[
    {
        "title": "SUMOylation modulates the function of Aurora-B kinase.",
        "journal": "Journal of cell science",
        "date": "2010",
        "authors": "Fernandez-Miranda G, Perez de Castro I, Carmena M, Aguirre-Portoles C, Ruchaud S, Fant X, Montoya G, Earnshaw WC, Malumbres M",
        "reference": {
            "type": "PubMed",
            "id": "20663916",
            "url": "https://pubmed.ncbi.nlm.nih.gov/20663916"
        },
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                "name": "Homo sapiens",
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        "abstract": "",
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    {
        "title": "Sumoylation of ING2 regulates the transcription mediated by Sin3A.",
        "journal": "Oncogene",
        "date": "2010",
        "authors": "Ythier D, Larrieu D, Binet R, Binda O, Brambilla C, Gazzeri S, Pedeux R",
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        "title": "A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells.",
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        "title": "Crystal structure of SUMO-modified proliferating cell nuclear antigen.",
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        "authors": "Freudenthal BD, Brogie JE, Gakhar L, Kondratick CM, Washington MT",
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        "title": "SUMO-1 regulates the conformational dynamics of thymine-DNA Glycosylase regulatory domain and competes with its DNA binding activity.",
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    {
        "title": "The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability.",
        "journal": "FEBS letters",
        "date": "2011",
        "authors": "Stephan AK, Kliszczak M, Morrison CG",
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        "title": "SUMOylation of the Forkhead transcription factor FOXL2 promotes its stabilization/activation through transient recruitment to PML bodies.",
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        "date": "2011",
        "authors": "Georges A, Benayoun BA, Marongiu M, Dipietromaria A, L'Hote D, Todeschini AL, Auer J, Crisponi L, Veitia RA",
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    {
        "title": "Small ubiquitin-like modifier (SUMO) modification of zinc finger protein 131 potentiates its negative effect on estrogen signaling.",
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        "date": "2012",
        "authors": "Oh Y, Chung KC",
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    {
        "title": "Dynamically regulated sumoylation of HDAC2 controls p53 deacetylation and restricts apoptosis following genotoxic stress.",
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        "date": "2012",
        "authors": "Brandl A, Wagner T, Uhlig KM, Knauer SK, Stauber RH, Melchior F, Schneider G, Heinzel T, Kramer OH",
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    {
        "title": "DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger.",
        "journal": "The Journal of cell biology",
        "date": "2012",
        "authors": "Danielsen JR, Povlsen LK, Villumsen BH, Streicher W, Nilsson J, Wikstrom M, Bekker-Jensen S, Mailand N",
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    {
        "title": "Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl.",
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    {
        "title": "Targeted identification of SUMOylation sites in human proteins using affinity enrichment and paralog-specific reporter ions.",
        "journal": "Molecular &amp; cellular proteomics : MCP",
        "date": "2013",
        "authors": "Lamoliatte F, Bonneil E, Durette C, Caron-Lizotte O, Wildemann D, Zerweck J, Wenshuk H, Thibault P",
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        "record_id": "pubmed.23750026",
        "abstract": "",
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        "title": "DNA-dependent SUMO modification of PARP-1.",
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    {
        "title": "BLM SUMOylation regulates ssDNA accumulation at stalled replication forks.",
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        "authors": "Ouyang KJ, Yagle MK, Matunis MJ, Ellis NA",
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        "title": "A role for paralog-specific sumoylation in histone deacetylase 1 stability.",
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                "table_id": "glycosylation_automatic_literature_mining",
                "table_stats": [
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                        "count": 0
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        ]
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    {
        "title": "Proteome-wide identification of SUMO2 modification sites.",
        "journal": "Science signaling",
        "date": "2014",
        "authors": "Tammsalu T, Matic I, Jaffray EG, Ibrahim AFM, Tatham MH, Hay RT",
        "reference": {
            "type": "PubMed",
            "id": "24782567",
            "url": "https://pubmed.ncbi.nlm.nih.gov/24782567"
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            {
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        ],
        "species": [
            {
                "name": "Homo sapiens",
                "taxid": 9606,
                "evidence": [
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                        "database": "UniProtKB",
                        "id": "P55854",
                        "url": "https://www.uniprot.org/uniprotkb/P55854"
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                ],
                "common_name": "Human",
                "glygen_name": "Human",
                "reference_species": "Homo sapiens [9606]"
            }
        ],
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    {
        "title": "Sumoylation of HDAC2 promotes NF-kappaB-dependent gene expression.",
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        "date": "2015",
        "authors": "Wagner T, Kiweler N, Wolff K, Knauer SK, Brandl A, Hemmerich P, Dannenberg JH, Heinzel T, Schneider G, Kramer OH",
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        "title": "SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair.",
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        "title": "HIC1 (hypermethylated in cancer 1) SUMOylation is dispensable for DNA repair but is essential for the apoptotic DNA damage response (DDR) to irreparable DNA double-strand breaks (DSBs).",
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        "title": "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH.",
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    {
        "title": "Covalent modification of PML by the sentrin family of ubiquitin-like proteins.",
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        "authors": "Kamitani T, Nguyen HP, Kito K, Fukuda-Kamitani T, Yeh ET",
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                "uniprot_canonical_ac": "Q9UKX7-1",
                "protein_name": "Nuclear pore complex protein Nup50",
                "gene_name": "NUP50",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P57740-1",
                "protein_name": "Nuclear pore complex protein Nup107",
                "gene_name": "NUP107",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8NDX5-1",
                "protein_name": "Polyhomeotic-like protein 3",
                "gene_name": "PHC3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8WUM0-1",
                "protein_name": "Nuclear pore complex protein Nup133",
                "gene_name": "NUP133",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9BTX1-1",
                "protein_name": "Nucleoporin NDC1",
                "gene_name": "NDC1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8N3U4-1",
                "protein_name": "Cohesin subunit SA-2",
                "gene_name": "STAG2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8NFH3-1",
                "protein_name": "Nucleoporin Nup43",
                "gene_name": "NUP43",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8WVM7-1",
                "protein_name": "Cohesin subunit SA-1",
                "gene_name": "STAG1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8TEM1-1",
                "protein_name": "Nuclear pore membrane glycoprotein 210",
                "gene_name": "NUP210",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P55735-1",
                "protein_name": "Protein SEC13 homolog",
                "gene_name": "SEC13",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8IY18-1",
                "protein_name": "Structural maintenance of chromosomes protein 5",
                "gene_name": "SMC5",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q14683-1",
                "protein_name": "Structural maintenance of chromosomes protein 1A",
                "gene_name": "SMC1A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P42771-1",
                "protein_name": "Cyclin-dependent kinase inhibitor 2A",
                "gene_name": "CDKN2A",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q14676-1",
                "protein_name": "Mediator of DNA damage checkpoint protein 1",
                "gene_name": "MDC1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O75694-1",
                "protein_name": "Nuclear pore complex protein Nup155",
                "gene_name": "NUP155",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P27694-1",
                "protein_name": "Replication protein A 70 kDa DNA-binding subunit",
                "gene_name": "RPA1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P54132-1",
                "protein_name": "RecQ-like DNA helicase BLM",
                "gene_name": "BLM",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q14191-1",
                "protein_name": "Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN",
                "gene_name": "WRN",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q14781-1",
                "protein_name": "Chromobox protein homolog 2",
                "gene_name": "CBX2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P41208-1",
                "protein_name": "Centrin-2",
                "gene_name": "CETN2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q01831-1",
                "protein_name": "DNA repair protein complementing XP-C cells",
                "gene_name": "XPC",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q96MF7-1",
                "protein_name": "E3 SUMO-protein ligase NSE2",
                "gene_name": "NSMCE2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8WV22-1",
                "protein_name": "Non-structural maintenance of chromosomes element 1 homolog",
                "gene_name": "NSMCE1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8NFH5-1",
                "protein_name": "Nucleoporin NUP35",
                "gene_name": "NUP35",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q96HA1-1",
                "protein_name": "Nuclear envelope pore membrane protein POM 121",
                "gene_name": "POM121",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8WUI4-1",
                "protein_name": "Histone deacetylase 7",
                "gene_name": "HDAC7",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8IXK0-1",
                "protein_name": "Polyhomeotic-like protein 2",
                "gene_name": "PHC2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P63279-1",
                "protein_name": "SUMO-conjugating enzyme UBC9",
                "gene_name": "UBE2I",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q13426-1",
                "protein_name": "DNA repair protein XRCC4",
                "gene_name": "XRCC4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P23497-1",
                "protein_name": "Nuclear autoantigen Sp-100",
                "gene_name": "SP100",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P09874-1",
                "protein_name": "Poly [ADP-ribose] polymerase 1",
                "gene_name": "PARP1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P63165-1",
                "protein_name": "Small ubiquitin-related modifier 1",
                "gene_name": "SUMO1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P49790-1",
                "protein_name": "Nuclear pore complex protein Nup153",
                "gene_name": "NUP153",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q12769-1",
                "protein_name": "Nuclear pore complex protein Nup160",
                "gene_name": "NUP160",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O60216-1",
                "protein_name": "Double-strand-break repair protein rad21 homolog",
                "gene_name": "RAD21",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P49792-1",
                "protein_name": "E3 SUMO-protein ligase RanBP2",
                "gene_name": "RANBP2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O75925-1",
                "protein_name": "E3 SUMO-protein ligase PIAS1",
                "gene_name": "PIAS1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P61956-1",
                "protein_name": "Small ubiquitin-related modifier 2",
                "gene_name": "SUMO2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P35226-1",
                "protein_name": "Polycomb complex protein BMI-1",
                "gene_name": "BMI1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P78364-1",
                "protein_name": "Polyhomeotic-like protein 1",
                "gene_name": "PHC1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q99496-1",
                "protein_name": "E3 ubiquitin-protein ligase RING2",
                "gene_name": "RNF2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q06587-1",
                "protein_name": "E3 ubiquitin-protein ligase RING1",
                "gene_name": "RING1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8IYW5-1",
                "protein_name": "E3 ubiquitin-protein ligase RNF168",
                "gene_name": "RNF168",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q99567-1",
                "protein_name": "Nuclear pore complex protein Nup88",
                "gene_name": "NUP88",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P43351-1",
                "protein_name": "DNA repair protein RAD52 homolog",
                "gene_name": "RAD52",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8N2W9-1",
                "protein_name": "E3 SUMO-protein ligase PIAS4",
                "gene_name": "PIAS4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P78406-1",
                "protein_name": "mRNA export factor RAE1",
                "gene_name": "RAE1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8NFH4-1",
                "protein_name": "Nucleoporin Nup37",
                "gene_name": "NUP37",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8N1F7-1",
                "protein_name": "Nuclear pore complex protein Nup93",
                "gene_name": "NUP93",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P35227-1",
                "protein_name": "Polycomb group RING finger protein 2",
                "gene_name": "PCGF2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q7Z3B4-1",
                "protein_name": "Nucleoporin p54",
                "gene_name": "NUP54",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O95714-1",
                "protein_name": "E3 ubiquitin-protein ligase HERC2",
                "gene_name": "HERC2",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P12270-1",
                "protein_name": "Nucleoprotein TPR",
                "gene_name": "TPR",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9UQE7-1",
                "protein_name": "Structural maintenance of chromosomes protein 3",
                "gene_name": "SMC3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q96MG7-1",
                "protein_name": "Non-structural maintenance of chromosomes element 3 homolog",
                "gene_name": "NSMCE3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q8N140-1",
                "protein_name": "EP300-interacting inhibitor of differentiation 3",
                "gene_name": "EID3",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q9NRG9-1",
                "protein_name": "Aladin",
                "gene_name": "AAAS",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P38398-1",
                "protein_name": "Breast cancer type 1 susceptibility protein",
                "gene_name": "BRCA1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O00257-1",
                "protein_name": "E3 SUMO-protein ligase CBX4",
                "gene_name": "CBX4",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P37198-1",
                "protein_name": "Nuclear pore glycoprotein p62",
                "gene_name": "NUP62",
                "tax_name": "Human"
            }
        ],
        "species": [
            {
                "name": "Homo sapiens",
                "taxid": 9606,
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P55854",
                        "url": "https://www.uniprot.org/uniprotkb/P55854"
                    }
                ],
                "common_name": "Human",
                "glygen_name": "Human",
                "reference_species": "Homo sapiens [9606]"
            }
        ],
        "mutagenesis": [
            {
                "start_pos": 133,
                "end_pos": 133,
                "sequence_org": "K",
                "sequence_mut": "R",
                "comment": "Loss of 2 sumoylations; when associated with R-65 and R-490.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P29590",
                        "url": "https://www.uniprot.org/uniprotkb/P29590"
                    },
                    {
                        "database": "PubMed",
                        "id": "9756909",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/9756909"
                    }
                ],
                "uniprot_canonical_ac": "P29590-1"
            },
            {
                "start_pos": 150,
                "end_pos": 150,
                "sequence_org": "K",
                "sequence_mut": "R",
                "comment": "Loss of 2 sumoylations; when associated with R-65 and R-490.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P29590",
                        "url": "https://www.uniprot.org/uniprotkb/P29590"
                    },
                    {
                        "database": "PubMed",
                        "id": "9756909",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/9756909"
                    }
                ],
                "uniprot_canonical_ac": "P29590-1"
            },
            {
                "start_pos": 160,
                "end_pos": 160,
                "sequence_org": "K",
                "sequence_mut": "R",
                "comment": "Compromised the formation of high molecular weight species of SUMO1P1/SUMO5 conjugation on PML. Loss of 2 sumoylations; when associated with or without R-65. No sumoylation nor nuclear body formation; when associated with or without R-65 and R-490. Loss the ability to be conjugated by SUMO1P1/SUMO5 but could be conjugated by SUMO1; when associated with R-65 and R-490.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P29590",
                        "url": "https://www.uniprot.org/uniprotkb/P29590"
                    },
                    {
                        "database": "PubMed",
                        "id": "9756909",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/9756909"
                    },
                    {
                        "database": "PubMed",
                        "id": "27211601",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/27211601"
                    }
                ],
                "uniprot_canonical_ac": "P29590-1"
            },
            {
                "start_pos": 160,
                "end_pos": 160,
                "sequence_org": "K",
                "sequence_mut": "R",
                "comment": "Loss of 2 sumoylations; when associated with or without R-65. No sumoylation nor nuclear body formation; when associated with or without R-65 and R-490.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P29590",
                        "url": "https://www.uniprot.org/uniprotkb/P29590"
                    },
                    {
                        "database": "PubMed",
                        "id": "9756909",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/9756909"
                    }
                ],
                "uniprot_canonical_ac": "P29590-1"
            },
            {
                "start_pos": 490,
                "end_pos": 490,
                "sequence_org": "K",
                "sequence_mut": "A",
                "comment": "Loss of nuclear localization; when associated with A-487.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P29590",
                        "url": "https://www.uniprot.org/uniprotkb/P29590"
                    },
                    {
                        "database": "PubMed",
                        "id": "9756909",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/9756909"
                    },
                    {
                        "database": "PubMed",
                        "id": "18298799",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/18298799"
                    }
                ],
                "uniprot_canonical_ac": "P29590-1"
            },
            {
                "start_pos": 490,
                "end_pos": 490,
                "sequence_org": "K",
                "sequence_mut": "R",
                "comment": "Abolished conjugation of one SUMO1P1/SUMO5. Loss of 2 sumoylations; when associated with R-65 with or without R-133. No effect on nuclear body formation; when associated with R-65. No sumoylation nor nuclear body formation; when associated with R-65 and R-160. Loss the ability to be conjugated by SUMO1P1/SUMO5 but could be conjugated by SUMO1; when associated with R-65 and R-160.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P29590",
                        "url": "https://www.uniprot.org/uniprotkb/P29590"
                    },
                    {
                        "database": "PubMed",
                        "id": "27211601",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/27211601"
                    },
                    {
                        "database": "PubMed",
                        "id": "18298799",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/18298799"
                    },
                    {
                        "database": "PubMed",
                        "id": "9756909",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/9756909"
                    }
                ],
                "uniprot_canonical_ac": "P29590-1"
            },
            {
                "start_pos": 490,
                "end_pos": 490,
                "sequence_org": "K",
                "sequence_mut": "R",
                "comment": "Loss of 2 sumoylations; when associated with R-65 with or without R-133. No effect on nuclear body formation; when associated with R-65. No sumoylation nor nuclear body formation; when associated with R-65 and R-160.",
                "evidence": [
                    {
                        "database": "UniProtKB",
                        "id": "P29590",
                        "url": "https://www.uniprot.org/uniprotkb/P29590"
                    },
                    {
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                        "id": "18298799",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/18298799"
                    },
                    {
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                        "id": "9756909",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/9756909"
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                ],
                "uniprot_canonical_ac": "P29590-1"
            },
            {
                "start_pos": 65,
                "end_pos": 65,
                "sequence_org": "K",
                "sequence_mut": "R",
                "comment": "Loss of one sumoylation. No effect on nuclear body formation. Loss of 2 sumoylations; when associated with R-490 with or without R-133 or R-150. No effect on nuclear body formation; when associated with R-490. No sumoylation nor nuclear body formation; when associated with R-160 and R-490.",
                "evidence": [
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                        "id": "P29590",
                        "url": "https://www.uniprot.org/uniprotkb/P29590"
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                    {
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                        "id": "9756909",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/9756909"
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                        "id": "27211601",
                        "url": "https://pubmed.ncbi.nlm.nih.gov/27211601"
                    }
                ],
                "uniprot_canonical_ac": "P29590-1"
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        ],
        "record_id": "pubmed.9756909",
        "abstract": "",
        "glycosylation": [],
        "snv": [],
        "phosphorylation": [],
        "glycation": [],
        "section_stats": [
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