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"AIP1 recruits phosphatase PP2A to ASK1 in tumor necrosis factor-induced ASK1-JNK activation.", "journal": "Circulation research", "date": "2008", "authors": "Min W, Lin Y, Tang S, Yu L, Zhang H, Wan T, Luhn T, Fu H, Chen H", "reference": { "type": "PubMed", "id": "18292600", "url": "https://pubmed.ncbi.nlm.nih.gov/18292600" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P67776-1", "protein_name": "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform", "gene_name": "PPP2CA", "tax_name": "Pig" }, { "uniprot_canonical_ac": "Q5VWQ8-1", "protein_name": "Disabled homolog 2-interacting protein", "gene_name": "DAB2IP", "tax_name": "Human" } ], "species": [ { "name": "Sus scrofa", "taxid": 9823, "evidence": [ { "database": "UniProtKB", "id": "P67776", "url": "https://www.uniprot.org/uniprotkb/P67776" } ], "common_name": "Pig", "glygen_name": "Pig", "reference_species": "Sus scrofa [9823]" } ], "mutagenesis": [ { "start_pos": 728, "end_pos": 728, "sequence_org": "S", "sequence_mut": "A", "comment": "Inhibits phosphorylation and TNF-induced MAP3K5 dephosphorylation. Reduces interaction with 14-3-3 proteins, AKT1, a regulatory p85 subunit, MAP3K5, RIPK1, TRAF2 and TNF-induced MAP3K5-JNK signaling and apoptosis. Reduces RAS activity. Does not reduce GSK3B-induced beta catenin-mediated transcription activity. Does not reduce NF-kappa-B activity, cell invasion, epithelial-to-mesenchymal transition (EMT) and tumor development. Does not suppress tumor development; when associated with R-413.", "evidence": [ { "database": "UniProtKB", "id": "Q5VWQ8", "url": "https://www.uniprot.org/uniprotkb/Q5VWQ8" }, { "database": "PubMed", "id": "20154697", "url": "https://pubmed.ncbi.nlm.nih.gov/20154697" }, { "database": "PubMed", "id": "19903888", "url": "https://pubmed.ncbi.nlm.nih.gov/19903888" }, { "database": "PubMed", "id": "18292600", "url": "https://pubmed.ncbi.nlm.nih.gov/18292600" }, { "database": "PubMed", "id": "17389591", "url": "https://pubmed.ncbi.nlm.nih.gov/17389591" } ], "uniprot_canonical_ac": "Q5VWQ8-1" } ], "record_id": "pubmed.18292600", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } 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"evidence": [ { "database": "UniProtKB", "id": "P67776", "url": "https://www.uniprot.org/uniprotkb/P67776" } ], "common_name": "Pig", "glygen_name": "Pig", "reference_species": "Sus scrofa [9823]" } ], "record_id": "pubmed.19109948", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { 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"Pig MAP/ITIH4 and haptoglobin are interleukin-6-dependent acute-phase plasma proteins in porcine primary cultured hepatocytes.", "journal": "European journal of biochemistry", "date": "2000-03", "authors": "Gonz\u00e1lez-Ram\u00f3n N, Hoebe K, Alava M A, Van Leengoed L, Pi\u00f1eiro M, Carmona S, Iturralde M, Lampreave F, Pi\u00f1eiro A", "reference": { "type": "PubMed", "id": "10712621", "url": "https://pubmed.ncbi.nlm.nih.gov/10712621" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P79263-1", "protein_name": "Inter-alpha-trypsin inhibitor heavy chain H4", "gene_name": "ITIH4", "tax_name": "Pig" } ], "species": [ { "name": "Sus scrofa", "taxid": 9823, "evidence": [ { "database": "UniProtKB", "id": "P79263", "url": "https://www.uniprot.org/uniprotkb/P79263" } ], "common_name": "Pig", "glygen_name": "Pig", "reference_species": "Sus scrofa [9823]" } ], "record_id": "pubmed.10712621", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], 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}, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Isolation and characterization of the promoter and partial enhancer region of the porcine inter-alpha-trypsin inhibitor heavy chain 4 gene.", "journal": "Clinical and diagnostic laboratory immunology", "date": "2005-11", "authors": "Harraghy Niamh, Mitchell Timothy J", "reference": { "type": "PubMed", "id": "16275952", "url": "https://pubmed.ncbi.nlm.nih.gov/16275952" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P79263-1", "protein_name": "Inter-alpha-trypsin inhibitor heavy chain H4", "gene_name": "ITIH4", "tax_name": "Pig" } ], "species": [ { "name": "Sus scrofa", "taxid": 9823, "evidence": [ { "database": "UniProtKB", "id": "P79263", "url": "https://www.uniprot.org/uniprotkb/P79263" } ], "common_name": "Pig", "glygen_name": "Pig", "reference_species": "Sus scrofa [9823]" } ], "record_id": "pubmed.16275952", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", 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"count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Molecular biology of circulatory shock. Part II. Expression of four groups of hepatic genes is enhanced after resuscitation from cardiogenic shock.", "journal": "Surgery", "date": "1990", "authors": "Buchman T G, Cabin D E, Vickers S, Deutschman C S, Delgado E, Sussman M M, Bulkley G B", "reference": { "type": "PubMed", "id": "1697703", "url": "https://pubmed.ncbi.nlm.nih.gov/1697703" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P79263-1", "protein_name": "Inter-alpha-trypsin inhibitor heavy chain H4", "gene_name": "ITIH4", "tax_name": "Pig" }, { "uniprot_canonical_ac": "P34934-1", "protein_name": "Heat shock 70 kDa protein", "gene_name": "", "tax_name": "Pig" } ], "species": [ { "name": "Sus scrofa", "taxid": 9823, "evidence": [ { "database": "UniProtKB", "id": "P79263", "url": "https://www.uniprot.org/uniprotkb/P79263" } ], "common_name": "Pig", "glygen_name": "Pig", "reference_species": "Sus scrofa [9823]" } ], "record_id": "pubmed.1697703", "abstract": "", "glycosylation": [], "mutagenesis": 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Genome", "date": "1997", "authors": "Meijerink E, Fries R, V\u00f6geli P, Masabanda J, Wigger G, Stricker C, Neuenschwander S, Bertschinger H U, Stranzinger G", "reference": { "type": "PubMed", "id": "9321466", "url": "https://pubmed.ncbi.nlm.nih.gov/9321466" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q10982-1", "protein_name": "Galactoside alpha-(1,2)-fucosyltransferase 2", "gene_name": "FUT2", "tax_name": "Pig" }, { "uniprot_canonical_ac": "Q29043-1", "protein_name": "Galactoside alpha-(1,2)-fucosyltransferase 1", "gene_name": "FUT1", "tax_name": "Pig" } ], "species": [ { "name": "Sus scrofa", "taxid": 9823, "evidence": [ { "database": "UniProtKB", "id": "Q10982", "url": "https://www.uniprot.org/uniprotkb/Q10982" } ], "common_name": "Pig", "glygen_name": "Pig", "reference_species": "Sus scrofa [9823]" } ], "record_id": "pubmed.9321466", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], 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"Circulation research", "date": "2009-07-31", "authors": "Martin Kenneth, Weiss Sharon, Metharom Pat, Schmeckpeper Jeffrey, Hynes Brian, O'Sullivan John, Caplice Noel", "reference": { "type": "PubMed", "id": "19574550", "url": "https://pubmed.ncbi.nlm.nih.gov/19574550" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q19AZ8-1", "protein_name": "Prothrombin", "gene_name": "F2", "tax_name": "Pig" }, { "uniprot_canonical_ac": "I3LVS7-1", "protein_name": "Ras homolog family member A", "gene_name": "RHOA", "tax_name": "Pig" }, { "uniprot_canonical_ac": "Q7YR76-1", "protein_name": "Myocardin", "gene_name": "MYOCD", "tax_name": "Pig" } ], "species": [ { "name": "Sus scrofa", "taxid": 9823, "evidence": [ { "database": "UniProtKB", "id": "Q19AZ8", "url": "https://www.uniprot.org/uniprotkb/Q19AZ8" } ], "common_name": "Pig", "glygen_name": "Pig", "reference_species": "Sus scrofa [9823]" } ], "record_id": "pubmed.19574550", "abstract": "", "glycosylation": [], 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