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        "title": "Formation of a uniquely stable type I interferon receptor complex by interferon beta is dependent upon particular interactions between interferon beta and its receptor and independent of tyrosine phosphorylation.",
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    {
        "title": "Interferon signaling is dependent on specific tyrosines located within the intracellular domain of IFNAR2c. Expression of IFNAR2c tyrosine mutants in U5A cells.",
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        "authors": "Wagner TC, Velichko S, Vogel D, Rani MR, Leung S, Ransohoff RM, Stark GR, Perez HD, Croze E",
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                "end_pos": 316,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-318; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-318 and F-337.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P48551",
                        "url": "https://www.uniprot.org/uniprotkb/P48551"
                    },
                    {
                        "database": "PubMed",
                        "id": "12105218",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12105218"
                    },
                    {
                        "database": "PubMed",
                        "id": "11682488",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11682488"
                    }
                ],
                "uniprot_canonical_ac": "P48551-1"
            },
            {
                "start_pos": 318,
                "end_pos": 318,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316 and F-337.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P48551",
                        "url": "https://www.uniprot.org/uniprotkb/P48551"
                    },
                    {
                        "database": "PubMed",
                        "id": "12105218",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12105218"
                    },
                    {
                        "database": "PubMed",
                        "id": "11682488",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11682488"
                    }
                ],
                "uniprot_canonical_ac": "P48551-1"
            },
            {
                "start_pos": 337,
                "end_pos": 337,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316 and F-318.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P48551",
                        "url": "https://www.uniprot.org/uniprotkb/P48551"
                    },
                    {
                        "database": "PubMed",
                        "id": "12105218",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12105218"
                    },
                    {
                        "database": "PubMed",
                        "id": "11682488",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11682488"
                    }
                ],
                "uniprot_canonical_ac": "P48551-1"
            },
            {
                "start_pos": 411,
                "end_pos": 411,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318; F-337 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P48551",
                        "url": "https://www.uniprot.org/uniprotkb/P48551"
                    },
                    {
                        "database": "PubMed",
                        "id": "12105218",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12105218"
                    },
                    {
                        "database": "PubMed",
                        "id": "11682488",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11682488"
                    }
                ],
                "uniprot_canonical_ac": "P48551-1"
            },
            {
                "start_pos": 512,
                "end_pos": 512,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318; F-337 and F-411. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318 and F-411. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-411.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P48551",
                        "url": "https://www.uniprot.org/uniprotkb/P48551"
                    },
                    {
                        "database": "PubMed",
                        "id": "12105218",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12105218"
                    },
                    {
                        "database": "PubMed",
                        "id": "11682488",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11682488"
                    }
                ],
                "uniprot_canonical_ac": "P48551-1"
            }
        ],
        "phosphorylation": [
            {
                "start_pos": 337,
                "end_pos": 337,
                "kinase_uniprot_canonical_ac": "",
                "kinase_gene_name": "",
                "residue": "Tyr",
                "comment": "Phosphotyrosine",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P48551",
                        "url": "https://www.uniprot.org/uniprotkb/P48551"
                    },
                    {
                        "database": "PubMed",
                        "id": "12105218",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12105218"
                    },
                    {
                        "database": "PubMed",
                        "id": "11682488",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11682488"
                    },
                    {
                        "database": "iPTMnet",
                        "id": "P48551",
                        "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P48551"
                    }
                ],
                "site_lbl": "Tyr337",
                "uniprot_canonical_ac": "P48551-1"
            },
            {
                "start_pos": 512,
                "end_pos": 512,
                "kinase_uniprot_canonical_ac": "",
                "kinase_gene_name": "",
                "residue": "Tyr",
                "comment": "Phosphotyrosine",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P48551",
                        "url": "https://www.uniprot.org/uniprotkb/P48551"
                    },
                    {
                        "database": "PubMed",
                        "id": "11682488",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11682488"
                    },
                    {
                        "database": "PubMed",
                        "id": "12105218",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12105218"
                    },
                    {
                        "database": "iPTMnet",
                        "id": "P48551",
                        "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P48551"
                    }
                ],
                "site_lbl": "Tyr512",
                "uniprot_canonical_ac": "P48551-1"
            }
        ],
        "record_id": "pubmed.11682488",
        "abstract": "",
        "glycosylation": [],
        "snv": [],
        "glycation": [],
        "section_stats": [
            {
                "table_id": "referenced_proteins",
                "table_stats": [
                    {
                        "field": "total",
                        "count": 1
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                ],
                "sort_fields": [
                    "uniprot_canonical_ac",
                    "protein_name",
                    "gene_name",
                    "tax_name"
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            },
            {
                "table_id": "referenced_glycans",
                "table_stats": [
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                ],
                "sort_fields": []
            },
            {
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                    {
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                    {
                        "field": "n_linked_glycan_sites",
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                    {
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                    {
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                    {
                        "field": "o_linked_glycans",
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                ],
                "sort_fields": []
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            {
                "table_id": "phosphorylation",
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                ],
                "sort_fields": [
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            {
                "table_id": "glycosylation_reported",
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                ],
                "sort_fields": []
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            {
                "table_id": "glycosylation_reported_with_glycan",
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                "table_id": "glycosylation_automatic_literature_mining",
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                "sort_fields": []
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        ]
    },
    {
        "title": "STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues.",
        "journal": "The Journal of biological chemistry",
        "date": "2002",
        "authors": "Velichko S, Wagner TC, Turkson J, Jove R, Croze E",
        "reference": {
            "type": "PubMed",
            "id": "12105218",
            "url": "https://pubmed.ncbi.nlm.nih.gov/12105218"
        },
        "referenced_glycans": [],
        "referenced_proteins": [
            {
                "uniprot_canonical_ac": "P48551-1",
                "protein_name": "Interferon alpha/beta receptor 2",
                "gene_name": "IFNAR2",
                "tax_name": "Human"
            }
        ],
        "species": [
            {
                "name": "Homo sapiens",
                "taxid": 9606,
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P48551",
                        "url": "https://www.uniprot.org/uniprotkb/P48551"
                    }
                ],
                "common_name": "Human",
                "glygen_name": "Human",
                "reference_species": "Homo sapiens [9606]"
            }
        ],
        "mutagenesis": [
            {
                "start_pos": 269,
                "end_pos": 269,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-306; F-316; F-318; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-306; F-316; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-306; F-316; F-318 and F-337.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P48551",
                        "url": "https://www.uniprot.org/uniprotkb/P48551"
                    },
                    {
                        "database": "PubMed",
                        "id": "12105218",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12105218"
                    },
                    {
                        "database": "PubMed",
                        "id": "11682488",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11682488"
                    }
                ],
                "uniprot_canonical_ac": "P48551-1"
            },
            {
                "start_pos": 306,
                "end_pos": 306,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-316; F-318; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-316; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-316; F-318 and F-337.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P48551",
                        "url": "https://www.uniprot.org/uniprotkb/P48551"
                    },
                    {
                        "database": "PubMed",
                        "id": "12105218",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12105218"
                    },
                    {
                        "database": "PubMed",
                        "id": "11682488",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11682488"
                    }
                ],
                "uniprot_canonical_ac": "P48551-1"
            },
            {
                "start_pos": 316,
                "end_pos": 316,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-318; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-318 and F-337.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P48551",
                        "url": "https://www.uniprot.org/uniprotkb/P48551"
                    },
                    {
                        "database": "PubMed",
                        "id": "12105218",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12105218"
                    },
                    {
                        "database": "PubMed",
                        "id": "11682488",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11682488"
                    }
                ],
                "uniprot_canonical_ac": "P48551-1"
            },
            {
                "start_pos": 318,
                "end_pos": 318,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-337; F-411 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316 and F-337.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P48551",
                        "url": "https://www.uniprot.org/uniprotkb/P48551"
                    },
                    {
                        "database": "PubMed",
                        "id": "12105218",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12105218"
                    },
                    {
                        "database": "PubMed",
                        "id": "11682488",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11682488"
                    }
                ],
                "uniprot_canonical_ac": "P48551-1"
            },
            {
                "start_pos": 337,
                "end_pos": 337,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318; F-411 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316 and F-318.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P48551",
                        "url": "https://www.uniprot.org/uniprotkb/P48551"
                    },
                    {
                        "database": "PubMed",
                        "id": "12105218",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12105218"
                    },
                    {
                        "database": "PubMed",
                        "id": "11682488",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11682488"
                    }
                ],
                "uniprot_canonical_ac": "P48551-1"
            },
            {
                "start_pos": 411,
                "end_pos": 411,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318; F-337 and F-512. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318 and F-512. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-512.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P48551",
                        "url": "https://www.uniprot.org/uniprotkb/P48551"
                    },
                    {
                        "database": "PubMed",
                        "id": "12105218",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12105218"
                    },
                    {
                        "database": "PubMed",
                        "id": "11682488",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11682488"
                    }
                ],
                "uniprot_canonical_ac": "P48551-1"
            },
            {
                "start_pos": 512,
                "end_pos": 512,
                "sequence_org": "Y",
                "sequence_mut": "F",
                "comment": "Does not inhibit STAT1, STAT2 and STAT3 activation by IFN. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318; F-337 and F-411. Inhibits STAT1, STAT2 and STAT3 activation by IFN; when associated with F-269; F-306; F-316; F-318 and F-411. Does not inhibit STAT1, STAT2 and STAT3 activation by IFN; when associated with F-411.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P48551",
                        "url": "https://www.uniprot.org/uniprotkb/P48551"
                    },
                    {
                        "database": "PubMed",
                        "id": "12105218",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12105218"
                    },
                    {
                        "database": "PubMed",
                        "id": "11682488",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11682488"
                    }
                ],
                "uniprot_canonical_ac": "P48551-1"
            }
        ],
        "phosphorylation": [
            {
                "start_pos": 337,
                "end_pos": 337,
                "kinase_uniprot_canonical_ac": "",
                "kinase_gene_name": "",
                "residue": "Tyr",
                "comment": "Phosphotyrosine",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P48551",
                        "url": "https://www.uniprot.org/uniprotkb/P48551"
                    },
                    {
                        "database": "PubMed",
                        "id": "12105218",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12105218"
                    },
                    {
                        "database": "PubMed",
                        "id": "11682488",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11682488"
                    },
                    {
                        "database": "iPTMnet",
                        "id": "P48551",
                        "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P48551"
                    }
                ],
                "site_lbl": "Tyr337",
                "uniprot_canonical_ac": "P48551-1"
            },
            {
                "start_pos": 512,
                "end_pos": 512,
                "kinase_uniprot_canonical_ac": "",
                "kinase_gene_name": "",
                "residue": "Tyr",
                "comment": "Phosphotyrosine",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P48551",
                        "url": "https://www.uniprot.org/uniprotkb/P48551"
                    },
                    {
                        "database": "PubMed",
                        "id": "11682488",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/11682488"
                    },
                    {
                        "database": "PubMed",
                        "id": "12105218",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/12105218"
                    },
                    {
                        "database": "iPTMnet",
                        "id": "P48551",
                        "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/P48551"
                    }
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    {
        "title": "Altered keratin 17 peptide ligands inhibit in vitro proliferation of keratinocytes and T cells isolated from patients with psoriasis.",
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    {
        "title": "A novel point mutation of keratin 17 (KRT17) in a Japanese family with pachyonychia congenita type 2: an RNA-based genetic analysis using a single hair bulb.",
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    {
        "title": "Novel missense mutation of keratin in Chinese family with steatocystoma multiplex.",
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