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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system.", "journal": "Oncogene", "date": "1997", "authors": "Iwahara T, Fujimoto J, Wen D, Cupples R, Bucay N, Arakawa T, Mori S, Ratzkin B, Yamamoto T", "reference": { "type": "PubMed", "id": "9053841", "url": "https://pubmed.ncbi.nlm.nih.gov/9053841" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UM73-1", "protein_name": "ALK tyrosine kinase receptor", "gene_name": "ALK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P97793-1", "protein_name": "ALK tyrosine kinase receptor", "gene_name": "Alk", "tax_name": "Mouse" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9UM73", "url": "https://www.uniprot.org/uniprotkb/Q9UM73" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.9053841", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { 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"evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "10202154", "url": "https://pubmed.ncbi.nlm.nih.gov/10202154" }, { "database": "PubMed", "id": "12914934", "url": "https://pubmed.ncbi.nlm.nih.gov/12914934" } ], "uniprot_canonical_ac": "Q16665-1" }, { "start_pos": 844, "end_pos": 844, "sequence_org": "C", "sequence_mut": "S", "comment": "Abolishes hypoxia-inducible transcriptional activation of ctaD.", "evidence": [ { "database": "UniProtKB", "id": "Q99814", "url": "https://www.uniprot.org/uniprotkb/Q99814" }, { "database": "PubMed", "id": "10202154", "url": "https://pubmed.ncbi.nlm.nih.gov/10202154" } ], "uniprot_canonical_ac": "Q99814-1" } ], "record_id": "pubmed.10202154", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 10 } ], "sort_fields": [ 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"uniprot_canonical_ac": "O76050-1", "protein_name": "E3 ubiquitin-protein ligase NEURL1", "gene_name": "NEURL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92830-1", "protein_name": "Histone acetyltransferase KAT2A", "gene_name": "KAT2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62877-1", "protein_name": "E3 ubiquitin-protein ligase RBX1", "gene_name": "RBX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86YT6-1", "protein_name": "E3 ubiquitin-protein ligase MIB1", "gene_name": "MIB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96JK9-1", "protein_name": "Mastermind-like protein 3", "gene_name": "MAML3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00548-1", "protein_name": "Delta-like protein 1", "gene_name": "DLL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15379-1", "protein_name": "Histone deacetylase 3", "gene_name": "HDAC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WUI4-1", "protein_name": "Histone deacetylase 7", "gene_name": "HDAC7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQL6-1", "protein_name": "Histone deacetylase 5", "gene_name": "HDAC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WW43-1", "protein_name": "Gamma-secretase subunit APH-1B", "gene_name": "APH1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UKV0-1", "protein_name": "Histone deacetylase 9", "gene_name": "HDAC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92769-1", "protein_name": "Histone deacetylase 2", "gene_name": "HDAC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01106-2", "protein_name": "Myc proto-oncogene protein", "gene_name": "MYC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96DB2-1", 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"gene_name": "CCNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49336-1", "protein_name": "Cyclin-dependent kinase 8", "gene_name": "CDK8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04725-1", "protein_name": "Transducin-like enhancer protein 2", "gene_name": "TLE2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75376-1", "protein_name": "Nuclear receptor corepressor 1", "gene_name": "NCOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13573-1", "protein_name": "SNW domain-containing protein 1", "gene_name": "SNW1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49810-1", "protein_name": "Presenilin-2", "gene_name": "PSEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5J3-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 1", "gene_name": "HEY1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y219-1", "protein_name": "Protein jagged-2", "gene_name": "JAG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY41-1", "protein_name": "Histone deacetylase 8", "gene_name": "HDAC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14469-1", "protein_name": "Transcription factor HES-1", "gene_name": "HES1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13495-1", "protein_name": "Mastermind-like domain-containing protein 1", "gene_name": "MAMLD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92585-1", "protein_name": "Mastermind-like protein 1", "gene_name": "MAML1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04727-1", "protein_name": "Transducin-like enhancer protein 4", "gene_name": "TLE4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49768-1", "protein_name": "Presenilin-1", "gene_name": "PSEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14672-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56524-1", "protein_name": "Histone deacetylase 4", "gene_name": "HDAC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63208-1", "protein_name": "S-phase kinase-associated protein 1", "gene_name": "SKP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10713164", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 65 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2000", "authors": "Sutter CH, Laughner E, Semenza GL", "reference": { "type": "PubMed", "id": "10758161", "url": "https://pubmed.ncbi.nlm.nih.gov/10758161" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 551, "end_pos": 551, "sequence_org": "S", "sequence_mut": "G", "comment": "Constitutive expression under nonhypoxic conditions by decreasing ubiquitination.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "10758161", "url": "https://pubmed.ncbi.nlm.nih.gov/10758161" } ], "uniprot_canonical_ac": "Q16665-1" }, { "start_pos": 552, "end_pos": 552, "sequence_org": "T", "sequence_mut": "A", "comment": "Constitutive expression under nonhypoxic conditions by decreasing ubiquitination.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "10758161", "url": "https://pubmed.ncbi.nlm.nih.gov/10758161" } ], "uniprot_canonical_ac": "Q16665-1" } ], "record_id": "pubmed.10758161", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2000", "authors": "Aso T, Yamazaki K, Aigaki T, Kitajima S", "reference": { "type": "PubMed", "id": "11006129", "url": "https://pubmed.ncbi.nlm.nih.gov/11006129" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15369-1", "protein_name": "Elongin-C", "gene_name": "ELOC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15370-1", "protein_name": "Elongin-B", "gene_name": "ELOB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9V3C1-1", "protein_name": "Protein Vhl", "gene_name": "Vhl", "tax_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q24167-1", "protein_name": "Protein similar", "gene_name": "sima", "tax_name": "Fruit fly" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11006129", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos.", "journal": "Mechanisms of development", "date": "2000", "authors": "Leimeister C, Schumacher N, Steidl C, Gessler M", "reference": { "type": "PubMed", "id": "11044625", "url": "https://pubmed.ncbi.nlm.nih.gov/11044625" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y618-1", "protein_name": "Nuclear receptor corepressor 2", "gene_name": "NCOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P78536-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 17", "gene_name": "ADAM17", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92542-1", "protein_name": "Nicastrin", "gene_name": "NCSTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96BI3-1", "protein_name": "Gamma-secretase subunit APH-1A", "gene_name": "APH1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13616-1", "protein_name": "Cullin-1", "gene_name": "CUL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13547-1", "protein_name": "Histone deacetylase 1", "gene_name": "HDAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NR61-1", "protein_name": "Delta-like protein 4", "gene_name": "DLL4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NZ42-1", "protein_name": "Gamma-secretase subunit PEN-2", "gene_name": "PSENEN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5TA89-1", "protein_name": "Transcription factor HES-5", "gene_name": "HES5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96AX9-1", "protein_name": "E3 ubiquitin-protein ligase MIB2", "gene_name": "MIB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "A8MQ27-1", "protein_name": "E3 ubiquitin-protein ligase NEURL1B", "gene_name": "NEURL1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60907-1", "protein_name": "F-box-like/WD repeat-containing protein TBL1X", "gene_name": "TBL1X", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46531-1", "protein_name": "Neurogenic locus notch homolog protein 1", "gene_name": "NOTCH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06330-1", "protein_name": "Recombining binding protein suppressor of hairless", "gene_name": "RBPJ", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BZK7-1", "protein_name": "F-box-like/WD repeat-containing protein TBL1XR1", "gene_name": "TBL1XR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBN7-1", "protein_name": "Protein deacetylase HDAC6", "gene_name": "HDAC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P78504-1", "protein_name": "Protein jagged-1", "gene_name": "JAG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IZL2-1", "protein_name": "Mastermind-like protein 2", "gene_name": "MAML2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76050-1", "protein_name": "E3 ubiquitin-protein ligase NEURL1", "gene_name": "NEURL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92830-1", "protein_name": "Histone acetyltransferase KAT2A", "gene_name": "KAT2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62877-1", "protein_name": "E3 ubiquitin-protein ligase RBX1", "gene_name": "RBX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86YT6-1", "protein_name": "E3 ubiquitin-protein ligase MIB1", "gene_name": "MIB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96JK9-1", "protein_name": "Mastermind-like protein 3", "gene_name": "MAML3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00548-1", "protein_name": "Delta-like protein 1", "gene_name": "DLL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15379-1", "protein_name": "Histone deacetylase 3", "gene_name": "HDAC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WUI4-1", "protein_name": "Histone deacetylase 7", "gene_name": "HDAC7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQL6-1", 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}, { "uniprot_canonical_ac": "Q04724-1", "protein_name": "Transducin-like enhancer protein 1", "gene_name": "TLE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ87-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif-like protein", "gene_name": "HEYL", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9DBX7-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif-like protein", "gene_name": "Heyl", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q969S8-1", "protein_name": "Polyamine deacetylase HDAC10", "gene_name": "HDAC10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBP5-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 2", "gene_name": "HEY2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFP9-1", "protein_name": "Neurobeachin", "gene_name": "NBEA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92831-1", "protein_name": "Histone acetyltransferase KAT2B", "gene_name": "KAT2B", "tax_name": "Human" 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A leucine-rich interface regulated by a single cysteine.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Gu J, Milligan J, Huang LE", "reference": { "type": "PubMed", "id": "11063749", "url": "https://pubmed.ncbi.nlm.nih.gov/11063749" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27540-1", "protein_name": "Aryl hydrocarbon receptor nuclear translocator", "gene_name": "ARNT", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99967-1", "protein_name": "Cbp/p300-interacting transactivator 2", "gene_name": "CITED2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99814-1", "protein_name": "Endothelial PAS domain-containing protein 1", "gene_name": "EPAS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16790-1", "protein_name": "Carbonic anhydrase 9", "gene_name": "CA9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y241-1", "protein_name": "HIG1 domain family member 1A, mitochondrial", "gene_name": "HIGD1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15692-13", "protein_name": "Vascular endothelial growth factor A, long form", "gene_name": "VEGFA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01588-1", "protein_name": "Erythropoietin", "gene_name": "EPO", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11063749", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 10 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "A model for the complex between the hypoxia-inducible factor-1 (HIF-1) and its consensus DNA sequence.", "journal": "J. Biomol. Struct. Dyn.", "date": "2000", "authors": "Michel G, Minet E, Ernest I, Roland I, Durant F, Remacle J, Michiels C", "reference": { "type": "PubMed", "id": "11089639", "url": "https://pubmed.ncbi.nlm.nih.gov/11089639" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11089639", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { 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"glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Oberg C, Li J, Pauley A, Wolf E, Gurney M, Lendahl U", "reference": { "type": "PubMed", "id": "11461910", "url": "https://pubmed.ncbi.nlm.nih.gov/11461910" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y618-1", "protein_name": "Nuclear receptor corepressor 2", "gene_name": "NCOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13616-1", "protein_name": "Cullin-1", "gene_name": "CUL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13547-1", "protein_name": "Histone deacetylase 1", "gene_name": "HDAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8VBV4-2", "protein_name": "F-box/WD repeat-containing protein 7", "gene_name": "Fbxw7", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q5TA89-1", "protein_name": "Transcription factor HES-5", "gene_name": "HES5", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60907-1", "protein_name": "F-box-like/WD repeat-containing protein TBL1X", "gene_name": "TBL1X", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46531-1", "protein_name": "Neurogenic locus notch homolog protein 1", "gene_name": "NOTCH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06330-1", "protein_name": "Recombining binding protein suppressor of hairless", "gene_name": "RBPJ", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BZK7-1", "protein_name": "F-box-like/WD repeat-containing protein TBL1XR1", "gene_name": "TBL1XR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBN7-1", "protein_name": "Protein deacetylase HDAC6", "gene_name": "HDAC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IZL2-1", "protein_name": "Mastermind-like protein 2", "gene_name": "MAML2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92830-1", "protein_name": "Histone acetyltransferase KAT2A", "gene_name": "KAT2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62877-1", "protein_name": "E3 ubiquitin-protein ligase RBX1", "gene_name": "RBX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96JK9-1", "protein_name": "Mastermind-like protein 3", "gene_name": "MAML3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15379-1", "protein_name": "Histone deacetylase 3", "gene_name": "HDAC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WUI4-1", "protein_name": "Histone deacetylase 7", "gene_name": "HDAC7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQL6-1", "protein_name": "Histone deacetylase 5", "gene_name": "HDAC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UKV0-1", "protein_name": "Histone deacetylase 9", "gene_name": "HDAC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92769-1", "protein_name": "Histone deacetylase 2", "gene_name": "HDAC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01106-2", "protein_name": "Myc proto-oncogene protein", "gene_name": "MYC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96DB2-1", "protein_name": "Histone deacetylase 11", "gene_name": "HDAC11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04724-1", "protein_name": "Transducin-like enhancer protein 1", "gene_name": "TLE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ87-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif-like protein", "gene_name": "HEYL", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q969S8-1", "protein_name": "Polyamine deacetylase HDAC10", "gene_name": "HDAC10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBP5-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 2", "gene_name": "HEY2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFP9-1", "protein_name": "Neurobeachin", "gene_name": "NBEA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92831-1", "protein_name": "Histone acetyltransferase KAT2B", "gene_name": "KAT2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24863-1", "protein_name": "Cyclin-C", "gene_name": "CCNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49336-1", "protein_name": "Cyclin-dependent kinase 8", "gene_name": "CDK8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04725-1", "protein_name": "Transducin-like enhancer protein 2", "gene_name": "TLE2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75376-1", "protein_name": "Nuclear receptor corepressor 1", "gene_name": "NCOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13573-1", "protein_name": "SNW domain-containing protein 1", "gene_name": "SNW1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5J3-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 1", "gene_name": "HEY1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY41-1", "protein_name": "Histone deacetylase 8", "gene_name": "HDAC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14469-1", "protein_name": "Transcription factor HES-1", "gene_name": "HES1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13495-1", "protein_name": "Mastermind-like domain-containing protein 1", "gene_name": "MAMLD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92585-1", "protein_name": "Mastermind-like protein 1", "gene_name": "MAML1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04727-1", "protein_name": "Transducin-like enhancer protein 4", "gene_name": "TLE4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56524-1", "protein_name": "Histone deacetylase 4", "gene_name": "HDAC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63208-1", "protein_name": "S-phase kinase-associated protein 1", "gene_name": "SKP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11461910", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 47 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation.", "journal": "The EMBO journal", "date": "2001", "authors": "Masson N, Willam C, Maxwell PH, Pugh CW, Ratcliffe PJ", "reference": { "type": "PubMed", "id": "11566883", "url": "https://pubmed.ncbi.nlm.nih.gov/11566883" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 394, "end_pos": 394, "sequence_org": "P", "sequence_mut": "A", "comment": "No change in VHLE3-dependent ubiquitination.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "11566883", "url": "https://pubmed.ncbi.nlm.nih.gov/11566883" } ], "uniprot_canonical_ac": "Q16665-1" }, { "start_pos": 397, "end_pos": 397, "sequence_org": "L", "sequence_mut": "A", "comment": "Abolishes VHLE3-dependent ubiquitination; when associated with A-400.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "11566883", "url": "https://pubmed.ncbi.nlm.nih.gov/11566883" } ], "uniprot_canonical_ac": "Q16665-1" }, { "start_pos": 400, "end_pos": 400, "sequence_org": "L", "sequence_mut": "A", "comment": "Abolishes VHLE3-dependent ubiquitination; when associated with A-397.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "11566883", "url": "https://pubmed.ncbi.nlm.nih.gov/11566883" } ], "uniprot_canonical_ac": "Q16665-1" }, { "start_pos": 402, "end_pos": 402, "sequence_org": "P", "sequence_mut": "A", "comment": "Abolishes in VHLE3-dependent ubiquitination, abolishes oxygen-dependent regulation of VP16, partially reduced VHLE target site ubiquitination and no interaction with VHL. No VHLE target site ubiquitination; when associated with G-564. Increases HIF1A instability and reduces HIF1A-induced target gene transcriptional activation; when associated with A-564.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "24681946", "url": "https://pubmed.ncbi.nlm.nih.gov/24681946" }, { "database": "PubMed", "id": "11566883", "url": "https://pubmed.ncbi.nlm.nih.gov/11566883" }, { "database": "PubMed", "id": "16862177", "url": "https://pubmed.ncbi.nlm.nih.gov/16862177" } ], "uniprot_canonical_ac": "Q16665-1" }, { "start_pos": 564, "end_pos": 564, "sequence_org": "P", "sequence_mut": "A", "comment": "Increases HIF1A instability and reduces HIF1A-induced target gene transcriptional activation; when associated with A-402.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "24681946", "url": "https://pubmed.ncbi.nlm.nih.gov/24681946" }, { "database": "PubMed", "id": "11566883", "url": "https://pubmed.ncbi.nlm.nih.gov/11566883" }, { "database": "PubMed", "id": "16862177", "url": "https://pubmed.ncbi.nlm.nih.gov/16862177" } ], "uniprot_canonical_ac": "Q16665-1" }, { "start_pos": 564, "end_pos": 564, "sequence_org": "P", "sequence_mut": "G", "comment": "No change in VHL-dependent ubiquitination. Partially reduced VHLE target site ubiquitination. No VHLE target site ubiquitination; when associated with A-402.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "24681946", "url": "https://pubmed.ncbi.nlm.nih.gov/24681946" }, { "database": "PubMed", "id": "11566883", "url": "https://pubmed.ncbi.nlm.nih.gov/11566883" }, { "database": "PubMed", "id": "16862177", "url": "https://pubmed.ncbi.nlm.nih.gov/16862177" } ], "uniprot_canonical_ac": "Q16665-1" } ], "record_id": "pubmed.11566883", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation.", "journal": "Molecular and cellular biology", "date": "2001", "authors": "Wu G, Lyapina S, Das I, Li J, Gurney M, Pauley A, Chui I, Deshaies RJ, Kitajewski J", "reference": { "type": "PubMed", "id": "11585921", "url": "https://pubmed.ncbi.nlm.nih.gov/11585921" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y618-1", "protein_name": "Nuclear receptor corepressor 2", "gene_name": "NCOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13616-1", "protein_name": "Cullin-1", "gene_name": "CUL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13547-1", "protein_name": "Histone deacetylase 1", "gene_name": "HDAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5TA89-1", "protein_name": "Transcription factor HES-5", "gene_name": "HES5", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60907-1", "protein_name": "F-box-like/WD repeat-containing protein TBL1X", "gene_name": "TBL1X", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46531-1", "protein_name": "Neurogenic locus notch homolog protein 1", "gene_name": "NOTCH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06330-1", "protein_name": "Recombining binding protein suppressor of hairless", "gene_name": "RBPJ", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BZK7-1", "protein_name": "F-box-like/WD repeat-containing protein TBL1XR1", "gene_name": "TBL1XR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBN7-1", "protein_name": "Protein deacetylase HDAC6", "gene_name": "HDAC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q969H0-1", "protein_name": "F-box/WD repeat-containing protein 7", "gene_name": "FBXW7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IZL2-1", "protein_name": "Mastermind-like protein 2", "gene_name": "MAML2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92830-1", "protein_name": "Histone acetyltransferase KAT2A", "gene_name": "KAT2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62877-1", "protein_name": "E3 ubiquitin-protein ligase RBX1", "gene_name": "RBX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96JK9-1", "protein_name": "Mastermind-like protein 3", "gene_name": "MAML3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15379-1", "protein_name": "Histone deacetylase 3", "gene_name": "HDAC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WUI4-1", "protein_name": "Histone deacetylase 7", "gene_name": "HDAC7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQL6-1", "protein_name": "Histone deacetylase 5", "gene_name": "HDAC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UKV0-1", "protein_name": "Histone deacetylase 9", "gene_name": "HDAC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92769-1", "protein_name": "Histone deacetylase 2", "gene_name": "HDAC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01106-2", "protein_name": "Myc proto-oncogene protein", "gene_name": "MYC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96DB2-1", "protein_name": "Histone deacetylase 11", "gene_name": "HDAC11", "tax_name": 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"protein_name": "Cyclin-dependent kinase 8", "gene_name": "CDK8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04725-1", "protein_name": "Transducin-like enhancer protein 2", "gene_name": "TLE2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75376-1", "protein_name": "Nuclear receptor corepressor 1", "gene_name": "NCOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13573-1", "protein_name": "SNW domain-containing protein 1", "gene_name": "SNW1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5J3-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 1", "gene_name": "HEY1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY41-1", "protein_name": "Histone deacetylase 8", "gene_name": "HDAC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14469-1", "protein_name": "Transcription factor HES-1", "gene_name": "HES1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13495-1", "protein_name": "Mastermind-like domain-containing protein 1", "gene_name": "MAMLD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92585-1", "protein_name": "Mastermind-like protein 1", "gene_name": "MAML1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04727-1", "protein_name": "Transducin-like enhancer protein 4", "gene_name": "TLE4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56524-1", "protein_name": "Histone deacetylase 4", "gene_name": "HDAC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63208-1", "protein_name": "S-phase kinase-associated protein 1", "gene_name": "SKP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11585921", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 47 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": 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[] } ] }, { "title": "Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch.", "journal": "Science (New York, N.Y.)", "date": "2002", "authors": "Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML", "reference": { "type": "PubMed", "id": "11823643", "url": "https://pubmed.ncbi.nlm.nih.gov/11823643" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NWT6-1", "protein_name": "Hypoxia-inducible factor 1-alpha inhibitor", "gene_name": "HIF1AN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P97481-1", "protein_name": "Endothelial PAS domain-containing protein 1", "gene_name": "Epas1", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q99814-1", "protein_name": "Endothelial PAS domain-containing protein 1", "gene_name": "EPAS1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11823643", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2002", "authors": "Dames SA, Martinez-Yamout M, De Guzman RN, Dyson HJ, Wright PE", "reference": { "type": "PubMed", "id": "11959977", "url": "https://pubmed.ncbi.nlm.nih.gov/11959977" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27540-1", "protein_name": "Aryl hydrocarbon receptor nuclear translocator", "gene_name": "ARNT", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99967-1", "protein_name": "Cbp/p300-interacting transactivator 2", "gene_name": "CITED2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99814-1", "protein_name": "Endothelial PAS domain-containing protein 1", "gene_name": "EPAS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16790-1", "protein_name": "Carbonic anhydrase 9", "gene_name": "CA9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y241-1", "protein_name": "HIG1 domain family member 1A, mitochondrial", "gene_name": "HIGD1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15692-13", "protein_name": "Vascular endothelial growth factor A, long form", "gene_name": "VEGFA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01588-1", "protein_name": "Erythropoietin", "gene_name": "EPO", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11959977", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 10 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2002", "authors": "Freedman SJ, Sun ZY, Poy F, Kung AL, Livingston DM, Wagner G, Eck MJ", "reference": { "type": "PubMed", "id": "11959990", "url": "https://pubmed.ncbi.nlm.nih.gov/11959990" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27540-1", "protein_name": "Aryl hydrocarbon receptor nuclear translocator", "gene_name": "ARNT", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NWT6-1", "protein_name": "Hypoxia-inducible factor 1-alpha inhibitor", "gene_name": "HIF1AN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99967-1", "protein_name": "Cbp/p300-interacting transactivator 2", "gene_name": "CITED2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99814-1", 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Ivan Mircea, Gertler Frank, Kaelin William G, Pavletich Nikola P", "reference": { "type": "PubMed", "id": "12004076", "url": "https://pubmed.ncbi.nlm.nih.gov/12004076" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15369-1", "protein_name": "Elongin-C", "gene_name": "ELOC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15370-1", "protein_name": "Elongin-B", "gene_name": "ELOB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P40337-1", "protein_name": "von Hippel-Lindau disease tumor suppressor", "gene_name": "VHL", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": 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KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford RW, Elkins JM, Oldham NJ, Bhattacharya S, Gleadle JM, Ratcliffe PJ, Pugh CW, Schofield CJ", "reference": { "type": "PubMed", "id": "12042299", "url": "https://pubmed.ncbi.nlm.nih.gov/12042299" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NWT6-1", "protein_name": "Hypoxia-inducible factor 1-alpha inhibitor", "gene_name": "HIF1AN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99814-1", "protein_name": "Endothelial PAS domain-containing protein 1", "gene_name": "EPAS1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], 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"tax_name": "Human" }, { "uniprot_canonical_ac": "P78504-1", "protein_name": "Protein jagged-1", "gene_name": "JAG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IZL2-1", "protein_name": "Mastermind-like protein 2", "gene_name": "MAML2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76050-1", "protein_name": "E3 ubiquitin-protein ligase NEURL1", "gene_name": "NEURL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92830-1", "protein_name": "Histone acetyltransferase KAT2A", "gene_name": "KAT2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62877-1", "protein_name": "E3 ubiquitin-protein ligase RBX1", "gene_name": "RBX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86YT6-1", "protein_name": "E3 ubiquitin-protein ligase MIB1", "gene_name": "MIB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96JK9-1", "protein_name": "Mastermind-like protein 3", "gene_name": "MAML3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00548-1", "protein_name": 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"uniprot_canonical_ac": "Q92769-1", "protein_name": "Histone deacetylase 2", "gene_name": "HDAC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01106-2", "protein_name": "Myc proto-oncogene protein", "gene_name": "MYC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96DB2-1", "protein_name": "Histone deacetylase 11", "gene_name": "HDAC11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04724-1", "protein_name": "Transducin-like enhancer protein 1", "gene_name": "TLE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ87-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif-like protein", "gene_name": "HEYL", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q969S8-1", "protein_name": "Polyamine deacetylase HDAC10", "gene_name": "HDAC10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBP5-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 2", "gene_name": "HEY2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFP9-1", "protein_name": "Neurobeachin", "gene_name": "NBEA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92831-1", "protein_name": "Histone acetyltransferase KAT2B", "gene_name": "KAT2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24863-1", "protein_name": "Cyclin-C", "gene_name": "CCNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49336-1", "protein_name": "Cyclin-dependent kinase 8", "gene_name": "CDK8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04725-1", "protein_name": "Transducin-like enhancer protein 2", "gene_name": "TLE2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75376-1", "protein_name": "Nuclear receptor corepressor 1", "gene_name": "NCOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13573-1", "protein_name": "SNW domain-containing protein 1", "gene_name": "SNW1", "tax_name": "Human" }, { 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"https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.12050117", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 65 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], 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"o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.", "journal": "Nature", "date": "2002", "authors": "Hon Wai-Ching, Wilson Michael I, Harlos Karl, Claridge Timothy D W, Schofield Christopher J, Pugh Christopher W, Maxwell Patrick H, Ratcliffe Peter J, Stuart David I, Jones E Yvonne", "reference": { "type": "PubMed", "id": "12050673", "url": "https://pubmed.ncbi.nlm.nih.gov/12050673" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15369-1", "protein_name": "Elongin-C", "gene_name": "ELOC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15370-1", "protein_name": "Elongin-B", "gene_name": "ELOB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P40337-1", "protein_name": "von Hippel-Lindau disease tumor suppressor", "gene_name": "VHL", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.12050673", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor.", "journal": "Genes & development", "date": "2002", "authors": "Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK", "reference": { "type": "PubMed", "id": "12080085", "url": "https://pubmed.ncbi.nlm.nih.gov/12080085" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NWT6-1", "protein_name": "Hypoxia-inducible factor 1-alpha inhibitor", "gene_name": "HIF1AN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P97481-1", "protein_name": "Endothelial PAS domain-containing protein 1", "gene_name": "Epas1", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q99814-1", "protein_name": "Endothelial PAS domain-containing protein 1", "gene_name": "EPAS1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 199, "end_pos": 199, "sequence_org": "H", "sequence_mut": "A", "comment": "Prevents suppression of HIFCAD activity. Strongly stimulates 2-oxoglutarate turnover. No stimulation of 2-oxoglutarate turnover; when associated with R-340.", "evidence": [ { "database": "UniProtKB", "id": "Q9NWT6", "url": "https://www.uniprot.org/uniprotkb/Q9NWT6" }, { "database": "PubMed", "id": "12080085", "url": "https://pubmed.ncbi.nlm.nih.gov/12080085" } ], "uniprot_canonical_ac": "Q9NWT6-1" }, { "start_pos": 201, "end_pos": 201, "sequence_org": "D", "sequence_mut": "A", "comment": "Prevents suppression of HIFCAD activity.", "evidence": [ { "database": "UniProtKB", "id": "Q9NWT6", "url": "https://www.uniprot.org/uniprotkb/Q9NWT6" }, { "database": "PubMed", "id": "18611856", "url": "https://pubmed.ncbi.nlm.nih.gov/18611856" }, { "database": "PubMed", "id": "21177872", "url": "https://pubmed.ncbi.nlm.nih.gov/21177872" }, { "database": "PubMed", "id": "12080085", "url": "https://pubmed.ncbi.nlm.nih.gov/12080085" } ], "uniprot_canonical_ac": "Q9NWT6-1" }, { "start_pos": 201, "end_pos": 201, "sequence_org": "D", "sequence_mut": "E", "comment": "Loss of HIF1AAsn hydroxylation activity. Slightly stimulates 2-oxoglutarate turnover.", "evidence": [ { "database": "UniProtKB", "id": "Q9NWT6", "url": "https://www.uniprot.org/uniprotkb/Q9NWT6" }, { "database": "PubMed", "id": "18611856", "url": "https://pubmed.ncbi.nlm.nih.gov/18611856" }, { "database": "PubMed", "id": "12080085", "url": "https://pubmed.ncbi.nlm.nih.gov/12080085" }, { "database": "PubMed", "id": "21177872", "url": "https://pubmed.ncbi.nlm.nih.gov/21177872" } ], "uniprot_canonical_ac": "Q9NWT6-1" }, { "start_pos": 201, "end_pos": 201, "sequence_org": "D", "sequence_mut": "G", "comment": "No impact on HIF1AAsn hydroxylation activity. Loss of Asp hydroxylation ability. Strongly stimulates 2-oxoglutarate turnover. Loss of HIF1AAsn hydroxylation activity and slight stimulation of 2-oxoglutarate turnover; when associated with R-296.", "evidence": [ { "database": "UniProtKB", "id": "Q9NWT6", "url": "https://www.uniprot.org/uniprotkb/Q9NWT6" }, { "database": "PubMed", "id": "18611856", "url": "https://pubmed.ncbi.nlm.nih.gov/18611856" }, { "database": "PubMed", "id": "21177872", "url": "https://pubmed.ncbi.nlm.nih.gov/21177872" }, { "database": "PubMed", "id": "12080085", "url": "https://pubmed.ncbi.nlm.nih.gov/12080085" } ], "uniprot_canonical_ac": "Q9NWT6-1" }, { "start_pos": 530, "end_pos": 530, "sequence_org": "P", "sequence_mut": "A", "comment": "Confers transcriptional activity at normoxia; when associated with A-851.", "evidence": [ { "database": "UniProtKB", "id": "P97481", "url": "https://www.uniprot.org/uniprotkb/P97481" }, { "database": "PubMed", "id": "12080085", "url": "https://pubmed.ncbi.nlm.nih.gov/12080085" } ], "uniprot_canonical_ac": "P97481-1" }, { "start_pos": 851, "end_pos": 851, "sequence_org": "N", "sequence_mut": "A", "comment": "Confers transcriptional activity at normoxia; when associated with A-530.", "evidence": [ { "database": "UniProtKB", "id": "P97481", "url": "https://www.uniprot.org/uniprotkb/P97481" }, { "database": "PubMed", "id": "12080085", "url": "https://pubmed.ncbi.nlm.nih.gov/12080085" } ], "uniprot_canonical_ac": "P97481-1" } ], "record_id": "pubmed.12080085", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro.", "journal": "Molecular and cellular biology", "date": "2002", "authors": "Wallberg AE, Pedersen K, Lendahl U, Roeder RG", "reference": { "type": "PubMed", "id": "12391150", "url": "https://pubmed.ncbi.nlm.nih.gov/12391150" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y618-1", "protein_name": "Nuclear receptor corepressor 2", "gene_name": "NCOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P78536-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 17", "gene_name": "ADAM17", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92542-1", "protein_name": "Nicastrin", "gene_name": "NCSTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96BI3-1", "protein_name": "Gamma-secretase subunit APH-1A", "gene_name": "APH1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13616-1", "protein_name": "Cullin-1", "gene_name": "CUL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13547-1", "protein_name": "Histone deacetylase 1", "gene_name": "HDAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NR61-1", "protein_name": "Delta-like protein 4", "gene_name": "DLL4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NZ42-1", "protein_name": "Gamma-secretase subunit PEN-2", "gene_name": "PSENEN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5TA89-1", "protein_name": "Transcription factor HES-5", "gene_name": "HES5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96AX9-1", "protein_name": "E3 ubiquitin-protein ligase MIB2", "gene_name": "MIB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "A8MQ27-1", "protein_name": "E3 ubiquitin-protein ligase NEURL1B", "gene_name": "NEURL1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60907-1", "protein_name": "F-box-like/WD repeat-containing protein TBL1X", "gene_name": "TBL1X", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46531-1", "protein_name": "Neurogenic locus notch homolog protein 1", "gene_name": "NOTCH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06330-1", "protein_name": "Recombining binding protein suppressor of hairless", "gene_name": "RBPJ", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BZK7-1", "protein_name": "F-box-like/WD repeat-containing protein TBL1XR1", "gene_name": "TBL1XR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBN7-1", "protein_name": "Protein deacetylase HDAC6", "gene_name": "HDAC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P78504-1", "protein_name": "Protein jagged-1", "gene_name": "JAG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IZL2-1", "protein_name": "Mastermind-like protein 2", "gene_name": "MAML2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76050-1", "protein_name": "E3 ubiquitin-protein ligase NEURL1", "gene_name": "NEURL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92830-1", "protein_name": "Histone acetyltransferase KAT2A", "gene_name": "KAT2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62877-1", "protein_name": "E3 ubiquitin-protein ligase RBX1", "gene_name": "RBX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86YT6-1", "protein_name": "E3 ubiquitin-protein ligase MIB1", "gene_name": "MIB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96JK9-1", "protein_name": "Mastermind-like protein 3", "gene_name": "MAML3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00548-1", "protein_name": "Delta-like protein 1", "gene_name": "DLL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15379-1", "protein_name": "Histone deacetylase 3", "gene_name": "HDAC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WUI4-1", "protein_name": "Histone deacetylase 7", "gene_name": "HDAC7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQL6-1", "protein_name": "Histone deacetylase 5", "gene_name": "HDAC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WW43-1", "protein_name": "Gamma-secretase subunit APH-1B", "gene_name": "APH1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UKV0-1", "protein_name": "Histone deacetylase 9", "gene_name": "HDAC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92769-1", "protein_name": "Histone deacetylase 2", "gene_name": "HDAC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01106-2", "protein_name": "Myc proto-oncogene protein", "gene_name": "MYC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96DB2-1", "protein_name": "Histone deacetylase 11", "gene_name": "HDAC11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04724-1", "protein_name": "Transducin-like enhancer protein 1", "gene_name": "TLE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ87-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif-like protein", "gene_name": "HEYL", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q969S8-1", "protein_name": "Polyamine deacetylase HDAC10", "gene_name": "HDAC10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBP5-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 2", "gene_name": "HEY2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFP9-1", "protein_name": "Neurobeachin", "gene_name": "NBEA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92831-1", "protein_name": "Histone acetyltransferase KAT2B", "gene_name": "KAT2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24863-1", "protein_name": "Cyclin-C", "gene_name": "CCNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49336-1", "protein_name": "Cyclin-dependent kinase 8", "gene_name": "CDK8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04725-1", "protein_name": "Transducin-like enhancer protein 2", "gene_name": "TLE2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75376-1", "protein_name": "Nuclear receptor corepressor 1", "gene_name": "NCOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13573-1", "protein_name": "SNW domain-containing protein 1", "gene_name": "SNW1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49810-1", "protein_name": "Presenilin-2", "gene_name": "PSEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5J3-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 1", "gene_name": "HEY1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y219-1", "protein_name": "Protein jagged-2", "gene_name": "JAG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY41-1", "protein_name": "Histone deacetylase 8", "gene_name": "HDAC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14469-1", "protein_name": "Transcription factor HES-1", "gene_name": "HES1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13495-1", "protein_name": "Mastermind-like domain-containing protein 1", "gene_name": "MAMLD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92585-1", "protein_name": "Mastermind-like protein 1", "gene_name": "MAML1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04727-1", "protein_name": "Transducin-like enhancer protein 4", "gene_name": "TLE4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49768-1", "protein_name": "Presenilin-1", "gene_name": "PSEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14672-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56524-1", "protein_name": "Histone deacetylase 4", "gene_name": "HDAC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63208-1", "protein_name": "S-phase kinase-associated protein 1", "gene_name": "SKP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.12391150", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 62 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { 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"glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.", "journal": "J. Biol. Chem.", "date": "2003", "authors": "Elkins JM, Hewitson KS, McNeill LA, Seibel JF, Schlemminger I, Pugh CW, Ratcliffe PJ, Schofield CJ", "reference": { "type": "PubMed", "id": "12446723", "url": "https://pubmed.ncbi.nlm.nih.gov/12446723" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NWT6-1", "protein_name": "Hypoxia-inducible factor 1-alpha inhibitor", "gene_name": "HIF1AN", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.12446723", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { 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hypoxia-inducible factor-1alpha by CITED2.", "journal": "Nature structural biology", "date": "2003", "authors": "Freedman SJ, Sun ZY, Kung AL, France DS, Wagner G, Eck MJ", "reference": { "type": "PubMed", "id": "12778114", "url": "https://pubmed.ncbi.nlm.nih.gov/12778114" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99967-1", "protein_name": "Cbp/p300-interacting transactivator 2", "gene_name": "CITED2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], 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"Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16790-1", "protein_name": "Carbonic anhydrase 9", "gene_name": "CA9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y241-1", "protein_name": "HIG1 domain family member 1A, mitochondrial", "gene_name": "HIGD1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15692-13", "protein_name": "Vascular endothelial growth factor A, long form", "gene_name": "VEGFA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01588-1", "protein_name": "Erythropoietin", "gene_name": "EPO", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.15184875", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], 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"total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity.", "journal": "The Biochemical journal", "date": "2004", "authors": "Lancaster DE, McNeill LA, McDonough MA, Aplin RT, Hewitson KS, Pugh CW, Ratcliffe PJ, Schofield CJ", "reference": { "type": "PubMed", "id": "15239670", "url": "https://pubmed.ncbi.nlm.nih.gov/15239670" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NWT6-1", "protein_name": "Hypoxia-inducible factor 1-alpha inhibitor", "gene_name": "HIF1AN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99814-1", "protein_name": "Endothelial PAS domain-containing protein 1", "gene_name": "EPAS1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 340, "end_pos": 340, "sequence_org": "L", "sequence_mut": "R", "comment": "Impairs dimer formation, leading to loss of HIF1AAsn hydroxylation activity. No stimulation of 2-oxoglutarate turnover; when associated with A-201.", "evidence": [ { "database": "UniProtKB", "id": "Q9NWT6", "url": "https://www.uniprot.org/uniprotkb/Q9NWT6" }, { "database": "PubMed", "id": "15239670", "url": "https://pubmed.ncbi.nlm.nih.gov/15239670" }, { "database": "PubMed", "id": "18611856", "url": "https://pubmed.ncbi.nlm.nih.gov/18611856" } ], "uniprot_canonical_ac": "Q9NWT6-1" }, { "start_pos": 344, "end_pos": 344, "sequence_org": "I", "sequence_mut": "R", "comment": "No effect on dimer formation and HIF1AAsn hydroxylation activity.", "evidence": [ { "database": "UniProtKB", "id": "Q9NWT6", "url": "https://www.uniprot.org/uniprotkb/Q9NWT6" }, { "database": "PubMed", "id": "15239670", "url": "https://pubmed.ncbi.nlm.nih.gov/15239670" } ], "uniprot_canonical_ac": "Q9NWT6-1" } ], "record_id": "pubmed.15239670", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Sumoylation increases HIF-1alpha stability and its transcriptional activity.", "journal": "Biochemical and biophysical research communications", "date": "2004", "authors": "Bae SH, Jeong JW, Park JA, Kim SH, Bae MK, Choi SJ, Kim KW", "reference": { "type": "PubMed", "id": "15465032", "url": "https://pubmed.ncbi.nlm.nih.gov/15465032" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 389, "end_pos": 389, "sequence_org": "K", "sequence_mut": "R", "comment": "No change in sumoylation.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "15465032", "url": "https://pubmed.ncbi.nlm.nih.gov/15465032" } ], "uniprot_canonical_ac": "Q16665-1" }, { "start_pos": 391, "end_pos": 391, "sequence_org": "K", "sequence_mut": "R", "comment": "Abolishes 1 sumoylation. Abolishes 1 sumoylation; when associated with R-532. Abolishes 2 sumoylations; when associated with R-477. No change in HIF1A protein turnover rate but increased transcriptional activity; when associated with R-377; R-477 and R-532.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "17610843", "url": "https://pubmed.ncbi.nlm.nih.gov/17610843" }, { "database": "PubMed", "id": "15465032", "url": "https://pubmed.ncbi.nlm.nih.gov/15465032" } ], "uniprot_canonical_ac": "Q16665-1" }, { "start_pos": 392, "end_pos": 392, "sequence_org": "K", "sequence_mut": "R", "comment": "No change in sumoylation.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "15465032", "url": "https://pubmed.ncbi.nlm.nih.gov/15465032" } ], "uniprot_canonical_ac": "Q16665-1" }, { "start_pos": 442, "end_pos": 442, "sequence_org": "K", "sequence_mut": "R", "comment": "No change in sumoylation.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "15465032", "url": "https://pubmed.ncbi.nlm.nih.gov/15465032" } ], "uniprot_canonical_ac": "Q16665-1" }, { "start_pos": 460, "end_pos": 460, "sequence_org": "K", "sequence_mut": "R", "comment": "No change in sumoylation nor in ARD1-mediated acetylation.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "15465032", "url": "https://pubmed.ncbi.nlm.nih.gov/15465032" } ], "uniprot_canonical_ac": "Q16665-1" }, { "start_pos": 477, "end_pos": 477, "sequence_org": "K", "sequence_mut": "R", "comment": "Abolishes 1 sumoylation. Abolishes 2 sumoylations; when associated with R-391. No change in HIF1A protein turnover rate but increased transcriptional activity; when associated with R-377; R-391 and R-532.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "17610843", "url": "https://pubmed.ncbi.nlm.nih.gov/17610843" }, { "database": "PubMed", "id": "15465032", "url": "https://pubmed.ncbi.nlm.nih.gov/15465032" } ], "uniprot_canonical_ac": "Q16665-1" }, { "start_pos": 532, "end_pos": 532, "sequence_org": "K", "sequence_mut": "R", "comment": "Reduced ubiquitination. No change in sumoylation nor on interaction with NAA10. No change in HIF1A protein turnover rate but increased transcriptional activity; when associated with R-377; R-391 and R-477. Complete loss of ubiquitination, but no change in VHL binding; when associated with K-538 and K-547.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "16288748", "url": "https://pubmed.ncbi.nlm.nih.gov/16288748" }, { "database": "PubMed", "id": "17610843", "url": "https://pubmed.ncbi.nlm.nih.gov/17610843" }, { "database": "PubMed", "id": "10944113", "url": "https://pubmed.ncbi.nlm.nih.gov/10944113" }, { "database": "PubMed", "id": "16862177", "url": "https://pubmed.ncbi.nlm.nih.gov/16862177" }, { "database": "PubMed", "id": "15465032", "url": "https://pubmed.ncbi.nlm.nih.gov/15465032" } ], "uniprot_canonical_ac": "Q16665-1" }, { "start_pos": 538, "end_pos": 538, "sequence_org": "K", "sequence_mut": "R", "comment": "No change in sumoylation, but reduced ubiquitination. Complete loss of ubiquitination, but no change in VHL binding; when associated with K-532 and K-547.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "10944113", "url": "https://pubmed.ncbi.nlm.nih.gov/10944113" }, { "database": "PubMed", "id": "16862177", "url": "https://pubmed.ncbi.nlm.nih.gov/16862177" }, { "database": "PubMed", "id": "15465032", "url": "https://pubmed.ncbi.nlm.nih.gov/15465032" } ], "uniprot_canonical_ac": "Q16665-1" }, { "start_pos": 547, "end_pos": 547, "sequence_org": "K", "sequence_mut": "R", "comment": "No change in sumoylation, but reduced ubiquitination. Complete loss of ubiquitination, but no change in VHL binding; when associated with K-532 and K-538.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "10944113", "url": "https://pubmed.ncbi.nlm.nih.gov/10944113" }, { "database": "PubMed", "id": "16862177", "url": "https://pubmed.ncbi.nlm.nih.gov/16862177" }, { "database": "PubMed", "id": "15465032", "url": "https://pubmed.ncbi.nlm.nih.gov/15465032" } ], "uniprot_canonical_ac": "Q16665-1" } ], "record_id": "pubmed.15465032", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": 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"count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Identification of hypoxia-inducible factor-1alpha (HIF-1alpha) polymorphism as a mutation in prostate cancer that prevents normoxia-induced degradation.", "journal": "The Prostate", "date": "2005", "authors": "Fu XS, Choi E, Bubley GJ, Balk SP", "reference": { "type": "PubMed", "id": "15538748", "url": "https://pubmed.ncbi.nlm.nih.gov/15538748" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.15538748", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.", "journal": "Molecular cell", "date": "2004", "authors": "Fryer CJ, White JB, Jones KA", "reference": { "type": "PubMed", "id": "15546612", "url": "https://pubmed.ncbi.nlm.nih.gov/15546612" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y618-1", "protein_name": "Nuclear receptor corepressor 2", "gene_name": "NCOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P78536-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 17", "gene_name": "ADAM17", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92542-1", "protein_name": "Nicastrin", "gene_name": "NCSTN", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"Human" }, { "uniprot_canonical_ac": "Q04721-1", "protein_name": "Neurogenic locus notch homolog protein 2", "gene_name": "NOTCH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96AX9-1", "protein_name": "E3 ubiquitin-protein ligase MIB2", "gene_name": "MIB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "A8MQ27-1", "protein_name": "E3 ubiquitin-protein ligase NEURL1B", "gene_name": "NEURL1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60907-1", "protein_name": "F-box-like/WD repeat-containing protein TBL1X", "gene_name": "TBL1X", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46531-1", "protein_name": "Neurogenic locus notch homolog protein 1", "gene_name": "NOTCH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06330-1", "protein_name": "Recombining binding protein suppressor of hairless", "gene_name": "RBPJ", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BZK7-1", "protein_name": "F-box-like/WD repeat-containing protein TBL1XR1", "gene_name": 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"protein_name": "Mastermind-like protein 3", "gene_name": "MAML3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00548-1", "protein_name": "Delta-like protein 1", "gene_name": "DLL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15379-1", "protein_name": "Histone deacetylase 3", "gene_name": "HDAC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WUI4-1", "protein_name": "Histone deacetylase 7", "gene_name": "HDAC7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQL6-1", "protein_name": "Histone deacetylase 5", "gene_name": "HDAC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WW43-1", "protein_name": "Gamma-secretase subunit APH-1B", "gene_name": "APH1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UKV0-1", "protein_name": "Histone deacetylase 9", "gene_name": "HDAC9", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"Hairy/enhancer-of-split related with YRPW motif protein 2", "gene_name": "HEY2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFP9-1", "protein_name": "Neurobeachin", "gene_name": "NBEA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92831-1", "protein_name": "Histone acetyltransferase KAT2B", "gene_name": "KAT2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24863-1", "protein_name": "Cyclin-C", "gene_name": "CCNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49336-1", "protein_name": "Cyclin-dependent kinase 8", "gene_name": "CDK8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04725-1", "protein_name": "Transducin-like enhancer protein 2", "gene_name": "TLE2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75376-1", "protein_name": "Nuclear receptor corepressor 1", "gene_name": "NCOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13573-1", "protein_name": "SNW domain-containing protein 1", "gene_name": "SNW1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49810-1", "protein_name": "Presenilin-2", "gene_name": "PSEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5J3-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 1", "gene_name": "HEY1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y219-1", "protein_name": "Protein jagged-2", "gene_name": "JAG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY41-1", "protein_name": "Histone deacetylase 8", "gene_name": "HDAC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14469-1", "protein_name": "Transcription factor HES-1", "gene_name": "HES1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13495-1", "protein_name": "Mastermind-like domain-containing protein 1", "gene_name": "MAMLD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92585-1", "protein_name": "Mastermind-like protein 1", "gene_name": "MAML1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04727-1", "protein_name": "Transducin-like enhancer protein 4", "gene_name": "TLE4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49768-1", "protein_name": "Presenilin-1", "gene_name": "PSEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14672-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56524-1", "protein_name": "Histone deacetylase 4", "gene_name": "HDAC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63208-1", "protein_name": "S-phase kinase-associated protein 1", "gene_name": "SKP1", "tax_name": "Human" } ], "species": [ { "name": 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"count": 0 } ], "sort_fields": [] } ] }, { "title": "Stat3 dimerization regulated by reversible acetylation of a single lysine residue.", "journal": "Science (New York, N.Y.)", "date": "2005", "authors": "Yuan ZL, Guan YJ, Chatterjee D, Chin YE", "reference": { "type": "PubMed", "id": "15653507", "url": "https://pubmed.ncbi.nlm.nih.gov/15653507" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P26358-1", "protein_name": "DNA (cytosine-5)-methyltransferase 1", "gene_name": "DNMT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13547-1", "protein_name": "Histone deacetylase 1", "gene_name": "HDAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31785-1", "protein_name": "Cytokine receptor common subunit gamma", "gene_name": "IL2RG", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75626-1", "protein_name": "PR 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"url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 685, "end_pos": 685, "sequence_org": "K", "sequence_mut": "R", "comment": "Decreased acetylation by EP300/p300, leading to impaired homodimerization and activation.", "evidence": [ { "database": "UniProtKB", "id": "P40763", "url": "https://www.uniprot.org/uniprotkb/P40763" }, { "database": "PubMed", "id": "15653507", "url": "https://pubmed.ncbi.nlm.nih.gov/15653507" } ], "uniprot_canonical_ac": "P40763-1" } ], "record_id": "pubmed.15653507", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 11 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 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"count": 0 } ], "sort_fields": [] } ] }, { "title": "Somatic VHL alteration and its impact on prognosis in patients with clear cell renal cell carcinoma.", "journal": "Oncology reports", "date": "2005", "authors": "Kim JH, Jung CW, Cho YH, Lee J, Lee SH, Kim HY, Park J, Park JO, Kim K, Kim WS, Park YS, Im YH, Kang WK, Park K", "reference": { "type": "PubMed", "id": "15809750", "url": "https://pubmed.ncbi.nlm.nih.gov/15809750" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.15809750", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": 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"P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63208-1", "protein_name": "S-phase kinase-associated protein 1", "gene_name": "SKP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.16256737", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 46 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": 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], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 532, "end_pos": 532, "sequence_org": "K", "sequence_mut": "R", "comment": "Reduced ubiquitination. No change in sumoylation nor on interaction with NAA10. No change in HIF1A protein turnover rate but increased transcriptional activity; when associated with R-377; R-391 and R-477. Complete loss of ubiquitination, but no change in VHL binding; when associated with K-538 and K-547.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "16288748", "url": "https://pubmed.ncbi.nlm.nih.gov/16288748" }, { "database": "PubMed", "id": "17610843", "url": "https://pubmed.ncbi.nlm.nih.gov/17610843" }, { "database": "PubMed", "id": "10944113", "url": "https://pubmed.ncbi.nlm.nih.gov/10944113" }, { "database": "PubMed", "id": "16862177", "url": "https://pubmed.ncbi.nlm.nih.gov/16862177" }, { "database": "PubMed", "id": "15465032", "url": "https://pubmed.ncbi.nlm.nih.gov/15465032" } ], "uniprot_canonical_ac": "Q16665-1" } ], "record_id": "pubmed.16288748", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", 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"o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.", "journal": "Cell", "date": "2006", "authors": "Nam Y, Sliz P, Song L, Aster JC, Blacklow SC", "reference": { "type": "PubMed", "id": "16530044", "url": "https://pubmed.ncbi.nlm.nih.gov/16530044" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y618-1", "protein_name": "Nuclear receptor corepressor 2", "gene_name": "NCOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P78536-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 17", "gene_name": "ADAM17", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92542-1", "protein_name": "Nicastrin", "gene_name": "NCSTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96BI3-1", "protein_name": "Gamma-secretase subunit APH-1A", "gene_name": "APH1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13616-1", "protein_name": "Cullin-1", "gene_name": "CUL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13547-1", "protein_name": "Histone deacetylase 1", "gene_name": "HDAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NR61-1", "protein_name": "Delta-like protein 4", "gene_name": "DLL4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NZ42-1", "protein_name": "Gamma-secretase subunit PEN-2", "gene_name": "PSENEN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5TA89-1", "protein_name": "Transcription factor HES-5", "gene_name": "HES5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96AX9-1", "protein_name": "E3 ubiquitin-protein ligase MIB2", "gene_name": "MIB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "A8MQ27-1", "protein_name": "E3 ubiquitin-protein ligase NEURL1B", "gene_name": "NEURL1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60907-1", "protein_name": "F-box-like/WD repeat-containing protein TBL1X", "gene_name": "TBL1X", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46531-1", "protein_name": "Neurogenic locus notch homolog protein 1", "gene_name": "NOTCH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06330-1", "protein_name": "Recombining binding protein suppressor of hairless", "gene_name": "RBPJ", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BZK7-1", "protein_name": "F-box-like/WD repeat-containing protein TBL1XR1", "gene_name": "TBL1XR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBN7-1", "protein_name": "Protein deacetylase HDAC6", "gene_name": "HDAC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P78504-1", "protein_name": "Protein jagged-1", "gene_name": "JAG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IZL2-1", "protein_name": "Mastermind-like protein 2", "gene_name": "MAML2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76050-1", "protein_name": "E3 ubiquitin-protein ligase NEURL1", "gene_name": "NEURL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92830-1", "protein_name": "Histone acetyltransferase KAT2A", "gene_name": "KAT2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62877-1", "protein_name": "E3 ubiquitin-protein ligase RBX1", "gene_name": "RBX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86YT6-1", "protein_name": "E3 ubiquitin-protein ligase MIB1", "gene_name": "MIB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96JK9-1", "protein_name": "Mastermind-like protein 3", "gene_name": "MAML3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00548-1", "protein_name": "Delta-like protein 1", "gene_name": "DLL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15379-1", "protein_name": "Histone deacetylase 3", "gene_name": "HDAC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WUI4-1", "protein_name": "Histone deacetylase 7", "gene_name": "HDAC7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQL6-1", "protein_name": "Histone deacetylase 5", "gene_name": "HDAC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WW43-1", "protein_name": "Gamma-secretase subunit APH-1B", "gene_name": "APH1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UKV0-1", "protein_name": "Histone deacetylase 9", "gene_name": "HDAC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92769-1", "protein_name": "Histone deacetylase 2", "gene_name": "HDAC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01106-2", "protein_name": "Myc proto-oncogene protein", "gene_name": "MYC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96DB2-1", "protein_name": "Histone deacetylase 11", "gene_name": "HDAC11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04724-1", "protein_name": "Transducin-like enhancer protein 1", "gene_name": "TLE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ87-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif-like protein", "gene_name": "HEYL", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q969S8-1", "protein_name": "Polyamine deacetylase HDAC10", "gene_name": "HDAC10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBP5-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 2", "gene_name": "HEY2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFP9-1", "protein_name": "Neurobeachin", "gene_name": "NBEA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92831-1", "protein_name": "Histone acetyltransferase KAT2B", "gene_name": "KAT2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24863-1", "protein_name": "Cyclin-C", "gene_name": "CCNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49336-1", "protein_name": "Cyclin-dependent kinase 8", "gene_name": "CDK8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04725-1", "protein_name": "Transducin-like enhancer protein 2", "gene_name": "TLE2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75376-1", "protein_name": "Nuclear receptor corepressor 1", "gene_name": "NCOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13573-1", "protein_name": "SNW domain-containing protein 1", "gene_name": "SNW1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49810-1", "protein_name": "Presenilin-2", "gene_name": "PSEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5J3-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 1", "gene_name": "HEY1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y219-1", "protein_name": "Protein jagged-2", "gene_name": "JAG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY41-1", "protein_name": "Histone deacetylase 8", "gene_name": "HDAC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14469-1", "protein_name": "Transcription factor HES-1", "gene_name": "HES1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13495-1", "protein_name": "Mastermind-like domain-containing protein 1", "gene_name": "MAMLD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92585-1", "protein_name": "Mastermind-like protein 1", "gene_name": "MAML1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04727-1", "protein_name": "Transducin-like enhancer protein 4", "gene_name": "TLE4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49768-1", "protein_name": "Presenilin-1", "gene_name": "PSEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14672-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56524-1", "protein_name": "Histone deacetylase 4", "gene_name": "HDAC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63208-1", "protein_name": "S-phase kinase-associated protein 1", "gene_name": "SKP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.16530044", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 62 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Fath DM, Kong X, Liang D, Lin Z, Chou A, Jiang Y, Fang J, Caro J, Sang N", "reference": { "type": "PubMed", "id": "16543236", "url": "https://pubmed.ncbi.nlm.nih.gov/16543236" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 803, "end_pos": 803, "sequence_org": "N", "sequence_mut": "A", "comment": "Recruits CREBBP. No enhancement of CREBBP by Clioquinol in the presence of FIH1. No change in nuclear location nor on repression of transcriptional activity in the presence of histone deacetylase inhibitor.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "16543236", "url": "https://pubmed.ncbi.nlm.nih.gov/16543236" }, { "database": "PubMed", "id": "16973622", "url": "https://pubmed.ncbi.nlm.nih.gov/16973622" } ], "uniprot_canonical_ac": "Q16665-1" } ], "record_id": "pubmed.16543236", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "HIF-1alpha and EPAS ubiquitination mediated by the VHL tumour suppressor involves flexibility in the ubiquitination mechanism, similar to other RING E3 ligases.", "journal": "Oncogene", "date": "2007", "authors": "Paltoglou S, Roberts BJ", "reference": { "type": "PubMed", "id": "16862177", "url": "https://pubmed.ncbi.nlm.nih.gov/16862177" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 402, "end_pos": 402, "sequence_org": "P", "sequence_mut": "A", "comment": "Abolishes in VHLE3-dependent ubiquitination, abolishes oxygen-dependent regulation of VP16, partially reduced VHLE target site ubiquitination and no interaction with VHL. No VHLE target site ubiquitination; when associated with G-564. Increases HIF1A instability and reduces HIF1A-induced target gene transcriptional activation; when associated with A-564.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "24681946", "url": "https://pubmed.ncbi.nlm.nih.gov/24681946" }, { "database": "PubMed", "id": "11566883", "url": "https://pubmed.ncbi.nlm.nih.gov/11566883" }, { "database": "PubMed", "id": "16862177", "url": "https://pubmed.ncbi.nlm.nih.gov/16862177" } ], "uniprot_canonical_ac": "Q16665-1" }, { "start_pos": 532, "end_pos": 532, "sequence_org": "K", "sequence_mut": "R", "comment": "Reduced ubiquitination. No change in sumoylation nor on interaction with NAA10. No change in HIF1A protein turnover rate but increased transcriptional activity; when associated with R-377; R-391 and R-477. Complete loss of ubiquitination, but no change in VHL binding; when associated with K-538 and K-547.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "16288748", "url": "https://pubmed.ncbi.nlm.nih.gov/16288748" }, { "database": "PubMed", "id": "17610843", "url": "https://pubmed.ncbi.nlm.nih.gov/17610843" }, { "database": "PubMed", "id": "10944113", "url": "https://pubmed.ncbi.nlm.nih.gov/10944113" }, { "database": "PubMed", "id": "16862177", "url": "https://pubmed.ncbi.nlm.nih.gov/16862177" }, { "database": "PubMed", "id": "15465032", "url": "https://pubmed.ncbi.nlm.nih.gov/15465032" } ], "uniprot_canonical_ac": "Q16665-1" }, { "start_pos": 538, "end_pos": 538, "sequence_org": "K", "sequence_mut": "R", "comment": "No change in sumoylation, but reduced ubiquitination. Complete loss of ubiquitination, but no change in VHL binding; when associated with K-532 and K-547.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "10944113", "url": "https://pubmed.ncbi.nlm.nih.gov/10944113" }, { "database": "PubMed", "id": "16862177", "url": "https://pubmed.ncbi.nlm.nih.gov/16862177" }, { "database": "PubMed", "id": "15465032", "url": "https://pubmed.ncbi.nlm.nih.gov/15465032" } ], "uniprot_canonical_ac": "Q16665-1" }, { "start_pos": 547, "end_pos": 547, "sequence_org": "K", "sequence_mut": "R", "comment": "No change in sumoylation, but reduced ubiquitination. Complete loss of ubiquitination, but no change in VHL binding; when associated with K-532 and K-538.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "10944113", "url": "https://pubmed.ncbi.nlm.nih.gov/10944113" }, { "database": "PubMed", "id": "16862177", "url": "https://pubmed.ncbi.nlm.nih.gov/16862177" }, { "database": "PubMed", "id": "15465032", "url": "https://pubmed.ncbi.nlm.nih.gov/15465032" } ], "uniprot_canonical_ac": "Q16665-1" }, { "start_pos": 564, "end_pos": 564, "sequence_org": "P", "sequence_mut": "A", "comment": "Increases HIF1A instability and reduces HIF1A-induced target gene transcriptional activation; when associated with A-402.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "24681946", "url": "https://pubmed.ncbi.nlm.nih.gov/24681946" }, { "database": "PubMed", "id": "11566883", "url": "https://pubmed.ncbi.nlm.nih.gov/11566883" }, { "database": "PubMed", "id": "16862177", "url": "https://pubmed.ncbi.nlm.nih.gov/16862177" } ], "uniprot_canonical_ac": "Q16665-1" }, { "start_pos": 564, "end_pos": 564, "sequence_org": "P", "sequence_mut": "G", "comment": "No change in VHL-dependent ubiquitination. Partially reduced VHLE target site ubiquitination. No VHLE target site ubiquitination; when associated with A-402.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "24681946", "url": "https://pubmed.ncbi.nlm.nih.gov/24681946" }, { "database": "PubMed", "id": "11566883", "url": "https://pubmed.ncbi.nlm.nih.gov/11566883" }, { "database": "PubMed", "id": "16862177", "url": "https://pubmed.ncbi.nlm.nih.gov/16862177" } ], "uniprot_canonical_ac": "Q16665-1" } ], "record_id": "pubmed.16862177", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", 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both ubiquitination and asparagine hydroxylation of hypoxia-inducible factor-1alpha, leading to expression of vascular endothelial growth factor and erythropoietin in normoxic cells.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Choi SM, Choi KO, Park YK, Cho H, Yang EG, Park H", "reference": { "type": "PubMed", "id": "16973622", "url": "https://pubmed.ncbi.nlm.nih.gov/16973622" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 803, "end_pos": 803, "sequence_org": "N", "sequence_mut": "A", "comment": "Recruits CREBBP. No enhancement of CREBBP by Clioquinol in the presence of FIH1. No change in nuclear location nor on repression of transcriptional activity in the presence of histone deacetylase inhibitor.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "16543236", "url": "https://pubmed.ncbi.nlm.nih.gov/16543236" }, { "database": "PubMed", "id": "16973622", "url": "https://pubmed.ncbi.nlm.nih.gov/16973622" } ], "uniprot_canonical_ac": "Q16665-1" } ], "record_id": "pubmed.16973622", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": 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"count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": 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"uniprot_canonical_ac": "Q9NZ42-1", "protein_name": "Gamma-secretase subunit PEN-2", "gene_name": "PSENEN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5TA89-1", "protein_name": "Transcription factor HES-5", "gene_name": "HES5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96AX9-1", "protein_name": "E3 ubiquitin-protein ligase MIB2", "gene_name": "MIB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "A8MQ27-1", "protein_name": "E3 ubiquitin-protein ligase NEURL1B", "gene_name": "NEURL1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60907-1", "protein_name": "F-box-like/WD repeat-containing protein TBL1X", "gene_name": "TBL1X", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46531-1", "protein_name": "Neurogenic locus notch homolog protein 1", "gene_name": "NOTCH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06330-1", "protein_name": "Recombining binding protein suppressor of hairless", "gene_name": "RBPJ", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BZK7-1", "protein_name": "F-box-like/WD repeat-containing protein TBL1XR1", "gene_name": "TBL1XR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBN7-1", "protein_name": "Protein deacetylase HDAC6", "gene_name": "HDAC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P78504-1", "protein_name": "Protein jagged-1", "gene_name": "JAG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IZL2-1", "protein_name": "Mastermind-like protein 2", "gene_name": "MAML2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76050-1", "protein_name": "E3 ubiquitin-protein ligase NEURL1", "gene_name": "NEURL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92830-1", "protein_name": "Histone acetyltransferase KAT2A", "gene_name": "KAT2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62877-1", "protein_name": "E3 ubiquitin-protein ligase RBX1", "gene_name": "RBX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86YT6-1", "protein_name": "E3 ubiquitin-protein ligase MIB1", "gene_name": "MIB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96JK9-1", "protein_name": "Mastermind-like protein 3", "gene_name": "MAML3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00548-1", "protein_name": "Delta-like protein 1", "gene_name": "DLL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15379-1", "protein_name": "Histone deacetylase 3", "gene_name": "HDAC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WUI4-1", "protein_name": "Histone deacetylase 7", "gene_name": "HDAC7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQL6-1", "protein_name": "Histone deacetylase 5", "gene_name": "HDAC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WW43-1", "protein_name": "Gamma-secretase subunit APH-1B", "gene_name": "APH1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UKV0-1", "protein_name": "Histone deacetylase 9", "gene_name": "HDAC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92769-1", "protein_name": "Histone deacetylase 2", "gene_name": "HDAC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01106-2", "protein_name": "Myc proto-oncogene protein", "gene_name": "MYC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96DB2-1", "protein_name": "Histone deacetylase 11", "gene_name": "HDAC11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04724-1", "protein_name": "Transducin-like enhancer protein 1", "gene_name": "TLE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ87-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif-like protein", "gene_name": "HEYL", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q969S8-1", "protein_name": "Polyamine deacetylase HDAC10", "gene_name": "HDAC10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBP5-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 2", "gene_name": "HEY2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFP9-1", "protein_name": "Neurobeachin", "gene_name": "NBEA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92831-1", "protein_name": "Histone acetyltransferase KAT2B", "gene_name": "KAT2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24863-1", "protein_name": "Cyclin-C", "gene_name": "CCNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49336-1", "protein_name": "Cyclin-dependent kinase 8", "gene_name": "CDK8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04725-1", "protein_name": "Transducin-like enhancer protein 2", "gene_name": "TLE2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75376-1", "protein_name": "Nuclear receptor corepressor 1", "gene_name": "NCOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13573-1", "protein_name": "SNW domain-containing protein 1", "gene_name": "SNW1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49810-1", "protein_name": "Presenilin-2", "gene_name": "PSEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5J3-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 1", "gene_name": "HEY1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y219-1", "protein_name": "Protein jagged-2", "gene_name": "JAG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY41-1", "protein_name": "Histone deacetylase 8", "gene_name": "HDAC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14469-1", "protein_name": "Transcription factor HES-1", "gene_name": "HES1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13495-1", "protein_name": "Mastermind-like domain-containing protein 1", "gene_name": "MAMLD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92585-1", "protein_name": "Mastermind-like protein 1", "gene_name": "MAML1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04727-1", "protein_name": "Transducin-like enhancer protein 4", "gene_name": "TLE4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49768-1", "protein_name": "Presenilin-1", "gene_name": "PSEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14672-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56524-1", "protein_name": "Histone deacetylase 4", "gene_name": "HDAC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63208-1", "protein_name": "S-phase kinase-associated protein 1", "gene_name": "SKP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.17114293", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 62 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha.", "journal": "Mol. Cell", "date": "2007", "authors": "Liu Ye V, Baek Jin H, Zhang Huafeng, Diez Roberto, Cole Robert N, Semenza Gregg L", "reference": { "type": "PubMed", "id": "17244529", "url": "https://pubmed.ncbi.nlm.nih.gov/17244529" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63244-1", "protein_name": "Small ribosomal subunit protein RACK1", "gene_name": "RACK1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.17244529", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Modulation of p300 binding by posttranslational modifications of the C-terminal activation domain of hypoxia-inducible factor-1alpha.", "journal": "FEBS letters", "date": "2007", "authors": "Cho H, Ahn DR, Park H, Yang EG", "reference": { "type": "PubMed", "id": "17382325", "url": "https://pubmed.ncbi.nlm.nih.gov/17382325" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "phosphorylation": [ { "start_pos": 796, "end_pos": 796, "kinase_uniprot_canonical_ac": "P68400-1", "kinase_gene_name": "CSNK2A1", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q16665", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q16665" }, { "database": "PubMed", "id": "17382325", "url": "https://pubmed.ncbi.nlm.nih.gov/17382325" } ], "site_lbl": "Thr796", "uniprot_canonical_ac": "Q16665-1" } ], "record_id": "pubmed.17382325", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl", "uniprot_canonical_ac" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "SUMOylation of hypoxia-inducible factor-1alpha reduces its transcriptional activity.", "journal": "Biochemical and biophysical research communications", "date": "2007", "authors": "Berta MA, Mazure N, Hattab M, Pouyssegur J, Brahimi-Horn MC", "reference": { "type": "PubMed", "id": "17610843", "url": "https://pubmed.ncbi.nlm.nih.gov/17610843" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 377, "end_pos": 377, "sequence_org": "K", "sequence_mut": "R", "comment": "No change in HIF1A protein turnover rate but increased transcriptional activity; when associated with R-391; R-477 and R-532.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "17610843", "url": "https://pubmed.ncbi.nlm.nih.gov/17610843" } ], "uniprot_canonical_ac": "Q16665-1" }, { "start_pos": 391, "end_pos": 391, "sequence_org": "K", "sequence_mut": "R", "comment": "Abolishes 1 sumoylation. Abolishes 1 sumoylation; when associated with R-532. Abolishes 2 sumoylations; when associated with R-477. No change in HIF1A protein turnover rate but increased transcriptional activity; when associated with R-377; R-477 and R-532.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "17610843", "url": "https://pubmed.ncbi.nlm.nih.gov/17610843" }, { "database": "PubMed", "id": "15465032", "url": "https://pubmed.ncbi.nlm.nih.gov/15465032" } ], "uniprot_canonical_ac": "Q16665-1" }, { "start_pos": 477, "end_pos": 477, "sequence_org": "K", "sequence_mut": "R", "comment": "Abolishes 1 sumoylation. Abolishes 2 sumoylations; when associated with R-391. No change in HIF1A protein turnover rate but increased transcriptional activity; when associated with R-377; R-391 and R-532.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "17610843", "url": "https://pubmed.ncbi.nlm.nih.gov/17610843" }, { "database": "PubMed", "id": "15465032", "url": "https://pubmed.ncbi.nlm.nih.gov/15465032" } ], "uniprot_canonical_ac": "Q16665-1" }, { "start_pos": 532, "end_pos": 532, "sequence_org": "K", "sequence_mut": "R", "comment": "Reduced ubiquitination. No change in sumoylation nor on interaction with NAA10. No change in HIF1A protein turnover rate but increased transcriptional activity; when associated with R-377; R-391 and R-477. Complete loss of ubiquitination, but no change in VHL binding; when associated with K-538 and K-547.", "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" }, { "database": "PubMed", "id": "16288748", "url": "https://pubmed.ncbi.nlm.nih.gov/16288748" }, { "database": "PubMed", "id": "17610843", "url": "https://pubmed.ncbi.nlm.nih.gov/17610843" }, { "database": "PubMed", "id": "10944113", "url": "https://pubmed.ncbi.nlm.nih.gov/10944113" }, { "database": "PubMed", "id": "16862177", "url": "https://pubmed.ncbi.nlm.nih.gov/16862177" }, { "database": "PubMed", "id": "15465032", "url": "https://pubmed.ncbi.nlm.nih.gov/15465032" } ], "uniprot_canonical_ac": "Q16665-1" } ], "record_id": "pubmed.17610843", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Hypoxia-inducible factor-1alpha (HIF-1alpha) gene polymorphisms, circulating insulin-like growth factor binding protein (IGFBP)-3 levels and prostate cancer.", "journal": "The Prostate", "date": "2007", "authors": "Li H, Bubley GJ, Balk SP, Gaziano JM, Pollak M, Stampfer MJ, Ma J", "reference": { "type": "PubMed", "id": "17624927", "url": "https://pubmed.ncbi.nlm.nih.gov/17624927" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.17624927", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha.", "journal": "Molecular biology of the cell", "date": "2007", "authors": "Hu CJ, Sataur A, Wang L, Chen H, Simon MC", "reference": { "type": "PubMed", "id": "17804822", "url": "https://pubmed.ncbi.nlm.nih.gov/17804822" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27540-1", "protein_name": "Aryl hydrocarbon receptor nuclear translocator", "gene_name": "ARNT", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99967-1", "protein_name": "Cbp/p300-interacting transactivator 2", "gene_name": "CITED2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99814-1", "protein_name": "Endothelial PAS domain-containing protein 1", "gene_name": "EPAS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16790-1", "protein_name": "Carbonic anhydrase 9", "gene_name": "CA9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y241-1", "protein_name": "HIG1 domain family member 1A, mitochondrial", "gene_name": "HIGD1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15692-13", "protein_name": "Vascular endothelial growth factor A, long form", "gene_name": "VEGFA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01588-1", "protein_name": "Erythropoietin", "gene_name": "EPO", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.17804822", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 10 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia.", "journal": "Cell", "date": "2007", "authors": "Carbia-Nagashima A, Gerez J, Perez-Castro C, Paez-Pereda M, Silberstein S, Stalla GK, Holsboer F, Arzt E", "reference": { "type": "PubMed", "id": "17956732", "url": "https://pubmed.ncbi.nlm.nih.gov/17956732" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P25963-1", "protein_name": "NF-kappa-B inhibitor alpha", "gene_name": "NFKBIA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0C7N0-1", "protein_name": "RWD domain-containing protein 3", "gene_name": "Rwdd3", "tax_name": "Rat" }, { "uniprot_canonical_ac": "Q9Y3V2-1", "protein_name": "RWD domain-containing protein 3", "gene_name": "RWDD3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63279-1", "protein_name": "SUMO-conjugating enzyme UBC9", "gene_name": "UBE2I", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63165-1", "protein_name": "Small ubiquitin-related modifier 1", "gene_name": "SUMO1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 21, "end_pos": 21, "sequence_org": "K", "sequence_mut": "R", "comment": "Little change in Tax-stimulated transactivation. No sumoylation. Greatly reduced Tax- or cytokine-stimulated transactivation and decrease in ubiquitination and degradation; when associated with R-22. Does not affect activation by FK506.", "evidence": [ { "database": "UniProtKB", "id": "P25963", "url": "https://www.uniprot.org/uniprotkb/P25963" }, { "database": "PubMed", "id": "7479976", "url": "https://pubmed.ncbi.nlm.nih.gov/7479976" }, { "database": "PubMed", "id": "17956732", "url": "https://pubmed.ncbi.nlm.nih.gov/17956732" }, { "database": "PubMed", "id": "8657102", "url": "https://pubmed.ncbi.nlm.nih.gov/8657102" }, { "database": "PubMed", "id": "11124955", "url": "https://pubmed.ncbi.nlm.nih.gov/11124955" } ], "uniprot_canonical_ac": "P25963-1" }, { "start_pos": 22, "end_pos": 22, "sequence_org": "K", "sequence_mut": "R", "comment": "Little change in Tax-stimulated transactivation. No sumoylation. Greatly reduced Tax- or cytokine-stimulated transactivation and decrease in ubiquitination and degradation; when associated with R-21. Does not affect activation by FK506.", "evidence": [ { "database": "UniProtKB", "id": "P25963", "url": "https://www.uniprot.org/uniprotkb/P25963" }, { "database": "PubMed", "id": "7479976", "url": "https://pubmed.ncbi.nlm.nih.gov/7479976" }, { "database": "PubMed", "id": "17956732", "url": "https://pubmed.ncbi.nlm.nih.gov/17956732" }, { "database": "PubMed", "id": "8657102", "url": "https://pubmed.ncbi.nlm.nih.gov/8657102" }, { "database": "PubMed", "id": "11124955", "url": "https://pubmed.ncbi.nlm.nih.gov/11124955" } ], "uniprot_canonical_ac": "P25963-1" }, { "start_pos": 61, "end_pos": 62, "sequence_org": "YP", "sequence_mut": "AA", "comment": "Abolishes enhancement of NFKBIA and NR3C1 sumoylation. No effect on NR3C1 transcriptional activity.", "evidence": [ { "database": "UniProtKB", "id": "Q9Y3V2", "url": "https://www.uniprot.org/uniprotkb/Q9Y3V2" }, { "database": "PubMed", "id": "17956732", "url": "https://pubmed.ncbi.nlm.nih.gov/17956732" }, { "database": "PubMed", "id": "23508108", "url": "https://pubmed.ncbi.nlm.nih.gov/23508108" } ], "uniprot_canonical_ac": "Q9Y3V2-1" } ], "record_id": "pubmed.17956732", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 6 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation.", "journal": "Nature reviews. Cancer", "date": "2008", "authors": "Welcker M, Clurman BE", "reference": { "type": "PubMed", "id": "18094723", "url": "https://pubmed.ncbi.nlm.nih.gov/18094723" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y618-1", "protein_name": "Nuclear receptor corepressor 2", "gene_name": "NCOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13616-1", "protein_name": "Cullin-1", "gene_name": "CUL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13547-1", "protein_name": "Histone deacetylase 1", "gene_name": "HDAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5TA89-1", "protein_name": "Transcription factor HES-5", "gene_name": "HES5", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60907-1", "protein_name": "F-box-like/WD repeat-containing protein TBL1X", "gene_name": "TBL1X", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46531-1", "protein_name": "Neurogenic locus notch homolog protein 1", "gene_name": "NOTCH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06330-1", "protein_name": "Recombining binding protein suppressor of hairless", "gene_name": "RBPJ", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BZK7-1", "protein_name": "F-box-like/WD repeat-containing protein TBL1XR1", "gene_name": "TBL1XR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBN7-1", "protein_name": "Protein deacetylase HDAC6", "gene_name": "HDAC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IZL2-1", "protein_name": "Mastermind-like protein 2", "gene_name": "MAML2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92830-1", "protein_name": "Histone acetyltransferase KAT2A", "gene_name": "KAT2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62877-1", "protein_name": "E3 ubiquitin-protein ligase RBX1", "gene_name": "RBX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96JK9-1", "protein_name": "Mastermind-like protein 3", "gene_name": "MAML3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15379-1", "protein_name": "Histone deacetylase 3", "gene_name": "HDAC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WUI4-1", "protein_name": "Histone deacetylase 7", "gene_name": "HDAC7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UQL6-1", "protein_name": "Histone deacetylase 5", "gene_name": "HDAC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UKV0-1", "protein_name": "Histone deacetylase 9", "gene_name": "HDAC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62979-1", "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92769-1", "protein_name": "Histone deacetylase 2", "gene_name": "HDAC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01106-2", "protein_name": "Myc proto-oncogene protein", "gene_name": "MYC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96DB2-1", "protein_name": "Histone deacetylase 11", "gene_name": "HDAC11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04724-1", "protein_name": "Transducin-like enhancer protein 1", "gene_name": "TLE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ87-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif-like protein", "gene_name": "HEYL", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q969S8-1", "protein_name": "Polyamine deacetylase HDAC10", "gene_name": "HDAC10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBP5-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 2", "gene_name": "HEY2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFP9-1", "protein_name": "Neurobeachin", "gene_name": "NBEA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92831-1", "protein_name": "Histone acetyltransferase KAT2B", "gene_name": "KAT2B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P24863-1", "protein_name": "Cyclin-C", "gene_name": "CCNC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49336-1", "protein_name": "Cyclin-dependent kinase 8", "gene_name": "CDK8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04725-1", "protein_name": "Transducin-like enhancer protein 2", "gene_name": "TLE2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75376-1", "protein_name": "Nuclear receptor corepressor 1", "gene_name": "NCOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13573-1", "protein_name": "SNW domain-containing protein 1", "gene_name": "SNW1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5J3-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 1", "gene_name": "HEY1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY41-1", "protein_name": "Histone deacetylase 8", "gene_name": "HDAC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14469-1", "protein_name": "Transcription factor HES-1", "gene_name": "HES1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13495-1", "protein_name": "Mastermind-like domain-containing protein 1", "gene_name": "MAMLD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92585-1", "protein_name": "Mastermind-like protein 1", "gene_name": "MAML1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04727-1", "protein_name": "Transducin-like enhancer protein 4", "gene_name": "TLE4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56524-1", "protein_name": "Histone deacetylase 4", "gene_name": "HDAC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63208-1", "protein_name": "S-phase kinase-associated protein 1", "gene_name": "SKP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.18094723", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 46 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Rare variant of hypoxia-inducible factor-1alpha (HIF-1A) and breast cancer risk in Korean women.", "journal": "Clinica chimica acta; international journal of clinical chemistry", "date": "2008", "authors": "Lee JY, Choi JY, Lee KM, Park SK, Han SH, Noh DY, Ahn SH, Kim DH, Hong YC, Ha E, Yoo KY, Ambrosone CB, Kang D", "reference": { "type": "PubMed", "id": "18160046", "url": "https://pubmed.ncbi.nlm.nih.gov/18160046" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.18160046", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Nuclear translocation of hypoxia-inducible factors (HIFs): involvement of the classical importin alpha/beta pathway.", "journal": "Biochimica et biophysica acta", "date": "2008", "authors": "Depping R, Steinhoff A, Schindler SG, Friedrich B, Fagerlund R, Metzen E, Hartmann E, Kohler M", "reference": { "type": "PubMed", "id": "18187047", "url": "https://pubmed.ncbi.nlm.nih.gov/18187047" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27540-1", "protein_name": "Aryl hydrocarbon receptor nuclear translocator", "gene_name": "ARNT", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99967-1", "protein_name": "Cbp/p300-interacting transactivator 2", "gene_name": "CITED2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99814-1", "protein_name": "Endothelial PAS domain-containing protein 1", "gene_name": "EPAS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16790-1", "protein_name": "Carbonic anhydrase 9", "gene_name": "CA9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y241-1", "protein_name": "HIG1 domain family member 1A, mitochondrial", "gene_name": "HIGD1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15692-13", "protein_name": "Vascular endothelial growth factor A, long form", "gene_name": "VEGFA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01588-1", "protein_name": "Erythropoietin", "gene_name": "EPO", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.18187047", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 10 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints.", "journal": "Molecular cell", "date": "2008", "authors": "Perissi V, Scafoglio C, Zhang J, Ohgi KA, Rose DW, Glass CK, Rosenfeld MG", "reference": { "type": "PubMed", "id": "18374649", "url": "https://pubmed.ncbi.nlm.nih.gov/18374649" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y618-1", "protein_name": "Nuclear receptor corepressor 2", "gene_name": "NCOR2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P78536-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 17", "gene_name": "ADAM17", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92542-1", "protein_name": "Nicastrin", "gene_name": "NCSTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96BI3-1", "protein_name": "Gamma-secretase subunit APH-1A", "gene_name": "APH1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13616-1", "protein_name": "Cullin-1", "gene_name": "CUL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13547-1", "protein_name": "Histone deacetylase 1", "gene_name": "HDAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NR61-1", "protein_name": "Delta-like protein 4", "gene_name": "DLL4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NZ42-1", "protein_name": "Gamma-secretase subunit PEN-2", "gene_name": "PSENEN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q5TA89-1", "protein_name": "Transcription factor HES-5", "gene_name": "HES5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96AX9-1", "protein_name": "E3 ubiquitin-protein ligase MIB2", "gene_name": "MIB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "A8MQ27-1", "protein_name": "E3 ubiquitin-protein ligase NEURL1B", "gene_name": "NEURL1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60907-1", "protein_name": "F-box-like/WD repeat-containing protein TBL1X", "gene_name": "TBL1X", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46531-1", "protein_name": "Neurogenic locus notch homolog protein 1", "gene_name": "NOTCH1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q06330-1", "protein_name": "Recombining binding protein suppressor of hairless", "gene_name": "RBPJ", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BZK7-1", "protein_name": "F-box-like/WD repeat-containing protein TBL1XR1", "gene_name": "TBL1XR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBN7-1", "protein_name": "Protein deacetylase HDAC6", "gene_name": "HDAC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P78504-1", "protein_name": "Protein jagged-1", "gene_name": "JAG1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IZL2-1", "protein_name": "Mastermind-like protein 2", "gene_name": "MAML2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O76050-1", "protein_name": "E3 ubiquitin-protein ligase NEURL1", "gene_name": "NEURL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92830-1", "protein_name": "Histone acetyltransferase KAT2A", "gene_name": "KAT2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62877-1", "protein_name": "E3 ubiquitin-protein ligase RBX1", "gene_name": "RBX1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86YT6-1", "protein_name": "E3 ubiquitin-protein ligase MIB1", "gene_name": "MIB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96JK9-1", "protein_name": "Mastermind-like protein 3", "gene_name": "MAML3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00548-1", "protein_name": "Delta-like protein 1", "gene_name": "DLL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15379-1", "protein_name": "Histone deacetylase 3", "gene_name": "HDAC3", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"tax_name": "Human" }, { "uniprot_canonical_ac": "Q96DB2-1", "protein_name": "Histone deacetylase 11", "gene_name": "HDAC11", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04724-1", "protein_name": "Transducin-like enhancer protein 1", "gene_name": "TLE1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQ87-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif-like protein", "gene_name": "HEYL", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q969S8-1", "protein_name": "Polyamine deacetylase HDAC10", "gene_name": "HDAC10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBP5-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 2", "gene_name": "HEY2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8NFP9-1", "protein_name": "Neurobeachin", "gene_name": "NBEA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92831-1", "protein_name": "Histone acetyltransferase KAT2B", "gene_name": "KAT2B", "tax_name": "Human" }, { 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"tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5J3-1", "protein_name": "Hairy/enhancer-of-split related with YRPW motif protein 1", "gene_name": "HEY1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y219-1", "protein_name": "Protein jagged-2", "gene_name": "JAG2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY41-1", "protein_name": "Histone deacetylase 8", "gene_name": "HDAC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14469-1", "protein_name": "Transcription factor HES-1", "gene_name": "HES1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13495-1", "protein_name": "Mastermind-like domain-containing protein 1", "gene_name": "MAMLD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92585-1", "protein_name": "Mastermind-like protein 1", "gene_name": "MAML1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04727-1", "protein_name": "Transducin-like enhancer protein 4", "gene_name": "TLE4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49768-1", "protein_name": "Presenilin-1", "gene_name": "PSEN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O14672-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56524-1", "protein_name": "Histone deacetylase 4", "gene_name": "HDAC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63208-1", "protein_name": "S-phase kinase-associated protein 1", "gene_name": "SKP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "phosphorylation": [ { "start_pos": 123, "end_pos": 123, "kinase_uniprot_canonical_ac": "Q05655-1", 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"field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl", "uniprot_canonical_ac" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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Immunol.", "date": "2008", "authors": "Lukashev Dmitriy, Sitkovsky Michail", "reference": { "type": "PubMed", "id": "18638657", "url": "https://pubmed.ncbi.nlm.nih.gov/18638657" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.18638657", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": 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Sci.", "date": "2008", "authors": "Yee Koh Mei, Spivak-Kroizman Taly R, Powis Garth", "reference": { "type": "PubMed", "id": "18809331", "url": "https://pubmed.ncbi.nlm.nih.gov/18809331" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.18809331", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": 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"glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The C1772T genetic polymorphism in human HIF-1alpha gene associates with expression of HIF-1alpha protein in breast cancer.", "journal": "Oncology reports", "date": "2008", "authors": "Kim HO, Jo YH, Lee J, Lee SS, Yoon KS", "reference": { "type": "PubMed", "id": "18949419", "url": "https://pubmed.ncbi.nlm.nih.gov/18949419" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" } ], "species": [ { "name": "Homo 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[] } ] }, { "title": "Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth.", "journal": "Biochim. Biophys. Acta", "date": "2009", "authors": "Nardinocchi Lavinia, Puca Rosa, Guidolin Diego, Belloni Anna S, Bossi Gianluca, Michiels Carine, Sacchi Ada, Onisto Maurizio, D'Orazi Gabriella", "reference": { "type": "PubMed", "id": "19046997", "url": "https://pubmed.ncbi.nlm.nih.gov/19046997" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H2X6-1", "protein_name": "Homeodomain-interacting protein kinase 2", "gene_name": "HIPK2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.19046997", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], 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"gene_name": "EED", "tax_name": "Human" }, { "uniprot_canonical_ac": "P84243-1", "protein_name": "Histone H3.3", "gene_name": "H3-3A; H3-3B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15910-1", "protein_name": "Histone-lysine N-methyltransferase EZH2", "gene_name": "EZH2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NZQ7-1", "protein_name": "Programmed cell death 1 ligand 1", "gene_name": "CD274", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99814-1", "protein_name": "Endothelial PAS domain-containing protein 1", "gene_name": "EPAS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P36402-5", "protein_name": "Transcription factor 7", "gene_name": "TCF7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UJU2-1", "protein_name": "Lymphoid enhancer-binding factor 1", "gene_name": "LEF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NQB0-1", "protein_name": "Transcription factor 7-like 2", "gene_name": "TCF7L2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P10914-1", "protein_name": "Interferon regulatory factor 1", "gene_name": "IRF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16236-1", "protein_name": "Nuclear factor erythroid 2-related factor 2", "gene_name": "NFE2L2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96ST3-1", "protein_name": "Paired amphipathic helix protein Sin3a", "gene_name": "SIN3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09028-1", "protein_name": "Histone-binding protein RBBP4", "gene_name": "RBBP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00653-1", "protein_name": "Nuclear factor NF-kappa-B p100 subunit", "gene_name": "NFKB2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35222-1", "protein_name": "Catenin beta-1", "gene_name": "CTNNB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15379-1", "protein_name": "Histone deacetylase 3", "gene_name": "HDAC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UBL3-1", "protein_name": "Set1/Ash2 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"P62807-1", "protein_name": "Histone H2B type 1-C/E/F/G/I", "gene_name": "H2BC10; H2BC4; H2BC6; H2BC7; H2BC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P17535-1", "protein_name": "Transcription factor JunD", "gene_name": "JUND", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q03164-1", "protein_name": "Histone-lysine N-methyltransferase 2A", "gene_name": "KMT2A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P40763-1", "protein_name": "Signal transducer and activator of transcription 3", "gene_name": "STAT3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q71DI3-1", "protein_name": "Histone H3.2", "gene_name": "H3C13; H3C14; H3C15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92769-1", "protein_name": "Histone deacetylase 2", "gene_name": "HDAC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60885-1", "protein_name": "Bromodomain-containing protein 4", "gene_name": "BRD4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01106-2", "protein_name": "Myc proto-oncogene protein", "gene_name": "MYC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P16104-1", "protein_name": "Histone H2AX", "gene_name": "H2AX", "tax_name": "Human" }, { "uniprot_canonical_ac": "P33778-1", "protein_name": "Histone H2B type 1-B", "gene_name": "H2BC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P58876-1", "protein_name": "Histone H2B type 1-D", "gene_name": "H2BC5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96A08-1", "protein_name": "Histone H2B type 1-A", "gene_name": "H2BC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P23527-1", "protein_name": "Histone H2B type 1-O", "gene_name": "H2BC17", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0C5Y9-1", "protein_name": "Histone H2A-Bbd type 1", "gene_name": "H2AB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BTM1-1", "protein_name": "Histone H2A.J", "gene_name": "H2AJ", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60814-1", "protein_name": "Histone H2B type 1-K", "gene_name": "H2BC12", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q93077-1", "protein_name": "Histone H2A type 1-C", "gene_name": "H2AC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q93079-1", "protein_name": "Histone H2B type 1-H", "gene_name": "H2BC9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99879-1", "protein_name": "Histone H2B type 1-M", "gene_name": "H2BC14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HCS4-1", "protein_name": "Transcription factor 7-like 1", "gene_name": "TCF7L1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P28347-1", "protein_name": "Transcriptional enhancer factor TEF-1", "gene_name": "TEAD1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15562-1", "protein_name": "Transcriptional enhancer factor TEF-4", "gene_name": "TEAD2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42224-1", "protein_name": "Signal transducer and activator of transcription 1-alpha/beta", "gene_name": "STAT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15561-1", "protein_name": "Transcriptional enhancer factor TEF-3", "gene_name": "TEAD4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q71UI9-1", "protein_name": "Histone H2A.V", "gene_name": "H2AZ2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04908-1", "protein_name": "Histone H2A type 1-B/E", "gene_name": "H2AC4; H2AC8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06899-1", "protein_name": "Histone H2B type 1-J", "gene_name": "H2BC11", "tax_name": "Human" }, { "uniprot_canonical_ac": "P20671-1", "protein_name": "Histone H2A type 1-D", "gene_name": "H2AC7", "tax_name": "Human" }, { "uniprot_canonical_ac": "P57053-1", "protein_name": "Histone H2B type F-S", "gene_name": "H2BC12L", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16777-1", "protein_name": "Histone H2A type 2-C", "gene_name": "H2AC20", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6FI13-1", "protein_name": "Histone H2A type 2-A", "gene_name": "H2AC18; H2AC19", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N257-1", "protein_name": "Histone H2B type 3-B", "gene_name": "H2BC26", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99877-1", "protein_name": "Histone H2B type 1-N", "gene_name": "H2BC15", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99878-1", "protein_name": "Histone H2A type 1-J", "gene_name": "H2AC14", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99880-1", "protein_name": "Histone H2B type 1-L", "gene_name": "H2BC13", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15022-1", "protein_name": "Polycomb protein SUZ12", "gene_name": "SUZ12", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99594-1", "protein_name": "Transcriptional enhancer factor TEF-5", "gene_name": "TEAD3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01100-1", "protein_name": "Protein c-Fos", "gene_name": "FOS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05412-1", "protein_name": "Transcription factor Jun", "gene_name": "JUN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P46937-1", "protein_name": "Transcriptional coactivator YAP1", "gene_name": "YAP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9GZV5-1", "protein_name": "WW domain-containing transcription regulator protein 1", "gene_name": "WWTR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04206-1", "protein_name": "Transcription factor p65", "gene_name": "RELA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.19088198", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 77 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport.", "journal": "The Journal of cell biology", "date": "2009", "authors": "Li Y, Lim S, Hoffman D, Aspenstrom P, Federoff HJ, Rempe DA", "reference": { "type": "PubMed", "id": "19528298", "url": "https://pubmed.ncbi.nlm.nih.gov/19528298" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8TDB4-1", "protein_name": "Protein MGARP", "gene_name": "MGARP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8VI64-1", "protein_name": "Protein MGARP", "gene_name": "Mgarp", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q8IXI1-1", "protein_name": "Mitochondrial Rho GTPase 2", "gene_name": "RHOT2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IXI2-1", "protein_name": "Mitochondrial Rho GTPase 1", "gene_name": "RHOT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8R2H7-1", "protein_name": "Trafficking kinesin-binding protein 2", "gene_name": "Trak2", "tax_name": "Rat" }, { "uniprot_canonical_ac": "Q9UPV9-1", "protein_name": "Trafficking kinesin-binding protein 1", "gene_name": "TRAK1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.19528298", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 7 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Transport of hypoxia-inducible factor HIF-1alpha into the nucleus involves importins 4 and 7.", "journal": "Biochemical and biophysical research communications", "date": "2009", "authors": "Chachami G, Paraskeva E, Mingot JM, Braliou GG, Gorlich D, Simos G", "reference": { "type": "PubMed", "id": "19788888", "url": "https://pubmed.ncbi.nlm.nih.gov/19788888" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27540-1", "protein_name": "Aryl hydrocarbon receptor nuclear translocator", "gene_name": "ARNT", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99967-1", "protein_name": "Cbp/p300-interacting transactivator 2", "gene_name": "CITED2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99814-1", "protein_name": "Endothelial PAS domain-containing protein 1", "gene_name": "EPAS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16790-1", "protein_name": "Carbonic anhydrase 9", "gene_name": "CA9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y241-1", "protein_name": "HIG1 domain family member 1A, mitochondrial", "gene_name": "HIGD1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15692-13", "protein_name": "Vascular endothelial growth factor A, long form", "gene_name": "VEGFA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01588-1", "protein_name": "Erythropoietin", "gene_name": "EPO", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.19788888", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 10 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Casein kinase 1 regulates human hypoxia-inducible factor HIF-1.", "journal": "Journal of cell science", "date": "2010", "authors": "Kalousi A, Mylonis I, Politou AS, Chachami G, Paraskeva E, Simos G", "reference": { "type": "PubMed", "id": "20699359", "url": "https://pubmed.ncbi.nlm.nih.gov/20699359" }, "referenced_glycans": [], 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"Human" }, { "uniprot_canonical_ac": "P49336-1", "protein_name": "Cyclin-dependent kinase 8", "gene_name": "CDK8", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG47-1", "protein_name": "Polyubiquitin-B", "gene_name": "UBB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q04725-1", "protein_name": "Transducin-like enhancer protein 2", "gene_name": "TLE2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75376-1", "protein_name": "Nuclear receptor corepressor 1", "gene_name": "NCOR1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13573-1", "protein_name": "SNW domain-containing protein 1", "gene_name": "SNW1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62987-1", "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49810-1", "protein_name": "Presenilin-2", "gene_name": "PSEN2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5J3-1", "protein_name": "Hairy/enhancer-of-split 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"uniprot_canonical_ac": "O14672-1", "protein_name": "Disintegrin and metalloproteinase domain-containing protein 10", "gene_name": "ADAM10", "tax_name": "Human" }, { "uniprot_canonical_ac": "P56524-1", "protein_name": "Histone deacetylase 4", "gene_name": "HDAC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P0CG48-1", "protein_name": "Polyubiquitin-C", "gene_name": "UBC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63208-1", "protein_name": "S-phase kinase-associated protein 1", "gene_name": "SKP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.20972443", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 62 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1alpha.", "journal": "Molecular cell", "date": "2010", "authors": "Cam H, Easton JB, High A, Houghton PJ", "reference": { "type": "PubMed", "id": "21095582", "url": "https://pubmed.ncbi.nlm.nih.gov/21095582" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "phosphorylation": [ { "start_pos": 696, "end_pos": 696, "kinase_uniprot_canonical_ac": "Q13315-1", "kinase_gene_name": "ATM", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q16665", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/Q16665" }, { "database": "PubMed", "id": "21095582", "url": "https://pubmed.ncbi.nlm.nih.gov/21095582" } ], "site_lbl": "Ser696", "uniprot_canonical_ac": "Q16665-1" }, { "start_pos": 696, "end_pos": 696, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "Q16665", "url": 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"field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl", "uniprot_canonical_ac" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Oncogenic kinase NPM/ALK induces expression of HIF1alpha mRNA.", "journal": "Oncogene", "date": "2011", "authors": "Marzec M, Liu X, Wong W, Yang Y, Pasha T, Kantekure K, Zhang P, Woetmann A, Cheng M, Odum N, Wasik MA", "reference": { "type": "PubMed", "id": "21102525", "url": "https://pubmed.ncbi.nlm.nih.gov/21102525" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P26358-1", "protein_name": "DNA (cytosine-5)-methyltransferase 1", "gene_name": "DNMT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13547-1", "protein_name": "Histone deacetylase 1", "gene_name": "HDAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31785-1", "protein_name": "Cytokine receptor common subunit gamma", "gene_name": "IL2RG", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75626-1", "protein_name": "PR domain zinc finger protein 1", "gene_name": "PRDM1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NZQ7-1", "protein_name": "Programmed cell death 1 ligand 1", "gene_name": "CD274", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96ST3-1", "protein_name": "Paired amphipathic helix protein Sin3a", "gene_name": "SIN3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15379-1", "protein_name": "Histone deacetylase 3", "gene_name": "HDAC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "P40763-1", "protein_name": "Signal transducer and activator of transcription 3", "gene_name": "STAT3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92769-1", "protein_name": "Histone deacetylase 2", "gene_name": "HDAC2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.21102525", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 11 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Roles of the human hypoxia-inducible factor (HIF)-3alpha variants in the hypoxia response.", "journal": "Cellular and molecular life sciences : CMLS", "date": "2011", "authors": "Heikkila M, Pasanen A, Kivirikko KI, Myllyharju J", "reference": { "type": "PubMed", "id": "21479871", "url": "https://pubmed.ncbi.nlm.nih.gov/21479871" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92793-1", "protein_name": "CREB-binding protein", "gene_name": "CREBBP", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27540-1", "protein_name": "Aryl hydrocarbon receptor nuclear translocator", "gene_name": "ARNT", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99967-1", "protein_name": "Cbp/p300-interacting transactivator 2", "gene_name": "CITED2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99814-1", "protein_name": "Endothelial PAS domain-containing protein 1", "gene_name": "EPAS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16790-1", "protein_name": "Carbonic anhydrase 9", "gene_name": "CA9", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y241-1", "protein_name": "HIG1 domain family member 1A, mitochondrial", "gene_name": "HIGD1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15692-13", "protein_name": "Vascular endothelial growth factor A, long form", "gene_name": "VEGFA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01588-1", "protein_name": "Erythropoietin", "gene_name": "EPO", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.21479871", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 10 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { 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"glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2011", "authors": "Zhang Q, Wang HY, Liu X, Bhutani G, Kantekure K, Wasik M", "reference": { "type": "PubMed", "id": "21715655", "url": "https://pubmed.ncbi.nlm.nih.gov/21715655" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HCK5-1", "protein_name": "Protein argonaute-4", "gene_name": "AGO4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06400-1", "protein_name": "Retinoblastoma-associated protein", "gene_name": "RB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42229-1", "protein_name": "Signal transducer and activator of transcription 5A", "gene_name": "STAT5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9UL18-1", "protein_name": "Protein argonaute-1", "gene_name": "AGO1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HCJ0-3", "protein_name": "Trinucleotide repeat-containing gene 6C protein", "gene_name": "TNRC6C", "tax_name": "Human" }, { "uniprot_canonical_ac": "P26358-1", "protein_name": "DNA (cytosine-5)-methyltransferase 1", "gene_name": "DNMT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P28482-1", "protein_name": "Mitogen-activated protein kinase 1", "gene_name": "MAPK1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P17275-1", "protein_name": "Transcription factor JunB", "gene_name": "JUNB", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13616-1", "protein_name": "Cullin-1", "gene_name": "CUL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13547-1", "protein_name": "Histone deacetylase 1", "gene_name": "HDAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13651-1", "protein_name": "Interleukin-10 receptor subunit alpha", "gene_name": "IL10RA", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"uniprot_canonical_ac": "Q9HCE1-1", "protein_name": "RNA helicase MOV-10", "gene_name": "MOV10", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92769-1", "protein_name": "Histone deacetylase 2", "gene_name": "HDAC2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15672-1", "protein_name": "Twist-related protein 1", "gene_name": "TWIST1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q15306-1", "protein_name": "Interferon regulatory factor 4", "gene_name": "IRF4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y6W8-1", "protein_name": "Inducible T-cell costimulator", "gene_name": "ICOS", "tax_name": "Human" }, { "uniprot_canonical_ac": "P62753-1", "protein_name": "Small ribosomal subunit protein eS6", "gene_name": "RPS6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14635-1", "protein_name": "G2/mitotic-specific cyclin-B1", "gene_name": "CCNB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P43403-1", "protein_name": "Tyrosine-protein kinase ZAP-70", "gene_name": "ZAP70", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27361-1", "protein_name": "Mitogen-activated protein kinase 3", "gene_name": "MAPK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P10144-1", "protein_name": "Granzyme B", "gene_name": "GZMB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P14222-1", "protein_name": "Perforin-1", "gene_name": "PRF1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q86WB0-1", "protein_name": "Zinc finger C3HC-type protein 1", "gene_name": "ZC3HC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63208-1", "protein_name": "S-phase kinase-associated protein 1", "gene_name": "SKP1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.21715655", "abstract": "", 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polymorphisms with susceptibility to non-small-cell lung cancer.", "journal": "Translational research : the journal of laboratory and clinical medicine", "date": "2012", "authors": "Kuo WH, Shih CM, Lin CW, Cheng WE, Chen SC, Chen W, Lee YL", "reference": { "type": "PubMed", "id": "22153809", "url": "https://pubmed.ncbi.nlm.nih.gov/22153809" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.22153809", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "In silico structural and functional characterization of the RSUME splice variants.", "journal": "PLoS ONE", "date": "2013", "authors": "Gerez J, Fuertes M, Tedesco L, Silberstein S, Sevlever G, Paez-Pereda M, Holsboer F, Turjanski AG, Arzt E", "reference": { "type": "PubMed", "id": "23469069", "url": "https://pubmed.ncbi.nlm.nih.gov/23469069" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P25963-1", "protein_name": "NF-kappa-B inhibitor alpha", "gene_name": "NFKBIA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y3V2-1", "protein_name": "RWD domain-containing protein 3", "gene_name": "RWDD3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P63279-1", "protein_name": "SUMO-conjugating enzyme UBC9", "gene_name": "UBE2I", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.23469069", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Lack of relevance of HIF-1alpha polymorphisms in breast cancer in a Portuguese population.", "journal": "Anticancer research", "date": "2013", "authors": "Ribeiro AL, Gaspar JF, Pereira T, Ribeiro V", "reference": { "type": "PubMed", "id": "23749907", "url": "https://pubmed.ncbi.nlm.nih.gov/23749907" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.23749907", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], 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"common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.23928995", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", 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"glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "PRDM1/BLIMP1 is commonly inactivated in anaplastic large T-cell lymphoma.", "journal": "Blood", "date": "2013", "authors": "Boi M, Rinaldi A, Kwee I, Bonetti P, Todaro M, Tabbo F, Piva R, Rancoita PM, Matolcsy A, Timar B, Tousseyn T, Rodriguez-Pinilla SM, Piris MA, Bea S, Campo E, Bhagat G, Swerdlow SH, Rosenwald A, Ponzoni M, Young KH, Piccaluga PP, Dummer R, Pileri S, Zucca E, Inghirami G, Bertoni F", "reference": { "type": "PubMed", "id": "24004669", "url": "https://pubmed.ncbi.nlm.nih.gov/24004669" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P26358-1", "protein_name": "DNA (cytosine-5)-methyltransferase 1", "gene_name": "DNMT1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13547-1", "protein_name": "Histone deacetylase 1", "gene_name": "HDAC1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P31785-1", "protein_name": "Cytokine receptor common subunit gamma", "gene_name": "IL2RG", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75626-1", "protein_name": "PR domain zinc finger protein 1", "gene_name": "PRDM1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NZQ7-1", "protein_name": "Programmed cell death 1 ligand 1", "gene_name": "CD274", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96ST3-1", "protein_name": "Paired amphipathic helix protein Sin3a", "gene_name": "SIN3A", "tax_name": "Human" }, { "uniprot_canonical_ac": "O15379-1", "protein_name": "Histone deacetylase 3", "gene_name": "HDAC3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" }, { "uniprot_canonical_ac": "P40763-1", "protein_name": "Signal transducer and activator of transcription 3", "gene_name": "STAT3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q92769-1", "protein_name": "Histone deacetylase 2", "gene_name": "HDAC2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.24004669", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 11 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 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"CDK1 stabilizes HIF-1alpha via direct phosphorylation of Ser668 to promote tumor growth.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2013", "authors": "Warfel NA, Dolloff NG, Dicker DT, Malysz J, El-Deiry WS", "reference": { "type": "PubMed", "id": "24189531", "url": "https://pubmed.ncbi.nlm.nih.gov/24189531" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q16665-1", "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q16665", "url": "https://www.uniprot.org/uniprotkb/Q16665" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "phosphorylation": [ { "start_pos": 668, "end_pos": 668, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "IEDB", "id": "Q16665", "url": 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