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[], "referenced_proteins": [ { "uniprot_canonical_ac": "P06400-1", "protein_name": "Retinoblastoma-associated protein", "gene_name": "RB1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P06400", "url": "https://www.uniprot.org/uniprotkb/P06400" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "phosphorylation": [ { "start_pos": 805, "end_pos": 805, "kinase_uniprot_canonical_ac": "P00519-1", "kinase_gene_name": "ABL1", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P06400", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06400" }, { "database": "PubMed", "id": "16158058", "url": "https://pubmed.ncbi.nlm.nih.gov/16158058" } ], "site_lbl": "Tyr805", "uniprot_canonical_ac": "P06400-1" } ], "record_id": "pubmed.16158058", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], 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"Kardinal C, Dangers M, Kardinal A, Koch A, Brandt DT, Tamura T, Welte K", "reference": { "type": "PubMed", "id": "16195327", "url": "https://pubmed.ncbi.nlm.nih.gov/16195327" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P06400-1", "protein_name": "Retinoblastoma-associated protein", "gene_name": "RB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01094-1", "protein_name": "Transcription factor E2F1", "gene_name": "E2F1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61024-1", "protein_name": "Cyclin-dependent kinases regulatory subunit 1", "gene_name": "CKS1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13616-1", "protein_name": "Cullin-1", "gene_name": "CUL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60674-1", "protein_name": "Tyrosine-protein kinase JAK2", "gene_name": "JAK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13309-1", "protein_name": "S-phase kinase-associated protein 2", "gene_name": "SKP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62714-1", "protein_name": "Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform", "gene_name": "PPP2CB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42771-1", "protein_name": "Cyclin-dependent kinase inhibitor 2A", "gene_name": "CDKN2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42772-1", "protein_name": "Cyclin-dependent kinase 4 inhibitor B", "gene_name": "CDKN2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30281-1", "protein_name": "G1/S-specific cyclin-D3", "gene_name": "CCND3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5P8-1", "protein_name": "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta", "gene_name": "PPP2R3B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08999-1", "protein_name": "Retinoblastoma-like protein 2", "gene_name": "RBL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P51948-1", "protein_name": "CDK-activating kinase assembly 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"uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14186-1", "protein_name": "Transcription factor Dp-1", "gene_name": "TFDP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00716-1", "protein_name": "Transcription factor E2F3", "gene_name": "E2F3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14209-1", "protein_name": "Transcription factor E2F2", "gene_name": "E2F2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13882-1", "protein_name": "Protein-tyrosine kinase 6", "gene_name": "PTK6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00519-1", "protein_name": "Tyrosine-protein kinase ABL1", "gene_name": "ABL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63208-1", "protein_name": "S-phase kinase-associated protein 1", "gene_name": "SKP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30154-1", "protein_name": "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform", "gene_name": "PPP2R1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30153-1", "protein_name": "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "gene_name": "PPP2R1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P67775-1", "protein_name": "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform", "gene_name": "PPP2CA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P06400", "url": "https://www.uniprot.org/uniprotkb/P06400" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 74, "end_pos": 74, "sequence_org": "Y", "sequence_mut": "F", "comment": "No change in binding CDK4 and no inhibition of CDK4 activity. Translocates to nucleus. No effect on in vitro phosphorylation of CDK4 by CCNH-CDK7.", "evidence": [ { "database": "UniProtKB", "id": "P46527", "url": "https://www.uniprot.org/uniprotkb/P46527" }, { "database": "PubMed", "id": "16195327", "url": "https://pubmed.ncbi.nlm.nih.gov/16195327" }, { "database": "PubMed", "id": "19075005", "url": "https://pubmed.ncbi.nlm.nih.gov/19075005" } ], "uniprot_canonical_ac": "P46527-1" }, { "start_pos": 88, "end_pos": 88, "sequence_org": "Y", "sequence_mut": "F", "comment": "Abolishes LYN-mediated phosphorylation, reduces CDK2-mediated phosphorylation on T-187, has greater cell cycle arrest into S-phase, no effect on binding CDK2 complexes, reduced CDK4 binding and inhibits CDK4 enzyme activity. No nuclear translocation. No effect on in vitro phosphorylation of CDK4 by CCNH-CDK7. Completely abolishes CDK4 binding; when associated with F-89.", "evidence": [ { "database": "UniProtKB", "id": "P46527", "url": "https://www.uniprot.org/uniprotkb/P46527" }, { "database": "PubMed", "id": "16195327", "url": "https://pubmed.ncbi.nlm.nih.gov/16195327" }, { "database": "PubMed", "id": "17254966", "url": "https://pubmed.ncbi.nlm.nih.gov/17254966" }, { "database": "PubMed", "id": "19075005", "url": "https://pubmed.ncbi.nlm.nih.gov/19075005" } ], "uniprot_canonical_ac": "P46527-1" }, { "start_pos": 89, "end_pos": 89, "sequence_org": "Y", "sequence_mut": "F", "comment": "No effect on binding CDK2 complexes, reduced CDK4 binding and greatly inhibits CDK4 enzyme activity. No nuclear translocation. Inhibits in vitro phosphorylation of CDK4 by CCNH-CDK7. Completely abolishes CDK4 binding; when associated with F-88.", "evidence": [ { "database": "UniProtKB", "id": "P46527", "url": "https://www.uniprot.org/uniprotkb/P46527" }, { "database": "PubMed", "id": "16195327", "url": "https://pubmed.ncbi.nlm.nih.gov/16195327" }, { "database": "PubMed", "id": "17254966", "url": "https://pubmed.ncbi.nlm.nih.gov/17254966" }, { "database": "PubMed", "id": "19075005", "url": "https://pubmed.ncbi.nlm.nih.gov/19075005" } ], "uniprot_canonical_ac": "P46527-1" } ], "phosphorylation": [ { "start_pos": 88, "end_pos": 88, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine; by ABL, LYN, SRC and JAK2", "evidence": [ { "database": "UniProtKB", "id": "P46527", "url": "https://www.uniprot.org/uniprotkb/P46527" }, { "database": "PRO", "id": "P46527", "url": "https://proconsortium.org/cgi-bin/entry_pro?id=P46527" }, { "database": "iPTMnet", "id": "P46527", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P46527" }, { "database": "PubMed", "id": "17254966", "url": "https://pubmed.ncbi.nlm.nih.gov/17254966" }, { "database": "PubMed", "id": "16195327", "url": "https://pubmed.ncbi.nlm.nih.gov/16195327" }, { "database": "PubMed", "id": "29330290", "url": "https://pubmed.ncbi.nlm.nih.gov/29330290" }, { "database": "PubMed", "id": "33147476", "url": "https://pubmed.ncbi.nlm.nih.gov/33147476" }, { "database": "PubMed", "id": "35597806", "url": "https://pubmed.ncbi.nlm.nih.gov/35597806" }, { "database": "PubMed", "id": "17254967", "url": "https://pubmed.ncbi.nlm.nih.gov/17254967" }, { "database": "PubMed", "id": "21423214", "url": "https://pubmed.ncbi.nlm.nih.gov/21423214" } ], "site_lbl": "Tyr88", "uniprot_canonical_ac": "P46527-1" }, { "start_pos": 89, "end_pos": 89, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "P46527", "url": 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}, { "title": "p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2.", "journal": "Cell", "date": "2007", "authors": "Chu I, Sun J, Arnaout A, Kahn H, Hanna W, Narod S, Sun P, Tan CK, Hengst L, Slingerland J", "reference": { "type": "PubMed", "id": "17254967", "url": "https://pubmed.ncbi.nlm.nih.gov/17254967" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P06400-1", "protein_name": "Retinoblastoma-associated protein", "gene_name": "RB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01094-1", "protein_name": "Transcription factor E2F1", "gene_name": "E2F1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61024-1", "protein_name": "Cyclin-dependent kinases regulatory subunit 1", "gene_name": "CKS1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13616-1", "protein_name": "Cullin-1", "gene_name": "CUL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60674-1", "protein_name": "Tyrosine-protein kinase JAK2", "gene_name": 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"protein_name": "Histone H2A type 1-D", "gene_name": "H2AC7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P57053-1", "protein_name": "Histone H2B type F-S", "gene_name": "H2BC12L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16777-1", "protein_name": "Histone H2A type 2-C", "gene_name": "H2AC20", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6FI13-1", "protein_name": "Histone H2A type 2-A", "gene_name": "H2AC18; H2AC19", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N257-1", "protein_name": "Histone H2B type 3-B", "gene_name": "H2BC26", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99877-1", "protein_name": "Histone H2B type 1-N", "gene_name": "H2BC15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99878-1", "protein_name": "Histone H2A type 1-J", "gene_name": "H2AC14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99880-1", "protein_name": "Histone H2B type 1-L", "gene_name": "H2BC13", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P06400", "url": "https://www.uniprot.org/uniprotkb/P06400" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.18211953", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 41 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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[] } ] }, { "title": "Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1991", "authors": "Templeton DJ, Park SH, Lanier L, Weinberg RA", "reference": { "type": "PubMed", "id": "1826560", "url": "https://pubmed.ncbi.nlm.nih.gov/1826560" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P06400-1", "protein_name": "Retinoblastoma-associated protein", "gene_name": "RB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01094-1", "protein_name": "Transcription factor E2F1", "gene_name": "E2F1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30281-1", "protein_name": "G1/S-specific cyclin-D3", "gene_name": "CCND3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24385-1", "protein_name": "G1/S-specific cyclin-D1", "gene_name": "CCND1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46527-1", "protein_name": "Cyclin-dependent kinase inhibitor 1B", "gene_name": "CDKN1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24864-1", "protein_name": "G1/S-specific cyclin-E1", "gene_name": "CCNE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14188-1", "protein_name": "Transcription factor Dp-2", "gene_name": "TFDP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P11802-1", "protein_name": "Cyclin-dependent kinase 4", "gene_name": "CDK4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30279-1", "protein_name": "G1/S-specific cyclin-D2", "gene_name": "CCND2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38936-1", "protein_name": "Cyclin-dependent kinase inhibitor 1", "gene_name": "CDKN1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24941-1", "protein_name": "Cyclin-dependent kinase 2", "gene_name": "CDK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49918-1", "protein_name": "Cyclin-dependent kinase inhibitor 1C", "gene_name": "CDKN1C", "tax_name": "Human" }, { "uniprot_canonical_ac": "O96020-1", "protein_name": "G1/S-specific cyclin-E2", "gene_name": "CCNE2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00534-1", "protein_name": "Cyclin-dependent kinase 6", "gene_name": "CDK6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14186-1", "protein_name": "Transcription factor Dp-1", "gene_name": "TFDP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00716-1", "protein_name": "Transcription factor E2F3", "gene_name": "E2F3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14209-1", "protein_name": "Transcription factor E2F2", "gene_name": "E2F2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P06400", "url": "https://www.uniprot.org/uniprotkb/P06400" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.1826560", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 17 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The E2F transcription factor is a cellular target for the RB protein.", "journal": "Cell", "date": "1991", "authors": "Chellappan SP, Hiebert S, Mudryj M, Horowitz JM, Nevins JR", "reference": { "type": "PubMed", "id": "1828392", "url": "https://pubmed.ncbi.nlm.nih.gov/1828392" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P06400-1", "protein_name": "Retinoblastoma-associated protein", "gene_name": "RB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01094-1", "protein_name": "Transcription factor E2F1", "gene_name": "E2F1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61024-1", "protein_name": "Cyclin-dependent kinases regulatory subunit 1", "gene_name": "CKS1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13616-1", "protein_name": "Cullin-1", "gene_name": "CUL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60674-1", "protein_name": "Tyrosine-protein kinase JAK2", "gene_name": "JAK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13309-1", "protein_name": "S-phase kinase-associated protein 2", "gene_name": "SKP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62714-1", "protein_name": "Serine/threonine-protein phosphatase 2A catalytic 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"gene_name": "CCNH", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63151-1", "protein_name": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "gene_name": "PPP2R2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07948-1", "protein_name": "Tyrosine-protein kinase Lyn", "gene_name": "LYN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24385-1", "protein_name": "G1/S-specific cyclin-D1", "gene_name": "CCND1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46527-1", "protein_name": "Cyclin-dependent kinase inhibitor 1B", "gene_name": "CDKN1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55273-1", "protein_name": "Cyclin-dependent kinase 4 inhibitor D", "gene_name": "CDKN2D", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24864-1", "protein_name": "G1/S-specific cyclin-E1", "gene_name": "CCNE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14188-1", "protein_name": "Transcription factor Dp-2", "gene_name": "TFDP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15329-1", "protein_name": "Transcription factor E2F5", "gene_name": "E2F5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16254-1", "protein_name": "Transcription factor E2F4", "gene_name": "E2F4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P28749-1", "protein_name": "Retinoblastoma-like protein 1", "gene_name": "RBL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P11802-1", "protein_name": "Cyclin-dependent kinase 4", "gene_name": "CDK4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30279-1", "protein_name": "G1/S-specific cyclin-D2", "gene_name": "CCND2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38936-1", "protein_name": "Cyclin-dependent kinase inhibitor 1", "gene_name": "CDKN1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P50613-1", "protein_name": "Cyclin-dependent kinase 7", "gene_name": "CDK7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24941-1", "protein_name": "Cyclin-dependent kinase 2", "gene_name": "CDK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49918-1", "protein_name": "Cyclin-dependent kinase inhibitor 1C", "gene_name": "CDKN1C", "tax_name": "Human" }, { "uniprot_canonical_ac": "O96020-1", "protein_name": "G1/S-specific cyclin-E2", "gene_name": "CCNE2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00534-1", "protein_name": "Cyclin-dependent kinase 6", "gene_name": "CDK6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42773-1", "protein_name": "Cyclin-dependent kinase 4 inhibitor C", "gene_name": "CDKN2C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", 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"o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F.", "journal": "Cell", "date": "1991", "authors": "Bagchi S, Weinmann R, Raychaudhuri P", "reference": { "type": "PubMed", "id": "1828393", "url": "https://pubmed.ncbi.nlm.nih.gov/1828393" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P06400-1", "protein_name": "Retinoblastoma-associated protein", "gene_name": "RB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01094-1", "protein_name": "Transcription factor E2F1", "gene_name": "E2F1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61024-1", "protein_name": "Cyclin-dependent kinases regulatory subunit 1", "gene_name": "CKS1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13616-1", "protein_name": "Cullin-1", "gene_name": "CUL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60674-1", "protein_name": "Tyrosine-protein kinase JAK2", "gene_name": "JAK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13309-1", "protein_name": "S-phase kinase-associated protein 2", "gene_name": "SKP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62714-1", "protein_name": "Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform", "gene_name": "PPP2CB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42771-1", "protein_name": "Cyclin-dependent kinase inhibitor 2A", "gene_name": "CDKN2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42772-1", "protein_name": "Cyclin-dependent kinase 4 inhibitor B", "gene_name": "CDKN2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30281-1", "protein_name": "G1/S-specific cyclin-D3", "gene_name": "CCND3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5P8-1", "protein_name": "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta", "gene_name": "PPP2R3B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08999-1", "protein_name": "Retinoblastoma-like protein 2", "gene_name": "RBL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P51948-1", "protein_name": "CDK-activating kinase assembly factor MAT1", "gene_name": "MNAT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P51946-1", "protein_name": "Cyclin-H", "gene_name": "CCNH", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63151-1", "protein_name": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "gene_name": "PPP2R2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07948-1", "protein_name": "Tyrosine-protein kinase Lyn", "gene_name": "LYN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24385-1", "protein_name": "G1/S-specific cyclin-D1", "gene_name": "CCND1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46527-1", "protein_name": "Cyclin-dependent kinase inhibitor 1B", "gene_name": "CDKN1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55273-1", "protein_name": "Cyclin-dependent kinase 4 inhibitor D", "gene_name": "CDKN2D", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24864-1", "protein_name": "G1/S-specific cyclin-E1", "gene_name": "CCNE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14188-1", "protein_name": "Transcription factor Dp-2", "gene_name": "TFDP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15329-1", "protein_name": "Transcription factor E2F5", "gene_name": "E2F5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16254-1", "protein_name": "Transcription factor E2F4", "gene_name": "E2F4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P28749-1", "protein_name": "Retinoblastoma-like protein 1", "gene_name": "RBL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P11802-1", "protein_name": "Cyclin-dependent kinase 4", "gene_name": "CDK4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30279-1", "protein_name": "G1/S-specific cyclin-D2", "gene_name": "CCND2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38936-1", "protein_name": "Cyclin-dependent kinase inhibitor 1", "gene_name": "CDKN1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P50613-1", "protein_name": "Cyclin-dependent kinase 7", "gene_name": "CDK7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24941-1", "protein_name": "Cyclin-dependent kinase 2", "gene_name": "CDK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49918-1", "protein_name": "Cyclin-dependent kinase inhibitor 1C", "gene_name": "CDKN1C", "tax_name": "Human" }, { "uniprot_canonical_ac": "O96020-1", "protein_name": "G1/S-specific cyclin-E2", "gene_name": "CCNE2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00534-1", "protein_name": "Cyclin-dependent kinase 6", "gene_name": "CDK6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42773-1", "protein_name": "Cyclin-dependent kinase 4 inhibitor C", "gene_name": "CDKN2C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14186-1", "protein_name": "Transcription factor Dp-1", "gene_name": "TFDP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00716-1", "protein_name": "Transcription factor E2F3", "gene_name": "E2F3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14209-1", "protein_name": "Transcription factor E2F2", "gene_name": "E2F2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13882-1", "protein_name": "Protein-tyrosine kinase 6", "gene_name": "PTK6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00519-1", "protein_name": "Tyrosine-protein kinase ABL1", "gene_name": "ABL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63208-1", "protein_name": "S-phase kinase-associated protein 1", "gene_name": "SKP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30154-1", "protein_name": "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform", "gene_name": "PPP2R1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30153-1", "protein_name": "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "gene_name": "PPP2R1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P67775-1", "protein_name": "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform", "gene_name": "PPP2CA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P06400", "url": "https://www.uniprot.org/uniprotkb/P06400" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.1828393", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 46 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein.", "journal": "Cell", "date": "1991", "authors": "Chittenden T, Livingston DM, Kaelin WG Jr", "reference": { "type": "PubMed", "id": "1828394", "url": "https://pubmed.ncbi.nlm.nih.gov/1828394" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P06400-1", "protein_name": "Retinoblastoma-associated protein", "gene_name": "RB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01094-1", "protein_name": "Transcription factor E2F1", "gene_name": "E2F1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61024-1", "protein_name": "Cyclin-dependent kinases regulatory subunit 1", "gene_name": "CKS1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13616-1", "protein_name": "Cullin-1", "gene_name": "CUL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60674-1", "protein_name": "Tyrosine-protein kinase JAK2", "gene_name": "JAK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13309-1", "protein_name": "S-phase kinase-associated protein 2", "gene_name": "SKP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62714-1", "protein_name": "Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform", "gene_name": "PPP2CB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42771-1", "protein_name": "Cyclin-dependent kinase inhibitor 2A", "gene_name": "CDKN2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42772-1", "protein_name": "Cyclin-dependent kinase 4 inhibitor B", "gene_name": "CDKN2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30281-1", "protein_name": "G1/S-specific cyclin-D3", "gene_name": "CCND3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5P8-1", "protein_name": "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta", "gene_name": "PPP2R3B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08999-1", "protein_name": "Retinoblastoma-like protein 2", "gene_name": "RBL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P51948-1", "protein_name": "CDK-activating kinase assembly factor MAT1", "gene_name": "MNAT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P51946-1", "protein_name": "Cyclin-H", "gene_name": "CCNH", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63151-1", "protein_name": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "gene_name": "PPP2R2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07948-1", "protein_name": "Tyrosine-protein kinase Lyn", "gene_name": "LYN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24385-1", "protein_name": "G1/S-specific cyclin-D1", "gene_name": "CCND1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46527-1", "protein_name": "Cyclin-dependent kinase inhibitor 1B", "gene_name": "CDKN1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55273-1", "protein_name": "Cyclin-dependent kinase 4 inhibitor D", "gene_name": "CDKN2D", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24864-1", "protein_name": "G1/S-specific cyclin-E1", "gene_name": "CCNE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14188-1", "protein_name": "Transcription factor Dp-2", "gene_name": "TFDP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15329-1", "protein_name": "Transcription factor E2F5", "gene_name": "E2F5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16254-1", "protein_name": "Transcription factor E2F4", "gene_name": "E2F4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P28749-1", "protein_name": "Retinoblastoma-like protein 1", "gene_name": "RBL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P11802-1", "protein_name": "Cyclin-dependent kinase 4", "gene_name": "CDK4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30279-1", "protein_name": "G1/S-specific cyclin-D2", "gene_name": "CCND2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38936-1", "protein_name": "Cyclin-dependent kinase inhibitor 1", "gene_name": "CDKN1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P50613-1", "protein_name": "Cyclin-dependent kinase 7", "gene_name": "CDK7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24941-1", "protein_name": "Cyclin-dependent kinase 2", "gene_name": "CDK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49918-1", "protein_name": "Cyclin-dependent kinase inhibitor 1C", "gene_name": "CDKN1C", "tax_name": "Human" }, { "uniprot_canonical_ac": "O96020-1", "protein_name": "G1/S-specific cyclin-E2", "gene_name": "CCNE2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00534-1", "protein_name": "Cyclin-dependent kinase 6", "gene_name": "CDK6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42773-1", "protein_name": "Cyclin-dependent kinase 4 inhibitor C", "gene_name": "CDKN2C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14186-1", "protein_name": "Transcription factor Dp-1", "gene_name": "TFDP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00716-1", "protein_name": "Transcription factor E2F3", "gene_name": "E2F3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14209-1", "protein_name": "Transcription factor E2F2", "gene_name": "E2F2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13882-1", "protein_name": "Protein-tyrosine kinase 6", "gene_name": "PTK6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00519-1", "protein_name": "Tyrosine-protein kinase ABL1", "gene_name": "ABL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63208-1", "protein_name": "S-phase kinase-associated protein 1", "gene_name": "SKP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30154-1", "protein_name": "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform", "gene_name": "PPP2R1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30153-1", "protein_name": "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "gene_name": "PPP2R1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P67775-1", "protein_name": "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform", "gene_name": "PPP2CA", 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"P06400", "url": "https://www.uniprot.org/uniprotkb/P06400" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 160, "end_pos": 160, "sequence_org": "F", "sequence_mut": "E", "comment": "Strongly diminishes interaction with HIRA.", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "PubMed", "id": "19029251", "url": "https://pubmed.ncbi.nlm.nih.gov/19029251" } ], "uniprot_canonical_ac": "Q9NPG3-1" }, { "start_pos": 162, "end_pos": 162, "sequence_org": "I", "sequence_mut": "E", "comment": "Strongly diminishes interaction with HIRA.", "evidence": [ { "database": "UniProtKB", "id": "Q9NPG3", "url": "https://www.uniprot.org/uniprotkb/Q9NPG3" }, { "database": "PubMed", "id": "19029251", "url": "https://pubmed.ncbi.nlm.nih.gov/19029251" } ], "uniprot_canonical_ac": "Q9NPG3-1" } ], "record_id": "pubmed.19029251", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 17 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "p27Kip1 inhibits cyclin D-cyclin-dependent kinase 4 by two independent modes.", "journal": "Molecular and cellular biology", "date": "2009", "authors": "Ray A, James MK, Larochelle S, Fisher RP, Blain SW", "reference": { "type": "PubMed", "id": "19075005", "url": "https://pubmed.ncbi.nlm.nih.gov/19075005" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P06400-1", "protein_name": "Retinoblastoma-associated protein", "gene_name": "RB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01094-1", "protein_name": "Transcription factor E2F1", "gene_name": "E2F1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61024-1", "protein_name": "Cyclin-dependent kinases regulatory subunit 1", "gene_name": "CKS1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13616-1", "protein_name": "Cullin-1", "gene_name": "CUL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60674-1", "protein_name": "Tyrosine-protein kinase JAK2", "gene_name": "JAK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13309-1", "protein_name": "S-phase kinase-associated protein 2", "gene_name": "SKP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62714-1", "protein_name": "Serine/threonine-protein phosphatase 2A catalytic subunit beta 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"CCNE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14188-1", "protein_name": "Transcription factor Dp-2", "gene_name": "TFDP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15329-1", "protein_name": "Transcription factor E2F5", "gene_name": "E2F5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16254-1", "protein_name": "Transcription factor E2F4", "gene_name": "E2F4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P28749-1", "protein_name": "Retinoblastoma-like protein 1", "gene_name": "RBL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P11802-1", "protein_name": "Cyclin-dependent kinase 4", "gene_name": "CDK4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30279-1", "protein_name": "G1/S-specific cyclin-D2", "gene_name": "CCND2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38936-1", "protein_name": "Cyclin-dependent kinase inhibitor 1", "gene_name": "CDKN1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P50613-1", "protein_name": "Cyclin-dependent kinase 7", "gene_name": "CDK7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24941-1", "protein_name": "Cyclin-dependent kinase 2", "gene_name": "CDK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49918-1", "protein_name": "Cyclin-dependent kinase inhibitor 1C", "gene_name": "CDKN1C", "tax_name": "Human" }, { "uniprot_canonical_ac": "O96020-1", "protein_name": "G1/S-specific cyclin-E2", "gene_name": "CCNE2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00534-1", "protein_name": "Cyclin-dependent kinase 6", "gene_name": "CDK6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42773-1", "protein_name": "Cyclin-dependent kinase 4 inhibitor C", "gene_name": "CDKN2C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14186-1", "protein_name": "Transcription factor Dp-1", "gene_name": "TFDP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00716-1", "protein_name": "Transcription factor E2F3", "gene_name": "E2F3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14209-1", "protein_name": "Transcription factor E2F2", "gene_name": "E2F2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13882-1", "protein_name": "Protein-tyrosine kinase 6", "gene_name": "PTK6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00519-1", "protein_name": "Tyrosine-protein kinase ABL1", "gene_name": "ABL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63208-1", "protein_name": "S-phase kinase-associated protein 1", "gene_name": "SKP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30154-1", "protein_name": "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform", "gene_name": "PPP2R1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30153-1", "protein_name": "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform", "gene_name": "PPP2R1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P67775-1", "protein_name": "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform", "gene_name": "PPP2CA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P06400", "url": "https://www.uniprot.org/uniprotkb/P06400" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 74, "end_pos": 74, "sequence_org": "Y", "sequence_mut": "F", "comment": "No change in binding CDK4 and no inhibition of CDK4 activity. Translocates to nucleus. No effect on in vitro phosphorylation of CDK4 by CCNH-CDK7.", "evidence": [ { "database": "UniProtKB", "id": "P46527", "url": "https://www.uniprot.org/uniprotkb/P46527" }, { "database": "PubMed", "id": "16195327", "url": "https://pubmed.ncbi.nlm.nih.gov/16195327" }, { "database": "PubMed", "id": "19075005", "url": "https://pubmed.ncbi.nlm.nih.gov/19075005" } ], "uniprot_canonical_ac": "P46527-1" }, { "start_pos": 88, "end_pos": 88, "sequence_org": "Y", "sequence_mut": "F", "comment": "Abolishes LYN-mediated phosphorylation, reduces CDK2-mediated phosphorylation on T-187, has greater cell cycle arrest into S-phase, no effect on binding CDK2 complexes, reduced CDK4 binding and inhibits CDK4 enzyme activity. No nuclear translocation. No effect on in vitro phosphorylation of CDK4 by CCNH-CDK7. Completely abolishes CDK4 binding; when associated with F-89.", "evidence": [ { "database": "UniProtKB", "id": "P46527", "url": "https://www.uniprot.org/uniprotkb/P46527" }, { "database": "PubMed", "id": "16195327", "url": "https://pubmed.ncbi.nlm.nih.gov/16195327" }, { "database": "PubMed", "id": "17254966", "url": "https://pubmed.ncbi.nlm.nih.gov/17254966" }, { "database": "PubMed", "id": "19075005", "url": "https://pubmed.ncbi.nlm.nih.gov/19075005" } ], "uniprot_canonical_ac": "P46527-1" }, { "start_pos": 89, "end_pos": 89, "sequence_org": "Y", "sequence_mut": "F", "comment": "No effect on binding CDK2 complexes, reduced CDK4 binding and greatly inhibits CDK4 enzyme activity. No nuclear translocation. Inhibits in vitro phosphorylation of CDK4 by CCNH-CDK7. Completely abolishes CDK4 binding; when associated with F-88.", "evidence": [ { "database": "UniProtKB", "id": "P46527", "url": "https://www.uniprot.org/uniprotkb/P46527" }, { "database": "PubMed", "id": "16195327", "url": "https://pubmed.ncbi.nlm.nih.gov/16195327" }, { "database": "PubMed", "id": "17254966", "url": "https://pubmed.ncbi.nlm.nih.gov/17254966" }, { "database": "PubMed", "id": "19075005", "url": "https://pubmed.ncbi.nlm.nih.gov/19075005" } ], "uniprot_canonical_ac": "P46527-1" } ], "record_id": "pubmed.19075005", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 46 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", 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"Human" }, { "uniprot_canonical_ac": "P62805-1", "protein_name": "Histone H4", "gene_name": "H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9", "tax_name": "Human" }, { "uniprot_canonical_ac": "P68431-1", "protein_name": "Histone H3.1", "gene_name": "H3C10; H3C11; H3C12; H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16778-1", "protein_name": "Histone H2B type 2-E", "gene_name": "H2BC21", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62807-1", "protein_name": "Histone H2B type 1-C/E/F/G/I", "gene_name": "H2BC10; H2BC4; H2BC6; H2BC7; H2BC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95347-1", "protein_name": "Structural maintenance of chromosomes protein 2", "gene_name": "SMC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NTJ3-1", "protein_name": "Structural maintenance of chromosomes protein 4", "gene_name": "SMC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86XI2-1", "protein_name": "Condensin-2 complex subunit G2", "gene_name": "NCAPG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q71DI3-1", "protein_name": "Histone H3.2", "gene_name": "H3C13; H3C14; H3C15", "tax_name": "Human" }, { "uniprot_canonical_ac": "P16104-1", "protein_name": "Histone H2AX", "gene_name": "H2AX", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NEM0-1", "protein_name": "Microcephalin", "gene_name": "MCPH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P33778-1", "protein_name": "Histone H2B type 1-B", "gene_name": "H2BC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P58876-1", "protein_name": "Histone H2B type 1-D", "gene_name": "H2BC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96A08-1", "protein_name": "Histone H2B type 1-A", "gene_name": "H2BC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P23527-1", "protein_name": "Histone H2B type 1-O", "gene_name": "H2BC17", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQR1-1", "protein_name": "N-lysine methyltransferase KMT5A", "gene_name": "KMT5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0C5Y9-1", "protein_name": "Histone H2A-Bbd type 1", "gene_name": "H2AB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BTM1-1", "protein_name": "Histone H2A.J", "gene_name": "H2AJ", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60814-1", "protein_name": "Histone H2B type 1-K", "gene_name": "H2BC12", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q93077-1", "protein_name": "Histone H2A type 1-C", "gene_name": "H2AC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q93079-1", "protein_name": "Histone H2B type 1-H", "gene_name": "H2BC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99879-1", "protein_name": "Histone H2B type 1-M", "gene_name": "H2BC14", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14635-1", "protein_name": "G2/mitotic-specific cyclin-B1", "gene_name": "CCNB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01105-1", "protein_name": "Protein SET", "gene_name": "SET", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q71UI9-1", "protein_name": "Histone H2A.V", "gene_name": "H2AZ2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04908-1", "protein_name": "Histone H2A type 1-B/E", "gene_name": "H2AC4; H2AC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06899-1", "protein_name": "Histone H2B type 1-J", "gene_name": "H2BC11", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20671-1", "protein_name": "Histone H2A type 1-D", "gene_name": "H2AC7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P57053-1", "protein_name": "Histone H2B type F-S", "gene_name": "H2BC12L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16777-1", "protein_name": "Histone H2A type 2-C", "gene_name": "H2AC20", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6FI13-1", "protein_name": "Histone H2A type 2-A", "gene_name": "H2AC18; H2AC19", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N257-1", "protein_name": "Histone H2B type 3-B", "gene_name": "H2BC26", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99877-1", "protein_name": "Histone H2B type 1-N", "gene_name": "H2BC15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99878-1", "protein_name": "Histone H2A type 1-J", "gene_name": "H2AC14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99880-1", "protein_name": "Histone H2B type 1-L", "gene_name": "H2BC13", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P06400", "url": "https://www.uniprot.org/uniprotkb/P06400" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.20551165", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 41 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", 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"o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive.", "journal": "Genes & development", "date": "2010", "authors": "Coschi CH, Martens AL, Ritchie K, Francis SM, Chakrabarti S, Berube NG, Dick FA", "reference": { "type": "PubMed", "id": "20551166", "url": "https://pubmed.ncbi.nlm.nih.gov/20551166" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P06400-1", "protein_name": "Retinoblastoma-associated 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"tax_name": "Human" }, { "uniprot_canonical_ac": "P68431-1", "protein_name": "Histone H3.1", "gene_name": "H3C10; H3C11; H3C12; H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16778-1", "protein_name": "Histone H2B type 2-E", "gene_name": "H2BC21", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62807-1", "protein_name": "Histone H2B type 1-C/E/F/G/I", "gene_name": "H2BC10; H2BC4; H2BC6; H2BC7; H2BC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95347-1", "protein_name": "Structural maintenance of chromosomes protein 2", "gene_name": "SMC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NTJ3-1", "protein_name": "Structural maintenance of chromosomes protein 4", "gene_name": "SMC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86XI2-1", "protein_name": "Condensin-2 complex subunit G2", "gene_name": "NCAPG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q71DI3-1", "protein_name": "Histone H3.2", "gene_name": "H3C13; H3C14; H3C15", "tax_name": "Human" }, { "uniprot_canonical_ac": "P16104-1", "protein_name": "Histone H2AX", "gene_name": "H2AX", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NEM0-1", "protein_name": "Microcephalin", "gene_name": "MCPH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P33778-1", "protein_name": "Histone H2B type 1-B", "gene_name": "H2BC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P58876-1", "protein_name": "Histone H2B type 1-D", "gene_name": "H2BC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96A08-1", "protein_name": "Histone H2B type 1-A", "gene_name": "H2BC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P23527-1", "protein_name": "Histone H2B type 1-O", "gene_name": "H2BC17", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQR1-1", "protein_name": "N-lysine methyltransferase KMT5A", "gene_name": "KMT5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0C5Y9-1", "protein_name": "Histone H2A-Bbd type 1", "gene_name": "H2AB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BTM1-1", "protein_name": "Histone H2A.J", "gene_name": "H2AJ", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60814-1", "protein_name": "Histone H2B type 1-K", "gene_name": "H2BC12", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q93077-1", "protein_name": "Histone H2A type 1-C", "gene_name": "H2AC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q93079-1", "protein_name": "Histone H2B type 1-H", "gene_name": "H2BC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99879-1", "protein_name": "Histone H2B type 1-M", "gene_name": "H2BC14", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14635-1", "protein_name": "G2/mitotic-specific cyclin-B1", "gene_name": "CCNB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01105-1", "protein_name": "Protein SET", "gene_name": "SET", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q71UI9-1", "protein_name": "Histone H2A.V", "gene_name": "H2AZ2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04908-1", "protein_name": "Histone H2A type 1-B/E", "gene_name": "H2AC4; H2AC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06899-1", "protein_name": "Histone H2B type 1-J", "gene_name": "H2BC11", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20671-1", "protein_name": "Histone H2A type 1-D", "gene_name": "H2AC7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P57053-1", "protein_name": "Histone H2B type F-S", "gene_name": "H2BC12L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16777-1", "protein_name": "Histone H2A type 2-C", "gene_name": "H2AC20", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6FI13-1", "protein_name": "Histone H2A type 2-A", "gene_name": "H2AC18; H2AC19", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N257-1", "protein_name": "Histone H2B type 3-B", "gene_name": "H2BC26", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99877-1", "protein_name": "Histone H2B type 1-N", "gene_name": "H2BC15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99878-1", "protein_name": "Histone H2A type 1-J", "gene_name": "H2AC14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99880-1", "protein_name": "Histone H2B type 1-L", "gene_name": "H2BC13", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P06400", "url": "https://www.uniprot.org/uniprotkb/P06400" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.20551166", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 41 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", 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"o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis.", "journal": "Oncogene", "date": "2011", "authors": "Delston RB, Matatall KA, Sun Y, Onken MD, Harbour JW", "reference": { "type": "PubMed", "id": "20871633", "url": "https://pubmed.ncbi.nlm.nih.gov/20871633" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P06400-1", "protein_name": "Retinoblastoma-associated protein", "gene_name": "RB1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P06400", "url": "https://www.uniprot.org/uniprotkb/P06400" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "phosphorylation": [ { "start_pos": 567, "end_pos": 567, "kinase_uniprot_canonical_ac": "Q16539-1", "kinase_gene_name": "MAPK14", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P06400", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P06400" }, { "database": "PubMed", "id": "20871633", "url": "https://pubmed.ncbi.nlm.nih.gov/20871633" } ], "site_lbl": "Ser567", "uniprot_canonical_ac": "P06400-1" } ], "record_id": "pubmed.20871633", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { 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"count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation.", "journal": "Journal of cell science", "date": "2010", "authors": "Pickard A, Wong PP, McCance DJ", "reference": { "type": "PubMed", "id": "20940255", "url": "https://pubmed.ncbi.nlm.nih.gov/20940255" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P06400-1", "protein_name": "Retinoblastoma-associated protein", "gene_name": "RB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P13405-1", "protein_name": "Retinoblastoma-associated protein", "gene_name": "Rb1", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "B2RWS6-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "Ep300", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92831-1", "protein_name": "Histone acetyltransferase KAT2B", "gene_name": "KAT2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9JHD1-1", "protein_name": "Histone acetyltransferase KAT2B", "gene_name": "Kat2b", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q61501-1", "protein_name": "Transcription factor E2F1", "gene_name": "E2f1", "tax_name": "Mouse" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P06400", "url": "https://www.uniprot.org/uniprotkb/P06400" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 873, "end_pos": 874, "sequence_org": "KK", "sequence_mut": "RR", "comment": "Does not alter Rb localization in cycling cells, but mislocalizes to the cytoplasm during keratinocyte differentiation. Does not affect the ability to arrest cell growth. Probable loss of acetylation by PCAF.", "evidence": [ { "database": "UniProtKB", "id": "P06400", "url": "https://www.uniprot.org/uniprotkb/P06400" }, { "database": "PubMed", "id": "20940255", "url": "https://pubmed.ncbi.nlm.nih.gov/20940255" }, { "database": "PubMed", "id": "20870719", "url": "https://pubmed.ncbi.nlm.nih.gov/20870719" } ], "uniprot_canonical_ac": "P06400-1" }, { "start_pos": 873, "end_pos": 874, "sequence_org": "KK", "sequence_mut": "R", "comment": "Does not affect the ability to be methylated by SMYD2; when associated with 873-R-R-874.", "evidence": [ { "database": "UniProtKB", "id": "P06400", "url": "https://www.uniprot.org/uniprotkb/P06400" }, { "database": "PubMed", "id": "20940255", "url": "https://pubmed.ncbi.nlm.nih.gov/20940255" }, { "database": "PubMed", "id": "20870719", "url": "https://pubmed.ncbi.nlm.nih.gov/20870719" } ], "uniprot_canonical_ac": "P06400-1" } ], "record_id": "pubmed.20940255", "abstract": "", "glycosylation": [], "snv": [], 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}, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "p57Kip2 is a downstream effector of BCR-ABL kinase inhibitors in chronic myelogenous leukemia cells.", "journal": "Carcinogenesis", "date": "2011", "authors": "Borriello A, Caldarelli I, Bencivenga D, Cucciolla V, Oliva A, Usala E, Danise P, Ronzoni L, Perrotta S, Della Ragione F", "reference": { "type": "PubMed", "id": "20952511", "url": "https://pubmed.ncbi.nlm.nih.gov/20952511" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P06400-1", "protein_name": "Retinoblastoma-associated protein", "gene_name": "RB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01094-1", "protein_name": "Transcription factor E2F1", "gene_name": "E2F1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61024-1", "protein_name": "Cyclin-dependent kinases regulatory subunit 1", "gene_name": "CKS1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13616-1", "protein_name": "Cullin-1", "gene_name": "CUL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60674-1", "protein_name": "Tyrosine-protein kinase JAK2", "gene_name": "JAK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13309-1", "protein_name": "S-phase kinase-associated protein 2", "gene_name": "SKP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62714-1", "protein_name": "Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform", "gene_name": "PPP2CB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42771-1", "protein_name": "Cyclin-dependent kinase inhibitor 2A", "gene_name": "CDKN2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42772-1", "protein_name": "Cyclin-dependent kinase 4 inhibitor B", "gene_name": "CDKN2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30281-1", "protein_name": "G1/S-specific cyclin-D3", "gene_name": "CCND3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5P8-1", "protein_name": "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta", "gene_name": "PPP2R3B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08999-1", "protein_name": "Retinoblastoma-like protein 2", "gene_name": "RBL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P51948-1", "protein_name": "CDK-activating kinase assembly factor MAT1", "gene_name": "MNAT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P51946-1", "protein_name": "Cyclin-H", "gene_name": "CCNH", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63151-1", "protein_name": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform", "gene_name": "PPP2R2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P07948-1", "protein_name": "Tyrosine-protein kinase Lyn", "gene_name": "LYN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24385-1", "protein_name": "G1/S-specific cyclin-D1", "gene_name": "CCND1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46527-1", "protein_name": "Cyclin-dependent kinase inhibitor 1B", "gene_name": "CDKN1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55273-1", "protein_name": "Cyclin-dependent kinase 4 inhibitor D", "gene_name": "CDKN2D", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24864-1", "protein_name": "G1/S-specific cyclin-E1", "gene_name": "CCNE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14188-1", "protein_name": "Transcription factor Dp-2", "gene_name": "TFDP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15329-1", "protein_name": "Transcription factor E2F5", "gene_name": "E2F5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16254-1", "protein_name": "Transcription factor E2F4", "gene_name": "E2F4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P28749-1", "protein_name": "Retinoblastoma-like protein 1", "gene_name": "RBL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P11802-1", "protein_name": "Cyclin-dependent kinase 4", "gene_name": "CDK4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30279-1", "protein_name": "G1/S-specific cyclin-D2", "gene_name": "CCND2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38936-1", "protein_name": "Cyclin-dependent kinase inhibitor 1", "gene_name": "CDKN1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P50613-1", "protein_name": "Cyclin-dependent kinase 7", "gene_name": "CDK7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24941-1", "protein_name": "Cyclin-dependent kinase 2", "gene_name": "CDK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49918-1", "protein_name": "Cyclin-dependent kinase inhibitor 1C", "gene_name": "CDKN1C", "tax_name": "Human" }, { "uniprot_canonical_ac": "O96020-1", "protein_name": "G1/S-specific cyclin-E2", "gene_name": "CCNE2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00534-1", "protein_name": "Cyclin-dependent kinase 6", "gene_name": "CDK6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42773-1", "protein_name": "Cyclin-dependent kinase 4 inhibitor C", "gene_name": "CDKN2C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14186-1", "protein_name": "Transcription factor Dp-1", "gene_name": "TFDP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00716-1", "protein_name": "Transcription factor E2F3", "gene_name": "E2F3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14209-1", "protein_name": "Transcription factor E2F2", "gene_name": "E2F2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13882-1", "protein_name": "Protein-tyrosine kinase 6", "gene_name": "PTK6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00519-1", "protein_name": "Tyrosine-protein kinase ABL1", "gene_name": "ABL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63208-1", "protein_name": "S-phase kinase-associated protein 1", "gene_name": "SKP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30154-1", "protein_name": "Serine/threonine-protein 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"tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl", "uniprot_canonical_ac" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II.", "journal": "Genes & development", "date": "2011", "authors": "Abe S, Nagasaka K, Hirayama Y, Kozuka-Hata H, Oyama M, Aoyagi Y, Obuse C, Hirota T", "reference": { "type": "PubMed", "id": "21498573", "url": "https://pubmed.ncbi.nlm.nih.gov/21498573" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P06400-1", "protein_name": "Retinoblastoma-associated protein", "gene_name": "RB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19784-1", "protein_name": "Casein kinase II subunit alpha'", "gene_name": "CSNK2A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53350-1", "protein_name": "Serine/threonine-protein kinase PLK1", "gene_name": "PLK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P84243-1", "protein_name": "Histone H3.3", "gene_name": "H3-3A; H3-3B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06493-1", "protein_name": "Cyclin-dependent kinase 1", "gene_name": "CDK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42695-1", "protein_name": "Condensin-2 complex subunit D3", "gene_name": "NCAPD3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6IBW4-1", "protein_name": "Condensin-2 complex subunit H2", "gene_name": "NCAPH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16695-1", "protein_name": "Histone H3.1t", "gene_name": "H3-4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62805-1", "protein_name": "Histone H4", "gene_name": "H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9", "tax_name": "Human" }, { "uniprot_canonical_ac": "P68431-1", "protein_name": "Histone H3.1", "gene_name": "H3C10; H3C11; H3C12; H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16778-1", "protein_name": "Histone H2B type 2-E", "gene_name": "H2BC21", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62807-1", "protein_name": "Histone H2B type 1-C/E/F/G/I", "gene_name": "H2BC10; H2BC4; H2BC6; H2BC7; H2BC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95347-1", "protein_name": "Structural maintenance of chromosomes protein 2", "gene_name": "SMC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NTJ3-1", "protein_name": "Structural maintenance of chromosomes protein 4", "gene_name": "SMC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15021-1", "protein_name": "Condensin complex subunit 1", "gene_name": "NCAPD2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15003-1", "protein_name": "Condensin complex subunit 2", "gene_name": "NCAPH", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BPX3-1", "protein_name": "Condensin complex subunit 3", "gene_name": "NCAPG", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86XI2-1", "protein_name": "Condensin-2 complex subunit G2", "gene_name": "NCAPG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q71DI3-1", "protein_name": "Histone H3.2", "gene_name": "H3C13; H3C14; H3C15", "tax_name": "Human" }, { "uniprot_canonical_ac": "P16104-1", "protein_name": "Histone H2AX", "gene_name": "H2AX", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NEM0-1", "protein_name": "Microcephalin", "gene_name": "MCPH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P33778-1", "protein_name": "Histone H2B type 1-B", "gene_name": "H2BC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P58876-1", "protein_name": "Histone H2B type 1-D", "gene_name": "H2BC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96A08-1", "protein_name": "Histone H2B type 1-A", "gene_name": "H2BC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P23527-1", "protein_name": "Histone H2B type 1-O", "gene_name": "H2BC17", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQR1-1", "protein_name": "N-lysine methyltransferase KMT5A", "gene_name": "KMT5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0C5Y9-1", "protein_name": "Histone H2A-Bbd type 1", "gene_name": "H2AB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BTM1-1", "protein_name": "Histone H2A.J", "gene_name": "H2AJ", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60814-1", "protein_name": "Histone H2B type 1-K", "gene_name": "H2BC12", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q93077-1", "protein_name": "Histone H2A type 1-C", "gene_name": "H2AC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q93079-1", "protein_name": "Histone H2B type 1-H", "gene_name": "H2BC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99879-1", "protein_name": "Histone H2B type 1-M", "gene_name": "H2BC14", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95067-1", "protein_name": "G2/mitotic-specific cyclin-B2", "gene_name": "CCNB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P68400-1", "protein_name": "Casein kinase II subunit alpha", "gene_name": "CSNK2A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P67870-1", "protein_name": "Casein kinase II subunit beta", "gene_name": "CSNK2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14635-1", "protein_name": "G2/mitotic-specific cyclin-B1", "gene_name": "CCNB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01105-1", "protein_name": "Protein SET", "gene_name": "SET", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q71UI9-1", "protein_name": "Histone H2A.V", "gene_name": "H2AZ2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04908-1", "protein_name": "Histone H2A type 1-B/E", "gene_name": "H2AC4; H2AC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06899-1", "protein_name": "Histone H2B type 1-J", "gene_name": "H2BC11", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20671-1", "protein_name": "Histone H2A type 1-D", "gene_name": "H2AC7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P57053-1", "protein_name": "Histone H2B type F-S", "gene_name": "H2BC12L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16777-1", "protein_name": "Histone H2A type 2-C", "gene_name": "H2AC20", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6FI13-1", "protein_name": "Histone H2A type 2-A", "gene_name": "H2AC18; H2AC19", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N257-1", "protein_name": "Histone H2B type 3-B", "gene_name": "H2BC26", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99877-1", "protein_name": "Histone H2B type 1-N", "gene_name": "H2BC15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99878-1", "protein_name": "Histone H2A type 1-J", "gene_name": "H2AC14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99880-1", "protein_name": "Histone H2B type 1-L", "gene_name": "H2BC13", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P06400", "url": "https://www.uniprot.org/uniprotkb/P06400" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "phosphorylation": [ { "start_pos": 1415, "end_pos": 1415, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "P42695", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P42695" }, { "database": "PubMed", "id": "21498573", "url": 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"field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "SET nuclear oncogene associates with microcephalin/MCPH1 and regulates chromosome condensation.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Leung JW, Leitch A, Wood JL, Shaw-Smith C, Metcalfe K, Bicknell LS, Jackson AP, Chen J", "reference": { "type": "PubMed", "id": "21515671", "url": "https://pubmed.ncbi.nlm.nih.gov/21515671" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P06400-1", "protein_name": "Retinoblastoma-associated protein", "gene_name": "RB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P53350-1", "protein_name": "Serine/threonine-protein kinase PLK1", "gene_name": "PLK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P84243-1", "protein_name": "Histone H3.3", "gene_name": "H3-3A; H3-3B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06493-1", "protein_name": 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"tax_name": "Human" }, { "uniprot_canonical_ac": "P58876-1", "protein_name": "Histone H2B type 1-D", "gene_name": "H2BC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96A08-1", "protein_name": "Histone H2B type 1-A", "gene_name": "H2BC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P23527-1", "protein_name": "Histone H2B type 1-O", "gene_name": "H2BC17", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQR1-1", "protein_name": "N-lysine methyltransferase KMT5A", "gene_name": "KMT5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0C5Y9-1", "protein_name": "Histone H2A-Bbd type 1", "gene_name": "H2AB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BTM1-1", "protein_name": "Histone H2A.J", "gene_name": "H2AJ", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60814-1", "protein_name": "Histone H2B type 1-K", "gene_name": "H2BC12", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q93077-1", "protein_name": "Histone H2A type 1-C", "gene_name": "H2AC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q93079-1", "protein_name": "Histone H2B type 1-H", "gene_name": "H2BC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99879-1", "protein_name": "Histone H2B type 1-M", "gene_name": "H2BC14", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14635-1", "protein_name": "G2/mitotic-specific cyclin-B1", "gene_name": "CCNB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01105-1", "protein_name": "Protein SET", "gene_name": "SET", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q71UI9-1", "protein_name": "Histone H2A.V", "gene_name": "H2AZ2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04908-1", "protein_name": "Histone H2A type 1-B/E", "gene_name": "H2AC4; H2AC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06899-1", "protein_name": "Histone H2B type 1-J", "gene_name": "H2BC11", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20671-1", "protein_name": "Histone H2A type 1-D", "gene_name": "H2AC7", "tax_name": 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"url": "https://www.uniprot.org/uniprotkb/P06400" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.21515671", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 41 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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Cdk4/cyclin D complex activation by tyrosine phosphorylation of inhibitor p27 protein.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Ou L, Ferreira AM, Otieno S, Xiao L, Bashford D, Kriwacki RW", "reference": { "type": "PubMed", "id": "21715330", "url": "https://pubmed.ncbi.nlm.nih.gov/21715330" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P06400-1", "protein_name": "Retinoblastoma-associated protein", "gene_name": "RB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q01094-1", "protein_name": "Transcription factor E2F1", "gene_name": "E2F1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P61024-1", "protein_name": "Cyclin-dependent kinases regulatory subunit 1", "gene_name": "CKS1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13616-1", "protein_name": "Cullin-1", "gene_name": "CUL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60674-1", "protein_name": "Tyrosine-protein kinase JAK2", "gene_name": "JAK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13309-1", "protein_name": "S-phase kinase-associated protein 2", "gene_name": "SKP2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62714-1", "protein_name": "Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform", "gene_name": "PPP2CB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42771-1", "protein_name": "Cyclin-dependent kinase inhibitor 2A", "gene_name": "CDKN2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42772-1", "protein_name": "Cyclin-dependent kinase 4 inhibitor B", "gene_name": "CDKN2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P30281-1", "protein_name": "G1/S-specific cyclin-D3", "gene_name": "CCND3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5P8-1", "protein_name": "Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta", "gene_name": "PPP2R3B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q08999-1", "protein_name": 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"P30279-1", "protein_name": "G1/S-specific cyclin-D2", "gene_name": "CCND2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P38936-1", "protein_name": "Cyclin-dependent kinase inhibitor 1", "gene_name": "CDKN1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P50613-1", "protein_name": "Cyclin-dependent kinase 7", "gene_name": "CDK7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24941-1", "protein_name": "Cyclin-dependent kinase 2", "gene_name": "CDK2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49918-1", "protein_name": "Cyclin-dependent kinase inhibitor 1C", "gene_name": "CDKN1C", "tax_name": "Human" }, { "uniprot_canonical_ac": "O96020-1", "protein_name": "G1/S-specific cyclin-E2", "gene_name": "CCNE2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00534-1", "protein_name": "Cyclin-dependent kinase 6", "gene_name": "CDK6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42773-1", "protein_name": "Cyclin-dependent kinase 4 inhibitor C", "gene_name": 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Gross J, Hartmann L, Huang M, Huntsman D, Iacocca M, Imielinski M, Kalloger S, Karlan B, Levine D, Mills G, Morrison C, Mutch D, Olvera N, Orsulic S, Park K, Petrelli N, Rabeno B, Rader J, Sikic B, Smith-McCune K, Sood A, Bowtell D, Penny R, Testa J, Chang K, Dinh H, Drummond J, Fowler G, Gunaratne P, Hawes A, Kovar C, Lewis L, Morgan M, Newsham I, Santibanez J, Reid J, Trevino L, Wu Y-, Wang M, Muzny D, Wheeler D, Gibbs R, Getz G, Lawrence M, Cibulskis K, Sivachenko A, Sougnez C, Voet D, Wilkinson J, Bloom T, Ardlie K, Fennell T, Baldwin J, Gabriel S, Lander E, Ding LL, Fulton R, Koboldt D, McLellan M, Wylie T, Walker J, O'Laughlin M, Dooling D, Fulton L, Abbott R, Dees N, Zhang Q, Kandoth C, Wendl M, Schierding W, Shen D, Harris C, Schmidt H, Kalicki J, Delehaunty K, Fronick C, Demeter R, Cook L, Wallis J, Lin L, Magrini V, Hodges J, Eldred J, Smith S, Pohl C, Vandin F, Raphael B, Weinstock G, Mardis E, Wilson R, Meyerson M, Winckler W, Getz G, Verhaak R, Carter S, Mermel C, Saksena 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