[
    {
        "title": "Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein.",
        "journal": "Nucleic acids research",
        "date": "1999",
        "authors": "Yoo S, Dynan WS",
        "reference": {
            "type": "PubMed",
            "id": "10572166",
            "url": "https://pubmed.ncbi.nlm.nih.gov/10572166"
        },
        "referenced_glycans": [],
        "referenced_proteins": [
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                "uniprot_canonical_ac": "Q92993-1",
                "protein_name": "Histone acetyltransferase KAT5",
                "gene_name": "KAT5",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P12956-1",
                "protein_name": "DNA repair protein Ku70",
                "gene_name": "XRCC6",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "Q6ZW49-6",
                "protein_name": "PAX-interacting protein 1",
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                "tax_name": "Human"
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                "protein_name": "Mediator of DNA damage checkpoint protein 1",
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                "uniprot_canonical_ac": "Q9UGP5-1",
                "protein_name": "DNA polymerase lambda",
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                "uniprot_canonical_ac": "Q9NP87-1",
                "protein_name": "DNA-directed DNA/RNA polymerase mu",
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                "uniprot_canonical_ac": "Q5UIP0-1",
                "protein_name": "Telomere-associated protein RIF1",
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            },
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                "uniprot_canonical_ac": "O95551-1",
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                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "Q6UWZ7-1",
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                "tax_name": "Human"
            },
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                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q13426-1",
                "protein_name": "DNA repair protein XRCC4",
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                "tax_name": "Human"
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                "uniprot_canonical_ac": "P49917-1",
                "protein_name": "DNA ligase 4",
                "gene_name": "LIG4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P13010-1",
                "protein_name": "DNA repair protein Ku80",
                "gene_name": "XRCC5",
                "tax_name": "Human"
            },
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                "tax_name": "Human"
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                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O96028-1",
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                "tax_name": "Human"
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                "tax_name": "Human"
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                "uniprot_canonical_ac": "P49959-1",
                "protein_name": "Double-strand break repair protein MRE11",
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                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P23527-1",
                "protein_name": "Histone H2B type 1-O",
                "gene_name": "H2BC17",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8IYW5-1",
                "protein_name": "E3 ubiquitin-protein ligase RNF168",
                "gene_name": "RNF168",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8N2W9-1",
                "protein_name": "E3 SUMO-protein ligase PIAS4",
                "gene_name": "PIAS4",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "O60814-1",
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                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "Q93079-1",
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                "tax_name": "Human"
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                "uniprot_canonical_ac": "Q99879-1",
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                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "Q15819-1",
                "protein_name": "Ubiquitin-conjugating enzyme E2 variant 2",
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                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q92878-1",
                "protein_name": "DNA repair protein RAD50",
                "gene_name": "RAD50",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q96SD1-1",
                "protein_name": "Protein artemis",
                "gene_name": "DCLRE1C",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "Q9H9Q4-1",
                "protein_name": "Non-homologous end-joining factor 1",
                "gene_name": "NHEJ1",
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                "uniprot_canonical_ac": "O95714-1",
                "protein_name": "E3 ubiquitin-protein ligase HERC2",
                "gene_name": "HERC2",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P06899-1",
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                "uniprot_canonical_ac": "P57053-1",
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                "gene_name": "H2BC12L",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "Q8N257-1",
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                "tax_name": "Human"
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                "uniprot_canonical_ac": "Q99877-1",
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                "uniprot_canonical_ac": "P38398-1",
                "protein_name": "Breast cancer type 1 susceptibility protein",
                "gene_name": "BRCA1",
                "tax_name": "Human"
            },
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                "protein_name": "Serine-protein kinase ATM",
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        ],
        "species": [
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                "name": "Homo sapiens",
                "taxid": 9606,
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        ],
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        "abstract": "",
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    {
        "title": "hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response.",
        "journal": "Nature",
        "date": "2000",
        "authors": "Lee JS, Collins KM, Brown AL, Lee CH, Chung JH",
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                "uniprot_canonical_ac": "P46736-1",
                "protein_name": "Lys-63-specific deubiquitinase BRCC36",
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        "title": "Ku recruits the XRCC4-ligase IV complex to DNA ends.",
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        "title": "Role for ATM in DNA damage-induced phosphorylation of BRCA1.",
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        "title": "Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.",
        "journal": "Proceedings of the National Academy of Sciences of the United States of America",
        "date": "2000",
        "authors": "Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ",
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        "title": "Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.",
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            {
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                "end_pos": 1239,
                "sequence_org": "S",
                "sequence_mut": "A",
                "comment": "No effect on in vitro phosphorylation by ATR.",
                "evidence": [
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                        "database": "UniProtKB",
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                "uniprot_canonical_ac": "P38398-1"
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                "sequence_org": "S",
                "sequence_mut": "A",
                "comment": "No effect on in vitro phosphorylation by ATR.",
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                    {
                        "database": "UniProtKB",
                        "id": "P38398",
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                    {
                        "database": "PubMed",
                        "id": "11114888",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11114888"
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                "uniprot_canonical_ac": "P38398-1"
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            {
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                "sequence_org": "S",
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                "comment": "No effect on in vitro phosphorylation by ATR.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P38398",
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                    {
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                "sequence_org": "S",
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                "comment": "Loss of IR-induced S-phase checkpoint. Reduces in vitro phosphorylation by ATR.",
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                        "database": "PubMed",
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                "uniprot_canonical_ac": "P38398-1"
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                        "database": "PubMed",
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                        "database": "UniProtKB",
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        "title": "ATM phosphorylates histone H2AX in response to DNA double-strand breaks.",
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        "title": "Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.",
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    {
        "title": "Histone H2A variants H2AX and H2AZ.",
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        "authors": "Redon C, Pilch D, Rogakou E, Sedelnikova O, Newrock K, Bonner W",
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        "title": "Genomic instability in mice lacking histone H2AX.",
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        "authors": "Celeste A, Petersen S, Romanienko PJ, Fernandez-Capetillo O, Chen HT, Sedelnikova OA, Reina-San-Martin B, Coppola V, Meffre E, Difilippantonio MJ, Redon C, Pilch DR, Olaru A, Eckhaus M, Camerini-Otero RD, Tessarollo L, Livak F, Manova K, Bonner WM, Nussenzweig MC, Nussenzweig A",
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        "title": "Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1.",
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        "title": "Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair.",
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        "authors": "Mahajan KN, Nick McElhinny SA, Mitchell BS, Ramsden DA",
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        "title": "Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase.",
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        "date": "2002",
        "authors": "Douglas P, Sapkota GP, Morrice N, Yu Y, Goodarzi AA, Merkle D, Meek K, Alessi DR, Lees-Miller SP",
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        "title": "DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.",
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                    "kinase_uniprot_canonical_ac",
                    "kinase_gene_name",
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                    "site_lbl",
                    "uniprot_canonical_ac"
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                    {
                        "field": "n_linked_glycan_sites",
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                    {
                        "field": "o_linked_glycan_sites",
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                    {
                        "field": "n_linked_glycans",
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                    {
                        "field": "o_linked_glycans",
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                ],
                "sort_fields": []
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            {
                "table_id": "glycosylation_reported_with_glycan",
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                        "field": "o_linked_glycan_sites",
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                        "field": "n_linked_glycans",
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                    {
                        "field": "o_linked_glycans",
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                ],
                "sort_fields": []
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            {
                "table_id": "glycosylation_automatic_literature_mining",
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                        "field": "n_linked_glycan_sites",
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                        "field": "o_linked_glycan_sites",
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                        "field": "n_linked_glycans",
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                    {
                        "field": "o_linked_glycans",
                        "count": 0
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                ],
                "sort_fields": []
            }
        ]
    },
    {
        "title": "Tip60 acetyltransferase activity is controlled by phosphorylation.",
        "journal": "The Journal of biological chemistry",
        "date": "2003",
        "authors": "Lemercier C, Legube G, Caron C, Louwagie M, Garin J, Trouche D, Khochbin S",
        "reference": {
            "type": "PubMed",
            "id": "12468530",
            "url": "https://pubmed.ncbi.nlm.nih.gov/12468530"
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        "referenced_glycans": [],
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                "uniprot_canonical_ac": "Q92993-1",
                "protein_name": "Histone acetyltransferase KAT5",
                "gene_name": "KAT5",
                "tax_name": "Human"
            }
        ],
        "species": [
            {
                "name": "Homo sapiens",
                "taxid": 9606,
                "evidence": [
                    {
                        "database": "UniProtKB",
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                ],
                "common_name": "Human",
                "glygen_name": "Human",
                "reference_species": "Homo sapiens [9606]"
            }
        ],
        "mutagenesis": [
            {
                "start_pos": 254,
                "end_pos": 254,
                "sequence_org": "L",
                "sequence_mut": "A",
                "comment": "Does not affect phosphorylation; when associated with A-257.",
                "evidence": [
                    {
                        "database": "UniProtKB",
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                        "url": "https://www.uniprot.org/uniprotkb/Q92993"
                    },
                    {
                        "database": "PubMed",
                        "id": "12468530",
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                ],
                "uniprot_canonical_ac": "Q92993-1"
            },
            {
                "start_pos": 257,
                "end_pos": 257,
                "sequence_org": "L",
                "sequence_mut": "A",
                "comment": "Does not affect phosphorylation; when associated with A-254.",
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                    {
                        "database": "UniProtKB",
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                    {
                        "database": "PubMed",
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                ],
                "uniprot_canonical_ac": "Q92993-1"
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            {
                "start_pos": 380,
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                "sequence_org": "G",
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                "comment": "Loss of function. Does not affect phosphorylation.",
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                    {
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                ],
                "uniprot_canonical_ac": "Q92993-1"
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            {
                "start_pos": 86,
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                "sequence_org": "S",
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                "comment": "Reduced phosphorylation. Abolishes phosphorylation; when associated with A-90. Reduced histone acetyltransferase activity. Abolished phosphorylation by GSK3 and decreased acetyltransferase activity.",
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                "uniprot_canonical_ac": "Q92993-1"
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            {
                "start_pos": 90,
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                "comment": "Reduced phosphorylation, leading to reduced protein acetyltransferase activity. Abolishes phosphorylation; when associated with A-86. Reduced histone acetyltransferase activity. Abolished phosphorylation by GSK3 at S-86.",
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                        "url": "https://pubmed.ncbi.nlm.nih.gov/12468530"
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                "start_pos": 86,
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                "start_pos": 86,
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                "uniprot_canonical_ac": "Q92993-1"
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            {
                "start_pos": 86,
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                        "database": "PubMed",
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                ],
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                "uniprot_canonical_ac": "Q92993-1"
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            {
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                "start_pos": 90,
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                "kinase_uniprot_canonical_ac": "",
                "kinase_gene_name": "",
                "residue": "Ser",
                "comment": "Phosphoserine; by CDK1 and CDK9",
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    {
        "title": "Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains.",
        "journal": "The EMBO journal",
        "date": "2002",
        "authors": "Mallery DL, Vandenberg CJ, Hiom K",
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            {
                "uniprot_canonical_ac": "Q92560-1",
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            {
                "uniprot_canonical_ac": "O76064-1",
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            {
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        "title": "Defining interactions between DNA-PK and ligase IV/XRCC4.",
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    {
        "title": "The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin.",
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        "authors": "Wu-Baer F, Lagrazon K, Yuan W, Baer R",
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        "title": "BARD1 participates with BRCA1 in homology-directed repair of chromosome breaks.",
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        "title": "HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses.",
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        "title": "XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining.",
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                "uniprot_canonical_ac": "P62807-1",
                "protein_name": "Histone H2B type 1-C/E/F/G/I",
                "gene_name": "H2BC10; H2BC4; H2BC6; H2BC7; H2BC8",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O96028-1",
                "protein_name": "Histone-lysine N-methyltransferase NSD2",
                "gene_name": "NSD2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P63165-1",
                "protein_name": "Small ubiquitin-related modifier 1",
                "gene_name": "SUMO1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P49959-1",
                "protein_name": "Double-strand break repair protein MRE11",
                "gene_name": "MRE11",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O00167-1",
                "protein_name": "Protein phosphatase EYA2",
                "gene_name": "EYA2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q99504-1",
                "protein_name": "Protein phosphatase EYA3",
                "gene_name": "EYA3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P45983-1",
                "protein_name": "Mitogen-activated protein kinase 8",
                "gene_name": "MAPK8",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O60264-1",
                "protein_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5",
                "gene_name": "SMARCA5",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q99728-1",
                "protein_name": "BRCA1-associated RING domain protein 1",
                "gene_name": "BARD1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9NWV8-1",
                "protein_name": "BRISC and BRCA1-A complex member 1",
                "gene_name": "BABAM1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P62979-1",
                "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein",
                "gene_name": "RPS27A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9NXR7-2",
                "protein_name": "BRISC and BRCA1-A complex member 2",
                "gene_name": "BABAM2",
                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "Q9UIG0-1",
                "protein_name": "Tyrosine-protein kinase BAZ1B",
                "gene_name": "BAZ1B",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P16104-1",
                "protein_name": "Histone H2AX",
                "gene_name": "H2AX",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P61088-1",
                "protein_name": "Ubiquitin-conjugating enzyme E2 N",
                "gene_name": "UBE2N",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P33778-1",
                "protein_name": "Histone H2B type 1-B",
                "gene_name": "H2BC3",
                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "P58876-1",
                "protein_name": "Histone H2B type 1-D",
                "gene_name": "H2BC5",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q96A08-1",
                "protein_name": "Histone H2B type 1-A",
                "gene_name": "H2BC1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P23527-1",
                "protein_name": "Histone H2B type 1-O",
                "gene_name": "H2BC17",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O75164-1",
                "protein_name": "Lysine-specific demethylase 4A",
                "gene_name": "KDM4A",
                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "Q8IYW5-1",
                "protein_name": "E3 ubiquitin-protein ligase RNF168",
                "gene_name": "RNF168",
                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "Q8N2W9-1",
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                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "O60814-1",
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                "gene_name": "H2BC12",
                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "Q93079-1",
                "protein_name": "Histone H2B type 1-H",
                "gene_name": "H2BC9",
                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "Q99879-1",
                "protein_name": "Histone H2B type 1-M",
                "gene_name": "H2BC14",
                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "Q15819-1",
                "protein_name": "Ubiquitin-conjugating enzyme E2 variant 2",
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                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "Q92878-1",
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                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "P0CG47-1",
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                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "P62987-1",
                "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein",
                "gene_name": "UBA52",
                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "O95677-1",
                "protein_name": "Protein phosphatase EYA4",
                "gene_name": "EYA4",
                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "Q99502-1",
                "protein_name": "Protein phosphatase EYA1",
                "gene_name": "EYA1",
                "tax_name": "Human"
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            {
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                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "P06899-1",
                "protein_name": "Histone H2B type 1-J",
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                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "P57053-1",
                "protein_name": "Histone H2B type F-S",
                "gene_name": "H2BC12L",
                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "Q8N257-1",
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                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "Q99877-1",
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                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "Q99880-1",
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                "tax_name": "Human"
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            {
                "uniprot_canonical_ac": "O00213-1",
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            {
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            {
                "uniprot_canonical_ac": "O96017-1",
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                "comment": "Impairs localization to DNA damages sites; when associated with S-88; S-113 and A-117.",
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                "uniprot_canonical_ac": "Q96RL1-1"
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                "start_pos": 406,
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        "title": "The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter.",
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    {
        "title": "RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.",
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        "title": "NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway.",
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    {
        "title": "BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity.",
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        "date": "2009",
        "authors": "Nishikawa H, Wu W, Koike A, Kojima R, Gomi H, Fukuda M, Ohta T",
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