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carbonic anhydrase VA deficiency leads to early-onset life-threatening metabolic crisis.", "journal": "Genetics in medicine : official journal of the American College of Medical Genetics", "date": "2016", "authors": "Diez-Fernandez C, Rufenacht V, Santra S, Lund AM, Santer R, Lindner M, Tangeraas T, Unsinn C, de Lonlay P, Burlina A, van Karnebeek CD, Haberle J", "reference": { "type": "PubMed", "id": "26913920", "url": "https://pubmed.ncbi.nlm.nih.gov/26913920" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P35218-1", "protein_name": "Carbonic anhydrase 5A, mitochondrial", "gene_name": "CA5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y2D0-1", "protein_name": "Carbonic anhydrase 5B, mitochondrial", "gene_name": "CA5B", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P35218", "url": "https://www.uniprot.org/uniprotkb/P35218" } ], "common_name": "Human", 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"table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Mitochondrial carbonic anhydrase VA and VB: properties and roles in health and disease.", "journal": "The Journal of physiology", "date": "2022-12-04", "authors": "Aspatwar Ashok, Supuran Claudiu T, Waheed Abdul, Sly William S, Parkkila Seppo", "reference": { "type": "PubMed", "id": "36464834", "url": "https://pubmed.ncbi.nlm.nih.gov/36464834" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P35218-1", "protein_name": "Carbonic anhydrase 5A, mitochondrial", "gene_name": "CA5A", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9QZA0-1", "protein_name": "Carbonic anhydrase 5B, mitochondrial", "gene_name": "Ca5b", "tax_name": "Mouse" }, { "uniprot_canonical_ac": "Q9Y2D0-1", "protein_name": "Carbonic anhydrase 5B, mitochondrial", "gene_name": "CA5B", "tax_name": "Human" }, { "uniprot_canonical_ac": "P23589-1", "protein_name": "Carbonic anhydrase 5A, mitochondrial", "gene_name": "Ca5a", "tax_name": "Mouse" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P35218", "url": "https://www.uniprot.org/uniprotkb/P35218" } ], "common_name": 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localization to chromosomes 16q and 16p.", "journal": "Genomics", "date": "1995", "authors": "Nagao Y, Batanian JR, Clemente MF, Sly WS", "reference": { "type": "PubMed", "id": "7490083", "url": "https://pubmed.ncbi.nlm.nih.gov/7490083" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P35218-1", "protein_name": "Carbonic anhydrase 5A, mitochondrial", "gene_name": "CA5A", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P35218", "url": "https://www.uniprot.org/uniprotkb/P35218" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.7490083", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", 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Biol. 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"field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells.", "journal": "The EMBO journal", "date": "1995", "authors": "Faucheu C, Diu A, Chan AW, Blanchet AM, Miossec C, Herve F, Collard-Dutilleul V, Gu Y, Aldape RA, Lippke JA, et al.", "reference": { "type": "PubMed", "id": "7743998", "url": "https://pubmed.ncbi.nlm.nih.gov/7743998" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P49662-1", "protein_name": "Caspase-4", "gene_name": "CASP4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P49662", "url": "https://www.uniprot.org/uniprotkb/P49662" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 258, "end_pos": 258, "sequence_org": "C", "sequence_mut": "S", "comment": "Loss of autocatalysis.", "evidence": [ { "database": "UniProtKB", "id": "P49662", "url": "https://www.uniprot.org/uniprotkb/P49662" }, { "database": "PubMed", "id": "7743998", "url": "https://pubmed.ncbi.nlm.nih.gov/7743998" } ], "uniprot_canonical_ac": "P49662-1" } ], "record_id": "pubmed.7743998", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Kamens J, Paskind M, Hugunin M, Talanian RV, Allen H, Banach D, Bump N, Hackett M, Johnston CG, Li P, et al.", "reference": { "type": "PubMed", "id": "7797510", "url": "https://pubmed.ncbi.nlm.nih.gov/7797510" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P49662-1", "protein_name": "Caspase-4", "gene_name": "CASP4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P49662", "url": "https://www.uniprot.org/uniprotkb/P49662" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.7797510", "abstract": "", 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"glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases.", "journal": "The Journal of biological chemistry", "date": "1995", "authors": "Munday NA, Vaillancourt JP, Ali A, Casano FJ, Miller DK, Molineaux SM, Yamin TT, Yu VL, Nicholson DW", "reference": { "type": "PubMed", "id": "7797592", "url": "https://pubmed.ncbi.nlm.nih.gov/7797592" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P49662-1", "protein_name": "Caspase-4", "gene_name": "CASP4", "tax_name": "Human" }, { "uniprot_canonical_ac": "P51878-1", "protein_name": "Caspase-5", "gene_name": "CASP5", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P49662", "url": "https://www.uniprot.org/uniprotkb/P49662" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.7797592", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", 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], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Mutating the four extracellular cysteines in the chemokine receptor CCR6 reveals their differing roles in receptor trafficking, ligand binding, and signaling.", "journal": "Biochemistry", "date": "2002", "authors": "Ai LS, Liao F", "reference": { "type": "PubMed", "id": "12081481", "url": "https://pubmed.ncbi.nlm.nih.gov/12081481" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P51684-1", "protein_name": "C-C chemokine receptor type 6", "gene_name": "CCR6", "tax_name": 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Loss of calcium flux in response to CCL20 stimulation and significant reduction in cell surface expression; when associated with S-36; S-197 and S-288.", "evidence": [ { "database": "UniProtKB", "id": "P51684", "url": "https://www.uniprot.org/uniprotkb/P51684" }, { "database": "PubMed", "id": "12081481", "url": "https://pubmed.ncbi.nlm.nih.gov/12081481" } ], "uniprot_canonical_ac": "P51684-1" }, { "start_pos": 131, "end_pos": 131, "sequence_org": "C", "sequence_mut": "S", "comment": "No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression.", "evidence": [ { "database": "UniProtKB", "id": "P51684", "url": "https://www.uniprot.org/uniprotkb/P51684" }, { "database": "PubMed", "id": "12081481", "url": "https://pubmed.ncbi.nlm.nih.gov/12081481" } ], "uniprot_canonical_ac": "P51684-1" }, { "start_pos": 138, "end_pos": 138, "sequence_org": "C", "sequence_mut": "S", "comment": "No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression.", "evidence": [ { "database": "UniProtKB", "id": "P51684", "url": "https://www.uniprot.org/uniprotkb/P51684" }, { "database": "PubMed", "id": "12081481", "url": "https://pubmed.ncbi.nlm.nih.gov/12081481" } ], "uniprot_canonical_ac": "P51684-1" }, { "start_pos": 168, "end_pos": 168, "sequence_org": "C", "sequence_mut": "S", "comment": "No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression.", "evidence": [ { "database": "UniProtKB", "id": "P51684", "url": "https://www.uniprot.org/uniprotkb/P51684" }, { "database": "PubMed", "id": "12081481", "url": "https://pubmed.ncbi.nlm.nih.gov/12081481" } ], "uniprot_canonical_ac": "P51684-1" }, { "start_pos": 197, "end_pos": 197, "sequence_org": "C", "sequence_mut": "S", "comment": "Loss of calcium flux and chemotaxis in response to CCL20 stimulation, impaired CCL20-binding and significant reduction in cell surface expression; when associated with or without S-118. Loss of calcium flux in response to CCL20 stimulation and significant reduction in cell surface expression; when associated with S-36; S-118 and S-288.", "evidence": [ { "database": "UniProtKB", "id": "P51684", "url": "https://www.uniprot.org/uniprotkb/P51684" }, { "database": "PubMed", "id": "12081481", "url": "https://pubmed.ncbi.nlm.nih.gov/12081481" } ], "uniprot_canonical_ac": "P51684-1" }, { "start_pos": 233, "end_pos": 233, "sequence_org": "C", "sequence_mut": "S", "comment": "No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression.", "evidence": [ { "database": "UniProtKB", "id": "P51684", "url": "https://www.uniprot.org/uniprotkb/P51684" }, { "database": "PubMed", "id": "12081481", "url": "https://pubmed.ncbi.nlm.nih.gov/12081481" } ], "uniprot_canonical_ac": "P51684-1" }, { "start_pos": 266, "end_pos": 266, "sequence_org": "C", "sequence_mut": "S", "comment": "No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression.", "evidence": [ { "database": "UniProtKB", "id": "P51684", "url": "https://www.uniprot.org/uniprotkb/P51684" }, { "database": "PubMed", "id": "12081481", "url": "https://pubmed.ncbi.nlm.nih.gov/12081481" } ], "uniprot_canonical_ac": "P51684-1" }, { "start_pos": 288, "end_pos": 288, "sequence_org": "C", "sequence_mut": "A", "comment": "No loss of calcium flux but loss of chemotaxis in response to CCL20 stimulation. No effect on cell surface expression.", "evidence": [ { "database": "UniProtKB", "id": "P51684", "url": "https://www.uniprot.org/uniprotkb/P51684" }, { "database": "PubMed", "id": "12081481", "url": "https://pubmed.ncbi.nlm.nih.gov/12081481" } ], "uniprot_canonical_ac": "P51684-1" }, { "start_pos": 288, "end_pos": 288, "sequence_org": "C", "sequence_mut": "G", "comment": "No loss of calcium flux but loss of chemotaxis in response to CCL20 stimulation. No effect on cell surface expression.", "evidence": [ { "database": "UniProtKB", "id": "P51684", "url": "https://www.uniprot.org/uniprotkb/P51684" }, { "database": "PubMed", "id": "12081481", "url": "https://pubmed.ncbi.nlm.nih.gov/12081481" } ], "uniprot_canonical_ac": "P51684-1" }, { "start_pos": 288, "end_pos": 288, "sequence_org": "C", "sequence_mut": "R", "comment": "No loss of calcium flux but loss of chemotaxis in response to CCL20 stimulation. No effect on cell surface expression.", "evidence": [ { "database": "UniProtKB", "id": "P51684", "url": "https://www.uniprot.org/uniprotkb/P51684" }, { "database": "PubMed", "id": "12081481", "url": "https://pubmed.ncbi.nlm.nih.gov/12081481" } ], "uniprot_canonical_ac": "P51684-1" }, { "start_pos": 288, "end_pos": 288, "sequence_org": "C", "sequence_mut": "S", "comment": "No loss of calcium flux but loss of chemotaxis in response to CCL20 stimulation, impaired CCL20-binding and no effect on cell surface expression; when associated with or without S-36. Loss of calcium flux in response to CCL20 stimulation and significant reduction in cell surface expression; when associated with S-36; S-118 and S-197.", "evidence": [ { "database": "UniProtKB", "id": "P51684", "url": "https://www.uniprot.org/uniprotkb/P51684" }, { "database": "PubMed", "id": "12081481", "url": "https://pubmed.ncbi.nlm.nih.gov/12081481" } ], "uniprot_canonical_ac": "P51684-1" }, { "start_pos": 309, "end_pos": 309, "sequence_org": "C", "sequence_mut": "S", "comment": "No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression.", "evidence": [ { "database": "UniProtKB", "id": "P51684", "url": "https://www.uniprot.org/uniprotkb/P51684" }, { "database": "PubMed", "id": "12081481", "url": "https://pubmed.ncbi.nlm.nih.gov/12081481" } ], "uniprot_canonical_ac": "P51684-1" }, { "start_pos": 310, "end_pos": 310, "sequence_org": "C", "sequence_mut": "S", "comment": "No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression.", "evidence": [ { "database": "UniProtKB", "id": "P51684", "url": "https://www.uniprot.org/uniprotkb/P51684" }, { "database": "PubMed", "id": "12081481", "url": "https://pubmed.ncbi.nlm.nih.gov/12081481" } ], "uniprot_canonical_ac": "P51684-1" }, { "start_pos": 336, "end_pos": 336, "sequence_org": "C", "sequence_mut": "S", "comment": "Reduced calcium flux and chemotaxis in response to CCL20 stimulation, and reduced CCL20-binding. No effect on cell surface expression.", "evidence": [ { "database": "UniProtKB", "id": "P51684", "url": "https://www.uniprot.org/uniprotkb/P51684" }, { "database": "PubMed", "id": "12081481", "url": "https://pubmed.ncbi.nlm.nih.gov/12081481" } ], "uniprot_canonical_ac": "P51684-1" }, { "start_pos": 348, "end_pos": 348, "sequence_org": "C", "sequence_mut": "S", "comment": "No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on CCL20-binding and cell surface expression.", "evidence": [ { "database": "UniProtKB", "id": "P51684", "url": "https://www.uniprot.org/uniprotkb/P51684" }, { "database": "PubMed", "id": "12081481", "url": "https://pubmed.ncbi.nlm.nih.gov/12081481" } ], "uniprot_canonical_ac": "P51684-1" }, { "start_pos": 36, "end_pos": 36, "sequence_org": "C", "sequence_mut": "A", "comment": "No loss of calcium flux but loss of chemotaxis in response to CCL20 stimulation. No effect on cell surface expression.", "evidence": [ { "database": "UniProtKB", "id": "P51684", "url": "https://www.uniprot.org/uniprotkb/P51684" }, { "database": "PubMed", "id": "12081481", "url": "https://pubmed.ncbi.nlm.nih.gov/12081481" } ], "uniprot_canonical_ac": "P51684-1" }, { "start_pos": 36, "end_pos": 36, "sequence_org": "C", "sequence_mut": "D", "comment": "Loss of calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression.", "evidence": [ { "database": "UniProtKB", "id": "P51684", "url": "https://www.uniprot.org/uniprotkb/P51684" }, { "database": "PubMed", "id": "12081481", "url": "https://pubmed.ncbi.nlm.nih.gov/12081481" } ], "uniprot_canonical_ac": "P51684-1" }, { "start_pos": 36, "end_pos": 36, "sequence_org": "C", "sequence_mut": "G", "comment": "Loss of calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression.", "evidence": [ { "database": "UniProtKB", "id": "P51684", "url": "https://www.uniprot.org/uniprotkb/P51684" }, { "database": "PubMed", "id": "12081481", "url": "https://pubmed.ncbi.nlm.nih.gov/12081481" } ], "uniprot_canonical_ac": "P51684-1" }, { "start_pos": 36, "end_pos": 36, "sequence_org": "C", "sequence_mut": "S", "comment": "No loss of calcium flux but loss of chemotaxis in response to CCL20 stimulation, impaired CCL20-binding and no effect on cell surface expression; when associated with or without S-288. Loss of calcium flux in response to CCL20 stimulation and significant reduction in cell surface expression; when associated with S-118; S-197 and S-288.", "evidence": [ { "database": "UniProtKB", "id": "P51684", "url": "https://www.uniprot.org/uniprotkb/P51684" }, { "database": "PubMed", "id": "12081481", "url": "https://pubmed.ncbi.nlm.nih.gov/12081481" } ], "uniprot_canonical_ac": "P51684-1" }, { "start_pos": 57, "end_pos": 57, "sequence_org": "C", "sequence_mut": "S", "comment": "No effect on calcium flux and chemotaxis in response to CCL20 stimulation. 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "CCL18 aggravates atherosclerosis by inducing CCR6-dependent T-cell influx and polarization.", "journal": "Frontiers in immunology", "date": "2024", "authors": "Singh Anjana, Kraaijeveld Adriaan O, Curaj Adelina, Wichapong Kanin, Hammerich Linda, de Jager Saskia C A, Bot Ilze, Atamas Sergei P, van Berkel Theo J C, Jukema J Wouter, Comerford Iain, McColl Shaun R, Mees Barend, Heemskerk Johan W M, Nicolaes Gerry A F, Hackeng Tilman, Liehn Elisa Anamaria, Tacke Frank, Biessen Erik A L", "reference": { "type": "PubMed", "id": "38807599", "url": "https://pubmed.ncbi.nlm.nih.gov/38807599" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P51684-1", "protein_name": "C-C chemokine receptor type 6", "gene_name": "CCR6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55774-1", "protein_name": "C-C motif chemokine 18", "gene_name": "CCL18", "tax_name": "Human" } ], 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Biophys. Res. Commun.", "date": "1996", "authors": "Zaballos A, Varona R, Guti\u00e9rrez J, Lind P, M\u00e1rquez G", "reference": { "type": "PubMed", "id": "8886020", "url": "https://pubmed.ncbi.nlm.nih.gov/8886020" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P51684-1", "protein_name": "C-C chemokine receptor type 6", "gene_name": "CCR6", "tax_name": "Human" }, { "uniprot_canonical_ac": "P51685-1", "protein_name": "C-C chemokine receptor type 8", "gene_name": "CCR8", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P51684", "url": "https://www.uniprot.org/uniprotkb/P51684" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.8886020", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { 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Gaffar KA, Awawdeh L, Briggs J, Yaghmai R, Jabs EW, Hoeger P, Bleck O, Rudiger SG, Petersilka G, Battino M, Brett P, Hattab F, Al-Hamed M, Sloan P, Toomes C, Dixon M, James J, Read AP, Thakker N", "reference": { "type": "PubMed", "id": "14974080", "url": "https://pubmed.ncbi.nlm.nih.gov/14974080" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P53634-1", "protein_name": "Dipeptidyl peptidase 1", "gene_name": "CTSC", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P53634", "url": "https://www.uniprot.org/uniprotkb/P53634" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.14974080", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], 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Mol. Genet.", "date": "2015", "authors": "Mencacci Niccolo E, R'bibo L\u00e9a, Bandres-Ciga Sara, Carecchio Miryam, Zorzi Giovanna, Nardocci Nardo, Garavaglia Barbara, Batla Amit, Bhatia Kailash P, Pittman Alan M, Hardy John, Weissbach Anne, Klein Christine, Gasser Thomas, Lohmann Ebba, Wood Nicholas W", "reference": { "type": "PubMed", "id": "26157024", "url": "https://pubmed.ncbi.nlm.nih.gov/26157024" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q00975-1", "protein_name": "Voltage-dependent N-type calcium channel subunit alpha-1B", "gene_name": "CACNA1B", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00975", "url": "https://www.uniprot.org/uniprotkb/Q00975" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.26157024", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": 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Sieciechowicz D, Jan-Kamsteeg E, Paciorkowski AR, King MD, Cross JH, Poduri A, Mefford HC, Scheffer IE, Haack TB, McCullagh G, Millichap JJ, Carvill GL, Clayton-Smith J, Maher ER, Raymond FL, Kurian MA", "reference": { "type": "PubMed", "id": "30982612", "url": "https://pubmed.ncbi.nlm.nih.gov/30982612" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q00975-1", "protein_name": "Voltage-dependent N-type calcium channel subunit alpha-1B", "gene_name": "CACNA1B", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q00975", "url": "https://www.uniprot.org/uniprotkb/Q00975" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.30982612", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { 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