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Xist expression?", "journal": "Biochemical Society transactions", "date": "2024-06-26", "authors": "Wang Feng, Mehta Poonam, Bach Ingolf", "reference": { "type": "PubMed", "id": "38747697", "url": "https://pubmed.ncbi.nlm.nih.gov/38747697" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9NVW2-1", "protein_name": "E3 ubiquitin-protein ligase RLIM", "gene_name": "RLIM", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NVW2", "url": "https://www.uniprot.org/uniprotkb/Q9NVW2" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.38747697", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", 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Mac\u00e9 Pierre, Sigaudy Sabine, Glazunova Olga, Torrents Julia, Raymond Laure, Saint-Frison Marie-H\u00e9l\u00e8ne, Atti\u00e9-Bitach Tania, Lefebvre Mathilde, Capri Yline, Bourgon Nicolas, Thauvin-Robinet Christel, Tran Mau-Them Fr\u00e9d\u00e9ric, Bruel Ange-Line, Vitobello Antonio, Denomm\u00e9-Pichon Anne-Sophie, Faivre Laurence, Brehin Anne-Claire, Goldenberg Alice, Patrier-Sallebert Sophie, Perani Alexandre, Dauriat Benjamin, Bourthoumieu Sylvie, Yardin Catherine, Marquet Valentine, Barnique Marion, Fiorenza-Gasq Maryse, Marey Isabelle, Tournadre Danielle, Doumit Ra\u00efa, Nugues Fr\u00e9d\u00e9rique, Barakat Tahsin Stefan, Bustos Francisco, Jaillard Sylvie, Launay Erika, Pasquier Laurent, Odent Sylvie", "reference": { "type": "PubMed", "id": "38849204", "url": "https://pubmed.ncbi.nlm.nih.gov/38849204" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9NVW2-1", "protein_name": "E3 ubiquitin-protein ligase RLIM", "gene_name": "RLIM", "tax_name": 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S C, Hock Daniella H, Lake Nicole J, Calvo Sarah E, Gr\u00f8nborg Sabine W, Krzesinski Emma I, Amor David J, Fahey Michael C, Simons Cas, Wibrand Flemming, Mootha Vamsi K, Lek Monkol, Lunke Sebastian, Stark Zornitza, \u00d8stergaard Elsebet, Christodoulou John, Thorburn David R, Stroud David A, Compton Alison G", "reference": { "type": "PubMed", "id": "37133451", "url": "https://pubmed.ncbi.nlm.nih.gov/37133451" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q9NYK5-1", "protein_name": "Large ribosomal subunit protein mL39", "gene_name": "MRPL39", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q9NYK5", "url": "https://www.uniprot.org/uniprotkb/Q9NYK5" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.37133451", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], 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"count": 0 } ], "sort_fields": [] } ] }, { "title": "Novel mutation in SLC6A19 causing late-onset seizures in Hartnup disorder.", "journal": "Pediatric neurology", "date": "2010", "authors": "Cheon CK, Lee BH, Ko JM, Kim HJ, Yoo HW", "reference": { "type": "PubMed", "id": "20399395", "url": "https://pubmed.ncbi.nlm.nih.gov/20399395" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q695T7-1", "protein_name": "Sodium-dependent neutral amino acid transporter B(0)AT1", "gene_name": "SLC6A19", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q695T7", "url": "https://www.uniprot.org/uniprotkb/Q695T7" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.20399395", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": 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Rep.", "date": "2016", "authors": "Van Schil K, Karlstetter M, Aslanidis A, Dannhausen K, Azam M, Qamar R, Leroy BP, Depasse F, Langmann T, De Baere E", "reference": { "type": "PubMed", "id": "26887858", "url": "https://pubmed.ncbi.nlm.nih.gov/26887858" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q7Z3H4-1", "protein_name": "Sterile alpha motif domain-containing protein 7", "gene_name": "SAMD7", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q7Z3H4", "url": "https://www.uniprot.org/uniprotkb/Q7Z3H4" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.26887858", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ 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"journal": "Antimicrobial agents and chemotherapy", "date": "2005", "authors": "Wu JZ, Larson G, Walker H, Shim JH, Hong Z", "reference": { "type": "PubMed", "id": "15917509", "url": "https://pubmed.ncbi.nlm.nih.gov/15917509" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43868-1", "protein_name": "Sodium/nucleoside cotransporter 2", "gene_name": "SLC28A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99808-1", "protein_name": "Equilibrative nucleoside transporter 1", "gene_name": "SLC29A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15531-1", "protein_name": "Nucleoside diphosphate kinase A", "gene_name": "NME1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BZD2-1", "protein_name": "Equilibrative nucleoside transporter 3", "gene_name": "SLC29A3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY32-1", "protein_name": "Inosine triphosphate pyrophosphatase", "gene_name": "ITPA", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Recent advances in studies on biochemical and structural properties of equilibrative and concentrative nucleoside transporters.", "journal": "Acta biochimica Polonica", "date": "2005", "authors": "Podgorska M, Kocbuch K, Pawelczyk T", "reference": { "type": "PubMed", "id": "16265592", "url": "https://pubmed.ncbi.nlm.nih.gov/16265592" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43868-1", "protein_name": "Sodium/nucleoside cotransporter 2", "gene_name": "SLC28A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99808-1", "protein_name": "Equilibrative nucleoside transporter 1", "gene_name": "SLC29A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15531-1", "protein_name": "Nucleoside diphosphate kinase A", "gene_name": "NME1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BZD2-1", "protein_name": "Equilibrative nucleoside transporter 3", "gene_name": "SLC29A3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY32-1", "protein_name": "Inosine triphosphate pyrophosphatase", "gene_name": "ITPA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22392-1", "protein_name": "Nucleoside diphosphate kinase 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therapy.", "journal": "The Journal of infectious diseases", "date": "2010", "authors": "Reiberger T, Kosi L, Maresch J, Breitenecker F, Payer BA, Wrba F, Rieger A, Gangl A, Peck-Radosavljevic M", "reference": { "type": "PubMed", "id": "20486858", "url": "https://pubmed.ncbi.nlm.nih.gov/20486858" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43868-1", "protein_name": "Sodium/nucleoside cotransporter 2", "gene_name": "SLC28A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99808-1", "protein_name": "Equilibrative nucleoside transporter 1", "gene_name": "SLC29A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15531-1", "protein_name": "Nucleoside diphosphate kinase A", "gene_name": "NME1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BZD2-1", "protein_name": "Equilibrative nucleoside transporter 3", "gene_name": "SLC29A3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY32-1", "protein_name": "Inosine triphosphate 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"field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The metabolism of ribavirin in erythrocytes and nucleated cells.", "journal": "The International journal of biochemistry", "date": "1990", "authors": "Page T, Connor JD", "reference": { "type": "PubMed", "id": "2159925", "url": "https://pubmed.ncbi.nlm.nih.gov/2159925" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43868-1", "protein_name": "Sodium/nucleoside cotransporter 2", "gene_name": "SLC28A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99808-1", "protein_name": "Equilibrative nucleoside transporter 1", "gene_name": "SLC29A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15531-1", "protein_name": "Nucleoside diphosphate kinase A", "gene_name": "NME1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BZD2-1", "protein_name": "Equilibrative nucleoside transporter 3", "gene_name": "SLC29A3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY32-1", "protein_name": "Inosine triphosphate pyrophosphatase", "gene_name": "ITPA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22392-1", "protein_name": "Nucleoside diphosphate kinase B", "gene_name": "NME1-NME2; NME2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55263-1", "protein_name": "Adenosine kinase", "gene_name": "ADK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00491-1", "protein_name": "Purine nucleoside phosphorylase", "gene_name": "PNP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HAS3-1", "protein_name": "Solute carrier family 28 member 3", "gene_name": "SLC28A3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49902-1", "protein_name": "Cytosolic purine 5'-nucleotidase", "gene_name": "NT5C2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00813-1", "protein_name": "Adenosine deaminase", "gene_name": "ADA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43868", "url": "https://www.uniprot.org/uniprotkb/O43868" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.2159925", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 11 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Nucleobase transport by human equilibrative nucleoside transporter 1 (hENT1).", "journal": "The Journal of biological chemistry", "date": "2011-09-16", "authors": "Yao Sylvia Y M, Ng Amy M L, Cass Carol E, Baldwin Stephen A, Young James D", "reference": { "type": "PubMed", "id": "21795683", "url": "https://pubmed.ncbi.nlm.nih.gov/21795683" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43868-1", "protein_name": "Sodium/nucleoside cotransporter 2", "gene_name": "SLC28A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q14542-1", "protein_name": "Equilibrative nucleoside transporter 2", "gene_name": "SLC29A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99808-1", "protein_name": "Equilibrative nucleoside transporter 1", "gene_name": "SLC29A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00337-1", "protein_name": "Sodium/nucleoside cotransporter 1", "gene_name": "SLC28A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HAS3-1", "protein_name": "Solute carrier family 28 member 3", "gene_name": "SLC28A3", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43868", "url": "https://www.uniprot.org/uniprotkb/O43868" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "mutagenesis": [ { "start_pos": 193, "end_pos": 193, "sequence_org": "C", "sequence_mut": "S", "comment": "Loss of nucleobase transport; when associated with S-87; S-213; S-222; S-297; S-333; S-378; S-414; S-416 and S-439. No change in nucleobase transport; when associated with S-87; S-213; S-222; S-297; S-333; S-378; S-416 and S-439.", "evidence": [ { "database": "UniProtKB", "id": "Q99808", "url": "https://www.uniprot.org/uniprotkb/Q99808" }, { "database": "PubMed", "id": "21795683", "url": "https://pubmed.ncbi.nlm.nih.gov/21795683" } ], "uniprot_canonical_ac": "Q99808-1" }, { "start_pos": 213, "end_pos": 213, "sequence_org": "C", "sequence_mut": "S", "comment": "Loss of nucleobase transport; when associated with S-87; S-193; S-222; S-297; S-333; S-378; S-414; S-416 and S-439. No change in nucleobase transport; when associated with S-87; S-193; S-222; S-297; S-333; S-378; S-416 and S-439.", "evidence": [ { "database": "UniProtKB", "id": "Q99808", "url": "https://www.uniprot.org/uniprotkb/Q99808" }, { "database": "PubMed", "id": "21795683", "url": "https://pubmed.ncbi.nlm.nih.gov/21795683" } ], "uniprot_canonical_ac": "Q99808-1" }, { "start_pos": 222, "end_pos": 222, "sequence_org": "C", "sequence_mut": "S", "comment": "Loss of nucleobase transport; when associated with S-87; S-193; S-213; S-297; S-333; S-378; S-414; S-416 and S-439. No change in nucleobase transport; when associated with S-87; S-193; S-213; S-297; S-333; S-378; S-416 and S-439.", "evidence": [ { "database": "UniProtKB", "id": "Q99808", "url": "https://www.uniprot.org/uniprotkb/Q99808" }, { "database": "PubMed", "id": "21795683", "url": "https://pubmed.ncbi.nlm.nih.gov/21795683" } ], "uniprot_canonical_ac": "Q99808-1" }, { "start_pos": 297, "end_pos": 297, "sequence_org": "C", "sequence_mut": "S", "comment": "Loss of nucleobase transport; when associated with S-87; S-193; S-213; S-222; S-333; S-378; S-414; S-416 and S-439. No change in nucleobase transport; when associated with S-87; S-193; S-213; S-222; S-333; S-378; S-416 and S-439.", "evidence": [ { "database": "UniProtKB", "id": "Q99808", "url": "https://www.uniprot.org/uniprotkb/Q99808" }, { "database": "PubMed", "id": "21795683", "url": "https://pubmed.ncbi.nlm.nih.gov/21795683" } ], "uniprot_canonical_ac": "Q99808-1" }, { "start_pos": 333, "end_pos": 333, "sequence_org": "C", "sequence_mut": "S", "comment": "Loss of nucleobase transport; when associated with S-87; S-193; S-213; S-222; S-297; S-378; S-414; S-416 and S-439. No change in nucleobase transport; when associated with S-87; S-193; S-213; S-222; S-297; S-378; S-416 and S-439.", "evidence": [ { "database": "UniProtKB", "id": "Q99808", "url": "https://www.uniprot.org/uniprotkb/Q99808" }, { "database": "PubMed", "id": "21795683", "url": "https://pubmed.ncbi.nlm.nih.gov/21795683" } ], "uniprot_canonical_ac": "Q99808-1" }, { "start_pos": 378, "end_pos": 378, "sequence_org": "C", "sequence_mut": "S", "comment": "Loss of nucleobase transport; when associated with S-87; S-193; S-213; S-222; S-297; S-333; S-414; S-416 and S-439. No change in nucleobase transport; when associated with S-87; S-193; S-213; S-222; S-297; S-333; S-416 and S-439.", "evidence": [ { "database": "UniProtKB", "id": "Q99808", "url": "https://www.uniprot.org/uniprotkb/Q99808" }, { "database": "PubMed", "id": "21795683", "url": "https://pubmed.ncbi.nlm.nih.gov/21795683" } ], "uniprot_canonical_ac": "Q99808-1" }, { "start_pos": 414, "end_pos": 414, "sequence_org": "C", "sequence_mut": "S", "comment": "Loss of nucleobase transport; when associated with S-87; S-193; S-213; S-222; S-297; S-333; S-378; S-416 and S-439.", "evidence": [ { "database": "UniProtKB", "id": "Q99808", "url": "https://www.uniprot.org/uniprotkb/Q99808" }, { "database": "PubMed", "id": "21795683", "url": "https://pubmed.ncbi.nlm.nih.gov/21795683" } ], "uniprot_canonical_ac": "Q99808-1" }, { "start_pos": 416, "end_pos": 416, "sequence_org": "C", "sequence_mut": "S", "comment": "Loss of nucleobase transport; when associated with S-87; S-193; S-213; S-222; S-297; S-333; S-378; S-414 and S-439. No change in nucleobase transport; when associated with S-87; S-193; S-213; S-222; S-297; S-333; S-378 and S-439.", "evidence": [ { "database": "UniProtKB", "id": "Q99808", "url": "https://www.uniprot.org/uniprotkb/Q99808" }, { "database": "PubMed", "id": "21795683", "url": "https://pubmed.ncbi.nlm.nih.gov/21795683" } ], "uniprot_canonical_ac": "Q99808-1" }, { "start_pos": 439, "end_pos": 439, "sequence_org": "C", "sequence_mut": "S", "comment": "Loss of nucleobase transport; when associated with S-87; S-193; S-213; S-222; S-297; S-333; S-378; S-414 and S-416. No change in nucleobase transport; when associated with S-87; S-193; S-213; S-222; S-297; S-333; S-378 and S-416.", "evidence": [ { "database": "UniProtKB", "id": "Q99808", "url": "https://www.uniprot.org/uniprotkb/Q99808" }, { "database": "PubMed", "id": "21795683", "url": "https://pubmed.ncbi.nlm.nih.gov/21795683" } ], "uniprot_canonical_ac": "Q99808-1" }, { "start_pos": 87, "end_pos": 87, "sequence_org": "C", "sequence_mut": "S", "comment": "Loss of nucleobase transport; when associated with S-193; S-213; S-222; S-297; S-333; S-378; S-414; S-416 and S-439. No change in nucleobase transport; when associated with S-193; S-213; S-222; S-297; S-333; S-378; S-416 and S-439.", "evidence": [ { "database": "UniProtKB", "id": "Q99808", "url": "https://www.uniprot.org/uniprotkb/Q99808" }, { "database": "PubMed", "id": "21795683", "url": "https://pubmed.ncbi.nlm.nih.gov/21795683" } ], "uniprot_canonical_ac": "Q99808-1" } ], "record_id": "pubmed.21795683", "abstract": "", "glycosylation": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 5 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Functional analysis of purine nucleoside phosphorylase as a key enzyme in ribavirin metabolism.", "journal": "Drug metabolism and pharmacokinetics", "date": "2014", "authors": "Furihata T, Kishida S, Sugiura H, Kamiichi A, Iikura M, Chiba K", "reference": { "type": "PubMed", "id": "24107682", "url": "https://pubmed.ncbi.nlm.nih.gov/24107682" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43868-1", "protein_name": "Sodium/nucleoside cotransporter 2", "gene_name": "SLC28A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99808-1", "protein_name": "Equilibrative nucleoside transporter 1", "gene_name": "SLC29A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15531-1", "protein_name": "Nucleoside diphosphate kinase A", "gene_name": "NME1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BZD2-1", "protein_name": "Equilibrative nucleoside transporter 3", "gene_name": "SLC29A3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY32-1", "protein_name": "Inosine triphosphate pyrophosphatase", "gene_name": "ITPA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22392-1", "protein_name": "Nucleoside diphosphate kinase B", "gene_name": "NME1-NME2; NME2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55263-1", "protein_name": "Adenosine kinase", "gene_name": "ADK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00491-1", "protein_name": "Purine nucleoside phosphorylase", "gene_name": "PNP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HAS3-1", "protein_name": "Solute carrier family 28 member 3", "gene_name": "SLC28A3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49902-1", "protein_name": "Cytosolic purine 5'-nucleotidase", "gene_name": "NT5C2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00813-1", "protein_name": "Adenosine deaminase", "gene_name": "ADA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43868", "url": "https://www.uniprot.org/uniprotkb/O43868" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.24107682", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 11 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Ribavirin uptake into human hepatocyte HHL5 cells is enhanced by interferon-alpha via up-regulation of the human concentrative nucleoside transporter (hCNT2).", "journal": "Molecular pharmaceutics", "date": "2014", "authors": "Pinilla-Macua I, Fernandez-Calotti P, Perez-Del-Pulgar S, Pastor-Anglada M", "reference": { "type": "PubMed", "id": "24957263", "url": "https://pubmed.ncbi.nlm.nih.gov/24957263" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43868-1", "protein_name": "Sodium/nucleoside cotransporter 2", "gene_name": "SLC28A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99808-1", "protein_name": "Equilibrative nucleoside transporter 1", "gene_name": "SLC29A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15531-1", "protein_name": "Nucleoside diphosphate kinase A", "gene_name": "NME1", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Pharmacokinetics of ribavirin and urinary excretion of the major metabolite 1,2,4-triazole-3-carboxamide in normal volunteers.", "journal": "International journal of clinical pharmacology, therapy, and toxicology", "date": "1989", "authors": "Paroni R, Del Puppo M, Borghi C, Sirtori CR, Galli Kienle M", "reference": { "type": "PubMed", "id": "2737800", "url": "https://pubmed.ncbi.nlm.nih.gov/2737800" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43868-1", "protein_name": "Sodium/nucleoside cotransporter 2", "gene_name": "SLC28A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99808-1", "protein_name": "Equilibrative nucleoside transporter 1", "gene_name": "SLC29A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15531-1", "protein_name": "Nucleoside diphosphate kinase A", "gene_name": "NME1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BZD2-1", "protein_name": "Equilibrative nucleoside transporter 3", "gene_name": "SLC29A3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY32-1", "protein_name": "Inosine triphosphate pyrophosphatase", "gene_name": "ITPA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22392-1", "protein_name": "Nucleoside diphosphate kinase B", "gene_name": "NME1-NME2; NME2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55263-1", "protein_name": "Adenosine kinase", "gene_name": "ADK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00491-1", "protein_name": "Purine nucleoside phosphorylase", "gene_name": "PNP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HAS3-1", "protein_name": "Solute carrier family 28 member 3", "gene_name": "SLC28A3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49902-1", "protein_name": "Cytosolic purine 5'-nucleotidase", "gene_name": "NT5C2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00813-1", "protein_name": "Adenosine deaminase", "gene_name": "ADA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43868", "url": "https://www.uniprot.org/uniprotkb/O43868" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.2737800", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 11 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The relationship between the metabolism of ribavirin and its proposed mechanism of action.", "journal": "Annals of the New York Academy of Sciences", "date": "1977", "authors": "Miller JP, Kigwana LJ, Streeter DG, Robins RK, Simon LN, Roboz J", "reference": { "type": "PubMed", "id": "280136", "url": "https://pubmed.ncbi.nlm.nih.gov/280136" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43868-1", "protein_name": "Sodium/nucleoside cotransporter 2", "gene_name": "SLC28A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99808-1", "protein_name": "Equilibrative nucleoside transporter 1", "gene_name": "SLC29A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15531-1", "protein_name": "Nucleoside diphosphate kinase A", "gene_name": "NME1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BZD2-1", "protein_name": "Equilibrative nucleoside transporter 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"Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43868", "url": "https://www.uniprot.org/uniprotkb/O43868" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.280136", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 11 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Substituted cysteine accessibility method (SCAM) analysis of the transport domain of human concentrative nucleoside transporter 3 (hCNT3) and other family members reveals features of structural and functional importance.", "journal": "The Journal of biological chemistry", "date": "2017", "authors": "Mulinta R, Yao SYM, Ng AML, Cass CE, Young JD", "reference": { "type": "PubMed", "id": "28385889", "url": "https://pubmed.ncbi.nlm.nih.gov/28385889" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43868-1", "protein_name": "Sodium/nucleoside cotransporter 2", "gene_name": "SLC28A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00337-1", "protein_name": "Sodium/nucleoside cotransporter 1", "gene_name": "SLC28A1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43868", "url": "https://www.uniprot.org/uniprotkb/O43868" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.28385889", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Induction of inosine triphosphatase activity during ribavirin treatment for chronic hepatitis C.", "journal": "Clinica chimica acta; international journal of clinical chemistry", "date": "2018", "authors": "Tanaka Y, Yokomori H, Otori K", "reference": { "type": "PubMed", "id": "29580856", "url": "https://pubmed.ncbi.nlm.nih.gov/29580856" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43868-1", "protein_name": "Sodium/nucleoside cotransporter 2", "gene_name": "SLC28A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99808-1", "protein_name": "Equilibrative nucleoside transporter 1", "gene_name": "SLC29A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15531-1", "protein_name": "Nucleoside diphosphate kinase A", "gene_name": "NME1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BZD2-1", "protein_name": "Equilibrative nucleoside transporter 3", "gene_name": "SLC29A3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY32-1", "protein_name": "Inosine triphosphate pyrophosphatase", "gene_name": "ITPA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22392-1", 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"total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Inosine Triphosphate Pyrophosphatase Dephosphorylates Ribavirin Triphosphate and Reduced Enzymatic Activity Potentiates Mutagenesis in Hepatitis C Virus.", "journal": "Journal of virology", "date": "2018", "authors": "Nystrom K, Wanrooij PH, Waldenstrom J, Adamek L, Brunet S, Said J, Nilsson S, Wind-Rotolo M, Hellstrand K, Norder H, Tang KW, Lagging M", "reference": { "type": "PubMed", "id": "30045981", "url": "https://pubmed.ncbi.nlm.nih.gov/30045981" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43868-1", "protein_name": "Sodium/nucleoside cotransporter 2", "gene_name": "SLC28A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99808-1", "protein_name": "Equilibrative nucleoside transporter 1", "gene_name": "SLC29A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15531-1", "protein_name": "Nucleoside diphosphate kinase A", "gene_name": "NME1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BZD2-1", "protein_name": "Equilibrative nucleoside transporter 3", "gene_name": "SLC29A3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY32-1", "protein_name": "Inosine triphosphate pyrophosphatase", "gene_name": "ITPA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22392-1", "protein_name": "Nucleoside diphosphate kinase B", "gene_name": "NME1-NME2; NME2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P55263-1", "protein_name": "Adenosine kinase", "gene_name": "ADK", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00491-1", "protein_name": "Purine nucleoside phosphorylase", "gene_name": "PNP", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9HAS3-1", "protein_name": "Solute carrier family 28 member 3", "gene_name": "SLC28A3", "tax_name": "Human" }, { "uniprot_canonical_ac": "P49902-1", "protein_name": "Cytosolic purine 5'-nucleotidase", "gene_name": "NT5C2", "tax_name": "Human" }, { "uniprot_canonical_ac": "P00813-1", "protein_name": "Adenosine deaminase", "gene_name": "ADA", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43868", "url": "https://www.uniprot.org/uniprotkb/O43868" } ], "common_name": "Human", "glygen_name": 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"Hereditas", "date": "2019", "authors": "Zhou Z, Li Z, Wang C, Li X, Cheng X, Li C, Shi Y", "reference": { "type": "PubMed", "id": "30679935", "url": "https://pubmed.ncbi.nlm.nih.gov/30679935" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43868-1", "protein_name": "Sodium/nucleoside cotransporter 2", "gene_name": "SLC28A2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43868", "url": "https://www.uniprot.org/uniprotkb/O43868" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.30679935", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": 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"glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Transport of ribavirin across the rat and human placental barrier: Roles of nucleoside and ATP-binding cassette drug efflux transporters.", "journal": "Biochemical pharmacology", "date": "2019", "authors": "Karbanova S, Cerveny L, Jiraskova L, Karahoda R, Ceckova M, Ptackova Z, Staud F", "reference": { "type": "PubMed", "id": "30716294", "url": "https://pubmed.ncbi.nlm.nih.gov/30716294" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43868-1", "protein_name": "Sodium/nucleoside cotransporter 2", "gene_name": 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Role of nucleoside diphosphate kinase.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Bourdais J, Biondi R, Sarfati S, Guerreiro C, Lascu I, Janin J, Veron M", "reference": { "type": "PubMed", "id": "8626464", "url": "https://pubmed.ncbi.nlm.nih.gov/8626464" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43868-1", "protein_name": "Sodium/nucleoside cotransporter 2", "gene_name": "SLC28A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99808-1", "protein_name": "Equilibrative nucleoside transporter 1", "gene_name": "SLC29A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15531-1", "protein_name": "Nucleoside diphosphate kinase A", "gene_name": "NME1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BZD2-1", "protein_name": "Equilibrative nucleoside transporter 3", "gene_name": "SLC29A3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY32-1", "protein_name": "Inosine triphosphate pyrophosphatase", 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transporters.", "journal": "British journal of pharmacology", "date": "1998", "authors": "Jarvis SM, Thorn JA, Glue P", "reference": { "type": "PubMed", "id": "9605565", "url": "https://pubmed.ncbi.nlm.nih.gov/9605565" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43868-1", "protein_name": "Sodium/nucleoside cotransporter 2", "gene_name": "SLC28A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99808-1", "protein_name": "Equilibrative nucleoside transporter 1", "gene_name": "SLC29A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15531-1", "protein_name": "Nucleoside diphosphate kinase A", "gene_name": "NME1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BZD2-1", "protein_name": "Equilibrative nucleoside transporter 3", "gene_name": "SLC29A3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY32-1", "protein_name": "Inosine triphosphate pyrophosphatase", "gene_name": "ITPA", "tax_name": "Human" }, { "uniprot_canonical_ac": 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"authors": "Patil SD, Ngo LY, Glue P, Unadkat JD", "reference": { "type": "PubMed", "id": "9647364", "url": "https://pubmed.ncbi.nlm.nih.gov/9647364" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "O43868-1", "protein_name": "Sodium/nucleoside cotransporter 2", "gene_name": "SLC28A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99808-1", "protein_name": "Equilibrative nucleoside transporter 1", "gene_name": "SLC29A1", "tax_name": "Human" }, { "uniprot_canonical_ac": "P15531-1", "protein_name": "Nucleoside diphosphate kinase A", "gene_name": "NME1", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BZD2-1", "protein_name": "Equilibrative nucleoside transporter 3", "gene_name": "SLC29A3", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9BY32-1", "protein_name": "Inosine triphosphate pyrophosphatase", "gene_name": "ITPA", "tax_name": "Human" }, { "uniprot_canonical_ac": "P22392-1", "protein_name": "Nucleoside diphosphate kinase B", "gene_name": 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No effect on L-serine transport rate. Causes a shift of Na(+):L-serine transport stoichiometry from 1.2 to 2.", "evidence": [ { "database": "UniProtKB", "id": "P43007", "url": "https://www.uniprot.org/uniprotkb/P43007" }, { "database": "PubMed", "id": "24808181", "url": "https://pubmed.ncbi.nlm.nih.gov/24808181" } ], "uniprot_canonical_ac": "P43007-1" }, { "start_pos": 380, "end_pos": 380, "sequence_org": "D", "sequence_mut": "A", "comment": "Decreases the affinity for Na(+) ions and L-serine. Impairs L-serine transport.", "evidence": [ { "database": "UniProtKB", "id": "P43007", "url": "https://www.uniprot.org/uniprotkb/P43007" }, { "database": "PubMed", "id": "24808181", "url": "https://pubmed.ncbi.nlm.nih.gov/24808181" } ], "uniprot_canonical_ac": "P43007-1" }, { "start_pos": 380, "end_pos": 380, "sequence_org": "D", "sequence_mut": "N", "comment": "Decreases the affinity for Na(+) ions and L-serine. No effect on L-serine transport rate. 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No effect on L-serine transport rate.", "evidence": [ { "database": "UniProtKB", "id": "P43007", "url": "https://www.uniprot.org/uniprotkb/P43007" }, { "database": "PubMed", "id": "24808181", "url": "https://pubmed.ncbi.nlm.nih.gov/24808181" } ], "uniprot_canonical_ac": "P43007-1" }, { "start_pos": 465, "end_pos": 465, "sequence_org": "E", "sequence_mut": "L", "comment": "No effect on affinity for Na(+) ions. 2-fold reduction of L-serine transport rate; when associated with Asn-380.", "evidence": [ { "database": "UniProtKB", "id": "P43007", "url": "https://www.uniprot.org/uniprotkb/P43007" }, { "database": "PubMed", "id": "24808181", "url": "https://pubmed.ncbi.nlm.nih.gov/24808181" } ], "uniprot_canonical_ac": "P43007-1" }, { "start_pos": 467, "end_pos": 467, "sequence_org": "D", "sequence_mut": "A", "comment": "Decreases the affinity for Na(+) ions. Impairs L-serine transport.", "evidence": [ { "database": "UniProtKB", "id": "P43007", "url": "https://www.uniprot.org/uniprotkb/P43007" }, { "database": "PubMed", "id": "24808181", "url": "https://pubmed.ncbi.nlm.nih.gov/24808181" } ], "uniprot_canonical_ac": "P43007-1" }, { "start_pos": 467, "end_pos": 467, "sequence_org": "D", "sequence_mut": "N", "comment": "No effect on affinity for Na(+) ions. No effect on Na(+):L-serine transport stoichiometry. 3-fold decreased L-serine transport rate.", "evidence": [ { "database": "UniProtKB", "id": "P43007", "url": "https://www.uniprot.org/uniprotkb/P43007" }, { "database": "PubMed", "id": "24808181", "url": "https://pubmed.ncbi.nlm.nih.gov/24808181" } ], "uniprot_canonical_ac": "P43007-1" }, { "start_pos": 467, "end_pos": 467, "sequence_org": "D", "sequence_mut": "S", "comment": "No effect on affinity for Na(+) ions. No effect on L-serine transport rate and Na(+):L-serine transport stoichiometry. Decreases the affinity for Na(+) ions by 2-fold, increases L-serine-induced anion conductance by 3.8 fold and impairs L-serine transport; when associated with Asn-380.", "evidence": [ { "database": "UniProtKB", "id": "P43007", "url": "https://www.uniprot.org/uniprotkb/P43007" }, { "database": "PubMed", "id": "24808181", "url": "https://pubmed.ncbi.nlm.nih.gov/24808181" } ], "uniprot_canonical_ac": "P43007-1" }, { "start_pos": 467, "end_pos": 467, "sequence_org": "D", "sequence_mut": "T", "comment": "Decreases the affinity for Na(+) ions. 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"count": 0 } ], "sort_fields": [] } ] }, { "title": "A homozygous mutation in SLC1A4 in siblings with severe intellectual disability and microcephaly.", "journal": "Clinical genetics", "date": "2015", "authors": "Srour M, Hamdan FF, Gan-Or Z, Labuda D, Nassif C, Oskoui M, Gana-Weisz M, Orr-Urtreger A, Rouleau GA, Michaud JL", "reference": { "type": "PubMed", "id": "25930971", "url": "https://pubmed.ncbi.nlm.nih.gov/25930971" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P43007-1", "protein_name": "Neutral amino acid transporter A", "gene_name": "SLC1A4", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q9Y620-1", "protein_name": "DNA repair and recombination protein RAD54B", "gene_name": "RAD54B", "tax_name": "Human" }, { "uniprot_canonical_ac": "O00187-1", "protein_name": "Mannan-binding lectin serine protease 2", "gene_name": "MASP2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Mutations in SLC1A4, encoding the brain serine transporter, are associated with developmental delay, microcephaly and hypomyelination.", "journal": "Journal of medical genetics", "date": "2015", "authors": "Damseh N, Simonin A, Jalas C, Picoraro JA, Shaag A, Cho MT, Yaacov B, Neidich J, Al-Ashhab M, Juusola J, Bale S, Telegrafi A, Retterer K, Pappas JG, Moran E, Cappell J, Anyane Yeboa K, Abu-Libdeh B, Hediger MA, Chung WK, Elpeleg O, Edvardson S", "reference": { "type": "PubMed", "id": "26041762", "url": "https://pubmed.ncbi.nlm.nih.gov/26041762" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P43007-1", "protein_name": "Neutral amino acid transporter A", "gene_name": "SLC1A4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P43007", "url": "https://www.uniprot.org/uniprotkb/P43007" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": 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}, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "SLC1A4 mutations cause a novel disorder of intellectual disability, progressive microcephaly, spasticity and thin corpus callosum.", "journal": "Clinical genetics", "date": "2015", "authors": "Heimer G, Marek-Yagel D, Eyal E, Barel O, Oz Levi D, Hoffmann C, Ruzzo EK, Ganelin-Cohen E, Lancet D, Pras E, Rechavi G, Nissenkorn A, Anikster Y, Goldstein DB, Ben Zeev B", "reference": { "type": "PubMed", "id": "26138499", "url": "https://pubmed.ncbi.nlm.nih.gov/26138499" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P43007-1", "protein_name": "Neutral amino acid transporter A", "gene_name": "SLC1A4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P43007", "url": "https://www.uniprot.org/uniprotkb/P43007" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.26138499", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Phenylglycine analogs are inhibitors of the neutral amino acid transporters ASCT1 and ASCT2 and enhance NMDA receptor-mediated LTP in rat visual cortex slices.", "journal": "Neuropharmacology", "date": "2017", "authors": "Foster AC, Rangel-Diaz N, Staubli U, Yang JY, Penjwini M, Viswanath V, Li YX", "reference": { "type": "PubMed", "id": "28807674", "url": "https://pubmed.ncbi.nlm.nih.gov/28807674" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P43007-1", "protein_name": "Neutral amino acid transporter A", "gene_name": "SLC1A4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P43007", "url": "https://www.uniprot.org/uniprotkb/P43007" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.28807674", "abstract": 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Aduri Nanda Gowtham, Marrink Siewert J, Gati Cornelius, Guskov Albert", "reference": { "type": "PubMed", "id": "34630942", "url": "https://pubmed.ncbi.nlm.nih.gov/34630942" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P43007-1", "protein_name": "Neutral amino acid transporter A", "gene_name": "SLC1A4", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P43007", "url": "https://www.uniprot.org/uniprotkb/P43007" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.34630942", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", 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"Homo sapiens [9606]" } ], "record_id": "pubmed.8626564", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 3 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", 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{ "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "The structural organization of the human Na+/myo-inositol cotransporter (SLC5A3) gene and characterization of the promoter.", "journal": "Genomics", "date": "1997", "authors": "Mallee JJ, Atta MG, Lorica V, Rim JS, Kwon HM, Lucente AD, Wang Y, Berry GT", "reference": { "type": "PubMed", "id": "9441750", "url": "https://pubmed.ncbi.nlm.nih.gov/9441750" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "P53794-1", "protein_name": "Sodium/myo-inositol cotransporter", "gene_name": "SLC5A3", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "P53794", "url": "https://www.uniprot.org/uniprotkb/P53794" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.9441750", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Kinetic and pharmacological properties of cloned human equilibrative nucleoside transporters, ENT1 and ENT2, stably expressed in nucleoside transporter-deficient PK15 cells. Ent2 exhibits a low affinity for guanosine and cytidine but a high affinity for inosine.", "journal": "The Journal of biological chemistry", "date": "2000-03-24", "authors": "Ward J L, Sherali A, Mo Z P, Tse C M", "reference": { "type": "PubMed", "id": "10722669", "url": "https://pubmed.ncbi.nlm.nih.gov/10722669" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q14542-1", "protein_name": "Equilibrative nucleoside transporter 2", "gene_name": "SLC29A2", "tax_name": "Human" }, { "uniprot_canonical_ac": "Q99808-1", "protein_name": "Equilibrative nucleoside transporter 1", "gene_name": "SLC29A1", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q14542", "url": "https://www.uniprot.org/uniprotkb/Q14542" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.10722669", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 2 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells.", "journal": "American journal of physiology. 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"tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Functional analysis of site-directed glycosylation mutants of the human equilibrative nucleoside transporter-2.", "journal": "Archives of biochemistry and biophysics", "date": "2003", "authors": "Ward JL, Leung GP, Toan SV, Tse CM", "reference": { "type": "PubMed", "id": "12590919", "url": "https://pubmed.ncbi.nlm.nih.gov/12590919" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q14542-1", "protein_name": "Equilibrative nucleoside transporter 2", "gene_name": "SLC29A2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q14542", "url": "https://www.uniprot.org/uniprotkb/Q14542" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "other", "prediction_tool_list": [], "site_category": "reported", "site_category_dict": { "reported": true, "automatic_literature_mining": true }, "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "icn3d_view": {}, "start_pos": 48, "start_aa": "Asn", "end_pos": 48, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn48", "evidence": [ { "id": "Q14542", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprotkb/Q14542#ptm_processing" }, { "id": "12590919", "database": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/12590919" }, { "id": "24190977", "database": "PubMed", "url": 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No differences in Km values and lower Vmax values for either uridine or cytidine uptake; when associated with D-57.", "evidence": [ { "database": "UniProtKB", "id": "Q14542", "url": "https://www.uniprot.org/uniprotkb/Q14542" }, { "database": "PubMed", "id": "12590919", "url": "https://pubmed.ncbi.nlm.nih.gov/12590919" } ], "uniprot_canonical_ac": "Q14542-1" }, { "start_pos": 57, "end_pos": 57, "sequence_org": "N", "sequence_mut": "D", "comment": "No difference in uridine or cytidine uptake. No differences in Km values and lower Vmax values for either uridine or cytidine uptake; when associated with D-48.", "evidence": [ { "database": "UniProtKB", "id": "Q14542", "url": "https://www.uniprot.org/uniprotkb/Q14542" }, { "database": "PubMed", "id": "12590919", "url": "https://pubmed.ncbi.nlm.nih.gov/12590919" } ], "uniprot_canonical_ac": "Q14542-1" } ], "record_id": "pubmed.12590919", "abstract": "", "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] }, { "table_id": "referenced_glycans", "table_stats": [ { "field": "total", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_sites", "count": 2 }, { "field": "o_linked_sites", "count": 0 }, { "field": 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0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "exact_sites", "count": 2 }, { "field": "exact_n_linked_sites", "count": 2 }, { "field": "fuzzy_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl", "mining_tool", "filter_code", "uniprot_canonical_ac" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { 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"start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl", "mining_tool", "filter_code", "uniprot_canonical_ac" ] } ] }, { "title": "Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2.", "journal": "Drug metabolism and disposition: the biological fate of chemicals", "date": "2006-01", "authors": "Owen Ryan P, Lagpacan Leah L, Taylor Travis R, De La Cruz Melanie, Huang Conrad C, Kawamoto Michiko, Johns Susan J, Stryke Doug, Ferrin Thomas E, Giacomini Kathleen M", "reference": { "type": "PubMed", "id": "16214850", "url": "https://pubmed.ncbi.nlm.nih.gov/16214850" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q14542-1", "protein_name": "Equilibrative nucleoside transporter 2", "gene_name": "SLC29A2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q14542", "url": 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"sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_sites", "count": 0 }, { "field": "o_linked_sites", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Novel nuclear hENT2 isoforms regulate cell cycle progression via controlling nucleoside transport and nuclear reservoir.", "journal": "Cell. Mol. Life Sci.", "date": "2016", "authors": "Grane-Boladeras N, Spring CM, Hanna WJ, Pastor-Anglada M, Coe IR", "reference": { "type": "PubMed", "id": "27271752", "url": "https://pubmed.ncbi.nlm.nih.gov/27271752" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q14542-1", "protein_name": "Equilibrative nucleoside transporter 2", "gene_name": "SLC29A2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q14542", "url": "https://www.uniprot.org/uniprotkb/Q14542" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], "record_id": "pubmed.27271752", "abstract": "", "glycosylation": [], "mutagenesis": [], "snv": [], "phosphorylation": [], "glycation": [], "section_stats": [ { "table_id": "referenced_proteins", "table_stats": [ { "field": "total", "count": 1 } ], "sort_fields": [ "uniprot_canonical_ac", "protein_name", "gene_name", "tax_name" ] 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"count": 0 }, { "field": "o_linked_glycans", "count": 0 } ], "sort_fields": [] } ] }, { "title": "Exosomes secreted from cancer-associated fibroblasts elicit anti-pyrimidine drug resistance through modulation of its transporter in malignant lymphoma.", "journal": "Oncogene", "date": "2021", "authors": "Kunou S, Shimada K, Takai M, Sakamoto A, Aoki T, Hikita T, Kagaya Y, Iwamoto E, Sanada M, Shimada S, Hayakawa F, Oneyama C, Kiyoi H", "reference": { "type": "PubMed", "id": "33994542", "url": "https://pubmed.ncbi.nlm.nih.gov/33994542" }, "referenced_glycans": [], "referenced_proteins": [ { "uniprot_canonical_ac": "Q14542-1", "protein_name": "Equilibrative nucleoside transporter 2", "gene_name": "SLC29A2", "tax_name": "Human" } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "Q14542", "url": "https://www.uniprot.org/uniprotkb/Q14542" } ], "common_name": "Human", "glygen_name": "Human", "reference_species": "Homo sapiens [9606]" } ], 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