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"journal": "The American journal of surgical pathology", "date": "2022-10-12", "authors": "Weinreb Ilan, Hahn Elan, Dickson Brendan C, Rooper Lisa M, Rupp Niels J, Freiberger Sandra N, Lubin Daniel, Gagan Jeffrey, Bishop Justin A", "reference": { "type": "PubMed", "id": "36221318", "url": "https://pubmed.ncbi.nlm.nih.gov/36221318" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q15532-1", "protein_name": "Protein SSXT", "gene_name": "SS18", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q15532", "url": "https://www.uniprot.org/uniprotkb/Q15532" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.36221318", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", 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Genet.", "date": "1994", "authors": "Clark J, Rocques PJ, Crew AJ, Gill S, Shipley J, Chan AM, Gusterson BA, Cooper CS", "reference": { "type": "PubMed", "id": "7951320", "url": "https://pubmed.ncbi.nlm.nih.gov/7951320" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q15532-1", "protein_name": "Protein SSXT", "gene_name": "SS18", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q16385-1", "protein_name": "Protein SSX2", "gene_name": "SSX2B; SSX2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q15532", "url": "https://www.uniprot.org/uniprotkb/Q15532" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.7951320", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Glucose-induced autophagy of peroxisomes in Pichia pastoris requires a unique E1-like protein.", "journal": "Mol. 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Cell", "date": "1999", "authors": "Yuan W, Stromhaug PE, Dunn WA Jr", "reference": { "type": "PubMed", "id": "10233149", "url": "https://pubmed.ncbi.nlm.nih.gov/10233149" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95352-1", "protein_name": "Ubiquitin-like modifier-activating enzyme ATG7", "gene_name": "ATG7", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95352", "url": "https://www.uniprot.org/uniprotkb/O95352" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10233149", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": 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Chem.", "date": "2013", "authors": "Desai Shruti, Liu Zixing, Yao Jun, Patel Nishant, Chen Jieqing, Wu Yun, Ahn Erin Eun-Young, Fodstad Oystein, Tan Ming", "reference": { "type": "PubMed", "id": "23386620", "url": "https://pubmed.ncbi.nlm.nih.gov/23386620" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95352-1", "protein_name": "Ubiquitin-like modifier-activating enzyme ATG7", "gene_name": "ATG7", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95352", "url": "https://www.uniprot.org/uniprotkb/O95352" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.23386620", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Identification and characterization of the linear region of ATG3 that interacts with ATG7 in higher eukaryotes.", "journal": "Biochemical and biophysical research communications", "date": "2015-07-31", "authors": "Ohashi Kazuto, Otomo Takanori", "reference": { "type": "PubMed", "id": "26043688", "url": "https://pubmed.ncbi.nlm.nih.gov/26043688" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95352-1", "protein_name": "Ubiquitin-like modifier-activating enzyme ATG7", "gene_name": "ATG7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9NT62-1", "protein_name": "Ubiquitin-like-conjugating enzyme ATG3", "gene_name": "ATG3", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95352", "url": "https://www.uniprot.org/uniprotkb/O95352" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 243, "end_pos": 243, "sequence_org": "W", "sequence_mut": "A", "comment": "Moderately impairs ATG3 binding. Moderately reduces GABARAP-ATG3 thioester bond formation. Moderately reduces GABARAP lipidation.", "evidence": [ { "database": "UniProtKB", "id": "O95352", "url": "https://www.uniprot.org/uniprotkb/O95352" }, { "database": "PubMed", "id": "26043688", "url": "https://pubmed.ncbi.nlm.nih.gov/26043688" } ], "uniprot_canonical_ac": "O95352-1" }, { "start_pos": 246, "end_pos": 246, "sequence_org": "R", "sequence_mut": "D", "comment": "Almost completely impairs ATG3 binding. Severely reduces GABARAP-ATG3 thioester bond formation. Severely reduces GABARAP lipidation.", "evidence": [ { "database": "UniProtKB", "id": "O95352", "url": "https://www.uniprot.org/uniprotkb/O95352" }, { "database": "PubMed", "id": "26043688", "url": "https://pubmed.ncbi.nlm.nih.gov/26043688" } ], "uniprot_canonical_ac": "O95352-1" }, { "start_pos": 156, "end_pos": 156, "sequence_org": "D", "sequence_mut": "A", "comment": "Strongly decreases affinity for the complex ATG12:ATG5:ATG16L1. Impairs interaction with the complex ATG12:ATG5:ATG16L1; when associated with A-157. Impairs phosphatidylethanolamine (PE)-conjugated ATG8-like protein formation. Loss of phosphatidylethanolamine (PE)-conjugated ATG8-like proteins formation; when associated with A-157. Impairs interaction with ATG12:ATG5; when associated with A-157. Does not affect interaction with ATG7; when associated with A-157. Does not affect the formation of the ATG8-like protein:ATG3 intermediate complex; when associated with A-157. Affects modestly the ATG3-ATG7 interaction; when associated with A-157. Reduces the thioester-linkage formation with GABARAP; when associated with A-157.", "evidence": [ { "database": "UniProtKB", "id": "Q9NT62", "url": "https://www.uniprot.org/uniprotkb/Q9NT62" }, { "database": "PubMed", "id": "26043688", "url": "https://pubmed.ncbi.nlm.nih.gov/26043688" }, { "database": "PubMed", "id": "24191030", "url": "https://pubmed.ncbi.nlm.nih.gov/24191030" } ], "uniprot_canonical_ac": "Q9NT62-1" }, { "start_pos": 157, "end_pos": 157, "sequence_org": "M", "sequence_mut": "A", "comment": "Strongly decreases affinity for the complex ATG12:ATG5:ATG16L1. Impairs interaction with the complex ATG12:ATG5:ATG16L1; when associated with A-156. Impairs phosphatidylethanolamine (PE)-conjugated ATG8-like proteins formation. Loss of phosphatidylethanolamine (PE)-conjugated ATG8-like proteins formation; when associated with A-156. Impairs interaction with ATG12:ATG5; when associated with A-156. Does not affect interaction with ATG7; when associated with A-156. Does not affect the formation of the ATG8-like protein:ATG3 intermediate complex; when associated with A-156. Affects modestly the ATG3-ATG7 interaction; when associated with A-156. Reduces the thioester-linkage formation with GABARAP; when associated with A-156.", "evidence": [ { "database": "UniProtKB", "id": "Q9NT62", "url": "https://www.uniprot.org/uniprotkb/Q9NT62" }, { "database": "PubMed", "id": "26043688", "url": "https://pubmed.ncbi.nlm.nih.gov/26043688" }, { "database": "PubMed", "id": "24191030", "url": "https://pubmed.ncbi.nlm.nih.gov/24191030" } ], "uniprot_canonical_ac": "Q9NT62-1" }, { "start_pos": 160, "end_pos": 160, "sequence_org": "Y", "sequence_mut": "A", "comment": "Strongly decreases affinity for the complex ATG12:ATG5:ATG16L1. Affects modestly the ATG3-ATG7 interaction. Reduces the thioester-linkage formation with GABARAP.", "evidence": [ { "database": "UniProtKB", "id": "Q9NT62", "url": "https://www.uniprot.org/uniprotkb/Q9NT62" }, { "database": "PubMed", "id": "26043688", "url": "https://pubmed.ncbi.nlm.nih.gov/26043688" }, { "database": "PubMed", "id": "24191030", "url": "https://pubmed.ncbi.nlm.nih.gov/24191030" } ], "uniprot_canonical_ac": "Q9NT62-1" }, { "start_pos": 167, "end_pos": 167, "sequence_org": "E", "sequence_mut": "A", "comment": "Weakens the ATG3-ATG7 interaction. Reduces the thioester-linkage formation with GABARAP.", "evidence": [ { "database": "UniProtKB", "id": "Q9NT62", "url": "https://www.uniprot.org/uniprotkb/Q9NT62" }, { "database": "PubMed", "id": "26043688", "url": "https://pubmed.ncbi.nlm.nih.gov/26043688" } ], "uniprot_canonical_ac": "Q9NT62-1" }, { "start_pos": 169, "end_pos": 169, "sequence_org": "D", "sequence_mut": "A", "comment": "Weakens the ATG3-ATG7 interaction. Severely reduces the thioester-linkage formation with GABARAP.", "evidence": [ { "database": "UniProtKB", "id": "Q9NT62", "url": "https://www.uniprot.org/uniprotkb/Q9NT62" }, { "database": "PubMed", "id": "26043688", "url": "https://pubmed.ncbi.nlm.nih.gov/26043688" } ], "uniprot_canonical_ac": "Q9NT62-1" }, { "start_pos": 171, "end_pos": 171, "sequence_org": "A", "sequence_mut": "A", "comment": "Weakens the ATG3-ATG7 interaction. Reduces the thioester-linkage formation with GABARAP.", "evidence": [ { "database": "UniProtKB", "id": "Q9NT62", "url": "https://www.uniprot.org/uniprotkb/Q9NT62" }, { "database": "PubMed", "id": "26043688", "url": "https://pubmed.ncbi.nlm.nih.gov/26043688" } ], "uniprot_canonical_ac": "Q9NT62-1" }, { "start_pos": 172, "end_pos": 172, "sequence_org": "T", "sequence_mut": "A", "comment": "Weakens the ATG3-ATG7 interaction. Significantly reduces the thioester-linkage formation with GABARAP.", "evidence": [ { "database": "UniProtKB", "id": "Q9NT62", "url": "https://www.uniprot.org/uniprotkb/Q9NT62" }, { "database": "PubMed", "id": "26043688", "url": "https://pubmed.ncbi.nlm.nih.gov/26043688" } ], "uniprot_canonical_ac": "Q9NT62-1" }, { "start_pos": 173, "end_pos": 173, "sequence_org": "L", "sequence_mut": "A", "comment": "Weakens the ATG3-ATG7 interaction. Significantly reduces the thioester-linkage formation with GABARAP.", "evidence": [ { "database": "UniProtKB", "id": "Q9NT62", "url": "https://www.uniprot.org/uniprotkb/Q9NT62" }, { "database": "PubMed", "id": "26043688", "url": "https://pubmed.ncbi.nlm.nih.gov/26043688" } ], "uniprot_canonical_ac": "Q9NT62-1" } ], "record_id": "pubmed.26043688", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, 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"n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Developmental Consequences of Defective ATG7-Mediated Autophagy in Humans.", "journal": "The New England journal of medicine", "date": "2021", "authors": "Collier JJ, Guissart C, Olahova M, Sasorith S, Piron-Prunier F, Suomi F, Zhang D, Martinez-Lopez N, Leboucq N, Bahr A, Azzarello-Burri S, Reich S, Schols L, Polvikoski TM, Meyer P, Larrieu L, Schaefer AM, Alsaif HS, Alyamani S, Zuchner S, Barbosa IA, Deshpande C, Pyle A, Rauch A, Synofzik M, Alkuraya FS, Rivier F, Ryten M, McFarland R, Delahodde A, McWilliams TG, Koenig M, Taylor RW", "reference": { "type": "PubMed", "id": "34161705", "url": "https://pubmed.ncbi.nlm.nih.gov/34161705" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95352-1", "protein_name": "Ubiquitin-like modifier-activating enzyme ATG7", "gene_name": "ATG7", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95352", "url": "https://www.uniprot.org/uniprotkb/O95352" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 572, "end_pos": 572, "sequence_org": "C", "sequence_mut": "A", "comment": "Loss of LC3-I lipidation to form LC3-II.", "evidence": [ { "database": "UniProtKB", "id": "O95352", "url": "https://www.uniprot.org/uniprotkb/O95352" }, { "database": "PubMed", "id": "34161705", "url": "https://pubmed.ncbi.nlm.nih.gov/34161705" } ], "uniprot_canonical_ac": "O95352-1" } ], "record_id": "pubmed.34161705", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "ATM-CHK2-TRIM32 axis regulates ATG7 ubiquitination to initiate autophagy under oxidative stress.", "journal": "Cell reports", "date": "2023-11-28", "authors": "Liu Jingwei, Lu Songming, Zheng Lixia, Guo Qiqiang, Cao Liangzi, Xiao Yutong, Chen Di, Zou Yu, Liu Xu, Deng Chengsi, Zhang Siyi, Yang Ruohan, Wang Yubang, Zhang Ying, Zhang Naijin, Song Xiaoyu, Xing Chengzhong, Wang Zhenning, Cao Liu", "reference": { "type": "PubMed", "id": "37943659", "url": "https://pubmed.ncbi.nlm.nih.gov/37943659" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O95352-1", "protein_name": "Ubiquitin-like modifier-activating enzyme ATG7", "gene_name": "ATG7", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q13049-1", "protein_name": "E3 ubiquitin-protein ligase TRIM32", "gene_name": "TRIM32", "tax_name": "Human" }, { "uniprot_canonical_ac": "O96017-1", "protein_name": "Serine/threonine-protein kinase Chk2", "gene_name": "CHEK2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O95352", "url": "https://www.uniprot.org/uniprotkb/O95352" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 45, "end_pos": 45, "sequence_org": "K", "sequence_mut": "R", "comment": "Impairs interaction with ATG12. Impairs inrteraction with MAP1LC3B.", "evidence": [ { "database": "UniProtKB", "id": "O95352", "url": "https://www.uniprot.org/uniprotkb/O95352" }, { "database": "PubMed", "id": "37943659", "url": "https://pubmed.ncbi.nlm.nih.gov/37943659" } ], "uniprot_canonical_ac": "O95352-1" }, { "start_pos": 39, "end_pos": 39, "sequence_org": "C", "sequence_mut": "S", "comment": "Abolished E3 ubiquitin ligase activity and ability to activate ULK1. 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