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"uniprot_canonical_ac": "P78527-1", "protein_name": "DNA-dependent protein kinase catalytic subunit", "gene_name": "PRKDC", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q924T3-1", "protein_name": "DNA repair protein XRCC4", "gene_name": "Xrcc4", "tax_name": "Mouse" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 260, "end_pos": 260, "sequence_org": "S", "sequence_mut": "A", "comment": "Reduced phosphorylation by PRKDC. In XRCC4-Ala mutant; abolished phosphorylation by PRKDC; does not affect ability to bridge DNA when associated with NHEJ1/XLF phosphorylation-defective mutant; when associated with A-193, A-304, A-315, A-320, A-323, A-327 and A-328.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "30247612", "url": "https://pubmed.ncbi.nlm.nih.gov/30247612" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" }, { "database": "PubMed", "id": "14599745", "url": "https://pubmed.ncbi.nlm.nih.gov/14599745" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 320, "end_pos": 320, "sequence_org": "S", "sequence_mut": "A", "comment": "Slightly reduced phosphorylation by PRKDC. In XRCC4-Ala mutant; abolished phosphorylation by PRKDC; does not affect ability to bridge DNA when associated with NHEJ1/XLF phosphorylation-defective mutant; when associated with A-193, A-260, A-304, A-315, A-323, A-327 and A-328.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" }, { "database": "PubMed", "id": "14599745", "url": "https://pubmed.ncbi.nlm.nih.gov/14599745" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 193, "end_pos": 193, "sequence_org": "S", "sequence_mut": "A", "comment": "In 9A mutant; abolished phosphorylation by PRKDC; does not affect ability to repair double-strand breaks (DSBs), possibly because of redundancy with NHEJ1/XLF phosphorylation sites; when associated with A-53, A-254, A-295, A-307, A-312, A-315, A-319 and A-320.", "evidence": [ { "database": "UniProtKB", "id": "Q924T3", "url": "https://www.uniprot.org/uniprotkb/Q924T3" }, { "database": "PubMed", "id": "14599745", "url": "https://pubmed.ncbi.nlm.nih.gov/14599745" } ], "uniprot_canonical_ac": "Q924T3-1" }, { "start_pos": 254, "end_pos": 254, "sequence_org": "S", "sequence_mut": "A", "comment": "In 9A mutant; 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abolished phosphorylation by PRKDC; does not affect ability to repair double-strand breaks (DSBs), possibly because of redundancy with NHEJ1/XLF phosphorylation sites; when associated with A-53, A-193, A-254, A-295, A-312, A-315, A-319 and A-320.", "evidence": [ { "database": "UniProtKB", "id": "Q924T3", "url": "https://www.uniprot.org/uniprotkb/Q924T3" }, { "database": "PubMed", "id": "14599745", "url": "https://pubmed.ncbi.nlm.nih.gov/14599745" } ], "uniprot_canonical_ac": "Q924T3-1" }, { "start_pos": 312, "end_pos": 312, "sequence_org": "S", "sequence_mut": "A", "comment": "In 9A mutant; abolished phosphorylation by PRKDC; does not affect ability to repair double-strand breaks (DSBs), possibly because of redundancy with NHEJ1/XLF phosphorylation sites; when associated with A-53, A-193, A-254, A-295, A-307, A-315, A-319 and A-320.", "evidence": [ { "database": "UniProtKB", "id": "Q924T3", "url": "https://www.uniprot.org/uniprotkb/Q924T3" }, { "database": "PubMed", "id": "14599745", "url": "https://pubmed.ncbi.nlm.nih.gov/14599745" } ], "uniprot_canonical_ac": "Q924T3-1" }, { "start_pos": 315, "end_pos": 315, "sequence_org": "T", "sequence_mut": "A", "comment": "In 9A mutant; abolished phosphorylation by PRKDC; does not affect ability to repair double-strand breaks (DSBs), possibly because of redundancy with NHEJ1/XLF phosphorylation sites; when associated with A-53, A-193, A-254, A-295, A-307, A-312, A-319 and A-320.", "evidence": [ { "database": "UniProtKB", "id": "Q924T3", "url": "https://www.uniprot.org/uniprotkb/Q924T3" }, { "database": "PubMed", "id": "14599745", "url": "https://pubmed.ncbi.nlm.nih.gov/14599745" } ], "uniprot_canonical_ac": "Q924T3-1" }, { "start_pos": 319, "end_pos": 319, "sequence_org": "S", "sequence_mut": "A", "comment": "In 9A mutant; abolished phosphorylation by PRKDC; does not affect ability to repair double-strand breaks (DSBs), possibly because of redundancy with NHEJ1/XLF phosphorylation sites; when associated with A-53, A-193, A-254, A-295, A-307, A-312, A-315 and A-320.", "evidence": [ { "database": "UniProtKB", "id": "Q924T3", "url": "https://www.uniprot.org/uniprotkb/Q924T3" }, { "database": "PubMed", "id": "14599745", "url": "https://pubmed.ncbi.nlm.nih.gov/14599745" } ], "uniprot_canonical_ac": "Q924T3-1" }, { "start_pos": 320, "end_pos": 320, "sequence_org": "S", "sequence_mut": "A", "comment": "In 9A mutant; abolished phosphorylation by PRKDC; does not affect ability to repair double-strand breaks (DSBs), possibly because of redundancy with NHEJ1/XLF phosphorylation sites; when associated with A-53, A-193, A-254, A-295, A-307, A-312, A-315 and A-319.", "evidence": [ { "database": "UniProtKB", "id": "Q924T3", "url": "https://www.uniprot.org/uniprotkb/Q924T3" }, { "database": "PubMed", "id": "14599745", "url": "https://pubmed.ncbi.nlm.nih.gov/14599745" } ], "uniprot_canonical_ac": "Q924T3-1" }, { "start_pos": 53, "end_pos": 53, "sequence_org": "S", "sequence_mut": "A", "comment": "In 9A mutant; abolished phosphorylation by PRKDC; does not affect ability to repair double-strand breaks (DSBs), possibly because of redundancy with NHEJ1/XLF phosphorylation sites; when associated with A-193, A-254, A-295, A-307, A-312, A-315, A-319 and A-320.", "evidence": [ { "database": "UniProtKB", "id": "Q924T3", "url": "https://www.uniprot.org/uniprotkb/Q924T3" }, { "database": "PubMed", "id": "14599745", "url": "https://pubmed.ncbi.nlm.nih.gov/14599745" } ], "uniprot_canonical_ac": "Q924T3-1" } ], "phosphorylation": [ { "start_pos": 193, "end_pos": 193, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; 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"total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation.", "journal": "DNA Repair", "date": "2008", "authors": "Macrae CJ, McCulloch RD, Ylanko J, Durocher D, Koch CA", "reference": { "type": "PubMed", "id": "18077224", "url": "https://pubmed.ncbi.nlm.nih.gov/18077224" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q13426-1", "protein_name": "DNA repair protein XRCC4", "gene_name": "XRCC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8IW19-1", "protein_name": "Aprataxin and PNK-like factor", "gene_name": "APLF", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.18077224", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Crystal structure of human XLF: a twist in nonhomologous DNA end-joining.", "journal": "Molecular cell", "date": "2007", "authors": "Andres SN, Modesti M, Tsai CJ, Chu G, Junop MS", "reference": { "type": "PubMed", "id": "18158905", "url": "https://pubmed.ncbi.nlm.nih.gov/18158905" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q13426-1", "protein_name": "DNA repair protein XRCC4", "gene_name": "XRCC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H9Q4-1", "protein_name": "Non-homologous end-joining factor 1", "gene_name": "NHEJ1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 102, "end_pos": 102, "sequence_org": "K", "sequence_mut": "E", "comment": "Abolished interaction with NHEJ1/XLF; when associated with E-65.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "18158905", "url": "https://pubmed.ncbi.nlm.nih.gov/18158905" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 26, "end_pos": 26, "sequence_org": "K", "sequence_mut": "E", "comment": "Abolished interaction with NHEJ1/XLF; when associated with E-99.", "evidence": [ { 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Abolished interaction with NHEJ1/XLF; when associated with E-99. Abolished ability to bridge DNA; when associated with E-99. Abolished interaction with NHEJ1/XLF; when associated with E-102.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "18158905", "url": "https://pubmed.ncbi.nlm.nih.gov/18158905" }, { "database": "PubMed", "id": "22287571", "url": "https://pubmed.ncbi.nlm.nih.gov/22287571" }, { "database": "PubMed", "id": "21768349", "url": "https://pubmed.ncbi.nlm.nih.gov/21768349" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 71, "end_pos": 71, "sequence_org": "R", "sequence_mut": "E", "comment": "Abolished interaction with NHEJ1/XLF; when associated with E-99.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "18158905", "url": "https://pubmed.ncbi.nlm.nih.gov/18158905" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 72, "end_pos": 72, "sequence_org": "K", "sequence_mut": "E", "comment": "Abolished interaction with NHEJ1/XLF; when associated with E-99. 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Abolished ability to bridge DNA; when associated with E-72 and E-90.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "18158905", "url": "https://pubmed.ncbi.nlm.nih.gov/18158905" }, { "database": "PubMed", "id": "22287571", "url": "https://pubmed.ncbi.nlm.nih.gov/22287571" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 105, "end_pos": 105, "sequence_org": "I", "sequence_mut": "S", "comment": "Does not affect ability to repair double-strand breaks (DSBs). 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Some studies show lack of interaction with XRCC4 while another shows that this mutant retains the ability to interact with XRCC4.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "30177755", "url": "https://pubmed.ncbi.nlm.nih.gov/30177755" }, { "database": "PubMed", "id": "18158905", "url": "https://pubmed.ncbi.nlm.nih.gov/18158905" }, { "database": "PubMed", "id": "22287571", "url": "https://pubmed.ncbi.nlm.nih.gov/22287571" }, { "database": "PubMed", "id": "26100018", "url": "https://pubmed.ncbi.nlm.nih.gov/26100018" }, { "database": "PubMed", "id": "21775435", "url": "https://pubmed.ncbi.nlm.nih.gov/21775435" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 115, "end_pos": 115, "sequence_org": "L", "sequence_mut": "D", "comment": "Impaired ability to repair double-strand breaks (DSBs). Abolished ability to bridge DNA. Abolished ability to participate in V(D)J recombination. Abolished interaction with XRCC4.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "18158905", "url": "https://pubmed.ncbi.nlm.nih.gov/18158905" }, { "database": "PubMed", "id": "22287571", "url": "https://pubmed.ncbi.nlm.nih.gov/22287571" }, { "database": "PubMed", "id": "26100018", "url": "https://pubmed.ncbi.nlm.nih.gov/26100018" }, { "database": "PubMed", "id": "20558749", "url": "https://pubmed.ncbi.nlm.nih.gov/20558749" }, { "database": "PubMed", "id": "21775435", "url": "https://pubmed.ncbi.nlm.nih.gov/21775435" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 169, "end_pos": 169, "sequence_org": "E", "sequence_mut": "A", "comment": "Does not affect ability to repair double-strand breaks (DSBs). Does not affect interaction with XRCC4.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "18158905", "url": "https://pubmed.ncbi.nlm.nih.gov/18158905" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 174, "end_pos": 174, "sequence_org": "L", "sequence_mut": "A", "comment": "Impaired ability to repair double-strand breaks (DSBs). Does not affect interaction with XRCC4.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "18158905", "url": "https://pubmed.ncbi.nlm.nih.gov/18158905" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 178, "end_pos": 178, "sequence_org": "R", "sequence_mut": "A", "comment": "Impaired ability to repair double-strand breaks (DSBs). Does not affect interaction with XRCC4. Does not affect ability to participate in V(D)J recombination.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "18158905", "url": "https://pubmed.ncbi.nlm.nih.gov/18158905" }, { "database": "PubMed", "id": "20558749", "url": "https://pubmed.ncbi.nlm.nih.gov/20558749" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 179, "end_pos": 179, "sequence_org": "L", "sequence_mut": "A", "comment": "Impaired ability to repair double-strand breaks (DSBs). Does not affect interaction with XRCC4.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "18158905", "url": "https://pubmed.ncbi.nlm.nih.gov/18158905" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 185, "end_pos": 185, "sequence_org": "E", "sequence_mut": "A", "comment": "Does not affect ability to repair double-strand breaks (DSBs). Does not affect interaction with XRCC4.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "18158905", "url": "https://pubmed.ncbi.nlm.nih.gov/18158905" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 195, "end_pos": 195, "sequence_org": "I", "sequence_mut": "A", "comment": "Does not affect ability to repair double-strand breaks (DSBs). Does not affect interaction with XRCC4.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "18158905", "url": "https://pubmed.ncbi.nlm.nih.gov/18158905" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 278, "end_pos": 278, "sequence_org": "S", "sequence_mut": "A", "comment": "Does not affect ability to repair double-strand breaks (DSBs). Does not affect interaction with XRCC4.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "18158905", "url": "https://pubmed.ncbi.nlm.nih.gov/18158905" } ], "uniprot_canonical_ac": "Q9H9Q4-1" } ], "record_id": "pubmed.18158905", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4.", "journal": "Mol. Cell. Biol.", "date": "2009", "authors": "Wu Pe\u00ef-Yu, Frit Philippe, Meesala SriLakshmi, Dauvillier St\u00e9phanie, Modesti Mauro, Andres Sara N, Huang Ying, Sekiguchi JoAnn, Calsou Patrick, Salles Bernard, Junop Murray S", "reference": { "type": "PubMed", "id": "19332554", "url": "https://pubmed.ncbi.nlm.nih.gov/19332554" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q13426-1", "protein_name": "DNA repair protein XRCC4", "gene_name": "XRCC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49917-1", "protein_name": "DNA ligase 4", "gene_name": "LIG4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.19332554", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": 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"glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Delineation of the Xrcc4-interacting region in the globular head domain of cernunnos/XLF.", "journal": "J. Biol. Chem.", "date": "2010", "authors": "Malivert L, Ropars V, Nunez M, Drevet P, Miron S, Faure G, Guerois R, Mornon JP, Revy P, Charbonnier JB, Callebaut I, de Villartay JP", "reference": { "type": "PubMed", "id": "20558749", "url": "https://pubmed.ncbi.nlm.nih.gov/20558749" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q13426-1", "protein_name": "DNA repair protein XRCC4", "gene_name": "XRCC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H9Q4-1", "protein_name": "Non-homologous end-joining factor 1", "gene_name": "NHEJ1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 115, "end_pos": 115, "sequence_org": "L", "sequence_mut": "D", "comment": "Impaired ability to repair double-strand breaks (DSBs). Abolished ability to bridge DNA. Abolished ability to participate in V(D)J recombination. 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Does not affect interaction with XRCC4. Does not affect ability to participate in V(D)J recombination.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "18158905", "url": "https://pubmed.ncbi.nlm.nih.gov/18158905" }, { "database": "PubMed", "id": "20558749", "url": "https://pubmed.ncbi.nlm.nih.gov/20558749" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 182, "end_pos": 182, "sequence_org": "E", "sequence_mut": "A", "comment": "Does not affect ability to participate in V(D)J recombination.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "20558749", "url": "https://pubmed.ncbi.nlm.nih.gov/20558749" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 189, "end_pos": 190, "sequence_org": "FL", "sequence_mut": "DD", "comment": "Does not affect ability to participate in V(D)J recombination.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "20558749", "url": "https://pubmed.ncbi.nlm.nih.gov/20558749" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 24, "end_pos": 24, "sequence_org": "L", "sequence_mut": "A", "comment": "Does not affect ability to participate in V(D)J recombination.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "20558749", "url": "https://pubmed.ncbi.nlm.nih.gov/20558749" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 26, "end_pos": 26, "sequence_org": "K", "sequence_mut": "A", "comment": "Abolished ability to participate in V(D)J recombination.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "20558749", "url": "https://pubmed.ncbi.nlm.nih.gov/20558749" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 37, "end_pos": 37, "sequence_org": "L", "sequence_mut": "A", "comment": "Does not affect ability to participate in V(D)J recombination.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "20558749", "url": "https://pubmed.ncbi.nlm.nih.gov/20558749" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 40, "end_pos": 40, "sequence_org": "D", "sequence_mut": "A", "comment": "Does not affect ability to participate in V(D)J recombination.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "20558749", "url": "https://pubmed.ncbi.nlm.nih.gov/20558749" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 40, "end_pos": 40, "sequence_org": "D", "sequence_mut": "P", "comment": "Does not affect ability to participate in V(D)J recombination.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "20558749", "url": "https://pubmed.ncbi.nlm.nih.gov/20558749" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 41, "end_pos": 41, "sequence_org": "L", "sequence_mut": "A", "comment": "Does not affect ability to participate in V(D)J recombination.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "20558749", "url": "https://pubmed.ncbi.nlm.nih.gov/20558749" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 43, "end_pos": 43, "sequence_org": "Q", "sequence_mut": "A", "comment": "Does not affect ability to participate in V(D)J recombination.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "20558749", "url": "https://pubmed.ncbi.nlm.nih.gov/20558749" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 61, "end_pos": 61, "sequence_org": "L", "sequence_mut": "E", "comment": "Does not affect ability to participate in V(D)J recombination.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "20558749", "url": "https://pubmed.ncbi.nlm.nih.gov/20558749" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 64, "end_pos": 64, "sequence_org": "R", "sequence_mut": "E", "comment": "Abolished ability to repair double-strand breaks (DSBs). 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abolished phosphorylation; does not affect ability to repair double-strand breaks (DSBs), possibly because of redundancy with XRCC4 phosphorylation sites; when associated with A-132, A-245, A-251, A-263 and A-266. 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In XLF-Ala mutant; abolished phosphorylation by PRKDC; does not affect ability to bridge DNA when associated with XRCC4 phosphorylation-defective mutant; when associated with A-132, A-203 and A-251.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "22228831", "url": "https://pubmed.ncbi.nlm.nih.gov/22228831" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" }, { "database": "PubMed", "id": "18644470", "url": "https://pubmed.ncbi.nlm.nih.gov/18644470" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 251, "end_pos": 251, "sequence_org": "S", "sequence_mut": "A", "comment": "In 6A mutant; abolished phosphorylation; does not affect ability to repair double-strand breaks (DSBs), possibly because of redundancy with XRCC4 phosphorylation sites; when associated with A-132, A-203, A-245, A-263 and A-266. 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"abstract": "", "glycosylation": [], "snv": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 14 }, { "field": "total_sites", "count": 14 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl", "uniprot_canonical_ac" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "A human XRCC4-XLF complex bridges DNA.", "journal": "Nucleic acids research", "date": "2012", "authors": "Andres SN, Vergnes A, Ristic D, Wyman C, Modesti M, Junop M", "reference": { "type": "PubMed", "id": "22287571", "url": "https://pubmed.ncbi.nlm.nih.gov/22287571" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q13426-1", "protein_name": "DNA repair protein XRCC4", "gene_name": "XRCC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H9Q4-1", "protein_name": "Non-homologous end-joining factor 1", "gene_name": "NHEJ1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 170, "end_pos": 170, "sequence_org": "E", "sequence_mut": "A", "comment": "Abolished DNA-binding.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "22287571", "url": "https://pubmed.ncbi.nlm.nih.gov/22287571" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 192, "end_pos": 192, "sequence_org": "R", "sequence_mut": "A", "comment": "Abolished DNA-binding.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "22287571", "url": "https://pubmed.ncbi.nlm.nih.gov/22287571" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 65, "end_pos": 65, "sequence_org": "K", "sequence_mut": "E", "comment": "Strongly decreased interaction with NHEJ1/XLF. Abolished interaction with NHEJ1/XLF; when associated with E-99. Abolished ability to bridge DNA; when associated with E-99. Abolished interaction with NHEJ1/XLF; when associated with E-102.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "18158905", "url": "https://pubmed.ncbi.nlm.nih.gov/18158905" }, { "database": "PubMed", "id": "22287571", "url": "https://pubmed.ncbi.nlm.nih.gov/22287571" }, { "database": "PubMed", "id": "21768349", "url": "https://pubmed.ncbi.nlm.nih.gov/21768349" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 72, "end_pos": 72, "sequence_org": "K", "sequence_mut": "E", "comment": "Abolished interaction with NHEJ1/XLF; when associated with E-99. Abolished ability to bridge DNA; when associated with E-90 and E-99.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "18158905", "url": "https://pubmed.ncbi.nlm.nih.gov/18158905" }, { "database": "PubMed", "id": "22287571", "url": "https://pubmed.ncbi.nlm.nih.gov/22287571" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 90, "end_pos": 90, "sequence_org": "K", "sequence_mut": "E", "comment": "Abolished ability to bridge DNA; when associated with E-72 and E-99.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "22287571", "url": "https://pubmed.ncbi.nlm.nih.gov/22287571" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 99, "end_pos": 99, "sequence_org": "K", "sequence_mut": "E", "comment": "Abolished interaction with NHEJ1/XLF; when associated with E-4 or E-26 or E-65 or E-71 or E-72. 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"table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining.", "journal": "eLife", "date": "2017", "authors": "Normanno D, Negrel A, de Melo AJ, Betzi S, Meek K, Modesti M", "reference": { "type": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q13426-1", "protein_name": "DNA repair protein XRCC4", "gene_name": "XRCC4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9H9Q4-1", "protein_name": "Non-homologous end-joining factor 1", "gene_name": "NHEJ1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 193, "end_pos": 193, "sequence_org": "S", "sequence_mut": "A", "comment": "In XRCC4-Ala mutant; abolished phosphorylation by PRKDC; does not affect ability to bridge DNA when associated with NHEJ1/XLF phosphorylation-defective mutant; when associated with A-260, A-304, A-315, A-320, A-323, A-327 and A-328.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 193, "end_pos": 193, "sequence_org": "S", "sequence_mut": "D", "comment": "In XRCC4-Asp mutant; phospho-mimetic mutant; abolished ability to bridge DNA when associated with NHEJ1/XLF phospho-mimetic mutant; when associated with D-260, D-304, D-315, D-320, D-323, D-327 and D-328.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 260, "end_pos": 260, "sequence_org": "S", "sequence_mut": "A", "comment": "Reduced phosphorylation by PRKDC. In XRCC4-Ala mutant; abolished phosphorylation by PRKDC; does not affect ability to bridge DNA when associated with NHEJ1/XLF phosphorylation-defective mutant; when associated with A-193, A-304, A-315, A-320, A-323, A-327 and A-328.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "30247612", "url": "https://pubmed.ncbi.nlm.nih.gov/30247612" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" }, { "database": "PubMed", "id": "14599745", "url": "https://pubmed.ncbi.nlm.nih.gov/14599745" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 260, "end_pos": 260, "sequence_org": "S", "sequence_mut": "D", "comment": "In XRCC4-Asp mutant; phospho-mimetic mutant; abolished ability to bridge DNA when associated with NHEJ1/XLF phospho-mimetic mutant; when associated with D-193, D-304, D-315, D-320, D-323, D-327 and D-328.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 304, "end_pos": 304, "sequence_org": "S", "sequence_mut": "A", "comment": "In XRCC4-Ala mutant; abolished phosphorylation by PRKDC; does not affect ability to bridge DNA when associated with NHEJ1/XLF phosphorylation-defective mutant; when associated with A-193, A-260, A-315, A-320, A-323, A-327 and A-328.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 304, "end_pos": 304, "sequence_org": "S", "sequence_mut": "D", "comment": "In XRCC4-Asp mutant; phospho-mimetic mutant; abolished ability to bridge DNA when associated with NHEJ1/XLF phospho-mimetic mutant; when associated with D-193, D-260, D-315, D-320, D-323, D-327 and D-328.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 315, "end_pos": 315, "sequence_org": "S", "sequence_mut": "A", "comment": "In XRCC4-Ala mutant; abolished phosphorylation by PRKDC; does not affect ability to bridge DNA when associated with NHEJ1/XLF phosphorylation-defective mutant; when associated with A-193, A-260, A-304, A-320, A-323, A-327 and A-328.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 315, "end_pos": 315, "sequence_org": "S", "sequence_mut": "D", "comment": "In XRCC4-Asp mutant; phospho-mimetic mutant; abolished ability to bridge DNA when associated with NHEJ1/XLF phospho-mimetic mutant; when associated with D-193, D-260, D-304, D-320, D-323, D-327 and D-328.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 320, "end_pos": 320, "sequence_org": "S", "sequence_mut": "A", "comment": "Slightly reduced phosphorylation by PRKDC. In XRCC4-Ala mutant; abolished phosphorylation by PRKDC; does not affect ability to bridge DNA when associated with NHEJ1/XLF phosphorylation-defective mutant; when associated with A-193, A-260, A-304, A-315, A-323, A-327 and A-328.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" }, { "database": "PubMed", "id": "14599745", "url": "https://pubmed.ncbi.nlm.nih.gov/14599745" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 320, "end_pos": 320, "sequence_org": "S", "sequence_mut": "D", "comment": "In XRCC4-Asp mutant; phospho-mimetic mutant; abolished ability to bridge DNA when associated with NHEJ1/XLF phospho-mimetic mutant; when associated with D-193, D-260, D-304, D-315, D-323, D-327 and D-328.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 323, "end_pos": 323, "sequence_org": "T", "sequence_mut": "A", "comment": "In XRCC4-Ala mutant; abolished phosphorylation by PRKDC; does not affect ability to bridge DNA when associated with NHEJ1/XLF phosphorylation-defective mutant; when associated with A-193, A-260, A-304, A-315, A-320, A-327 and A-328. Does not affect phosphorylation by CK2.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "15385968", "url": "https://pubmed.ncbi.nlm.nih.gov/15385968" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 323, "end_pos": 323, "sequence_org": "T", "sequence_mut": "D", "comment": "Does not affect ability mediate double-strand break repair. In XRCC4-Asp mutant; phospho-mimetic mutant; abolished ability to bridge DNA when associated with NHEJ1/XLF phospho-mimetic mutant; when associated with D-193, D-260, D-304, D-315, D-320, D-327 and D-328.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "25597996", "url": "https://pubmed.ncbi.nlm.nih.gov/25597996" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 327, "end_pos": 327, "sequence_org": "S", "sequence_mut": "A", "comment": "In XRCC4-Ala mutant; abolished phosphorylation by PRKDC; does not affect ability to bridge DNA when associated with NHEJ1/XLF phosphorylation-defective mutant; when associated with A-193, A-260, A-304, A-315, A-320, A-323 and A-328.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 327, "end_pos": 327, "sequence_org": "S", "sequence_mut": "D", "comment": "Does not affect ability mediate double-strand break repair. In XRCC4-Asp mutant; phospho-mimetic mutant; abolished ability to bridge DNA when associated with NHEJ1/XLF phospho-mimetic mutant; when associated with D-193, D-260, D-304, D-315, D-320, D-323 and D-328.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "25597996", "url": "https://pubmed.ncbi.nlm.nih.gov/25597996" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 328, "end_pos": 328, "sequence_org": "S", "sequence_mut": "A", "comment": "In XRCC4-Ala mutant; abolished phosphorylation by PRKDC; does not affect ability to bridge DNA when associated with NHEJ1/XLF phosphorylation-defective mutant; when associated with A-193, A-260, A-304, A-315, A-320, A-323 and A-327.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 328, "end_pos": 328, "sequence_org": "S", "sequence_mut": "D", "comment": "Does not affect ability mediate double-strand break repair. In XRCC4-Asp mutant; phospho-mimetic mutant; abolished ability to bridge DNA when associated with NHEJ1/XLF phospho-mimetic mutant; when associated with D-193, D-260, D-304, D-315, D-320, D-323 and D-327.", "evidence": [ { "database": "UniProtKB", "id": "Q13426", "url": "https://www.uniprot.org/uniprotkb/Q13426" }, { "database": "PubMed", "id": "25597996", "url": "https://pubmed.ncbi.nlm.nih.gov/25597996" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" } ], "uniprot_canonical_ac": "Q13426-1" }, { "start_pos": 132, "end_pos": 132, "sequence_org": "S", "sequence_mut": "A", "comment": "In 6A mutant; abolished phosphorylation; does not affect ability to repair double-strand breaks (DSBs), possibly because of redundancy with XRCC4 phosphorylation sites; when associated with A-203, A-245, A-251, A-263 and A-266. In XLF-Ala mutant; abolished phosphorylation by PRKDC; does not affect ability to bridge DNA when associated with XRCC4 phosphorylation-defective mutant; when associated with A-203, A-245 and A-251.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" }, { "database": "PubMed", "id": "18644470", "url": "https://pubmed.ncbi.nlm.nih.gov/18644470" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 132, "end_pos": 132, "sequence_org": "S", "sequence_mut": "D", "comment": "In XLF-Asp mutant; phospho-mimetic mutant; abolished ability to bridge DNA when associated with XRCC4 phospho-mimetic mutant; when associated with D-203, D-245 and D-251.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 203, "end_pos": 203, "sequence_org": "S", "sequence_mut": "A", "comment": "In 6A mutant; abolished phosphorylation; does not affect ability to repair double-strand breaks (DSBs), possibly because of redundancy with XRCC4 phosphorylation sites; when associated with A-132, A-245, A-251, A-263 and A-266. In XLF-Ala mutant; abolished phosphorylation by PRKDC; does not affect ability to bridge DNA when associated with XRCC4 phosphorylation-defective mutant; when associated with A-132, A-245 and A-251.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "22228831", "url": "https://pubmed.ncbi.nlm.nih.gov/22228831" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" }, { "database": "PubMed", "id": "18644470", "url": "https://pubmed.ncbi.nlm.nih.gov/18644470" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 203, "end_pos": 203, "sequence_org": "S", "sequence_mut": "D", "comment": "In XLF-Asp mutant; phospho-mimetic mutant; abolished ability to bridge DNA when associated with XRCC4 phospho-mimetic mutant; when associated with D-132, D-245 and D-251.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 245, "end_pos": 245, "sequence_org": "S", "sequence_mut": "A", "comment": "In 6A mutant; abolished phosphorylation; does not affect ability to repair double-strand breaks (DSBs), possibly because of redundancy with XRCC4 phosphorylation sites; when associated with A-132, A-203, A-251, A-263 and A-266. In XLF-Ala mutant; abolished phosphorylation by PRKDC; does not affect ability to bridge DNA when associated with XRCC4 phosphorylation-defective mutant; when associated with A-132, A-203 and A-251.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "22228831", "url": "https://pubmed.ncbi.nlm.nih.gov/22228831" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" }, { "database": "PubMed", "id": "18644470", "url": "https://pubmed.ncbi.nlm.nih.gov/18644470" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 245, "end_pos": 245, "sequence_org": "S", "sequence_mut": "D", "comment": "In XLF-Asp mutant; phospho-mimetic mutant; abolished ability to bridge DNA when associated with XRCC4 phospho-mimetic mutant; when associated with D-132, D-203 and D-251.", "evidence": [ { "database": "UniProtKB", "id": "Q9H9Q4", "url": "https://www.uniprot.org/uniprotkb/Q9H9Q4" }, { "database": "PubMed", "id": "28500754", "url": "https://pubmed.ncbi.nlm.nih.gov/28500754" } ], "uniprot_canonical_ac": "Q9H9Q4-1" }, { "start_pos": 251, "end_pos": 251, "sequence_org": "S", "sequence_mut": "A", "comment": "In 6A mutant; abolished phosphorylation; does not affect ability to repair double-strand breaks (DSBs), possibly because of redundancy with XRCC4 phosphorylation sites; when associated with A-132, A-203, A-245, A-263 and A-266. 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"count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The RNA binding protein Sam68 is acetylated in tumor cell lines, and its acetylation correlates with enhanced RNA binding activity.", "journal": "Oncogene", "date": "2004", "authors": "Babic I, Jakymiw A, Fujita DJ", "reference": { "type": "PubMed", "id": "15021911", "url": "https://pubmed.ncbi.nlm.nih.gov/15021911" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q07666-1", "protein_name": "KH domain-containing, RNA-binding, signal transduction-associated protein 1", "gene_name": "KHDRBS1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q07666", "url": "https://www.uniprot.org/uniprotkb/Q07666" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.15021911", 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[] } ] }, { "title": "Localization of nucleoporin Tpr to the nuclear pore complex is essential for Tpr mediated regulation of the export of unspliced RNA.", "journal": "PloS one", "date": "2012", "authors": "Rajanala Kalpana, Nandicoori Vinay Kumar", "reference": { "type": "PubMed", "id": "22253824", "url": "https://pubmed.ncbi.nlm.nih.gov/22253824" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q07666-1", "protein_name": "KH domain-containing, RNA-binding, signal transduction-associated protein 1", "gene_name": "KHDRBS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49790-1", "protein_name": "Nuclear pore complex protein Nup153", "gene_name": "NUP153", "tax_name": "Human" }, { "uniprot_canonical_ac": "P12270-1", "protein_name": "Nucleoprotein TPR", "gene_name": "TPR", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q07666", "url": 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SAM68-mediated BCL-X alternative splicing and apoptosis.", "journal": "EMBO Rep.", "date": "2014", "authors": "Bielli Pamela, Bus\u00e0 Roberta, Di Stasi Savino M, Munoz Manuel J, Botti Flavia, Kornblihtt Alberto R, Sette Claudio", "reference": { "type": "PubMed", "id": "24514149", "url": "https://pubmed.ncbi.nlm.nih.gov/24514149" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q07666-1", "protein_name": "KH domain-containing, RNA-binding, signal transduction-associated protein 1", "gene_name": "KHDRBS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O95365-1", "protein_name": "Zinc finger and BTB domain-containing protein 7A", "gene_name": "ZBTB7A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q07666", "url": "https://www.uniprot.org/uniprotkb/Q07666" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": 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