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"journal": "Cancer immunology research", "date": "2022-10-04", "authors": "Thudium Kent, Selby Mark, Zorn Julie A, Rak Gregory, Wang Xi-Tao, Bunch Roderick Todd, Hogan Jason M, Strop Pavel, Korman Alan J", "reference": { "type": "PubMed", "id": "35981087", "url": "https://pubmed.ncbi.nlm.nih.gov/35981087" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P18627-1", "protein_name": "Lymphocyte activation gene 3 protein", "gene_name": "LAG3", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P18627", "url": "https://www.uniprot.org/uniprotkb/P18627" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.35981087", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", 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Physiol. 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"count": 0 } ], "sort_fields": [] } ] }, { "title": "CXCL17 activates three MAS-related G protein-coupled receptors independently of its conserved C-terminal fragment.", "journal": "Archives of biochemistry and biophysics", "date": "2026-01", "authors": "Hu Wen-Feng, Wang Juan-Juan, Yu Jie, Liu Ya-Li, Xu Zeng-Guang, Guo Zhan-Yun", "reference": { "type": "PubMed", "id": "41167449", "url": "https://pubmed.ncbi.nlm.nih.gov/41167449" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P04201-1", "protein_name": "Proto-oncogene Mas", "gene_name": "MAS1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96LB1-1", "protein_name": "Mas-related G protein-coupled receptor member X2", "gene_name": "MRGPRX2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q96LB2-1", "protein_name": "Mas-related G protein-coupled receptor member X1", "gene_name": "MRGPRX1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P04201", "url": "https://www.uniprot.org/uniprotkb/P04201" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.41167449", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation.", "journal": "Nat. Struct. Biol.", "date": "2001", "authors": "Thunnissen MM, Nordlund P, Haeggstrom JZ", "reference": { "type": "PubMed", "id": "11175901", "url": "https://pubmed.ncbi.nlm.nih.gov/11175901" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P09960-1", "protein_name": "Leukotriene A-4 hydrolase", "gene_name": "LTA4H", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P09960", "url": "https://www.uniprot.org/uniprotkb/P09960" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.11175901", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Leukotriene A4 hydrolase/aminopeptidase. Glutamate 271 is a catalytic residue with specific roles in two distinct enzyme mechanisms.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Rudberg PC, Tholander F, Thunnissen MM, Haeggstrom JZ", "reference": { "type": "PubMed", "id": "11675384", "url": "https://pubmed.ncbi.nlm.nih.gov/11675384" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P09960-1", "protein_name": "Leukotriene A-4 hydrolase", "gene_name": "LTA4H", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P09960", "url": "https://www.uniprot.org/uniprotkb/P09960" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 137, "end_pos": 137, "sequence_org": "Q", "sequence_mut": "A", "comment": "No loss of activity.", "evidence": [ { "database": "UniProtKB", "id": "P09960", "url": 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"start_pos": 270, "end_pos": 270, "sequence_org": "G", "sequence_mut": "A", "comment": "No loss of activity.", "evidence": [ { "database": "UniProtKB", "id": "P09960", "url": "https://www.uniprot.org/uniprotkb/P09960" }, { "database": "PubMed", "id": "11675384", "url": "https://pubmed.ncbi.nlm.nih.gov/11675384" } ], "uniprot_canonical_ac": "P09960-1" }, { "start_pos": 271, "end_pos": 271, "sequence_org": "M", "sequence_mut": "L", "comment": "No loss of activity.", "evidence": [ { "database": "UniProtKB", "id": "P09960", "url": "https://www.uniprot.org/uniprotkb/P09960" }, { "database": "PubMed", "id": "11675384", "url": "https://pubmed.ncbi.nlm.nih.gov/11675384" } ], "uniprot_canonical_ac": "P09960-1" }, { "start_pos": 272, "end_pos": 272, "sequence_org": "E", "sequence_mut": "A", "comment": "Complete loss of epoxide hydrolase activity and aminopeptidase activity.", "evidence": [ { "database": "UniProtKB", "id": "P09960", "url": "https://www.uniprot.org/uniprotkb/P09960" }, { "database": "PubMed", "id": "11675384", "url": "https://pubmed.ncbi.nlm.nih.gov/11675384" } ], "uniprot_canonical_ac": "P09960-1" }, { "start_pos": 272, "end_pos": 272, "sequence_org": "E", "sequence_mut": "D", "comment": "Complete loss of epoxide hydrolase activity and aminopeptidase activity.", "evidence": [ { "database": "UniProtKB", "id": "P09960", "url": "https://www.uniprot.org/uniprotkb/P09960" }, { "database": "PubMed", "id": "11675384", "url": "https://pubmed.ncbi.nlm.nih.gov/11675384" } ], "uniprot_canonical_ac": "P09960-1" }, { "start_pos": 272, "end_pos": 272, "sequence_org": "E", "sequence_mut": "Q", "comment": "Loss of LTA4 hydrolase activity, and aminopeptidase activity strongly impaired.", "evidence": [ { "database": "UniProtKB", "id": "P09960", "url": "https://www.uniprot.org/uniprotkb/P09960" }, { "database": "PubMed", "id": "11675384", "url": "https://pubmed.ncbi.nlm.nih.gov/11675384" } ], "uniprot_canonical_ac": "P09960-1" }, { "start_pos": 273, "end_pos": 273, "sequence_org": "N", "sequence_mut": "A", "comment": "No loss of epoxide hydrolase activity and aminopeptidase activity.", "evidence": [ { "database": "UniProtKB", "id": "P09960", "url": "https://www.uniprot.org/uniprotkb/P09960" }, { "database": "PubMed", "id": "11675384", "url": "https://pubmed.ncbi.nlm.nih.gov/11675384" } ], "uniprot_canonical_ac": "P09960-1" } ], "record_id": "pubmed.11675384", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Leukotriene A4 hydrolase: selective abrogation of leukotriene B4 formation by mutation of aspartic acid 375.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2002", "authors": "Rudberg PC, Tholander F, Thunnissen MM, Samuelsson B, Haeggstrom JZ", "reference": { "type": "PubMed", "id": "11917124", "url": "https://pubmed.ncbi.nlm.nih.gov/11917124" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P09960-1", "protein_name": "Leukotriene A-4 hydrolase", "gene_name": "LTA4H", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P09960", "url": "https://www.uniprot.org/uniprotkb/P09960" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 135, "end_pos": 135, "sequence_org": "Q", "sequence_mut": "A", "comment": "Srongly increased epoxide hydrolase activity.", "evidence": [ { "database": "UniProtKB", "id": "P09960", "url": "https://www.uniprot.org/uniprotkb/P09960" }, { "database": "PubMed", "id": "11917124", "url": "https://pubmed.ncbi.nlm.nih.gov/11917124" } ], "uniprot_canonical_ac": "P09960-1" }, { "start_pos": 135, "end_pos": 135, "sequence_org": "Q", "sequence_mut": "A", "comment": "Strongly reduced aminopeptidase activity. Strongly decreased affinity for leukotriene. Abolishes epoxide hydrolase activity.", "evidence": [ { "database": "UniProtKB", "id": "P09960", "url": "https://www.uniprot.org/uniprotkb/P09960" }, { "database": "PubMed", "id": "11917124", "url": "https://pubmed.ncbi.nlm.nih.gov/11917124" } ], "uniprot_canonical_ac": "P09960-1" }, { "start_pos": 135, "end_pos": 135, "sequence_org": "Q", "sequence_mut": "L", "comment": "Srongly increased epoxide hydrolase activity.", "evidence": [ { "database": "UniProtKB", "id": "P09960", "url": "https://www.uniprot.org/uniprotkb/P09960" }, { "database": "PubMed", "id": "11917124", "url": "https://pubmed.ncbi.nlm.nih.gov/11917124" } ], "uniprot_canonical_ac": "P09960-1" }, { "start_pos": 140, "end_pos": 140, "sequence_org": "H", "sequence_mut": "Q", "comment": "Aminopeptidase activity almost absent, but keeps LTA4 activity.", "evidence": [ { "database": "UniProtKB", "id": "P09960", "url": "https://www.uniprot.org/uniprotkb/P09960" }, { "database": "PubMed", "id": "11917124", "url": "https://pubmed.ncbi.nlm.nih.gov/11917124" } ], "uniprot_canonical_ac": "P09960-1" }, { "start_pos": 372, "end_pos": 372, "sequence_org": "D", "sequence_mut": "N", "comment": "No loss of activity.", "evidence": [ { "database": "UniProtKB", "id": "P09960", "url": "https://www.uniprot.org/uniprotkb/P09960" }, { "database": "PubMed", "id": "11917124", "url": "https://pubmed.ncbi.nlm.nih.gov/11917124" } ], "uniprot_canonical_ac": "P09960-1" }, { "start_pos": 374, "end_pos": 374, "sequence_org": "D", "sequence_mut": "N", "comment": "No loss of activity.", "evidence": [ { "database": "UniProtKB", "id": "P09960", "url": "https://www.uniprot.org/uniprotkb/P09960" }, { "database": "PubMed", "id": "11917124", "url": "https://pubmed.ncbi.nlm.nih.gov/11917124" } ], "uniprot_canonical_ac": "P09960-1" }, { "start_pos": 376, "end_pos": 376, "sequence_org": "D", "sequence_mut": "A", "comment": "Strongly reduced hydrolysis of peptides starting with Arg. Small effect on hydrolysis of peptides starting with Ala. Abolishes epoxide hydrolase activity.", "evidence": [ { "database": "UniProtKB", "id": "P09960", "url": "https://www.uniprot.org/uniprotkb/P09960" }, { "database": "PubMed", "id": "18804029", "url": "https://pubmed.ncbi.nlm.nih.gov/18804029" }, { "database": "PubMed", "id": "11917124", "url": "https://pubmed.ncbi.nlm.nih.gov/11917124" } ], "uniprot_canonical_ac": "P09960-1" }, { "start_pos": 376, "end_pos": 376, "sequence_org": "D", "sequence_mut": "E", "comment": "Strongly reduced aminopeptidase activity. 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity.", "journal": "Nature genetics", "date": "2018", "authors": "Siljee JE, Wang Y, Bernard AA, Ersoy BA, Zhang S, Marley A, Von Zastrow M, Reiter JF, Vaisse C", "reference": { "type": "PubMed", "id": "29311635", "url": "https://pubmed.ncbi.nlm.nih.gov/29311635" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P32245-1", "protein_name": "Melanocortin receptor 4", "gene_name": "MC4R", "tax_name": "Human" }, { "uniprot_canonical_ac": "O60266-1", "protein_name": "Adenylate cyclase type 3", "gene_name": "ADCY3", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P32245", "url": "https://www.uniprot.org/uniprotkb/P32245" } ], "common_name": "Human", 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