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Sci.", "date": "2006", "authors": "Takai T, Takaya T, Nakano M, Akutsu H, Nakagawa A, Aimoto S, Nagai K, Ikegami T", "reference": { "type": "PubMed", "id": "16429482", "url": "https://pubmed.ncbi.nlm.nih.gov/16429482" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43612-1", "protein_name": "Hypocretin neuropeptide precursor", "gene_name": "HCRT", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43613-1", "protein_name": "Orexin/Hypocretin receptor type 1", "gene_name": "HCRTR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15130-1", "protein_name": "Pro-FMRFamide-related neuropeptide FF", "gene_name": "NPFF", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9GZQ6-1", "protein_name": "Neuropeptide FF receptor 1", "gene_name": "NPFFR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5X5-1", "protein_name": "Neuropeptide FF receptor 2", "gene_name": "NPFFR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43614-1", "protein_name": 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Genet.", "date": "1999", "authors": "Tentler D, Gustavsson P, Leisti J, Schueler M, Chelly J, Timonen E, Anner\u00e9n G, Willard H F, Dahl N", "reference": { "type": "PubMed", "id": "10439959", "url": "https://pubmed.ncbi.nlm.nih.gov/10439959" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O60890-1", "protein_name": "Oligophrenin-1", "gene_name": "OPHN1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O60890", "url": "https://www.uniprot.org/uniprotkb/O60890" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10439959", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Determination of the gene structure of human oligophrenin-1 and identification of three novel polymorphisms by screening of DNA from 164 patients with non-specific X-linked mental retardation.", "journal": "Ann. 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Receptor Mediates Neurogenic Inflammation and Pain.", "journal": "Neuron", "date": "2019", "authors": "Green DP, Limjunyawong N, Gour N, Pundir P, Dong X", "reference": { "type": "PubMed", "id": "30686732", "url": "https://pubmed.ncbi.nlm.nih.gov/30686732" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P20366-1", "protein_name": "Protachykinin-1", "gene_name": "TAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96LB1-1", "protein_name": "Mas-related G protein-coupled receptor member X2", "gene_name": "MRGPRX2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P41539-1", "protein_name": "Protachykinin-1", "gene_name": "Tac1", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q3KNA1-1", "protein_name": "Mas-related G protein-coupled receptor member B2", "gene_name": "Mrgprb2", "tax_name": "Mouse" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P20366", "url": 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], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "p66alpha Suppresses Breast Cancer Cell Growth and Migration by Acting as Co-Activator of p53.", "journal": "Cells", "date": "2021", "authors": "Zhang Q, Zhang Y, Zhang J, Zhang D, Li M, Yan H, Zhang H, Song L, Wang J, Hou Z, Yang Y, Zou X", "reference": { "type": "PubMed", "id": "34944103", "url": "https://pubmed.ncbi.nlm.nih.gov/34944103" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q86YP4-1", "protein_name": "Transcriptional repressor p66-alpha", "gene_name": 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "lncKRT16P6 promotes tongue squamous cell carcinoma progression by sponging miR\u20113180 and regulating GATAD2A expression.", "journal": "International journal of oncology", "date": "2022", "authors": "Zhang M, Wu L, Wang X, Chen J", "reference": { "type": "PubMed", "id": "35904180", "url": "https://pubmed.ncbi.nlm.nih.gov/35904180" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q86YP4-1", "protein_name": "Transcriptional repressor p66-alpha", "gene_name": "GATAD2A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q86YP4", "url": "https://www.uniprot.org/uniprotkb/Q86YP4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.35904180", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], 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Commun.", "date": "2021", "authors": "Cipullo Miriam, Ges\u00e9 Gen\u00eds Valent\u00edn, Khawaja Anas, H\u00e4llberg B Martin, Rorbach Joanna", "reference": { "type": "PubMed", "id": "34135318", "url": "https://pubmed.ncbi.nlm.nih.gov/34135318" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9NWU5-1", "protein_name": "Large ribosomal subunit protein uL22m", "gene_name": "MRPL22", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NWU5", "url": "https://www.uniprot.org/uniprotkb/Q9NWU5" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.34135318", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", 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"o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Endogenous peptides with distinct amino acid anchor residue motifs bind to HLA-A1 and HLA-B8.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "1994-01-15", "authors": "DiBrino M, Parker K C, Shiloach J, Turner R V, Tsuchida T, Garfield M, Biddison W E, Coligan J E", "reference": { "type": "PubMed", "id": "7506728", "url": "https://pubmed.ncbi.nlm.nih.gov/7506728" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q07020-1", "protein_name": "Large ribosomal subunit protein eL18", "gene_name": "RPL18", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22087-1", "protein_name": "rRNA 2'-O-methyltransferase fibrillarin", "gene_name": "FBL", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62249-1", "protein_name": "Small ribosomal subunit protein uS9", "gene_name": 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Biophys. 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"L22 ribosomal protein is involved in dynamin-related protein 1-mediated gastric carcinoma progression.", "journal": "Bioengineered", "date": "2022", "authors": "Cheng J, Sha Z, Zhang R, Ge J, Chen P, Kuang X, Chang J, Ren K, Luo X, Chen S, Gou X", "reference": { "type": "PubMed", "id": "35230214", "url": "https://pubmed.ncbi.nlm.nih.gov/35230214" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P35268-1", "protein_name": "Large ribosomal subunit protein eL22", "gene_name": "RPL22", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P35268", "url": "https://www.uniprot.org/uniprotkb/P35268" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.35230214", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": 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Biophys. Res. Commun.", "date": "1994", "authors": "Fujita Y, Okamoto T, Noshiro M, McKeehan WL, Crabb JW, Whitney RG, Kato Y, Sato JD, Takada K", "reference": { "type": "PubMed", "id": "8135813", "url": "https://pubmed.ncbi.nlm.nih.gov/8135813" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P35268-1", "protein_name": "Large ribosomal subunit protein eL22", "gene_name": "RPL22", "tax_name": "Human" }, { "uniprot_canonical_ac": "P67985-1", "protein_name": "Large ribosomal subunit protein eL22", "gene_name": "RPL22", "tax_name": "Pig" }, { "uniprot_canonical_ac": "P67984-1", "protein_name": "Large ribosomal subunit protein eL22", "gene_name": "Rpl22", "tax_name": "Mouse" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P35268", "url": "https://www.uniprot.org/uniprotkb/P35268" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.8135813", 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AL, Denis C, Lantoine D, Kerckaert JP, Galiegue-Zouitina S", "reference": { "type": "PubMed", "id": "15563831", "url": "https://pubmed.ncbi.nlm.nih.gov/15563831" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q15669-1", "protein_name": "Rho-related GTP-binding protein RhoH", "gene_name": "RHOH", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q15669", "url": "https://www.uniprot.org/uniprotkb/Q15669" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.15563831", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", 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"o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Xu BE, Stippec S, Lazrak A, Huang CL, Cobb MH", "reference": { "type": "PubMed", "id": "16081417", "url": "https://pubmed.ncbi.nlm.nih.gov/16081417" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9H4A3-1", "protein_name": "Serine/threonine-protein kinase WNK1", "gene_name": "WNK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9JIH7-1", "protein_name": "Serine/threonine-protein kinase WNK1", "gene_name": "Wnk1", "tax_name": "Rat" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9H4A3", "url": "https://www.uniprot.org/uniprotkb/Q9H4A3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "phosphorylation": [ { "start_pos": 60, "end_pos": 60, "kinase_uniprot_canonical_ac": "P31749-1", "kinase_gene_name": "AKT1", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q9H4A3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9H4A3" }, { "database": "PubMed", "id": "14611643", "url": "https://pubmed.ncbi.nlm.nih.gov/14611643" }, { "database": "PubMed", "id": "16081417", "url": "https://pubmed.ncbi.nlm.nih.gov/16081417" } ], "site_lbl": "Thr60", "uniprot_canonical_ac": "Q9H4A3-1" }, { "start_pos": 58, "end_pos": 58, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "Q9JIH7", "url": "https://www.uniprot.org/uniprotkb/Q9JIH7" }, { "database": "PubMed", "id": "16081417", "url": "https://pubmed.ncbi.nlm.nih.gov/16081417" }, { "database": "iPTMnet", "id": "Q9JIH7", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9JIH7" } ], "site_lbl": "Thr58", "uniprot_canonical_ac": "Q9JIH7-1" } ], "mutagenesis": [ { "start_pos": 58, "end_pos": 58, "sequence_org": "T", "sequence_mut": "A", "comment": "Decreased ability to activate SGK1.", "evidence": [ { "database": "UniProtKB", "id": "Q9JIH7", "url": "https://www.uniprot.org/uniprotkb/Q9JIH7" }, { "database": "PubMed", "id": "16081417", "url": "https://pubmed.ncbi.nlm.nih.gov/16081417" } ], "uniprot_canonical_ac": "Q9JIH7-1" } ], "record_id": "pubmed.16081417", "abstract": "", "glycosylation": [], "snv": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl", "uniprot_canonical_ac" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H", "reference": { "type": "PubMed", "id": "16263722", "url": "https://pubmed.ncbi.nlm.nih.gov/16263722" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9H4A3-1", "protein_name": "Serine/threonine-protein kinase WNK1", "gene_name": "WNK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UEW8-1", "protein_name": "STE20/SPS1-related proline-alanine-rich protein kinase", "gene_name": "STK39", "tax_name": "Human" }, { "uniprot_canonical_ac": "P59158-1", "protein_name": "Solute carrier family 12 member 3", "gene_name": "Slc12a3", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q6P9R2-1", "protein_name": "Serine/threonine-protein kinase OSR1", "gene_name": "Oxsr1", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "O88506-1", "protein_name": "STE20/SPS1-related proline-alanine-rich protein kinase", "gene_name": "Stk39", "tax_name": "Rat" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9H4A3", "url": "https://www.uniprot.org/uniprotkb/Q9H4A3" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 1258, "end_pos": 1258, "sequence_org": "F", "sequence_mut": "A", "comment": "Slightly decreased binding to OXSR1/OSR1 and STK39/SPAK; when associated with A-1860. Abolished binding to OXSR1/OSR1 and STK39/SPAK; when associated with A-1860, A-1946 and A-1958.", "evidence": [ { "database": "UniProtKB", "id": "Q9H4A3", "url": "https://www.uniprot.org/uniprotkb/Q9H4A3" }, { "database": "PubMed", "id": "16263722", "url": "https://pubmed.ncbi.nlm.nih.gov/16263722" } ], "uniprot_canonical_ac": "Q9H4A3-1" }, { "start_pos": 1860, "end_pos": 1860, "sequence_org": "F", "sequence_mut": "A", "comment": "Slightly decreased binding to OXSR1/OSR1 and STK39/SPAK; when associated with A-1258. Abolished binding to OXSR1/OSR1 and STK39/SPAK; when associated with A-1258, A-1946 and A-1958.", "evidence": [ { "database": "UniProtKB", "id": "Q9H4A3", "url": "https://www.uniprot.org/uniprotkb/Q9H4A3" }, { "database": "PubMed", "id": "16263722", "url": "https://pubmed.ncbi.nlm.nih.gov/16263722" } ], "uniprot_canonical_ac": "Q9H4A3-1" }, { "start_pos": 1946, "end_pos": 1946, "sequence_org": "F", "sequence_mut": "A", "comment": "Slightly decreased binding to OXSR1/OSR1 and STK39/SPAK; when associated with A-1958. Abolished binding to OXSR1/OSR1 and STK39/SPAK; when associated with A-1257, A-1860 and A-1958.", "evidence": [ { "database": "UniProtKB", "id": "Q9H4A3", "url": "https://www.uniprot.org/uniprotkb/Q9H4A3" }, { "database": "PubMed", "id": "16263722", "url": "https://pubmed.ncbi.nlm.nih.gov/16263722" } ], "uniprot_canonical_ac": "Q9H4A3-1" }, { "start_pos": 1958, "end_pos": 1958, "sequence_org": "F", "sequence_mut": "A", "comment": "Slightly decreased binding to OXSR1/OSR1 and STK39/SPAK; when associated with A-1946. Abolished binding to OXSR1/OSR1 and STK39/SPAK; when associated with A-1258, A-1860 and A-1946.", "evidence": [ { "database": "UniProtKB", "id": "Q9H4A3", "url": "https://www.uniprot.org/uniprotkb/Q9H4A3" }, { "database": "PubMed", "id": "16263722", "url": "https://pubmed.ncbi.nlm.nih.gov/16263722" } ], "uniprot_canonical_ac": "Q9H4A3-1" }, { "start_pos": 233, "end_pos": 233, "sequence_org": "K", "sequence_mut": "M", "comment": "Abolished serine/threonine-protein kinase activity. Does not affect ability to activate SGK1.", "evidence": [ { "database": "UniProtKB", "id": "Q9H4A3", "url": "https://www.uniprot.org/uniprotkb/Q9H4A3" }, { "database": "PubMed", "id": "16263722", "url": "https://pubmed.ncbi.nlm.nih.gov/16263722" }, { "database": "PubMed", "id": "36373794", "url": "https://pubmed.ncbi.nlm.nih.gov/36373794" } ], "uniprot_canonical_ac": "Q9H4A3-1" }, { "start_pos": 368, "end_pos": 368, "sequence_org": "D", "sequence_mut": "A", "comment": "Abolished serine/threonine-protein kinase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q9H4A3", "url": "https://www.uniprot.org/uniprotkb/Q9H4A3" }, { "database": "PubMed", "id": "17190791", "url": "https://pubmed.ncbi.nlm.nih.gov/17190791" }, { "database": "PubMed", "id": "16263722", "url": "https://pubmed.ncbi.nlm.nih.gov/16263722" } ], "uniprot_canonical_ac": "Q9H4A3-1" }, { "start_pos": 382, "end_pos": 382, "sequence_org": "S", "sequence_mut": "A", "comment": "Decreased autophosphorylation, preventing activation of the serine/threonine-protein kinase activity.", "evidence": [ { "database": "UniProtKB", "id": "Q9H4A3", "url": "https://www.uniprot.org/uniprotkb/Q9H4A3" }, { "database": "PubMed", "id": "16832045", "url": "https://pubmed.ncbi.nlm.nih.gov/16832045" }, { "database": "PubMed", "id": "17190791", "url": "https://pubmed.ncbi.nlm.nih.gov/17190791" }, { "database": "PubMed", "id": "16263722", "url": "https://pubmed.ncbi.nlm.nih.gov/16263722" } ], "uniprot_canonical_ac": "Q9H4A3-1" }, { "start_pos": 53, "end_pos": 53, "sequence_org": "T", "sequence_mut": "A", "comment": "Reduced phosphorylation by OXSR1/OSR1 and STK39/SPAK; when associated with A-58 and A-71. Substantial reduction in MAPK1/3 (ERK1/2) phosphorylation in response to IL18, with or without IL12.", "evidence": [ { "database": "UniProtKB", "id": "P59158", "url": "https://www.uniprot.org/uniprotkb/P59158" }, { "database": "PubMed", "id": "26099046", "url": "https://pubmed.ncbi.nlm.nih.gov/26099046" }, { "database": "PubMed", "id": "16263722", "url": "https://pubmed.ncbi.nlm.nih.gov/16263722" } ], "uniprot_canonical_ac": "P59158-1" }, { "start_pos": 58, "end_pos": 58, "sequence_org": "T", "sequence_mut": "A", "comment": "Reduced phosphorylation by OXSR1/OSR1 and STK39/SPAK; when associated with A-53 and A-71. No effect on MAPK1/3 (ERK1/2) phosphorylation in response to IL18, with or without IL12. Substantial reduction in MAPK1/3 (ERK1/2) phosphorylation in response to IL18, with or without IL12; when associated with A-53 and A-71.", "evidence": [ { "database": "UniProtKB", "id": "P59158", "url": "https://www.uniprot.org/uniprotkb/P59158" }, { "database": "PubMed", "id": "26099046", "url": "https://pubmed.ncbi.nlm.nih.gov/26099046" }, { "database": "PubMed", "id": "16263722", "url": "https://pubmed.ncbi.nlm.nih.gov/16263722" } ], "uniprot_canonical_ac": "P59158-1" }, { "start_pos": 71, "end_pos": 71, "sequence_org": "S", "sequence_mut": "A", "comment": "Reduced phosphorylation by OXSR1/OSR1 and STK39/SPAK; when associated with A-53 and A-58. No effect on MAPK1/3 (ERK1/2) phosphorylation in response to IL18, with or without IL12. Substantial reduction in MAPK1/3 (ERK1/2) phosphorylation in response to IL18, with or without IL12; when associated with A-53 and A-58.", "evidence": [ { "database": "UniProtKB", "id": "P59158", "url": "https://www.uniprot.org/uniprotkb/P59158" }, { "database": "PubMed", "id": "26099046", "url": "https://pubmed.ncbi.nlm.nih.gov/26099046" }, { "database": "PubMed", "id": "16263722", "url": "https://pubmed.ncbi.nlm.nih.gov/16263722" } ], "uniprot_canonical_ac": "P59158-1" }, { "start_pos": 380, "end_pos": 380, "sequence_org": "S", "sequence_mut": "A", "comment": "Decreased phosphorylation by WNK1.", "evidence": [ { "database": "UniProtKB", "id": "O88506", "url": "https://www.uniprot.org/uniprotkb/O88506" }, { "database": "PubMed", "id": "16263722", "url": "https://pubmed.ncbi.nlm.nih.gov/16263722" } ], "uniprot_canonical_ac": "O88506-1" } ], "phosphorylation": [ { "start_pos": 382, "end_pos": 382, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by autocatalysis", "evidence": [ { "database": "UniProtKB", "id": "Q9H4A3", "url": "https://www.uniprot.org/uniprotkb/Q9H4A3" }, { "database": "iPTMnet", "id": "Q9H4A3", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9H4A3" }, { "database": "PubMed", "id": "12374799", "url": "https://pubmed.ncbi.nlm.nih.gov/12374799" }, { "database": "PubMed", "id": "17190791", "url": "https://pubmed.ncbi.nlm.nih.gov/17190791" }, { "database": "PubMed", "id": "22032326", "url": "https://pubmed.ncbi.nlm.nih.gov/22032326" }, { "database": "PubMed", "id": "29176664", "url": "https://pubmed.ncbi.nlm.nih.gov/29176664" }, { "database": "PubMed", "id": "31656913", "url": "https://pubmed.ncbi.nlm.nih.gov/31656913" }, { "database": "PubMed", "id": "16263722", "url": "https://pubmed.ncbi.nlm.nih.gov/16263722" }, { "database": "PubMed", "id": "16832045", "url": "https://pubmed.ncbi.nlm.nih.gov/16832045" }, { "database": "PubMed", "id": "34289367", "url": "https://pubmed.ncbi.nlm.nih.gov/34289367" } ], "site_lbl": "Ser382", "uniprot_canonical_ac": "Q9H4A3-1" }, { "start_pos": 231, "end_pos": 231, "kinase_uniprot_canonical_ac": "Q9H4A3-1", "kinase_gene_name": "WNK1", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q9UEW8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9UEW8" }, { "database": "PubMed", "id": "16083423", "url": "https://pubmed.ncbi.nlm.nih.gov/16083423" }, { "database": "PubMed", "id": "16263722", "url": "https://pubmed.ncbi.nlm.nih.gov/16263722" }, { "database": "PubMed", "id": "17190791", "url": "https://pubmed.ncbi.nlm.nih.gov/17190791" } ], "site_lbl": "Thr231", "uniprot_canonical_ac": "Q9UEW8-1" }, { "start_pos": 371, "end_pos": 371, "kinase_uniprot_canonical_ac": "Q9H4A3-1", "kinase_gene_name": "WNK1", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q9UEW8", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q9UEW8" }, { "database": "PubMed", "id": "16083423", "url": "https://pubmed.ncbi.nlm.nih.gov/16083423" }, { "database": "PubMed", "id": "16263722", "url": "https://pubmed.ncbi.nlm.nih.gov/16263722" }, { "database": "PubMed", "id": "17190791", "url": "https://pubmed.ncbi.nlm.nih.gov/17190791" }, { "database": "PubMed", "id": "18270262", "url": "https://pubmed.ncbi.nlm.nih.gov/18270262" } ], "site_lbl": "Ser371", "uniprot_canonical_ac": "Q9UEW8-1" }, { "start_pos": 53, "end_pos": 53, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "P59158", "url": "https://www.uniprot.org/uniprotkb/P59158" }, { "database": "PubMed", "id": "16263722", "url": "https://pubmed.ncbi.nlm.nih.gov/16263722" }, { "database": "PubMed", "id": "21183079", "url": "https://pubmed.ncbi.nlm.nih.gov/21183079" }, { "database": "iPTMnet", "id": "P59158", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P59158" }, { 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