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Complete loss of palmitoylation, no effect on endocytosis, recycling inhibited and AP1S1 binding reduced by 30%; when associated with C-1186. Accumulates in intracellular compartments; when associated with C-1186 and N-1203.", "evidence": [ { "database": "UniProtKB", "id": "P15941", "url": "https://www.uniprot.org/uniprotkb/P15941" }, { "database": "PubMed", "id": "16507569", "url": "https://pubmed.ncbi.nlm.nih.gov/16507569" } ], "uniprot_canonical_ac": "P15941-1" }, { "start_pos": 1186, "end_pos": 1186, "sequence_org": "C", "sequence_mut": "A", "comment": "S-palmitoylation reduced by 50%. Complete loss of palmitoylation, no effect on endocytosis, recycling inhibited, and AP1S1 binding reduced by 30%; when associated with C-1184. Accumulates in intracellular compartments; when associated with C-1184 and N-1203.", "evidence": [ { "database": "UniProtKB", "id": "P15941", "url": "https://www.uniprot.org/uniprotkb/P15941" }, { "database": "PubMed", "id": "16507569", "url": "https://pubmed.ncbi.nlm.nih.gov/16507569" } ], "uniprot_canonical_ac": "P15941-1" }, { "start_pos": 1187, "end_pos": 1189, "sequence_org": "RRK", "sequence_mut": "AAA", "comment": "No nuclear targeting of HRG-stimulated MUC1 C-terminal nor JUP/gamma-catenin. 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No effect on in vitro PDFGR-induced cell invasiveness.", "evidence": [ { "database": "UniProtKB", "id": "P15941", "url": "https://www.uniprot.org/uniprotkb/P15941" }, { "database": "PubMed", "id": "16507569", "url": "https://pubmed.ncbi.nlm.nih.gov/16507569" }, { "database": "PubMed", "id": "15471854", "url": "https://pubmed.ncbi.nlm.nih.gov/15471854" }, { "database": "PubMed", "id": "17545600", "url": "https://pubmed.ncbi.nlm.nih.gov/17545600" }, { "database": "PubMed", "id": "11483589", "url": "https://pubmed.ncbi.nlm.nih.gov/11483589" } ], "uniprot_canonical_ac": "P15941-1" }, { "start_pos": 1203, "end_pos": 1203, "sequence_org": "Y", "sequence_mut": "F", "comment": "No effect on EGFR-mediated phosphorylation. No nuclear localization of MUC1CT. Reduced in vitro PDGFR-induced cell invasiveness.", "evidence": [ { "database": "UniProtKB", "id": "P15941", "url": "https://www.uniprot.org/uniprotkb/P15941" }, { "database": "PubMed", "id": "16507569", "url": "https://pubmed.ncbi.nlm.nih.gov/16507569" }, { "database": "PubMed", "id": "15471854", "url": "https://pubmed.ncbi.nlm.nih.gov/15471854" }, { "database": "PubMed", "id": "17545600", "url": "https://pubmed.ncbi.nlm.nih.gov/17545600" }, { "database": "PubMed", "id": "11483589", "url": "https://pubmed.ncbi.nlm.nih.gov/11483589" } ], "uniprot_canonical_ac": "P15941-1" }, { "start_pos": 1203, "end_pos": 1203, "sequence_org": "Y", "sequence_mut": "N", "comment": "Reduced endocytosis by 30%. Greatly reduced binding to AP1S2 and GRB2. Binding AP1S1 reduced by 25%. Reduced endocytosis by 77%; when associated with N-1243. Accumulates in intracellular compartments; when associated with C-1184 and C-1186.", "evidence": [ { "database": "UniProtKB", "id": "P15941", "url": "https://www.uniprot.org/uniprotkb/P15941" }, { "database": "PubMed", "id": "16507569", "url": "https://pubmed.ncbi.nlm.nih.gov/16507569" }, { "database": "PubMed", "id": "15471854", "url": "https://pubmed.ncbi.nlm.nih.gov/15471854" }, { "database": "PubMed", "id": "17545600", "url": "https://pubmed.ncbi.nlm.nih.gov/17545600" }, { "database": "PubMed", "id": "11483589", "url": "https://pubmed.ncbi.nlm.nih.gov/11483589" } ], "uniprot_canonical_ac": "P15941-1" } ], "record_id": "pubmed.16507569", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "N-glycosylation of the MUC1 mucin in epithelial cells and secretions.", "journal": "Glycobiology", "date": "2006", "authors": "Parry Simon, Hanisch Franz Georg, Leir Shih-Hsing, Sutton-Smith Mark, Morris Howard R, Dell Anne, Harris Ann", "reference": { "type": "PubMed", "id": "16585136", "url": "https://pubmed.ncbi.nlm.nih.gov/16585136" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P15941-1", "protein_name": "Mucin-1", "gene_name": "MUC1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": 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characterization of an expressed hypervariable gene coding for a breast-cancer-associated antigen.", "journal": "Gene", "date": "1990", "authors": "Tsarfaty I, Hareuveni M, Horev J, Zaretsky J, Weiss M, Jeltsch JM, Garnier JM, Lathe R, Keydar I, Wreschner DH", "reference": { "type": "PubMed", "id": "1688329", "url": "https://pubmed.ncbi.nlm.nih.gov/1688329" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P15941-1", "protein_name": "Mucin-1", "gene_name": "MUC1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P15941", "url": "https://www.uniprot.org/uniprotkb/P15941" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.1688329", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { 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Biol. Chem.", "date": "1990", "authors": "Gendler S J, Lancaster C A, Taylor-Papadimitriou J, Duhig T, Peat N, Burchell J, Pemberton L, Lalani E N, Wilson D", "reference": { "type": "PubMed", "id": "1697589", "url": "https://pubmed.ncbi.nlm.nih.gov/1697589" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P15941-1", "protein_name": "Mucin-1", "gene_name": "MUC1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P15941", "url": "https://www.uniprot.org/uniprotkb/P15941" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.1697589", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", 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{ "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "MUC1 is a novel regulator of ErbB1 receptor trafficking.", "journal": "Oncogene", "date": "2007", "authors": "Pochampalli M R, el Bejjani R M, Schroeder J A", "reference": { "type": "PubMed", "id": "16983337", "url": "https://pubmed.ncbi.nlm.nih.gov/16983337" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P15941-1", "protein_name": "Mucin-1", "gene_name": "MUC1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P15941", 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"o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Enhanced major histocompatibility complex class I binding and immune responses through anchor modification of the non-canonical tumour-associated mucin 1-8 peptide.", "journal": "Immunology", "date": "2006-11", "authors": "Lazoura Eliada, Lodding Jodie, Farrugia William, Ramsland Paul A, Stevens James, Wilson Ian A, Pietersz Geoffrey A, Apostolopoulos Vasso", "reference": { "type": "PubMed", "id": "17067310", "url": "https://pubmed.ncbi.nlm.nih.gov/17067310" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P15941-1", "protein_name": "Mucin-1", "gene_name": "MUC1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P15941", "url": "https://www.uniprot.org/uniprotkb/P15941" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.17067310", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ 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Chim. Acta", "date": "2010", "authors": "Duffy Michael J, Evoy Denis, McDermott Enda W", "reference": { "type": "PubMed", "id": "20816948", "url": "https://pubmed.ncbi.nlm.nih.gov/20816948" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P15941-1", "protein_name": "Mucin-1", "gene_name": "MUC1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P15941", "url": "https://www.uniprot.org/uniprotkb/P15941" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "biomarkers": [ { "best_biomarker_role": [ "monitoring", "prognostic" ], "biomarker_canonical_id": "AN6324", "assessed_biomarker_entity": [ "Mucin-1" ], "biomarker_id": "AN6324-1", "biomarker": [ "increased levels of Mucin-1" ], "condition": { "id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "https://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "An organ system cancer that originates in the mammary gland." }, "name_list": [ "breast cancer", "breast tumor", "malignant neoplasm of breast", "malignant tumor of the breast", "mammary cancer", "mammary tumor", "primary breast cancer", "hereditary breast carcinoma", "breast cancer susceptibility, autosomal dominant, somatic mutation", "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "breast cancer, lobular, somatic", "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "breast cancer, protection against, autosomal dominant, somatic mutation", "breast cancer, somatic", "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "familial breast cancer", "familial breast carcinoma", "familial cancer of breast", "familial cancer of the breast", "hereditary breast cancer", "Breast cancer" ], 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Cell Sci.", "date": "2001", "authors": "Landsverk H B, Carlson C R, Steen R L, Vossebein L, Herberg F W, Task\u00e9n K, Collas P", "reference": { "type": "PubMed", "id": "11591814", "url": "https://pubmed.ncbi.nlm.nih.gov/11591814" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43823-1", "protein_name": "A-kinase anchor protein 8", "gene_name": "AKAP8", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43823", "url": "https://www.uniprot.org/uniprotkb/O43823" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11591814", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", 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{ "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein.", "journal": "FEBS letters", "date": "2004", "authors": "Choi W, Zibaee S, Jakes R, Serpell LC, Davletov B, Crowther RA, Goedert M", "reference": { "type": "PubMed", "id": "15498564", "url": "https://pubmed.ncbi.nlm.nih.gov/15498564" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P37840-1", "protein_name": "Alpha-synuclein", "gene_name": "SNCA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P37840", "url": "https://www.uniprot.org/uniprotkb/P37840" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.15498564", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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