[ { "title": "The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.", "journal": "Cell", "date": "2002-10-18", "authors": "van de Wetering Marc, Sancho Elena, Verweij Cornelis, de Lau Wim, Oving Irma, Hurlstone Adam, van der Horn Karin, Batlle Eduard, Coudreuse Damien, Haramis Anna Pavlina, Tjon-Pon-Fong Menno, Moerer Petra, van den Born Maaike, Soete Gwen, Pals Steven, Eilers Martin, Medema Rene, Clevers Hans", "reference": { "type": "PubMed", "id": "12408868", "url": "https://pubmed.ncbi.nlm.nih.gov/12408868" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9NQB0-1", "protein_name": "Transcription factor 7-like 2", "gene_name": "TCF7L2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NQB0", "url": "https://www.uniprot.org/uniprotkb/Q9NQB0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.12408868", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Identification of a promoter-specific transcriptional activation domain at the C-terminus of the Wnt effector protein T-cell factor 4.", "journal": "J. Biol. Chem.", "date": "2003", "authors": "Hecht A, Stemmler MP", "reference": { "type": "PubMed", "id": "12446687", "url": "https://pubmed.ncbi.nlm.nih.gov/12446687" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9NQB0-1", "protein_name": "Transcription factor 7-like 2", "gene_name": "TCF7L2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P27782-1", "protein_name": "Lymphoid enhancer-binding factor 1", "gene_name": "Lef1", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q09472-1", "protein_name": "Histone acetyltransferase p300", "gene_name": "EP300", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NQB0", "url": "https://www.uniprot.org/uniprotkb/Q9NQB0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.12446687", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Sumoylation is involved in beta-catenin-dependent activation of Tcf-4.", "journal": "The EMBO journal", "date": "2003", "authors": "Yamamoto H, Ihara M, Matsuura Y, Kikuchi A", "reference": { "type": "PubMed", "id": "12727872", "url": "https://pubmed.ncbi.nlm.nih.gov/12727872" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9NQB0-1", "protein_name": "Transcription factor 7-like 2", "gene_name": "TCF7L2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q8N2W9-1", "protein_name": "E3 SUMO-protein ligase PIAS4", "gene_name": "PIAS4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NQB0", "url": "https://www.uniprot.org/uniprotkb/Q9NQB0" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 320, "end_pos": 320, "sequence_org": "K", "sequence_mut": "R", "comment": "Loss of sumoylation. No effect on localization to nuclear bodies.", "evidence": [ { "database": "UniProtKB", "id": "Q9NQB0", "url": "https://www.uniprot.org/uniprotkb/Q9NQB0" }, { "database": "PubMed", "id": "12727872", "url": "https://pubmed.ncbi.nlm.nih.gov/12727872" } ], "uniprot_canonical_ac": "Q9NQB0-1" }, { "start_pos": 322, "end_pos": 322, "sequence_org": "E", "sequence_mut": "A", "comment": "Loss of sumoylation.", "evidence": [ { "database": "UniProtKB", "id": "Q9NQB0", "url": "https://www.uniprot.org/uniprotkb/Q9NQB0" }, { "database": "PubMed", "id": "12727872", "url": "https://pubmed.ncbi.nlm.nih.gov/12727872" } ], "uniprot_canonical_ac": "Q9NQB0-1" }, { "start_pos": 128, "end_pos": 128, "sequence_org": "K", "sequence_mut": "R", "comment": "Some loss of sumoylation.", "evidence": [ { "database": "UniProtKB", "id": "Q8N2W9", "url": "https://www.uniprot.org/uniprotkb/Q8N2W9" }, { "database": "PubMed", "id": "12727872", "url": "https://pubmed.ncbi.nlm.nih.gov/12727872" }, { "database": "PubMed", "id": "15831457", "url": "https://pubmed.ncbi.nlm.nih.gov/15831457" } ], "uniprot_canonical_ac": "Q8N2W9-1" }, { "start_pos": 342, "end_pos": 342, "sequence_org": "C", "sequence_mut": "A", "comment": "Abolished SUMO ligase activity. Inhibits TCF4 sumoylation. Inhibits beta-catenin-mediated TCF7L2/TCF4 activity. No colocalization with TCF7L2/TCF4 in nuclear punctate structures; when associated with A-347.", "evidence": [ { "database": "UniProtKB", "id": "Q8N2W9", "url": "https://www.uniprot.org/uniprotkb/Q8N2W9" }, { "database": "PubMed", "id": "12727872", "url": "https://pubmed.ncbi.nlm.nih.gov/12727872" }, { "database": "PubMed", "id": "35013556", "url": "https://pubmed.ncbi.nlm.nih.gov/35013556" } ], "uniprot_canonical_ac": "Q8N2W9-1" }, { "start_pos": 347, "end_pos": 347, "sequence_org": "C", "sequence_mut": "A", "comment": "Inhibits TCF4 sumoylation. Inhibits beta-catenin-mediated TCF7L2/TCF4 activity. No colocalization with TCF7L2/TCF4 in nuclear punctate structures; when associated with A-342. AR- and STAT1-binding.", "evidence": [ { "database": "UniProtKB", "id": "Q8N2W9", "url": "https://www.uniprot.org/uniprotkb/Q8N2W9" }, { "database": "PubMed", "id": "12727872", "url": "https://pubmed.ncbi.nlm.nih.gov/12727872" } ], "uniprot_canonical_ac": "Q8N2W9-1" }, { "start_pos": 35, "end_pos": 35, "sequence_org": "K", "sequence_mut": "R", "comment": "Complete loss of sumoylation. No enhancement of TCF4 sumoylation. No effect on interaction with TCF4. 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Genet.", "date": "2006", "authors": "Grant Struan F A, Thorleifsson Gudmar, Reynisdottir Inga, Benediktsson Rafn, Manolescu Andrei, Sainz Jesus, Helgason Agnar, Stefansson Hreinn, Emilsson Valur, Helgadottir Anna, Styrkarsdottir Unnur, Magnusson Kristinn P, Walters G Bragi, Palsdottir Ebba, Jonsdottir Thorbjorg, Gudmundsdottir Thorunn, Gylfason Arnaldur, Saemundsdottir Jona, Wilensky Robert L, Reilly Muredach P, Rader Daniel J, Bagger Yu, Christiansen Claus, Gudnason Vilmundur, Sigurdsson Gunnar, Thorsteinsdottir Unnur, Gulcher Jeffrey R, Kong Augustine, Stefansson Kari", "reference": { "type": "PubMed", "id": "16415884", "url": "https://pubmed.ncbi.nlm.nih.gov/16415884" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9NQB0-1", "protein_name": "Transcription factor 7-like 2", "gene_name": "TCF7L2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NQB0", "url": 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"o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "A new type of plasma prekallikrein deficiency associated with homozygosity for Gly104Arg and Asn124Ser in apple domain 2 of the heavy-chain region.", "journal": "European journal of haematology", "date": "2007", "authors": "Katsuda I, Maruyama F, Ezaki K, Sawamura T, Ichihara Y", "reference": { "type": "PubMed", "id": "17598838", "url": "https://pubmed.ncbi.nlm.nih.gov/17598838" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P03952-1", "protein_name": "Plasma kallikrein", "gene_name": "KLKB1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P03952", "url": "https://www.uniprot.org/uniprotkb/P03952" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.17598838", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], 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Genetic and structural evidence suggesting that the P12-region contains critical determinants of serine protease inhibitor/substrate status.", "journal": "The Journal of biological chemistry", "date": "1991", "authors": "Skriver K, Wikoff WR, Patston PA, Tausk F, Schapira M, Kaplan AP, Bock SC", "reference": { "type": "PubMed", "id": "2026621", "url": "https://pubmed.ncbi.nlm.nih.gov/2026621" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P03952-1", "protein_name": "Plasma kallikrein", "gene_name": "KLKB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05155-1", "protein_name": "Plasma protease C1 inhibitor", "gene_name": "SERPING1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00748-1", "protein_name": "Coagulation factor XII", "gene_name": "F12", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P03952", "url": "https://www.uniprot.org/uniprotkb/P03952" } ], 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"glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Type II hereditary angioneurotic edema that may result from a single nucleotide change in the codon for alanine-436 in the C1 inhibitor gene.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1990", "authors": "Levy NJ, Ramesh N, Cicardi M, Harrison RA, Davis AE 3rd", "reference": { "type": "PubMed", "id": "2296585", "url": "https://pubmed.ncbi.nlm.nih.gov/2296585" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P03952-1", "protein_name": "Plasma kallikrein", "gene_name": "KLKB1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P05155-1", "protein_name": "Plasma protease C1 inhibitor", "gene_name": "SERPING1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00748-1", "protein_name": "Coagulation factor XII", "gene_name": "F12", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P03952", "url": "https://www.uniprot.org/uniprotkb/P03952" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], 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Laat B, Joosten L, Netea MG, van der Ven AJ, de Groot PG, de Mast Q, Roest M", "reference": { "type": "PubMed", "id": "34532976", "url": "https://pubmed.ncbi.nlm.nih.gov/34532976" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P03952-1", "protein_name": "Plasma kallikrein", "gene_name": "KLKB1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P03952", "url": "https://www.uniprot.org/uniprotkb/P03952" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.34532976", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", 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Biol.", "date": "1999", "authors": "Hsieh YJ, Wang Z, Kovelman R, Roeder RG", "reference": { "type": "PubMed", "id": "10373544", "url": "https://pubmed.ncbi.nlm.nih.gov/10373544" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9Y5Q8-1", "protein_name": "General transcription factor 3C polypeptide 5", "gene_name": "GTF3C5", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y5Q9-1", "protein_name": "General transcription factor 3C polypeptide 3", "gene_name": "GTF3C3", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9Y5Q8", "url": "https://www.uniprot.org/uniprotkb/Q9Y5Q8" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10373544", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", 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Biophys. 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], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese Europeans: the NUGENOB study.", "journal": "Obesity (Silver Spring, Md.)", "date": "2010", "authors": "Corpeleijn E, Petersen L, Holst C, Saris WH, Astrup A, Langin D, MacDonald I, Martinez JA, Oppert JM, Polak J, Pedersen O, Froguel P, Arner P, Sorensen TI, Blaak EE", "reference": { "type": "PubMed", "id": "19876004", "url": "https://pubmed.ncbi.nlm.nih.gov/19876004" }, "referenced_glycans": [], 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