih.gov/11264294" } ], "uniprot_canonical_ac": "Q9BXP8-1" } ], "record_id": "pubmed.11264294", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 124 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Mutagenesis of basic amino acids in the carboxyl-terminal region of insulin-like growth factor binding protein-5 affects acid-labile subunit binding.", "journal": "Endocrinology", "date": "2001", "authors": "Firth SM, Clemmons DR, Baxter RC", "reference": { "type": "PubMed", "id": "11316783", "url": "https://pubmed.ncbi.nlm.nih.gov/11316783" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q14766-1", "protein_name": "Latent-transforming growth factor beta-binding protein 1", "gene_name": "LTBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q24JP5-1", "protein_name": "Transmembrane protein 132A", "gene_name": "TMEM132A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00734-1", "protein_name": "Prothrombin", "gene_name": "F2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99217-1", "protein_name": "Amelogenin, X 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"SERPINC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UX39-1", "protein_name": "Amelotin", "gene_name": "AMTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01210-1", "protein_name": "Proenkephalin-A", "gene_name": "PENK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q02818-1", "protein_name": "Nucleobindin-1", "gene_name": "NUCB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q07065-1", "protein_name": "Cytoskeleton-associated protein 4", "gene_name": "CKAP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02765-1", "protein_name": "Alpha-2-HS-glycoprotein", "gene_name": "AHSG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02679-1", "protein_name": "Fibrinogen gamma chain", "gene_name": "FGG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07237-1", "protein_name": "Protein disulfide-isomerase", "gene_name": "P4HB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14393-2", "protein_name": "Growth arrest-specific protein 6", "gene_name": 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"BMP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95972-1", "protein_name": "Bone morphogenetic protein 15", "gene_name": "BMP15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N4F0-1", "protein_name": "BPI fold-containing family B member 2", "gene_name": "BPIFB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19022-1", "protein_name": "Cadherin-2", "gene_name": "CDH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43852-1", "protein_name": "Calumenin", "gene_name": "CALU", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14515-1", "protein_name": "SPARC-like protein 1", "gene_name": "SPARCL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08253-1", "protein_name": "72 kDa type IV collagenase", "gene_name": "MMP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BRK3-1", "protein_name": "Matrix remodeling-associated protein 8", "gene_name": "MXRA8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16270-1", "protein_name": "Insulin-like growth 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"protein_name": "Melanotransferrin", "gene_name": "MELTF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N114-1", "protein_name": "Protein shisa-5", "gene_name": "SHISA5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09382-1", "protein_name": "Galectin-1", "gene_name": "LGALS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15293-1", "protein_name": "Reticulocalbin-1", "gene_name": "RCN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01024-1", "protein_name": "Complement C3", "gene_name": "C3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00255-2", "protein_name": "Menin", "gene_name": "MEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13316-1", "protein_name": "Dentin matrix acidic phosphoprotein 1", "gene_name": "DMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13217-1", "protein_name": "DnaJ homolog subfamily C member 3", "gene_name": "DNAJC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35555-1", "protein_name": "Fibrillin-1", "gene_name": "FBN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05060-1", "protein_name": "Secretogranin-1", "gene_name": "CHGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08833-1", "protein_name": "Insulin-like growth factor-binding protein 1", "gene_name": "IGFBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14314-1", "protein_name": "Glucosidase 2 subunit beta", "gene_name": "PRKCSH", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20718-1", "protein_name": "Granzyme H", "gene_name": "GZMH", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9GZV9-1", "protein_name": "Fibroblast growth factor 23", "gene_name": "FGF23", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18065-1", "protein_name": "Insulin-like growth factor-binding protein 2", "gene_name": "IGFBP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01344-1", "protein_name": "Insulin-like growth factor 2", "gene_name": "IGF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MK3-1", "protein_name": "Pseudokinase FAM20A", "gene_name": "FAM20A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05019-1", "protein_name": "Insulin-like growth factor 1", "gene_name": "IGF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24592-1", "protein_name": "Insulin-like growth factor-binding protein 6", "gene_name": "IGFBP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22692-1", "protein_name": "Insulin-like growth factor-binding protein 4", "gene_name": "IGFBP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08431-1", "protein_name": "Lactadherin", "gene_name": "MFGE8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55268-1", "protein_name": "Laminin subunit beta-2", "gene_name": "LAMB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ76-1", "protein_name": "Matrix extracellular phosphoglycoprotein", "gene_name": "MEPE", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM21-1", "protein_name": "Alpha-1,3-mannosyl-glycoprotein 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"O14672-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02647-1", "protein_name": "Apolipoprotein A-I", "gene_name": "APOA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01009-1", "protein_name": "Alpha-1-antitrypsin", "gene_name": "SERPINA1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q14766", "url": "https://www.uniprot.org/uniprotkb/Q14766" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11316783", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 124 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": 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"glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Processing of immunosuppressive pro-TGF-beta 1,2 by human glioblastoma cells involves cytoplasmic and secreted furin-like proteases.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2001", "authors": "Leitlein J, Aulwurm S, Waltereit R, Naumann U, Wagenknecht B, Garten W, Weller M, Platten M", "reference": { "type": "PubMed", "id": "11390472", "url": "https://pubmed.ncbi.nlm.nih.gov/11390472" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q14766-1", "protein_name": "Latent-transforming 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"tax_name": "Human" }, { "uniprot_canonical_ac": "Q15843-1", "protein_name": "Ubiquitin-like protein NEDD8", "gene_name": "NEDD8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61081-1", "protein_name": "NEDD8-conjugating enzyme Ubc12", "gene_name": "UBE2M", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18564-1", "protein_name": "Integrin beta-6", "gene_name": "ITGB6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06756-1", "protein_name": "Integrin alpha-V", "gene_name": "ITGAV", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53708-1", "protein_name": "Integrin alpha-8", "gene_name": "ITGA8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36897-1", "protein_name": "TGF-beta receptor type-1", "gene_name": "TGFBR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62942-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP1A", "gene_name": "FKBP1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P84022-1", "protein_name": "SMAD family member 3", "gene_name": "SMAD3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05556-1", "protein_name": "Integrin beta-1", "gene_name": "ITGB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05106-1", "protein_name": "Integrin beta-3", "gene_name": "ITGB3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P37173-1", "protein_name": "TGF-beta receptor type-2", "gene_name": "TGFBR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P26012-1", "protein_name": "Integrin beta-8", "gene_name": "ITGB8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N2S1-1", "protein_name": "Latent-transforming growth factor beta-binding protein 4", "gene_name": "LTBP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35555-1", "protein_name": "Fibrillin-1", "gene_name": "FBN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q03167-1", "protein_name": "Transforming growth factor beta receptor type 3", "gene_name": "TGFBR3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01137-1", "protein_name": "Transforming growth factor beta-1 proprotein", "gene_name": "TGFB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61812-1", "protein_name": "Transforming growth factor beta-2 proprotein", "gene_name": "TGFB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22681-1", "protein_name": "E3 ubiquitin-protein ligase CBL", "gene_name": "CBL", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q14766", "url": "https://www.uniprot.org/uniprotkb/Q14766" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11390472", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 26 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": 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"uniprot_canonical_ac": "O00255-2", "protein_name": "Menin", "gene_name": "MEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13316-1", "protein_name": "Dentin matrix acidic phosphoprotein 1", "gene_name": "DMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13217-1", "protein_name": "DnaJ homolog subfamily C member 3", "gene_name": "DNAJC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35555-1", "protein_name": "Fibrillin-1", "gene_name": "FBN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05060-1", "protein_name": "Secretogranin-1", "gene_name": "CHGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08833-1", "protein_name": "Insulin-like growth factor-binding protein 1", "gene_name": "IGFBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14314-1", "protein_name": "Glucosidase 2 subunit beta", "gene_name": "PRKCSH", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20718-1", "protein_name": "Granzyme H", "gene_name": "GZMH", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9GZV9-1", "protein_name": "Fibroblast growth factor 23", "gene_name": "FGF23", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18065-1", "protein_name": "Insulin-like growth factor-binding protein 2", "gene_name": "IGFBP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01344-1", "protein_name": "Insulin-like growth factor 2", "gene_name": "IGF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MK3-1", "protein_name": "Pseudokinase FAM20A", "gene_name": "FAM20A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05019-1", "protein_name": "Insulin-like growth factor 1", "gene_name": "IGF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24592-1", "protein_name": "Insulin-like growth factor-binding protein 6", "gene_name": "IGFBP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22692-1", "protein_name": "Insulin-like growth factor-binding protein 4", "gene_name": "IGFBP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08431-1", "protein_name": "Lactadherin", "gene_name": "MFGE8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55268-1", "protein_name": "Laminin subunit beta-2", "gene_name": "LAMB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ76-1", "protein_name": "Matrix extracellular phosphoglycoprotein", "gene_name": "MEPE", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM21-1", "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A", "gene_name": "MGAT4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24821-1", "protein_name": "Tenascin", "gene_name": "TNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76024-1", "protein_name": "Wolframin", "gene_name": "WFS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02771-1", "protein_name": "Alpha-fetoprotein", "gene_name": "AFP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14625-1", "protein_name": "Endoplasmin", "gene_name": "HSP90B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB0-1", "protein_name": "von Willebrand factor A domain-containing protein 1", "gene_name": "VWA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05067-1", "protein_name": "Amyloid-beta precursor protein", "gene_name": "APP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06481-1", "protein_name": "Amyloid beta precursor like protein 2", "gene_name": "APLP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14672-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02647-1", "protein_name": "Apolipoprotein A-I", "gene_name": "APOA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01009-1", "protein_name": "Alpha-1-antitrypsin", "gene_name": "SERPINA1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q14766", "url": "https://www.uniprot.org/uniprotkb/Q14766" } ], "common_name": 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"tax_name": "Human" }, { "uniprot_canonical_ac": "Q15293-1", "protein_name": "Reticulocalbin-1", "gene_name": "RCN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01024-1", "protein_name": "Complement C3", "gene_name": "C3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00255-2", "protein_name": "Menin", "gene_name": "MEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13316-1", "protein_name": "Dentin matrix acidic phosphoprotein 1", "gene_name": "DMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13217-1", "protein_name": "DnaJ homolog subfamily C member 3", "gene_name": "DNAJC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35555-1", "protein_name": "Fibrillin-1", "gene_name": "FBN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05060-1", "protein_name": "Secretogranin-1", "gene_name": "CHGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08833-1", "protein_name": "Insulin-like growth factor-binding protein 1", "gene_name": "IGFBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14314-1", "protein_name": "Glucosidase 2 subunit beta", "gene_name": "PRKCSH", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20718-1", "protein_name": "Granzyme H", "gene_name": "GZMH", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9GZV9-1", "protein_name": "Fibroblast growth factor 23", "gene_name": "FGF23", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18065-1", "protein_name": "Insulin-like growth factor-binding protein 2", "gene_name": "IGFBP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01344-1", "protein_name": "Insulin-like growth factor 2", "gene_name": "IGF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MK3-1", "protein_name": "Pseudokinase FAM20A", "gene_name": "FAM20A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05019-1", "protein_name": "Insulin-like growth factor 1", "gene_name": "IGF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24592-1", "protein_name": "Insulin-like growth factor-binding protein 6", "gene_name": "IGFBP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22692-1", "protein_name": "Insulin-like growth factor-binding protein 4", "gene_name": "IGFBP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08431-1", "protein_name": "Lactadherin", "gene_name": "MFGE8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55268-1", "protein_name": "Laminin subunit beta-2", "gene_name": "LAMB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ76-1", "protein_name": "Matrix extracellular phosphoglycoprotein", "gene_name": "MEPE", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM21-1", "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A", "gene_name": "MGAT4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24821-1", "protein_name": "Tenascin", "gene_name": "TNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76024-1", "protein_name": "Wolframin", "gene_name": "WFS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02771-1", "protein_name": "Alpha-fetoprotein", "gene_name": "AFP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14625-1", "protein_name": "Endoplasmin", "gene_name": "HSP90B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB0-1", "protein_name": "von Willebrand factor A domain-containing protein 1", "gene_name": "VWA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05067-1", "protein_name": "Amyloid-beta precursor protein", "gene_name": "APP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06481-1", "protein_name": "Amyloid beta precursor like protein 2", "gene_name": "APLP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14672-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02647-1", "protein_name": "Apolipoprotein A-I", "gene_name": "APOA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01009-1", "protein_name": 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"Pseudokinase FAM20A", "gene_name": "FAM20A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05019-1", "protein_name": "Insulin-like growth factor 1", "gene_name": "IGF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24592-1", "protein_name": "Insulin-like growth factor-binding protein 6", "gene_name": "IGFBP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22692-1", "protein_name": "Insulin-like growth factor-binding protein 4", "gene_name": "IGFBP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08431-1", "protein_name": "Lactadherin", "gene_name": "MFGE8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55268-1", "protein_name": "Laminin subunit beta-2", "gene_name": "LAMB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ76-1", "protein_name": "Matrix extracellular phosphoglycoprotein", "gene_name": "MEPE", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM21-1", "protein_name": "Alpha-1,3-mannosyl-glycoprotein 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"P05067-1", "protein_name": "Amyloid-beta precursor protein", "gene_name": "APP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06481-1", "protein_name": "Amyloid beta precursor like protein 2", "gene_name": "APLP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14672-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02647-1", "protein_name": "Apolipoprotein A-I", "gene_name": "APOA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01009-1", "protein_name": "Alpha-1-antitrypsin", "gene_name": "SERPINA1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q14766", "url": "https://www.uniprot.org/uniprotkb/Q14766" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11788658", "abstract": "", "glycosylation": [], 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"field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis.", "journal": "The Biochemical journal", "date": "2002", "authors": "Laursen LS, Overgaard MT, Nielsen CG, Boldt HB, Hopmann KH, Conover CA, Sottrup-Jensen L, Giudice LC, Oxvig C", "reference": { "type": "PubMed", "id": "12241545", "url": "https://pubmed.ncbi.nlm.nih.gov/12241545" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q14766-1", "protein_name": "Latent-transforming growth factor beta-binding protein 1", "gene_name": "LTBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q24JP5-1", "protein_name": "Transmembrane protein 132A", "gene_name": "TMEM132A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00734-1", "protein_name": "Prothrombin", "gene_name": "F2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99217-1", "protein_name": "Amelogenin, X isoform", "gene_name": "AMELX", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02671-1", "protein_name": "Fibrinogen alpha chain", "gene_name": "FGA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q12841-1", "protein_name": 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inhibitor heavy chain H2", "gene_name": "ITIH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13103-1", "protein_name": "Secreted phosphoprotein 24", "gene_name": "SPP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15240-1", "protein_name": "Neurosecretory protein VGF", "gene_name": "VGF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BU40-6", "protein_name": "Chordin-like protein 1", "gene_name": "CHRDL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24593-1", "protein_name": "Insulin-like growth factor-binding protein 5", "gene_name": "IGFBP5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14703-1", "protein_name": "Membrane-bound transcription factor site-1 protease", "gene_name": "MBTPS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BXP8-1", "protein_name": "Pappalysin-2", "gene_name": "PAPPA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02652-1", "protein_name": "Apolipoprotein A-II", "gene_name": "APOA2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NBP7-1", "protein_name": "Proprotein convertase subtilisin/kexin type 9", "gene_name": "PCSK9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IXL6-1", "protein_name": "Extracellular serine/threonine protein kinase FAM20C", "gene_name": "FAM20C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35858-1", "protein_name": "Insulin-like growth factor-binding protein complex acid labile subunit", "gene_name": "IGFALS", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6Q788-1", "protein_name": "Apolipoprotein A-V", "gene_name": "APOA5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00747-1", "protein_name": "Plasminogen", "gene_name": "PLG", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02768-1", "protein_name": "Albumin", "gene_name": "ALB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07288-1", "protein_name": "Prostate-specific antigen", "gene_name": "KLK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NP70-1", "protein_name": 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"Human" }, { "uniprot_canonical_ac": "P05546-1", "protein_name": "Heparin cofactor 2", "gene_name": "SERPIND1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95084-1", "protein_name": "Serine protease 23", "gene_name": "PRSS23", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00391-1", "protein_name": "Sulfhydryl oxidase 1", "gene_name": "QSOX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15084-1", "protein_name": "Protein disulfide-isomerase A6", "gene_name": "PDIA6", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15232-1", "protein_name": "Matrilin-3", "gene_name": "MATN3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76061-1", "protein_name": "Stanniocalcin-2", "gene_name": "STC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08582-1", "protein_name": "Melanotransferrin", "gene_name": "MELTF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N114-1", "protein_name": "Protein shisa-5", "gene_name": "SHISA5", "tax_name": "Human" }, { "uniprot_canonical_ac": "P09382-1", "protein_name": "Galectin-1", "gene_name": "LGALS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15293-1", "protein_name": "Reticulocalbin-1", "gene_name": "RCN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01024-1", "protein_name": "Complement C3", "gene_name": "C3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00255-2", "protein_name": "Menin", "gene_name": "MEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13316-1", "protein_name": "Dentin matrix acidic phosphoprotein 1", "gene_name": "DMP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13217-1", "protein_name": "DnaJ homolog subfamily C member 3", "gene_name": "DNAJC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35555-1", "protein_name": "Fibrillin-1", "gene_name": "FBN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05060-1", "protein_name": "Secretogranin-1", "gene_name": "CHGB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P08833-1", "protein_name": "Insulin-like growth factor-binding protein 1", "gene_name": "IGFBP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14314-1", "protein_name": "Glucosidase 2 subunit beta", "gene_name": "PRKCSH", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20718-1", "protein_name": "Granzyme H", "gene_name": "GZMH", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9GZV9-1", "protein_name": "Fibroblast growth factor 23", "gene_name": "FGF23", "tax_name": "Human" }, { "uniprot_canonical_ac": "P18065-1", "protein_name": "Insulin-like growth factor-binding protein 2", "gene_name": "IGFBP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01344-1", "protein_name": "Insulin-like growth factor 2", "gene_name": "IGF2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96MK3-1", "protein_name": "Pseudokinase FAM20A", "gene_name": "FAM20A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05019-1", "protein_name": "Insulin-like growth factor 1", "gene_name": "IGF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24592-1", "protein_name": "Insulin-like growth factor-binding protein 6", "gene_name": "IGFBP6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22692-1", "protein_name": "Insulin-like growth factor-binding protein 4", "gene_name": "IGFBP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08431-1", "protein_name": "Lactadherin", "gene_name": "MFGE8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55268-1", "protein_name": "Laminin subunit beta-2", "gene_name": "LAMB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ76-1", "protein_name": "Matrix extracellular phosphoglycoprotein", "gene_name": "MEPE", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UM21-1", "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A", "gene_name": "MGAT4A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24821-1", "protein_name": "Tenascin", "gene_name": "TNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76024-1", "protein_name": "Wolframin", "gene_name": "WFS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02771-1", "protein_name": "Alpha-fetoprotein", "gene_name": "AFP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14625-1", "protein_name": "Endoplasmin", "gene_name": "HSP90B1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6PCB0-1", "protein_name": "von Willebrand factor A domain-containing protein 1", "gene_name": "VWA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05067-1", "protein_name": "Amyloid-beta precursor protein", "gene_name": "APP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06481-1", "protein_name": "Amyloid beta precursor like protein 2", "gene_name": "APLP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14672-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02647-1", "protein_name": "Apolipoprotein A-I", "gene_name": "APOA1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01009-1", "protein_name": "Alpha-1-antitrypsin", "gene_name": "SERPINA1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q14766", "url": "https://www.uniprot.org/uniprotkb/Q14766" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.12241545", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 124 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] } ]