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    {
        "title": "C-terminal Src kinase associates with ligand-stimulated insulin-like growth factor-I receptor.",
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        "date": "1999-02-26",
        "authors": "Arbet-Engels C, Tartare-Deckert S, Eckhart W",
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                "name": "Homo sapiens",
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                ],
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        ],
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            {
                "start_pos": 1346,
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                    {
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                    },
                    {
                        "database": "PubMed",
                        "id": "8550552",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/8550552"
                    },
                    {
                        "database": "IntAct",
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                    {
                        "database": "PubMed",
                        "id": "10026153",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/10026153"
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                    {
                        "database": "PubMed",
                        "id": "7589433",
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                    {
                        "database": "PubMed",
                        "id": "7642582",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/7642582"
                    },
                    {
                        "database": "PubMed",
                        "id": "8895367",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/8895367"
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                    {
                        "database": "PubMed",
                        "id": "9415396",
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                    {
                        "database": "PubMed",
                        "id": "8603569",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/8603569"
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                ],
                "site_lbl": "Tyr1346",
                "uniprot_canonical_ac": "P08069-1"
            },
            {
                "start_pos": 973,
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                "kinase_gene_name": "",
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                "comment": "",
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                    {
                        "database": "IntAct",
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                        "url": "https://www.ebi.ac.uk/intact/interactors/id:P08069*"
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                    {
                        "database": "iPTMnet",
                        "id": "P08069",
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                        "database": "PubMed",
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                    {
                        "database": "PubMed",
                        "id": "9480911",
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                ],
                "site_lbl": "Tyr973",
                "uniprot_canonical_ac": "P08069-1"
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        ],
        "record_id": "pubmed.10026153",
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            {
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                        "field": "n_linked_glycans",
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                        "field": "o_linked_sites",
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                        "field": "n_linked_glycan_sites",
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                    {
                        "field": "o_linked_glycan_sites",
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                    {
                        "field": "n_linked_glycans",
                        "count": 0
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                    {
                        "field": "o_linked_glycans",
                        "count": 0
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                ],
                "sort_fields": []
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        ]
    },
    {
        "title": "Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis.",
        "journal": "Molecular and cellular biology",
        "date": "1999",
        "authors": "Wang J, Dai H, Yousaf N, Moussaif M, Deng Y, Boufelliga A, Swamy OR, Leone ME, Riedel H",
        "reference": {
            "type": "PubMed",
            "id": "10454568",
            "url": "https://pubmed.ncbi.nlm.nih.gov/10454568"
        },
        "referenced_glycans": [],
        "referenced_proteins": [
            {
                "uniprot_canonical_ac": "P08069-1",
                "protein_name": "Insulin-like growth factor 1 receptor",
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                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q60760-1",
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                "tax_name": "Mouse"
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            {
                "uniprot_canonical_ac": "P11362-1",
                "protein_name": "Fibroblast growth factor receptor 1",
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                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P05622-1",
                "protein_name": "Platelet-derived growth factor receptor beta",
                "gene_name": "Pdgfrb",
                "tax_name": "Mouse"
            },
            {
                "uniprot_canonical_ac": "P09619-1",
                "protein_name": "Platelet-derived growth factor receptor beta",
                "gene_name": "PDGFRB",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P08581-1",
                "protein_name": "Hepatocyte growth factor receptor",
                "gene_name": "MET",
                "tax_name": "Human"
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        ],
        "species": [
            {
                "name": "Homo sapiens",
                "taxid": 9606,
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P08069",
                        "url": "https://www.uniprot.org/uniprotkb/P08069"
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                ],
                "common_name": "Human",
                "glygen_name": "Human",
                "reference_species": "Homo sapiens [9606]"
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        ],
        "mutagenesis": [
            {
                "start_pos": 1280,
                "end_pos": 1280,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "No effect on GRB10-binding.",
                "evidence": [
                    {
                        "database": "UniProtKB",
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                    {
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                        "id": "10454568",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/10454568"
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                ],
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            },
            {
                "start_pos": 1281,
                "end_pos": 1281,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "No effect on GRB10-binding.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P08069",
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                    },
                    {
                        "database": "PubMed",
                        "id": "10454568",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/10454568"
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                ],
                "uniprot_canonical_ac": "P08069-1"
            },
            {
                "start_pos": 1346,
                "end_pos": 1346,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "Loss of GRB10-binding.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P08069",
                        "url": "https://www.uniprot.org/uniprotkb/P08069"
                    },
                    {
                        "database": "PubMed",
                        "id": "10454568",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/10454568"
                    }
                ],
                "uniprot_canonical_ac": "P08069-1"
            },
            {
                "start_pos": 980,
                "end_pos": 980,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "Reduces tyrosine phosphorylation. Abolishes interaction with IRS1 and SHC1. Does not abolish interaction with PIK3R1, nor with GRB10.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P08069",
                        "url": "https://www.uniprot.org/uniprotkb/P08069"
                    },
                    {
                        "database": "PubMed",
                        "id": "7541045",
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                    },
                    {
                        "database": "PubMed",
                        "id": "10454568",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/10454568"
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                ],
                "uniprot_canonical_ac": "P08069-1"
            },
            {
                "start_pos": 1009,
                "end_pos": 1009,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "No effect on interaction with GRB10. Abolishes interaction with PLCG1; when associated with F-1021.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P09619",
                        "url": "https://www.uniprot.org/uniprotkb/P09619"
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                    {
                        "database": "PubMed",
                        "id": "1396585",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/1396585"
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                    {
                        "database": "PubMed",
                        "id": "7691811",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/7691811"
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                    {
                        "database": "PubMed",
                        "id": "10454568",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/10454568"
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                ],
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            },
            {
                "start_pos": 1021,
                "end_pos": 1021,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "Strongly reduces up-regulation of cell proliferation. Abolishes interaction with PLCG1; when associated with F-1009. No effect on interaction with GRB10.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P09619",
                        "url": "https://www.uniprot.org/uniprotkb/P09619"
                    },
                    {
                        "database": "PubMed",
                        "id": "21679854",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/21679854"
                    },
                    {
                        "database": "PubMed",
                        "id": "1396585",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/1396585"
                    },
                    {
                        "database": "PubMed",
                        "id": "17620338",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/17620338"
                    },
                    {
                        "database": "PubMed",
                        "id": "10454568",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/10454568"
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                ],
                "uniprot_canonical_ac": "P09619-1"
            },
            {
                "start_pos": 579,
                "end_pos": 579,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "Loss of kinase activity; when associated with F-581. Strongly reduces interaction with SRC family kinases. No effect on interaction with GRB10.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P09619",
                        "url": "https://www.uniprot.org/uniprotkb/P09619"
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                    {
                        "database": "PubMed",
                        "id": "7685273",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/7685273"
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                    {
                        "database": "PubMed",
                        "id": "10454568",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/10454568"
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                ],
                "uniprot_canonical_ac": "P09619-1"
            },
            {
                "start_pos": 581,
                "end_pos": 581,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "Loss of kinase activity; when associated with F-579. No effect on interaction with GRB10.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P09619",
                        "url": "https://www.uniprot.org/uniprotkb/P09619"
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                    {
                        "database": "PubMed",
                        "id": "7685273",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/7685273"
                    },
                    {
                        "database": "PubMed",
                        "id": "10454568",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/10454568"
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                ],
                "uniprot_canonical_ac": "P09619-1"
            },
            {
                "start_pos": 716,
                "end_pos": 716,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "No effect neither on interaction with GRB10 and RASA1 nor on phosphatidylinositol 3-kinase activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P09619",
                        "url": "https://www.uniprot.org/uniprotkb/P09619"
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                        "database": "PubMed",
                        "id": "1314164",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/1314164"
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