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Biol. Chem.", "date": "2005", "authors": "Lu Kan V, Jong Kimberly A, Kim Gloria Y, Singh Jatinder, Dia Ederlyn Q, Yoshimoto Koji, Wang Maria Y, Cloughesy Timothy F, Nelson Stanley F, Mischel Paul S", "reference": { "type": "PubMed", "id": "15908427", "url": "https://pubmed.ncbi.nlm.nih.gov/15908427" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UM73-1", "protein_name": "ALK tyrosine kinase receptor", "gene_name": "ALK", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9UM73", "url": "https://www.uniprot.org/uniprotkb/Q9UM73" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.15908427", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], 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TL, Li N, Li L, Xia G, Steensma R, Chopiuk G, Jiang J, Wan Y, Ding P, Liu Y, Sun F, Schultz PG, Gray NS, Warmuth M", "reference": { "type": "PubMed", "id": "17185414", "url": "https://pubmed.ncbi.nlm.nih.gov/17185414" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UM73-1", "protein_name": "ALK tyrosine kinase receptor", "gene_name": "ALK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UXT8-1", "protein_name": "ALK and LTK ligand 1", "gene_name": "ALKAL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75688-1", "protein_name": "Protein phosphatase 1B", "gene_name": "PPM1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UX46-1", "protein_name": "ALK and LTK ligand 2", "gene_name": "ALKAL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02751-15", "protein_name": "Fibronectin", "gene_name": "FN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04198-1", "protein_name": "N-myc proto-oncogene protein", "gene_name": "MYCN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42336-1", "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform", "gene_name": "PIK3CA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WU20-1", "protein_name": "Fibroblast growth factor receptor substrate 2", "gene_name": "FRS2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00291-1", "protein_name": "Huntingtin-interacting protein 1", "gene_name": "HIP1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P29350-1", "protein_name": "Tyrosine-protein phosphatase non-receptor type 6", "gene_name": "PTPN6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P52333-1", "protein_name": "Tyrosine-protein kinase JAK3", "gene_name": "JAK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q00610-1", "protein_name": "Clathrin heavy chain 1", "gene_name": "CLTC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P06748-1", "protein_name": "Nucleophosmin", "gene_name": "NPM1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O43815-1", "protein_name": "Striatin", "gene_name": "STRN", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00459-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit beta", "gene_name": "PIK3R2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P10644-1", "protein_name": "cAMP-dependent protein kinase type I-alpha regulatory subunit", "gene_name": "PRKAR1A", "tax_name": "Human" }, { "uniprot_canonical_ac": "P40763-1", "protein_name": "Signal transducer and activator of transcription 3", "gene_name": "STAT3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01106-2", "protein_name": "Myc proto-oncogene protein", "gene_name": "MYC", "tax_name": "Human" }, { "uniprot_canonical_ac": "P35568-1", "protein_name": "Insulin receptor substrate 1", "gene_name": "IRS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NR09-1", "protein_name": "Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6", "gene_name": "BIRC6", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NZJ5-1", "protein_name": "Eukaryotic translation initiation factor 2-alpha kinase 3", "gene_name": "EIF2AK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42338-1", "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform", "gene_name": "PIK3CB", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21246-1", "protein_name": "Pleiotrophin", "gene_name": "PTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H165-1", "protein_name": "BCL11 transcription factor A", "gene_name": "BCL11A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HC35-1", "protein_name": "Echinoderm microtubule-associated protein-like 4", "gene_name": "EML4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21741-1", "protein_name": "Midkine", "gene_name": "MDK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27986-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit alpha", 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receptor tyrosine kinase activation.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Perez-Pinera P, Zhang W, Chang Y, Vega JA, Deuel TF", "reference": { "type": "PubMed", "id": "17681947", "url": "https://pubmed.ncbi.nlm.nih.gov/17681947" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UM73-1", "protein_name": "ALK tyrosine kinase receptor", "gene_name": "ALK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UXT8-1", "protein_name": "ALK and LTK ligand 1", "gene_name": "ALKAL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UX46-1", "protein_name": "ALK and LTK ligand 2", "gene_name": "ALKAL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04198-1", "protein_name": "N-myc proto-oncogene protein", "gene_name": "MYCN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42336-1", "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform", "gene_name": "PIK3CA", 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Mitsudomi T, Tanio Y, Mano H", "reference": { "type": "PubMed", "id": "20979473", "url": "https://pubmed.ncbi.nlm.nih.gov/20979473" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UM73-1", "protein_name": "ALK tyrosine kinase receptor", "gene_name": "ALK", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9UM73", "url": "https://www.uniprot.org/uniprotkb/Q9UM73" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.20979473", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } 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"count": 0 } ], "sort_fields": [] } ] }, { "title": "Crizotinib, a small-molecule dual inhibitor of the c-Met and ALK receptor tyrosine kinases.", "journal": "Current opinion in investigational drugs (London, England : 2000)", "date": "2010", "authors": "Rodig SJ, Shapiro GI", "reference": { "type": "PubMed", "id": "21154129", "url": "https://pubmed.ncbi.nlm.nih.gov/21154129" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UM73-1", "protein_name": "ALK tyrosine kinase receptor", "gene_name": "ALK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UXT8-1", "protein_name": "ALK and LTK ligand 1", "gene_name": "ALKAL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UX46-1", "protein_name": "ALK and LTK ligand 2", "gene_name": "ALKAL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04198-1", "protein_name": "N-myc proto-oncogene protein", "gene_name": "MYCN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42336-1", "protein_name": 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"Sakamoto Hiroshi, Tsukaguchi Toshiyuki, Hiroshima Sayuri, Kodama Tatsushi, Kobayashi Takamitsu, Fukami Takaaki A, Oikawa Nobuhiro, Tsukuda Takuo, Ishii Nobuya, Aoki Yuko", "reference": { "type": "PubMed", "id": "21575866", "url": "https://pubmed.ncbi.nlm.nih.gov/21575866" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UM73-1", "protein_name": "ALK tyrosine kinase receptor", "gene_name": "ALK", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9UM73", "url": "https://www.uniprot.org/uniprotkb/Q9UM73" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.21575866", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ 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resistance to structurally diverse ALK inhibitors.", "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research", "date": "2011", "authors": "Heuckmann JM, Holzel M, Sos ML, Heynck S, Balke-Want H, Koker M, Peifer M, Weiss J, Lovly CM, Grutter C, Rauh D, Pao W, Thomas RK", "reference": { "type": "PubMed", "id": "21948233", "url": "https://pubmed.ncbi.nlm.nih.gov/21948233" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UM73-1", "protein_name": "ALK tyrosine kinase receptor", "gene_name": "ALK", "tax_name": "Human" }, { "uniprot_canonical_ac": "O75688-1", "protein_name": "Protein phosphatase 1B", "gene_name": "PPM1B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P02751-15", "protein_name": "Fibronectin", "gene_name": "FN1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00291-1", "protein_name": "Huntingtin-interacting protein 1", "gene_name": "HIP1", "tax_name": "Human" }, { 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Linderman DJ, Heasley LE, Franklin WA, Varella-Garcia M, Camidge DR", "reference": { "type": "PubMed", "id": "22235099", "url": "https://pubmed.ncbi.nlm.nih.gov/22235099" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UM73-1", "protein_name": "ALK tyrosine kinase receptor", "gene_name": "ALK", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9UM73", "url": "https://www.uniprot.org/uniprotkb/Q9UM73" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.22235099", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", 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"field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells.", "journal": "Oncogene", "date": "2012", "authors": "Schonherr C, Ruuth K, Kamaraj S, Wang CL, Yang HL, Combaret V, Djos A, Martinsson T, Christensen JG, Palmer RH, Hallberg B", "reference": { "type": "PubMed", "id": "22286764", "url": "https://pubmed.ncbi.nlm.nih.gov/22286764" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UM73-1", "protein_name": "ALK tyrosine kinase receptor", "gene_name": "ALK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UXT8-1", "protein_name": "ALK and LTK ligand 1", "gene_name": "ALKAL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UX46-1", "protein_name": "ALK and LTK ligand 2", "gene_name": "ALKAL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04198-1", "protein_name": "N-myc proto-oncogene protein", "gene_name": "MYCN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42336-1", "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform", "gene_name": "PIK3CA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WU20-1", "protein_name": "Fibroblast growth factor receptor substrate 2", "gene_name": "FRS2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P29350-1", "protein_name": "Tyrosine-protein phosphatase non-receptor type 6", "gene_name": "PTPN6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P52333-1", "protein_name": "Tyrosine-protein kinase JAK3", "gene_name": "JAK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00459-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit beta", "gene_name": "PIK3R2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P40763-1", "protein_name": "Signal transducer and activator of transcription 3", "gene_name": "STAT3", "tax_name": "Human" }, { 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"name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9UM73", "url": "https://www.uniprot.org/uniprotkb/Q9UM73" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.22286764", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 17 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": 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migration and invasion in neuroblastoma.", "journal": "Scientific reports", "date": "2013", "authors": "Hasan MK, Nafady A, Takatori A, Kishida S, Ohira M, Suenaga Y, Hossain S, Akter J, Ogura A, Nakamura Y, Kadomatsu K, Nakagawara A", "reference": { "type": "PubMed", "id": "24356251", "url": "https://pubmed.ncbi.nlm.nih.gov/24356251" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UM73-1", "protein_name": "ALK tyrosine kinase receptor", "gene_name": "ALK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UXT8-1", "protein_name": "ALK and LTK ligand 1", "gene_name": "ALKAL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UX46-1", "protein_name": "ALK and LTK ligand 2", "gene_name": "ALKAL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04198-1", "protein_name": "N-myc proto-oncogene protein", "gene_name": "MYCN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42336-1", "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Activating mutations in ALK kinase domain confer resistance to structurally unrelated ALK inhibitors in NPM-ALK-positive anaplastic large-cell lymphoma.", "journal": "Journal of cancer research and clinical oncology", "date": "2014", "authors": "Zdzalik D, Dymek B, Grygielewicz P, Gunerka P, Bujak A, Lamparska-Przybysz M, Wieczorek M, Dzwonek K", "reference": { "type": "PubMed", "id": "24509625", "url": "https://pubmed.ncbi.nlm.nih.gov/24509625" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UM73-1", "protein_name": "ALK tyrosine kinase receptor", "gene_name": "ALK", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9UM73", "url": "https://www.uniprot.org/uniprotkb/Q9UM73" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.24509625", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } 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"gene_name": "PTN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P21741-1", "protein_name": "Midkine", "gene_name": "MDK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27986-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit alpha", "gene_name": "PIK3R1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P19174-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1", "gene_name": "PLCG1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9UM73", "url": "https://www.uniprot.org/uniprotkb/Q9UM73" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.24670165", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 17 } ], 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patients who progressed on crizotinib.", "journal": "Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer", "date": "2014", "authors": "Ignatius Ou SH, Azada M, Hsiang DJ, Herman JM, Kain TS, Siwak-Tapp C, Casey C, He J, Ali SM, Klempner SJ, Miller VA", "reference": { "type": "PubMed", "id": "24736079", "url": "https://pubmed.ncbi.nlm.nih.gov/24736079" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UM73-1", "protein_name": "ALK tyrosine kinase receptor", "gene_name": "ALK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UXT8-1", "protein_name": "ALK and LTK ligand 1", "gene_name": "ALKAL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UX46-1", "protein_name": "ALK and LTK ligand 2", "gene_name": "ALKAL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04198-1", "protein_name": "N-myc proto-oncogene protein", "gene_name": "MYCN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42336-1", "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform", "gene_name": "PIK3CA", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8WU20-1", "protein_name": "Fibroblast growth factor receptor substrate 2", "gene_name": "FRS2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P29350-1", "protein_name": "Tyrosine-protein phosphatase non-receptor type 6", "gene_name": "PTPN6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P52333-1", "protein_name": "Tyrosine-protein kinase JAK3", "gene_name": "JAK3", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00459-1", "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit beta", "gene_name": "PIK3R2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P40763-1", "protein_name": "Signal transducer and activator of transcription 3", "gene_name": "STAT3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P01106-2", "protein_name": "Myc proto-oncogene 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lymphoma kinase (ALK) inhibitor for overcoming clinically-acquired resistance.", "journal": "Acta pharmaceutica Sinica. 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"Augmentor alpha and beta (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2015", "authors": "Reshetnyak AV, Murray PB, Shi X, Mo ES, Mohanty J, Tome F, Bai H, Gunel M, Lax I, Schlessinger J", "reference": { "type": "PubMed", "id": "26630010", "url": "https://pubmed.ncbi.nlm.nih.gov/26630010" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UM73-1", "protein_name": "ALK tyrosine kinase receptor", "gene_name": "ALK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UXT8-1", "protein_name": "ALK and LTK ligand 1", "gene_name": "ALKAL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UX46-1", "protein_name": "ALK and LTK ligand 2", "gene_name": "ALKAL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04198-1", "protein_name": "N-myc proto-oncogene protein", 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Oncology", "date": "2016", "authors": "Shaw AT, Gandhi L, Gadgeel S, Riely GJ, Cetnar J, West H, Camidge DR, Socinski MA, Chiappori A, Mekhail T, Chao BH, Borghaei H, Gold KA, Zeaiter A, Bordogna W, Balas B, Puig O, Henschel V, Ou SI", "reference": { "type": "PubMed", "id": "26708155", "url": "https://pubmed.ncbi.nlm.nih.gov/26708155" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UM73-1", "protein_name": "ALK tyrosine kinase receptor", "gene_name": "ALK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UXT8-1", "protein_name": "ALK and LTK ligand 1", "gene_name": "ALKAL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UX46-1", "protein_name": "ALK and LTK ligand 2", "gene_name": "ALKAL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04198-1", "protein_name": "N-myc proto-oncogene protein", "gene_name": "MYCN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42336-1", "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase 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cancer (Amsterdam, Netherlands)", "date": "2016", "authors": "Kodityal S, Elvin JA, Squillace R, Agarwal N, Miller VA, Ali SM, Klempner SJ, Ou SH", "reference": { "type": "PubMed", "id": "26775591", "url": "https://pubmed.ncbi.nlm.nih.gov/26775591" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UM73-1", "protein_name": "ALK tyrosine kinase receptor", "gene_name": "ALK", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9UM73", "url": "https://www.uniprot.org/uniprotkb/Q9UM73" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.26775591", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", 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G, Dias-Santagata D, Heist RS, Lennerz J, Sequist LV, Benes CH, Iafrate AJ, Mino-Kenudson M, Engelman JA, Shaw AT", "reference": { "type": "PubMed", "id": "27432227", "url": "https://pubmed.ncbi.nlm.nih.gov/27432227" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UM73-1", "protein_name": "ALK tyrosine kinase receptor", "gene_name": "ALK", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9UM73", "url": "https://www.uniprot.org/uniprotkb/Q9UM73" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.27432227", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { 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"glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION.", "journal": "The Journal of biological chemistry", "date": "2016", "authors": "Kuboyama K, Fujikawa A, Suzuki R, Tanga N, Noda M", "reference": { "type": "PubMed", "id": "27445335", "url": "https://pubmed.ncbi.nlm.nih.gov/27445335" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UM73-1", "protein_name": 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", 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"Reshetnyak AV, Mohanty J, Tome F, Puleo DE, Plotnikov AN, Ahmed M, Kaur N, Poliakov A, Cinnaiyan AM, Lax I, Schlessinger J", "reference": { "type": "PubMed", "id": "30061385", "url": "https://pubmed.ncbi.nlm.nih.gov/30061385" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9UM73-1", "protein_name": "ALK tyrosine kinase receptor", "gene_name": "ALK", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UXT8-1", "protein_name": "ALK and LTK ligand 1", "gene_name": "ALKAL1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q6UX46-1", "protein_name": "ALK and LTK ligand 2", "gene_name": "ALKAL2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P04198-1", "protein_name": "N-myc proto-oncogene protein", "gene_name": "MYCN", "tax_name": "Human" }, { "uniprot_canonical_ac": "P42336-1", "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform", "gene_name": "PIK3CA", "tax_name": "Human" }, { "uniprot_canonical_ac": 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