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        "title": "Uptake and fate of class B scavenger receptor ligands in HepG2 cells.",
        "journal": "European journal of biochemistry",
        "date": "1999",
        "authors": "Rhainds D, Falstrault L, Tremblay C, Brissette L",
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        "title": "Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex.",
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    {
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        "authors": "Hutt JA, O'Rourke JP, DeWille J",
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        "title": "A stat-responsive element in the promoter of the episialin/MUC1 gene is involved in its overexpression in carcinoma cells.",
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        "title": "Direct regulation of pituitary proopiomelanocortin by STAT3 provides a novel mechanism for immuno-neuroendocrine interfacing.",
        "journal": "The Journal of clinical investigation",
        "date": "2000",
        "authors": "Bousquet C, Zatelli MC, Melmed S",
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            "url": "https://pubmed.ncbi.nlm.nih.gov/11104795"
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    {
        "title": "c-Jun and c-Fos cooperate with STAT3 in IL-6-induced transactivation of the IL-6 respone element (IRE).",
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        "date": "2001",
        "authors": "Schuringa JJ, Timmer H, Luttickhuizen D, Vellenga E, Kruijer W",
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        "title": "Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis.",
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    {
        "title": "Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis.",
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        "date": "2002",
        "authors": "Niu G, Wright KL, Huang M, Song L, Haura E, Turkson J, Zhang S, Wang T, Sinibaldi D, Coppola D, Heller R, Ellis LM, Karras J, Bromberg J, Pardoll D, Jove R, Yu H",
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    {
        "title": "Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation.",
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        "authors": "Seki Y, Hayashi K, Matsumoto A, Seki N, Tsukada J, Ransom J, Naka T, Kishimoto T, Yoshimura A, Kubo M",
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                "uniprot_canonical_ac": "P27930-1",
                "protein_name": "Interleukin-1 receptor type 2",
                "gene_name": "IL1R2",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P15018-1",
                "protein_name": "Leukemia inhibitory factor",
                "gene_name": "LIF",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P03956-1",
                "protein_name": "Interstitial collagenase",
                "gene_name": "MMP1",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P14859-1",
                "protein_name": "POU domain, class 2, transcription factor 1",
                "gene_name": "POU2F1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "O15392-1",
                "protein_name": "Baculoviral IAP repeat-containing protein 5",
                "gene_name": "BIRC5",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P41143-1",
                "protein_name": "Delta-type opioid receptor",
                "gene_name": "OPRD1",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P11309-1",
                "protein_name": "Serine/threonine-protein kinase pim-1",
                "gene_name": "PIM1",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P01033-1",
                "protein_name": "Metalloproteinase inhibitor 1",
                "gene_name": "TIMP1",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P33681-1",
                "protein_name": "T-lymphocyte activation antigen CD80",
                "gene_name": "CD80",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P06734-1",
                "protein_name": "Low affinity immunoglobulin epsilon Fc receptor",
                "gene_name": "FCER2",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "Q07817-1",
                "protein_name": "Bcl-2-like protein 1",
                "gene_name": "BCL2L1",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q16520-1",
                "protein_name": "Basic leucine zipper transcriptional factor ATF-like",
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                "protein_name": "Pro-opiomelanocortin",
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                "tax_name": "Human"
            },
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            },
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                "uniprot_canonical_ac": "P09038-4",
                "protein_name": "Fibroblast growth factor 2",
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            },
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                "protein_name": "C-C motif chemokine 3",
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            },
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            },
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            },
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                "protein_name": "Polyunsaturated fatty acid lipoxygenase ALOX15",
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                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P52333-1",
                "protein_name": "Tyrosine-protein kinase JAK3",
                "gene_name": "JAK3",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P04141-1",
                "protein_name": "Granulocyte-macrophage colony-stimulating factor",
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            },
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                "protein_name": "Laminin subunit alpha-5",
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            },
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            },
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                "protein_name": "Immunoglobulin heavy constant gamma 4",
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                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "Q14116-1",
                "protein_name": "Interleukin-18",
                "gene_name": "IL18",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "Q16552-1",
                "protein_name": "Interleukin-17A",
                "gene_name": "IL17A",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P08670-1",
                "protein_name": "Vimentin",
                "gene_name": "VIM",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "O43524-1",
                "protein_name": "Forkhead box protein O3",
                "gene_name": "FOXO3",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P11142-1",
                "protein_name": "Heat shock cognate 71 kDa protein",
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                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "Q16658-1",
                "protein_name": "Fascin",
                "gene_name": "FSCN1",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P31749-1",
                "protein_name": "RAC-alpha serine/threonine-protein kinase",
                "gene_name": "AKT1",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P10415-1",
                "protein_name": "Apoptosis regulator Bcl-2",
                "gene_name": "BCL2",
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            },
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                "uniprot_canonical_ac": "Q07820-1",
                "protein_name": "Induced myeloid leukemia cell differentiation protein Mcl-1",
                "gene_name": "MCL1",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P23771-1",
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            },
            {
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                "gene_name": "HSP90AA1",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P41182-1",
                "protein_name": "B-cell lymphoma 6 protein",
                "gene_name": "BCL6",
                "tax_name": "Human"
            },
            {
                "uniprot_canonical_ac": "P24385-1",
                "protein_name": "G1/S-specific cyclin-D1",
                "gene_name": "CCND1",
                "tax_name": "Human"
            },
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                "protein_name": "Integrin beta-1",
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            },
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                "protein_name": "Collagen alpha-2(I) chain",
                "gene_name": "COL1A2",
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            },
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                "protein_name": "Granulocyte colony-stimulating factor",
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            },
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                "protein_name": "Matrix metalloproteinase-9",
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                "tax_name": "Human"
            },
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                "protein_name": "Interleukin-8",
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                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P29597-1",
                "protein_name": "Non-receptor tyrosine-protein kinase TYK2",
                "gene_name": "TYK2",
                "tax_name": "Human"
            },
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                "uniprot_canonical_ac": "P35228-1",
                "protein_name": "Nitric oxide synthase, inducible",
                "gene_name": "NOS2",
                "tax_name": "Human"
            },
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            },
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                "uniprot_canonical_ac": "P37275-1",
                "protein_name": "Zinc finger E-box-binding homeobox 1",
                "gene_name": "ZEB1",
                "tax_name": "Human"
            },
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                "protein_name": "Hepatocyte growth factor",
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                "tax_name": "Human"
            },
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                "protein_name": "Twist-related protein 1",
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            },
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            },
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                "protein_name": "Tumor necrosis factor",
                "gene_name": "TNF",
                "tax_name": "Human"
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                "protein_name": "Neutrophil gelatinase-associated lipocalin",
                "gene_name": "LCN2",
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                "protein_name": "C-C motif chemokine 3-like 1",
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                "name": "Homo sapiens",
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                "glygen_name": "Human",
                "reference_species": "Homo sapiens [9606]"
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        ],
        "record_id": "pubmed.12832402",
        "abstract": "",
        "glycosylation": [],
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        "title": "Endocytosis is not required for the selective lipid uptake mediated by murine SR-BI.",
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    {
        "title": "Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways.",
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    {
        "title": "A role for human Sp alpha as a pattern recognition receptor.",
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        "authors": "Sarrias Maria-Rosa, Rosell\u00f3 Sandra, S\u00e1nchez-Barbero Fernando, Sierra Josep M, Vila Jordi, Y\u00e9lamos Jos\u00e9, Vives Jordi, Casals Cristina, Lozano Francisco",
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        "title": "STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells.",
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        "title": "Requirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cells.",
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    {
        "title": "Serum amyloid A as a tumor marker in sera of nude mice with orthotopic human pancreatic cancer and in plasma of patients with pancreatic cancer.",
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    {
        "title": "Essential role of STAT3 in cytokine-driven NF-kappaB-mediated serum amyloid A gene expression.",
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        "authors": "Hagihara K, Nishikawa T, Sugamata Y, Song J, Isobe T, Taga T, Yoshizaki K",
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    {
        "title": "Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells.",
        "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research",
        "date": "2006",
        "authors": "Gritsko T, Williams A, Turkson J, Kaneko S, Bowman T, Huang M, Nam S, Eweis I, Diaz N, Sullivan D, Yoder S, Enkemann S, Eschrich S, Lee JH, Beam CA, Cheng J, Minton S, Muro-Cacho CA, Jove R",
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    {
        "title": "SOCS1: a potent and multifaceted regulator of cytokines and cell-mediated inflammation.",
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        "title": "Two novel rat liver membrane proteins that bind advanced glycosylation endproducts: relationship to macrophage receptor for glucose-modified proteins.",
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        "title": "Signaling mechanisms, interaction partners, and target genes of STAT6.",
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        "title": "Diverse effects of Stat1 on the regulation of hsp90alpha gene under heat shock.",
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    {
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    {
        "title": "Regulation of Sox2 by STAT3 initiates commitment to the neural precursor cell fate.",
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        "authors": "Foshay KM, Gallicano GI",
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        "title": "Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment.",
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                        "url": "https://disease-ontology.org/term/DOID:1324",
                        "name": "lung cancer",
                        "description": "A respiratory system cancer that is located_in the lung."
                    },
                    "name_list": [
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                        "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                        "adenocarcinoma of lung, somatic",
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                        "lung cancer, protection against, autosomal dominant, somatic mutation",
                        "lung cancer, resistance to, autosomal dominant, somatic mutation",
                        "lung cancer, somatic",
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                        "malignant lung tumour",
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                        "malignant tumour of lung",
                        "malignant tumour of the lung",
                        "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
                        "nonsmall cell lung cancer, somatic",
                        "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
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                        "lung cancer susceptibility",
                        "lung cancer susceptibility 3",
                        "LNCR3",
                        "lung cancer susceptibility 4",
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                        "MONDO:0008903",
                        "MONDO:0012159",
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                        "MONDO:0012955",
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    {
        "title": "STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors.",
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    {
        "title": "STAT3 protein promotes T-cell survival and inhibits interleukin-2 production through up-regulation of Class O Forkhead transcription factors.",
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