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        "authors": "Mahmood Fahad, Fu Sonia, Cooke Jennifer, Wilson Stephen W, Cooper Jonathan D, Russell Claire",
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                "comment": "In sa0011; Lethality occurs from 4 days post-fertilization (dpf) onwards with no survival beyond 7 dpf. Severe developmental abnormalities are apparent from 48 hours post-fertilization (hpf) onwards including curved body, small head and a progressive reduction in eye size. At later stages there are signs of pericardial edema and the swim bladder is absent. Neurodegeneration is present in the retina, optic tectum and cerebellum, associated with increased apoptosis and reduced cell proliferation. Locomotor behavior is abnormal with increased movement, aberrant swimming patterns and a twitching phenotype. Significantly reduced peptidase activity and accumulation of the tpp1 substrate, subunit c of mitochondrial ATP synthase.",
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        "authors": "Dekens Marcus P S, Pelegri Francisco J, Maischein Hans-Martin, N\u00fcsslein-Volhard Christiane",
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