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        "title": "Identification of beta-carotene 15,15'-monooxygenase as a peroxisome proliferator-activated receptor target gene.",
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        "title": "Key role of conserved histidines in recombinant mouse beta-carotene 15,15'-monooxygenase-1 activity.",
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                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9JJS6",
                        "url": "https://www.uniprot.org/uniprotkb/Q9JJS6"
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                        "database": "PubMed",
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            {
                "start_pos": 309,
                "end_pos": 309,
                "sequence_org": "H",
                "sequence_mut": "A",
                "comment": "No significant effect on beta-carotene 15,15'-monooxygenase activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9JJS6",
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                    {
                        "database": "PubMed",
                        "id": "15951442",
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                ],
                "uniprot_canonical_ac": "Q9JJS6-1"
            },
            {
                "start_pos": 314,
                "end_pos": 314,
                "sequence_org": "E",
                "sequence_mut": "A",
                "comment": "No significant effect on beta-carotene 15,15'-monooxygenase activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9JJS6",
                        "url": "https://www.uniprot.org/uniprotkb/Q9JJS6"
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                    {
                        "database": "PubMed",
                        "id": "15951442",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/15951442"
                    }
                ],
                "uniprot_canonical_ac": "Q9JJS6-1"
            },
            {
                "start_pos": 405,
                "end_pos": 405,
                "sequence_org": "E",
                "sequence_mut": "A",
                "comment": "Loss of beta-carotene 15,15'-monooxygenase activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9JJS6",
                        "url": "https://www.uniprot.org/uniprotkb/Q9JJS6"
                    },
                    {
                        "database": "PubMed",
                        "id": "15951442",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/15951442"
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                ],
                "uniprot_canonical_ac": "Q9JJS6-1"
            },
            {
                "start_pos": 450,
                "end_pos": 450,
                "sequence_org": "E",
                "sequence_mut": "A",
                "comment": "No significant effect on beta-carotene 15,15'-monooxygenase activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9JJS6",
                        "url": "https://www.uniprot.org/uniprotkb/Q9JJS6"
                    },
                    {
                        "database": "PubMed",
                        "id": "15951442",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/15951442"
                    }
                ],
                "uniprot_canonical_ac": "Q9JJS6-1"
            },
            {
                "start_pos": 457,
                "end_pos": 457,
                "sequence_org": "E",
                "sequence_mut": "A",
                "comment": "Decreased beta-carotene 15,15'-monooxygenase activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9JJS6",
                        "url": "https://www.uniprot.org/uniprotkb/Q9JJS6"
                    },
                    {
                        "database": "PubMed",
                        "id": "15951442",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/15951442"
                    }
                ],
                "uniprot_canonical_ac": "Q9JJS6-1"
            },
            {
                "start_pos": 469,
                "end_pos": 469,
                "sequence_org": "E",
                "sequence_mut": "A",
                "comment": "Decreased beta-carotene 15,15'-monooxygenase activity.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "Q9JJS6",
                        "url": "https://www.uniprot.org/uniprotkb/Q9JJS6"
                    },
                    {
                        "database": "PubMed",
                        "id": "15951442",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/15951442"
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                ],
                "uniprot_canonical_ac": "Q9JJS6-1"
            },
            {
                "start_pos": 49,
                "end_pos": 49,
                "sequence_org": "H",
                "sequence_mut": "A",
                "comment": "No significant effect on beta-carotene 15,15'-monooxygenase activity. Decreased stability.",
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                    {
                        "database": "UniProtKB",
                        "id": "Q9JJS6",
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                    {
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                        "url": "https://pubmed.ncbi.nlm.nih.gov/15951442"
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            {
                "start_pos": 514,
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                "sequence_org": "H",
                "sequence_mut": "A",
                "comment": "No effect on protein abundance. Loss of beta-carotene 15,15'-monooxygenase activity. Loss of iron binding.",
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                    {
                        "database": "UniProtKB",
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                ],
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            {
                "start_pos": 52,
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                "sequence_org": "D",
                "sequence_mut": "A",
                "comment": "Decreased beta-carotene 15,15'-monooxygenase activity. Decreased catalytic efficiency. Loss of beta-carotene 15,15'-monooxygenase activity; when associated with A-140.",
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                    {
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                        "id": "Q9JJS6",
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                ],
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            {
                "start_pos": 58,
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                "sequence_mut": "A",
                "comment": "No significant effect on beta-carotene 15,15'-monooxygenase activity. Decreased catalytic efficiency.",
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    {
        "title": "Genetic tuning of \u03b2-carotene oxygenase-1 activity rescues cone photoreceptor function in STRA6-deficient mice.",
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    {
        "title": "c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation.",
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                "sort_fields": []
            }
        ]
    }
]
