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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0035091 phosphatidylinositol binding;GO:0070300 phosphatidic acid binding",
        "go_cellular_component": "GO:0005912 adherens junction;GO:0016324 apical plasma membrane;GO:0043296 apical junction complex;GO:0005915 zonula adherens;GO:0005914 spot adherens junction",
        "go_biological_process": "GO:0035089 establishment of apical/basal cell polarity;GO:0007416 synapse assembly;GO:0034332 adherens junction organization;GO:0051490 negative regulation of filopodium assembly;GO:0060446 branching involved in open tracheal system development",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q0KHR3-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q0E9H9-1",
        "uniprot_id": [
            {
                "id": "DSCA1_DROME",
                "url": "https://www.uniprot.org/uniprot/Q0E9H9",
                "type": "external"
            }
        ],
        "mass": 222102.0,
        "length": 2016,
        "protein_name": "Cell adhesion molecule Dscam1",
        "gene_name": "Dscam1",
        "organism": "Fruit fly",
        "refseq_name": "down syndrome cell adhesion molecule 1, isoform Y",
        "refseq_ac": [
            {
                "id": "NP_001036491",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036491",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dscam1; 43Bc; CG17800; CT39257; DSCAM1; DSCAM; DScam; DmDscam; Dm_2R:13579; Dm_2R:13612; Dmel\\CG17800; Dmel_CG17800; DsCam; Dscam-hv; Dscam; Dsm; Neu1; dScam; dscam1; dscam; l(2)05518; l(2)43Bc; p270",
        "gene_names_refseq": "43Bc; CG17800; CT39257; DSCAM1; DSCAM; DScam; DmDscam; Dm_2R:13579; Dm_2R:13612; Dmel\\CG17800; DsCam; Dscam-hv; Dscam1; Dscam; Dsm; Neu1; dScam; dscam1; dscam; l(2)05518; l(2)43Bc; p270",
        "protein_names_uniprotkb": "Cell adhesion molecule Dscam1; Down syndrome cell adhesion molecule homolog",
        "protein_names_refseq": "CG17800-PY; Down's syndrome cell adhesion molecule; Dscam1-PY; down syndrome cell adhesion molecule 1, isoform Y; down syndrome cell adhesion molecule; down syndrome cell-adhesion molecule; drosophila down syndrome cell adhesion molecule 1; dscam; lethal(2)43Bc",
        "tax_id": 7227,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); ocular motor apraxia, Cogan type (Disease Ontology:DOID:0080849); ocular motility disease (Disease Ontology:DOID:1279); Down syndrome (Disease Ontology:DOID:14250)",
        "pathway": " (dme:Dmel_CG17800)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "10731132;10892653;11856530;12014990;12537568;12537572;12537573;12537574;14758360;15339648;15339666;16109846;16110336;17482551;17569856;17569867;17721508;17889655;18805093;25589440;26109356;26109357;27386517",
        "class_list": "",
        "function": "Cell surface receptor involved in guidance and targeting of growing nerve axons (PubMed:10892653). Required during Bolwig's organ differentiation for accurate and efficient targeting of photoreceptor neuron axons to their synaptic targets in the brain via the P2 intermediate target neuron (PubMed:10892653). Involved in isoneural self-avoidance during dendrite arborization but not in heteroneural recognition and repulsion during tiling by related neurons of the same class (PubMed:17482551). Involved in regulating axon bifurcation and divergent extension in the developing mushroom body (PubMed:11856530, PubMed:15339648). Essential for axon arborization in ellipsoid body (PubMed:11856530, PubMed:15339648). Exhibits an extraordinary level of molecular diversity resulting from alternative splicing (PubMed:10892653). Isoforms differing in their ectodomain makeup show a high degree of functional redundancy while isoforms with different transmembrane domains are involved in different neuronal morphogenetic processes and are differentially targeted to dendrites or axons (PubMed:15339648). The vast majority of isoforms exhibit strong isoform-specific homophilic binding (PubMed:15339666, PubMed:17889655). Individual cells express a distinct randomly generated repertoire of isoforms (PubMed:14758360). Cell surfaces bearing identical repertoires of Dscam1 isoforms, such as those from the same cell, trigger recognition and avoidance (PubMed:17482551). A subset of isoforms is expressed in fat body cells and hemocytes, cells that are part of the insect immune response, and these isoforms are secreted into the hemolymph (PubMed:16109846). The secreted form comprising the ectodomain can bind to bacteria, such as Escherichia coli, and may act as an opsonin enhancing their phagocytosis by hemocytes (PubMed:16109846)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 8,
        "predicted_n_glycosites": 4,
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        "glyco_site_count": 12,
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        "secondary_ac_list": "A0A0B4K6Z6;Q0E9H6;Q0E9H8;Q0E9I4;Q0E9J0;Q0E9J7;Q0E9J8;Q0E9J9;Q0E9K4;Q0E9K7;Q0E9K9;Q0E9L0;Q0E9L5;Q9NBA1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0003823 antigen binding;GO:0008046 axon guidance receptor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body",
        "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0021551 central nervous system morphogenesis;GO:0050976 detection of mechanical stimulus involved in sensory perception of touch;GO:0007155 cell adhesion;GO:0048814 regulation of dendrite morphogenesis",
        "synthesized_glycan_count": 0,
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        "record_type": "protein",
        "filter_code": "0000000.0100111.010000.000000100000000000.1000000011000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VB15-1",
        "uniprot_id": [
            {
                "id": "Q9VB15_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VB15",
                "type": "external"
            }
        ],
        "mass": 77997.0,
        "length": 717,
        "protein_name": "Microtubule-associated protein",
        "gene_name": "tau",
        "organism": "Fruit fly",
        "refseq_name": "tau, isoform G",
        "refseq_ac": [
            {
                "id": "NP_733224",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_733224",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "tau; BcDNA:RE16764; CG12881; CG31057; CG31058; CG34294; CG45110; CG5606; Dmel\\CG45110; Dmel_CG45110; Tau; d-tau; dTAU; dTau; dtau; tao",
        "gene_names_refseq": "BcDNA:RE16764; CG12881; CG31057; CG31058; CG34294; CG45110; CG5606; Dmel\\CG45110; Tau; d-tau; dTAU; dTau; dtau; tao; tau",
        "protein_names_uniprotkb": "Microtubule-associated protein",
        "protein_names_refseq": "CG45110-PG; tau, isoform G; tau-PG",
        "tax_id": 7227,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741); frontotemporal dementia 1 (Disease Ontology:DOID:0051060); late onset Parkinson's disease (Disease Ontology:DOID:0060892); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); Alzheimer's disease (Disease Ontology:DOID:10652); amnestic disorder (Disease Ontology:DOID:10914); Pick's disease (Disease Ontology:DOID:11870); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); neurodegenerative disease (Disease Ontology:DOID:1289); dementia (Disease Ontology:DOID:1307); Parkinson's disease (Disease Ontology:DOID:14330); cognitive disorder (Disease Ontology:DOID:1561); breast cancer (Disease Ontology:DOID:1612); epilepsy (Disease Ontology:DOID:1826); brain ischemia (Disease Ontology:DOID:2316); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); progressive supranuclear palsy (Disease Ontology:DOID:678); tauopathy (Disease Ontology:DOID:680); vascular dementia (Disease Ontology:DOID:8725); frontotemporal dementia (Disease Ontology:DOID:9255); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (dme:Dmel_CG45110);  (R-DME-264870)",
        "pathway_count": 2,
        "publication_count": 11,
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        "go_molecular_function": "GO:0008017 microtubule binding",
        "go_cellular_component": "GO:0005874 microtubule;GO:0030424 axon;GO:0030425 dendrite;GO:0005856 cytoskeleton;GO:0043005 neuron projection",
        "go_biological_process": "GO:0000226 microtubule cytoskeleton organization;GO:0061541 rhabdomere morphogenesis;GO:0031175 neuron projection development;GO:0060446 branching involved in open tracheal system development;GO:0035149 lumen formation, open tracheal system",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
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        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9V435-1",
        "uniprot_id": [
            {
                "id": "Q9V435_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9V435",
                "type": "external"
            }
        ],
        "mass": 101860.0,
        "length": 890,
        "protein_name": "Yuri gagarin, isoform B",
        "gene_name": "yuri",
        "organism": "Fruit fly",
        "refseq_name": "yuri gagarin, isoform B",
        "refseq_ac": [
            {
                "id": "NP_723903",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_723903",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "yuri; BG:DS05639.1; BG:DS07851.11; CG11860; CG12635; CG31732; Dmel\\CG31732; Dmel_CG31732; Yuri",
        "gene_names_refseq": "BG:DS05639.1; BG:DS07851.11; CG11860; CG12635; CG31732; Dmel\\CG31732; Yuri; yuri",
        "protein_names_uniprotkb": "Yuri gagarin, isoform B",
        "protein_names_refseq": "CG31732-PB; yuri gagarin, isoform B; yuri gagarin; yuri-PB",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG31732);  (R-DME-352238);  (R-DME-4419969);  (R-DME-9035034)",
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        "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton",
        "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005652 nuclear lamina;GO:0070865 investment cone",
        "go_biological_process": "GO:0042332 gravitaxis;GO:0090435 protein localization to nuclear envelope;GO:0006998 nuclear envelope organization;GO:0007291 sperm individualization;GO:0031507 heterochromatin formation",
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    {
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                "id": "Q9VHR2_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VHR2",
                "type": "external"
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        ],
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        "length": 1876,
        "protein_name": "Ig-like domain-containing protein",
        "gene_name": "CG11729; CG42286; CT32186; GS3056; MRE1; anon-EST:Posey178",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform E",
        "refseq_ac": [
            {
                "id": "NP_731246",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_731246",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CG11729; CG42286; CT32186; GS3056; MRE1; anon-EST:Posey178; 43462; BcDNA:AT05815; BcDNA:GH22170; CG11718; CG11729; CG11730; CG11731; CG11733; CG31264; CG31369; CG31462; CG42285; CG42286; CG43462; CG45263; CT32186; Dmel\\CG45263; Dmel_CG45263; GH22170; GS3056; MRE1; anon-EST:Posey178",
        "gene_names_refseq": "43462; BcDNA:AT05815; BcDNA:GH22170; CG11718; CG11729; CG11730; CG11731; CG11733; CG31264; CG31369; CG31462; CG42285; CG42286; CG43462; CG45263; CT32186; Dmel\\CG45263; GH22170; GS3056; MRE1; anon-EST:Posey178",
        "protein_names_uniprotkb": "Ig-like domain-containing protein",
        "protein_names_refseq": "CG45263-PE; mRNA-like ncRNA in embryogenesis 1; uncharacterized protein, isoform E",
        "tax_id": 7227,
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        "pathway": " (dme:Dmel_CG45263);  (R-DME-373753)",
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        "go_molecular_function": "GO:0050839 cell adhesion molecule binding",
        "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0005911 cell-cell junction",
        "go_biological_process": "GO:0098609 cell-cell adhesion",
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        "hit_score": 1.6,
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    },
    {
        "uniprot_canonical_ac": "M9NFQ7-1",
        "uniprot_id": [
            {
                "id": "M9NFQ7_DROME",
                "url": "https://www.uniprot.org/uniprot/M9NFQ7",
                "type": "external"
            }
        ],
        "mass": 96880.0,
        "length": 962,
        "protein_name": "RNA-binding Fox protein 1, isoform H",
        "gene_name": "Rbfox1",
        "organism": "Fruit fly",
        "refseq_name": "RNA-binding Fox protein 1, isoform H",
        "refseq_ac": [
            {
                "id": "NP_001246707",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246707",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Rbfox1; A2BP1; A2bp1; BcDNA:GM06073; CG14155; CG18441; CG32062; Dmel\\CG32062; Dmel_CG32062; Rbox1; cg18441; dA2BP1; rbfox1",
        "gene_names_refseq": "A2BP1; A2bp1; BcDNA:GM06073; CG14155; CG18441; CG32062; Dmel\\CG32062; Rbfox1; Rbox1; cg18441; dA2BP1; rbfox1",
        "protein_names_uniprotkb": "RNA-binding Fox protein 1, isoform H",
        "protein_names_refseq": "Ataxin-2 binding protein 1; CG32062-PH; RNA-binding Fox protein 1, isoform H; Rbfox1-PH; ataxin 2-binding protein 1",
        "tax_id": 7227,
        "disease": "intellectual disability (Disease Ontology:DOID:1059); hypertension (Disease Ontology:DOID:10763); myotonic dystrophy type 1 (Disease Ontology:DOID:11722); dilated cardiomyopathy (Disease Ontology:DOID:12930); alcohol use disorder (Disease Ontology:DOID:1574); congenital heart disease (Disease Ontology:DOID:1682); brain infarction (Disease Ontology:DOID:3454); middle cerebral artery infarction (Disease Ontology:DOID:3525); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypoplastic left heart syndrome (Disease Ontology:DOID:9955)",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 11,
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                "id": "M9PF47_DROME",
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        "refseq_name": "forkhead box K, isoform N",
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            {
                "id": "NP_001261701",
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            }
        ],
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        "gene_names_refseq": "CG11799; DmLD16137; DmMNF; Dmel\\CG11799; FoxK; MNF; Mnf; dFoxK; fd68A; fork head transcription factor long isoform; fork head transcription factor short isoform",
        "protein_names_uniprotkb": "Forkhead box K, isoform N",
        "protein_names_refseq": "CG11799-PN; FoxK-PN; Mnf; fork head box K; forkhead box K, isoform N; forkhead domain 68A; myocyte nuclear factor",
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        "protein_name": "Liprin-alpha, isoform E",
        "gene_name": "Liprin-alpha",
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        "refseq_name": "Liprin-alpha, isoform E",
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            {
                "id": "NP_001260155",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260155",
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        "gene_names_refseq": "CG11199; DLiprin-alpha; DLiprin; Dliprin-alpha; Dmel\\CG11199; LIP.1; LIP1; LIP; LPR; Liprin-alpha; Liprin; lip-alpha; liprin-alpha; liprin; lpr; oos",
        "protein_names_uniprotkb": "Liprin-alpha, isoform E",
        "protein_names_refseq": "CG11199-PE; LAR-interacting protein 1; Liprin-alpha, isoform E; Liprin-alpha-PE; dliprin-alpha; liprin-alpha; liprin; out of step",
        "tax_id": 7227,
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        "pathway": " (dme:Dmel_CG11199);  (R-DME-181429);  (R-DME-181430);  (R-DME-210500);  (R-DME-212676);  (R-DME-264642);  (R-DME-388844)",
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        "protein_names_uniprotkb": "5.6.1.3; CENP-meta, isoform C",
        "protein_names_refseq": "CENP-meta, isoform C; CG6392-PC; Cenp-meta; CenpMeta; Kinesin2A; cmet-PC",
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        "refseq_name": "secretory pathway calcium atpase, isoform G",
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            {
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        "protein_names_uniprotkb": "P-type Ca(2+) transporter; 7.2.2.10",
        "protein_names_refseq": "CG32451-PG; SPoCk-PG; secretory pathway calcium atpase, isoform G; secretory pathway calcium atpase",
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        ],
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        "length": 350,
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        ],
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        "protein_names_uniprotkb": "Aldo-keto reductase 1B; 1.1.1.21; 1.1.1.300; 1.1.1.372; 1.1.1.54; Aldose reductase; dAR1",
        "protein_names_refseq": "Akr1B-PA; Aldo-keto reductase 1B, isoform A; Aldo/keto reductase; CG6084-PA; aldehyde reductase; aldose reductase",
        "tax_id": 7227,
        "disease": "stomach cancer (Disease Ontology:DOID:10534); allergic disease (Disease Ontology:DOID:1205); arteriosclerosis (Disease Ontology:DOID:2349); hyperglycemia (Disease Ontology:DOID:4195); hypokalemia (Disease Ontology:DOID:4500); hepatocellular carcinoma (Disease Ontology:DOID:684); cataract (Disease Ontology:DOID:83); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); galactosemia (Disease Ontology:DOID:9870)",
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        "publication_id_list": "10731132;12537572;15952742;31350199;38283991",
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        "function": "Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins (By similarity). Through production of prostaglandin F2alpha may regulate the activity of non-muscle myosin II in an autocrine or paracrine fashion; influences border cell and nurse cell stiffness to facilitate border cell cluster migration (PubMed:38283991). Also regulates the cell surface localization of integrins in an autocrine or paracrine fashion; influences border cell adhesion to maintain border cell cluster morphology (PubMed:38283991). In hemocytes, probably contributes to production of sugar alcohols in the hemolymph, which act as alarmins involved in gut-fat body innate immunological communication (GFIC); leads to activation of the imd/Relish signaling pathway in the fat body (PubMed:31350199)., [UniProtKB, PubMed, PubMed, UniProtKB]",
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                "id": "1.1.1.372",
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                "id": "1.1.1.54",
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        ],
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        "go_cellular_component": "GO:0005615 extracellular space;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol",
        "go_biological_process": "GO:0006061 sorbitol biosynthetic process;GO:0046370 fructose biosynthetic process;GO:0019640 D-glucuronate catabolic process to D-xylulose 5-phosphate;GO:0046173 polyol biosynthetic process",
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    },
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        "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); Kleefstra syndrome 1 (Disease Ontology:DOID:0060352); Kleefstra syndrome (Disease Ontology:DOID:0080597); melanoma (Disease Ontology:DOID:1909); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung adenocarcinoma (Disease Ontology:DOID:3910); viral infectious disease (Disease Ontology:DOID:934); alopecia areata (Disease Ontology:DOID:986)",
        "pathway": " (dme:Dmel_CG2995);  (R-DME-2559582);  (R-DME-6804760);  (R-DME-8953750)",
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        "disease": "pontocerebellar hypoplasia type 2C (Disease Ontology:DOID:0060269)",
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        "disease": "spinal muscular atrophy (Disease Ontology:DOID:12377); lysosomal storage disease (Disease Ontology:DOID:3211); Tay-Sachs disease (Disease Ontology:DOID:3320); Sandhoff disease (Disease Ontology:DOID:3323)",
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        "protein_names_refseq": "CG31902-PB; Spn28Da-PB; serpin 28Da",
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        "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); coarctation of the aorta (Disease Ontology:DOID:0051054); stroke (Disease Ontology:DOID:0051061); chemical colitis (Disease Ontology:DOID:0060186); ileitis (Disease Ontology:DOID:0060189); atrial fibrillation (Disease Ontology:DOID:0060224); thrombosis (Disease Ontology:DOID:0060903); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); Nagashima-type palmoplantar keratosis (Disease Ontology:DOID:0070555); polycystic kidney disease (Disease Ontology:DOID:0080322); corticosteroid-binding globulin deficiency (Disease Ontology:DOID:0090030); osteonecrosis (Disease Ontology:DOID:10159); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); nephritis (Disease Ontology:DOID:10952); meconium aspiration syndrome (Disease Ontology:DOID:11049); hydronephrosis (Disease Ontology:DOID:11111); IgA vasculitis (Disease Ontology:DOID:11123); disseminated intravascular coagulation (Disease Ontology:DOID:11247); adult respiratory distress syndrome (Disease Ontology:DOID:11394); pulmonary edema (Disease Ontology:DOID:11396); sciatic neuropathy (Disease Ontology:DOID:11446); prediabetes syndrome (Disease Ontology:DOID:11716); nephrotic syndrome (Disease Ontology:DOID:1184); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); allergic disease (Disease Ontology:DOID:1205); otosclerosis (Disease Ontology:DOID:12185); primary biliary cholangitis (Disease Ontology:DOID:12236); alcoholic hepatitis (Disease Ontology:DOID:12351); dilated cardiomyopathy (Disease Ontology:DOID:12930); retinopathy of prematurity (Disease Ontology:DOID:13025); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); uveitis (Disease Ontology:DOID:13141); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372); sick sinus syndrome (Disease Ontology:DOID:13884); toxic shock syndrome (Disease Ontology:DOID:14115); Fabry disease (Disease Ontology:DOID:14499); cystic fibrosis (Disease Ontology:DOID:1485); diffuse scleroderma (Disease Ontology:DOID:1580); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); atherosclerosis (Disease Ontology:DOID:1936); hyperinsulinism (Disease Ontology:DOID:2018); transient cerebral ischemia (Disease Ontology:DOID:224); arteriosclerosis (Disease Ontology:DOID:2349); multiple sclerosis (Disease Ontology:DOID:2377); central retinal vein occlusion (Disease Ontology:DOID:2450); endometriosis (Disease Ontology:DOID:289); acute pancreatitis (Disease Ontology:DOID:2913); glomerulonephritis (Disease Ontology:DOID:2921); severe acute respiratory syndrome (Disease Ontology:DOID:2945); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); temporal lobe epilepsy (Disease Ontology:DOID:3328); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); antithrombin III deficiency (Disease Ontology:DOID:3755); pulmonary fibrosis (Disease Ontology:DOID:3770); lung adenocarcinoma (Disease Ontology:DOID:3910); liver disease (Disease Ontology:DOID:409); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); cerebrovascular disease (Disease Ontology:DOID:6713); osteoarthritis (Disease Ontology:DOID:8398); chronic myeloid leukemia (Disease Ontology:DOID:8552); vasculitis (Disease Ontology:DOID:865); intermediate coronary syndrome (Disease Ontology:DOID:8805); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675); mitral valve prolapse (Disease Ontology:DOID:988); obesity (Disease Ontology:DOID:9970)",
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        "go_cellular_component": "GO:0005615 extracellular space",
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            {
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            {
                "id": "NP_001036537",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036537",
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            }
        ],
        "gene_names_uniprotkb": "CR33632; CG33632; Dmel\\CG33632; Dmel_CG33632",
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        "protein_names_uniprotkb": "MD-2-related lipid-recognition domain-containing protein",
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        ],
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        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_001036762",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036762",
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            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG3339; CG3339; DHC5; Dmel_CG3339",
        "gene_names_refseq": "CG3339; DHC5; Dmel\\CG3339",
        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG3339-PC; uncharacterized protein",
        "tax_id": 7227,
        "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); primary ciliary dyskinesia 7 (Disease Ontology:DOID:0110605); primary ciliary dyskinesia 40 (Disease Ontology:DOID:0111853)",
        "pathway": " (dme:Dmel_CG3339)",
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        "go_cellular_component": "GO:0005874 microtubule;GO:0005930 axoneme;GO:0030286 dynein complex;GO:0036157 outer dynein arm;GO:0097729 9+2 motile cilium",
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                "id": "Q0KI25_DROME",
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        ],
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        "protein_name": "Endoplasmic reticulum aminopeptidase 2",
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        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform B",
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            {
                "id": "NP_001036747",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036747",
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        ],
        "gene_names_uniprotkb": "CG13825; Dmel\\CG4467; CG13825; CG4467; Dmel\\CG4467; Dmel_CG4467",
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        "protein_names_refseq": "CG4467-PB; uncharacterized protein, isoform B",
        "tax_id": 7227,
        "disease": "leiomyoma (Disease Ontology:DOID:127); severe pre-eclampsia (Disease Ontology:DOID:13129); breast cancer (Disease Ontology:DOID:1612); endometrial carcinoma (Disease Ontology:DOID:2871); cervix carcinoma (Disease Ontology:DOID:2893); renal cell carcinoma (Disease Ontology:DOID:4450); polyhydramnios (Disease Ontology:DOID:8488); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (dme:Dmel_CG4467);  (R-DME-983168);  (R-DME-983170)",
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                "id": "NP_001036710",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036710",
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        "gene_names_refseq": "CG11598; Dmel\\CG11598",
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        "disease": "lysosomal acid lipase deficiency (Disease Ontology:DOID:0080217); Wolman disease (Disease Ontology:DOID:14497)",
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        "go_molecular_function": "GO:0016298 lipase activity;GO:0004806 triacylglycerol lipase activity",
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        "go_biological_process": "GO:0007320 insemination;GO:0006629 lipid metabolic process;GO:0016042 lipid catabolic process;GO:0007618 mating",
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        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
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                "id": "NP_001036701",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036701",
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        "gene_names_refseq": "BcDNA:RE53107; CG12817; Dmel\\CG12817",
        "protein_names_uniprotkb": "EF-hand domain-containing protein",
        "protein_names_refseq": "CG12817-PB; uncharacterized protein",
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        "protein_names_refseq": "Apoltp-PC; CG15828-PC; apolipoprotein lipid transfer particle; lipid transfer particle",
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        "protein_names_refseq": "CG9433-PA; Xpd-PA; lethal (2) SH2137; xeroderma pigmentosum D ortholog; xeroderma pigmentosum D",
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        "disease": "xeroderma pigmentosum (Disease Ontology:DOID:0050427); myelodysplastic syndrome (Disease Ontology:DOID:0050908); autosomal recessive congenital ichthyosis (Disease Ontology:DOID:0060655); cerebrooculofacioskeletal syndrome 2 (Disease Ontology:DOID:0080912); xeroderma pigmentosum group D (Disease Ontology:DOID:0110845); photosensitive trichothiodystrophy 1 (Disease Ontology:DOID:0111873); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); asphyxia neonatorum (Disease Ontology:DOID:11088); acoustic neuroma (Disease Ontology:DOID:12689); Down syndrome (Disease Ontology:DOID:14250); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); ovary epithelial cancer (Disease Ontology:DOID:2152); photosensitive trichothiodystrophy (Disease Ontology:DOID:2960); Cockayne syndrome (Disease Ontology:DOID:2962); high grade glioma (Disease Ontology:DOID:3070); coronary artery disease (Disease Ontology:DOID:3393); skin disease (Disease Ontology:DOID:37); lung non-small cell carcinoma (Disease Ontology:DOID:3908); macular degeneration (Disease Ontology:DOID:4448); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); hepatocellular carcinoma (Disease Ontology:DOID:684); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); multiple myeloma (Disease Ontology:DOID:9538); oral mucosa leukoplakia (Disease Ontology:DOID:9655); senile cataract (Disease Ontology:DOID:9669); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)",
        "pathway": " (dme:Dmel_CG9433);  (R-DME-112382);  (R-DME-113418);  (R-DME-5696395);  (R-DME-5696400);  (R-DME-674695);  (R-DME-6781823);  (R-DME-6782135);  (R-DME-6782210);  (R-DME-6796648);  (R-DME-72086);  (R-DME-73772);  (R-DME-73776);  (R-DME-73779);  (R-DME-75953);  (R-DME-75955);  (R-DME-76042);  (R-DME-77075)",
        "pathway_count": 18,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
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        "reported_mutagensis": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "disease_count": 33,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "7.2.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-",
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            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
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            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "2.7.7.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6",
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            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
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            },
            {
                "id": "2.4.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-",
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            },
            {
                "id": "2.4.2.30",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30",
                "type": "external"
            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "3.6.4.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12",
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            {
                "id": "2.7.11.1",
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                "id": "5.6.2.4",
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                "id": "3.1.-.-",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3",
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                "id": "5.2.1.8",
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                "id": "3.1.11.-",
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            {
                "id": "2.1.1.56",
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            {
                "id": "3.-.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-",
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            {
                "id": "5.6.1.1",
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            {
                "id": "3.4.19.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12",
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            },
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
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            },
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                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
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                "id": "5.6.2.-",
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                "id": "3.4.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-",
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            }
        ],
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        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005675 transcription factor TFIIH holo complex;GO:0000439 transcription factor TFIIH core complex;GO:0005700 polytene chromosome",
        "go_biological_process": "GO:0006974 DNA damage response;GO:0009411 response to UV;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0007088 regulation of mitotic nuclear division",
        "synthesized_glycan_count": 0,
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        "record_id": "Q7KVP9-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
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        "uniprot_canonical_ac": "Q7PLB8-1",
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            {
                "id": "Q7PLB8_DROME",
                "url": "https://www.uniprot.org/uniprot/Q7PLB8",
                "type": "external"
            }
        ],
        "mass": 266851.0,
        "length": 2394,
        "protein_name": "Fatty acid synthase",
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        "organism": "Fruit fly",
        "refseq_name": "fatty acid synthase 3",
        "refseq_ac": [
            {
                "id": "NP_001015405",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015405",
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            }
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        "protein_names_uniprotkb": "Fatty acid synthase; 1.1.1.100; 1.3.1.39; 2.3.1.41; 2.3.1.85; 3.1.2.14",
        "protein_names_refseq": "CG17374-PC; FASN3-PC; fatty acid synthase 3; lethal (3) 80Ff; lethal 4B; lethal4B",
        "tax_id": 7227,
        "disease": "muscular disease (Disease Ontology:DOID:0080000); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); colorectal cancer (Disease Ontology:DOID:9256)",
        "pathway": " (dme:Dmel_CG17374)",
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        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain., [UniProtKB, UniProtKB]",
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        "predicted_n_glycosites": 0,
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            {
                "id": "1.1.1.100",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100",
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            },
            {
                "id": "1.3.1.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.39",
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            },
            {
                "id": "2.3.1.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.38",
                "type": "external"
            },
            {
                "id": "2.3.1.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.39",
                "type": "external"
            },
            {
                "id": "2.3.1.41",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41",
                "type": "external"
            },
            {
                "id": "2.3.1.85",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.85",
                "type": "external"
            },
            {
                "id": "3.1.2.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14",
                "type": "external"
            },
            {
                "id": "4.2.1.59",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.59",
                "type": "external"
            },
            {
                "id": "1.3.1.104",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.104",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0031177 phosphopantetheine binding;GO:0004312 fatty acid synthase activity;GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity;GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity;GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity",
        "go_cellular_component": "",
        "go_biological_process": "GO:0006633 fatty acid biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q7PLB8-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
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        "uniprot_id": [
            {
                "id": "Q7PLI0_DROME",
                "url": "https://www.uniprot.org/uniprot/Q7PLI0",
                "type": "external"
            }
        ],
        "mass": 86823.0,
        "length": 781,
        "protein_name": "P120 catenin",
        "gene_name": "p120ctn",
        "organism": "Fruit fly",
        "refseq_name": "p120 catenin",
        "refseq_ac": [
            {
                "id": "NP_001036444",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036444",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "p120ctn; CG17484; Dmel\\CG17484; Dmel_CG17484; Dp120[ctn]; Dp120ctn; P120-catenin; P120ctn; P120; dP120ctn; dp120ctn; p120[ctn]; p120",
        "gene_names_refseq": "CG17484; Dmel\\CG17484; Dp120[ctn]; Dp120ctn; P120-catenin; P120ctn; P120; dP120ctn; dp120ctn; p120[ctn]; p120ctn; p120",
        "protein_names_uniprotkb": "P120 catenin",
        "protein_names_refseq": "Adherens-junction-protein-p120; CG17484-PA; P120-Catenin; adherens junction protein p120; p120 catenin; p120catenin; p120ctn-PA",
        "tax_id": 7227,
        "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); autism spectrum disorder (Disease Ontology:DOID:0060041); blepharocheilodontic syndrome 2 (Disease Ontology:DOID:0080346); arrhythmogenic right ventricular dysplasia 9 (Disease Ontology:DOID:0110077); DiGeorge syndrome (Disease Ontology:DOID:11198); major depressive disorder (Disease Ontology:DOID:1470); anxiety disorder (Disease Ontology:DOID:2030); ectodermal dysplasia (Disease Ontology:DOID:2121); schizophrenia (Disease Ontology:DOID:5419); pulmonary hypertension (Disease Ontology:DOID:6432)",
        "pathway": " (dme:Dmel_CG17484);  (R-DME-351906);  (R-DME-5218920);  (R-DME-6798695);  (R-DME-6809371);  (R-DME-9764561);  (R-DME-9958825)",
        "pathway_count": 7,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0045296 cadherin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0005912 adherens junction",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0098609 cell-cell adhesion;GO:0060997 dendritic spine morphogenesis;GO:0034334 adherens junction maintenance;GO:0001745 compound eye morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q7PLI0-1",
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        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
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            {
                "id": "Q86BI5_DROME",
                "url": "https://www.uniprot.org/uniprot/Q86BI5",
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            }
        ],
        "mass": 13838.0,
        "length": 121,
        "protein_name": "Protein dpy-30 homolog",
        "gene_name": "CG13057",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_788513",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788513",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CG13057; CG33060; Dmel\\CG33060; Dmel_CG33060",
        "gene_names_refseq": "CG13057; CG33060; Dmel\\CG33060",
        "protein_names_uniprotkb": "Protein dpy-30 homolog",
        "protein_names_refseq": "CG33060-PB; uncharacterized protein",
        "tax_id": 7227,
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            {
                "id": "NP_733185",
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            {
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        ],
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        "go_biological_process": "GO:0008049 male courtship behavior;GO:0007165 signal transduction;GO:0034220 monoatomic ion transmembrane transport;GO:0007635 chemosensory behavior;GO:0050909 sensory perception of taste",
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        ],
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    },
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        ],
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        "refseq_name": "uncharacterized protein",
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                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_726308",
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            }
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    },
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        ],
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        "organism": "Fruit fly",
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            {
                "id": "NP_726121",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_726121",
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            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG13492; CG13492; Dmel_CG13492",
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        "protein_names_refseq": "CG13492-PD; uncharacterized protein",
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    },
    {
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        ],
        "mass": 54835.0,
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        "protein_name": "Putative inorganic phosphate cotransporter",
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        "refseq_name": "major facilitator superfamily transporter 1",
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            {
                "id": "NP_726254",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_726254",
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        ],
        "gene_names_uniprotkb": "MFS1; CG11682; CG30272; Dmel\\CG30272; Dmel_CG30272",
        "gene_names_refseq": "CG11682; CG30272; Dmel\\CG30272; MFS1",
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        "protein_names_refseq": "CG30272-PA; MFS1-PA; major facilitator superfamily transporter 1",
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        "function": "May be an inorganic phosphate cotransporter., [UniProtKB, UniProtKB]",
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        "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015293 symporter activity",
        "go_cellular_component": "GO:0016020 membrane",
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    },
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        ],
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            {
                "id": "NP_649642",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649642",
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        ],
        "gene_names_uniprotkb": "Dmel\\CG17917; CG17917; Dmel_CG17917",
        "gene_names_refseq": "CG17917; Dmel\\CG17917",
        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG17917-PA; uncharacterized protein",
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        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0070373 negative regulation of ERK1 and ERK2 cascade",
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        "hit_score": 1.2,
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        ],
        "mass": 79823.0,
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        "protein_name": "ATP-dependent DNA helicase II subunit 2",
        "gene_name": "Ku80",
        "organism": "Fruit fly",
        "refseq_name": "Ku80",
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            {
                "id": "NP_609767",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609767",
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            }
        ],
        "gene_names_uniprotkb": "Ku80; BG:DS09217.6; CG18801; DmKu80; Dmel\\CG18801; Dmel_CG18801; KU80; Ku; ku80",
        "gene_names_refseq": "BG:DS09217.6; CG18801; DmKu80; Dmel\\CG18801; KU80; Ku80; Ku; ku80",
        "protein_names_uniprotkb": "ATP-dependent DNA helicase II subunit 2; 3.6.4.12",
        "protein_names_refseq": "CG18801-PA; Ku80-PA; Ku80",
        "tax_id": 7227,
        "disease": "alcohol use disorder (Disease Ontology:DOID:1574); squamous cell carcinoma (Disease Ontology:DOID:1749); rectum cancer (Disease Ontology:DOID:1993); basal cell carcinoma (Disease Ontology:DOID:2513); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); multiple myeloma (Disease Ontology:DOID:9538)",
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        "class_list": "",
        "function": "Involved in non-homologous end joining (NHEJ) DNA double strand break repair., [UniProtKB, UniProtKB]",
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            {
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        "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome (Disease Ontology:DOID:0050997); colorectal carcinoma (Disease Ontology:DOID:0080199); isolated hyperchlorhidrosis (Disease Ontology:DOID:0111371); lung cancer (Disease Ontology:DOID:1324); colon adenocarcinoma (Disease Ontology:DOID:234); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); Lynch syndrome (Disease Ontology:DOID:3883); lung non-small cell carcinoma (Disease Ontology:DOID:3908); fibrolamellar carcinoma (Disease Ontology:DOID:5015); hepatocellular carcinoma (Disease Ontology:DOID:684)",
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        "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen",
        "go_biological_process": "GO:0016477 cell migration;GO:0007618 mating",
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    },
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                "id": "Q9VA77_DROME",
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        ],
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        "organism": "Fruit fly",
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            {
                "id": "NP_651792",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651792",
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            }
        ],
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        "protein_names_refseq": "CG15534-PA; sphingomyelin phosphodiesterase; uncharacterized protein",
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            }
        ],
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        "go_biological_process": "GO:0046513 ceramide biosynthetic process;GO:0006685 sphingomyelin catabolic process",
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    },
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            }
        ],
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        "refseq_name": "uncharacterized protein",
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            {
                "id": "NP_651681",
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            }
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        ],
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            {
                "id": "NP_651656",
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        ],
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        ],
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        "protein_names_uniprotkb": "Histone acetyltransferase; 2.3.1.48",
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        "disease": "breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); clear cell renal cell carcinoma (Disease Ontology:DOID:4467)",
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            {
                "id": "2.3.1.259",
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        ],
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        "protein_name": "peptidylprolyl isomerase",
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            {
                "id": "NP_733246",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_733246",
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            }
        ],
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        "protein_names_uniprotkb": "peptidylprolyl isomerase; 5.2.1.8",
        "protein_names_refseq": "CG1866-PA; Moca-cyp, isoform A; Moca-cyp-PA",
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            {
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        "go_biological_process": "GO:0006457 protein folding;GO:0000398 mRNA splicing, via spliceosome",
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        ],
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        "protein_name": "1.14.11.-; HSPB1 associated protein 1",
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        "organism": "Fruit fly",
        "refseq_name": "HSPB1 associated protein 1",
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                "id": "NP_651581",
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        ],
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        "protein_names_uniprotkb": "1.14.11.-; HSPB1 associated protein 1",
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        "function": "May play a role in cellular stress response., [UniProtKB, UniProtKB]",
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            {
                "id": "NP_610087",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610087",
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        ],
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        "length": 388,
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            {
                "id": "NP_610078",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610078",
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            }
        ],
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        "protein_names_refseq": "CG9272-PA; DNA glycosylase; Nth-like DNA glycosylase 1; Nthl1-PA",
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        "disease": "familial adenomatous polyposis 3 (Disease Ontology:DOID:0080411)",
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        "function": "Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines., [UniProtKB, HAMAP]",
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            {
                "id": "3.1.11.2",
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            },
            {
                "id": "3.1.-.-",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-",
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            }
        ],
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        "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion",
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                "url": "https://www.uniprot.org/uniprot/A1Z7I1",
                "type": "external"
            }
        ],
        "mass": 71227.0,
        "length": 620,
        "protein_name": "Sodium/calcium exchanger membrane region domain-containing protein",
        "gene_name": "Dmel\\CG14744",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform C",
        "refseq_ac": [
            {
                "id": "NP_001097232",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097232",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG14744; CG14744; Dmel_CG14744",
        "gene_names_refseq": "CG14744; Dmel\\CG14744",
        "protein_names_uniprotkb": "Sodium/calcium exchanger membrane region domain-containing protein",
        "protein_names_refseq": "CG14744-PC; uncharacterized protein, isoform C",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG14744)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0015297 antiporter activity;GO:0005432 calcium:sodium antiporter activity",
        "go_cellular_component": "GO:0016020 membrane;GO:0030061 mitochondrial crista",
        "go_biological_process": "GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0006812 monoatomic cation transport;GO:0051560 mitochondrial calcium ion homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "A1Z7I1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A1ZAW0-1",
        "uniprot_id": [
            {
                "id": "DCR2_DROME",
                "url": "https://www.uniprot.org/uniprot/A1ZAW0",
                "type": "external"
            }
        ],
        "mass": 197765.0,
        "length": 1722,
        "protein_name": "Endoribonuclease Dcr-2",
        "gene_name": "Dcr-2",
        "organism": "Fruit fly",
        "refseq_name": "Dicer-2, isoform A",
        "refseq_ac": [
            {
                "id": "NP_523778",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523778",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dcr-2; CG6493; DCR-2; DCR2; DICER-2; DICER; Dcr2; Dcr; Dicer-II; Dicer2; Dicer; DmDcr-2; Dmel\\CG6493; Dmel_CG6493; cg6493; dDcr2; dcr-2; dcr2; dcr; dic2; dicer-2; dicer2; dicer; dmDcr-2",
        "gene_names_refseq": "CG6493; DCR-2; DCR2; DICER-2; DICER; Dcr-2; Dcr2; Dcr; Dicer-II; Dicer2; Dicer; DmDcr-2; Dmel\\CG6493; cg6493; dDcr2; dcr-2; dcr2; dcr; dic2; dicer-2; dicer2; dicer; dmDcr-2",
        "protein_names_uniprotkb": "Endoribonuclease Dcr-2; 3.1.26.3; Protein Dicer-2",
        "protein_names_refseq": "CG6493-PA; Dcr-2-PA; Dicer-2, isoform A; Dicer2; dicer 2; dicer-2",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG6493)",
        "pathway_count": 1,
        "publication_count": 36,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;15066283;15550672;16110336;16554838;17569856;17569867;18953338;19635780;21245036;21419681;23063653;24009507;24488111;25589440;25891075;26109356;26109357;26257286;26601278;27872309;28416567;28874570;29040648;29269422;29317541;29550490;32843367;34257295;34590626;35768503;35768513",
        "class_list": "",
        "function": "Double-stranded RNA (dsRNA) endoribonuclease which cleaves endogenous (endo), exogenous (exo), and viral dsRNAs to produce short interfering RNAs (siRNAs) (PubMed:15066283, PubMed:16554838, PubMed:18953338, PubMed:19635780, PubMed:21419681, PubMed:23063653, PubMed:24009507, PubMed:24488111, PubMed:25891075, PubMed:27872309, PubMed:28416567, PubMed:28874570, PubMed:29040648, PubMed:29317541, PubMed:29550490, PubMed:32843367, PubMed:34257295, PubMed:34590626, PubMed:35768513). The generated siRNAs then mediate gene silencing, also called RNA interference (RNAi), by controlling the elimination of endogenous transcripts from mobile and repetitive DNA elements of the genome as well as exogenous RNA of viral origin (PubMed:15066283, PubMed:16554838, PubMed:18953338, PubMed:21419681, PubMed:23063653, PubMed:24009507, PubMed:24488111, PubMed:27872309, PubMed:28416567, PubMed:28874570, PubMed:29040648, PubMed:29317541, PubMed:29550490, PubMed:32843367, PubMed:34257295, PubMed:34590626, PubMed:35768513). Also acts in an RNAi-independent manner to activate translation through cytoplasmic polyadenylation (PubMed:29317541). As well as its role in dsRNA processing, essential in several steps of the siRNA biogenesis pathway, including siRNA loading into the Argonaute 2 (AGO2)-containing RNA-induced silencing complex (siRISC), length-dependent dicing and guide strand selection for target silencing by the siRISC (PubMed:15066283, PubMed:15550672, PubMed:21245036, PubMed:21419681, PubMed:26257286, PubMed:27872309, PubMed:28416567, PubMed:34590626, PubMed:35768503). Cleaves dsRNAs into siRNAs that are predominantly around twenty-one nucleotides in length (PubMed:15066283, PubMed:21419681, PubMed:23063653, PubMed:24488111, PubMed:27872309, PubMed:28416567, PubMed:28874570, PubMed:29269422, PubMed:29550490, PubMed:32843367, PubMed:34257295, PubMed:35768513). Displays a preference for binding and processing blunt termini (BLT), likely non-self dsRNAs, over dsRNAs with 2 nucleotides 3' overhanging (3'ovr) termini, which are typically the structure of endogenous dsRNAs (PubMed:25891075, PubMed:29269422, PubMed:29550490, PubMed:32843367, PubMed:34257295, PubMed:34590626). According to many reports, the cleavage reaction mode of the enzyme changes according to the termini of the dsRNA substrate (PubMed:21419681, PubMed:25891075, PubMed:28416567, PubMed:29269422, PubMed:32843367, PubMed:34590626). BLT dsRNAs undergo an ATP-dependent processive reaction whereby multiple siRNAs of heterogeneous sizes are produced before the enzyme dissociates (PubMed:21419681, PubMed:25891075, PubMed:28416567, PubMed:29269422, PubMed:29550490, PubMed:32843367, PubMed:34590626). In contrast, dsRNAs with 3'ovr termini, which are typically the structure of endogenous dsRNAs, undergo ATP-independent, distributive cleavage whereby the enzyme dissociates after each cleavage to produce siRNAs of around 22 nucleotides (PubMed:25891075, PubMed:29269422, PubMed:32843367, PubMed:34590626). However, according to another report, the mode of cleavage reaction is not affected by the terminal structures of the dsRNAs substrates (PubMed:34257295). This report suggests that the enzyme is able to initiate processive cleavage of both BLT and 3'ovr dsRNA substrates, and only rarely initiates distributive cleavage (PubMed:34257295). During dsRNA processing and AGO2-loading, requires association with dsRNA-binding accessory proteins loqs isoform PD (loqs-PD) and r2d2 (PubMed:15550672, PubMed:21245036, PubMed:24009507, PubMed:28416567, PubMed:28874570, PubMed:29040648, PubMed:29550490). Functions with r2d2 to form the siRNA-mediated RISC loading complex (siRLC) which is responsible for Ago2-loading of endo- and exo-siRNAs (PubMed:15550672, PubMed:21245036, PubMed:28416567, PubMed:35768503). Interaction with loqs-PD increases initial binding to dsRNA substrates and promotes processing of a subset of endo- and exo-dsRNAs (PubMed:21245036, PubMed:24009507, PubMed:28874570, PubMed:29040648, PubMed:29550490, PubMed:34257295). In the absence of r2d2, may also form an alternative siRLC with loqs-PD to load siRNAs into the siRISC (PubMed:21245036). Function with loqs-PD allows the dicer enzyme to cleave endogenous dsRNA templates independently of their termini, and is required for ATP-dependent processing of a subset of siRNAs but is not required for antiviral RNAi (PubMed:24009507, PubMed:25891075, PubMed:29269422, PubMed:29550490, PubMed:32843367, PubMed:34590626). This suggests that the enzyme's intrinsic termini preferences function in viral defense, while function with loqs-PD allows processing of endogenous dsRNAs with diverse termini (PubMed:29269422, PubMed:32843367). However, according to another report the mode of cleavage reaction is not affected by the presence or absence of loqs-PD (PubMed:34257295). Loaded siRNAs serve as a guide to direct the siRISC to complementary RNAs to degrade them or prevent their translation (PubMed:15066283). The siRLC plays an important role in the ATP-dependent asymmetry sensing of the duplex, and is therefore also responsible for the selection of the strand that ultimately acts as the guide siRNA for the siRISC (PubMed:29040648, PubMed:35768503). Thermodynamically asymmetric siRNAs are preoriented in the siRLC by either the dsRNA-binding r2d2 protein, or the loqs-PD protein in the alternative siRLC, which preferentially bind to the most thermodynamically stable strand prior to loading onto AGO2 (PubMed:15550672, PubMed:29040648, PubMed:35768503). Both r2d2 and Dcr-2 also initiate unwinding of the siRNA duplex, at which point the heterodimer is exchanged by AGO2 (PubMed:15550672). The strand that was bound by r2d2 is discarded while the one that was bound by Dcr-2 is loaded onto Ago2 and serves as guide to direct the siRISC to complementary RNAs to degrade them or prevent their translation (PubMed:15550672). Independently of its role in RNAi, acts with the cytoplasmic poly(A) polymerase wisp to promote cytoplasmic polyadenylation and translational activation of certain messenger RNAs including r2d2 and toll (Tl) transcripts (PubMed:26601278, PubMed:29317541). Consequently it is involved in the post-transcriptional regulation of the Toll immune signaling pathway and promoting resistance to fungal and viral infections (PubMed:26601278, PubMed:29317541). As an RNA-binding protein, likely functions in cytoplasmic polyadenylation by recruiting the poly(A) RNA polymerase wisp to target mRNAs (PubMed:26601278, PubMed:29317541)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 22,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q95YG3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003730 mRNA 3'-UTR binding;GO:0035197 siRNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0016442 RISC complex",
        "go_biological_process": "GO:0070922 RISC complex assembly;GO:0007626 locomotory behavior;GO:0051607 defense response to virus;GO:0002230 positive regulation of defense response to virus by host;GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "A1ZAW0-1",
        "record_type": "protein",
        "filter_code": "0000000.0100101.010000.000000100000000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0A126GUN8-1",
        "uniprot_id": [
            {
                "id": "A0A126GUN8_DROME",
                "url": "https://www.uniprot.org/uniprot/A0A126GUN8",
                "type": "external"
            }
        ],
        "mass": 83489.0,
        "length": 760,
        "protein_name": "Kinesin-like protein",
        "gene_name": "Klp54D",
        "organism": "Fruit fly",
        "refseq_name": "Kinesin-like protein at 54D, isoform E",
        "refseq_ac": [
            {
                "id": "NP_001303355",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303355",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Klp54D; CG15844; CG43323; DmKlp54D; Dmel\\CG43323; Dmel_CG43323; KIF 12; KIF12; KLP1; KLP54D; Klp1",
        "gene_names_refseq": "CG15844; CG43323; DmKlp54D; Dmel\\CG43323; KIF 12; KIF12; KLP1; KLP54D; Klp1; Klp54D",
        "protein_names_uniprotkb": "Kinesin-like protein",
        "protein_names_refseq": "CG43323-PE; Kinesin-like protein 54D; Kinesin-like protein at 54D, isoform E; Kinesin4A; Klp54D-PE",
        "tax_id": 7227,
        "disease": "progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547)",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "",
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        "mined_c_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0003777 microtubule motor activity;GO:0016887 ATP hydrolysis activity",
        "go_cellular_component": "GO:0005874 microtubule;GO:0005737 cytoplasm;GO:0005871 kinesin complex",
        "go_biological_process": "GO:0007018 microtubule-based movement",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "A0A126GUN8-1",
        "record_type": "protein",
        "filter_code": "0000000.0000110.100000.000000100000000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0A0B4K6N2-1",
        "uniprot_id": [
            {
                "id": "A0A0B4K6N2_DROME",
                "url": "https://www.uniprot.org/uniprot/A0A0B4K6N2",
                "type": "external"
            }
        ],
        "mass": 59473.0,
        "length": 520,
        "protein_name": "Forkhead box P, isoform C",
        "gene_name": "FoxP",
        "organism": "Fruit fly",
        "refseq_name": "forkhead box P, isoform C",
        "refseq_ac": [
            {
                "id": "NP_001247011",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247011",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FoxP; CG16899; CG32937; CG43067; DmFoxP; Dmcg16899; Dmel\\CG43067; Dmel_CG43067; dFoxP; fd85E",
        "gene_names_refseq": "CG16899; CG32937; CG43067; DmFoxP; Dmcg16899; Dmel\\CG43067; FoxP; dFoxP; fd85E",
        "protein_names_uniprotkb": "Forkhead box P, isoform C",
        "protein_names_refseq": "CG43067-PC; FoxP-PC; forkhead box P, isoform C; forkhead box P; forkhead domain 85E",
        "tax_id": 7227,
        "disease": "Korean hemorrhagic fever (Disease Ontology:DOID:0050200); adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); specific developmental disorder (Disease Ontology:DOID:0060038); autism spectrum disorder (Disease Ontology:DOID:0060041); graft-versus-host disease (Disease Ontology:DOID:0081267); immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome (Disease Ontology:DOID:0090110); complex cortical dysplasia with other brain malformations (Disease Ontology:DOID:0090131); speech-language disorder-1 (Disease Ontology:DOID:0111275); intellectual disability-severe speech delay-mild dysmorphism syndrome (Disease Ontology:DOID:0111331); pleural tuberculosis (Disease Ontology:DOID:106); hypertension (Disease Ontology:DOID:10763); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Human papillomavirus infectious disease (Disease Ontology:DOID:11166); anogenital venereal wart (Disease Ontology:DOID:11168); chlamydia (Disease Ontology:DOID:11263); primary biliary cholangitis (Disease Ontology:DOID:12236); malaria (Disease Ontology:DOID:12365); trichostrongyloidiasis (Disease Ontology:DOID:1255); autistic disorder (Disease Ontology:DOID:12849); Huntington's disease (Disease Ontology:DOID:12858); hypothyroidism (Disease Ontology:DOID:1459); major depressive disorder (Disease Ontology:DOID:1470); congenital heart disease (Disease Ontology:DOID:1682); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); Epstein-Barr virus infectious disease (Disease Ontology:DOID:2938); pulmonary tuberculosis (Disease Ontology:DOID:2957); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); multidrug-resistant tuberculosis (Disease Ontology:DOID:401); syphilis (Disease Ontology:DOID:4166); articulation disorder (Disease Ontology:DOID:4186); dyslexia (Disease Ontology:DOID:4428); esophagus adenocarcinoma (Disease Ontology:DOID:4914); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); schizophrenia (Disease Ontology:DOID:5419); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); peritonitis (Disease Ontology:DOID:8283); infectious mononucleosis (Disease Ontology:DOID:8568); cutaneous leishmaniasis (Disease Ontology:DOID:9111); Wiskott-Aldrich syndrome (Disease Ontology:DOID:9169); Barrett's esophagus (Disease Ontology:DOID:9206); colorectal cancer (Disease Ontology:DOID:9256); language disorder (Disease Ontology:DOID:93); type 1 diabetes mellitus (Disease Ontology:DOID:9744); hypoplastic left heart syndrome (Disease Ontology:DOID:9955)",
        "pathway": " (dme:Dmel_CG43067);  (R-DME-8877330)",
        "pathway_count": 2,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "total_n_glycosites": 0,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
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        "disease_count": 52,
        "glyco_site_count": 0,
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        "ec_number_list": [],
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            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "2.7.11.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25",
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            },
            {
                "id": "2.7.11.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12",
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            },
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.11.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0042594 response to starvation;GO:0055088 lipid homeostasis;GO:0008286 insulin receptor signaling pathway;GO:0035331 negative regulation of hippo signaling",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "A1ZBC4-1",
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        "filter_code": "0000000.0000101.010000.000000100000000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
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            {
                "id": "Q9W233_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9W233",
                "type": "external"
            }
        ],
        "mass": 89190.0,
        "length": 813,
        "protein_name": "Fibronectin type-III domain-containing protein",
        "gene_name": "Idit",
        "organism": "Fruit fly",
        "refseq_name": "",
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        "gene_names_uniprotkb": "Idit; 33143; CG13509; CG33143; CG4232; Dmel\\CG33143; Dmel_CG33143; mdcds_16487",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Fibronectin type-III domain-containing protein",
        "protein_names_refseq": "",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG33143)",
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        "go_biological_process": "GO:0016239 positive regulation of macroautophagy",
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                "id": "A1Z782_DROME",
                "url": "https://www.uniprot.org/uniprot/A1Z782",
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        ],
        "mass": 71722.0,
        "length": 646,
        "protein_name": "PX domain-containing protein kinase-like protein",
        "gene_name": "Dmel\\CG8726",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform B",
        "refseq_ac": [
            {
                "id": "NP_610341",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610341",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG8726; CG8726; Dmel_CG8726",
        "gene_names_refseq": "CG8726; Dmel\\CG8726",
        "protein_names_uniprotkb": "PX domain-containing protein kinase-like protein; Modulator of Na,K-ATPase",
        "protein_names_refseq": "CG8726-PB; uncharacterized protein, isoform B",
        "tax_id": 7227,
        "disease": "polycythemia due to hypoxia (Disease Ontology:DOID:2835)",
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        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
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        "go_molecular_function": "GO:0003779 actin binding;GO:0005524 ATP binding;GO:0035091 phosphatidylinositol binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane",
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    {
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            {
                "id": "SPOUT_DROME",
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        ],
        "mass": 53881.0,
        "length": 485,
        "protein_name": "28S rRNA (uridine-N(3))-methyltransferase",
        "gene_name": "ptch",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform A",
        "refseq_ac": [
            {
                "id": "NP_610543",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610543",
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            }
        ],
        "gene_names_uniprotkb": "ptch; CG12128; Dmel\\CG12128; Dmel_CG12128",
        "gene_names_refseq": "CG12128; Dmel\\CG12128",
        "protein_names_uniprotkb": "28S rRNA (uridine-N(3))-methyltransferase; 2.1.1.-",
        "protein_names_refseq": "CG12128-PA; uncharacterized protein, isoform A",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG12128)",
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        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;39671501",
        "class_list": "",
        "function": "S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the uridine in position 3485 of 28S rRNA., [UniProtKB, PubMed]",
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            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
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            }
        ],
        "go_molecular_function": "GO:0070042 rRNA (uridine-N3-)-methyltransferase activity;GO:0008173 RNA methyltransferase activity;GO:1904047 S-adenosyl-L-methionine binding",
        "go_cellular_component": "GO:0005730 nucleolus",
        "go_biological_process": "GO:0070475 rRNA base methylation",
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        "record_id": "A1Z830-1",
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            {
                "id": "SCHNR_DROME",
                "url": "https://www.uniprot.org/uniprot/A1Z8F4",
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            }
        ],
        "mass": 276829.0,
        "length": 2577,
        "protein_name": "Protein schnurri",
        "gene_name": "shn",
        "organism": "Fruit fly",
        "refseq_name": "schnurri, isoform E",
        "refseq_ac": [
            {
                "id": "NP_001260882",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260882",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "shn; CG7734; quo",
        "gene_names_refseq": "BEST:SD06302; CG7734; Dmel\\CG7734; EP(2)2359; EP2359; SD06302; SHN; Schnurri; Shn; l(2)04738; quo; shn",
        "protein_names_uniprotkb": "Protein schnurri",
        "protein_names_refseq": "CG7734-PE; quo vadis; schnurri, isoform E; schnurri; shn-PE; umnitza",
        "tax_id": 7227,
        "disease": "juvenile polyposis syndrome (Disease Ontology:DOID:0050787); autosomal dominant intellectual developmental disorder 43 (Disease Ontology:DOID:0070073); intellectual disability (Disease Ontology:DOID:1059); Alzheimer's disease (Disease Ontology:DOID:10652); asthma (Disease Ontology:DOID:2841); schizophrenia (Disease Ontology:DOID:5419)",
        "pathway": " (dme:Dmel_CG7734)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "10731132;11071761;11071762;11290303;12537572;12705870;15296719;16109720;22275438;25307481;38344065;7588072;7774017;7774018;9334286",
        "class_list": "",
        "function": "Transcription cofactor involved in dpp/BMP TGF-beta signal-induced transcriptional regulation downstream of the receptor serine/threonine kinases tkv/thickvein and put/punt (PubMed:11071761, PubMed:11071762, PubMed:11290303, PubMed:15296719, PubMed:7774017, PubMed:7774018). Recruited to DNA enhancer elements by association with the SMAD protein Mad-Med complex (PubMed:15296719, PubMed:16109720). Mad-Med acts as a transcriptional activator but recruits shn/shnurri to enhance its activity or switch to transcriptional repression (PubMed:11071761, PubMed:16109720). When recruited by Mad-Med can regulate dpp-responsive genes by directly activating their expression or by repressing expression of the transcriptional repressor brk/brinker (PubMed:11290303, PubMed:12705870, PubMed:15296719, PubMed:16109720). Also involved in repression of other key developmental genes including bam and gsb (PubMed:15296719). Required for dpp-signaling induced repression of brk and induction of sna during embryonic development (PubMed:11290303). Required for transcriptional regulation of dpp-responsive genes in the mesoderm and endoderm during embryonic gut development; required for the proper differentiation of dorsal ectodermal cells (PubMed:11071761, PubMed:7774017, PubMed:7774018). Not required for early embryo development (PubMed:11290303). Required for expression of dpp-responsive genes involved in patterning of the wing imaginal disc (PubMed:11071762). Required for dpp-responsive cell proliferation and anterior-posterior patterning in the wing (PubMed:11071762). Required for vein formation in the developing wing (PubMed:11071762, PubMed:38344065, PubMed:7588072, PubMed:7774018). Required in somatic cyst cells of the testes for regulation of germ cell proliferation (PubMed:9334286). Prevents JNK-induced apoptosis during embryogenesis by repressing expression of the pro-apoptotic protein rpr/reaper; required for survival of dorsal edge cells during dorsal closure (PubMed:25307481). Required for tissue maintenance after DNA damage, probably by inducing expression of the growth factor Pvf1, which stimulates the macrophage-like activity of hemocytes (PubMed:22275438)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
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        "secondary_ac_list": "A0A0B4KFC0;D3DMC9;Q0E9C5;Q24107;Q24605",
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        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding",
        "go_cellular_component": "GO:0005634 nucleus",
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        "synthesized_glycan_count": 0,
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    },
    {
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                "url": "https://www.uniprot.org/uniprot/Q9W2Z7",
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        ],
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        "protein_name": "Cell wall protein DAN4",
        "gene_name": "CG12634; CG12649; CG18512; Dmel\\CG32694",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform B",
        "refseq_ac": [
            {
                "id": "NP_727383",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_727383",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CG12634; CG12649; CG18512; Dmel\\CG32694; BcDNA:RE02049; CG12634; CG12649; CG18512; CG32694; Dmel\\CG32694; Dmel_CG32694",
        "gene_names_refseq": "BcDNA:RE02049; CG12634; CG12649; CG18512; CG32694; Dmel\\CG32694",
        "protein_names_uniprotkb": "Cell wall protein DAN4",
        "protein_names_refseq": "CG32694-PB; uncharacterized protein, isoform B",
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        ],
        "mass": 146536.0,
        "length": 1320,
        "protein_name": "Multidrug resistance protein homolog 65",
        "gene_name": "AMT; Dmel\\CG10226",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform A",
        "refseq_ac": [
            {
                "id": "NP_648040",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648040",
                "type": "external"
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        ],
        "gene_names_uniprotkb": "AMT; Dmel\\CG10226; AMT; CG10226; DmCG10226; Dmel\\CG10226; Dmel_CG10226",
        "gene_names_refseq": "AMT; CG10226; DmCG10226; Dmel\\CG10226",
        "protein_names_uniprotkb": "Multidrug resistance protein homolog 65",
        "protein_names_refseq": "ABC multidrug transporter; CG10226-PA; uncharacterized protein, isoform A",
        "tax_id": 7227,
        "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); familial temporal lobe epilepsy 3 (Disease Ontology:DOID:0060750); progressive familial intrahepatic cholestasis 3 (Disease Ontology:DOID:0070223); intrahepatic cholestasis of pregnancy 3 (Disease Ontology:DOID:0070229); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); nasal type extranodal NK/T-cell lymphoma (Disease Ontology:DOID:0080797); inflammatory bowel disease 13 (Disease Ontology:DOID:0110893); osteonecrosis (Disease Ontology:DOID:10159); antisocial personality disorder (Disease Ontology:DOID:10939); familial hyperlipidemia (Disease Ontology:DOID:1168); primary biliary cholangitis (Disease Ontology:DOID:12236); malaria (Disease Ontology:DOID:12365); Behcet's disease (Disease Ontology:DOID:13241); hepatic encephalopathy (Disease Ontology:DOID:13413); cholestasis (Disease Ontology:DOID:13580); cystic fibrosis (Disease Ontology:DOID:1485); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); cannabis dependence (Disease Ontology:DOID:1849); intrahepatic cholestasis (Disease Ontology:DOID:1852); cholecystitis (Disease Ontology:DOID:1949); nephroblastoma (Disease Ontology:DOID:2154); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); cryoglobulinemia (Disease Ontology:DOID:2917); pulmonary tuberculosis (Disease Ontology:DOID:2957); familial Mediterranean fever (Disease Ontology:DOID:2987); invasive ductal carcinoma (Disease Ontology:DOID:3008); high grade glioma (Disease Ontology:DOID:3070); temporal lobe epilepsy (Disease Ontology:DOID:3328); toxic encephalopathy (Disease Ontology:DOID:3602); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); allergic rhinitis (Disease Ontology:DOID:4481); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); chronic myeloid leukemia (Disease Ontology:DOID:8552); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976)",
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        "publication_count": 11,
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        "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0008559 ABC-type xenobiotic transporter activity",
        "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0043190 ATP-binding cassette (ABC) transporter complex",
        "go_biological_process": "GO:0009636 response to toxic substance;GO:0097254 renal tubular secretion;GO:0055085 transmembrane transport;GO:0042908 xenobiotic transport",
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            {
                "id": "X2JE74_DROME",
                "url": "https://www.uniprot.org/uniprot/X2JE74",
                "type": "external"
            }
        ],
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        "length": 1170,
        "protein_name": "X11L, isoform F",
        "gene_name": "X11L",
        "organism": "Fruit fly",
        "refseq_name": "X11L, isoform F",
        "refseq_ac": [
            {
                "id": "NP_001285376",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285376",
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            }
        ],
        "gene_names_uniprotkb": "X11L; CG5675; CG5678; Dmel\\CG5675; Dmel_CG5675; Dmint1; Dmint; MINT; Mint; X11-like; X11Lalpha; X11; dX11Lalpha; dX11L; dX11; x11Lalpha",
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        "protein_names_uniprotkb": "X11L, isoform F",
        "protein_names_refseq": "CG5675-PF; X11-like; X11/Mint; X11L, isoform F; X11L-PF; dX11/Mint/Lin-10",
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        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0043197 dendritic spine",
        "go_biological_process": "GO:0048749 compound eye development;GO:0072657 protein localization to membrane;GO:0007268 chemical synaptic transmission",
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                "id": "Q9VW79_DROME",
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        "gene_name": "Dmel\\CG14187",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform A",
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            {
                "id": "NP_649177",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649177",
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        ],
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        "gene_names_refseq": "CG14187; Dmel\\CG14187",
        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG14187-PA; uncharacterized protein, isoform A",
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        "go_cellular_component": "GO:0042600 egg chorion",
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            {
                "id": "A0A0B4KI34_DROME",
                "url": "https://www.uniprot.org/uniprot/A0A0B4KI34",
                "type": "external"
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        ],
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        "protein_name": "CIN85 and CD2AP related, isoform J",
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        "organism": "Fruit fly",
        "refseq_name": "CIN85 and CD2AP related, isoform J",
        "refseq_ac": [
            {
                "id": "NP_001263129",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263129",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "cindr; BcDNA:GH03163; CD2AP; CG11316; CG1408; CG31012; Cindir; Cindr; Dmel\\CG31012; Dmel_CG31012",
        "gene_names_refseq": "BcDNA:GH03163; CD2AP; CG11316; CG1408; CG31012; Cindir; Cindr; Dmel\\CG31012; cindr",
        "protein_names_uniprotkb": "CIN85 and CD2AP related, isoform J",
        "protein_names_refseq": "CD2AP and CIN85 orthologue; CG31012-PJ; CIN85 and CD2AP orthologue; CIN85 and CD2AP related, isoform J; cindr-PJ",
        "tax_id": 7227,
        "disease": "immunodeficiency 61 (Disease Ontology:DOID:0111999); focal segmental glomerulosclerosis 3 (Disease Ontology:DOID:0112245); nephrotic syndrome (Disease Ontology:DOID:1184); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); tauopathy (Disease Ontology:DOID:680); end stage renal disease (Disease Ontology:DOID:783)",
        "pathway": " (dme:Dmel_CG31012);  (R-DME-182971);  (R-DME-8856825);  (R-DME-8856828)",
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        "gene_names_refseq": "CG11693; Dmel\\CG11693",
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        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0008190 eukaryotic initiation factor 4E binding;GO:0000340 RNA 7-methylguanosine cap binding;GO:0003743 translation initiation factor activity;GO:0003729 mRNA binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0016281 eukaryotic translation initiation factor 4F complex",
        "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006417 regulation of translation;GO:0006413 translational initiation;GO:0006412 translation",
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            {
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                "type": "external"
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        ],
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        "protein_name": "Widerborst, isoform H",
        "gene_name": "wdb",
        "organism": "Fruit fly",
        "refseq_name": "widerborst, isoform H",
        "refseq_ac": [
            {
                "id": "NP_001368946",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001368946",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "wdb; 07; B56-2; BEST:LD02456; BcDNA:LD34343; CG5643; Dmel\\CG5643; Dmel_CG5643; EP3559; LD02456; PP2-AB; PP2A-B'; PP2A[B'-2]; PP2A; PP2a; WDB; Wdb; Widerborst; dB56-2; dPP2A-B56-2; dPP2A; l(3)S031807; wbd",
        "gene_names_refseq": "0318/07; B56-2; BEST:LD02456; BcDNA:LD34343; CG5643; Dmel\\CG5643; EP3559; LD02456; PP2-AB; PP2A-B'; PP2A[B'-2]; PP2A; PP2a; WDB; Wdb; Widerborst; dB56-2; dPP2A-B56-2; dPP2A; l(3)S031807; wbd; wdb",
        "protein_names_uniprotkb": "Widerborst, isoform H",
        "protein_names_refseq": "CG5643-PH; PP2A B subunit; PP2A regulatory subunit; protein phosphatase 2a; protein phosphatase PP2A; wdb-PH; widerborst, isoform H; widerborst; wiederborst",
        "tax_id": 7227,
        "disease": "cancer (Disease Ontology:DOID:162); transient cerebral ischemia (Disease Ontology:DOID:224)",
        "pathway": " (dme:Dmel_CG5643);  (R-DME-195253);  (R-DME-196299);  (R-DME-389513);  (R-DME-432620);  (R-DME-432626);  (R-DME-5673000);  (R-DME-5675221);  (R-DME-6811558);  (R-DME-9833482)",
        "pathway_count": 10,
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        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;14980226;16110336;16139204;16543224;16603629;17569856;17569867;17575052;18593878;25589440;26109356;26109357",
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        "go_molecular_function": "GO:0019888 protein phosphatase regulator activity;GO:0072542 protein phosphatase activator activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000159 protein phosphatase type 2A complex;GO:0005634 nucleus;GO:0005829 cytosol",
        "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0010888 negative regulation of lipid storage;GO:0007059 chromosome segregation;GO:0007165 signal transduction",
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            {
                "id": "ERC_DROME",
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        ],
        "mass": 255301.0,
        "length": 2238,
        "protein_name": "Protein bruchpilot",
        "gene_name": "brp",
        "organism": "Fruit fly",
        "refseq_name": "bruchpilot, isoform G",
        "refseq_ac": [
            {
                "id": "NP_001097241",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097241",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "brp; BRP; Brp; Bruchpilot; CG12932; CG12933; CG1931; CG30336; CG30337; CG34146; CG42344; Cast; Dmel\\CG42344; Dmel_CG42344; MAbnc82; Mabnc82; NC82; Nc82; mAb nc82; mAbnc82; nc-82; nc82",
        "gene_names_refseq": "BRP; Brp; Bruchpilot; CG12932; CG12933; CG1931; CG30336; CG30337; CG34146; CG42344; Cast; Dmel\\CG42344; MAbnc82; Mabnc82; NC82; Nc82; brp; mAb nc82; mAbnc82; nc-82; nc82",
        "protein_names_uniprotkb": "Protein bruchpilot; CAZ-associated structural protein; Cytomatrix at the active zone associated structural protein; Cytoskeletal matrix associated with the active zone-associated structural protein; ELKS-CAST-ERC homolog",
        "protein_names_refseq": "CG42344-PG; brp-PG; bruchpilot, isoform G; bruchpilot; brunchpilot; burchpilot; monoclonal antibody nc82",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG42344)",
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        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;16543132;16614170;17569856;17569867;19596851;19771148;19851455;20980589;21368057;22153374;23960145;25130366;25589440;26109356;26109357;30745339;30782781;36095217;40245499",
        "class_list": "",
        "function": "Structural component of the presynaptic active zone cytomatrix (T-bar) electron-dense structures involved in assembly, structural integrity, organization and function of presynaptic active zones (PubMed:16543132, PubMed:16614170, PubMed:19596851, PubMed:23960145, PubMed:25130366). Acts as a tether, binding and maintaining a supply of readily releasable synaptic vesicles within the presynaptic active zone in proximity to clusters of Ca(2+) channels; facilitates the coupling of synaptic vesicle release to the activity of the Ca(2+) channels (PubMed:16614170, PubMed:20980589, PubMed:23960145, PubMed:25130366, PubMed:30782781). Functions downstream of Lipirin-alpha during active zone assembly (PubMed:19596851). Involved in maintenance of Ca(2+) channel clustering during active zone maturation (PubMed:16614170, PubMed:19596851). Involved in the activity of dopaminergic neurons (DAn), including the MP1 DAn that innervates the heel of the mushroom body, and is involved in active forgetting (PubMed:36095217). Involved in olfactory memory (PubMed:21368057)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Structural component of the presynaptic active zone cytomatrix (T-bar) electron-dense structures; each active zone cytomatrix is composed of both long 190 kDa and short 170 kDa isoforms arranged in a circular array of alternating clusters., [UniProtKB, PubMed, PubMed]",
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        "go_molecular_function": "GO:0098882 structural constituent of presynaptic active zone",
        "go_cellular_component": "GO:0098831 presynaptic active zone cytoplasmic component;GO:0031594 neuromuscular junction;GO:0043679 axon terminus;GO:0048786 presynaptic active zone;GO:0008021 synaptic vesicle",
        "go_biological_process": "GO:0048789 cytoskeletal matrix organization at active zone;GO:0097091 synaptic vesicle clustering;GO:0048790 maintenance of presynaptic active zone structure;GO:1990709 presynaptic active zone organization;GO:0007274 neuromuscular synaptic transmission",
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        "protein_name": "Rad, Gem/Kir family member 1, isoform B",
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        "organism": "Fruit fly",
        "refseq_name": "Rad, Gem/Kir family member 1, isoform B",
        "refseq_ac": [
            {
                "id": "NP_725875",
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        "gene_names_uniprotkb": "Rgk1; CG30127; CG44011; CG9811; CT27512; Dmel\\CG44011; Dmel_CG44011; RGK1; rgk1",
        "gene_names_refseq": "CG30127; CG44011; CG9811; CT27512; Dmel\\CG44011; RGK1; Rgk1; rgk1",
        "protein_names_uniprotkb": "Rad, Gem/Kir family member 1, isoform B",
        "protein_names_refseq": "CG44011-PB; Rad, Gem/Kir family member 1, isoform B; Rgk1-PB",
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        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009898 cytoplasmic side of plasma membrane;GO:0098793 presynapse",
        "go_biological_process": "GO:0007264 small GTPase-mediated signal transduction;GO:0007615 anesthesia-resistant memory;GO:0072375 medium-term memory",
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                "id": "A0A0B4LHY5_DROME",
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        ],
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        "length": 728,
        "protein_name": "Lnk, isoform D",
        "gene_name": "Lnk",
        "organism": "Fruit fly",
        "refseq_name": "Lnk, isoform D",
        "refseq_ac": [
            {
                "id": "NP_001287536",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287536",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Lnk; CG 17367; CG17367; CG5908; Dmel\\CG17367; Dmel_CG17367; LNK; SH2B; dSH2B; lnk",
        "gene_names_refseq": "CG 17367; CG17367; CG5908; Dmel\\CG17367; LNK; Lnk; SH2B; dSH2B; lnk",
        "protein_names_uniprotkb": "Lnk, isoform D",
        "protein_names_refseq": "CG17367-PD; Lnk, isoform D; Lnk-PD",
        "tax_id": 7227,
        "disease": "chromosome 16p11.2 deletion syndrome, 220-kb (Disease Ontology:DOID:0060398); familial erythrocytosis 1 (Disease Ontology:DOID:0060652); colorectal carcinoma (Disease Ontology:DOID:0080199); essential thrombocythemia (Disease Ontology:DOID:2224); myelofibrosis (Disease Ontology:DOID:4971); chronic myeloid leukemia (Disease Ontology:DOID:8552); colorectal cancer (Disease Ontology:DOID:9256); type 1 diabetes mellitus (Disease Ontology:DOID:9744)",
        "pathway": " (dme:Dmel_CG17367);  (R-DME-983231)",
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        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005938 cell cortex",
        "go_biological_process": "GO:0060180 female mating behavior;GO:0007165 signal transduction;GO:0040008 regulation of growth;GO:1904263 positive regulation of TORC1 signaling;GO:0033500 carbohydrate homeostasis",
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        ],
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        "protein_name": "Prothoracicotropic hormone, isoform F",
        "gene_name": "Ptth",
        "organism": "Fruit fly",
        "refseq_name": "prothoracicotropic hormone, isoform F",
        "refseq_ac": [
            {
                "id": "NP_001285550",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285550",
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            }
        ],
        "gene_names_uniprotkb": "Ptth; CG13687; Dmel\\CG13687; Dmel_CG13687; PTTH; ptth",
        "gene_names_refseq": "CG13687; Dmel\\CG13687; PTTH; Ptth; ptth",
        "protein_names_uniprotkb": "Prothoracicotropic hormone, isoform F",
        "protein_names_refseq": "CG13687-PF; Ptth-PF; prothoracicotopic hormone; prothoracicotropic hormone, isoform F; prothoracicotropic hormone",
        "tax_id": 7227,
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        "go_molecular_function": "GO:0018445 prothoracicotrophic hormone activity",
        "go_cellular_component": "GO:0043196 varicosity",
        "go_biological_process": "GO:0046957 negative phototaxis;GO:0007552 metamorphosis;GO:0008293 torso signaling pathway;GO:0045998 positive regulation of ecdysteroid biosynthetic process",
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        "protein_name": "long-chain-fatty-acid--CoA ligase",
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        "organism": "Fruit fly",
        "refseq_name": "Acyl-CoA synthetase long-chain, isoform J",
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            {
                "id": "NP_001260810",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260810",
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            }
        ],
        "gene_names_uniprotkb": "Acsl; 4; 7447; ACSL1; ACSL3; ACS; CG8732; Dmel\\CG8732; Dmel_CG8732; FACS; FCS; acsl; anon-WO0172774.173; dAcsl; dFAC; l(2)05847; l(2)44DEa; l(2)7447; l(2)SH0465; l(2)SH2 0465; l(2)k05304",
        "gene_names_refseq": "7447; ACSL1; ACSL3/4; ACSL3; ACS; Acsl; CG8732; Dmel\\CG8732; FACS; FCS; acsl; anon-WO0172774.173; dAcsl; dFAC; l(2)05847; l(2)44DEa; l(2)7447; l(2)SH0465; l(2)SH2 0465; l(2)k05304",
        "protein_names_uniprotkb": "long-chain-fatty-acid--CoA ligase; 6.2.1.3",
        "protein_names_refseq": "Acsl-PJ; Acyl-CoA synthetase long-chain, isoform J; Acyl-CoAsynthetase long-chain; CG8732-PJ; Long-chain acyl-CoA synthetase; fatty acyl CoA synthetase; fatty acyl coenzyme A (CoA) synthetase; fatty acyl-CoA synthetase; lethal (2) 44DEa; lethal (2) SH0465",
        "tax_id": 7227,
        "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); non-syndromic X-linked intellectual disability 63 (Disease Ontology:DOID:0112050); prostate cancer (Disease Ontology:DOID:10283); intellectual disability (Disease Ontology:DOID:1059); lung cancer (Disease Ontology:DOID:1324); Sjogren-Larsson syndrome (Disease Ontology:DOID:14501); breast cancer (Disease Ontology:DOID:1612); asthma (Disease Ontology:DOID:2841)",
        "pathway": " (dme:Dmel_CG8732);  (R-DME-434313);  (R-DME-75876)",
        "pathway_count": 3,
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        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
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            {
                "id": "6.2.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3",
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        ],
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        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0030424 axon;GO:0045202 synapse;GO:0005741 mitochondrial outer membrane",
        "go_biological_process": "GO:0007399 nervous system development;GO:0007268 chemical synaptic transmission;GO:0035282 segmentation;GO:0010890 positive regulation of triglyceride storage;GO:0007411 axon guidance",
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    },
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                "id": "A1ZBW0_DROME",
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        ],
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        "length": 502,
        "protein_name": "Heterogeneous nuclear ribonucleoprotein K, isoform C",
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        "organism": "Fruit fly",
        "refseq_name": "heterogeneous nuclear ribonucleoprotein K, isoform C",
        "refseq_ac": [
            {
                "id": "NP_995906",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_995906",
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        ],
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        "gene_names_refseq": "BL; Bancal; Bl; CG13425; Dmel\\CG13425; HnRNP-K; Hrb57A; Q18; bl; dhnRNP K; hnRNP K; hnRNP-A1L; hrb57a; l(2)k08305",
        "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein K, isoform C",
        "protein_names_refseq": "CG13425-PC; HnRNP-K-PC; bancal hnRNP; bancal; heterogeneous nuclear ribonucleoprotein K, isoform C; heterogeneous nuclear ribonucleoprotein at 57A",
        "tax_id": 7227,
        "disease": "prostate cancer (Disease Ontology:DOID:10283); Raynaud disease (Disease Ontology:DOID:10300); colorectal cancer (Disease Ontology:DOID:9256)",
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        "protein_name": "Bleomycin hydrolase",
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        ],
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        "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006508 proteolysis;GO:0009636 response to toxic substance;GO:0043418 homocysteine catabolic process",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
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            },
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                "id": "3.1.-.-",
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            }
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        "gene_names_refseq": "CG10626; DLKR; Dmel\\CG10626; LK-R; LKR; LkR; Lkr; anon-WO0131005.17; anon-WO0170980.118; anon-WO0170980.119; dLKR; lkr",
        "protein_names_uniprotkb": "Leucokinin receptor",
        "protein_names_refseq": "CG10626-PA; Lkr-PA; drosokinin receptor; kinin receptor; leucokinin R; leucokinin receptor",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG10626)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "",
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        "missing_score": 10000,
        "biomarker_type": "",
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        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008188 neuropeptide receptor activity;GO:0004983 neuropeptide Y receptor activity;GO:0042071 leucokinin receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane",
        "go_biological_process": "GO:2000252 negative regulation of feeding behavior;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9VRM0-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VRP4-1",
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            {
                "id": "Q9VRP4_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VRP4",
                "type": "external"
            }
        ],
        "mass": 57641.0,
        "length": 518,
        "protein_name": "Bifunctional coenzyme A synthase",
        "gene_name": "Ppat-Dpck",
        "organism": "Fruit fly",
        "refseq_name": "bifunctional phosphopantetheine adenylyltransferase - Dephospho-CoA kinase",
        "refseq_ac": [
            {
                "id": "NP_647985",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647985",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Ppat-Dpck; CG10575; Dmel\\CG10575; Dmel_CG10575; PPAT-DPCK; PPAT; dCOASY; dPPAT-DPCK",
        "gene_names_refseq": "CG10575; DPCK/PPAT; Dmel\\CG10575; PPAT-DPCK; Ppat-Dpck; dCOASY; dPPAT-DPCK",
        "protein_names_uniprotkb": "Bifunctional coenzyme A synthase; 2.7.1.24; 2.7.7.3",
        "protein_names_refseq": "4'-phosphopantetheine adenylyltransferase - dephospho-CoA kinase; CG10575-PA; Ppat-Dpck-PA; bifunctional phosphopantetheine adenylyltransferase - Dephospho-CoA kinase",
        "tax_id": 7227,
        "disease": "neurodegeneration with brain iron accumulation 6 (Disease Ontology:DOID:0110740); pontocerebellar hypoplasia type 12 (Disease Ontology:DOID:0112327); mucopolysaccharidosis III (Disease Ontology:DOID:12801); cancer (Disease Ontology:DOID:162)",
        "pathway": " (dme:Dmel_CG10575)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "Bifunctional enzyme that catalyzes the fourth step of the coenzyme A biosynthetic pathway, the adenylation of 4'-phosphopantetheine, and the fifth step, the phosphorylation of dephospho-CoA to CoA., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
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        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "2.7.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.24",
                "type": "external"
            },
            {
                "id": "2.7.7.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.3",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004140 dephospho-CoA kinase activity;GO:0004595 pantetheine-phosphate adenylyltransferase activity;GO:0005524 ATP binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0070328 triglyceride homeostasis;GO:0015937 coenzyme A biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9VRP4-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VRT4-1",
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            {
                "id": "Q9VRT4_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VRT4",
                "type": "external"
            }
        ],
        "mass": 73186.0,
        "length": 662,
        "protein_name": "Major facilitator superfamily (MFS) profile domain-containing protein",
        "gene_name": "CG6596",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_648019",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648019",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CG6596; CG42269; CG6600; Dmel\\CG42269; Dmel_CG42269",
        "gene_names_refseq": "CG42269; CG6596; CG6600; Dmel\\CG42269",
        "protein_names_uniprotkb": "Major facilitator superfamily (MFS) profile domain-containing protein",
        "protein_names_refseq": "CG42269-PE; uncharacterized protein",
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        "disease": "extrahepatic cholestasis (Disease Ontology:DOID:13619); intrahepatic cholestasis (Disease Ontology:DOID:1852); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021)",
        "pathway": " (dme:Dmel_CG42269);  (R-DME-112311);  (R-DME-181430);  (R-DME-196807);  (R-DME-200425);  (R-DME-2161517);  (R-DME-442660);  (R-DME-549127);  (R-DME-561048);  (R-DME-917937);  (R-DME-9749641);  (R-DME-9793528)",
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        "go_molecular_function": "GO:0022857 transmembrane transporter activity",
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            {
                "id": "Q9VS65_DROME",
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            }
        ],
        "mass": 39884.0,
        "length": 344,
        "protein_name": "Peptidase M14 domain-containing protein",
        "gene_name": "CG18415",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_729252",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_729252",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CG18415; CG32379; Dmel\\CG32379; Dmel_CG32379",
        "gene_names_refseq": "CG18415; CG32379; Dmel\\CG32379",
        "protein_names_uniprotkb": "Peptidase M14 domain-containing protein",
        "protein_names_refseq": "CG32379-PB; uncharacterized protein",
        "tax_id": 7227,
        "disease": "familial temporal lobe epilepsy 5 (Disease Ontology:DOID:0060752); familial febrile seizures 11 (Disease Ontology:DOID:0111308); nephrotic syndrome (Disease Ontology:DOID:1184); Behcet's disease (Disease Ontology:DOID:13241); thrombocytosis (Disease Ontology:DOID:2228); pancreatitis (Disease Ontology:DOID:4989); chronic kidney disease (Disease Ontology:DOID:784); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (dme:Dmel_CG32379);  (R-DME-2022377)",
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        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity",
        "go_cellular_component": "GO:0005615 extracellular space",
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    },
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                "id": "Q9VS81_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VS81",
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        ],
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        "protein_name": "Uncharacterized protein",
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        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_648131",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648131",
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            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG7548; CG7548; Dmel_CG7548",
        "gene_names_refseq": "CG7548; Dmel\\CG7548",
        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG7548-PA; uncharacterized protein",
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            }
        ],
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        "protein_names_refseq": "CG7716-PA; t-Grip84-PA; testis-specific gamma-tubulin ring protein 84",
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        "go_molecular_function": "GO:0043015 gamma-tubulin binding",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005814 centriole",
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        "go_cellular_component": "GO:0005634 nucleus",
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        "refseq_name": "imaginal discs arrested",
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            {
                "id": "NP_647837",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647837",
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            }
        ],
        "gene_names_uniprotkb": "ida; APC5; Apc5; CG10850; Dmel\\CG10850; Dmel_CG10850; IDA; Ida; l(3)63Fb; l(3)SH7",
        "gene_names_refseq": "APC5; Apc5; CG10850; Dmel\\CG10850; IDA; Ida; ida; l(3)63Fb; l(3)SH7",
        "protein_names_uniprotkb": "Anaphase-promoting complex subunit 5; Cyclosome subunit 5",
        "protein_names_refseq": "CG10850-PA; ida-PA; imaginal discs arrested",
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        "disease": "",
        "pathway": " (dme:Dmel_CG10850);  (R-DME-141430);  (R-DME-174048);  (R-DME-174084);  (R-DME-174154);  (R-DME-174178);  (R-DME-174184);  (R-DME-176407);  (R-DME-176408);  (R-DME-176409);  (R-DME-176412);  (R-DME-179409);  (R-DME-2467813);  (R-DME-2559582);  (R-DME-68867);  (R-DME-69017);  (R-DME-983168)",
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        "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins., [UniProtKB, UniProtKB]",
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        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005680 anaphase-promoting complex",
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        ],
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        "refseq_name": "carnitine palmitoyltransferase 2",
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            {
                "id": "NP_647756",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647756",
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        "protein_names_refseq": "CG2107-PA; CPT2-PA; carnitine palmitoyltransferase 2",
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        "disease": "muscular disease (Disease Ontology:DOID:0080000); lipid metabolism disorder (Disease Ontology:DOID:3146); brain disease (Disease Ontology:DOID:936)",
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        ],
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        "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0008527 taste receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body",
        "go_biological_process": "GO:0007165 signal transduction;GO:0034220 monoatomic ion transmembrane transport",
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    },
    {
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            {
                "id": "Q9W1W2_DROME",
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            }
        ],
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        "gene_name": "CG9895",
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            {
                "id": "NP_611747",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611747",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CG9895; CG34209; CG42741; Dmel\\CG42741; Dmel_CG42741",
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        "go_cellular_component": "GO:0005634 nucleus",
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    },
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            {
                "id": "NP_611712",
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            }
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            {
                "id": "Q9W212_DROME",
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        ],
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        "protein_name": "Dynein regulatory complex subunit 2",
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        "refseq_name": "uncharacterized protein",
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            {
                "id": "NP_611708",
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            }
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        "protein_names_uniprotkb": "Dynein regulatory complex subunit 2; Coiled-coil domain-containing protein 65",
        "protein_names_refseq": "CG30259-PA; uncharacterized protein",
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        "disease": "primary ciliary dyskinesia 27 (Disease Ontology:DOID:0110611)",
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        "function": "Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules., [UniProtKB, UniProtKB]",
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        ],
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        ],
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            {
                "id": "NP_611642",
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        "protein_names_uniprotkb": "Golgi matrix protein 130 kD",
        "protein_names_refseq": "CG11061-PA; GM130-PA; dGM130; golgi matrix protein 130 kD ortholog; golgi matrix protein 130 kD",
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        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane;GO:0005795 Golgi stack;GO:0005801 cis-Golgi network",
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                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611617",
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        "gene_names_refseq": "CG13493; Comr; Dmel\\CG13493; Z2-1340; comr; zab",
        "protein_names_uniprotkb": "Cookie monster",
        "protein_names_refseq": "CG13493-PA; comr-PA; cookie monster; zuker-aly-like b",
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        "disease": "disease by infectious agent (Disease Ontology:DOID:0050117); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); corticosteroid-binding globulin deficiency (Disease Ontology:DOID:0090030); osteogenesis imperfecta type 6 (Disease Ontology:DOID:0110350); heparin cofactor II deficiency (Disease Ontology:DOID:0111901); retinitis pigmentosa (Disease Ontology:DOID:10584); Alzheimer's disease (Disease Ontology:DOID:10652); kidney failure (Disease Ontology:DOID:1074); anogenital venereal wart (Disease Ontology:DOID:11168); corneal neovascularization (Disease Ontology:DOID:11382); sciatic neuropathy (Disease Ontology:DOID:11446); leukostasis (Disease Ontology:DOID:12986); uveitis (Disease Ontology:DOID:13141); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); venous tributary occlusion of retina (Disease Ontology:DOID:13514); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); toxic shock syndrome (Disease Ontology:DOID:14115); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); retinal vein occlusion (Disease Ontology:DOID:1727); nephroblastoma (Disease Ontology:DOID:2154); transient cerebral ischemia (Disease Ontology:DOID:224); endometriosis (Disease Ontology:DOID:289); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); osteosarcoma (Disease Ontology:DOID:3347); lung non-small cell carcinoma (Disease Ontology:DOID:3908); macular degeneration (Disease Ontology:DOID:4448); macular retinal edema (Disease Ontology:DOID:4449); brain edema (Disease Ontology:DOID:4724); melioidosis (Disease Ontology:DOID:5052); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425); hepatocellular carcinoma (Disease Ontology:DOID:684); retinoblastoma (Disease Ontology:DOID:768); hyperthyroidism (Disease Ontology:DOID:7998); retinal degeneration (Disease Ontology:DOID:8466); chronic fatigue syndrome (Disease Ontology:DOID:8544); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (dme:Dmel_CG43366);  (R-DME-114608);  (R-DME-1650814);  (R-DME-381426);  (R-DME-6798695);  (R-DME-8939242);  (R-DME-8957275);  (R-DME-9855719);  (R-DME-9948001)",
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        "go_molecular_function": "GO:0030414 peptidase inhibitor activity",
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        "kg_view_protein": true
    },
    {
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            {
                "id": "A1Z6J2_DROME",
                "url": "https://www.uniprot.org/uniprot/A1Z6J2",
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            }
        ],
        "mass": 142495.0,
        "length": 1276,
        "protein_name": "Sterol regulatory element-binding protein cleavage-activating protein",
        "gene_name": "SCAP",
        "organism": "Fruit fly",
        "refseq_name": "SREBP cleavage activating protein",
        "refseq_ac": [
            {
                "id": "NP_788277",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788277",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SCAP; CG14592; CG33131; CG8356; Dmel\\CG33131; Dmel_CG33131; Scap_Dm; Scap; dSCAP; dScap; dscap",
        "gene_names_refseq": "CG14592; CG33131; CG8356; Dmel\\CG33131; SCAP; Scap_Dm; Scap; dSCAP; dScap; dscap",
        "protein_names_uniprotkb": "Sterol regulatory element-binding protein cleavage-activating protein",
        "protein_names_refseq": "CG33131-PA; SCAP-PA; SREBP cleavage activating protein",
        "tax_id": 7227,
        "disease": "end stage renal disease (Disease Ontology:DOID:783)",
        "pathway": " (dme:Dmel_CG33131);  (R-DME-1655829)",
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        "publication_count": 11,
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        "class_list": "",
        "function": "Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain., [UniProtKB, UniProtKB]",
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        "go_molecular_function": "GO:0032934 sterol binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012507 ER to Golgi transport vesicle membrane;GO:0032936 SREBP-SCAP complex",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006631 fatty acid metabolic process;GO:0008203 cholesterol metabolic process;GO:0045540 regulation of cholesterol biosynthetic process;GO:0032933 SREBP signaling pathway",
        "synthesized_glycan_count": 0,
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    },
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        ],
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        "protein_name": "Uncharacterized protein",
        "gene_name": "Dmel\\CG15909",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
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            {
                "id": "NP_610225",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610225",
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            }
        ],
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        "protein_names_refseq": "CG15909-PA; uncharacterized protein",
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        ],
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        "protein_name": "Zinc/iron regulated transporter-related protein 42C.2",
        "gene_name": "Zip42C.2",
        "organism": "Fruit fly",
        "refseq_name": "Zinc/iron regulated transporter-related protein 42C.2",
        "refseq_ac": [
            {
                "id": "NP_610231",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610231",
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        ],
        "gene_names_uniprotkb": "Zip42C.2; CG9430; Dmel\\CG9430; Dmel_CG9430; ZIP42C.2; cg9430; dZIP2; dZIP42C.2; dZip2; dZip42C.2",
        "gene_names_refseq": "CG9430; Dmel\\CG9430; ZIP42C.2; Zip42C.2; cg9430; dZIP2; dZIP42C.2; dZip2; dZip42C.2",
        "protein_names_uniprotkb": "Zinc/iron regulated transporter-related protein 42C.2",
        "protein_names_refseq": "CG9430-PB; Zinc/iron regulated transporter-related protein 42C.2; Zip42C.2-PB",
        "tax_id": 7227,
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        ],
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        "protein_name": "Tetraspanin 42Ek, isoform A; Tetraspanin 42Ek, isoform B",
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    },
    {
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            {
                "id": "A1Z759_DROME",
                "url": "https://www.uniprot.org/uniprot/A1Z759",
                "type": "external"
            }
        ],
        "mass": 46057.0,
        "length": 412,
        "protein_name": "TsaA-like domain-containing protein",
        "gene_name": "CG12822-PA",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform A",
        "refseq_ac": [
            {
                "id": "NP_610327",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610327",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CG12822-PA; CG12822; Dmel\\CG12822; Dmel_CG12822",
        "gene_names_refseq": "CG12822-PA; CG12822; Dmel\\CG12822",
        "protein_names_uniprotkb": "TsaA-like domain-containing protein",
        "protein_names_refseq": "CG12822-PA; uncharacterized protein, isoform A",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG12822)",
        "pathway_count": 1,
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        "go_molecular_function": "GO:0089715 tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity",
        "go_cellular_component": "",
        "go_biological_process": "GO:0030488 tRNA methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
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    },
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            {
                "id": "A1Z7D1_DROME",
                "url": "https://www.uniprot.org/uniprot/A1Z7D1",
                "type": "external"
            }
        ],
        "mass": 44162.0,
        "length": 398,
        "protein_name": "Uncharacterized protein",
        "gene_name": "CG2280",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_724665",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724665",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CG2280; CG30375; Dmel\\CG30375; Dmel_CG30375; SP80b; SP80",
        "gene_names_refseq": "CG2280; CG30375; Dmel\\CG30375; SP80b; SP80",
        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG30375-PA; uncharacterized protein",
        "tax_id": 7227,
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        "pathway": " (dme:Dmel_CG30375)",
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        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0006508 proteolysis;GO:0050832 defense response to fungus;GO:0035008 positive regulation of melanization defense response;GO:0160032 Toll receptor ligand protein activation cascade",
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    },
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            {
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            }
        ],
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        "length": 469,
        "protein_name": "Spacewatch, isoform A; Spacewatch, isoform B",
        "gene_name": "spaw",
        "organism": "Fruit fly",
        "refseq_name": "spacewatch, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001286195",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286195",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "spaw; BcDNA:AT04457; CG2149; CG30365; Dmel\\CG30365; Dmel_CG30365",
        "gene_names_refseq": "BcDNA:AT04457; CG2149; CG30365; Dmel\\CG30365; spaw",
        "protein_names_uniprotkb": "Spacewatch, isoform A; Spacewatch, isoform B",
        "protein_names_refseq": "CG30365-PB; spacewatch, isoform B; spaw-PB",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG30365)",
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        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
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        "uniprot_canonical_ac": "A1Z7L8-1",
        "uniprot_id": [
            {
                "id": "TGFR1_DROME",
                "url": "https://www.uniprot.org/uniprot/A1Z7L8",
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        ],
        "mass": 69316.0,
        "length": 622,
        "protein_name": "Receptor protein serine/threonine kinase babo",
        "gene_name": "babo",
        "organism": "Fruit fly",
        "refseq_name": "baboon, isoform C",
        "refseq_ac": [
            {
                "id": "NP_001163092",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163092",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "babo; Atr-1; Atr-I; CG8224",
        "gene_names_refseq": "ATR-1; ATR-I; Atf1; Atr-1; Atr-I; Atr45A; AtrI; BABO; BaboA; Baboon; Babo; Bab; CG8224; Dmel\\CG8224; Gprk-3; Gprk3; STK-E; atr-I; babo; l(2)44Fd; l(2)k16912",
        "protein_names_uniprotkb": "Receptor protein serine/threonine kinase babo; 2.7.11.30; Protein baboon",
        "protein_names_refseq": "CG8224-PC; G protein-coupled receptor kinase 3; activin A receptor 45A; activin type I receptor; babo-PC; baboa; baboon, isoform C; baboon",
        "tax_id": 7227,
        "disease": "Loeys-Dietz syndrome (Disease Ontology:DOID:0050466); Loeys-Dietz syndrome 1 (Disease Ontology:DOID:0070235); stomach cancer (Disease Ontology:DOID:10534); urinary bladder cancer (Disease Ontology:DOID:11054); leiomyoma (Disease Ontology:DOID:127); malignant mesothelioma (Disease Ontology:DOID:1790); pancreatic cancer (Disease Ontology:DOID:1793); osteochondrodysplasia (Disease Ontology:DOID:2256); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); Lynch syndrome (Disease Ontology:DOID:3883); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); lung small cell carcinoma (Disease Ontology:DOID:5409); kidney disease (Disease Ontology:DOID:557); Ferguson-Smith tumor (Disease Ontology:DOID:5585); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); osteoarthritis (Disease Ontology:DOID:8398); retinal degeneration (Disease Ontology:DOID:8466); colorectal cancer (Disease Ontology:DOID:9256)",
        "pathway": " (dme:Dmel_CG8224);  (R-DME-1502540);  (R-DME-2173788);  (R-DME-2173789);  (R-DME-2173791);  (R-DME-5689880);  (R-DME-9839389)",
        "pathway_count": 7,
        "publication_count": 15,
        "publication_id_list": "10320478;10731132;12537572;12581521;16437159;16951053;17119022;18171686;18820452;19766717;22563507;32198477;38913612;8289834;9887103",
        "class_list": "",
        "function": "Essential for signaling by daw leading to activation of the canonical TGF-beta pathway and phosphorylation of Smox/SMAD2 (Probable) (PubMed:19766717). Important for larval development (PubMed:38913612)., [UniProtKB, PubMed, PubMed]; Type I transmembrane receptor serine/threonine kinase involved in the activin-like TGF-beta signaling pathway (PubMed:10320478, PubMed:17119022, PubMed:18820452, PubMed:8289834). Forms a receptor complex with a type II transmembrane receptor serine/threonine kinase, and upon activation by an activin/TGF-beta-like ligand phosphorylates downstream receptor-regulated SMAD (R-SMAD) transcription factors, inducing their nuclear localization resulting in regulation of activin/TGF-beta-responsive genes (PubMed:10320478, PubMed:17119022, PubMed:18820452, PubMed:8289834). When part of a heteromeric complex with the type I receptor put/punt can be activated by the activin/TGF-beta-like ligands Actbeta/activin, daw/dawdle and possibly myo/myoglianin; ligand specificity is probably isoform-dependent (PubMed:17119022, PubMed:18820452, PubMed:8289834). Upon activation phosphorylates the R-SMAD Smox/SMAD2 to activate the canonical TGF-beta pathway (PubMed:10320478, PubMed:17119022, PubMed:18820452, PubMed:19766717, PubMed:9887103). Can also phosphorylate Mad, the R-SMAD of the dpp BMP-like signaling pathway, in response to daw signaling but to a lesser extent (PubMed:18820452, PubMed:22563507). Phosphorylation of Mad is competitively regulated by Smox/SMAD2 (PubMed:22563507). Positive regulator of cell proliferation, probably through activation of the SMAD2-dependent activin signaling pathway (PubMed:9887103). Required for normal proliferation of medulla neuroblasts and laminar precursor cells in the optic lobe (PubMed:18171686). Involved in regulation of the ecdysteroid hormone receptor EcR in neuronal cells throughout the central nervous system (PubMed:38913612). Involved in axonal and dendritic pruning and neural remodeling of mushroom body gamma neurons during metamorphosis through regulation of EcR (PubMed:12581521). Involved in differentiation of dorsal cluster and ellipsoid body adult-specific neurons prior to metamorphosis (PubMed:16437159). Required in motoneurons for axon guidance or outgrowth of ISNb and SNa axons (PubMed:17119022). Involved in regulation of wing growth (PubMed:18820452). Signaling by daw or myo is involved in lifespan determination through regulation of proteasome-mediated degradation of misfolded or damaged proteins (PubMed:29615416)., [UniProtKB]; When in complex with put/punt can be activated by the activin-like TGF-beta ligands Actbeta or daw (PubMed:17119022, PubMed:18820452, PubMed:8289834). May be the main isoform involved in myo/myoglianin signaling to activate the canonical TGF-beta signaling pathway (Probable). This isoform is not essential for signaling by daw but may contribute; requires Isoform C (PubMed:19766717). Involved in regulation of the ecdysteroid hormone receptor EcR in neuronal cells throughout the central nervous system (PubMed:38913612). Important for regulation of larval brain growth, including proliferation and conversion of neuroepithelial cells (PubMed:38913612)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; When in complex with put/punt can be activated by the activin-like TGF-beta ligands Actbeta or daw but may be the main isoform involved in Actbeta signaling (PubMed:17119022, PubMed:18820452, PubMed:8289834). This isoform is not essential for signaling by daw but may contribute; requires Isoform C (PubMed:19766717). Not required for brain growth during larval development (PubMed:38913612). Required for optic lobe development and photoreceptor axon targeting; regulates proliferation of precursor cells in the optic lobe (PubMed:18171686). Required for viability (PubMed:18171686)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 4,
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        "secondary_ac_list": "A1Z7L9;Q7YU60",
        "ec_number_list": [
            {
                "id": "2.7.11.30",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "5.2.1.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "2.3.2.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016361 activin receptor activity, type I;GO:0048185 activin binding;GO:0017002 activin receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0048179 activin receptor complex",
        "go_biological_process": "GO:0007399 nervous system development;GO:0050803 regulation of synapse structure or activity;GO:0071363 cellular response to growth factor stimulus;GO:0010507 negative regulation of autophagy;GO:0009411 response to UV",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
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        "record_type": "protein",
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        "kg_view_protein": true
    },
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            {
                "id": "A1Z7R9_DROME",
                "url": "https://www.uniprot.org/uniprot/A1Z7R9",
                "type": "external"
            }
        ],
        "mass": 19781.0,
        "length": 180,
        "protein_name": "C3H1-type domain-containing protein",
        "gene_name": "Dmel\\CG42382",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_523665",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523665",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG42382; CG42382; CG8016; Dmel_CG42382",
        "gene_names_refseq": "CG42382; CG8016; Dmel\\CG42382",
        "protein_names_uniprotkb": "C3H1-type domain-containing protein",
        "protein_names_refseq": "CG42382-PA; uncharacterized protein",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG42382)",
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    },
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        ],
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        "protein_name": "Pneumococcal serine-rich repeat protein",
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            {
                "id": "NP_001097239",
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            }
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            {
                "id": "A1Z892_DROME",
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        ],
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        "protein_name": "1-Cys peroxiredoxin",
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        "refseq_name": "peroxiredoxin 6b",
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            {
                "id": "NP_724931",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724931",
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            }
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        "gene_names_uniprotkb": "Prx6b; BEST:LD11278; CG12405; DPx-2540-1; DPx2540; Dmel\\CG12405; Dmel_CG12405; Prx2540-1; Prx2540; dPRDX6-2; dPrx6a",
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        "protein_names_uniprotkb": "1-Cys peroxiredoxin",
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        "class_list": "",
        "function": "Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides., [UniProtKB, UniProtKB]",
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        ],
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        "protein_name": "Chromatin assembly factor 1, p105 subunit",
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            {
                "id": "NP_610589",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610589",
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            }
        ],
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        "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); prostate cancer (Disease Ontology:DOID:10283); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); skin melanoma (Disease Ontology:DOID:8923)",
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            {
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        ],
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        "protein_name": "Transporter",
        "gene_name": "Dmel\\CG8850",
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        "refseq_name": "uncharacterized protein, isoform B",
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            {
                "id": "NP_725122",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_725122",
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            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG8850; CG8850; DmNAT4; Dmel_CG8850",
        "gene_names_refseq": "CG8850; DmNAT4; Dmel\\CG8850",
        "protein_names_uniprotkb": "Transporter",
        "protein_names_refseq": "CG8850-PB; uncharacterized protein, isoform B",
        "tax_id": 7227,
        "disease": "cerebral creatine deficiency syndrome 1 (Disease Ontology:DOID:0050800)",
        "pathway": " (dme:Dmel_CG8850);  (R-DME-352230);  (R-DME-442660)",
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        "class_list": "",
        "function": "Unusual broad substrate spectrum amino acid:sodium cotransporter that promotes absorption of the D isomers of essential amino acids. Neutral amino acids are the preferred substrates, especially methionine and phenylalanine., [UniProtKB, UniProtKB, UniProtKB]",
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        "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015179 L-amino acid transmembrane transporter activity;GO:0046872 metal ion binding;GO:0005283 amino acid:sodium symporter activity;GO:0005416 amino acid:monoatomic cation symporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0035725 sodium ion transmembrane transport;GO:0003333 amino acid transmembrane transport;GO:0006836 neurotransmitter transport;GO:1903804 glycine import across plasma membrane;GO:0006814 sodium ion transport",
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        ],
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            {
                "id": "A1Z935_DROME",
                "url": "https://www.uniprot.org/uniprot/A1Z935",
                "type": "external"
            }
        ],
        "mass": 72897.0,
        "length": 660,
        "protein_name": "Proton-coupled zinc antiporter SLC30A9, mitochondrial",
        "gene_name": "ZnT49B",
        "organism": "Fruit fly",
        "refseq_name": "zinc transporter 49B, isoform B",
        "refseq_ac": [
            {
                "id": "NP_725207",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_725207",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZnT49B; CG8632; Dmel\\CG8632; Dmel_CG8632; ZNT49B; cg8632; dZnT49B",
        "gene_names_refseq": "CG8632; Dmel\\CG8632; ZNT49B; ZnT49B; cg8632; dZnT49B",
        "protein_names_uniprotkb": "Proton-coupled zinc antiporter SLC30A9, mitochondrial; Solute carrier family 30 member 9; Zinc transporter 9",
        "protein_names_refseq": "CG8632-PB; ZnT49B-PB; zinc transporter 49B, isoform B",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG8632)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "",
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0015297 antiporter activity;GO:0008324 monoatomic cation transmembrane transporter activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0031966 mitochondrial membrane",
        "go_biological_process": "GO:0006829 zinc ion transport;GO:0006351 DNA-templated transcription;GO:0006882 intracellular zinc ion homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "A1Z935-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
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            {
                "id": "A1Z9E3_DROME",
                "url": "https://www.uniprot.org/uniprot/A1Z9E3",
                "type": "external"
            }
        ],
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        "length": 489,
        "protein_name": "Elongation factor Tu",
        "gene_name": "mEFTu1",
        "organism": "Fruit fly",
        "refseq_name": "mitochondrial translation elongation factor Tu 1, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001163144",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163144",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "mEFTu1; CG6050; Dmel\\CG6050; Dmel_CG6050; EF-Tu1; EfTuM; TUFm; dTUFm; efTuM; eftu-M; l(3)L4569; mtEF-Tu",
        "gene_names_refseq": "CG6050; Dmel\\CG6050; EF-Tu1; EfTuM; TUFm; dTUFm; efTuM; eftu-M; l(3)L4569; mEFTu1; mtEF-Tu",
        "protein_names_uniprotkb": "Elongation factor Tu",
        "protein_names_refseq": "CG6050-PB; elongation factor Tu mitochondrial; mEFTu1-PB; mitochondrial translation elongation factor Tu 1, isoform B; translation elongation factor Tu",
        "tax_id": 7227,
        "disease": "chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); combined oxidative phosphorylation deficiency 4 (Disease Ontology:DOID:0111494)",
        "pathway": " (dme:Dmel_CG6050)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "GTP hydrolase that promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Participates in mitochondrial translation. Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy., [UniProtKB, UniProtKB]; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis., [UniProtKB, UniProtKB]",
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        "missing_score": 10000,
        "biomarker_type": "",
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        "glyco_site_count": 0,
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        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "3.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "3.6.5.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003746 translation elongation factor activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0070125 mitochondrial translational elongation;GO:0006414 translational elongation;GO:1902775 mitochondrial large ribosomal subunit assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
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        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A1Z9G4-1",
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            {
                "id": "A1Z9G4_DROME",
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            }
        ],
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        "protein_name": "Uncharacterized protein",
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        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_610893",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610893",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG12464; CG12464; Dmel_CG12464",
        "gene_names_refseq": "CG12464; Dmel\\CG12464",
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        "protein_names_refseq": "CG12464-PA; uncharacterized protein",
        "tax_id": 7227,
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        "go_cellular_component": "GO:0005739 mitochondrion;GO:0045271 respiratory chain complex I",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A1Z9I0-1",
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            {
                "id": "A1Z9I0_DROME",
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            }
        ],
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        "protein_name": "Cathepsin propeptide inhibitor domain-containing protein",
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        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_610907",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610907",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG6357; CG6357; Dmel_CG6357",
        "gene_names_refseq": "CG6357; Dmel\\CG6357",
        "protein_names_uniprotkb": "Cathepsin propeptide inhibitor domain-containing protein",
        "protein_names_refseq": "CG6357-PA; uncharacterized protein",
        "tax_id": 7227,
        "disease": "",
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        "kg_view_protein": true
    },
    {
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            {
                "id": "A1Z9M5_DROME",
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                "type": "external"
            }
        ],
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        "protein_name": "SAXO downstream of blistered",
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        "organism": "Fruit fly",
        "refseq_name": "SAXO downstream of blistered",
        "refseq_ac": [
            {
                "id": "NP_610937",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610937",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Sdb; CG13017; CG30069; CG8381; Dmel\\CG30069; Dmel_CG30069",
        "gene_names_refseq": "CG13017; CG30069; CG8381; Dmel\\CG30069; Sdb",
        "protein_names_uniprotkb": "SAXO downstream of blistered",
        "protein_names_refseq": "CG30069-PA; SAXO downstream of blistered; Sdb-PA",
        "tax_id": 7227,
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        "pathway": " (dme:Dmel_CG30069)",
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        "publication_count": 12,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;40245499",
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        "go_molecular_function": "GO:0008017 microtubule binding",
        "go_cellular_component": "GO:0005856 cytoskeleton;GO:0036126 sperm flagellum;GO:0005814 centriole;GO:0036064 ciliary basal body;GO:0005879 axonemal microtubule",
        "go_biological_process": "GO:0031122 cytoplasmic microtubule organization;GO:0007476 imaginal disc-derived wing morphogenesis;GO:0035220 wing disc development",
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                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_725387",
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        ],
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        "protein_names_uniprotkb": "Odorant-binding protein 50c",
        "protein_names_refseq": "CG30072-PC; Obp50c-PC; Odorant-binding protein 50c",
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        "go_molecular_function": "GO:0005549 odorant binding",
        "go_cellular_component": "GO:0005576 extracellular region",
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        "protein_names_uniprotkb": "Datilografo, isoform A; Datilografo, isoform C",
        "protein_names_refseq": "CG2052-PC; dati-PC; datilografo, isoform C",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG2052)",
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        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003677 DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0008344 adult locomotory behavior;GO:0031175 neuron projection development;GO:0048699 generation of neurons;GO:0045925 positive regulation of female receptivity;GO:0016319 mushroom body development",
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        "kg_view_protein": true
    },
    {
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            {
                "id": "H9XVM9_DROME",
                "url": "https://www.uniprot.org/uniprot/H9XVM9",
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            }
        ],
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        "length": 905,
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        "gene_name": "Dmel\\CG1674",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform L",
        "refseq_ac": [
            {
                "id": "NP_001245414",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245414",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG1674; CG1674; Dmel_CG1674",
        "gene_names_refseq": "CG1674; Dmel\\CG1674",
        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG1674-PL; uncharacterized protein, isoform L",
        "tax_id": 7227,
        "disease": "chronic kidney disease (Disease Ontology:DOID:784)",
        "pathway": " (dme:Dmel_CG1674)",
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        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;40245499",
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        "go_cellular_component": "GO:0030018 Z disc;GO:0005634 nucleus;GO:0015629 actin cytoskeleton",
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    },
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            {
                "id": "M9NGY4_DROME",
                "url": "https://www.uniprot.org/uniprot/M9NGY4",
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            }
        ],
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        "protein_name": "YLP motif-containing protein 1",
        "gene_name": "ZAP3",
        "organism": "Fruit fly",
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        "refseq_ac": [
            {
                "id": "NP_001245607",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245607",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZAP3; CG12646; CG12647; CG2971; CG32685; Dmel\\CG32685; Dmel_CG32685; Zap3",
        "gene_names_refseq": "CG12646; CG12647; CG2971; CG32685; Dmel\\CG32685; ZAP3; Zap3",
        "protein_names_uniprotkb": "YLP motif-containing protein 1; Nuclear protein ZAP3",
        "protein_names_refseq": "CG32685-PE; ZAP3, isoform E; ZAP3-PE",
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        "class_list": "",
        "function": "Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
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    },
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            {
                "id": "Q7KTF8_DROME",
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            }
        ],
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        "protein_name": "Nicotinic acetylcholine receptor alpha6, isoform E",
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        "organism": "Fruit fly",
        "refseq_name": "nicotinic acetylcholine receptor alpha6, isoform E",
        "refseq_ac": [
            {
                "id": "NP_995675",
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            }
        ],
        "gene_names_uniprotkb": "nAChRalpha6; AChRalpha6; BcDNA:GH01410; CG4128; CT13662; Dalpha6; Dmel\\CG4128; Dmel_CG4128; alpha6; dalpha6; das; nACRalpha-30D; nAChR alpha 6; nAChR-alpha30D; nAChRAlpha-30D; nAChRalpha-30D; nAChRalpha; nAChR; nAChralpha6; nAcR-alpha-30D; nAcRalpha-30D; nAchR_alpha6; rsn",
        "gene_names_refseq": "AChRalpha6; BcDNA:GH01410; CG4128; CT13662; Dalpha6; Dmel\\CG4128; alpha6; dalpha6; das; nACRalpha-30D; nAChR alpha 6; nAChR-alpha30D; nAChRAlpha-30D; nAChRalpha-30D; nAChRalpha6; nAChRalpha; nAChR; nAChralpha6; nAcRalpha-30D; nAchR_alpha6; rsn",
        "protein_names_uniprotkb": "Nicotinic acetylcholine receptor alpha6, isoform E",
        "protein_names_refseq": "CG4128-PE; Dalpha6; alpha6 nicotinic acetylcholine receptor subunit; nAChRalpha6-PE; nicotinic acetylcholine receptor 30D; nicotinic acetylcholine receptor alpha 30D; nicotinic acetylcholine receptor alpha6, isoform E; resistance to spinosyn; resistant to spinosyns",
        "tax_id": 7227,
        "disease": "nicotine dependence (Disease Ontology:DOID:0050742); Alzheimer's disease (Disease Ontology:DOID:10652); Lewy body dementia (Disease Ontology:DOID:12217); lung cancer (Disease Ontology:DOID:1324); cognitive disorder (Disease Ontology:DOID:1561); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); schizophrenia (Disease Ontology:DOID:5419); rheumatoid arthritis (Disease Ontology:DOID:7148); malignant pleural mesothelioma (Disease Ontology:DOID:7474); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778)",
        "pathway": " (dme:Dmel_CG4128);  (R-DME-629594)",
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        "function": "After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
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        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity",
        "go_cellular_component": "GO:0005892 acetylcholine-gated channel complex;GO:0045211 postsynaptic membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse",
        "go_biological_process": "GO:0046716 muscle cell cellular homeostasis;GO:0006812 monoatomic cation transport;GO:0007271 synaptic transmission, cholinergic;GO:0042391 regulation of membrane potential;GO:0034220 monoatomic ion transmembrane transport",
        "synthesized_glycan_count": 0,
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        "kg_view_protein": true
    },
    {
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            {
                "id": "B6VQ99_DROME",
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            }
        ],
        "mass": 43234.0,
        "length": 382,
        "protein_name": "Neuroectoderm-expressed 2, isoform A",
        "gene_name": "Neu2",
        "organism": "Fruit fly",
        "refseq_name": "Neuroectoderm-expressed 2, isoform A",
        "refseq_ac": [
            {
                "id": "NP_649316",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649316",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Neu2; CG7204; Dmel\\CG7204; Dmel_CG7204; neu2",
        "gene_names_refseq": "CG7204; Dmel\\CG7204; Neu2; neu2",
        "protein_names_uniprotkb": "Neuroectoderm-expressed 2, isoform A",
        "protein_names_refseq": "CG7204-PA; Neu2-PA; Neuroectoderm-expressed 2, isoform A",
        "tax_id": 7227,
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        "pathway": " (dme:Dmel_CG7204)",
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        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus",
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    },
    {
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                "id": "Q8IQI0_DROME",
                "url": "https://www.uniprot.org/uniprot/Q8IQI0",
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        ],
        "mass": 131383.0,
        "length": 1294,
        "protein_name": "Sin3A-associated protein 130, isoform C",
        "gene_name": "Sap130",
        "organism": "Fruit fly",
        "refseq_name": "Sin3A-associated protein 130, isoform C",
        "refseq_ac": [
            {
                "id": "NP_729834",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_729834",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Sap130; BcDNA:LD21213; CG11006; Dmel\\CG11006; Dmel_CG11006; SAP130; l(3)06924",
        "gene_names_refseq": "BcDNA:LD21213; CG11006; Dmel\\CG11006; SAP130; Sap130; l(3)06924",
        "protein_names_uniprotkb": "Sin3A-associated protein 130, isoform C",
        "protein_names_refseq": "CG11006-PC; Sap130-PC; Sin3A-Associated protein; Sin3A-associated protein 130, isoform C; lethal (3) 06924",
        "tax_id": 7227,
        "disease": "congenital heart disease (Disease Ontology:DOID:1682); hypoplastic left heart syndrome (Disease Ontology:DOID:9955)",
        "pathway": " (dme:Dmel_CG11006)",
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        ],
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        "protein_name": "Otopetrin-like a, isoform C",
        "gene_name": "OtopLa",
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        "refseq_name": "Otopetrin-like a, isoform C",
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            {
                "id": "NP_001162676",
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            }
        ],
        "gene_names_uniprotkb": "OtopLa; CG11473; CG17761; CG42492; Dmel\\CG42492; Dmel_CG42492; OtopLA; anon-WO0140519.181; dmOTOPLa; dm_OtopLa; otopla",
        "gene_names_refseq": "CG11473; CG17761; CG42492; Dmel\\CG42492; OtopLA; OtopLa; anon-WO0140519.181; dmOTOPLa; dm_OtopLa; otopla",
        "protein_names_uniprotkb": "Otopetrin-like a, isoform C",
        "protein_names_refseq": "CG42492-PC; OtopLa-PC; Otopetrin-like a, isoform C",
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        "refseq_ac": [
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                "id": "NP_001033980",
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        "protein_names_refseq": "CG34057-PA; uncharacterized protein, isoform A",
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        "class_list": "glycogene;glycosyltransferase",
        "function": "Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins., [UniProtKB, UniProtKB, UniProtKB]",
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        "disease": "autosomal dominant nonsyndromic deafness 88 (Disease Ontology:DOID:0070611); aortic dissection (Disease Ontology:DOID:0080685); central conducting lymphatic anomaly (Disease Ontology:DOID:0081030); cataract 6 multiple types (Disease Ontology:DOID:0110229); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); malaria (Disease Ontology:DOID:12365); cognitive disorder (Disease Ontology:DOID:1561); pancreatic cancer (Disease Ontology:DOID:1793); blood platelet disease (Disease Ontology:DOID:2218); hemangiopericytoma (Disease Ontology:DOID:264); cystic kidney disease (Disease Ontology:DOID:2975); middle cerebral artery infarction (Disease Ontology:DOID:3525); toxic encephalopathy (Disease Ontology:DOID:3602); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myocardial infarction (Disease Ontology:DOID:5844); lymphatic system disease (Disease Ontology:DOID:75); ulcerative colitis (Disease Ontology:DOID:8577); irritable bowel syndrome (Disease Ontology:DOID:9778)",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
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            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
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                "id": "3.1.4.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4",
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            {
                "id": "3.4.23.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-",
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                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
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                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
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                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
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            {
                "id": "3.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5",
                "type": "external"
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            {
                "id": "3.4.19.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12",
                "type": "external"
            },
            {
                "id": "3.4.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-",
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                "id": "2.7.11.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25",
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        "go_biological_process": "GO:0030154 cell differentiation;GO:0048013 ephrin receptor signaling pathway;GO:0007422 peripheral nervous system development;GO:0009653 anatomical structure morphogenesis;GO:0016319 mushroom body development",
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        "protein_name": "5.6.1.8; Myosin 28B1, isoform B",
        "gene_name": "Myo28B1",
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                "id": "NP_723294",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_723294",
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        ],
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        "gene_names_refseq": "28B; CG6976; DmVIIB; Dmel\\CG6976; Myo18; Myo28B1; Myo28B; VIIb 28B; myo 28B1; myo28B",
        "protein_names_uniprotkb": "5.6.1.8; Myosin 28B1, isoform B",
        "protein_names_refseq": "CG6976-PB; Myo28B1-PB; myosin 28B1, isoform B; myosin VII (28B); myosin VII 28B1-B4; myosin VIIB",
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        "go_cellular_component": "GO:0005737 cytoplasm;GO:0016459 myosin complex;GO:0071944 cell periphery;GO:0015629 actin cytoskeleton;GO:0016020 membrane",
        "go_biological_process": "GO:0048731 system development;GO:0030048 actin filament-based movement;GO:0009888 tissue development;GO:0048513 animal organ development;GO:0009653 anatomical structure morphogenesis",
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            {
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            {
                "id": "NP_001262221",
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            }
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                "id": "NP_001036767",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036767",
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        "protein_names_refseq": "CG11958-PD; Calnexin99A; Cnx99A-PD; calnexin 99A, isoform D; calnexin",
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        "pathway": " (dme:Dmel_CG11958);  (R-DME-901042)",
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        "function": "Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Required for embryogenesis and larval development under heat and ER stress conditions. May be important for germ cell development. Involved in neuronal necrotic cell death., [UniProtKB, UniProtKB, UniProtKB]",
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        "go_biological_process": "GO:0006457 protein folding;GO:0050821 protein stabilization;GO:0036503 ERAD pathway;GO:0010522 regulation of calcium ion transport into cytosol;GO:0016063 rhodopsin biosynthetic process",
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        ],
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        "protein_name": "Myosin heavy chain-like, isoform B",
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            {
                "id": "NP_732109",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_732109",
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        "protein_names_refseq": "CG30275-PM; uncharacterized protein, isoform M",
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        "disease": "oligoasthenoteratozoospermia (Disease Ontology:DOID:0070311); spermatogenic failure 84 (Disease Ontology:DOID:0070583)",
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        "go_molecular_function": "GO:0016491 oxidoreductase activity",
        "go_cellular_component": "GO:0036126 sperm flagellum",
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        "protein_name": "Rho GTPase activating protein at 102A, isoform D",
        "gene_name": "RhoGAP102A",
        "organism": "Fruit fly",
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        ],
        "gene_names_uniprotkb": "RhoGAP102A; BP1050; CG1748; CG34013; CG42316; Dm_4:1183; Dmel\\CG42316; Dmel_CG42316; mlncRNA102B1; rhoGAP102A",
        "gene_names_refseq": "BP1050; CG1748; CG34013; CG42316; Dm_4:1183; Dmel\\CG42316; RhoGAP102A; mlncRNA102B1; rhoGAP102A",
        "protein_names_uniprotkb": "Rho GTPase activating protein at 102A, isoform D",
        "protein_names_refseq": "CG42316-PD; Rho GTPase activating protein at 102A, isoform D; RhoGAP102A-PD",
        "tax_id": 7227,
        "disease": "microphthalmia (Disease Ontology:DOID:10629); long QT syndrome (Disease Ontology:DOID:2843)",
        "pathway": " (dme:Dmel_CG42316);  (R-DME-8980692);  (R-DME-9013423)",
        "pathway_count": 3,
        "publication_count": 11,
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        "function": "",
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        "predicted_o_glycosites": 1,
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        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "disease_count": 2,
        "glyco_site_count": 1,
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005096 GTPase activator activity",
        "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0005856 cytoskeleton",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007015 actin filament organization;GO:1902533 positive regulation of intracellular signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
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        "kg_view_protein": true
    },
    {
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        "uniprot_id": [
            {
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            }
        ],
        "mass": 154626.0,
        "length": 1394,
        "protein_name": "No long nerve cord, isoform C; No long nerve cord, isoform E",
        "gene_name": "nolo",
        "organism": "Fruit fly",
        "refseq_name": "no long nerve cord, isoform C",
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            {
                "id": "NP_001036374",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036374",
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            }
        ],
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        "gene_names_refseq": "CG13236; CG2122; CG2131; CG31619; CT6940; Dmel\\CG31619; nolo",
        "protein_names_uniprotkb": "No long nerve cord, isoform C; No long nerve cord, isoform E",
        "protein_names_refseq": "CG31619-PC; no long nerve cord, isoform C; nolo-PC",
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        "pathway": " (dme:Dmel_CG31619)",
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0016787 hydrolase activity",
        "go_cellular_component": "",
        "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0007419 ventral cord development",
        "synthesized_glycan_count": 0,
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    },
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            {
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        ],
        "mass": 77020.0,
        "length": 697,
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        "gene_name": "Dmel\\CG13627",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform B",
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            {
                "id": "NP_733032",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_733032",
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            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG13627; CG13627; Dmel_CG13627",
        "gene_names_refseq": "CG13627; Dmel\\CG13627",
        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG13627-PB; uncharacterized protein, isoform B",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG13627)",
        "pathway_count": 1,
        "publication_count": 11,
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        "biomarker_type": "",
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        "go_molecular_function": "GO:0003712 transcription coregulator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex",
        "go_biological_process": "GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
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    },
    {
        "uniprot_canonical_ac": "M9NE35-1",
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            {
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        ],
        "mass": 73120.0,
        "length": 645,
        "protein_name": "Eye transformer, isoform C",
        "gene_name": "et",
        "organism": "Fruit fly",
        "refseq_name": "eye transformer, isoform C",
        "refseq_ac": [
            {
                "id": "NP_001245761",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245761",
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            }
        ],
        "gene_names_uniprotkb": "et; CG14225; Dmel\\CG14225; Dmel_CG14225; ET; Et; Latran; Lat; lat",
        "gene_names_refseq": "CG14225; Dmel\\CG14225; ET; Et; Latran; Lat; et; lat",
        "protein_names_uniprotkb": "Eye transformer, isoform C",
        "protein_names_refseq": "CG14225-PC; Eye transformer; et-PC; eye transformer, isoform C; latran",
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        "disease": "",
        "pathway": " (dme:Dmel_CG14225)",
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        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
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        "predicted_glycosites": 0,
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        "reported_s_glycosites": 0,
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        "go_molecular_function": "GO:0004896 cytokine receptor activity;GO:0097677 STAT family protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:1990782 protein tyrosine kinase binding",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "GO:0042742 defense response to bacterium;GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT",
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        ],
        "mass": 30767.0,
        "length": 295,
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        "refseq_ac": [
            {
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            }
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        "gene_names_refseq": "CDK2AP1; CG18292; DOC1; Dmel\\CG18292; anon-WO03040301.144",
        "protein_names_uniprotkb": "CDK2-associated protein 1, isoform B",
        "protein_names_refseq": "CDK2-associated protein 1, isoform B; CDK2AP1-PB; CG18292-PB; deleted in oral cancer 1",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG18292);  (R-DME-9937850);  (R-DME-9940951)",
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        ],
        "mass": 170573.0,
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        "function": "May play a role in DNA-protein cross-links (DPCs) clearance, ensuring the genomic stability by protecting germ cells and early embryos from various sources of damage (PubMed:31839537). Limits replication stress and DNA double-strand breaks (PubMed:31839537)., [UniProtKB, PubMed]",
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                "id": "3.3.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.2",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0047408 alkenylglycerophosphocholine hydrolase activity;GO:0016787 hydrolase activity",
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            {
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                "url": "https://www.uniprot.org/uniprot/Q3KN41",
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            }
        ],
        "mass": 199615.0,
        "length": 1840,
        "protein_name": "Neurexin 1",
        "gene_name": "Nrx-1",
        "organism": "Fruit fly",
        "refseq_name": "neurexin 1, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001163687",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163687",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Nrx-1; CG7050; CT21808; DNrx; Dmel\\CG7050; Dmel_CG7050; Dnrx; Nrx-I; Nrx1; Nrx; dNRXN3; dNrx; dnrx-1; dnrx1; dnrx; neurexin; nrx-1; nrx1; nrx",
        "gene_names_refseq": "CG7050; CT21808; DNrx; Dmel\\CG7050; Dnrx; Nrx-1; Nrx-I; Nrx1; Nrx; dNRXN3; dNrx; dnrx-1; dnrx1; dnrx; neurexin; nrx-1; nrx1; nrx",
        "protein_names_uniprotkb": "Neurexin 1",
        "protein_names_refseq": "CG7050-PB; Neurexin-1; Neurexin-like; Nrx-1-PB; drosophila neurexin; neurexin 1, isoform B; neurexin 1; neurexin",
        "tax_id": 7227,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); autism spectrum disorder (Disease Ontology:DOID:0060041); Pitt-Hopkins-like syndrome 2 (Disease Ontology:DOID:0111332); transient cerebral ischemia (Disease Ontology:DOID:224); schizophrenia (Disease Ontology:DOID:5419)",
        "pathway": " (dme:Dmel_CG7050);  (R-DME-6794361)",
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        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17498701;17569856;17569867;17785181;19379781;20559439;22864612;23352167;25589440;26109356;26109357;26201245;26471740",
        "class_list": "",
        "function": "Neuronal cell adhesion protein involved in synapse formation, development of synaptic active zones, synaptic regulation and visual function (PubMed:17498701, PubMed:17785181, PubMed:19379781, PubMed:20559439, PubMed:22864612, PubMed:23352167, PubMed:26201245, PubMed:26471740). Plays a role in cell adhesion between the pre- and the postsynaptic cell (PubMed:17785181). Required for proper proliferation of synaptic boutons during larval development, a process necessary for coordinated matching of pre-and postsynaptic compartments (PubMed:17785181). Promotes presynaptic active zone formation and neurotransmitter release (PubMed:20559439). Spn/Spinophilin fine-tunes nrx-1/nlg1 signaling at the pre-synapse to control active zone number and functionality and thereby optimizing action potential-induced exocytosis (PubMed:26471740). Required for synapse formation in central nervous system (PubMed:17498701). By regulating synapse formation, may play a role in larval associative learning (PubMed:17498701, PubMed:19379781). Together with RhoGAP100F/syd-1, controls synapse formation at the neuromuscular junction (PubMed:22864612). Essential for synaptic vesicle cycling, which plays critical roles in neurotransmission at neuromuscular junctions (NMJ) (PubMed:19379781). Regulated and restricts formation of glutamate receptor clusters (PubMed:20559439). Mediates retinoid transport and subsequent rhodopsin maturation and may regulate lipoprotein function; thereby playing a role in vision (PubMed:23352167). Regulates sleep, circadian rhythm and synaptic plasticity (PubMed:26201245). Together with CASK, required for locomotion (PubMed:19379781)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
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        "go_cellular_component": "GO:0031594 neuromuscular junction;GO:0043195 terminal bouton;GO:0045211 postsynaptic membrane;GO:0042734 presynaptic membrane;GO:0061174 type I terminal bouton",
        "go_biological_process": "GO:0007274 neuromuscular synaptic transmission;GO:0008306 associative learning;GO:0050808 synapse organization;GO:0051124 synaptic assembly at neuromuscular junction;GO:0007268 chemical synaptic transmission",
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        "protein_name": "Cuticular protein 97Ea, isoform A",
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        ],
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        "protein_names_uniprotkb": "Cuticular protein 97Ea, isoform A",
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        "go_molecular_function": "GO:0008010 structural constituent of chitin-based larval cuticle",
        "go_cellular_component": "GO:0062129 chitin-based extracellular matrix",
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        ],
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        "protein_name": "Regulatory protein zeste",
        "gene_name": "BcDNA:SD21514",
        "organism": "Fruit fly",
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        "refseq_ac": [
            {
                "id": "NP_726513",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_726513",
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            }
        ],
        "gene_names_uniprotkb": "BcDNA:SD21514; CG30428; Dmel\\CG30428; Dmel_CG30428",
        "gene_names_refseq": "BcDNA:SD21514; CG30428; Dmel\\CG30428",
        "protein_names_uniprotkb": "Regulatory protein zeste",
        "protein_names_refseq": "CG30428-PA; uncharacterized protein, isoform A",
        "tax_id": 7227,
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        "class_list": "",
        "function": "Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter., [UniProtKB, UniProtKB, UniProtKB]",
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        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0017171 serine hydrolase activity;GO:0070012 oligopeptidase activity",
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        "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); hypertension (Disease Ontology:DOID:10763); thromboangiitis obliterans (Disease Ontology:DOID:12918); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); functional colonic disease (Disease Ontology:DOID:3877); rhinitis (Disease Ontology:DOID:4483); type 2 diabetes mellitus (Disease Ontology:DOID:9352); irritable bowel syndrome (Disease Ontology:DOID:9778); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)",
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        "function": "Receptor for the insect diurectic hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase., [UniProtKB, UniProtKB]",
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        "gene_names_refseq": "58/2; CG13109; CG18494; DAIB1; DmTaiman; DmTai; Dmel\\CG13109; EP(2)2630; NEST:bs13g05; TAI; Taiman; Tai; bs13g05.y1; l(2)01351; l(2)k05802; l(2)k05809; tai",
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        "protein_names_refseq": "CG13109-PG; drosophila amplified in breast cancer-1; tai-PG; taiman, isoform G; taiman",
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        "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); colorectal carcinoma (Disease Ontology:DOID:0080199); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); polycystic ovary syndrome (Disease Ontology:DOID:11612); thyroid hormone resistance syndrome (Disease Ontology:DOID:11633); hypothyroidism (Disease Ontology:DOID:1459); breast cancer (Disease Ontology:DOID:1612); prostate adenocarcinoma (Disease Ontology:DOID:2526); endometrial carcinoma (Disease Ontology:DOID:2871); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908); malignant pleural mesothelioma (Disease Ontology:DOID:7474); acute myeloid leukemia (Disease Ontology:DOID:9119); obesity (Disease Ontology:DOID:9970)",
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                "id": "NP_001262187",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262187",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Sfp78E; CG42607; Dmel\\CG42607; Dmel_CG42607",
        "gene_names_refseq": "CG42607; Dmel\\CG42607; Sfp78E",
        "protein_names_uniprotkb": "Seminal fluid protein 78E, isoform B",
        "protein_names_refseq": "CG42607-PB; Sfp78E-PB; seminal fluid protein 78E, isoform B",
        "tax_id": 7227,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "",
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0007320 insemination",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "M9PG65-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "M9PG98-1",
        "uniprot_id": [
            {
                "id": "M9PG98_DROME",
                "url": "https://www.uniprot.org/uniprot/M9PG98",
                "type": "external"
            }
        ],
        "mass": 114263.0,
        "length": 1004,
        "protein_name": "alpha-1,2-Mannosidase",
        "gene_name": "Edem1",
        "organism": "Fruit fly",
        "refseq_name": "ER degradation enhancer, mannosidase alpha-like 1, isoform E",
        "refseq_ac": [
            {
                "id": "NP_001259152",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259152",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Edem1; CG3810; DM-pI; Dmel\\CG3810; Dmel_CG3810; EDEM1; EG.86E4.2; EG:86E4.2; dEDEM1; edem1",
        "gene_names_refseq": "CG3810; DM-pI; Dmel\\CG3810; EDEM1; EG.86E4.2; EG:86E4.2; Edem1; dEDEM1; edem1",
        "protein_names_uniprotkb": "alpha-1,2-Mannosidase; 3.2.1.-",
        "protein_names_refseq": "CG3810-PE; ER degradation enhancer, mannosidase alpha-like 1, isoform E; Edem1-PE",
        "tax_id": 7227,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2. Seems to recognize and bind to exposed hydrophobic regions in target proteins., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0044322 endoplasmic reticulum quality control compartment",
        "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0036503 ERAD pathway;GO:1904380 endoplasmic reticulum mannose trimming;GO:1904154 positive regulation of retrograde protein transport, ER to cytosol",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "M9PG98-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.010000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IQX8-1",
        "uniprot_id": [
            {
                "id": "Q8IQX8_DROME",
                "url": "https://www.uniprot.org/uniprot/Q8IQX8",
                "type": "external"
            }
        ],
        "mass": 62361.0,
        "length": 564,
        "protein_name": "histidine--tRNA ligase",
        "gene_name": "HisRS",
        "organism": "Fruit fly",
        "refseq_name": "Histidyl-tRNA synthetase, isoform D",
        "refseq_ac": [
            {
                "id": "NP_573305",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573305",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HisRS; Aats-his; CG6335; Dmel\\CG6335; Dmel_CG6335; HRS; Harsl; dHARS; l(1)G0165; l(1)G0358",
        "gene_names_refseq": "Aats-his; CG6335; Dmel\\CG6335; HRS; Harsl; HisRS; dHARS; l(1)G0165; l(1)G0358",
        "protein_names_uniprotkb": "histidine--tRNA ligase; 6.1.1.21",
        "protein_names_refseq": "CG6335-PD; HisRS-PD; Histidyl-tRNA synthetase, isoform D; hars",
        "tax_id": 7227,
        "disease": "Perrault syndrome (Disease Ontology:DOID:0050857); Perrault syndrome 2 (Disease Ontology:DOID:0061117); Charcot-Marie-Tooth disease, axonal type 2W (Disease Ontology:DOID:0110162); Usher syndrome type 3B (Disease Ontology:DOID:0110842); sensory peripheral neuropathy (Disease Ontology:DOID:2491)",
        "pathway": " (dme:Dmel_CG6335)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "6.1.1.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.21",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0004821 histidine-tRNA ligase activity;GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol",
        "go_biological_process": "GO:0006427 histidyl-tRNA aminoacylation;GO:0032543 mitochondrial translation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q8IQX8-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "M9PHZ1-1",
        "uniprot_id": [
            {
                "id": "M9PHZ1_DROME",
                "url": "https://www.uniprot.org/uniprot/M9PHZ1",
                "type": "external"
            }
        ],
        "mass": 63640.0,
        "length": 588,
        "protein_name": "Transcriptional adaptor 3, isoform C",
        "gene_name": "Ada3",
        "organism": "Fruit fly",
        "refseq_name": "transcriptional adaptor 3, isoform C",
        "refseq_ac": [
            {
                "id": "NP_001259667",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259667",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Ada3; ADA3; CG7098; DADA3; Dmel\\CG7098; Dmel_CG7098; HL-XIV; ada3; dADA3; dAda3; dik",
        "gene_names_refseq": "ADA3; Ada3; CG7098; DADA3; Dmel\\CG7098; HL-XIV; ada3; dADA3; dAda3; dik",
        "protein_names_uniprotkb": "Transcriptional adaptor 3, isoform C",
        "protein_names_refseq": "Ada3-PC; CG7098-PC; diskette; transcriptional adaptor 3, isoform C",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG7098);  (R-DME-5689880)",
        "pathway_count": 2,
        "publication_count": 11,
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        "class_list": "",
        "function": "",
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        "ec_number_list": [],
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000123 histone acetyltransferase complex;GO:0000124 SAGA complex;GO:0070775 H3 histone acetyltransferase complex;GO:0005700 polytene chromosome",
        "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0045815 transcription initiation-coupled chromatin remodeling",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "M9PHZ1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "M9PI14-1",
        "uniprot_id": [
            {
                "id": "M9PI14_DROME",
                "url": "https://www.uniprot.org/uniprot/M9PI14",
                "type": "external"
            }
        ],
        "mass": 21198.0,
        "length": 180,
        "protein_name": "N-alpha-acetyltransferase 20",
        "gene_name": "Naa20A",
        "organism": "Fruit fly",
        "refseq_name": "N(alpha)-acetyltransferase 20 A, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001259714",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259714",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Naa20A; CG14222; DmAAF48987; Dmel\\CG14222; Dmel_CG14222; NAA20; Naa20; dNAA20",
        "gene_names_refseq": "CG14222; DmAAF48987; Dmel\\CG14222; NAA20; Naa20A; Naa20; dNAA20",
        "protein_names_uniprotkb": "N-alpha-acetyltransferase 20; 2.3.1.254; Methionine N-acetyltransferase; N-acetyltransferase 5; N-terminal acetyltransferase B complex catalytic subunit NAA20; N-terminal acetyltransferase B complex catalytic subunit NAT5; NatB catalytic subunit",
        "protein_names_refseq": "CG14222-PB; N(alpha)-acetyltransferase 20 A, isoform B; N(alpha)-acetyltransferase 20; NAA20 ortholog; Naa20A-PB",
        "tax_id": 7227,
        "disease": "autosomal recessive intellectual developmental disorder 73 (Disease Ontology:DOID:0081233)",
        "pathway": " (dme:Dmel_CG14222)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "2.3.1.254",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.254",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:0120518 protein N-terminal-methionine acetyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0031416 NatB complex;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0043524 negative regulation of neuron apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "M9PI14-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "M9PI45-1",
        "uniprot_id": [
            {
                "id": "M9PI45_DROME",
                "url": "https://www.uniprot.org/uniprot/M9PI45",
                "type": "external"
            }
        ],
        "mass": 71304.0,
        "length": 682,
        "protein_name": "Mirror, isoform C",
        "gene_name": "mirr",
        "organism": "Fruit fly",
        "refseq_name": "mirror, isoform C",
        "refseq_ac": [
            {
                "id": "NP_001261778",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261778",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "mirr; CG10601; DH1; De1; De3; Dmel\\CG10601; Dmel_CG10601; Group F; IRO-C; Iro-C; IroC; Iro; MIRR; Mirr; Mrr; Sai; crep; cre; group F; iro-C; iro; l(3)69Ca; l(3)69Da; l(3)6D1; l(3)A5-3-42; mir; mrr",
        "gene_names_refseq": "CG10601; DH1; De1; De3; Dmel\\CG10601; Group F; IRO-C; Iro-C; IroC; Iro; MIRR; Mirr; Mrr; Sai; crep; cre; group F; iro-C; iro; l(3)69Ca; l(3)69Da; l(3)6D1; l(3)A5-3-42; mirr; mir; mrr",
        "protein_names_uniprotkb": "Mirror, isoform C",
        "protein_names_refseq": "CG10601-PC; caupalican; crepuscule; iroquis complex; iroquois; mirr-PC; mirror, isoform C; mirror; sail",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG10601)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "",
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        "protein_names_refseq": "CG5842-PB; NANCHUNG; nan-PB; nanchung, isoform B; transient receptor potential vanilloid",
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        "disease": "congenital stationary night blindness (Disease Ontology:DOID:0050534); overactive bladder syndrome (Disease Ontology:DOID:0070355); Charcot-Marie-Tooth disease axonal type 2C (Disease Ontology:DOID:0110182); autosomal dominant nonsyndromic deafness 25 (Disease Ontology:DOID:0110555); autosomal dominant distal hereditary motor neuronopathy 8 (Disease Ontology:DOID:0111215); metatropic dysplasia (Disease Ontology:DOID:0111514); parastremmatic dwarfism (Disease Ontology:DOID:0111539); scapuloperoneal spinal muscular atrophy (Disease Ontology:DOID:0111552); spondyloepiphyseal dysplasia Maroteaux type (Disease Ontology:DOID:0111553); spondylometaphyseal dysplasia Kozlowski type (Disease Ontology:DOID:0111554); focal nonepidermolytic palmoplantar keratoderma 2 (Disease Ontology:DOID:0111711); autosomal dominant mutilating palmoplantar keratoderma with periorificial keratotic plaques (Disease Ontology:DOID:0112013); migraine with aura (Disease Ontology:DOID:10024); osteonecrosis (Disease Ontology:DOID:10159); pre-eclampsia (Disease Ontology:DOID:10591); gastric ulcer (Disease Ontology:DOID:10808); sciatic neuropathy (Disease Ontology:DOID:11446); gestational diabetes (Disease Ontology:DOID:11714); hyperparathyroidism (Disease Ontology:DOID:13543); reflex epilepsy (Disease Ontology:DOID:2548); dermatitis (Disease Ontology:DOID:2723); atopic dermatitis (Disease Ontology:DOID:3310); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); migraine (Disease Ontology:DOID:6364); pulmonary hypertension (Disease Ontology:DOID:6432); cocaine abuse (Disease Ontology:DOID:809); rosacea (Disease Ontology:DOID:8881); colorectal cancer (Disease Ontology:DOID:9256); diabetic neuropathy (Disease Ontology:DOID:9743); alopecia (Disease Ontology:DOID:987); cocaine dependence (Disease Ontology:DOID:9975)",
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        "protein_names_refseq": "CG2207-PF; Df31-PF; anon-fast-evolving-1A4; chromatin decondensation factor 31; decondensation factor 31, isoform F",
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        "protein_names_refseq": "ADP/ATP translocase 2; ADP/ATP translocase; Ant2-PC; CG1683-PC; adenine nucleotide translocase 2, isoform C",
        "tax_id": 7227,
        "disease": "mitochondrial DNA depletion syndrome 12a (Disease Ontology:DOID:0080130); mitochondrial DNA depletion syndrome 12b (Disease Ontology:DOID:0080335); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2 (Disease Ontology:DOID:0111517); Alzheimer's disease (Disease Ontology:DOID:10652); facioscapulohumeral muscular dystrophy (Disease Ontology:DOID:11727); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); chronic progressive external ophthalmoplegia (Disease Ontology:DOID:12558); alcoholic cardiomyopathy (Disease Ontology:DOID:12935); mitochondrial myopathy (Disease Ontology:DOID:699); mitochondrial metabolism disease (Disease Ontology:DOID:700)",
        "pathway": " (dme:Dmel_CG1683);  (R-DME-1268020);  (R-DME-83936);  (R-DME-9837999)",
        "pathway_count": 4,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane., [UniProtKB, UniProtKB]; Catalyzes the exchange of ADP and ATP across the membrane., [UniProtKB, UniProtKB]",
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        "predicted_n_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005471 ATP:ADP antiporter activity",
        "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005757 mitochondrial permeability transition pore complex",
        "go_biological_process": "GO:0006839 mitochondrial transport;GO:0046902 regulation of mitochondrial membrane permeability;GO:0140021 mitochondrial ADP transmembrane transport;GO:1990544 mitochondrial ATP transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "O62526-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
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            {
                "id": "O76861_DROME",
                "url": "https://www.uniprot.org/uniprot/O76861",
                "type": "external"
            }
        ],
        "mass": 60969.0,
        "length": 552,
        "protein_name": "Wbp11/ELF5/Saf1 N-terminal domain-containing protein",
        "gene_name": "EG:100G10.1",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_570023",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570023",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EG:100G10.1; CG2685; Dmel\\CG2685; Dmel_CG2685",
        "gene_names_refseq": "CG2685; Dmel\\CG2685; EG:100G10.1",
        "protein_names_uniprotkb": "Wbp11/ELF5/Saf1 N-terminal domain-containing protein",
        "protein_names_refseq": "CG2685-PA; uncharacterized protein",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG2685);  (R-DME-72163)",
        "pathway_count": 2,
        "publication_count": 11,
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        "biomarker_type": "",
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        "go_molecular_function": "GO:0003723 RNA binding;GO:0019888 protein phosphatase regulator activity",
        "go_cellular_component": "GO:0071013 catalytic step 2 spliceosome;GO:0071011 precatalytic spliceosome",
        "go_biological_process": "GO:0008380 RNA splicing;GO:0000398 mRNA splicing, via spliceosome",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O96660-1",
        "uniprot_id": [
            {
                "id": "SMAD2_DROME",
                "url": "https://www.uniprot.org/uniprot/O96660",
                "type": "external"
            }
        ],
        "mass": 53677.0,
        "length": 486,
        "protein_name": "SMAD family member 2",
        "gene_name": "Smox",
        "organism": "Fruit fly",
        "refseq_name": "smad on X, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001285006",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285006",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Smox; 3; CG2262; SMAD2",
        "gene_names_refseq": "CG2262; DSMAD2; DSmad2; Dmel\\CG2262; SMAD2; SMOX; Sad; Smad2/3; Smad2; Smad; SmoX; Smox; dSMAD2; dSmad2; dSmad; dsmad2; l(1)G0348; sad; smad2; smox; ted; tmp",
        "protein_names_uniprotkb": "SMAD family member 2; MAD homolog 2; Mothers against DPP homolog 2; Mothers against decapentaplegic homolog 2; Protein Smad on X; SMAD 2; dSmad2",
        "protein_names_refseq": "CG2262-PB; Smox-PB; Smox/dSmad2; sisters against dpp; smad on X, isoform B; temporarily deranged",
        "tax_id": 7227,
        "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); pre-malignant neoplasm (Disease Ontology:DOID:0060071); Loeys-Dietz syndrome 6 (Disease Ontology:DOID:0060964); Loeys-Dietz syndrome 3 (Disease Ontology:DOID:0070237); prostate cancer (Disease Ontology:DOID:10283); hypospadias (Disease Ontology:DOID:10892); alcoholic cardiomyopathy (Disease Ontology:DOID:12935); endometrial cancer (Disease Ontology:DOID:1380); alcoholic liver cirrhosis (Disease Ontology:DOID:14018); pancreatic cancer (Disease Ontology:DOID:1793); colon cancer (Disease Ontology:DOID:219); ovarian cancer (Disease Ontology:DOID:2394); breast carcinoma (Disease Ontology:DOID:3459); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); Lynch syndrome (Disease Ontology:DOID:3883); lung non-small cell carcinoma (Disease Ontology:DOID:3908); ovarian carcinoma (Disease Ontology:DOID:4001); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); myocardial infarction (Disease Ontology:DOID:5844); hepatocellular carcinoma (Disease Ontology:DOID:684); osteoarthritis (Disease Ontology:DOID:8398); cocaine dependence (Disease Ontology:DOID:9975)",
        "pathway": " (dme:Dmel_CG2262);  (R-DME-1181150);  (R-DME-1502540);  (R-DME-2173788);  (R-DME-2173789);  (R-DME-2173795);  (R-DME-2173796);  (R-DME-5689880);  (R-DME-8941855);  (R-DME-9617828)",
        "pathway_count": 10,
        "publication_count": 15,
        "publication_id_list": "10320478;10731132;12537572;12581521;16437159;16951053;17119022;18171686;18820452;19766717;22563507;29615416;38913612;9813169;9887103",
        "class_list": "",
        "function": "Receptor-regulated SMAD (R-SMAD) involved in the activin-like TGF-beta pathway (PubMed:10320478). Acts downstream of the type I transmembrane receptor serine/threonine kinase babo (PubMed:10320478). Competitively regulates phosphorylation of Mad, the R-SMAD of the BMP signaling pathway, by babo (PubMed:22563507). Heterodimerizes with the Co-SMAD Med/medea upon activation of the activin pathway and translocates to the nucleus, where it transcriptionally activates activin-responsive genes (PubMed:10320478). Involved in axonal and dendritic pruning and neural remodeling of mushroom body gamma neurons during metamorphosis, probably through regulating expression of the ecdysteroid receptor EcR (PubMed:12581521). Involved in differentiation of dorsal cluster and ellipsoid body adult-specific neurons prior to metamorphosis (PubMed:16437159). Required for axon guidance or outgrowth of ISNb and SNa axons (PubMed:17119022). Involved in regulation of wing imaginal disc growth (PubMed:18820452). Signaling by daw or myo is involved in lifespan determination through regulation of proteasome-mediated degradation of misfolded or damaged proteins (PubMed:29615416)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
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        "biomarker_type": "",
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        "secondary_ac_list": "Q86NL2",
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        "go_molecular_function": "GO:0070410 co-SMAD binding;GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0031490 chromatin DNA binding",
        "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005634 nucleus;GO:0005829 cytosol",
        "go_biological_process": "GO:0045819 positive regulation of glycogen catabolic process;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050803 regulation of synapse structure or activity",
        "synthesized_glycan_count": 0,
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    },
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        ],
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        "length": 78,
        "protein_name": "Brother of bearded A",
        "gene_name": "BobA",
        "organism": "Fruit fly",
        "refseq_name": "brother of bearded A",
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            {
                "id": "NP_525087",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525087",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "BobA; Bob-A; Bob; CG12487; Dmel\\CG12487; Dmel_CG12487; bobA",
        "gene_names_refseq": "Bob-A; BobA; Bob; CG12487; Dmel\\CG12487; bobA",
        "protein_names_uniprotkb": "Brother of bearded A",
        "protein_names_refseq": "BobA-PA; CG12487-PA; brother of bearded A; brother of bearded",
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        "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding",
        "go_cellular_component": "",
        "go_biological_process": "GO:0001708 cell fate specification;GO:0042742 defense response to bacterium;GO:0045746 negative regulation of Notch signaling pathway;GO:0016360 sensory organ precursor cell fate determination",
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        ],
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        "organism": "Fruit fly",
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            {
                "id": "NP_525000",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525000",
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            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG13465; CG13465; Dmel_CG13465",
        "gene_names_refseq": "CG13465; Dmel\\CG13465",
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        "protein_names_refseq": "CG13465-PA; uncharacterized protein",
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        "protein_name": "FAS1 domain-containing protein",
        "gene_name": "Dmel\\CG5758",
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        "refseq_name": "uncharacterized protein, isoform D",
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                "id": "NP_001286028",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286028",
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            }
        ],
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        "gene_names_refseq": "CG5758; Dmel\\CG5758",
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        "protein_names_refseq": "CG5758-PD; uncharacterized protein, isoform D",
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        ],
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                "id": "NP_995958",
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        ],
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        "protein_names_uniprotkb": "Repressor of RNA polymerase III transcription MAF1",
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        "function": "Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA., [UniProtKB, UniProtKB]",
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        ],
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        "protein_name": "Dpr-interacting protein lambda",
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            {
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        "tax_id": 7227,
        "disease": "primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); uterine fibroid (Disease Ontology:DOID:13223); ovary epithelial cancer (Disease Ontology:DOID:2152); ovarian cancer (Disease Ontology:DOID:2394); congestive heart failure (Disease Ontology:DOID:6000)",
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        ],
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        "protein_name": "Peptidase S1 domain-containing protein",
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            {
                "id": "NP_787956",
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        ],
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            {
                "id": "SPPL_DROME",
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        ],
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        "protein_name": "Signal peptide peptidase-like",
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        "refseq_name": "signal peptide peptidase-like, isoform D",
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            {
                "id": "NP_001163740",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163740",
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        ],
        "gene_names_uniprotkb": "SppL; CG17370; CG5901; Dmel\\CG17370; Dmel_CG17370; SPPL3; Sppl; sppL",
        "gene_names_refseq": "CG17370; CG5901; Dmel\\CG17370; SPPL3; SppL; Sppl; sppL",
        "protein_names_uniprotkb": "Signal peptide peptidase-like; 3.4.23.-; Intramembrane protease SppL",
        "protein_names_refseq": "CG17370-PD; SPP-like protein 3; SppL-PD; signal peptide peptidase-like, isoform D",
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        "class_list": "",
        "function": "Catalyzes intramembrane proteolysis of endoplasmic reticulum (ER)-resident proteins (PubMed:17517891). Targets signal peptides (PubMed:17517891). Does not act on the signal peptide of crb/protein crumbs (PubMed:20189678)., [UniProtKB, PubMed, PubMed]",
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    },
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        ],
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            {
                "id": "NP_732017",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_732017",
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            }
        ],
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            {
                "id": "NP_524341",
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            {
                "id": "NP_001027179",
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        "gene_names_refseq": "BcDNA:RH06221; BcDNA:RH46282; BcDNA:RH49003; BcDNA:SD12036; CG31305-PI; CG31305; CG6783; CT21061; Dmel\\CG6783; FABP; Fabp; anon-EST:Posey234; anon-WO0140519.12; dFABP; dFabp; fabp",
        "protein_names_uniprotkb": "Fatty acid-binding protein, muscle; M-FABP",
        "protein_names_refseq": "CG6783-PC; fabp-PC; fatty acid bindin protein; fatty acid binding protein, isoform C; fatty-acid binding protein; fatty-acid-binding protein",
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        "disease": "Charcot-Marie-Tooth disease type 1G (Disease Ontology:DOID:0111560); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Down syndrome (Disease Ontology:DOID:14250); congenital heart disease (Disease Ontology:DOID:1682); impotence (Disease Ontology:DOID:1875); glioblastoma (Disease Ontology:DOID:3068); myocardial infarction (Disease Ontology:DOID:5844); muscular atrophy (Disease Ontology:DOID:767); psoriasis (Disease Ontology:DOID:8893); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)",
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                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_723591",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LManII; BcDNA:GH02419; CG6206; Dmel\\CG6206; Dmel_CG6206; LM408; LM; dLM408; dLMII; dLManII; dLM",
        "gene_names_refseq": "BcDNA:GH02419; CG6206; Dmel\\CG6206; LM408; LManII; LM; dLM408; dLMII; dLManII; dLM",
        "protein_names_uniprotkb": "Alpha-mannosidase; 3.2.1.-",
        "protein_names_refseq": "CG6206-PB; LManII-PB; class II lysosomal alpha-mannosidase; lysosomal alpha-mannosidase II, isoform B; lysosomal alpha-mannosidase II; lysosomal alpha-mannosidase; lysosomal mannosidase",
        "tax_id": 7227,
        "disease": "alpha-mannosidosis (Disease Ontology:DOID:3413)",
        "pathway": " (dme:Dmel_CG6206);  (R-DME-6798695);  (R-DME-8853383)",
        "pathway_count": 3,
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        "class_list": "glycogene;glycosylhydrolase",
        "function": "",
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        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "3.5.2.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.17",
                "type": "external"
            },
            {
                "id": "3.2.1.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17",
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            {
                "id": "3.2.1.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31",
                "type": "external"
            },
            {
                "id": "3.5.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
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            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
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            {
                "id": "1.1.1.205",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205",
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            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "1.16.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1",
                "type": "external"
            },
            {
                "id": "3.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-",
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            },
            {
                "id": "3.4.19.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9",
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            },
            {
                "id": "3.5.1.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26",
                "type": "external"
            },
            {
                "id": "5.3.99.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3",
                "type": "external"
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            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
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            },
            {
                "id": "3.2.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23",
                "type": "external"
            },
            {
                "id": "6.3.4.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21",
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            {
                "id": "4.6.1.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19",
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            {
                "id": "3.2.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51",
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                "id": "3.5.4.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4",
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            {
                "id": "1.11.2.-",
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                "id": "2.4.1.1",
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                "id": "1.6.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004559 alpha-mannosidase activity;GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005764 lysosome",
        "go_biological_process": "GO:0006013 mannose metabolic process",
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        "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.10100",
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        ],
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        "protein_name": "Cuticular protein 31A",
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        "organism": "Fruit fly",
        "refseq_name": "cuticular protein 31A",
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            {
                "id": "NP_995678",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_995678",
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            }
        ],
        "gene_names_uniprotkb": "Cpr31A; CG33302; CG4791-PB; CG4791; Dmel\\CG33302; Dmel_CG33302",
        "gene_names_refseq": "CG33302; CG4791-PB; CG4791; Cpr31A; Dmel\\CG33302",
        "protein_names_uniprotkb": "Cuticular protein 31A",
        "protein_names_refseq": "CG33302-PA; Cpr31A-PA; cuticular protein 31A",
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        "go_molecular_function": "GO:0008010 structural constituent of chitin-based larval cuticle",
        "go_cellular_component": "GO:0031012 extracellular matrix;GO:0062129 chitin-based extracellular matrix",
        "go_biological_process": "GO:0040003 chitin-based cuticle development",
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        "length": 805,
        "protein_name": "Arouser, isoform A",
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            {
                "id": "NP_722663",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722663",
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        "gene_names_uniprotkb": "aru; CG4276; Dmel\\CG4276; Dmel_CG4276; EPS8L3",
        "gene_names_refseq": "CG4276; Dmel\\CG4276; EPS8L3; aru",
        "protein_names_uniprotkb": "Arouser, isoform A",
        "protein_names_refseq": "CG4276-PA; EPS8L3; arouser, isoform A; aru-PA",
        "tax_id": 7227,
        "disease": "autosomal recessive nonsyndromic deafness 106 (Disease Ontology:DOID:0080261); autosomal recessive nonsyndromic deafness 102 (Disease Ontology:DOID:0110463); alcohol use disorder (Disease Ontology:DOID:1574)",
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        "pathway_count": 0,
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        "go_biological_process": "GO:0042048 olfactory behavior;GO:0007613 memory;GO:0045471 response to ethanol;GO:0050803 regulation of synapse structure or activity;GO:0007266 Rho protein signal transduction",
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        "protein_name": "U1-C C2H2-type zinc finger domain-containing protein",
        "gene_name": "Snrnp20",
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        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_722687",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722687",
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        ],
        "gene_names_uniprotkb": "Snrnp20; 20K; CG31922; Dmel\\CG31922; Dmel_CG31922; anon-AE003587.1",
        "gene_names_refseq": "20K; CG31922; Dmel\\CG31922; anon-AE003587.1",
        "protein_names_uniprotkb": "U1-C C2H2-type zinc finger domain-containing protein",
        "protein_names_refseq": "CG31922-PA; uncharacterized protein",
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        "pathway": " (dme:Dmel_CG31922);  (R-DME-72165)",
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        "go_molecular_function": "GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0034693 U11/U12 snRNP;GO:0005689 U12-type spliceosomal complex",
        "go_biological_process": "GO:0000380 alternative mRNA splicing, via spliceosome",
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                "id": "NP_722789",
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        ],
        "gene_names_uniprotkb": "Dmel\\CG31681; CG31681; Dmel_CG31681; SP230",
        "gene_names_refseq": "CG31681; Dmel\\CG31681; SP230",
        "protein_names_uniprotkb": "trypsin; 3.4.21.4",
        "protein_names_refseq": "CG31681-PA; uncharacterized protein",
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        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0017171 serine hydrolase activity",
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        "protein_name": "3.-.-.-; Testis EndoG-Like 1",
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        "organism": "Fruit fly",
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        "gene_names_refseq": "BcDNA:AT02809; CG17006; CG31682; Dmel\\CG31682; Tengl1",
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        "protein_names_refseq": "CG31682-PA; Tengl1-PA; testis EndoG-Like 1",
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        "hit_score": 1.2,
        "record_id": "Q9V415-1",
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    },
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        "uniprot_canonical_ac": "Q9V4C0-1",
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            {
                "id": "YELLH_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9V4C0",
                "type": "external"
            }
        ],
        "mass": 53398.0,
        "length": 463,
        "protein_name": "Dopaminechrome tautomerase",
        "gene_name": "yellow-h",
        "organism": "Fruit fly",
        "refseq_name": "yellow-h",
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            {
                "id": "NP_651912",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651912",
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            }
        ],
        "gene_names_uniprotkb": "yellow-h; CG1629",
        "gene_names_refseq": "CG1629; DPT; Dmel\\CG1629; yell-h; yellow-h",
        "protein_names_uniprotkb": "Dopaminechrome tautomerase; 5.3.3.-; DPT; Protein yellow-h",
        "protein_names_refseq": "CG1629-PA; dopaminechrome tautomerase; yellow-h-PA; yellow-h",
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        "publication_id_list": "10731132;12537569;12537572;34388859",
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        "function": "Catalyzes the conversion of dopaminechrome to 5,6-dihydroxyindole in the eumelanin biosynthetic pathway originating from dopamine (PubMed:34388859). Catalyzes tautomerization of dopaminechrome to 5,6-dihydroxyindole during eumelanin biosynthesis (PubMed:34388859). Acts both dopaminechrome and N-methyl dopaminechrome but not on dopachrome or other aminochromes tested (PubMed:34388859)., [UniProtKB, PubMed]",
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                "id": "5.3.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-",
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            }
        ],
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        "protein_name": "G/T mismatch-specific thymine DNA glycosylase",
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        "organism": "Fruit fly",
        "refseq_name": "thymine DNA glycosylase, isoform B",
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            {
                "id": "NP_001259060",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259060",
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        "gene_names_refseq": "1981; CG1981; Dmel\\CG1981; G/T-mismatch-specific-thymine-DNA-glycosylase; MUG; TDG; THD1; Tdg; Thd1; UDG_DM_7304305; dmThd1p; thd1",
        "protein_names_uniprotkb": "G/T mismatch-specific thymine DNA glycosylase; 3.2.2.29; Thymine-DNA glycosylase",
        "protein_names_refseq": "CG1981-PB; TDG homolog of D.melanogaster; Tdg-PB; Thd1; mismatch-specific uracil DNA glycosylase; thymine DNA glycosylase, isoform B; thymine-DNA glycosylase; uracil-DNA glycosylase",
        "tax_id": 7227,
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        "pathway": " (dme:Dmel_CG1981);  (R-DME-110329);  (R-DME-110357);  (R-DME-3108214);  (R-DME-5221030)",
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                "id": "3.1.11.2",
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            },
            {
                "id": "3.1.-.-",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.29",
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            }
        ],
        "go_molecular_function": "GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity;GO:0003690 double-stranded DNA binding;GO:0004844 uracil DNA N-glycosylase activity;GO:0032183 SUMO binding;GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006298 mismatch repair;GO:0040029 epigenetic regulation of gene expression;GO:0006285 base-excision repair, AP site formation",
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            {
                "id": "RRN3_DROME",
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        ],
        "mass": 70749.0,
        "length": 611,
        "protein_name": "RNA polymerase I-specific transcription initiation factor Tif-IA",
        "gene_name": "Tif-IA",
        "organism": "Fruit fly",
        "refseq_name": "Tif-IA",
        "refseq_ac": [
            {
                "id": "NP_788084",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788084",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Tif-IA; CG16938; CG3278; CG5951; RRN3; Tif-1A",
        "gene_names_refseq": "CG16938; CG3278; CG5951; Dmel\\CG3278; TIF-1A; TIF-IA; TIF1A; TIf-IA; Tif-1A; Tif-1a; Tif-IA; TifIA; dTIF-IA; tif1a",
        "protein_names_uniprotkb": "RNA polymerase I-specific transcription initiation factor Tif-IA; Transcription initiation factor IA; dTIF-IA",
        "protein_names_refseq": "CG3278-PA; Tif-IA-PA; Tif-IA",
        "tax_id": 7227,
        "disease": "Parkinson's disease (Disease Ontology:DOID:14330)",
        "pathway": " (dme:Dmel_CG3278);  (R-DME-73762);  (R-DME-73772)",
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        "function": "Required for efficient transcription initiation by RNA polymerase I (Pol I) (PubMed:18086911). May also stimulate expression of ribosomal protein encoding mRNAs and ribosomal components normally transcribed by RNA Pol III (PubMed:18086911). Involved in determining adult lifespan and aging (PubMed:32049000). Required for cell growth during development (PubMed:18086911, PubMed:25356674). Required in muscle to drive systemic growth, possibly by affecting systemic insulin signaling (PubMed:25356674)., [UniProtKB, PubMed, PubMed, PubMed]",
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        "secondary_ac_list": "Q95RU9;Q9V9M5",
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        "go_molecular_function": "GO:0001181 RNA polymerase I general transcription initiation factor activity;GO:0001042 RNA polymerase I core binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus",
        "go_biological_process": "GO:0008340 determination of adult lifespan;GO:0006361 transcription initiation at RNA polymerase I promoter;GO:0042790 nucleolar large rRNA transcription by RNA polymerase I;GO:0036099 female germ-line stem cell population maintenance",
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    },
    {
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        ],
        "mass": 87090.0,
        "length": 773,
        "protein_name": "Uncharacterized protein",
        "gene_name": "CG2112",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
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            {
                "id": "NP_651899",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651899",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CG2112; CG11574; CG42233; Dmel\\CG42233; Dmel_CG42233",
        "gene_names_refseq": "CG11574; CG2112; CG42233; Dmel\\CG42233",
        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG42233-PB; uncharacterized protein",
        "tax_id": 7227,
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        "pathway": " (dme:Dmel_CG42233);  (R-DME-8951664)",
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        "go_cellular_component": "GO:0005737 cytoplasm;GO:0080008 Cul4-RING E3 ubiquitin ligase complex",
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        ],
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        "protein_name": "Sodium-dependent multivitamin transporter",
        "gene_name": "Smvt",
        "organism": "Fruit fly",
        "refseq_name": "Sodium-dependent multivitamin transporter",
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            {
                "id": "NP_651891",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651891",
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        ],
        "gene_names_uniprotkb": "Smvt; CG2191; Dmel\\CG2191; Dmel_CG2191; SMVT; dSLC5A5; smvt",
        "gene_names_refseq": "CG2191; Dmel\\CG2191; SMVT; Smvt; dSLC5A5; smvt",
        "protein_names_uniprotkb": "Sodium-dependent multivitamin transporter",
        "protein_names_refseq": "CG2191-PA; Smvt-PA; Sodium-dependent multivitamin transporter",
        "tax_id": 7227,
        "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); thyroid dyshormonogenesis 1 (Disease Ontology:DOID:0112185)",
        "pathway": " (dme:Dmel_CG2191)",
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        "go_molecular_function": "GO:0005412 D-glucose:sodium symporter activity;GO:0015293 symporter activity",
        "go_cellular_component": "GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0042593 glucose homeostasis;GO:0006814 sodium ion transport;GO:0098708 D-glucose import across plasma membrane",
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        "protein_name": "HotDog ACOT-type domain-containing protein",
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        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001287623",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287623",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG1774; CG1774; Dmel_CG1774",
        "gene_names_refseq": "CG1774; Dmel\\CG1774",
        "protein_names_uniprotkb": "HotDog ACOT-type domain-containing protein",
        "protein_names_refseq": "CG1774-PB; uncharacterized protein, isoform B",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG1774)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003986 acetyl-CoA hydrolase activity;GO:0047617 fatty acyl-CoA hydrolase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0006637 acyl-CoA metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9V9W4-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9V9Z3-1",
        "uniprot_id": [
            {
                "id": "Q9V9Z3_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9V9Z3",
                "type": "external"
            }
        ],
        "mass": 48973.0,
        "length": 436,
        "protein_name": "All trans-polyprenyl-diphosphate synthase PDSS1",
        "gene_name": "qless",
        "organism": "Fruit fly",
        "refseq_name": "qless, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001287619",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287619",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "qless; CG15565; CG31005; CG3684; Dmel\\CG31005; Dmel_CG31005; Qless; anon-WO0118547.422",
        "gene_names_refseq": "CG15565; CG31005; CG3684; Dmel\\CG31005; Qless; anon-WO0118547.422; qless",
        "protein_names_uniprotkb": "All trans-polyprenyl-diphosphate synthase PDSS1; 2.5.1.91; All-trans-decaprenyl-diphosphate synthase subunit 1; Decaprenyl-diphosphate synthase subunit 1; Solanesyl-diphosphate synthase subunit 1; Trans-prenyltransferase 1",
        "protein_names_refseq": "CG31005-PB; COQ1 subunit 1; qless, isoform B; qless-PB",
        "tax_id": 7227,
        "disease": "primary coenzyme Q10 deficiency 2 (Disease Ontology:DOID:0070239)",
        "pathway": " (dme:Dmel_CG31005);  (R-DME-2142789)",
        "pathway_count": 2,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone. Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9)and ubiquinone-10 (Q10) respectively. The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "2.5.1.91",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.91",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0004659 prenyltransferase activity;GO:0097269 all-trans-decaprenyl-diphosphate synthase activity;GO:0120531 prenyl diphosphate synthase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0032478 heterotetrameric polyprenyl diphosphate synthase complex;GO:0032476 polyprenyl diphosphate synthase complex",
        "go_biological_process": "GO:0006744 ubiquinone biosynthetic process;GO:0008299 isoprenoid biosynthetic process;GO:0042811 pheromone biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9V9Z3-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9V9Z5-1",
        "uniprot_id": [
            {
                "id": "Q9V9Z5_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9V9Z5",
                "type": "external"
            }
        ],
        "mass": 13388.0,
        "length": 116,
        "protein_name": "Uncharacterized protein",
        "gene_name": "Dmel\\CG15563",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_651854",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651854",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG15563; CG15563; Dmel_CG15563",
        "gene_names_refseq": "CG15563; Dmel\\CG15563",
        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG15563-PA; uncharacterized protein",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG15563)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "biomarker_type": "",
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        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9V9Z5-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VA09-1",
        "uniprot_id": [
            {
                "id": "Q9VA09_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VA09",
                "type": "external"
            }
        ],
        "mass": 86850.0,
        "length": 787,
        "protein_name": "Guanylate cyclase soluble subunit beta-1",
        "gene_name": "Gycbeta100B",
        "organism": "Fruit fly",
        "refseq_name": "guanylyl cyclase beta-subunit at 100B",
        "refseq_ac": [
            {
                "id": "NP_524603",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524603",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Gycbeta100B; CG1470; Dgc beta 1; Dgcbeta1; Dmel\\CG1470; Dmel_CG1470; Gbeta100B; Gyc-beta-100B; Gycbeta-100B; dgcb1; dgcbeta1; gyc beta; gycbeta100B; sGC-beta; sGCbeta100B; sGCbeta1",
        "gene_names_refseq": "CG1470; Dgc beta 1; Dgcbeta1; Dmel\\CG1470; Gbeta100B; Gycbeta-100B; Gycbeta100B; dgcb1; dgcbeta1; gyc beta; gycbeta100B; sGC-beta; sGCbeta100B; sGCbeta1",
        "protein_names_uniprotkb": "Guanylate cyclase soluble subunit beta-1; 4.6.1.2; Guanylate cyclase soluble subunit beta-3; Soluble guanylate cyclase small subunit",
        "protein_names_refseq": "CG1470-PA; Gycbeta100B-PA; guanylyl cyclase beta-subunit at 100B",
        "tax_id": 7227,
        "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); Alzheimer's disease (Disease Ontology:DOID:10652)",
        "pathway": " (dme:Dmel_CG1470);  (R-DME-445355)",
        "pathway_count": 2,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "4.6.1.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0020037 heme binding",
        "go_cellular_component": "GO:0008074 guanylate cyclase complex, soluble",
        "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0070482 response to oxygen levels",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9VA09-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VA17-1",
        "uniprot_id": [
            {
                "id": "Q9VA17_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VA17",
                "type": "external"
            }
        ],
        "mass": 57069.0,
        "length": 529,
        "protein_name": "Sox100B",
        "gene_name": "Sox100B",
        "organism": "Fruit fly",
        "refseq_name": "Sox100B",
        "refseq_ac": [
            {
                "id": "NP_651839",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651839",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Sox100B; CG12098; CG15552; CG18674; CT6009; Dmel\\CG15552; Dmel_CG15552; SOX100B; SOXE; Sox100; Sox9; SoxB; dSox9",
        "gene_names_refseq": "CG12098; CG15552; CG18674; CT6009; Dmel\\CG15552; SOX100B; SOXE; Sox100B; Sox100; Sox9; SoxB; dSox9",
        "protein_names_uniprotkb": "Sox100B",
        "protein_names_refseq": "CG15552-PA; Sox100B-PA; Sox100B",
        "tax_id": 7227,
        "disease": "campomelic dysplasia (Disease Ontology:DOID:0050463); PCWH syndrome (Disease Ontology:DOID:0090111); Waardenburg syndrome type 4C (Disease Ontology:DOID:0110955); Waardenburg syndrome type 2E (Disease Ontology:DOID:0110956); 46,XX sex reversal 2 (Disease Ontology:DOID:0111763); 46,XY sex reversal 10 (Disease Ontology:DOID:0111775); Hirschsprung's disease (Disease Ontology:DOID:10487); lung cancer (Disease Ontology:DOID:1324); Kallmann syndrome (Disease Ontology:DOID:3614); lung carcinoma (Disease Ontology:DOID:3905); Waardenburg syndrome (Disease Ontology:DOID:9258)",
        "pathway": " (dme:Dmel_CG15552);  (R-DME-3769402);  (R-DME-8878166);  (R-DME-9856649)",
        "pathway_count": 4,
        "publication_count": 11,
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        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008584 male gonad development",
        "synthesized_glycan_count": 0,
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        "record_id": "Q9VA17-1",
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        "kg_view_protein": true
    },
    {
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                "id": "Q9VA23_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VA23",
                "type": "external"
            }
        ],
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        "protein_name": "Uncharacterized protein",
        "gene_name": "Dmel\\CG15548",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_651836",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651836",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG15548; CG15548; Dmel_CG15548",
        "gene_names_refseq": "CG15548; Dmel\\CG15548",
        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG15548-PA; uncharacterized protein",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG15548)",
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            {
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            {
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        "function": "Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed., [UniProtKB, UniProtKB]",
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        "protein_name": "Bromodomain-containing protein 8",
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        "function": "Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of histone H4 'Lys-12' (PubMed:32432549). Component of a SWR1-like complex that incorporates H2A.V genome-wide and specifically at active promoters, in an ATP-dependent manner (PubMed:32432549). Component of the Tip60 chromatin-remodeling complex that upon induction of DNA double-strand breaks, mediates the ATP-dependent exchange of unmodified histone H2AV for its phosphorylated and acetylated form H2AVK5acS138ph, leading to transcriptional regulation of selected genes by chromatin remodeling (PubMed:15528408)., [UniProtKB, PubMed, PubMed]",
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        "go_cellular_component": "GO:0005634 nucleus;GO:0035267 NuA4 histone acetyltransferase complex",
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        "protein_name": "Phosphoglycerate mutase",
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        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008312 7S RNA binding",
        "go_cellular_component": "GO:0005786 signal recognition particle, endoplasmic reticulum targeting;GO:0005783 endoplasmic reticulum",
        "go_biological_process": "GO:0006614 SRP-dependent cotranslational protein targeting to membrane;GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9VDK7-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VDL0-1",
        "uniprot_id": [
            {
                "id": "Q9VDL0_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VDL0",
                "type": "external"
            }
        ],
        "mass": 12418.0,
        "length": 109,
        "protein_name": "Signal recognition particle 14 kDa protein",
        "gene_name": "Srp14",
        "organism": "Fruit fly",
        "refseq_name": "signal recognition particle 14",
        "refseq_ac": [
            {
                "id": "NP_650896",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650896",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Srp14; BcDNA:RE48595; CG5417; Dmel\\CG5417; Dmel_CG5417; SRP14",
        "gene_names_refseq": "BcDNA:RE48595; CG5417; Dmel\\CG5417; SRP14; Srp14",
        "protein_names_uniprotkb": "Signal recognition particle 14 kDa protein; SRP14",
        "protein_names_refseq": "CG5417-PB; Srp14-PB; signal recognition particle 14; signal recognition particle protein 14",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG5417);  (R-DME-1799339);  (R-DME-6798695)",
        "pathway_count": 3,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_snv": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030942 endoplasmic reticulum signal peptide binding;GO:0008312 7S RNA binding",
        "go_cellular_component": "GO:0005786 signal recognition particle, endoplasmic reticulum targeting",
        "go_biological_process": "GO:0045047 protein targeting to ER;GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9VDL0-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VDN4-1",
        "uniprot_id": [
            {
                "id": "Q9VDN4_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VDN4",
                "type": "external"
            }
        ],
        "mass": 60441.0,
        "length": 556,
        "protein_name": "C2H2-type domain-containing protein",
        "gene_name": "Sag1",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform A",
        "refseq_ac": [
            {
                "id": "NP_650879",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650879",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Sag1; CG4360; Dmel\\CG4360; Dmel_CG4360",
        "gene_names_refseq": "CG4360; Dmel\\CG4360",
        "protein_names_uniprotkb": "C2H2-type domain-containing protein",
        "protein_names_refseq": "CG4360-PA; uncharacterized protein, isoform A",
        "tax_id": 7227,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_snv": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9VDN4-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    }
]
