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[] } ] }, { "title": "FE65 as a link between VLDLR and APP to regulate their trafficking and processing.", "journal": "Molecular neurodegeneration", "date": "2012", "authors": "Dumanis SB, Chamberlain KA, Jin Sohn Y, Jin Lee Y, Guenette SY, Suzuki T, Mathews PM, Pak DTs, Rebeck GW, Suh YH, Park HS, Hoe HS", "reference": { "type": "PubMed", "id": "22429478", "url": "https://pubmed.ncbi.nlm.nih.gov/22429478" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P46933-1", "protein_name": "Amyloid beta precursor protein binding family B member 1", "gene_name": "Apbb1", "tax_name": "Rat" } ], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P46933", "url": "https://www.uniprot.org/uniprotkb/P46933" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "record_id": "pubmed.22429478", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], 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Biol. Chem.", "date": "2005", "authors": "Dutertre S, Nicke A, Lewis RJ", "reference": { "type": "PubMed", "id": "15929983", "url": "https://pubmed.ncbi.nlm.nih.gov/15929983" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P09483-1", "protein_name": "Neuronal acetylcholine receptor subunit alpha-4", "gene_name": "Chrna4", "tax_name": "Rat" }, { "uniprot_canonical_ac": "P04757-1", "protein_name": "Neuronal acetylcholine receptor subunit alpha-3", "gene_name": "Chrna3", "tax_name": "Rat" }, { "uniprot_canonical_ac": "P12390-1", "protein_name": "Neuronal acetylcholine receptor subunit beta-2", "gene_name": "Chrnb2", "tax_name": "Rat" } ], "species": [ { "name": "Rattus norvegicus", "taxid": 10116, "evidence": [ { "database": "UniProtKB", "id": "P09483", "url": "https://www.uniprot.org/uniprotkb/P09483" } ], "common_name": "Rat", "glygen_name": "Rat", "reference_species": "Rattus norvegicus [10116]" } ], "mutagenesis": [ { "start_pos": 118, "end_pos": 118, "sequence_org": "L", "sequence_mut": "Q", "comment": "40-fold, 165-fold, and 300-fold decrease in inhibition of alpha-3-beta-2(L118Q) nAChR by alpha-conotoxins PnIA, GID and MII, respectively.", "evidence": [ { "database": "UniProtKB", "id": "P12390", "url": "https://www.uniprot.org/uniprotkb/P12390" }, { "database": "PubMed", "id": "15929983", "url": "https://pubmed.ncbi.nlm.nih.gov/15929983" } ], "uniprot_canonical_ac": "P12390-1" }, { "start_pos": 135, "end_pos": 135, "sequence_org": "V", "sequence_mut": "A", "comment": "Very small decrease or no change in inhibition of alpha-3-beta-2(V135A) nAChR by alpha-conotoxins PnIA, GID and MII.", "evidence": [ { "database": "UniProtKB", "id": "P12390", "url": "https://www.uniprot.org/uniprotkb/P12390" }, { "database": "PubMed", "id": "15929983", "url": "https://pubmed.ncbi.nlm.nih.gov/15929983" } ], "uniprot_canonical_ac": "P12390-1" }, { "start_pos": 135, "end_pos": 135, "sequence_org": "V", "sequence_mut": "G", "comment": "No change in 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