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        "uniprot_canonical_ac": "M9PEE6-1",
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            {
                "id": "M9PEE6_DROME",
                "url": "https://www.uniprot.org/uniprot/M9PEE6",
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            }
        ],
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        "length": 238,
        "protein_name": "Tetraspanin 66A, isoform E",
        "gene_name": "Tsp66A",
        "organism": "Fruit fly",
        "refseq_name": "tetraspanin 66A, isoform E",
        "refseq_ac": [
            {
                "id": "NP_001261518",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261518",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Tsp66A; CG16991; Dm.Tsp66A; Dmel\\CG16991; Dmel_CG16991",
        "gene_names_refseq": "CG16991; Dm.Tsp66A; Dmel\\CG16991; Tsp66A",
        "protein_names_uniprotkb": "Tetraspanin 66A, isoform E",
        "protein_names_refseq": "CG16991-PE; Tsp66A-PE; tetraspanin 66A, isoform E",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG16991);  (R-DME-6798695)",
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        "class_list": "",
        "function": "",
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        "biomarker_type": "",
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        "secondary_ac_list": "",
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    {
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            {
                "id": "M9PEG6_DROME",
                "url": "https://www.uniprot.org/uniprot/M9PEG6",
                "type": "external"
            }
        ],
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        "length": 545,
        "protein_name": "Zinc transporter 63C, isoform F",
        "gene_name": "ZnT63C",
        "organism": "Fruit fly",
        "refseq_name": "zinc transporter 63C, isoform F",
        "refseq_ac": [
            {
                "id": "NP_001261364",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261364",
                "type": "external"
            }
        ],
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        "gene_names_refseq": "CG17723; Dmel\\CG17723; ZNT63C; ZnT1; ZnT63C; ZnT63; cg17723; dZNT1; dZNT63C; dZnT1; dZnT63C",
        "protein_names_uniprotkb": "Zinc transporter 63C, isoform F",
        "protein_names_refseq": "CG17723-PF; ZnT63C-PF; zinc transporter 63C, isoform F",
        "tax_id": 7227,
        "disease": "hypermanganesemia with dystonia 1 (Disease Ontology:DOID:0080536)",
        "pathway": " (dme:Dmel_CG17723);  (R-DME-425410);  (R-DME-435368)",
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        "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0022883 zinc efflux transmembrane transporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0010312 detoxification of zinc ion;GO:0071577 zinc ion transmembrane transport;GO:0006882 intracellular zinc ion homeostasis;GO:0180002 renal zinc excretion",
        "synthesized_glycan_count": 0,
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        "uniprot_canonical_ac": "M9PEI0-1",
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            {
                "id": "M9PEI0_DROME",
                "url": "https://www.uniprot.org/uniprot/M9PEI0",
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            }
        ],
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        "length": 355,
        "protein_name": "Chitin-binding type-2 domain-containing protein",
        "gene_name": "Dmel\\CG13675",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform D",
        "refseq_ac": [
            {
                "id": "NP_001261563",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261563",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG13675; CG13675; Dmel_CG13675",
        "gene_names_refseq": "CG13675; Dmel\\CG13675",
        "protein_names_uniprotkb": "Chitin-binding type-2 domain-containing protein",
        "protein_names_refseq": "CG13675-PD; uncharacterized protein, isoform D",
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        "class_list": "",
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                "url": "https://www.uniprot.org/uniprot/M9PEK4",
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        "protein_name": "Uncharacterized protein",
        "gene_name": "Dmel\\CG43965",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
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            {
                "id": "NP_001261598",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261598",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG43965; CG43965; Dmel_CG43965",
        "gene_names_refseq": "CG43965; Dmel\\CG43965",
        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG43965-PA; uncharacterized protein",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG43965)",
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        "uniprot_canonical_ac": "M9PEM1-1",
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                "id": "M9PEM1_DROME",
                "url": "https://www.uniprot.org/uniprot/M9PEM1",
                "type": "external"
            }
        ],
        "mass": 38411.0,
        "length": 346,
        "protein_name": "Syntaxin 17, isoform B",
        "gene_name": "Syx17",
        "organism": "Fruit fly",
        "refseq_name": "syntaxin 17, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001261414",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261414",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Syx17; CG7452; Dm Syx17; DmSyx17; Dmel\\CG7452; Dmel_CG7452; S17; Stx17; Syx; syx17",
        "gene_names_refseq": "CG7452; Dm Syx17; DmSyx17; Dmel\\CG7452; S17; Stx17; Syx17; Syx; syx17",
        "protein_names_uniprotkb": "Syntaxin 17, isoform B",
        "protein_names_refseq": "CG7452-PB; Syntaxin17; Syx17-PB; syntaxin 17, isoform B; syntaxin",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG7452);  (R-DME-204005)",
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        "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0005776 autophagosome;GO:0031201 SNARE complex",
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        "protein_name": "Simjang, isoform E",
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        "organism": "Fruit fly",
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                "id": "NP_001261685",
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        "gene_names_refseq": "CG32067; CG7983; CG8000; Dmel\\CG32067; SIMJ; anon-WO0118547.361; dp66; l(3)01814; l(3)j4A5; l(3)rN672; p66/68-like; p66/68; p66; simj",
        "protein_names_uniprotkb": "Simjang, isoform E",
        "protein_names_refseq": "CG32067-PE; simj-PE; simjang, isoform E",
        "tax_id": 7227,
        "disease": "GAND syndrome (Disease Ontology:DOID:0070048); intellectual disability (Disease Ontology:DOID:1059)",
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        "protein_name": "Uncharacterized protein",
        "gene_name": "Dmel\\CG6282",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform D",
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            {
                "id": "NP_001261595",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261595",
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                "url": "https://www.uniprot.org/uniprot/Q9W345",
                "type": "external"
            }
        ],
        "mass": 99717.0,
        "length": 934,
        "protein_name": "Palmitoyltransferase ZDHHC8",
        "gene_name": "Zdhhc8",
        "organism": "Fruit fly",
        "refseq_name": "zinc finger DHHC-type containing 8, isoform D",
        "refseq_ac": [
            {
                "id": "NP_001245592",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245592",
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            }
        ],
        "gene_names_uniprotkb": "Zdhhc8; CG12136; CG15372; CG17251; CG32705; CG34449; Dm_X:47283; Dmel\\CG34449; Dmel_CG34449; Pen16; anon-Pen16; dZDHHC8; p16; pen16",
        "gene_names_refseq": "CG12136; CG15372; CG17251; CG32705; CG34449; Dm_X:47283; Dmel\\CG34449; Pen16; Zdhhc8; anon-Pen16; dZDHHC8; p16; pen16",
        "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC8; 2.3.1.225; Zinc finger DHHC domain-containing protein 8; Zinc finger DHHC-type containing 8",
        "protein_names_refseq": "CG34449-PD; Zdhhc8-PD; zinc finger DHHC-type containing 8, isoform D",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG34449)",
        "pathway_count": 1,
        "publication_count": 12,
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        "class_list": "",
        "function": "Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (By similarity). Regulates tissue growth possibly by regulating Ras64B protein stability (PubMed:30735487). May regulate CG34450 mRNA levels (PubMed:30735487)., [UniProtKB, UniProtKB, UniProtKB, PubMed]",
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        "secondary_ac_list": "A8JUM2;A8JUM5;M9NGX0;X2JE99;X2JJ56",
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            {
                "id": "2.3.1.225",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0016020 membrane",
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    },
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        ],
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            {
                "id": "NP_001036538",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036538",
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        ],
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        "protein_names_refseq": "CG30054-PE; uncharacterized protein, isoform E",
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        "disease": "familial hypocalciuric hypercalcemia 2 (Disease Ontology:DOID:0060701); autosomal dominant hypocalcemia 2 (Disease Ontology:DOID:0090108); familial multiple nevi flammei (Disease Ontology:DOID:0111529); Sturge-Weber syndrome (Disease Ontology:DOID:0111563); lung non-small cell carcinoma (Disease Ontology:DOID:3908); congestive heart failure (Disease Ontology:DOID:6000)",
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        "class_list": "",
        "function": "Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems., [UniProtKB, UniProtKB, UniProtKB]",
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        "go_cellular_component": "GO:0005834 heterotrimeric G-protein complex;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0032502 developmental process;GO:0050793 regulation of developmental process;GO:0000902 cell morphogenesis;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway",
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            }
        ],
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        "length": 255,
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        "gene_name": "CAHbeta",
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        "refseq_name": "carbonic anhydrase beta, isoform A",
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            {
                "id": "NP_649849",
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            }
        ],
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        "gene_names_refseq": "BCA; CAHbeta; CG11967; DmBCA; DmeCA; Dmel\\CG11967; Dmel_CG11967; beta-CA",
        "protein_names_uniprotkb": "Carbonic anhydrase; 4.2.1.1; Carbonate dehydratase",
        "protein_names_refseq": "CAHbeta-PA; CG11967-PA; GH10821P; beta-carbonic anhydrase; carbonic anhydrase beta, isoform A",
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        "class_list": "",
        "function": "Reversible hydration of carbon dioxide., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
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        ],
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        ],
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        "protein_name": "Calponin homology domain-containing protein DDB_G0272472",
        "gene_name": "CG14878; CG31291; CG34275; CG5552",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform C",
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            {
                "id": "NP_732085",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_732085",
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            }
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        "protein_names_uniprotkb": "Calponin homology domain-containing protein DDB_G0272472",
        "protein_names_refseq": "CG45105-PC; uncharacterized protein, isoform C",
        "tax_id": 7227,
        "disease": "Senior-Loken syndrome (Disease Ontology:DOID:0050576); Bardet-Biedl syndrome 16 (Disease Ontology:DOID:0110138); nephronophthisis (Disease Ontology:DOID:12712)",
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            {
                "id": "NP_650795",
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        "protein_names_refseq": "CG5237-PC; unc79-PC; uncoordinated 79, isoform C",
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                "id": "NP_995693",
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        "gene_names_refseq": "ABCC1; CG6214; DmCG6214; Dmel\\CG6214; MRP1; MRP; Mrp1; Mrp; dMRP/CG6214; dMRP1; dMRP; dmrp; lincRNA.123",
        "protein_names_uniprotkb": "ABC-type glutathione-S-conjugate transporter; 7.6.2.3",
        "protein_names_refseq": "CG6214-PI; MRP-PI; Multidrug-Resistance like protein 1, isoform I; Multidrug-Resistance like protein 1; Multidrug-resistance protein; multidrug resistance like protein; multidrug resistance-associated protein; multidrug resistance-like protein 1; multidrug resistance-like protein",
        "tax_id": 7227,
        "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); autosomal dominant nonsyndromic deafness 77 (Disease Ontology:DOID:0112168); primary biliary cholangitis (Disease Ontology:DOID:12236); Dubin-Johnson syndrome (Disease Ontology:DOID:12308); hyperprolactinemia (Disease Ontology:DOID:12700); cholestasis (Disease Ontology:DOID:13580); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); drug-induced hepatitis (Disease Ontology:DOID:2044); bilirubin metabolic disorder (Disease Ontology:DOID:2741); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cholangiocarcinoma (Disease Ontology:DOID:4947); kidney disease (Disease Ontology:DOID:557); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); chronic myeloid leukemia (Disease Ontology:DOID:8552); acute myeloid leukemia (Disease Ontology:DOID:9119); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)",
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                "id": "7.6.2.-",
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            {
                "id": "7.6.2.6",
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                "id": "7.6.2.3",
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        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005774 vacuolar membrane",
        "go_biological_process": "GO:0009636 response to toxic substance;GO:0097254 renal tubular secretion;GO:0098656 monoatomic anion transmembrane transport;GO:0055085 transmembrane transport",
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        ],
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        "length": 978,
        "protein_name": "PH-sensitive chloride channel 1, isoform N",
        "gene_name": "pHCl-1",
        "organism": "Fruit fly",
        "refseq_name": "pH-sensitive chloride channel 1, isoform N",
        "refseq_ac": [
            {
                "id": "NP_001261898",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261898",
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        ],
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        "gene_names_refseq": "BP1024; BcDNA:GH21757; CG12486; CG13444; CG33989; CG44099; CG6112; CT19189; Dmel\\CG44099; pHCL-A; pHCl-1; pHCl",
        "protein_names_uniprotkb": "PH-sensitive chloride channel 1, isoform N",
        "protein_names_refseq": "CG44099-PN; glutamate-gated chloride channel-like; pH-sensitive chloride channel 1, isoform N; pH-sensitive chloride channel; pHCl-1-PN",
        "tax_id": 7227,
        "disease": "hyperekplexia (Disease Ontology:DOID:0060695); hyperekplexia 1 (Disease Ontology:DOID:0060696); syndromic X-linked intellectual disability Pilorge type (Disease Ontology:DOID:0070422)",
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        "function": "Probable transcriptional regulator that is required in neural development for the normal formation of sublateral cholinergic motor neuron processes. Plays a role in regulating the expression of acetylcholine transporter protein unc-17 in the sublateral processes. In particular, it is required in sublateral motor neurons for a left-right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis., [UniProtKB, UniProtKB, UniProtKB]",
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        "disease": "autosomal dominant intellectual developmental disorder 33 (Disease Ontology:DOID:0070063); spinal muscular atrophy (Disease Ontology:DOID:12377); asthma (Disease Ontology:DOID:2841); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908)",
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    },
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            {
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        ],
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            {
                "id": "NP_609406",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609406",
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            }
        ],
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        "protein_names_refseq": "CG6232-PA; loh-PA; lonely heart, isoform A; lonely heart",
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        "disease": "autosomal recessive isolated ectopia lentis 2 (Disease Ontology:DOID:0111149); ectopia lentis with ectopia of pupil (Disease Ontology:DOID:0111648); lens disease (Disease Ontology:DOID:110); thoracic aortic aneurysm (Disease Ontology:DOID:14004); craniosynostosis (Disease Ontology:DOID:2340); asthma (Disease Ontology:DOID:2841)",
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            {
                "id": "NP_608811",
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        "protein_names_uniprotkb": "Centrosomal protein of 97 kDa; Defective transmitter-recycling protein; Dynein axonemal assembly factor 1 homolog; Leucine-rich repeat and IQ domain-containing protein 2; Leucine-rich repeat-containing protein 50 homolog",
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        ],
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                "id": "NP_648447",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648447",
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        "gene_names_refseq": "CG14142; Dmel\\CG14142",
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        "protein_names_refseq": "CG14142-PB; uncharacterized protein, isoform B",
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        "function": "Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
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                "id": "NP_650613",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650613",
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        ],
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        "protein_names_refseq": "CG12548-PD; NompB; no mechanoreceptor potential B, isoform D; nompB-PD",
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            {
                "id": "NP_651674",
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        "protein_names_refseq": "CG6095-PB; Exo84 ortholog; Exo84-PB; exocyst 84, isoform B; onion rings; onion ring",
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        "protein_name": "Eukaryotic translation initiation factor 4H",
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    },
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            {
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    },
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        ],
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        "refseq_name": "uncharacterized protein",
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            {
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                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650624",
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            }
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    },
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        ],
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        "protein_name": "Peptidase A1 domain-containing protein",
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        "organism": "Fruit fly",
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            {
                "id": "NP_650623",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650623",
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            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG5863; CG5863; Dmel_CG5863",
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        "disease": "metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); hypertension (Disease Ontology:DOID:10763); primary biliary cholangitis (Disease Ontology:DOID:12236)",
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        "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity",
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    },
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        ],
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            {
                "id": "NP_650601",
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        "gene_names_uniprotkb": "Dmel\\CG4053; CG4053; Dmel_CG4053; SP185",
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        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0017171 serine hydrolase activity",
        "go_cellular_component": "GO:0005615 extracellular space",
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    },
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        ],
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        "protein_name": "Regulatory protein zeste",
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            {
                "id": "NP_650591",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650591",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "bdwf; CG3995; Dmel\\CG3995; Dmel_CG3995",
        "gene_names_refseq": "CG3995; Dmel\\CG3995; bdwf",
        "protein_names_uniprotkb": "Regulatory protein zeste",
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        "class_list": "",
        "function": "Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter., [UniProtKB, UniProtKB]",
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        "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0043022 ribosome binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0140059 dendrite arborization;GO:0033750 ribosome localization",
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    },
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        ],
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        "protein_name": "Fatty acyl-CoA reductase",
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            {
                "id": "NP_650568",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650568",
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        ],
        "gene_names_uniprotkb": "CT34717; CG14893; Dmel\\CG14893; Dmel_CG14893",
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        "protein_names_refseq": "CG14893-PB; uncharacterized protein",
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        "function": "Catalyzes the reduction of fatty acyl-CoA to fatty alcohols., [UniProtKB, UniProtKB]",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.84",
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        ],
        "go_molecular_function": "GO:0080019 alcohol-forming very long-chain fatty acyl-CoA reductase activity;GO:0102965 alcohol-forming long-chain fatty acyl-CoA reductase activity",
        "go_cellular_component": "GO:0005777 peroxisome;GO:0016020 membrane",
        "go_biological_process": "GO:0035336 long-chain fatty-acyl-CoA metabolic process",
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        ],
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        "protein_name": "Major facilitator superfamily (MFS) profile domain-containing protein",
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        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
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            {
                "id": "NP_650532",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650532",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG17929; CG17929; Dmel_CG17929",
        "gene_names_refseq": "CG17929; Dmel\\CG17929",
        "protein_names_uniprotkb": "Major facilitator superfamily (MFS) profile domain-containing protein",
        "protein_names_refseq": "CG17929-PB; uncharacterized protein",
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        "protein_names_uniprotkb": "V-type proton ATPase 16 kDa proteolipid subunit c; V-type proton ATPase 21 kDa proteolipid subunit c''; Vacuolar proton pump 16 kDa proteolipid subunit c",
        "protein_names_refseq": "CG7026-PB; VhaPPA1-2-PB; vacuolar H[+] ATPase PPA1 subunit 2; vacuolar H[+] ATPase subunit PPA1-2",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG7026)",
        "pathway_count": 1,
        "publication_count": 11,
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        "class_list": "",
        "function": "Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism",
        "go_cellular_component": "GO:0033176 proton-transporting V-type ATPase complex;GO:0016020 membrane;GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain",
        "go_biological_process": "GO:1902600 proton transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9VFE5-1",
        "record_type": "protein",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VFG0-1",
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            {
                "id": "Q9VFG0_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VFG0",
                "type": "external"
            }
        ],
        "mass": 61816.0,
        "length": 560,
        "protein_name": "Major facilitator superfamily (MFS) profile domain-containing protein",
        "gene_name": "Dmel\\CG14857",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_650392",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650392",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG14857; CG14857; Dmel_CG14857",
        "gene_names_refseq": "CG14857; Dmel\\CG14857",
        "protein_names_uniprotkb": "Major facilitator superfamily (MFS) profile domain-containing protein",
        "protein_names_refseq": "CG14857-PA; uncharacterized protein",
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        "disease": "kidney failure (Disease Ontology:DOID:1074); extrahepatic cholestasis (Disease Ontology:DOID:13619); intrahepatic cholestasis (Disease Ontology:DOID:1852); hyperuricemia (Disease Ontology:DOID:1920); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); end stage renal disease (Disease Ontology:DOID:783)",
        "pathway": " (dme:Dmel_CG14857);  (R-DME-112311);  (R-DME-181430);  (R-DME-196807);  (R-DME-200425);  (R-DME-2161517);  (R-DME-442660);  (R-DME-549127);  (R-DME-561048);  (R-DME-917937);  (R-DME-9749641);  (R-DME-9793528)",
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        "go_molecular_function": "GO:0022857 transmembrane transporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
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            {
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        ],
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        "length": 793,
        "protein_name": "pyruvate kinase",
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        ],
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        "protein_names_refseq": "CG7362-PB; uncharacterized protein",
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        "disease": "congenital nonspherocytic hemolytic anemia 2 (Disease Ontology:DOID:0111077); hypertension (Disease Ontology:DOID:10763); malaria (Disease Ontology:DOID:12365)",
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        "organism": "Fruit fly",
        "refseq_name": "Phytanoyl-CoA dioxygenase domain containing 1",
        "refseq_ac": [
            {
                "id": "NP_001097740",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097740",
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            }
        ],
        "gene_names_uniprotkb": "Phyhd1; CG14688; Dmel\\CG14688; Dmel_CG14688; PHYHD1; PHYH",
        "gene_names_refseq": "CG14688; Dmel\\CG14688; PHYHD1; PHYH; Phyhd1",
        "protein_names_uniprotkb": "1.14.11.-; Phytanoyl-CoA dioxygenase domain containing 1",
        "protein_names_refseq": "CG14688-PB; Phyhd1-PB; Phytanoyl-CoA dioxygenase domain containing 1",
        "tax_id": 7227,
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        "pathway": " (dme:Dmel_CG14688)",
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        "go_molecular_function": "GO:0046872 metal ion binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity",
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            {
                "id": "Q9VH32_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VH32",
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        ],
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        "length": 173,
        "protein_name": "Niemann-Pick type C-2d",
        "gene_name": "Npc2d",
        "organism": "Fruit fly",
        "refseq_name": "Niemann-Pick type C-2d",
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            {
                "id": "NP_649975",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649975",
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            }
        ],
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        "gene_names_refseq": "CG12813; Dmel\\CG12813; Npc2d; npc2d",
        "protein_names_uniprotkb": "Niemann-Pick type C-2d",
        "protein_names_refseq": "CG12813-PA; Niemann-Pick type C-2d; Npc2d-PA",
        "tax_id": 7227,
        "disease": "Niemann-Pick disease type C2 (Disease Ontology:DOID:0070114); Niemann-Pick disease (Disease Ontology:DOID:14504)",
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        "go_molecular_function": "GO:0032934 sterol binding",
        "go_cellular_component": "GO:0005576 extracellular region",
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        ],
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        "gene_name": "Dmel\\CG11977",
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        "refseq_name": "uncharacterized protein",
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            {
                "id": "NP_649855",
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        "gene_names_refseq": "CG11977; Dmel\\CG11977",
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        "protein_names_refseq": "CG11977-PB; uncharacterized protein",
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        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription",
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                "id": "Q9VII7_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VII7",
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        ],
        "mass": 41687.0,
        "length": 372,
        "protein_name": "Serpin 38F, isoform A",
        "gene_name": "Spn38F",
        "organism": "Fruit fly",
        "refseq_name": "serpin 38F, isoform A",
        "refseq_ac": [
            {
                "id": "NP_524956",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524956",
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        ],
        "gene_names_uniprotkb": "Spn38F; CG9334; Dmel\\CG9334; Dmel_CG9334; Sp3; Spn3; sp3",
        "gene_names_refseq": "CG9334; Dmel\\CG9334; Sp3; Spn38F; Spn3; sp3",
        "protein_names_uniprotkb": "Serpin 38F, isoform A",
        "protein_names_refseq": "CG9334-PA; Spn38F-PA; serine protease inhibitor 3; serpin 38F, isoform A; serpin 3",
        "tax_id": 7227,
        "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); coarctation of the aorta (Disease Ontology:DOID:0051054); stroke (Disease Ontology:DOID:0051061); chemical colitis (Disease Ontology:DOID:0060186); ileitis (Disease Ontology:DOID:0060189); atrial fibrillation (Disease Ontology:DOID:0060224); thrombosis (Disease Ontology:DOID:0060903); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); Nagashima-type palmoplantar keratosis (Disease Ontology:DOID:0070555); polycystic kidney disease (Disease Ontology:DOID:0080322); corticosteroid-binding globulin deficiency (Disease Ontology:DOID:0090030); osteonecrosis (Disease Ontology:DOID:10159); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); nephritis (Disease Ontology:DOID:10952); meconium aspiration syndrome (Disease Ontology:DOID:11049); hydronephrosis (Disease Ontology:DOID:11111); IgA vasculitis (Disease Ontology:DOID:11123); disseminated intravascular coagulation (Disease Ontology:DOID:11247); adult respiratory distress syndrome (Disease Ontology:DOID:11394); pulmonary edema (Disease Ontology:DOID:11396); sciatic neuropathy (Disease Ontology:DOID:11446); prediabetes syndrome (Disease Ontology:DOID:11716); nephrotic syndrome (Disease Ontology:DOID:1184); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); allergic disease (Disease Ontology:DOID:1205); otosclerosis (Disease Ontology:DOID:12185); primary biliary cholangitis (Disease Ontology:DOID:12236); alcoholic hepatitis (Disease Ontology:DOID:12351); dilated cardiomyopathy (Disease Ontology:DOID:12930); retinopathy of prematurity (Disease Ontology:DOID:13025); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); uveitis (Disease Ontology:DOID:13141); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372); sick sinus syndrome (Disease Ontology:DOID:13884); toxic shock syndrome (Disease Ontology:DOID:14115); Fabry disease (Disease Ontology:DOID:14499); cystic fibrosis (Disease Ontology:DOID:1485); diffuse scleroderma (Disease Ontology:DOID:1580); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); atherosclerosis (Disease Ontology:DOID:1936); hyperinsulinism (Disease Ontology:DOID:2018); transient cerebral ischemia (Disease Ontology:DOID:224); arteriosclerosis (Disease Ontology:DOID:2349); multiple sclerosis (Disease Ontology:DOID:2377); central retinal vein occlusion (Disease Ontology:DOID:2450); endometriosis (Disease Ontology:DOID:289); acute pancreatitis (Disease Ontology:DOID:2913); glomerulonephritis (Disease Ontology:DOID:2921); severe acute respiratory syndrome (Disease Ontology:DOID:2945); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); temporal lobe epilepsy (Disease Ontology:DOID:3328); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); antithrombin III deficiency (Disease Ontology:DOID:3755); pulmonary fibrosis (Disease Ontology:DOID:3770); lung adenocarcinoma (Disease Ontology:DOID:3910); liver disease (Disease Ontology:DOID:409); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); cerebrovascular disease (Disease Ontology:DOID:6713); osteoarthritis (Disease Ontology:DOID:8398); chronic myeloid leukemia (Disease Ontology:DOID:8552); vasculitis (Disease Ontology:DOID:865); intermediate coronary syndrome (Disease Ontology:DOID:8805); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675); mitral valve prolapse (Disease Ontology:DOID:988); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (dme:Dmel_CG9334);  (R-DME-114608);  (R-DME-194002);  (R-DME-2022377);  (R-DME-204005);  (R-DME-381426);  (R-DME-5694530);  (R-DME-6798695);  (R-DME-8957275);  (R-DME-9757110);  (R-DME-9769739)",
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        "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0007320 insemination;GO:0050829 defense response to Gram-negative bacterium;GO:0045861 negative regulation of proteolysis;GO:0007618 mating",
        "synthesized_glycan_count": 0,
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    {
        "uniprot_canonical_ac": "Q9VIJ1-1",
        "uniprot_id": [
            {
                "id": "Q9VIJ1_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VIJ1",
                "type": "external"
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        ],
        "mass": 22652.0,
        "length": 198,
        "protein_name": "Chemosensory protein B 38c",
        "gene_name": "CheB38c",
        "organism": "Fruit fly",
        "refseq_name": "chemosensory protein B 38c",
        "refseq_ac": [
            {
                "id": "NP_610061",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610061",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CheB38c; CG14405; Dmel\\CG14405; Dmel_CG14405",
        "gene_names_refseq": "CG14405; CheB38c; Dmel\\CG14405",
        "protein_names_uniprotkb": "Chemosensory protein B 38c",
        "protein_names_refseq": "CG14405-PA; CheB38c-PA; chemosensory protein B 38c",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG14405)",
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        "disease": "aspiration pneumonia (Disease Ontology:DOID:0050152); obstructive sleep apnea (Disease Ontology:DOID:0050848); renal fibrosis (Disease Ontology:DOID:0050855); non-arteritic anterior ischemic optic neuropathy (Disease Ontology:DOID:0050864); stroke (Disease Ontology:DOID:0051061); atrial fibrillation (Disease Ontology:DOID:0060224); alcohol-associated liver disease (Disease Ontology:DOID:0070658); Coronavirus infectious disease (Disease Ontology:DOID:0080599); COVID-19 (Disease Ontology:DOID:0080600); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); nephritis (Disease Ontology:DOID:10952); IgA vasculitis (Disease Ontology:DOID:11123); sarcoidosis (Disease Ontology:DOID:11335); pyelonephritis (Disease Ontology:DOID:11400); diabetic angiopathy (Disease Ontology:DOID:11713); allergic disease (Disease Ontology:DOID:1205); leukemia (Disease Ontology:DOID:1240); hepatitis A (Disease Ontology:DOID:12549); uveitis (Disease Ontology:DOID:13141); lung cancer (Disease Ontology:DOID:1324); Behcet's disease (Disease Ontology:DOID:13241); toxic shock syndrome (Disease Ontology:DOID:14115); Fabry disease (Disease Ontology:DOID:14499); breast cancer (Disease Ontology:DOID:1612); anemia (Disease Ontology:DOID:2355); asthma (Disease Ontology:DOID:2841); IgA glomerulonephritis (Disease Ontology:DOID:2986); familial Mediterranean fever (Disease Ontology:DOID:2987); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); gallbladder adenocarcinoma (Disease Ontology:DOID:3500); cerebral infarction (Disease Ontology:DOID:3526); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung carcinoma (Disease Ontology:DOID:3905); heart valve disease (Disease Ontology:DOID:4079); systemic scleroderma (Disease Ontology:DOID:418); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); pneumonia (Disease Ontology:DOID:552); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); mitral valve disease (Disease Ontology:DOID:61); hepatocellular carcinoma (Disease Ontology:DOID:684); ankylosing spondylitis (Disease Ontology:DOID:7147); end stage renal disease (Disease Ontology:DOID:783); extrinsic allergic alveolitis (Disease Ontology:DOID:841); polycythemia (Disease Ontology:DOID:8432); chronic myeloid leukemia (Disease Ontology:DOID:8552); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); subacute sclerosing panencephalitis (Disease Ontology:DOID:8970); type 2 diabetes mellitus (Disease Ontology:DOID:9352); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744); diastolic heart failure (Disease Ontology:DOID:9775); mitral valve prolapse (Disease Ontology:DOID:988)",
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            }
        ],
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        "gene_names_refseq": "CG14925; Dmel\\CG14925; Osi21; die4; diehard4",
        "protein_names_uniprotkb": "Osiris 21",
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    },
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        ],
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            {
                "id": "NP_001033898",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033898",
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            }
        ],
        "gene_names_uniprotkb": "CG31722; CG17139; CG31722-A; Dmel\\CG17139; Dmel_CG17139",
        "gene_names_refseq": "CG17139; CG31722-A; CG31722; Dmel\\CG17139",
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        "protein_names_refseq": "CG17139-PA; uncharacterized protein",
        "tax_id": 7227,
        "disease": "Parkinsonism (Disease Ontology:DOID:0080855); prostate cancer (Disease Ontology:DOID:10283); Parkinson's disease (Disease Ontology:DOID:14330); temporal lobe epilepsy (Disease Ontology:DOID:3328); myocardial infarction (Disease Ontology:DOID:5844)",
        "pathway": " (dme:Dmel_CG17139);  (R-DME-5205685);  (R-DME-5689880);  (R-DME-70268)",
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    },
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        ],
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        "protein_name": "cathepsin L",
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            {
                "id": "NP_609387",
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            }
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        "gene_names_uniprotkb": "CtsL4; CG5367; CTS L; Cts10; Dmel\\CG5367; Dmel_CG5367",
        "gene_names_refseq": "CG5367; CTS L; Cts10; CtsL4; Dmel\\CG5367",
        "protein_names_uniprotkb": "cathepsin L; 3.4.22.15",
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        "tax_id": 7227,
        "disease": "COVID-19 (Disease Ontology:DOID:0080600); otitis media (Disease Ontology:DOID:10754); nephrotic syndrome (Disease Ontology:DOID:1184); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); brain ischemia (Disease Ontology:DOID:2316); pancreatitis (Disease Ontology:DOID:4989); hepatocellular carcinoma (Disease Ontology:DOID:684); muscular atrophy (Disease Ontology:DOID:767); hyperthyroidism (Disease Ontology:DOID:7998); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (dme:Dmel_CG5367);  (R-DME-1442490);  (R-DME-1474228);  (R-DME-2022090);  (R-DME-2024096);  (R-DME-2132295);  (R-DME-8939242)",
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                "id": "3.4.24.-",
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                "id": "3.4.22.15",
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            {
                "id": "3.4.23.-",
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                "id": "3.4.22.41",
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            {
                "id": "3.4.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-",
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            {
                "id": "3.4.22.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-",
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            }
        ],
        "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome",
        "go_biological_process": "GO:0051603 proteolysis involved in protein catabolic process",
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        ],
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                "id": "NP_609350",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609350",
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        "disease": "triple-A syndrome (Disease Ontology:DOID:0050602); achalasia (Disease Ontology:DOID:9164)",
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        "protein_names_refseq": "CG13131-PA; uncharacterized protein",
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                "id": "PEO1_DROME",
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        "refseq_name": "mitochondrial DNA helicase",
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            {
                "id": "NP_609318",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609318",
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        "protein_names_uniprotkb": "Mitochondrial DNA helicase; 5.6.2.3; Twinkle mtDNA helicase; Twinkle protein, mitochondrial",
        "protein_names_refseq": "CG5924-PA; d-mtDNA helicase; mitochondrial DNA helicase; mtDNA-helicase-PA; twinkle helicase",
        "tax_id": 7227,
        "disease": "Perrault syndrome (Disease Ontology:DOID:0050857); mitochondrial DNA depletion syndrome (Disease Ontology:DOID:0070329); mitochondrial DNA depletion syndrome 7 (Disease Ontology:DOID:0080126); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5 (Disease Ontology:DOID:0111518); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 3 (Disease Ontology:DOID:0111520); chronic progressive external ophthalmoplegia (Disease Ontology:DOID:12558); Parkinson's disease (Disease Ontology:DOID:14330)",
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        "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); familial encephalopathy with neuroserpin inclusion bodies (Disease Ontology:DOID:0050831); coarctation of the aorta (Disease Ontology:DOID:0051054); stroke (Disease Ontology:DOID:0051061); chemical colitis (Disease Ontology:DOID:0060186); ileitis (Disease Ontology:DOID:0060189); atrial fibrillation (Disease Ontology:DOID:0060224); thrombosis (Disease Ontology:DOID:0060903); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); Nagashima-type palmoplantar keratosis (Disease Ontology:DOID:0070555); polycystic kidney disease (Disease Ontology:DOID:0080322); corticosteroid-binding globulin deficiency (Disease Ontology:DOID:0090030); osteonecrosis (Disease Ontology:DOID:10159); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); nephritis (Disease Ontology:DOID:10952); meconium aspiration syndrome (Disease Ontology:DOID:11049); hydronephrosis (Disease Ontology:DOID:11111); IgA vasculitis (Disease Ontology:DOID:11123); disseminated intravascular coagulation (Disease Ontology:DOID:11247); adult respiratory distress syndrome (Disease Ontology:DOID:11394); pulmonary edema (Disease Ontology:DOID:11396); sciatic neuropathy (Disease Ontology:DOID:11446); prediabetes syndrome (Disease Ontology:DOID:11716); nephrotic syndrome (Disease Ontology:DOID:1184); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); allergic disease (Disease Ontology:DOID:1205); otosclerosis (Disease Ontology:DOID:12185); primary biliary cholangitis (Disease Ontology:DOID:12236); alcoholic hepatitis (Disease Ontology:DOID:12351); dilated cardiomyopathy (Disease Ontology:DOID:12930); retinopathy of prematurity (Disease Ontology:DOID:13025); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); uveitis (Disease Ontology:DOID:13141); alpha 1-antitrypsin deficiency (Disease Ontology:DOID:13372); sick sinus syndrome (Disease Ontology:DOID:13884); toxic shock syndrome (Disease Ontology:DOID:14115); Fabry disease (Disease Ontology:DOID:14499); cystic fibrosis (Disease Ontology:DOID:1485); diffuse scleroderma (Disease Ontology:DOID:1580); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); atherosclerosis (Disease Ontology:DOID:1936); hyperinsulinism (Disease Ontology:DOID:2018); transient cerebral ischemia (Disease Ontology:DOID:224); arteriosclerosis (Disease Ontology:DOID:2349); multiple sclerosis (Disease Ontology:DOID:2377); central retinal vein occlusion (Disease Ontology:DOID:2450); endometriosis (Disease Ontology:DOID:289); acute pancreatitis (Disease Ontology:DOID:2913); glomerulonephritis (Disease Ontology:DOID:2921); severe acute respiratory syndrome (Disease Ontology:DOID:2945); IgA glomerulonephritis (Disease Ontology:DOID:2986); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); temporal lobe epilepsy (Disease Ontology:DOID:3328); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); middle cerebral artery infarction (Disease Ontology:DOID:3525); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); antithrombin III deficiency (Disease Ontology:DOID:3755); pulmonary fibrosis (Disease Ontology:DOID:3770); lung adenocarcinoma (Disease Ontology:DOID:3910); liver disease (Disease Ontology:DOID:409); systemic scleroderma (Disease Ontology:DOID:418); macular degeneration (Disease Ontology:DOID:4448); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); cerebrovascular disease (Disease Ontology:DOID:6713); osteoarthritis (Disease Ontology:DOID:8398); chronic myeloid leukemia (Disease Ontology:DOID:8552); vasculitis (Disease Ontology:DOID:865); intermediate coronary syndrome (Disease Ontology:DOID:8805); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675); mitral valve prolapse (Disease Ontology:DOID:988); obesity (Disease Ontology:DOID:9970)",
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        "tax_id": 7227,
        "disease": "pseudohypoparathyroidism type 1B (Disease Ontology:DOID:0080222)",
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        "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); silicosis (Disease Ontology:DOID:10325); allergic disease (Disease Ontology:DOID:1205); dysostosis (Disease Ontology:DOID:1934); asthma (Disease Ontology:DOID:2841)",
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        "function": "Plus-end directed microtubule motor that may be used for anterograde axonal transport and could conceivably move cargos in fly neurons different than those moved by kinesin heavy chain or other plus-end directed motors., [UniProtKB, UniProtKB]",
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        "protein_name": "Lethal (3) persistent salivary gland 2",
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        "organism": "Fruit fly",
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        "protein_names_uniprotkb": "Lethal (3) persistent salivary gland 2",
        "protein_names_refseq": "CG5146-PA; l(3)psg2-PA; lethal (3) persistent salivary gland 2",
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        "length": 950,
        "protein_name": "Sodium/calcium exchanger Calx",
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        "tax_id": 7227,
        "disease": "atrial fibrillation (Disease Ontology:DOID:0060224); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432)",
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        "class_list": "",
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            }
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        "gene_names_refseq": "CG18340; DmUCP4B; Dmel\\CG18340; UCP4B; Ucp 4b; Ucp4B; Ucp4b; dmUCP4b; ucp4B",
        "protein_names_uniprotkb": "Uncoupling protein 4B, isoform A",
        "protein_names_refseq": "CG18340-PA; Ucp4B-PA; uncoupling protein 4B, isoform A; uncoupling protein 4b",
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        "gene_names_refseq": "CG14207; Dmel21.3; Dmel\\CG14207; Hsp20-like protein; Hsp20; HspB8; dHspB8",
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        "pathway": " (dme:Dmel_CG14207);  (R-DME-3371571);  (R-DME-4420097);  (R-DME-450408);  (R-DME-9009391)",
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                "id": "NP_001260462",
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        "protein_name": "Shaven, isoform A",
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                "id": "NP_524633",
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        "gene_names_refseq": "CG11049; Cat; D-Pax2; D-pax-2; D-pax2; DPax-2; DPax2; Dmel\\CG11049; Dpax-2; Dpax2; PAX2; Pax2/5/8; Pax258; Pax2; Sv; d-Pax2; dPax258; dPax2; en(lz)4G/I; l(4)40; pax2/sparkling; pol; shaven/sparkling; spa-sv; spa; sv",
        "protein_names_uniprotkb": "Shaven, isoform A",
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        "go_cellular_component": "GO:0005634 nucleus",
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        "go_biological_process": "GO:0006629 lipid metabolic process;GO:0071456 cellular response to hypoxia;GO:0010468 regulation of gene expression;GO:0030706 germarium-derived oocyte differentiation;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
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    },
    {
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            {
                "id": "Q9VHY2_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VHY2",
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            }
        ],
        "mass": 108598.0,
        "length": 945,
        "protein_name": "Transcription termination factor 2",
        "gene_name": "Dmel\\CG10445",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform D",
        "refseq_ac": [
            {
                "id": "NP_001246974",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246974",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG10445; CG10445; Dmel_CG10445",
        "gene_names_refseq": "CG10445; Dmel\\CG10445",
        "protein_names_uniprotkb": "Transcription termination factor 2",
        "protein_names_refseq": "CG10445-PD; uncharacterized protein, isoform D",
        "tax_id": 7227,
        "disease": "gastrointestinal system cancer (Disease Ontology:DOID:3119)",
        "pathway": " (dme:Dmel_CG10445)",
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        "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0016887 ATP hydrolysis activity;GO:0008094 ATP-dependent activity, acting on DNA;GO:0140658 ATP-dependent chromatin remodeler activity",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0000381 regulation of alternative mRNA splicing, via spliceosome;GO:0006281 DNA repair",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9V9S4-1",
        "uniprot_id": [
            {
                "id": "Q9V9S4_DROME",
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            }
        ],
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        "length": 492,
        "protein_name": "Putative inorganic phosphate cotransporter",
        "gene_name": "Dmel\\CG2003",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform A",
        "refseq_ac": [
            {
                "id": "NP_651903",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651903",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG2003; CG2003; Dmel_CG2003",
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        "protein_names_uniprotkb": "Putative inorganic phosphate cotransporter",
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        "disease": "",
        "pathway": " (dme:Dmel_CG2003);  (R-DME-2672351);  (R-DME-427652)",
        "pathway_count": 3,
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        "class_list": "",
        "function": "May be an inorganic phosphate cotransporter., [UniProtKB, UniProtKB]",
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        "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015293 symporter activity",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "GO:0006814 sodium ion transport",
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        "hit_score": 1.2,
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    },
    {
        "uniprot_canonical_ac": "Q8IQT0-1",
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            {
                "id": "Q8IQT0_DROME",
                "url": "https://www.uniprot.org/uniprot/Q8IQT0",
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            }
        ],
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        "length": 195,
        "protein_name": "Gamma-glutamylcyclotransferase",
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        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform B",
        "refseq_ac": [
            {
                "id": "NP_730334",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_730334",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG32196; CG32196; Dmel_CG32196",
        "gene_names_refseq": "CG32196; Dmel\\CG32196",
        "protein_names_uniprotkb": "Gamma-glutamylcyclotransferase; 4.3.2.9",
        "protein_names_refseq": "CG32196-PB; uncharacterized protein, isoform B",
        "tax_id": 7227,
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        "pathway": " (dme:Dmel_CG32196);  (R-DME-174403)",
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        "class_list": "",
        "function": "Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis., [UniProtKB, UniProtKB]",
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            {
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            }
        ],
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    },
    {
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            }
        ],
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        "protein_name": "Ras-related protein Rab-21",
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            {
                "id": "NP_001036321",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036321",
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            }
        ],
        "gene_names_uniprotkb": "Rab21; AAF45341; CG17515; CG40304; DmRab21; Dmel\\CG17515; Dmel_CG17515; Q7PLE8; Rab-21; anon-EST:Posey237; rab21",
        "gene_names_refseq": "AAF45341; CG17515; CG40304; DmRab21; Dmel\\CG17515; Q7PLE8; Rab-21; Rab21; anon-EST:Posey237; rab21",
        "protein_names_uniprotkb": "Ras-related protein Rab-21",
        "protein_names_refseq": "CG17515-PC; Rab21, isoform C; Rab21-PC",
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        "pathway": " (dme:Dmel_CG17515);  (R-DME-8873719);  (R-DME-8876198)",
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        "go_biological_process": "GO:1901098 positive regulation of autophagosome maturation;GO:0016192 vesicle-mediated transport;GO:0030866 cortical actin cytoskeleton organization;GO:0032482 Rab protein signal transduction;GO:0006886 intracellular protein transport",
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        ],
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        "protein_name": "Uncharacterized protein",
        "gene_name": "Dmel\\CG32686; anon-WO02059370.11",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform B",
        "refseq_ac": [
            {
                "id": "NP_727413",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_727413",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG32686; anon-WO02059370.11; BcDNA:AT25933; CG32686; Dmel\\CG32686; Dmel_CG32686; anon-WO02059370.11",
        "gene_names_refseq": "BcDNA:AT25933; CG32686; Dmel\\CG32686; anon-WO02059370.11",
        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG32686-PB; uncharacterized protein, isoform B",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG32686)",
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        "record_id": "Q8IRL2-1",
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    {
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            {
                "id": "Q8IRL9_DROME",
                "url": "https://www.uniprot.org/uniprot/Q8IRL9",
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            }
        ],
        "mass": 124589.0,
        "length": 1100,
        "protein_name": "DNA replication ATP-dependent helicase/nuclease",
        "gene_name": "Dna2",
        "organism": "Fruit fly",
        "refseq_name": "DNA replication helicase/nuclease 2, isoform B",
        "refseq_ac": [
            {
                "id": "NP_727386",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_727386",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dna2; CG2990; DNA2; DmDNA2; Dmel\\CG2990; Dmel_CG2990; l(1)19-65; l(1)9Aa; mus(1)107; mus(1)109; mus-109; mus107; mus109",
        "gene_names_refseq": "CG2990; DNA2; DmDNA2; Dmel\\CG2990; Dna2; l(1)19-65; l(1)9Aa; mus(1)107; mus(1)109; mus-109; mus107; mus109",
        "protein_names_uniprotkb": "DNA replication ATP-dependent helicase/nuclease; 3.1.-.-; 3.6.4.12",
        "protein_names_refseq": "CG2990-PB; DNA helicase; DNA replication helicase/nuclease 2, isoform B; Dna2-PB; mutagen-sensitive 109",
        "tax_id": 7227,
        "disease": "Seckel syndrome (Disease Ontology:DOID:0050569); isolated growth hormone deficiency type IA (Disease Ontology:DOID:0060873); Seckel syndrome 8 (Disease Ontology:DOID:0070009); autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 6 (Disease Ontology:DOID:0111519); cancer (Disease Ontology:DOID:162); Bloom syndrome (Disease Ontology:DOID:2717); Werner syndrome (Disease Ontology:DOID:5688); mitochondrial myopathy (Disease Ontology:DOID:699)",
        "pathway": " (dme:Dmel_CG2990);  (R-DME-69166)",
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        "class_list": "",
        "function": "Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA., [UniProtKB, UniProtKB, UniProtKB]",
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            {
                "id": "NP_610388",
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            }
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            {
                "id": "A1Z6L9_DROME",
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            {
                "id": "NP_001260726",
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        "protein_names_uniprotkb": "Heat shock protein 75 kDa, mitochondrial; TNFR-associated protein 1; Tumor necrosis factor type 1 receptor-associated protein",
        "protein_names_refseq": "CG3152-PB; Hsp90-related protein; TNF receptor-associated protein 1; Trap1, isoform B; Trap1-PB",
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        "go_biological_process": "GO:0006979 response to oxidative stress;GO:0034605 cellular response to heat;GO:1902884 positive regulation of response to oxidative stress;GO:0006457 protein folding;GO:0009408 response to heat",
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    },
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            {
                "id": "B7YZJ4_DROME",
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        ],
        "mass": 47167.0,
        "length": 418,
        "protein_name": "Ataxin-10",
        "gene_name": "Atxn10",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform E",
        "refseq_ac": [
            {
                "id": "NP_001137693",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137693",
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            }
        ],
        "gene_names_uniprotkb": "Atxn10; CG4975; Dmel\\CG4975; Dmel_CG4975",
        "gene_names_refseq": "Atxn10; CG4975; Dmel\\CG4975",
        "protein_names_uniprotkb": "Ataxin-10",
        "protein_names_refseq": "CG4975-PE; uncharacterized protein, isoform E",
        "tax_id": 7227,
        "disease": "spinocerebellar ataxia 10 (Disease Ontology:DOID:0050960)",
        "pathway": " (dme:Dmel_CG4975)",
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        "class_list": "",
        "function": "May play a role in the regulation of cytokinesis. May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons. Does not appear to play a major role in ciliogenesis., [UniProtKB, UniProtKB]",
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        "go_cellular_component": "GO:0005829 cytosol;GO:0035869 ciliary transition zone",
        "go_biological_process": "GO:0031175 neuron projection development;GO:0051301 cell division;GO:0060271 cilium assembly",
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        "protein_name": "VWFC domain-containing protein",
        "gene_name": "CG18499",
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        "refseq_name": "uncharacterized protein, isoform C",
        "refseq_ac": [
            {
                "id": "NP_001137815",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137815",
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            }
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        "gene_names_uniprotkb": "CG18499; CG17130; CG31869; Dmel\\CG31869; Dmel_CG31869",
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        "protein_names_uniprotkb": "VWFC domain-containing protein",
        "protein_names_refseq": "CG31869-PC; uncharacterized protein, isoform C",
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        "pathway": " (dme:Dmel_CG31869)",
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        "length": 61,
        "protein_name": "Ubiquinol-cytochrome c reductase complex assembly factor 6",
        "gene_name": "sloth2",
        "organism": "Fruit fly",
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            {
                "id": "NP_001138171",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138171",
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        "protein_names_refseq": "CG42308-PA; sloth 2, isoform A; sloth2-PA",
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        "function": "Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation., [UniProtKB, PubMed]",
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        "protein_name": "Dpr-interacting protein beta, isoform C; Dpr-interacting protein beta, isoform F",
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        "refseq_name": "Dpr-interacting protein beta, isoform C",
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            {
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                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138225",
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        "gene_names_uniprotkb": "DIP-beta; 42343; BP1062; BcDNA:RE23430; CG12564; CG12565; CG14583; CG34019; CG42343; CT34319; DIPbeta; Dmel\\CG42343; Dmel_CG42343; pp-CT34319; pp-CT34320; pp-CT34321",
        "gene_names_refseq": "42343; BP1062; BcDNA:RE23430; CG12564; CG12565; CG14583; CG34019; CG42343; CT34319; DIP-beta; DIPbeta; Dmel\\CG42343; pp-CT34319; pp-CT34320; pp-CT34321",
        "protein_names_uniprotkb": "Dpr-interacting protein beta, isoform C; Dpr-interacting protein beta, isoform F",
        "protein_names_refseq": "CG42343-PC; DIP-beta-PC; Dpr-interacting protein beta, isoform C",
        "tax_id": 7227,
        "disease": "primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); uterine fibroid (Disease Ontology:DOID:13223); ovary epithelial cancer (Disease Ontology:DOID:2152); ovarian cancer (Disease Ontology:DOID:2394); congestive heart failure (Disease Ontology:DOID:6000)",
        "pathway": " (dme:Dmel_CG42343);  (R-DME-1474228);  (R-DME-1971475);  (R-DME-2022928);  (R-DME-2024096);  (R-DME-216083);  (R-DME-3000171);  (R-DME-3000178);  (R-DME-375165);  (R-DME-419037);  (R-DME-445144);  (R-DME-5673001);  (R-DME-9769739);  (R-DME-9913351)",
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        "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection",
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    {
        "uniprot_canonical_ac": "D5SHR0-1",
        "uniprot_id": [
            {
                "id": "TIWAZ_DROME",
                "url": "https://www.uniprot.org/uniprot/D5SHR0",
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        ],
        "mass": 40146.0,
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        "protein_name": "BTB/POZ domain-containing protein Tiwaz",
        "gene_name": "twz",
        "organism": "Fruit fly",
        "refseq_name": "tiwaz, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001246449",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246449",
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        ],
        "gene_names_uniprotkb": "twz; CG10440",
        "gene_names_refseq": "CG10440; Dmel\\CG10440; Twz; twz",
        "protein_names_uniprotkb": "BTB/POZ domain-containing protein Tiwaz; Potassium channel tetramerization domain-containing protein Tiwaz",
        "protein_names_refseq": "CG10440-PB; tiwaz, isoform B; tiwaz; twz-PB",
        "tax_id": 7227,
        "disease": "scalp-ear-nipple syndrome (Disease Ontology:DOID:0111550)",
        "pathway": " (dme:Dmel_CG10440);  (R-DME-8866904)",
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        "function": "Functions with the transcription factor TfAP-2 to regulate octopamine neuronal signaling pathways that control behaviors such as male aggression, male mating, and the initiation of feeding (PubMed:24142897, PubMed:25187989, PubMed:30231996). Required for TfAP-2 transcriptional activity in octopaminergic neurons (PubMed:24142897, PubMed:25187989). Functions with TfAP-2 to regulate expression of genes which are involved in promoting octopamine production and secretion from octopaminergic neurons, such as Tbh and Vmat (PubMed:24142897, PubMed:25187989). Octopamine then modulates feeding and male aggression by regulating the expression of the satiation hormone Dsk in insulin-producing cells (IPCs) (PubMed:24142897, PubMed:25187989). Functions with octopamine and Dsk as part of a negative feedback loop to prevent overeating; acts with TfAP-2 to regulate octopamine signaling pathways that initiate feeding, then octopamine activates expression of Dsk which inhibits consummatory behavior (PubMed:25187989). May also be involved in negatively regulating nociception in larvae to prevent spontaneous pain and hyperalgesia (PubMed:30231996)., [UniProtKB, PubMed, PubMed, PubMed]",
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        "go_molecular_function": "GO:0003714 transcription corepressor activity",
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        "go_biological_process": "GO:0008049 male courtship behavior;GO:0002121 inter-male aggressive behavior;GO:0008344 adult locomotory behavior;GO:0051260 protein homooligomerization;GO:0045892 negative regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
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        "gene_name": "Dmel\\CG42497",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
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                "id": "NP_001163242",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163242",
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        ],
        "gene_names_uniprotkb": "Dmel\\CG42497; CG42497; Dmel_CG42497",
        "gene_names_refseq": "CG42497; Dmel\\CG42497; Dromel_CG9878_FBtr0071676_tim10_uORF",
        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG42497-PA; CPuORF of FBgn0027360; uncharacterized protein",
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            {
                "id": "Q7KTZ2_DROME",
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            }
        ],
        "mass": 56286.0,
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        "protein_name": "Pi3K21B, isoform B; Pi3K21B, isoform E",
        "gene_name": "Pi3K21B",
        "organism": "Fruit fly",
        "refseq_name": "Pi3K21B, isoform E",
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            {
                "id": "NP_001259817",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259817",
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            }
        ],
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        "protein_names_refseq": "CG2699-PE; PI 3-kinase; PI3 kinase; PI3-kinase; Pi3K21B, isoform E; Pi3K21B-PE; dPI 3-kinase",
        "tax_id": 7227,
        "disease": "agammaglobulinemia 7 (Disease Ontology:DOID:0081139); SHORT syndrome (Disease Ontology:DOID:0111454); immunodeficiency 36 (Disease Ontology:DOID:0111949); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); endometrial cancer (Disease Ontology:DOID:1380); X-linked agammaglobulinemia (Disease Ontology:DOID:14179); colon cancer (Disease Ontology:DOID:219); colon adenocarcinoma (Disease Ontology:DOID:234); endometrial adenocarcinoma (Disease Ontology:DOID:2870); endometrial carcinoma (Disease Ontology:DOID:2871); high grade glioma (Disease Ontology:DOID:3070); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); lung adenocarcinoma (Disease Ontology:DOID:3910); renal cell carcinoma (Disease Ontology:DOID:4450); lung small cell carcinoma (Disease Ontology:DOID:5409); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); astroblastoma (Disease Ontology:DOID:7305); osteoarthritis (Disease Ontology:DOID:8398); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)",
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        "go_molecular_function": "GO:0043023 ribosomal large subunit binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0000055 ribosomal large subunit export from nucleus;GO:0015031 protein transport",
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        "hit_score": 1.2,
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    },
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        "uniprot_canonical_ac": "O46085-1",
        "uniprot_id": [
            {
                "id": "O46085_DROME",
                "url": "https://www.uniprot.org/uniprot/O46085",
                "type": "external"
            }
        ],
        "mass": 69361.0,
        "length": 614,
        "protein_name": "Peroxisomal targeting signal 1 receptor",
        "gene_name": "Pex5",
        "organism": "Fruit fly",
        "refseq_name": "peroxin 5, isoform A",
        "refseq_ac": [
            {
                "id": "NP_726771",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_726771",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Pex5; CG14815; DmelPex5; Dmel\\CG14815; Dmel_CG14815; EG:63B12.5; PEX5",
        "gene_names_refseq": "CG14815; DmelPex5; Dmel\\CG14815; EG:63B12.5; PEX5; Pex5",
        "protein_names_uniprotkb": "Peroxisomal targeting signal 1 receptor; PTS1-BP; Peroxin-5",
        "protein_names_refseq": "CG14815-PA; Pex5-PA; peroxin 5, isoform A",
        "tax_id": 7227,
        "disease": "peroxisomal biogenesis disorder (Disease Ontology:DOID:0080377); peroxisome biogenesis disorder 2A (Disease Ontology:DOID:0080477); peroxisome biogenesis disorder 2B (Disease Ontology:DOID:0080622); rhizomelic chondrodysplasia punctata type 5 (Disease Ontology:DOID:0110854)",
        "pathway": " (dme:Dmel_CG14815);  (R-DME-8866654);  (R-DME-9033241);  (R-DME-9664873)",
        "pathway_count": 4,
        "publication_count": 11,
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        "class_list": "",
        "function": "In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7. Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal. PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5., [UniProtKB, UniProtKB, UniProtKB]; Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle., [UniProtKB, UniProtKB, UniProtKB]",
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        "go_molecular_function": "GO:0005052 peroxisome matrix targeting signal-1 binding",
        "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005782 peroxisomal matrix;GO:0005829 cytosol",
        "go_biological_process": "GO:0007031 peroxisome organization;GO:0016558 protein import into peroxisome matrix;GO:0016560 protein import into peroxisome matrix, docking;GO:0072347 response to anesthetic;GO:0015031 protein transport",
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        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform C",
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            {
                "id": "NP_001284772",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284772",
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            }
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        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG11409-PC; uncharacterized protein, isoform C",
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            {
                "id": "NP_569906",
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                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EG:8D8.4; CG11417; Dmel\\CG11417; Dmel_CG11417",
        "gene_names_refseq": "CG11417; Dmel\\CG11417; EG:8D8.4",
        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG11417-PA; uncharacterized protein",
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        "protein_name": "Adaptor protein complex 2, mu subunit, isoform A; Adaptor protein complex 2, mu subunit, isoform B; Adaptor protein complex 2, mu subunit, isoform C",
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        "refseq_name": "adaptor protein complex 2, mu subunit, isoform C",
        "refseq_ac": [
            {
                "id": "NP_001163686",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163686",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "AP-2mu; AP-50; AP2mu2; AP50; CG7057; Dmel\\CG7057; Dmel_CG7057; Dmu2; MENE (3R)-D; MENE(3R)-D; anon-EST:Posey50; anon-WO0172774.104; apm4; cg7057; mu2-ada; mu2",
        "gene_names_refseq": "AP-2mu; AP-50; AP2mu2; AP50; CG7057; Dmel\\CG7057; Dmu2; MENE (3R)-D; MENE(3R)-D; anon-EST:Posey50; anon-WO0172774.104; apm4; cg7057; mu2-ada; mu2",
        "protein_names_uniprotkb": "Adaptor protein complex 2, mu subunit, isoform A; Adaptor protein complex 2, mu subunit, isoform B; Adaptor protein complex 2, mu subunit, isoform C",
        "protein_names_refseq": "AP-2mu-PC; AP-50; CG7057-PC; adaptor protein complex 2, mu subunit, isoform C; adaptor protein complex 2; clathrin AP-2 complex; mu2 medium chain of adaptin AP2; mu2-adaptin",
        "tax_id": 7227,
        "disease": "autosomal dominant intellectual developmental disorder 60 with seizures (Disease Ontology:DOID:0061050); heroin dependence (Disease Ontology:DOID:9976)",
        "pathway": " (dme:Dmel_CG7057);  (R-DME-177504);  (R-DME-190873);  (R-DME-196025);  (R-DME-3928665);  (R-DME-416993);  (R-DME-437239);  (R-DME-5099900);  (R-DME-5140745);  (R-DME-8856825);  (R-DME-8856828);  (R-DME-8866427);  (R-DME-8964038)",
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        "go_molecular_function": "GO:0008289 lipid binding;GO:0035615 clathrin adaptor activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0030122 AP-2 adaptor complex;GO:0008021 synaptic vesicle;GO:0030121 AP-1 adaptor complex",
        "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0016192 vesicle-mediated transport;GO:0072583 clathrin-dependent endocytosis;GO:0006896 Golgi to vacuole transport",
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        ],
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        "protein_name": "mitogen-activated protein kinase kinase",
        "gene_name": "lic",
        "organism": "Fruit fly",
        "refseq_name": "licorne",
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                "id": "NP_477162",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477162",
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            }
        ],
        "gene_names_uniprotkb": "lic; CG12244; D-MKK3; DMEK3; DMKK3; DmMKK3; Dmel\\CG12244; Dmel_CG12244; Licorne; MEK3; MKK3; Mek3; Mkk3; Mpk3; dMKK3; l(1)G0252; lic; p38MAPKK; p38",
        "gene_names_refseq": "CG12244; D-MKK3; DMEK3; DMKK3/lic; DMKK3; DmMKK3; Dmel\\CG12244; Licorne; MEK3/MKK3; MEK3; MKK3; Mek3; Mkk3; Mpk3; dMKK3; l(1)G0252; lic; p38MAPKK; p38",
        "protein_names_uniprotkb": "mitogen-activated protein kinase kinase; 2.7.12.2",
        "protein_names_refseq": "CG12244-PA; MEK-kinase 3; Mkk3; drosophila MAP kinase kinase 3; lic-PA; licorne; p38 MAPK",
        "tax_id": 7227,
        "disease": "Pick's disease (Disease Ontology:DOID:11870); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); glioblastoma (Disease Ontology:DOID:3068); malignant astrocytoma (Disease Ontology:DOID:3069); restrictive cardiomyopathy (Disease Ontology:DOID:397); ovarian carcinoma (Disease Ontology:DOID:4001); cervical cancer (Disease Ontology:DOID:4362); retinal disease (Disease Ontology:DOID:5679); progressive supranuclear palsy (Disease Ontology:DOID:678); prostate carcinoma in situ (Disease Ontology:DOID:8634); liver benign neoplasm (Disease Ontology:DOID:916)",
        "pathway": " (dme:Dmel_CG12244);  (R-DME-168638);  (R-DME-2559580);  (R-DME-450302);  (R-DME-6811555);  (R-DME-9833482)",
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                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
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            },
            {
                "id": "2.7.11.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25",
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            }
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        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0000165 MAPK cascade;GO:0007254 JNK cascade;GO:0035313 wound healing, spreading of epidermal cells;GO:0048010 vascular endothelial growth factor receptor signaling pathway",
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        ],
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            {
                "id": "NP_649676",
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        ],
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        "protein_names_uniprotkb": "Signal peptidase complex catalytic subunit SEC11; 3.4.21.89",
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            {
                "id": "NP_001245516",
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            {
                "id": "NP_001034016",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034016",
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        ],
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    },
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            {
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            {
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        "go_molecular_function": "GO:0008061 chitin binding",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "",
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        "hit_score": 1.2,
        "record_id": "Q6ILC6-1",
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        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
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    },
    {
        "uniprot_canonical_ac": "Q6NP91-1",
        "uniprot_id": [
            {
                "id": "TM63_DROME",
                "url": "https://www.uniprot.org/uniprot/Q6NP91",
                "type": "external"
            }
        ],
        "mass": 86149.0,
        "length": 760,
        "protein_name": "Mechanosensitive cation channel Tmem63",
        "gene_name": "Tmem63",
        "organism": "Fruit fly",
        "refseq_name": "transmembrane protein 63",
        "refseq_ac": [
            {
                "id": "NP_610351",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610351",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Tmem63; CG11210",
        "gene_names_refseq": "CG11210; CT31310; Dmel\\CG11210; OSCA/TMEM63; TMEM63; Tmem63; tmem63",
        "protein_names_uniprotkb": "Mechanosensitive cation channel Tmem63; DmTMEM63; Transmembrane protein 63",
        "protein_names_refseq": "CG11210-PA; Tmem63-PA; transmembrane protein 63",
        "tax_id": 7227,
        "disease": "developmental and epileptic encephalopathy 118 (Disease Ontology:DOID:0061176); hypomyelinating leukodystrophy 19 (Disease Ontology:DOID:0070400); hereditary spastic paraplegia 87 (Disease Ontology:DOID:0070456); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); central nervous system disease (Disease Ontology:DOID:331)",
        "pathway": " (dme:Dmel_CG11210);  (R-DME-6798695)",
        "pathway_count": 2,
        "publication_count": 6,
        "publication_id_list": "10731132;12537572;30382938;33657409;35780140;38388853",
        "class_list": "",
        "function": "Mechanosensitive cation channel involved in lysosomal morphology and sensitivity to food texture and humidity (PubMed:30382938, PubMed:33657409, PubMed:35780140, PubMed:38388853). Acts as a regulator of lysosomal morphology by mediating lysosomal mechanosensitivity (PubMed:38388853). Mechanosensitive cation channel in multidendritic neurons (md-L) in the tongue required to discriminate particle sizes in food: acts by promoting activation of md-L neurons in response to mechanical stimuli (PubMed:33657409). Also acts as a sensor of humidity change in olfactory sensory neurons (PubMed:35780140)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
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        "go_molecular_function": "GO:0005227 calcium-activated cation channel activity;GO:0008381 mechanosensitive monoatomic ion channel activity;GO:0140135 mechanosensitive monoatomic cation channel activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0045177 apical part of cell;GO:0005765 lysosomal membrane",
        "go_biological_process": "GO:0032095 regulation of response to food;GO:0007638 mechanosensory behavior;GO:0034220 monoatomic ion transmembrane transport;GO:0098655 monoatomic cation transmembrane transport;GO:0006812 monoatomic cation transport",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q6NP91-1",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6XPX3-1",
        "uniprot_id": [
            {
                "id": "Q6XPX3_DROME",
                "url": "https://www.uniprot.org/uniprot/Q6XPX3",
                "type": "external"
            }
        ],
        "mass": 21087.0,
        "length": 186,
        "protein_name": "Phospholipase A2",
        "gene_name": "sPLA2",
        "organism": "Fruit fly",
        "refseq_name": "secretory phospholipase A2, isoform C",
        "refseq_ac": [
            {
                "id": "NP_001014501",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014501",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "sPLA2; CG11124; CG14507; Dmel\\CG11124; Dmel_CG11124; sPLA[[2]]; secretory phospholipase A[[2]]",
        "gene_names_refseq": "CG11124; CG14507; Dmel\\CG11124; sPLA2; sPLA[[2]]; secretory phospholipase A[[2]]",
        "protein_names_uniprotkb": "Phospholipase A2; 3.1.1.4; Phosphatidylcholine 2-acylhydrolase",
        "protein_names_refseq": "CG11124-PC; sPLA2-PC; secreted phospholipase A2; secretory phospholipase A2, isoform C",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG11124);  (R-DME-1482788);  (R-DME-1482839);  (R-DME-1482925)",
        "pathway_count": 4,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "biomarker_type": "",
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        "ec_number_list": [
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0004623 phospholipase A2 activity",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0016042 lipid catabolic process;GO:0050482 arachidonate secretion;GO:0006644 phospholipid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q6XPX3-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7K003-1",
        "uniprot_id": [
            {
                "id": "MRGBP_DROME",
                "url": "https://www.uniprot.org/uniprot/Q7K003",
                "type": "external"
            }
        ],
        "mass": 22306.0,
        "length": 201,
        "protein_name": "MRG/MORF4L-binding protein",
        "gene_name": "MrgBP",
        "organism": "Fruit fly",
        "refseq_name": "MRG/MORF4L binding protein",
        "refseq_ac": [
            {
                "id": "NP_610417",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610417",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MrgBP; CG13746",
        "gene_names_refseq": "CG13746; Dmel\\CG13746; MRGBP; MrgBP; dMrgBP; dMrgB",
        "protein_names_uniprotkb": "MRG/MORF4L-binding protein",
        "protein_names_refseq": "CG13746-PA; MRG/MORF4L binding protein; MrgBP-PA",
        "tax_id": 7227,
        "disease": "prostate cancer (Disease Ontology:DOID:10283)",
        "pathway": " (dme:Dmel_CG13746)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "10731132;12537572;15528408;32432549",
        "class_list": "",
        "function": "Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of histone H4 'Lys-12' (PubMed:32432549). Component of the Tip60 chromatin-remodeling complex that upon induction of DNA double-strand breaks, mediates the ATP-dependent exchange of unmodified histone H2AV for its phosphorylated and acetylated form H2AVK5acS138ph, leading to transcriptional regulation of selected genes by chromatin remodeling (PubMed:15528408)., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
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        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0035267 NuA4 histone acetyltransferase complex",
        "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0140861 DNA repair-dependent chromatin remodeling",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q7K003-1",
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        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7K2S9-1",
        "uniprot_id": [
            {
                "id": "SPRO6_DROME",
                "url": "https://www.uniprot.org/uniprot/Q7K2S9",
                "type": "external"
            }
        ],
        "mass": 56723.0,
        "length": 526,
        "protein_name": "Crystallomitin loopin-1",
        "gene_name": "loopin-1",
        "organism": "Fruit fly",
        "refseq_name": "loopin-1, isoform C",
        "refseq_ac": [
            {
                "id": "NP_001097338",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097338",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "loopin-1; CG4750; S-Lap6",
        "gene_names_refseq": "CG4750; Dmel\\CG4750; FBgn0259795; S-LAP 6; S-Lap6; anon-WO0140519.81; kl3 lp-1; kl3lp1; loopin-1; loopin",
        "protein_names_uniprotkb": "Crystallomitin loopin-1; Inactive sperm-leucylaminopeptidase 6",
        "protein_names_refseq": "CG4750-PC; Sperm-LeucylAminoPeptidase 6; kl-3 loop protein-1; loopin-1, isoform C; loopin-1-PC",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG4750)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "10731132;12537569;12537572;21466698;30802236",
        "class_list": "",
        "function": "Structural component of the paracrystalline material found in the major mitochondrial derivative of male germ cells (PubMed:30802236). Does not exhibit leucyl aminopeptidase activity (PubMed:30802236)., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0016787 hydrolase activity;GO:0030145 manganese ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0016008 major mitochondrial derivative",
        "go_biological_process": "GO:0006508 proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q7K2S9-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7KN92-1",
        "uniprot_id": [
            {
                "id": "B4GTA_DROME",
                "url": "https://www.uniprot.org/uniprot/Q7KN92",
                "type": "external"
            }
        ],
        "mass": 45616.0,
        "length": 403,
        "protein_name": "Beta1,4-N-acetylgalactosaminyltransferase A",
        "gene_name": "beta4GalNAcTA",
        "organism": "Fruit fly",
        "refseq_name": "beta1,4-N-acetylgalactosaminyltransferase A",
        "refseq_ac": [
            {
                "id": "NP_610946",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610946",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "beta4GalNAcTA; CG8536; beta4GalNAcT1",
        "gene_names_refseq": "BcDNA:GH13356; CG8536; DmGalT; Dmel\\CG8536; anon-WO0118547.128; b4GalNAcTA; beta4Gal-NAcTA; beta4GalNAcT1; beta4GalNAcTA; beta4GalNacTA; beta4GalTA; dbeta4GalTA",
        "protein_names_uniprotkb": "Beta1,4-N-acetylgalactosaminyltransferase A; 2.4.1.244; UDP-GalNAc:betaGlcNAc beta-1,4GalNAc-transferase; dmGalT",
        "protein_names_refseq": "CG8536-PA; beta1,4-N-acetylgalactosaminyltransferase A; beta1,4-N-acetylgalactosaminyltransferase; beta4GalNAcTA-PA",
        "tax_id": 7227,
        "disease": "congenital disorder of glycosylation type IId (Disease Ontology:DOID:0070256); multiple sclerosis (Disease Ontology:DOID:2377); endocrine system disease (Disease Ontology:DOID:28); IgA glomerulonephritis (Disease Ontology:DOID:2986); congenital disorder of glycosylation (Disease Ontology:DOID:5212)",
        "pathway": " (dme:Dmel_CG8536);  (R-DME-2022854);  (R-DME-913709);  (R-DME-975577);  (R-DME-9840309)",
        "pathway_count": 5,
        "publication_count": 9,
        "publication_id_list": "10731132;10731138;12537569;12537572;15563714;17151241;17498683;19139268;22690374",
        "class_list": "glycogene;glycosyltransferase",
        "function": "A beta1,4-N-acetylgalactosaminyltransferase that catalyzes the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc in a beta-1,4 linkage to substrates with a terminal N-acetylglucosamine (GlcNAc) (PubMed:15563714, PubMed:17498683). Specific for glycolipid substrates (PubMed:19139268). Functions downstream of egh/egghead and brn/brainiac to add the 4th sugar during glycosphingolipid elongation to form GalNAc-beta1-4GlcNAc-beta1-3Man-beta1-4Glc-beta1-1Cer from the brn product GlcNAc-beta1-3Man-beta1-4Glc-beta1-1Cer (PubMed:17498683). Required in neuronal cells to regulate normal crawling behavior (PubMed:17151241). Plays a role in glycosphingolipid biosynthesis involved in motor coordination and locomotion (PubMed:17498683). May be involved in the biosynthesis of sialylated glycans by generate acceptor termini for sialylation by SiaT; possibly involved in neural transmission (PubMed:22690374)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 5,
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        "reported_phosphosites": 0,
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        "reported_snv": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 5,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "2.4.1.244",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.244",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008376 acetylgalactosaminyltransferase activity;GO:0033842 N-acetyl-beta-glucosaminyl-derivative 4-beta-N-acetylgalactosaminyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:0006688 glycosphingolipid biosynthetic process;GO:0007528 neuromuscular junction development;GO:0005975 carbohydrate metabolic process;GO:0016258 Golgi apparatus N-glycan diversification;GO:0140269 arthro-series glucosylceramide biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q7KN92-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.11000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7KS11-1",
        "uniprot_id": [
            {
                "id": "Q7KS11_DROME",
                "url": "https://www.uniprot.org/uniprot/Q7KS11",
                "type": "external"
            }
        ],
        "mass": 35520.0,
        "length": 316,
        "protein_name": "Uracil-DNA degrading factor, isoform B; Uracil-DNA degrading factor, isoform C; Uracil-DNA degrading factor, isoform D",
        "gene_name": "Ude",
        "organism": "Fruit fly",
        "refseq_name": "Uracil-DNA degrading factor, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001262929",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262929",
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            }
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    },
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        ],
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            }
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        ],
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        "go_biological_process": "GO:0045687 positive regulation of glial cell differentiation;GO:0021782 glial cell development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development",
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        "protein_names_refseq": "CG3962-PB; Keap1, isoform B; Keap1-PB",
        "tax_id": 7227,
        "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); idiopathic interstitial pneumonia (Disease Ontology:DOID:2797); gallbladder cancer (Disease Ontology:DOID:3121); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); ureteral obstruction (Disease Ontology:DOID:5199); end stage renal disease (Disease Ontology:DOID:783); diabetic retinopathy (Disease Ontology:DOID:8947); pulmonary emphysema (Disease Ontology:DOID:9675)",
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        "organism": "Fruit fly",
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                "id": "NP_476602",
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        "gene_names_refseq": "BG:DS09217.3; CG3903; Dmel\\CG3903; GLI; Gli; gli; l(2)35Dg; l(2)br45; n(2)k09033",
        "protein_names_uniprotkb": "Gliotactin, isoform A; Gliotactin, isoform C; Gliotactin, isoform D; Gliotactin, isoform E; Gliotactin, isoform F",
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        "protein_names_refseq": "CG9096-PD; CycD-PD; Cyclin-dependent kinase interactor 3; cyclin D, isoform D; cyclin D; cyclinD; dCyclinD",
        "tax_id": 7227,
        "disease": "mantle cell lymphoma (Disease Ontology:DOID:0050746); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); colon adenoma (Disease Ontology:DOID:0050912); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); ductal carcinoma in situ (Disease Ontology:DOID:0060074); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); nephritis (Disease Ontology:DOID:10952); urinary bladder cancer (Disease Ontology:DOID:11054); polycystic ovary syndrome (Disease Ontology:DOID:11612); penile benign neoplasm (Disease Ontology:DOID:11624); interstitial cystitis (Disease Ontology:DOID:13949); von Hippel-Lindau disease (Disease Ontology:DOID:14175); renovascular hypertension (Disease Ontology:DOID:1591); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); impotence (Disease Ontology:DOID:1875); atherosclerosis (Disease Ontology:DOID:1936); hepatitis B (Disease Ontology:DOID:2043); nephroblastoma (Disease Ontology:DOID:2154); colon cancer (Disease Ontology:DOID:219); transitional cell carcinoma (Disease Ontology:DOID:2671); cervix carcinoma (Disease Ontology:DOID:2893); granulosa cell tumor (Disease Ontology:DOID:2999); invasive ductal carcinoma (Disease Ontology:DOID:3008); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); germinoma (Disease Ontology:DOID:3304); invasive lobular carcinoma (Disease Ontology:DOID:3457); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); liver cancer (Disease Ontology:DOID:3571); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); ovary adenocarcinoma (Disease Ontology:DOID:3713); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); papillary thyroid carcinoma (Disease Ontology:DOID:3969); ovarian carcinoma (Disease Ontology:DOID:4001); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); seminoma (Disease Ontology:DOID:4440); renal cell carcinoma (Disease Ontology:DOID:4450); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); liver cirrhosis (Disease Ontology:DOID:5082); lung small cell carcinoma (Disease Ontology:DOID:5409); stomach carcinoma (Disease Ontology:DOID:5517); head and neck squamous cell carcinoma (Disease Ontology:DOID:5520); pancreatic solid pseudopapillary carcinoma (Disease Ontology:DOID:6827); hepatocellular carcinoma (Disease Ontology:DOID:684); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); multiple myeloma (Disease Ontology:DOID:9538); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)",
        "pathway": " (dme:Dmel_CG9096);  (R-DME-3214858);  (R-DME-69231);  (R-DME-75815);  (R-DME-8878166);  (R-DME-8934593);  (R-DME-8951936);  (R-DME-9754119);  (R-DME-9929491)",
        "pathway_count": 9,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "",
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        "biomarker_type": "",
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        "disease_count": 57,
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005815 microtubule organizing center;GO:0000307 cyclin-dependent protein kinase holoenzyme complex",
        "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0030307 positive regulation of cell growth;GO:0051301 cell division;GO:0000082 G1/S transition of mitotic cell cycle;GO:1900087 positive regulation of G1/S transition of mitotic cell cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q7KUZ5-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7KVC2-1",
        "uniprot_id": [
            {
                "id": "Q7KVC2_DROME",
                "url": "https://www.uniprot.org/uniprot/Q7KVC2",
                "type": "external"
            }
        ],
        "mass": 18708.0,
        "length": 164,
        "protein_name": "Kinesin motor domain-containing protein",
        "gene_name": "CG32318-PA",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_995952",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_995952",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CG32318-PA; CG32318; CR32318; Dmel\\CG32318; Dmel_CG32318",
        "gene_names_refseq": "CG32318-PA; CG32318; CR32318; Dmel\\CG32318",
        "protein_names_uniprotkb": "Kinesin motor domain-containing protein",
        "protein_names_refseq": "CG32318-PA; uncharacterized protein",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG32318)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "",
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        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding",
        "go_cellular_component": "GO:0005856 cytoskeleton",
        "go_biological_process": "GO:0007018 microtubule-based movement",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q7KVC2-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7KVG9-1",
        "uniprot_id": [
            {
                "id": "LDB_DROME",
                "url": "https://www.uniprot.org/uniprot/Q7KVG9",
                "type": "external"
            }
        ],
        "mass": 64779.0,
        "length": 596,
        "protein_name": "LIM domain-binding protein Chi",
        "gene_name": "Chi",
        "organism": "Fruit fly",
        "refseq_name": "chip, isoform B",
        "refseq_ac": [
            {
                "id": "NP_726403",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_726403",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Chi; CG3924; Ldb",
        "gene_names_refseq": "CG3924; CHIP; Chi; Dmel\\CG3924; LDB; Ldb; chip; chi; dLDB/Chip; dLdb; l(2)04405; l(2)k04405",
        "protein_names_uniprotkb": "LIM domain-binding protein Chi; Protein Chip; dLdb",
        "protein_names_refseq": "CG3924-PB; Chi-PB; chip, isoform B",
        "tax_id": 7227,
        "disease": "nail-patella syndrome (Disease Ontology:DOID:9467)",
        "pathway": " (dme:Dmel_CG3924);  (R-DME-8939236)",
        "pathway_count": 2,
        "publication_count": 13,
        "publication_id_list": "10488341;10488342;10731132;10751171;12537572;18784295;20040493;26738424;31570581;8913756;9334334;9744867;9843490",
        "class_list": "",
        "function": "Positively regulates the activity of the transcription factor ap/apterous by mediating its dimerization (PubMed:10488342, PubMed:9744867). Affects the expression of multiple genes involved in embryonic segmentation (PubMed:9334334). Together with ap/apterous important for wing development and involved in dorso-ventral compartmentalization in wing imaginal discs (PubMed:10488341, PubMed:9843490). Together with Bx involved in Notch signaling in wing imaginal disc by regulating the expression of fng/fringe (PubMed:26738424). Regulates expression of wing margin markers Ser/Serrate and vg/vestigial (PubMed:9843490). Involved in regulation of wing margin enhancer activity; cooperates with mam and sd to regulate cut expression in the wing margin (PubMed:8913756). Involved in central nervous system neurotransmitter production regulated by both ap/apterous and tup/tailup (PubMed:10751171). Together with tup/tailup (isl/islet) required in CCAP neurons to induce posteclosion wing extension behavior (PubMed:18784295). Involved in head development; together with Lim1 or Awh/arrowhead prevents retinal differentiation at the ventral eye-antennal imaginal disc boundary (PubMed:20040493). Forms a complex with Ssdp which mediates transcription of developmental control genes via remote enhancers (PubMed:31570581)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O18353",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030274 LIM domain binding;GO:0003712 transcription coregulator activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0140297 DNA-binding transcription factor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0005700 polytene chromosome",
        "go_biological_process": "GO:0048749 compound eye development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q7KVG9-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7KWG3-1",
        "uniprot_id": [
            {
                "id": "Q7KWG3_DROME",
                "url": "https://www.uniprot.org/uniprot/Q7KWG3",
                "type": "external"
            }
        ],
        "mass": 60338.0,
        "length": 543,
        "protein_name": "Sperm-specific dynein intermediate chain 2, isoform A; Sperm-specific dynein intermediate chain 2, isoform C",
        "gene_name": "Sdic2",
        "organism": "Fruit fly",
        "refseq_name": "Sperm-specific dynein intermediate chain 2, isoform C",
        "refseq_ac": [
            {
                "id": "NP_001285481",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285481",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Sdic2; CG33497; Dmel\\CG33497; Dmel_CG33497; Sdic4; Sdic:CG33497; Sdic:CG33499; Sdic",
        "gene_names_refseq": "CG33497; Dmel\\CG33497; Sdic2; Sdic:CG33497; Sdic",
        "protein_names_uniprotkb": "Sperm-specific dynein intermediate chain 2, isoform A; Sperm-specific dynein intermediate chain 2, isoform C",
        "protein_names_refseq": "CG33497-PC; Sdic2-PC; Sdic:CG33497; Sperm-specific dynein intermediate chain 2, isoform C",
        "tax_id": 7227,
        "disease": "autosomal recessive primary microcephaly (Disease Ontology:DOID:0070296)",
        "pathway": " (dme:Dmel_CG33497);  (R-DME-3371497);  (R-DME-6807878);  (R-DME-6811436);  (R-DME-9646399)",
        "pathway_count": 5,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
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        "predicted_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0045503 dynein light chain binding;GO:0045504 dynein heavy chain binding",
        "go_cellular_component": "GO:0036126 sperm flagellum;GO:0005868 cytoplasmic dynein complex",
        "go_biological_process": "GO:0007018 microtubule-based movement",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q7KWG3-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7M3J6-1",
        "uniprot_id": [
            {
                "id": "Q7M3J6_DROME",
                "url": "https://www.uniprot.org/uniprot/Q7M3J6",
                "type": "external"
            }
        ],
        "mass": 62188.0,
        "length": 584,
        "protein_name": "Gastrin/cholecystokinin type B receptor",
        "gene_name": "CCKLR-17D3",
        "organism": "Fruit fly",
        "refseq_name": "Cholecystokinin-like receptor at 17D3",
        "refseq_ac": [
            {
                "id": "NP_001097023",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097023",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CCKLR-17D3; CCKLR-17D3-R; CCKLR-D3; CG32540; CG6861; CG6881; CG6894; DSK-R1; Dmel\\CG32540; Dmel_CG32540; DskR-1; SK-R; anon-WO0131005.21; anon-WO0170980.64; anon-WO0170980.65",
        "gene_names_refseq": "CCKLR-17D3-R; CCKLR-17D3; CCKLR-D3; CG32540; CG6861; CG6881; CG6894; DSK-R1; Dmel\\CG32540; DskR-1; SK-R; anon-WO0131005.21; anon-WO0170980.64; anon-WO0170980.65",
        "protein_names_uniprotkb": "Gastrin/cholecystokinin type B receptor; Cholecystokinin-2 receptor",
        "protein_names_refseq": "CCK-like receptor at 17D3; CCKLR-17D3-PB; CG32540-PB; Cholecystokinin-like receptor at 17D3; DSK-receptor2; sulfakinin receptor",
        "tax_id": 7227,
        "disease": "colitis (Disease Ontology:DOID:0060180); cholelithiasis (Disease Ontology:DOID:10211); toxic shock syndrome (Disease Ontology:DOID:14115); pancreatic cancer (Disease Ontology:DOID:1793); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); panic disorder (Disease Ontology:DOID:594); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (dme:Dmel_CG32540)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "Receptor for the peptide hormones gastrin and cholecystokinin (CCK). Expressed throughout the central nervous system, where it modulates processes such as anxiety, analgesia, arousal and neuroleptic activity. Couples to both GNAI1 and GNAQ signaling pathways, but not to GNAS. Upon gastrin activation, reduces glucose absorption in intestinal epithelial cells by downregulating SGLT1 and GLUT2 expression through suppression of the PI3K/Akt/eIF4B pathway. In the kidney, decreases SGLT2 expression under high-glucose conditions via ERK/NF-kappa-B signaling., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
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        "reported_c_glycosites_with_glycan": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 8,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9VWQ9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008188 neuropeptide receptor activity;GO:0015054 gastrin receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0008344 adult locomotory behavior",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q7M3J6-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7PL91-1",
        "uniprot_id": [
            {
                "id": "Q7PL91_DROME",
                "url": "https://www.uniprot.org/uniprot/Q7PL91",
                "type": "external"
            }
        ],
        "mass": 10741.0,
        "length": 94,
        "protein_name": "NADH dehydrogenase (Ubiquinone) AGGG subunit, isoform A; NADH dehydrogenase (Ubiquinone) AGGG subunit, isoform B",
        "gene_name": "ND-AGGG",
        "organism": "Fruit fly",
        "refseq_name": "NADH dehydrogenase (ubiquinone) AGGG subunit, isoform A",
        "refseq_ac": [
            {
                "id": "NP_001015476",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015476",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ND-AGGG; CG40002; CG40472; CR40472; Dmel\\CG40002; Dmel\\CG40472; Dmel_CG40002; Dmel_CG40472; ND-AGGGL; NDUFB2; dNDUFB2A; dNDUFB2B; l7A",
        "gene_names_refseq": "CG40002; Dmel\\CG40002; ND-AGGG; NDUFB2; dNDUFB2A; l7A",
        "protein_names_uniprotkb": "NADH dehydrogenase (Ubiquinone) AGGG subunit, isoform A; NADH dehydrogenase (Ubiquinone) AGGG subunit, isoform B",
        "protein_names_refseq": "CG40002-PA; NADH dehydrogenase (ubiquinone) AGGG subunit, isoform A; NADH ubiquinone oxidoreductase AGGG; NADH:ubiquinone oxidoreductase AGGG subunit; ND-AGGG-PA; lethal 7A; lethal7A",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG40002);  (dme:Dmel_CG40472);  (R-DME-611105);  (R-DME-6799198)",
        "pathway_count": 4,
        "publication_count": 13,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;36622099;36952377",
        "class_list": "",
        "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "go_molecular_function": "",
        "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I",
        "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:1902600 proton transmembrane transport",
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        "record_id": "Q7PL91-1",
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        "kg_view_protein": true
    },
    {
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            {
                "id": "Q7PLK1_DROME",
                "url": "https://www.uniprot.org/uniprot/Q7PLK1",
                "type": "external"
            }
        ],
        "mass": 42316.0,
        "length": 359,
        "protein_name": "Uncharacterized protein",
        "gene_name": "Dmel\\CG40298",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_001036631",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036631",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG40298; CG40298; Dmel_CG40298",
        "gene_names_refseq": "CG40298; Dmel\\CG40298",
        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG40298-PA; uncharacterized protein",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG40298)",
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        "publication_count": 11,
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    },
    {
        "uniprot_canonical_ac": "Q7YZ95-1",
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            {
                "id": "Q7YZ95_DROME",
                "url": "https://www.uniprot.org/uniprot/Q7YZ95",
                "type": "external"
            }
        ],
        "mass": 61713.0,
        "length": 559,
        "protein_name": "S-phase kinase-associated protein 2",
        "gene_name": "Skp2",
        "organism": "Fruit fly",
        "refseq_name": "S-phase kinase-associated protein 2, isoform A",
        "refseq_ac": [
            {
                "id": "NP_730815",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_730815",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Skp2; 153298_at; CG9772; Dmel\\CG9772; Dmel_CG9772; F-box; FBXL1; SKP2; dSkp2",
        "gene_names_refseq": "153298_at; CG9772; Dmel\\CG9772; F-box; FBXL1; SKP2; Skp2; dSkp2",
        "protein_names_uniprotkb": "S-phase kinase-associated protein 2; Cyclin-A/CDK2-associated protein p45; F-box protein Skp2",
        "protein_names_refseq": "CG9772-PA; S-phase kinase-associated protein 2, isoform A; Skp2-PA",
        "tax_id": 7227,
        "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); endometrial hyperplasia (Disease Ontology:DOID:0080365); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); breast cancer (Disease Ontology:DOID:1612); transitional cell carcinoma (Disease Ontology:DOID:2671); renal cell carcinoma (Disease Ontology:DOID:4450); lung small cell carcinoma (Disease Ontology:DOID:5409); hepatocellular carcinoma (Disease Ontology:DOID:684); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991)",
        "pathway": " (dme:Dmel_CG9772);  (R-DME-174178);  (R-DME-187577);  (R-DME-5689880);  (R-DME-68949);  (R-DME-69231);  (R-DME-8939902);  (R-DME-8951664);  (R-DME-983168)",
        "pathway_count": 9,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, NBN, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration. Following phosphorylation in response to DNA damage, mediates 'Lys-63'-linked ubiquitination of NBN, promoting ATM recruitment to DNA damage sites and DNA repair via homologous recombination., [UniProtKB, UniProtKB]",
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        "secondary_ac_list": "Q7YZ96",
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        "go_molecular_function": "GO:0016301 kinase activity;GO:0140767 enzyme-substrate adaptor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex",
        "go_biological_process": "GO:0048749 compound eye development;GO:0000278 mitotic cell cycle;GO:0031647 regulation of protein stability;GO:0000082 G1/S transition of mitotic cell cycle;GO:0045787 positive regulation of cell cycle",
        "synthesized_glycan_count": 0,
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        "record_id": "Q7YZ95-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VG88-1",
        "uniprot_id": [
            {
                "id": "Q9VG88_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VG88",
                "type": "external"
            }
        ],
        "mass": 26333.0,
        "length": 230,
        "protein_name": "EF-hand domain-containing protein",
        "gene_name": "BcDNA:RH08915; CT39356",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform E",
        "refseq_ac": [
            {
                "id": "NP_001262501",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262501",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "BcDNA:RH08915; CT39356; BcDNA:AT09395; BcDNA:RH08915; CG17756; CG33098; CT39356; Dmel\\CG33098; Dmel_CG33098; RLC3",
        "gene_names_refseq": "BcDNA:AT09395; BcDNA:RH08915; CG17756; CG33098; CT39356; Dmel\\CG33098; RLC3",
        "protein_names_uniprotkb": "EF-hand domain-containing protein",
        "protein_names_refseq": "CG33098-PE; uncharacterized protein, isoform E",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG33098)",
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        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0032036 myosin heavy chain binding",
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        "go_biological_process": "GO:0009791 post-embryonic development;GO:0040011 locomotion",
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    },
    {
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                "id": "Q86BA5_DROME",
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        ],
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        "protein_name": "P24-related-2, isoform A; P24-related-2, isoform B",
        "gene_name": "p24-2",
        "organism": "Fruit fly",
        "refseq_name": "p24-related-2, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001189205",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189205",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "p24-2; CG33105; CG9443; Dmel\\CG33105; Dmel_CG33105; p24",
        "gene_names_refseq": "CG33105; CG9443; Dmel\\CG33105; p24-2; p24",
        "protein_names_uniprotkb": "P24-related-2, isoform A; P24-related-2, isoform B",
        "protein_names_refseq": "CG33105-PB; p24-2-PB; p24-related-2, isoform B",
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        "pathway": " (dme:Dmel_CG33105);  (R-DME-6807878);  (R-DME-6811434)",
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        "go_molecular_function": "GO:0038024 cargo receptor activity",
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        ],
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        "protein_name": "Chromator, isoform A; Chromator, isoform B; Chromator, isoform C; Chromator, isoform D; Chromator, isoform E",
        "gene_name": "Chro",
        "organism": "Fruit fly",
        "refseq_name": "chromator, isoform D",
        "refseq_ac": [
            {
                "id": "NP_001262226",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262226",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Chro; CG10712; CHRIZ; CHRO; Chiz; Chriz-WR; Chriz; Chro(Chriz); Chr; Dmel\\CG10712; Dmel_CG10712; MRG15; anon-EST:fe2E3; chro",
        "gene_names_refseq": "CG10712; CHRIZ/CHRO; CHRIZ; CHRO/CHRIZ; CHRO; Chiz; Chriz-WR; Chriz; Chro(Chriz); Chro; Chr; Dmel\\CG10712; MRG15; anon-EST:fe2E3; chro",
        "protein_names_uniprotkb": "Chromator, isoform A; Chromator, isoform B; Chromator, isoform C; Chromator, isoform D; Chromator, isoform E",
        "protein_names_refseq": "CG10712-PD; Chro-PD; anon-fast-evolving-2E3; chromator, isoform D; chromo domain protein interacting with Z4; chromobox protein interacting with Z4",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG10712);  (R-DME-983231);  (R-DME-9843940)",
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            {
                "id": "Q8IMZ4_DROME",
                "url": "https://www.uniprot.org/uniprot/Q8IMZ4",
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            }
        ],
        "mass": 55565.0,
        "length": 495,
        "protein_name": "P53, isoform B",
        "gene_name": "p53",
        "organism": "Fruit fly",
        "refseq_name": "p53, isoform B",
        "refseq_ac": [
            {
                "id": "NP_996267",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996267",
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            }
        ],
        "gene_names_uniprotkb": "p53; CG10873; CG31325; CG33336; D-p53; DMP53; Dm-P53; DmP53; Dmel\\CG33336; Dmel_CG33336; Dmp53; Dp53; P53; dmP53; dmp53; dp53; prac",
        "gene_names_refseq": "CG10873; CG31325; CG33336; D-p53; DMP53; Dm-P53; DmP53; Dmel\\CG33336; Dmp53; Dp53; P53; dmP53; dmp53; dp53; p53; prac",
        "protein_names_uniprotkb": "P53, isoform B",
        "protein_names_refseq": "CG33336-PB; Dmp53; drosophila p53; p53, isoform B; p53-PB; p53-like regulator of apoptosis and cell cycle; protein 53",
        "tax_id": 7227,
        "disease": "angiosarcoma (Disease Ontology:DOID:0001816); pterygium (Disease Ontology:DOID:0002116); ADULT syndrome (Disease Ontology:DOID:0050601); diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); CHARGE syndrome (Disease Ontology:DOID:0050834); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); medulloblastoma (Disease Ontology:DOID:0050902); myelodysplastic syndrome (Disease Ontology:DOID:0050908); pre-malignant neoplasm (Disease Ontology:DOID:0060071); ductal carcinoma in situ (Disease Ontology:DOID:0060074); triple-receptor negative breast cancer (Disease Ontology:DOID:0060081); Rapp-Hodgkin syndrome (Disease Ontology:DOID:0060330); EEC syndrome (Disease Ontology:DOID:0060782); ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3 (Disease Ontology:DOID:0060783); bladder exstrophy-epispadias-cloacal exstrophy complex (Disease Ontology:DOID:0080173); bladder exstrophy (Disease Ontology:DOID:0080174); colorectal carcinoma (Disease Ontology:DOID:0080199); adenoid cystic carcinoma (Disease Ontology:DOID:0080202); orofacial cleft 8 (Disease Ontology:DOID:0080401); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); graft-versus-host disease (Disease Ontology:DOID:0081267); traumatic brain injury (Disease Ontology:DOID:0081292); T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0081312); split hand-foot malformation 4 (Disease Ontology:DOID:0090023); ankyloblepharon-ectodermal defects-cleft lip/palate syndrome (Disease Ontology:DOID:0090119); Li-Fraumeni syndrome 1 (Disease Ontology:DOID:0111503); mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); prostate cancer (Disease Ontology:DOID:10283); prostate carcinoma (Disease Ontology:DOID:10286); aggressive NK-cell leukemia (Disease Ontology:DOID:1035); stomach cancer (Disease Ontology:DOID:10534); primary open angle glaucoma (Disease Ontology:DOID:1070); otitis media (Disease Ontology:DOID:10754); nasal cavity cancer (Disease Ontology:DOID:10811); cholesteatoma of middle ear (Disease Ontology:DOID:10964); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); sarcoma (Disease Ontology:DOID:1115); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); Graves' disease (Disease Ontology:DOID:12361); leukemia (Disease Ontology:DOID:1240); dilated cardiomyopathy (Disease Ontology:DOID:12930); lung cancer (Disease Ontology:DOID:1324); paranasal sinus benign neoplasm (Disease Ontology:DOID:1350); low tension glaucoma (Disease Ontology:DOID:13544); endometrial cancer (Disease Ontology:DOID:1380); disease of cellular proliferation (Disease Ontology:DOID:14566); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); squamous cell carcinoma (Disease Ontology:DOID:1749); pancreatic cancer (Disease Ontology:DOID:1793); melanoma (Disease Ontology:DOID:1909); ectodermal dysplasia (Disease Ontology:DOID:2121); nephroblastoma (Disease Ontology:DOID:2154); basal cell carcinoma (Disease Ontology:DOID:2513); hematologic cancer (Disease Ontology:DOID:2531); choroid plexus papilloma (Disease Ontology:DOID:2626); transitional cell carcinoma (Disease Ontology:DOID:2671); dyskeratosis congenita (Disease Ontology:DOID:2729); endometrial adenocarcinoma (Disease Ontology:DOID:2870); endometrial carcinoma (Disease Ontology:DOID:2871); Epstein-Barr virus infectious disease (Disease Ontology:DOID:2938); testicular cancer (Disease Ontology:DOID:2998); breast ductal carcinoma (Disease Ontology:DOID:3007); Li-Fraumeni syndrome (Disease Ontology:DOID:3012); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); serous cystadenocarcinoma (Disease Ontology:DOID:3114); ischemia (Disease Ontology:DOID:326); osteosarcoma (Disease Ontology:DOID:3347); coronary artery disease (Disease Ontology:DOID:3393); cervical adenocarcinoma (Disease Ontology:DOID:3702); gastric adenocarcinoma (Disease Ontology:DOID:3717); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); papillary thyroid carcinoma (Disease Ontology:DOID:3969); coronary restenosis (Disease Ontology:DOID:4247); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); bronchiolo-alveolar adenocarcinoma (Disease Ontology:DOID:4926); myelofibrosis (Disease Ontology:DOID:4971); lung small cell carcinoma (Disease Ontology:DOID:5409); primary ovarian insufficiency (Disease Ontology:DOID:5426); ovary serous adenocarcinoma (Disease Ontology:DOID:5744); oral submucous fibrosis (Disease Ontology:DOID:5773); malignant peripheral nerve sheath tumor (Disease Ontology:DOID:5940); adenoma (Disease Ontology:DOID:657); hepatocellular carcinoma (Disease Ontology:DOID:684); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); pancreatic intraductal papillary-mucinous neoplasm (Disease Ontology:DOID:7575); meninges sarcoma (Disease Ontology:DOID:7614); gastroesophageal reflux disease (Disease Ontology:DOID:8534); prostate carcinoma in situ (Disease Ontology:DOID:8634); vascular dementia (Disease Ontology:DOID:8725); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); multiple myeloma (Disease Ontology:DOID:9538); primary ciliary dyskinesia (Disease Ontology:DOID:9562); oral mucosa leukoplakia (Disease Ontology:DOID:9655)",
        "pathway": " (R-DME-2559586);  (R-DME-5689880);  (R-DME-5689896);  (R-DME-5693565);  (R-DME-6804754);  (R-DME-6804756);  (R-DME-6804757);  (R-DME-6804758);  (R-DME-6804759);  (R-DME-6804760);  (R-DME-6811555);  (R-DME-69473);  (R-DME-69541);  (R-DME-8939236);  (R-DME-8941855);  (R-DME-9833482)",
        "pathway_count": 16,
        "publication_count": 11,
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        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0014016 neuroblast differentiation;GO:0046533 negative regulation of photoreceptor cell differentiation;GO:0060785 regulation of apoptosis involved in tissue homeostasis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q8IMZ4-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IN02-1",
        "uniprot_id": [
            {
                "id": "Q8IN02_DROME",
                "url": "https://www.uniprot.org/uniprot/Q8IN02",
                "type": "external"
            }
        ],
        "mass": 31620.0,
        "length": 281,
        "protein_name": "diphthine methyl ester synthase",
        "gene_name": "Dph5",
        "organism": "Fruit fly",
        "refseq_name": "diphthamide methyltransferase",
        "refseq_ac": [
            {
                "id": "NP_524452",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524452",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dph5; BcDNA.LD12153; BcDNA:LD12153; CG31289; CG5275; Dmel\\CG31289; Dmel_CG31289; l(3)L4910",
        "gene_names_refseq": "BcDNA.LD12153; BcDNA:LD12153; CG31289; CG5275; Dmel\\CG31289; Dph5; l(3)L4910",
        "protein_names_uniprotkb": "diphthine methyl ester synthase; 2.1.1.314",
        "protein_names_refseq": "CG31289-PA; Dph5-PA; diphthamide methyltransferase",
        "tax_id": 7227,
        "disease": "neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties (Disease Ontology:DOID:0070479)",
        "pathway": " (dme:Dmel_CG31289);  (R-DME-5358493)",
        "pathway_count": 2,
        "publication_count": 11,
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        "class_list": "",
        "function": "S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "2.1.1.314",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.314",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004164 diphthine synthase activity;GO:0141133 diphthine methyl ester synthase activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0045727 positive regulation of translation;GO:0032259 methylation;GO:0017183 protein histidyl modification to diphthamide",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q8IN02-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
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            {
                "id": "Q8IND6_DROME",
                "url": "https://www.uniprot.org/uniprot/Q8IND6",
                "type": "external"
            }
        ],
        "mass": 31627.0,
        "length": 280,
        "protein_name": "SCP domain-containing protein",
        "gene_name": "NEST:bs01d08",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001262608",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262608",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NEST:bs01d08; CG31296; Dmel\\CG31296; Dmel_CG31296",
        "gene_names_refseq": "CG31296; Dmel\\CG31296; NEST:bs01d08",
        "protein_names_uniprotkb": "SCP domain-containing protein",
        "protein_names_refseq": "CG31296-PB; uncharacterized protein, isoform B",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG31296)",
        "pathway_count": 1,
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        "record_id": "Q8IND6-1",
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        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8ING5-1",
        "uniprot_id": [
            {
                "id": "Q8ING5_DROME",
                "url": "https://www.uniprot.org/uniprot/Q8ING5",
                "type": "external"
            }
        ],
        "mass": 38473.0,
        "length": 341,
        "protein_name": "Vesicle-fusing ATPase",
        "gene_name": "Dmel\\CG31495",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001287320",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287320",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG31495; CG31495; CG9931; Dmel_CG31495",
        "gene_names_refseq": "CG31495; CG9931; Dmel\\CG31495",
        "protein_names_uniprotkb": "Vesicle-fusing ATPase; 3.6.4.6",
        "protein_names_refseq": "CG31495-PB; uncharacterized protein, isoform B",
        "tax_id": 7227,
        "disease": "oculocutaneous albinism (Disease Ontology:DOID:0050632); autism spectrum disorder (Disease Ontology:DOID:0060041); developmental and epileptic encephalopathy 96 (Disease Ontology:DOID:0070377); temporal lobe epilepsy (Disease Ontology:DOID:3328); cocaine dependence (Disease Ontology:DOID:9975)",
        "pathway": " (dme:Dmel_CG31495)",
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        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
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        "ec_number_list": [
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                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
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            {
                "id": "7.2.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-",
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            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
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            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "3.6.4.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12",
                "type": "external"
            },
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "5.6.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5",
                "type": "external"
            },
            {
                "id": "2.7.4.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3",
                "type": "external"
            },
            {
                "id": "5.6.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.-.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-",
                "type": "external"
            },
            {
                "id": "5.6.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "5.6.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity",
        "go_cellular_component": "GO:0005795 Golgi stack",
        "go_biological_process": "GO:0035494 SNARE complex disassembly;GO:0043001 Golgi to plasma membrane protein transport;GO:0006891 intra-Golgi vesicle-mediated transport",
        "synthesized_glycan_count": 0,
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        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8INH6-1",
        "uniprot_id": [
            {
                "id": "Q8INH6_DROME",
                "url": "https://www.uniprot.org/uniprot/Q8INH6",
                "type": "external"
            }
        ],
        "mass": 116386.0,
        "length": 1025,
        "protein_name": "glutamyl aminopeptidase",
        "gene_name": "CG11688; CG8775",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform C",
        "refseq_ac": [
            {
                "id": "NP_731787",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_731787",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CG11688; CG8775; CG11688; CG32473; CG8775; Dmel\\CG32473; Dmel_CG32473; GM08240p",
        "gene_names_refseq": "CG11688; CG32473; CG8775; Dmel\\CG32473; GM08240p",
        "protein_names_uniprotkb": "glutamyl aminopeptidase; 3.4.11.7",
        "protein_names_refseq": "CG32473-PC; uncharacterized protein, isoform C",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG32473)",
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        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0004230 glutamyl aminopeptidase activity;GO:0070006 metalloaminopeptidase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane;GO:0005615 extracellular space",
        "go_biological_process": "GO:0006508 proteolysis;GO:0002003 angiotensin maturation;GO:0043171 peptide catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q8INH6-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.010000.000000100000000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8INJ3-1",
        "uniprot_id": [
            {
                "id": "Q8INJ3_DROME",
                "url": "https://www.uniprot.org/uniprot/Q8INJ3",
                "type": "external"
            }
        ],
        "mass": 34913.0,
        "length": 319,
        "protein_name": "Mitochondrial glutamate carrier 2",
        "gene_name": "GC2",
        "organism": "Fruit fly",
        "refseq_name": "glutamate carrier 2, isoform B",
        "refseq_ac": [
            {
                "id": "NP_731657",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_731657",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GC2; CG12201; DmGC2; Dmel\\CG12201; Dmel_CG12201",
        "gene_names_refseq": "CG12201; DmGC2; Dmel\\CG12201; GC2",
        "protein_names_uniprotkb": "Mitochondrial glutamate carrier 2; Glutamate/H(+) symporter 2; Solute carrier family 25 member 18",
        "protein_names_refseq": "CG12201-PB; GC2-PB; glutamate carrier 2, isoform B",
        "tax_id": 7227,
        "disease": "developmental and epileptic encephalopathy 3 (Disease Ontology:DOID:0080440); intrahepatic cholestasis (Disease Ontology:DOID:1852); common bile duct disease (Disease Ontology:DOID:4137); citrullinemia (Disease Ontology:DOID:9273)",
        "pathway": " (R-DME-442660);  (R-DME-9856872)",
        "pathway_count": 2,
        "publication_count": 11,
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        "class_list": "",
        "function": "Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (symport system)., [UniProtKB, UniProtKB]",
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        "go_molecular_function": "GO:0005314 high-affinity L-glutamate transmembrane transporter activity;GO:0005313 L-glutamate transmembrane transporter activity;GO:0015183 L-aspartate transmembrane transporter activity",
        "go_cellular_component": "GO:0005743 mitochondrial inner membrane",
        "go_biological_process": "GO:0015810 aspartate transmembrane transport;GO:0015813 L-glutamate transmembrane transport;GO:0043490 malate-aspartate shuttle",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
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        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
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    },
    {
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            {
                "id": "Q8INP3_DROME",
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                "type": "external"
            }
        ],
        "mass": 38670.0,
        "length": 372,
        "protein_name": "Uncharacterized protein",
        "gene_name": "CG33187",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform D",
        "refseq_ac": [
            {
                "id": "NP_001027159",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027159",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CG33187; BcDNA:RE70963; CG16750; CG16751; CG33188; CG33936; CG33937; CG3393; CG43675; Dmel\\CG43675; Dmel_CG43675; anon-85Da; drn",
        "gene_names_refseq": "BcDNA:RE70963; CG16750; CG16751; CG33187; CG33188; CG33936; CG33937; CG3393; CG43675; Dmel\\CG43675; anon-85Da; drn",
        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG43675-PD; uncharacterized protein, isoform D",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG43675)",
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        "secondary_ac_list": "Q4AB40",
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        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8INX9-1",
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            {
                "id": "Q8INX9_DROME",
                "url": "https://www.uniprot.org/uniprot/Q8INX9",
                "type": "external"
            }
        ],
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        "length": 59,
        "protein_name": "Uncharacterized protein",
        "gene_name": "Dmel\\CG31788",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001286035",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286035",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG31788; CG31788; Dmel_CG31788",
        "gene_names_refseq": "CG31788; Dmel\\CG31788",
        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG31788-PB; uncharacterized protein, isoform B",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG31788)",
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        "class_list": "",
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        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8INY4-1",
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            {
                "id": "Q8INY4_DROME",
                "url": "https://www.uniprot.org/uniprot/Q8INY4",
                "type": "external"
            }
        ],
        "mass": 30699.0,
        "length": 279,
        "protein_name": "Proteasome subunit beta",
        "gene_name": "Prosbeta5R2",
        "organism": "Fruit fly",
        "refseq_name": "proteasome beta5 subunit-related 2, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001286022",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286022",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Prosbeta5R2; 31742; CG31742; Dmel\\CG31742; Dmel_CG31742; anon-AE003657.1; beta5R2",
        "gene_names_refseq": "31742; CG31742; Dmel\\CG31742; Prosbeta5R2; anon-AE003657.1; beta5R2",
        "protein_names_uniprotkb": "Proteasome subunit beta",
        "protein_names_refseq": "AE003657 - proteasome beta subunit; CG31742-PB; Prosbeta5R2-PB; proteasome beta5 subunit-related 2, isoform B",
        "tax_id": 7227,
        "disease": "proteasome-associated autoinflammatory syndrome 1 (Disease Ontology:DOID:0050553)",
        "pathway": " (dme:Dmel_CG31742);  (R-DME-1236974);  (R-DME-1236978);  (R-DME-9907900);  (R-DME-9912633)",
        "pathway_count": 5,
        "publication_count": 11,
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        "class_list": "",
        "function": "Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB, UniProtKB]; Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "biomarker_type": "",
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        "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004298 threonine-type endopeptidase activity",
        "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005829 cytosol",
        "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q8INY4-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8INZ7-1",
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            {
                "id": "Q8INZ7_DROME",
                "url": "https://www.uniprot.org/uniprot/Q8INZ7",
                "type": "external"
            }
        ],
        "mass": 15590.0,
        "length": 140,
        "protein_name": "Mitochondrial pyruvate carrier",
        "gene_name": "Mpc2c",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001285999",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285999",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Mpc2c; CG32832; Dmel\\CG32832; Dmel_CG32832; NEST:bs10d12; NEST:bs21e09; bs21e09.y1",
        "gene_names_refseq": "CG32832; Dmel\\CG32832; NEST:bs10d12; NEST:bs21e09; bs21e09.y1",
        "protein_names_uniprotkb": "Mitochondrial pyruvate carrier",
        "protein_names_refseq": "CG32832-PB; uncharacterized protein, isoform B",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG32832)",
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        "class_list": "",
        "function": "Mediates the uptake of pyruvate into mitochondria., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
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        "go_molecular_function": "GO:0050833 pyruvate transmembrane transporter activity",
        "go_cellular_component": "GO:0005743 mitochondrial inner membrane",
        "go_biological_process": "GO:0006850 pyruvate import into mitochondria",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
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    },
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            {
                "id": "Q8IP31_DROME",
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                "type": "external"
            }
        ],
        "mass": 48337.0,
        "length": 427,
        "protein_name": "Carboxypeptidase",
        "gene_name": "Dmel\\CG31823",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_723939",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_723939",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG31823; BG:DS00365.3; CG31823; CG7647; Dmel_CG31823",
        "gene_names_refseq": "BG:DS00365.3; CG31823; CG7647; Dmel\\CG31823",
        "protein_names_uniprotkb": "Carboxypeptidase; 3.4.16.-",
        "protein_names_refseq": "CG31823-PA; uncharacterized protein",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG31823)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "May be involved in vascular wall and kidney homeostasis., [UniProtKB, UniProtKB]",
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            {
                "id": "Q8IP70_DROME",
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        ],
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        "protein_name": "Dpr-interacting protein kappa, isoform A",
        "gene_name": "DIP-kappa",
        "organism": "Fruit fly",
        "refseq_name": "Dpr-interacting protein kappa, isoform A",
        "refseq_ac": [
            {
                "id": "NP_723828",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_723828",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "DIP-kappa; 31814; BG:DS08249.1; CG31814; DIPkappa; Dmel\\CG31814; Dmel_CG31814",
        "gene_names_refseq": "31814; BG:DS08249.1; CG31814; DIP-kappa; DIPkappa; Dmel\\CG31814",
        "protein_names_uniprotkb": "Dpr-interacting protein kappa, isoform A",
        "protein_names_refseq": "CG31814-PA; DIP-kappa-PA; Dpr-interacting protein kappa, isoform A",
        "tax_id": 7227,
        "disease": "primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); uterine fibroid (Disease Ontology:DOID:13223); ovary epithelial cancer (Disease Ontology:DOID:2152); ovarian cancer (Disease Ontology:DOID:2394); congestive heart failure (Disease Ontology:DOID:6000)",
        "pathway": " (dme:Dmel_CG31814);  (R-DME-1474228);  (R-DME-1971475);  (R-DME-2022928);  (R-DME-2024096);  (R-DME-216083);  (R-DME-3000171);  (R-DME-3000178);  (R-DME-375165);  (R-DME-419037);  (R-DME-445144);  (R-DME-5673001);  (R-DME-9769739);  (R-DME-9913351)",
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        "go_cellular_component": "GO:0032589 neuron projection membrane;GO:0005886 plasma membrane;GO:0043005 neuron projection",
        "go_biological_process": "GO:0007529 establishment of synaptic specificity at neuromuscular junction",
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    },
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            {
                "id": "Q8IP77_DROME",
                "url": "https://www.uniprot.org/uniprot/Q8IP77",
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            }
        ],
        "mass": 18820.0,
        "length": 162,
        "protein_name": "N-alpha-acetyltransferase 20",
        "gene_name": "Dmel\\CG31730",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
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            {
                "id": "NP_723799",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_723799",
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            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG31730; CG31730; Dmel_CG31730",
        "gene_names_refseq": "CG31730; Dmel\\CG31730",
        "protein_names_uniprotkb": "N-alpha-acetyltransferase 20; 2.3.1.254; Methionine N-acetyltransferase; N-acetyltransferase 5; N-terminal acetyltransferase B complex catalytic subunit NAA20; N-terminal acetyltransferase B complex catalytic subunit NAT5; NatB catalytic subunit",
        "protein_names_refseq": "CG31730-PA; uncharacterized protein",
        "tax_id": 7227,
        "disease": "",
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        "class_list": "",
        "function": "Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
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            {
                "id": "2.3.1.254",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.254",
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            }
        ],
        "go_molecular_function": "GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:0120518 protein N-terminal-methionine acetyltransferase activity",
        "go_cellular_component": "GO:0031416 NatB complex",
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            {
                "id": "Q9VKB0_DROME",
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            }
        ],
        "mass": 85978.0,
        "length": 747,
        "protein_name": "threonine--tRNA ligase",
        "gene_name": "ThrRS",
        "organism": "Fruit fly",
        "refseq_name": "Threonyl-tRNA synthetase, isoform D",
        "refseq_ac": [
            {
                "id": "NP_001285868",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285868",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ThrRS; 2L16; 3; Aats-thr; CG5353; Dmel\\CG5353; Dmel_CG5353; P539; TARS; TRS; dTARS; l(2)k04203; threonyl-tRNA synthetase",
        "gene_names_refseq": "2L16; 42/3; Aats-thr; CG5353; Dmel\\CG5353; P539; TARS; TRS; ThrRS; dTARS; l(2)k04203; threonyl-tRNA synthetase",
        "protein_names_uniprotkb": "threonine--tRNA ligase; 6.1.1.3; Threonyl-tRNA synthetase",
        "protein_names_refseq": "CG5353-PD; ThrRS-PD; Threonyl-tRNA synthetase, isoform D; threonyl-tRNA synthetase",
        "tax_id": 7227,
        "disease": "combined oxidative phosphorylation deficiency 21 (Disease Ontology:DOID:0111465); nonphotosensitive trichothiodystrophy (Disease Ontology:DOID:0111867); nonphotosensitive trichothiodystrophy 7 (Disease Ontology:DOID:0111870); amino acid metabolic disorder (Disease Ontology:DOID:9252)",
        "pathway": " (dme:Dmel_CG5353)",
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        "class_list": "",
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            {
                "id": "6.1.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.3",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0004829 threonine-tRNA ligase activity;GO:0002161 aminoacyl-tRNA deacylase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion",
        "go_biological_process": "GO:0006435 threonyl-tRNA aminoacylation",
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    },
    {
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                "id": "TAD12_DROME",
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        ],
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        "protein_name": "Transcriptional adapter 1-2",
        "gene_name": "Ada1-2",
        "organism": "Fruit fly",
        "refseq_name": "transcriptional adaptor 1-2",
        "refseq_ac": [
            {
                "id": "NP_723703",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_723703",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Ada1-2; Ada1; Ada2; CG31866",
        "gene_names_refseq": "Ada1-2; Ada1; Ada2; CG31866; Dmel\\CG31866; ada1-2; dAda1",
        "protein_names_uniprotkb": "Transcriptional adapter 1-2",
        "protein_names_refseq": "Ada1-2-PA; CG31866-PA; transcriptional adaptor 1-2",
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        "publication_id_list": "10731132;12537572;16980620;21764853;24493646;30559249",
        "class_list": "",
        "function": "Component of the transcription regulatory complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination (PubMed:16980620, PubMed:21764853, PubMed:24493646, PubMed:30559249). The SAGA complex predominantly acetylates histone H3 (PubMed:30559249)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
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        "go_molecular_function": "GO:0003713 transcription coactivator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000124 SAGA complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IPC5-1",
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            {
                "id": "Q8IPC5_DROME",
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            }
        ],
        "mass": 72128.0,
        "length": 639,
        "protein_name": "ubiquitinyl hydrolase 1",
        "gene_name": "CYLD",
        "organism": "Fruit fly",
        "refseq_name": "cylindromatosis, isoform E",
        "refseq_ac": [
            {
                "id": "NP_609371",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609371",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CYLD; CG5603; Cyld; Dmel\\CG5603; Dmel_CG5603; Q8IPC5; cyld; dCYLD",
        "gene_names_refseq": "CG5603; CYLD; Cyld; Dmel\\CG5603; Q8IPC5; cyld; dCYLD",
        "protein_names_uniprotkb": "ubiquitinyl hydrolase 1; 3.4.19.12",
        "protein_names_refseq": "CG5603-PE; CYLD-PE; cylindromatosis ortholog; cylindromatosis, isoform E",
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        ],
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        "protein_name": "Haematopoietic stem/progenitor cell protein 300, isoform A; Haematopoietic stem/progenitor cell protein 300, isoform B",
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        "protein_names_refseq": "CG30173-PB; HSPC300-PB; haematopoietic stem/progenitor cell protein 300, isoform B; syntaxin interacting protein 1",
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        "missing_score": 10000,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "D5A7K1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0044877 protein-containing complex binding",
        "go_cellular_component": "GO:0005856 cytoskeleton;GO:0031209 SCAR complex",
        "go_biological_process": "GO:0021551 central nervous system morphogenesis;GO:0008064 regulation of actin polymerization or depolymerization;GO:0007015 actin filament organization;GO:0008360 regulation of cell shape;GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q8MLQ0-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8MSW4-1",
        "uniprot_id": [
            {
                "id": "METL5_DROME",
                "url": "https://www.uniprot.org/uniprot/Q8MSW4",
                "type": "external"
            }
        ],
        "mass": 23978.0,
        "length": 213,
        "protein_name": "rRNA N(6)-adenosine-methyltransferase Mettl5",
        "gene_name": "Mettl5",
        "organism": "Fruit fly",
        "refseq_name": "methyltransferase like 5, isoform D",
        "refseq_ac": [
            {
                "id": "NP_001137973",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137973",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Mettl5; CG9666",
        "gene_names_refseq": "CG9666; Dmel\\CG9666; Dromel_CG9666_FBtr0074991_mORF; Mettl5",
        "protein_names_uniprotkb": "rRNA N(6)-adenosine-methyltransferase Mettl5; 2.1.1.-; Methyltransferase-like protein 5",
        "protein_names_refseq": "CG9666-PD; Mettl5-PD; methyltransferase like 5, isoform D",
        "tax_id": 7227,
        "disease": "autosomal recessive intellectual developmental disorder 72 (Disease Ontology:DOID:0080765)",
        "pathway": " (dme:Dmel_CG9666)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "10731132;12537569;12537572;32350990",
        "class_list": "",
        "function": "Catalytic subunit of a heterodimer with Trmt112, which specifically methylates the 6th position of adenine in 18S rRNA., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "Q9VVX7",
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            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0008988 rRNA (adenine-N6-)-methyltransferase activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0031167 rRNA methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q8MSW4-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8SYK4-1",
        "uniprot_id": [
            {
                "id": "BOUR_DROME",
                "url": "https://www.uniprot.org/uniprot/Q8SYK4",
                "type": "external"
            }
        ],
        "mass": 16269.0,
        "length": 144,
        "protein_name": "Protein bourbon",
        "gene_name": "bbn",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_652254",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_652254",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "bbn; CG14545",
        "gene_names_refseq": "BcDNA:RE55691; CG14545; Dmel\\CG14545",
        "protein_names_uniprotkb": "Protein bourbon",
        "protein_names_refseq": "CG14545-PA; uncharacterized protein",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG14545)",
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        "publication_count": 4,
        "publication_id_list": "10731132;12537569;12537572;40215271",
        "class_list": "",
        "function": "Part of a complex with Mycbp and otu (PubMed:40215271). Essential for female fertility; involved in germ cell proliferation and germ cell differentiation (PubMed:40215271)., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "secondary_ac_list": "Q9VBL4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0019099 female germ-line sex determination",
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        "hit_score": 0.5,
        "record_id": "Q8SYK4-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8T0Q4-1",
        "uniprot_id": [
            {
                "id": "CHM4_DROME",
                "url": "https://www.uniprot.org/uniprot/Q8T0Q4",
                "type": "external"
            }
        ],
        "mass": 25444.0,
        "length": 226,
        "protein_name": "Charged multivesicular body protein 4",
        "gene_name": "shrb",
        "organism": "Fruit fly",
        "refseq_name": "shrub",
        "refseq_ac": [
            {
                "id": "NP_610462",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610462",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "shrb; CG8055; Shrub; Snf7; Vps32",
        "gene_names_refseq": "CG8055; CHMP4C; DmSNF2; Dmel\\CG8055; Dvps32; ESCRT-III; ESCRT; Shrb; Shrub; Snf7/Vps32; Snf7; Vps32; anon-WO0118547.180; shrb; vps32/snf7; vps32",
        "protein_names_uniprotkb": "Charged multivesicular body protein 4; CHMP4; ESCRT-III complex core component shrb; Protein Shrub",
        "protein_names_refseq": "CG8055-PA; Vps32; shrb-PA; shrub",
        "tax_id": 7227,
        "disease": "cataract 31 multiple types (Disease Ontology:DOID:0110265)",
        "pathway": " (dme:Dmel_CG8055);  (R-DME-1632852);  (R-DME-917729);  (R-DME-9668328)",
        "pathway_count": 4,
        "publication_count": 12,
        "publication_id_list": "10731132;12537572;16713958;22162134;22389409;25647097;25804739;27452459;28564595;33349255;33660341;37226981",
        "class_list": "",
        "function": "Probable core polymerization component of the endosomal sorting required for transport (ESCRT) III complex involved in multiple cellular processes requiring the outward bending of membranes, including vesicle budding, membrane repair and cytokinesis (Probable). The ESCRT pathway involves 4 complexes (ESCRT-0, -I, -II and -III) that sequentially assemble on the cytoplasmic side of membranes and induce membrane remodeling, budding and scission. As part of the ESCRT-III complex, involved in the budding of intraluminal vesicles (ILVs) into endosomes to form multivesicular bodies (MVBs), which target their contents for degradation via the endolysosomal pathway (PubMed:16713958). Involved in regulation of signal transduction pathways, including the Notch and BMP/decapentaplegic (dpp) pathways, by sequestering the intracellular domains of activated receptors into ILVs, isolating them from the cytoplasm and targeting them for lysosomal degradation (PubMed:22162134, PubMed:25804739). Involved in targeting ubiquitilated proteins, such as mono-ubiquitilanated N/Notch, to MVBs for degradation (PubMed:22162134, PubMed:33660341). Plays a role in wing development by regulating Notch signaling (PubMed:22162134). Involved in abscission of germline cells during oogenesis (PubMed:25647097). Involved in spermiogenesis (PubMed:33660341). Required for efficient cytoplasmic isolation and abscission during cytokinesis of epithelial sensory organ precursor cells (PubMed:37226981). May be involved in septate junction remodeling and maintenance (PubMed:37226981)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 2,
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        "reported_mutagensis": 8,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9V543",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005635 nuclear envelope;GO:0043025 neuronal cell body;GO:0009898 cytoplasmic side of plasma membrane;GO:0030496 midbody",
        "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0036258 multivesicular body assembly;GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0016322 neuron remodeling;GO:0006914 autophagy",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q8T0Q4-1",
        "record_type": "protein",
        "filter_code": "0000000.0100111.100000.000000100000000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q94533-1",
        "uniprot_id": [
            {
                "id": "Q94533_DROME",
                "url": "https://www.uniprot.org/uniprot/Q94533",
                "type": "external"
            }
        ],
        "mass": 55427.0,
        "length": 490,
        "protein_name": "Ribosomal protein S6 kinase",
        "gene_name": "S6k",
        "organism": "Fruit fly",
        "refseq_name": "ribosomal protein S6 kinase, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001261450",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261450",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "S6k; 10539; 7-10; 7084; CG10539; DS6K; Dmel\\CG10539; Dmel_CG10539; Dp70S6k; Dp70[s6k]; Dp70s6k; Pk64F; Pk?6; S6 K; S6K1; S6K; S6; d-S6K; dP70S6K; dS6K1; dS6K; dS6k; dp70[S6k]; dp70s6k; dps6k; ds6k; fs(3)07084; l(3)07084; p-S6K; p70 S6K; p70S6K; p70S6k; p70[S6 kinase]; p70[S6K]; p70[S6k]; p70[S6kinase]; p70s6K; pS6K; s6k11; s6k",
        "gene_names_refseq": "10539; 7-10; 7084; CG10539; DS6K; Dmel\\CG10539; Dp70S6k; Dp70[s6k]; Dp70s6k; Pk64F; Pk?6; S6 K; S6K1; S6K; S6k; S6; d-S6K; dP70S6K; dS6K1; dS6K; dS6k; dp70[S6k]; dp70s6k; dps6k; ds6k; fs(3)07084; l(3)07084; p-S6K; p70 S6K; p70/S6K; p70S6K; p70S6k; p70[S6 kinase]; p70[S6K]; p70[S6k]; p70[S6kinase]; p70s6K; pS6K; s6k11; s6k",
        "protein_names_uniprotkb": "Ribosomal protein S6 kinase; 2.7.11.1",
        "protein_names_refseq": "CG10539-PB; RPS6-p70-protein kinase; S6-kinase; S6K kinase; S6k-PB; S6kinase; dS6 kinase; p70 S6 kinase 1; p70 S6 kinase; p70 ribosomal S6 kinase; p70S6 kinase; p70S6K kinase; protein kinase-like 64F; ribosomal S6 protein kinase; ribosomal protein S6 kinase, isoform B; ribosomal protein S6 kinase",
        "tax_id": 7227,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741); primary biliary cholangitis (Disease Ontology:DOID:12236); dilated cardiomyopathy (Disease Ontology:DOID:12930); hyperinsulinism (Disease Ontology:DOID:2018); colon cancer (Disease Ontology:DOID:219); glucose metabolism disease (Disease Ontology:DOID:4194); myocardial infarction (Disease Ontology:DOID:5844); muscular atrophy (Disease Ontology:DOID:767); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (dme:Dmel_CG10539);  (R-DME-166208);  (R-DME-198693)",
        "pathway_count": 3,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "",
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "2.7.11.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "2.7.11.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21",
                "type": "external"
            },
            {
                "id": "5.6.1.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8",
                "type": "external"
            },
            {
                "id": "2.7.11.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "5.2.1.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "2.7.11.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25",
                "type": "external"
            },
            {
                "id": "2.7.11.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12",
                "type": "external"
            },
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "2.7.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-",
                "type": "external"
            },
            {
                "id": "2.7.11.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004711 ribosomal protein S6 kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding",
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        "go_biological_process": "GO:0006979 response to oxidative stress;GO:0030307 positive regulation of cell growth;GO:0032869 cellular response to insulin stimulus;GO:0051124 synaptic assembly at neuromuscular junction;GO:0055088 lipid homeostasis",
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    },
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        ],
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        "protein_name": "Uncharacterized protein",
        "gene_name": "Dmel\\CG3706",
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        "refseq_name": "uncharacterized protein",
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            {
                "id": "NP_652634",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_652634",
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            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG3706; CG3706; Dmel_CG3706; EG:BAC7A4.20; EG:BACR7A4.20; ESTS:99F6T",
        "gene_names_refseq": "CG3706; Dmel\\CG3706; EG:BAC7A4.20; EG:BACR7A4.20; ESTS:99F6T",
        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG3706-PA; uncharacterized protein",
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    },
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        ],
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        "length": 267,
        "protein_name": "Tetraspanin",
        "gene_name": "Tsp66E",
        "organism": "Fruit fly",
        "refseq_name": "tetraspanin 66E, isoform A",
        "refseq_ac": [
            {
                "id": "NP_523985",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523985",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Tsp66E; CG4999; Dm.Tsp66E; Dmel\\CG4999; Dmel_CG4999; tsp66E",
        "gene_names_refseq": "CG4999; Dm.Tsp66E; Dmel\\CG4999; Tsp66E; tsp66E",
        "protein_names_uniprotkb": "Tetraspanin",
        "protein_names_refseq": "CG4999-PA; Tsp66E-PA; tetraspanin 66E, isoform A",
        "tax_id": 7227,
        "disease": "prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); breast carcinoma (Disease Ontology:DOID:3459); cervical squamous cell carcinoma (Disease Ontology:DOID:3744)",
        "pathway": " (dme:Dmel_CG4999);  (R-DME-446107)",
        "pathway_count": 2,
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    },
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        ],
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        "protein_name": "Pyrroline-5-carboxylate reductase",
        "gene_name": "P5cr",
        "organism": "Fruit fly",
        "refseq_name": "pyrroline 5-carboyxlate reductase",
        "refseq_ac": [
            {
                "id": "NP_524400",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524400",
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            }
        ],
        "gene_names_uniprotkb": "P5cr; CG6009; Dmel\\CG6009; Dmel_CG6009; P5CR",
        "gene_names_refseq": "CG6009; Dmel\\CG6009; P5CR; P5cr",
        "protein_names_uniprotkb": "Pyrroline-5-carboxylate reductase; 1.5.1.2",
        "protein_names_refseq": "CG6009-PA; P5cr-PA; pyrroline 5-carboxylate; pyrroline 5-carboyxlate reductase; reductase",
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        "go_cellular_component": "GO:0005739 mitochondrion;GO:1902792 pyrroline-5-carboxylate reductase complex",
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            {
                "id": "RAB5_DROME",
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        ],
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        "protein_name": "Ras-related protein Rab5",
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        "organism": "Fruit fly",
        "refseq_name": "Rab5, isoform G",
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            {
                "id": "NP_001259925",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259925",
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            }
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        "gene_names_uniprotkb": "Rab5; CG3664; RAB5a; Rab",
        "gene_names_refseq": "AAF51265; BAA88244; CG3664; DRab5; Dm Rab5; DmRab5; Dmel\\CG3664; Drab5; RAB5a; RAB5; Rab 5; Rab-5; Rab5; Rab; dRab5; drab5; l(2)k08232; rab5",
        "protein_names_uniprotkb": "Ras-related protein Rab5; 3.6.5.2; Drab5; Small monomeric GTPase Rab5",
        "protein_names_refseq": "CG3664-PG; Rab-protein 5; Rab5, isoform G; Rab5-PG",
        "tax_id": 7227,
        "disease": "cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305); kidney disease (Disease Ontology:DOID:557)",
        "pathway": " (dme:Dmel_CG3664);  (R-DME-1660499);  (R-DME-432722);  (R-DME-6798695);  (R-DME-8854214);  (R-DME-8856828);  (R-DME-8873719);  (R-DME-8876198);  (R-DME-983231)",
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        "publication_id_list": "10731132;11136982;12537569;12537572;12743108;12876219;19050045;23418349;27559127;32391792;35594316;9197407",
        "class_list": "",
        "function": "Small monomeric GTPase which cycles between active GTP-bound and inactive GDP-bound states (Probable). In its active state, binds to a variety of effector proteins to regulate cellular responses such as intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (Probable). Involved in multiple pathways of endocytic transport (Probable). As a critical component of the endocytic trafficking machinery, involved in establishment of morphogen concentration gradients during pattern formation and organogenesis, for example of the TGF-beta homolog dpp/decapentaplegic (PubMed:11136982). Involved in the development and function of the nervous system (PubMed:12743108). Maintains the integrity of endosomes during embryonic development (PubMed:12743108). May be involved in vesicle fusion and budding during synaptic vesicle recycling (PubMed:12743108). Maintains synaptic vesicle size uniformity (important for allowing quantitative release of neurotransmitters), probably by preventing homotypic vesicle fusion (PubMed:12876219). Involved in endosomal trafficking during Ca(2+)-triggered exocytosis at the presynaptic terminal (PubMed:12743108). During oogenesis involved in clathrin-mediated endocytic uptake of yolk proteins and their storage (PubMed:19050045). Required for maturation of early endosomal precursors into mature yolk granules (PubMed:19050045). Associates with endosomal membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns[4,5]P(2)) and mediates its removal (PubMed:19050045). PtdIns[4,5]P(2) removal contributes to endosomal maturation by affecting the ability of PtdIns[4,5]P(2)-binding components of the early endocytic machinery, including factors involved in clathrin recruitment and actin polymerization, to remain associated (PubMed:19050045). Functions upstream of Rab7 in endolysosomal vesicle maturation but not in autolysosomal vesicle maturation (PubMed:27559127). Involved in trafficking and turnover of lysosomal proteins (PubMed:27559127). Stimulates the Rab7 guanyl-nucleotide exchange activity of the Mon1-Ccz1 complex, possibly by recruiting the Mon1-Ccz1 complex to vesicle membranes and enhancing its subsequent recruitment of Rab7 (PubMed:32391792). Involved in wing imaginal disc development (PubMed:35594316)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
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        "ec_number_list": [
            {
                "id": "1.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.-",
                "type": "external"
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            {
                "id": "1.2.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3",
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            },
            {
                "id": "1.-.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-",
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            },
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                "id": "3.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5",
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            },
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                "id": "7.6.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1",
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            },
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                "id": "3.4.23.-",
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                "type": "external"
            },
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            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "3.1.3.56",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
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            },
            {
                "id": "3.6.5.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3",
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            },
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                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
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            },
            {
                "id": "3.1.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2",
                "type": "external"
            },
            {
                "id": "3.4.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-",
                "type": "external"
            },
            {
                "id": "3.4.16.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2",
                "type": "external"
            },
            {
                "id": "3.2.1.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25",
                "type": "external"
            },
            {
                "id": "2.5.1.60",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "3.4.24.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0030234 enzyme regulator activity;GO:0003925 G protein activity",
        "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0043025 neuronal cell body",
        "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0007220 Notch receptor processing;GO:0007399 nervous system development",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q9V3I2-1",
        "record_type": "protein",
        "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
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                "id": "Q9V3I6_DROME",
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            }
        ],
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        "length": 227,
        "protein_name": "BOS complex subunit TMEM147",
        "gene_name": "anon-35Fc",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_609789",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609789",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "anon-35Fc; BG:DS02740.11; CG5861; Dmel\\CG5861; Dmel_CG5861; III; anon-35Fa",
        "gene_names_refseq": "BG:DS02740.11; CG5861; Dmel\\CG5861; III; anon-35Fa; anon-35Fc",
        "protein_names_uniprotkb": "BOS complex subunit TMEM147; Transmembrane protein 147",
        "protein_names_refseq": "CG5861-PA; uncharacterized protein",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG5861)",
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        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
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        ],
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            {
                "id": "NP_649683",
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                "id": "NP_609721",
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        "go_molecular_function": "GO:0001671 ATPase activator activity",
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        "protein_name": "Metabotropic GABA-B receptor subtype 1, isoform B; Metabotropic GABA-B receptor subtype 1, isoform C",
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                "id": "NP_001246033",
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        "protein_names_uniprotkb": "Metabotropic GABA-B receptor subtype 1, isoform B; Metabotropic GABA-B receptor subtype 1, isoform C",
        "protein_names_refseq": "CG15274-PC; GABA-B-R1-PC; metabotropic GABA-B receptor subtype 1, isoform C",
        "tax_id": 7227,
        "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); hypertension (Disease Ontology:DOID:10763); amphetamine abuse (Disease Ontology:DOID:670); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)",
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        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0038039 G protein-coupled receptor heterodimeric complex",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007214 gamma-aminobutyric acid signaling pathway",
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        ],
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        "protein_name": "GPN-loop GTPase",
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        "refseq_name": "uncharacterized protein",
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            {
                "id": "NP_569872",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569872",
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        "gene_names_uniprotkb": "Dmel\\CG3704; CG3704; Dmel_CG3704; EG:BACR7A4.17; XAB1",
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        "protein_names_uniprotkb": "GPN-loop GTPase; 3.6.5.-",
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        "function": "Small GTPase involved in the correct assembly of RNA polymerase II (RNAPII) complex, ensuring proper nuclear import of RNAPII. In vitro, exhibits a chaperone-like activity and a chaperone substrate protein can stimulate its GTPase activity. It is proposed to bind exposed hydrophobic peptide regions of newly synthesized RNAP II subunit, triggering the opening of a hydrophobic pocket in its GDP-bound state. This interaction likely traps exposed hydrophobic regions, preventing misassembly and providing a time window for association with the cognate RNAP II subunit. Peptide binding promotes GDP release, and increasing GTP affinity to facilitate GTP rebinding. Subsequent GTP hydrolysis would then lead to the release of the bound RNAP II subunit to enable association with cognate subunits and RNAP II assembly., [UniProtKB, UniProtKB, UniProtKB]",
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        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "3.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "3.6.5.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
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        "protein_name": "TLC domain-containing protein",
        "gene_name": "Dmel\\CG17841",
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        "gene_names_refseq": "BcDNA:GH12326; CG17841; Dmel\\CG17841; anon-EST:Liang-2.12; clone 2.12",
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        ],
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            {
                "id": "NP_001260073",
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        ],
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VBC4-1",
        "uniprot_id": [
            {
                "id": "WDR20_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VBC4",
                "type": "external"
            }
        ],
        "mass": 95624.0,
        "length": 909,
        "protein_name": "WD repeat-containing protein 20 homolog",
        "gene_name": "Wdr20",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001287545",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287545",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Wdr20; CG6420",
        "gene_names_refseq": "CG6420; Dmel\\CG6420",
        "protein_names_uniprotkb": "WD repeat-containing protein 20 homolog",
        "protein_names_refseq": "CG6420-PB; uncharacterized protein, isoform B",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG6420);  (R-DME-5689880)",
        "pathway_count": 2,
        "publication_count": 4,
        "publication_id_list": "10731132;12537569;12537572;37798281",
        "class_list": "",
        "function": "Regulatory component of the Usp12-46 deubiquitylase complex (PubMed:37798281). This complex deubiquitylates the wg/wingless-signaling receptor arr/arrow, which stabilizes the receptor and increases its concentration at the cell surface; this enhances the sensitivity of cells to wg/wingless-signal stimulation (PubMed:37798281). This increases the amplitude and spatial range of the signaling response to the wg/wingless morphogen gradient, facilitating the precise concentration-dependent regulation of its target genes (PubMed:37798281). Required for wg/wingless-mediated signaling in the wing imaginal disc and for wg/wingless-dependent regulation of intestinal stem cell proliferation (PubMed:37798281)., [UniProtKB, PubMed]",
        "predicted_glycosites": 2,
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        "secondary_ac_list": "Q8T4E0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0035800 deubiquitinase activator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1905368 peptidase complex",
        "go_biological_process": "GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process",
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        "kg_view_protein": true
    },
    {
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            {
                "id": "NEC2_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VBC7",
                "type": "external"
            }
        ],
        "mass": 71733.0,
        "length": 654,
        "protein_name": "Neuroendocrine convertase 2",
        "gene_name": "amon",
        "organism": "Fruit fly",
        "refseq_name": "amontillado",
        "refseq_ac": [
            {
                "id": "NP_477318",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477318",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "amon; CG6438",
        "gene_names_refseq": "Amon; CG6438; DMH#5; Dmel\\CG6438; PC2; PPP; Ppp; amon; dPC2",
        "protein_names_uniprotkb": "Neuroendocrine convertase 2; 3.4.21.94; DMH #5; NEC 2; Prohormone convertase 2; Protein amontillado; dPC2",
        "protein_names_refseq": "CG6438-PA; amon-PA; amontillado; prohormone processing protease",
        "tax_id": 7227,
        "disease": "alcohol use disorder (Disease Ontology:DOID:1574); myocardial infarction (Disease Ontology:DOID:5844); chronic kidney disease (Disease Ontology:DOID:784); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (dme:Dmel_CG6438)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "10436051;10731132;10749852;12537569;12537572;12586710;19559693;20523747;21138435;27628033;28853393;32994163",
        "class_list": "",
        "function": "Serine endopeptidase which is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (PubMed:10749852, PubMed:20523747, PubMed:21138435). Required during embryonic and larval development, probably by proteolytically processing peptide hormones involved in hatching, larval growth and larval molting (PubMed:12586710). Required for the processing and activation of Akh which maintains normal hemolymph sugar levels (PubMed:20523747). Has been shown in one study to be required for processing of sli into slit N-product and slit C-product in the embryo which is necessary for lateral transverse muscle elongation but has been shown in another study not to be required for sli cleavage (PubMed:27628033, PubMed:32994163). Required for larval hatching (PubMed:10436051). Also required for normal larval wandering behavior which occurs prior to pupariation (PubMed:21138435). Required during pupal development for head eversion, leg and wing disk extension, and abdominal differentiation (PubMed:19559693). Required during eye development for R8 photoreceptor cell specification by regulating processing of ligands required for the BMP and activin signaling pathways (PubMed:28853393)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
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        "secondary_ac_list": "Q9UAE7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0017171 serine hydrolase activity;GO:0008233 peptidase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0016020 membrane;GO:0043005 neuron projection",
        "go_biological_process": "GO:0033500 carbohydrate homeostasis;GO:0006508 proteolysis;GO:0016486 peptide hormone processing;GO:0002165 instar larval or pupal development;GO:0045464 R8 cell fate specification",
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    },
    {
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        ],
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        "protein_name": "Beaten path VII",
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        "organism": "Fruit fly",
        "refseq_name": "beaten path VII",
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            {
                "id": "NP_733162",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_733162",
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            }
        ],
        "gene_names_uniprotkb": "beat-VII; Beat-VII; CG14248; CG14249; CG42242; Dmel\\CG42242; Dmel_CG42242; beat VII",
        "gene_names_refseq": "Beat-VII; CG14248; CG14249; CG42242; Dmel\\CG42242; beat VII; beat-VII",
        "protein_names_uniprotkb": "Beaten path VII",
        "protein_names_refseq": "CG42242-PD; beat-VII-PD; beaten path VII",
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        "go_biological_process": "GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules",
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        "length": 256,
        "protein_name": "TweedleD",
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        "organism": "Fruit fly",
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                "id": "NP_651492",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651492",
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            }
        ],
        "gene_names_uniprotkb": "TwdlD; CG14243; Dmel\\CG14243; Dmel_CG14243",
        "gene_names_refseq": "CG14243; Dmel\\CG14243; TwdlD",
        "protein_names_uniprotkb": "TweedleD",
        "protein_names_refseq": "CG14243-PA; TwdlD-PA; TweedleD; tweedle",
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        "protein_names_uniprotkb": "Protein SERAC1",
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        "disease": "3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (Disease Ontology:DOID:0110001)",
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        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0031012 extracellular matrix",
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        "protein_name": "Fructose-bisphosphate aldolase",
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        "tax_id": 7227,
        "disease": "borna disease (Disease Ontology:DOID:5154); hepatocellular carcinoma (Disease Ontology:DOID:684); peritonitis (Disease Ontology:DOID:8283); liver benign neoplasm (Disease Ontology:DOID:916); type 2 diabetes mellitus (Disease Ontology:DOID:9352); hereditary fructose intolerance syndrome (Disease Ontology:DOID:9869)",
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                "id": "3.4.19.-",
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                "id": "3.6.1.5",
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            {
                "id": "3.3.2.6",
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                "id": "2.7.11.22",
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                "id": "2.7.11.23",
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                "id": "3.4.-.-",
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                "id": "3.2.1.-",
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                "id": "1.11.2.-",
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                "id": "NP_001036760",
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        "go_cellular_component": "GO:0005615 extracellular space",
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            {
                "id": "NP_001303484",
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        "gene_names_uniprotkb": "Trmt61; CG14544; Dmel\\CG14544; Dmel_CG14544; TRMT61A",
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        "protein_names_uniprotkb": "tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; 2.1.1.220",
        "protein_names_refseq": "CG14544-PB; Trmt61-PB; tRNA methyltransferase 61, isoform B",
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        "class_list": "",
        "function": "Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries., [UniProtKB, UniProtKB]",
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            {
                "id": "NP_651456",
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        "gene_names_refseq": "CG6092; Cmpk; Dak1L; Dak1; Dm.UMP-CMP kinase; Dmel\\CG6092; UMP-CMPK; anon-WO0118547.320; dak1",
        "protein_names_uniprotkb": "UMP-CMP kinase; 2.7.4.14; CK; Deoxycytidylate kinase; UMP/CMP kinase; UMP/CMPK; Uridine monophosphate/cytidine monophosphate kinase; dCMP kinase",
        "protein_names_refseq": "CG6092-PA; Cmpk-PA; Cytidine/uridine monophosphate kinase 1; Dak1; UMP-CMP kinase",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG6092);  (R-DME-499943)",
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        "class_list": "",
        "function": "Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors., [UniProtKB, HAMAP]",
        "predicted_glycosites": 0,
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            {
                "id": "2.7.4.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14",
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            }
        ],
        "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0005524 ATP binding;GO:0033862 UMP kinase activity;GO:0036430 CMP kinase activity;GO:0036431 dCMP kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion",
        "go_biological_process": "GO:0006139 nucleobase-containing compound metabolic process;GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process;GO:0006225 UDP biosynthetic process;GO:0046705 CDP biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9VBI2-1",
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        "mass": 69917.0,
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        "protein_name": "UBA domain-containing protein",
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            {
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            {
                "id": "NP_651214",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651214",
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        ],
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            {
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        ],
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        "protein_name": "UV excision repair protein RAD23",
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        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_651212",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651212",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG10694; CG10694; Dmel_CG10694",
        "gene_names_refseq": "CG10694; Dmel\\CG10694",
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        "function": "Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair., [UniProtKB, UniProtKB]",
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        "function": "Catalyzes the reduction of fatty acyl-CoA to fatty alcohols., [UniProtKB, UniProtKB]",
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            {
                "id": "NP_651182",
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                "id": "TAF5L_DROME",
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        "protein_name": "Protein will decrease acetylation",
        "gene_name": "wda",
        "organism": "Fruit fly",
        "refseq_name": "will decrease acetylation",
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            {
                "id": "NP_651136",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651136",
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        ],
        "gene_names_uniprotkb": "wda; CG4448",
        "gene_names_refseq": "CG4448; Dmel\\CG4448; WDA; WFA; Wda; dWda; wda",
        "protein_names_uniprotkb": "Protein will decrease acetylation",
        "protein_names_refseq": "CG4448-PA; wda-PA; will decrease acetylation",
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        "disease": "",
        "pathway": " (dme:Dmel_CG4448);  (R-DME-674695);  (R-DME-6804756);  (R-DME-6807505);  (R-DME-73776);  (R-DME-73779);  (R-DME-75953);  (R-DME-76042);  (R-DME-9907900)",
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        "class_list": "",
        "function": "Component of the transcription regulatory complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination (PubMed:16980620, PubMed:20008933, PubMed:21764853, PubMed:24493646, PubMed:30559249). The SAGA complex predominantly acetylates histone H3 (PubMed:30559249). Involved in acetylation of histone H3 on 'Lys-10' (H3K9ac) by the SAGA complex in the larval central nervous system (PubMed:16980620, PubMed:20008933). Involved in SAGA complex coactivator functions (PubMed:20008933, PubMed:34807910). Required for oogenesis (PubMed:34807910)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
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        "go_cellular_component": "GO:0005634 nucleus;GO:0000124 SAGA complex",
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                "id": "NP_651110",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651110",
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        ],
        "gene_names_uniprotkb": "Dmel\\CG6688; CG6688; Dmel_CG6688",
        "gene_names_refseq": "CG6688; Dmel\\CG6688",
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        "protein_name": "Klingon",
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        "protein_names_uniprotkb": "Thyrotropin-releasing hormone receptor; Thyroliberin receptor",
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        "gene_names_refseq": "CG3421; CrGAP; Dmel\\CG3421; RhoGAP93B; RhoGAP; Vilse; rhoGAP93B; vilse",
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        "protein_names_refseq": "CG3421-PA; Rho GTPase activating protein at 93B; RhoGAP93B-PA",
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            {
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        ],
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            {
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        "pathway": " (dme:Dmel_CG18600);  (R-DME-73762);  (R-DME-73772)",
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        "protein_names_refseq": "CG7131-PA; uncharacterized protein",
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        ],
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        "function": "Part of the homotypic fusion and vacuole protein sorting (HOPS) tethering complex involved in endo-lysosomal vesicle trafficking and lysosome biogenesis (PubMed:24554766, PubMed:28063257, PubMed:31194677). The HOPS complex facilitates docking and fusion of lysosomes with late endosomes and several other types of vesicles (PubMed:24554766). The HOPS complex is also involved in autophagy and crinophagy (the elimination of unused secretory granules through their fusion with lysosomes) (PubMed:24554766, PubMed:31194677). The HOPS complex mediates autophagocitic flux, probably by binding autophagosome-associated Syx17/syntaxin 17, promoting assembly of the trans-SNARE complex and instigating autophagosome-lysosome fusion (PubMed:24554766, PubMed:28063257). Independent of Syx17/syntaxin 17, HOPS is involved in biosynthetic transport to lysosomes and lysosome-related organelles such as eye-pigment granules (PubMed:24554766, PubMed:31194677). Required for autophagocytosis-dependent remodeling of myofibrils and transverse-tubules (T-tubules) during metamorphosis (PubMed:28063257)., [UniProtKB, PubMed, PubMed, PubMed]",
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        "go_biological_process": "GO:0097352 autophagosome maturation;GO:0097576 vacuole fusion;GO:0035542 regulation of SNARE complex assembly;GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport",
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        "protein_name": "Hexosaminidase D",
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            {
                "id": "NP_001262699",
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        ],
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        "protein_names_refseq": "CG7985-PB; uncharacterized protein, isoform B",
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        "function": "Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates., [UniProtKB, UniProtKB]",
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        ],
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        "protein_name": "SPRY domain-containing protein",
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            {
                "id": "NP_650673",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650673",
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        ],
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        "protein_names_refseq": "CG7431-PB; TyrR-PB; tyramine receptor, isoform B; tyramine receptor",
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        "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); cardiomyopathy (Disease Ontology:DOID:0050700); congenital nongoitrous hypothyroidism 1 (Disease Ontology:DOID:0070126); ovarian dysgenesis 1 (Disease Ontology:DOID:0080493); nonautoimmune hyperthyroidism (Disease Ontology:DOID:0081101); familial gestational hyperthyroidism (Disease Ontology:DOID:0081102); Graves ophthalmopathy (Disease Ontology:DOID:0081120); familial male-limited precocious puberty (Disease Ontology:DOID:0111545); Leydig cell hypoplasia (Disease Ontology:DOID:0112259); Graves' disease (Disease Ontology:DOID:12361); 46 XX gonadal dysgenesis (Disease Ontology:DOID:14450); breast cancer (Disease Ontology:DOID:1612); gonadal disease (Disease Ontology:DOID:2277); Leydig cell tumor (Disease Ontology:DOID:2696); granulosa cell tumor (Disease Ontology:DOID:2999); serous cystadenocarcinoma (Disease Ontology:DOID:3114); mucinous cystadenocarcinoma (Disease Ontology:DOID:3603); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425); hyperthyroidism (Disease Ontology:DOID:7998); mitral valve prolapse (Disease Ontology:DOID:988)",
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            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG5823; CG5823; Dmel_CG5823",
        "gene_names_refseq": "CG5823; Dmel\\CG5823",
        "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 J2; 2.3.2.23",
        "protein_names_refseq": "CG5823-PB; uncharacterized protein, isoform B",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG5823);  (R-DME-9609523);  (R-DME-983168)",
        "pathway_count": 3,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). In cooperation with the GATOR2 complex, catalyzes 'Lys-6'-linked ubiquitination of NPRL2., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
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        "total_n_glycosites": 0,
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        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "1.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.-",
                "type": "external"
            },
            {
                "id": "1.2.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3",
                "type": "external"
            },
            {
                "id": "1.-.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-",
                "type": "external"
            },
            {
                "id": "2.3.2.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "2.3.2.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31",
                "type": "external"
            },
            {
                "id": "6.2.1.64",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "2.3.2.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34",
                "type": "external"
            },
            {
                "id": "2.3.2.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0036503 ERAD pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9VEJ4-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VEM2-1",
        "uniprot_id": [
            {
                "id": "Q9VEM2_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VEM2",
                "type": "external"
            }
        ],
        "mass": 17455.0,
        "length": 153,
        "protein_name": "Deterin",
        "gene_name": "Det",
        "organism": "Fruit fly",
        "refseq_name": "deterin",
        "refseq_ac": [
            {
                "id": "NP_650608",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650608",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Det; CG12265; Dmel\\CG12265; Dmel_CG12265; det; scpo; svn",
        "gene_names_refseq": "CG12265; Det; Dmel\\CG12265; det; scpo; svn",
        "protein_names_uniprotkb": "Deterin",
        "protein_names_refseq": "CG12265-PA; Det-PA; dSurvivin; deterin; scapolo; survivin",
        "tax_id": 7227,
        "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); ductal carcinoma in situ (Disease Ontology:DOID:0060074); endometrial hyperplasia (Disease Ontology:DOID:0080365); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); transitional cell carcinoma (Disease Ontology:DOID:2671); endometriosis (Disease Ontology:DOID:289); acute pancreatitis (Disease Ontology:DOID:2913); high grade glioma (Disease Ontology:DOID:3070); renal cell carcinoma (Disease Ontology:DOID:4450); stomach carcinoma (Disease Ontology:DOID:5517); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); colorectal cancer (Disease Ontology:DOID:9256)",
        "pathway": " (dme:Dmel_CG12265);  (R-DME-4615885)",
        "pathway_count": 2,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
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        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0051233 spindle midzone;GO:0000775 chromosome, centromeric region;GO:0000776 kinetochore",
        "go_biological_process": "GO:0007059 chromosome segregation;GO:0043066 negative regulation of apoptotic process;GO:0000281 mitotic cytokinesis;GO:0033206 meiotic cytokinesis;GO:0051225 spindle assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9VEM2-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VEP9-1",
        "uniprot_id": [
            {
                "id": "Q9VEP9_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VEP9",
                "type": "external"
            }
        ],
        "mass": 88076.0,
        "length": 784,
        "protein_name": "Splicing factor 3A subunit 1",
        "gene_name": "Sf3a1",
        "organism": "Fruit fly",
        "refseq_name": "splicing factor 3a subunit 1",
        "refseq_ac": [
            {
                "id": "NP_650583",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650583",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Sf3a1; CG16941; Dmel\\CG16941; Dmel_CG16941; SF3A1; SF3a120; SF3a1; l(2)SH3 146; l(3)SH146; sf3a1",
        "gene_names_refseq": "CG16941; Dmel\\CG16941; SF3A1; SF3a120; SF3a1; Sf3a1; l(2)SH3 146; l(3)SH146; sf3a1",
        "protein_names_uniprotkb": "Splicing factor 3A subunit 1",
        "protein_names_refseq": "CG16941-PA; Sf3a1-PA; lethal (3) SH146; splicing factor 3a subunit 1; splicing factor 3a, subunit 1",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG16941);  (R-DME-72163);  (R-DME-9770562);  (R-DME-9943411)",
        "pathway_count": 4,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
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        "total_n_glycosites": 0,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP;GO:0071011 precatalytic spliceosome",
        "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000398 mRNA splicing, via spliceosome;GO:0000381 regulation of alternative mRNA splicing, via spliceosome;GO:0045292 mRNA cis splicing, via spliceosome",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9VEP9-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VEU9-1",
        "uniprot_id": [
            {
                "id": "Q9VEU9_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VEU9",
                "type": "external"
            }
        ],
        "mass": 37687.0,
        "length": 330,
        "protein_name": "Glycerophosphodiester phosphodiesterase 1",
        "gene_name": "Dmel\\CG14883",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_650547",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650547",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG14883; CG14883; Dmel_CG14883",
        "gene_names_refseq": "CG14883; Dmel\\CG14883",
        "protein_names_uniprotkb": "Glycerophosphodiester phosphodiesterase 1",
        "protein_names_refseq": "CG14883-PA; uncharacterized protein",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG14883);  (R-DME-6814848)",
        "pathway_count": 2,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008889 glycerophosphodiester phosphodiesterase activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006580 ethanolamine metabolic process;GO:0070291 N-acylethanolamine metabolic process;GO:0006644 phospholipid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9VEU9-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VEV3-1",
        "uniprot_id": [
            {
                "id": "Q9VEV3_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VEV3",
                "type": "external"
            }
        ],
        "mass": 29402.0,
        "length": 263,
        "protein_name": "Tetratricopeptide repeat protein 1",
        "gene_name": "Ttc1",
        "organism": "Fruit fly",
        "refseq_name": "tetratricopeptide repeat domain 1, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001262636",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262636",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Ttc1; CG14894; Dmel\\CG14894; Dmel_CG14894; dTtc1",
        "gene_names_refseq": "CG14894; Dmel\\CG14894; Ttc1; dTtc1",
        "protein_names_uniprotkb": "Tetratricopeptide repeat protein 1",
        "protein_names_refseq": "CG14894-PB; Ttc1-PB; tetratricopeptide repeat domain 1, isoform B; tetratricopeptide repeat domain 1",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG14894)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "Adapter protein that plays a role downstream of GNA15 to stimulate Ras activation and subsequent phosphorylation of ERK1/2 independently of phospholipase Cbeta signaling. Mechanistically, interacts with GNA15 and SOS2 to form a macromolecular signaling complex which has a high affinity for HRAS. Additionally, participates in signaling via other G-alpha proteins like GNA14, activating NF-kappa-B through Ras and ERK pathways. Beyond signaling, supports protein homeostasis by cooperating with HSP40 in the HSP70 chaperone cycle, promoting protein folding through the regulated dissociation of the HSP70 inhibitor HSPBP1., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9VEV3-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VEV5-1",
        "uniprot_id": [
            {
                "id": "Q9VEV5_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VEV5",
                "type": "external"
            }
        ],
        "mass": 13685.0,
        "length": 113,
        "protein_name": "Small ribosomal subunit protein mS33",
        "gene_name": "mRpS33",
        "organism": "Fruit fly",
        "refseq_name": "mitochondrial ribosomal protein S33",
        "refseq_ac": [
            {
                "id": "NP_524380",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524380",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "mRpS33; CG10406; Dmel\\CG10406; Dmel_CG10406; MRP-S33",
        "gene_names_refseq": "CG10406; Dmel\\CG10406; MRP-S33; mRpS33",
        "protein_names_uniprotkb": "Small ribosomal subunit protein mS33",
        "protein_names_refseq": "CG10406-PA; mRpS33-PA; mitochondrial ribosomal protein S33",
        "tax_id": 7227,
        "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)",
        "pathway": " (dme:Dmel_CG10406);  (R-DME-5389840);  (R-DME-5419276);  (R-DME-9937383)",
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                "id": "NP_650501",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650501",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Argk3; AK-3; CG4546; Dmel\\CG4546; Dmel_CG4546; FBgn0038373",
        "gene_names_refseq": "AK-3; CG4546; Dmel\\CG4546; FBgn0038373",
        "protein_names_uniprotkb": "arginine kinase; 2.7.3.3",
        "protein_names_refseq": "CG4546-PA; arginine kinase 3; uncharacterized protein",
        "tax_id": 7227,
        "disease": "status epilepticus (Disease Ontology:DOID:1824)",
        "pathway": " (dme:Dmel_CG4546)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004111 creatine kinase activity;GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0004054 arginine kinase activity",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0046314 phosphocreatine biosynthetic process;GO:0007320 insemination",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9VF23-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VF28-1",
        "uniprot_id": [
            {
                "id": "Q9VF28_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VF28",
                "type": "external"
            }
        ],
        "mass": 20248.0,
        "length": 177,
        "protein_name": "Actin-related protein 2/3 complex subunit 3",
        "gene_name": "Arpc3A",
        "organism": "Fruit fly",
        "refseq_name": "Actin-related protein 2/3 complex, subunit 3A, isoform C",
        "refseq_ac": [
            {
                "id": "NP_650498",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650498",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Arpc3A; ARC-P21; ARPC; Arpc3a; Arpc3; CG4560; Dmel\\CG4560; Dmel_CG4560",
        "gene_names_refseq": "ARC-P21; ARPC; Arpc3A; Arpc3a; Arpc3; CG4560; Dmel\\CG4560",
        "protein_names_uniprotkb": "Actin-related protein 2/3 complex subunit 3",
        "protein_names_refseq": "Actin-related protein 2/3 complex, subunit 3A, isoform C; Arpc3A-PC; CG4560-PC",
        "tax_id": 7227,
        "disease": "Parkinson's disease (Disease Ontology:DOID:14330); diabetes mellitus (Disease Ontology:DOID:9351)",
        "pathway": " (dme:Dmel_CG4560);  (R-DME-2029482);  (R-DME-3928662);  (R-DME-5663213);  (R-DME-8856828)",
        "pathway_count": 5,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)., [UniProtKB, UniProtKB]; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 0,
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        "total_reported_s_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q29QX5;Q8IND1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton",
        "go_cellular_component": "GO:0005634 nucleus;GO:0015629 actin cytoskeleton;GO:0005885 Arp2/3 protein complex;GO:0042995 cell projection",
        "go_biological_process": "GO:0034314 Arp2/3 complex-mediated actin nucleation;GO:0030833 regulation of actin filament polymerization",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9VF28-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VF33-1",
        "uniprot_id": [
            {
                "id": "Q9VF33_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VF33",
                "type": "external"
            }
        ],
        "mass": 141918.0,
        "length": 1249,
        "protein_name": "Alpha-mannosidase",
        "gene_name": "alpha-Man-IIb",
        "organism": "Fruit fly",
        "refseq_name": "alpha-Mannosidase class II b, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001262614",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262614",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "alpha-Man-IIb; 1; CG4606; DM-GII.2; Dmel\\CG4606; Dmel_CG4606; GM; Man'ase; ManIIb; ManII; alpha-M-II; alpha-Man-II b; dGMIIb",
        "gene_names_refseq": "CG4606; DM-GII.2; Dmel\\CG4606; GM; GTD#24/1; Man'ase; ManIIb; ManII; alpha-M-II; alpha-Man-II b; alpha-Man-IIb; dGMIIb",
        "protein_names_uniprotkb": "Alpha-mannosidase; 3.2.1.-",
        "protein_names_refseq": "CG4606-PB; alpha mannosidase IIb; alpha-D-mannosidase; alpha-Man-IIb-PB; alpha-Mannosidase class II b, isoform B; alpha-mannosidase 2; alpha-mannosidase-IIb; golgi alpha-mannosidase IIb",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG4606);  (R-DME-975578)",
        "pathway_count": 2,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "3.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-",
                "type": "external"
            },
            {
                "id": "3.2.1.114",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.114",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004559 alpha-mannosidase activity;GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity;GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0012505 endomembrane system",
        "go_biological_process": "GO:0006491 N-glycan processing;GO:0006013 mannose metabolic process;GO:1904381 Golgi apparatus N-glycan mannose trimming;GO:0016063 rhodopsin biosynthetic process;GO:0035010 encapsulation of foreign target",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9VF33-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.010000.000000100000000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VF77-1",
        "uniprot_id": [
            {
                "id": "Q9VF77_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VF77",
                "type": "external"
            }
        ],
        "mass": 34291.0,
        "length": 298,
        "protein_name": "Translin associated factor X, isoform B; Translin associated factor X, isoform C",
        "gene_name": "Trax",
        "organism": "Fruit fly",
        "refseq_name": "translin associated factor X, isoform C",
        "refseq_ac": [
            {
                "id": "NP_650454",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650454",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Trax; CG5063; Dmel\\CG5063; Dmel_CG5063; TRAX; trax",
        "gene_names_refseq": "CG5063; Dmel\\CG5063; TRAX; Trax; trax",
        "protein_names_uniprotkb": "Translin associated factor X, isoform B; Translin associated factor X, isoform C",
        "protein_names_refseq": "CG5063-PC; Translin-associated factor X; Trax-PC; translin associated factor X, isoform C",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG5063);  (R-DME-426486)",
        "pathway_count": 2,
        "publication_count": 12,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;21552261;25589440;26109356;26109357",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "Q1W1G2;Q8INE1;Q961W6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0043565 sequence-specific DNA binding;GO:0004521 RNA endonuclease activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q9VF77-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VF85-1",
        "uniprot_id": [
            {
                "id": "Q9VF85_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VF85",
                "type": "external"
            }
        ],
        "mass": 47884.0,
        "length": 417,
        "protein_name": "serine--tRNA ligase",
        "gene_name": "SerRS-m",
        "organism": "Fruit fly",
        "refseq_name": "Seryl-tRNA synthetase, mitochondrial, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001262599",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262599",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SerRS-m; Aat-Ser; Aats-ser; CG4938; DmSRS2; DmSerRS2; Dmel\\CG4938; Dmel_CG4938; SRS; SerRS2; SerRS; dSARS",
        "gene_names_refseq": "Aat-Ser; Aats-ser; CG4938; DmSRS2; DmSerRS2; Dmel\\CG4938; SRS; SerRS-m; SerRS2; SerRS; dSARS",
        "protein_names_uniprotkb": "serine--tRNA ligase; 6.1.1.11; Seryl-tRNA synthetase",
        "protein_names_refseq": "CG4938-PB; SerRS-m-PB; Seryl-tRNA synthetase, mitochondrial, isoform B; seryl-tRNA synthetase",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG4938)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
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        "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0004828 serine-tRNA ligase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0140715 serine-tRNA ligase complex",
        "go_biological_process": "GO:0006434 seryl-tRNA aminoacylation;GO:0070158 mitochondrial seryl-tRNA aminoacylation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
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        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VF86-1",
        "uniprot_id": [
            {
                "id": "Q9VF86_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VF86",
                "type": "external"
            }
        ],
        "mass": 37853.0,
        "length": 348,
        "protein_name": "N-acetyl-D-glucosamine kinase",
        "gene_name": "Nagk",
        "organism": "Fruit fly",
        "refseq_name": "N-acetylglucosamine kinase, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001262598",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262598",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Nagk; CG6218; DNagk; Dmel\\CG6218; Dmel_CG6218",
        "gene_names_refseq": "CG6218; DNagk; Dmel\\CG6218; Nagk",
        "protein_names_uniprotkb": "N-acetyl-D-glucosamine kinase; 2.7.1.59; GlcNAc kinase",
        "protein_names_refseq": "CG6218-PB; N-acetylglucosamine kinase, isoform B; Nagk-PB",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG6218);  (R-DME-446210)",
        "pathway_count": 2,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "2.7.1.59",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.59",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0045127 N-acetylglucosamine kinase activity",
        "go_cellular_component": "",
        "go_biological_process": "GO:0006046 N-acetylglucosamine catabolic process;GO:0006048 UDP-N-acetylglucosamine biosynthetic process;GO:0046835 carbohydrate phosphorylation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
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        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
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    },
    {
        "uniprot_canonical_ac": "Q9VFB5-1",
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            {
                "id": "Q9VFB5_DROME",
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        ],
        "mass": 19107.0,
        "length": 173,
        "protein_name": "DNA-directed RNA polymerase II subunit RPB7",
        "gene_name": "Polr2G",
        "organism": "Fruit fly",
        "refseq_name": "RNA polymerase II subunit G",
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            {
                "id": "NP_731983",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_731983",
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            }
        ],
        "gene_names_uniprotkb": "Polr2G; CG31155; CG6572; Dmel\\CG31155; Dmel_CG31155; RPB7; Rpb7; dRpb7",
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        "protein_names_refseq": "CG31155-PA; Polr2G-PA; RNA polymerase II subunit G; Rpb7",
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        "disease": "cancer (Disease Ontology:DOID:162)",
        "pathway": " (dme:Dmel_CG31155);  (R-DME-112382);  (R-DME-113418);  (R-DME-5578749);  (R-DME-674695);  (R-DME-6781823);  (R-DME-6782135);  (R-DME-6782210);  (R-DME-6796648);  (R-DME-6807505);  (R-DME-72086);  (R-DME-72163);  (R-DME-72165);  (R-DME-72203);  (R-DME-73776);  (R-DME-73779);  (R-DME-75953);  (R-DME-75955);  (R-DME-76042);  (R-DME-77075);  (R-DME-9018519);  (R-DME-9770562)",
        "pathway_count": 22,
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        "go_molecular_function": "GO:0003727 single-stranded RNA binding;GO:0003697 single-stranded DNA binding;GO:0031369 translation initiation factor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000932 P-body;GO:0005665 RNA polymerase II, core complex",
        "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening;GO:0045948 positive regulation of translational initiation",
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    },
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        ],
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        "protein_name": "RING-type E3 ubiquitin transferase",
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        "refseq_name": "Kip1 ubiquitination-promoting complex subunit 1, isoform B",
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            {
                "id": "NP_001247116",
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            }
        ],
        "gene_names_uniprotkb": "Kpc1; CG6752; Dmel\\CG6752; Dmel_CG6752; dKPC1; dKpc1",
        "gene_names_refseq": "CG6752; Dmel\\CG6752; Kpc1; dKPC1; dKpc1",
        "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27",
        "protein_names_refseq": "CG6752-PB; Kip1 ubiquitination-promoting complex subunit 1, isoform B; Kpc1-PB",
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        "pathway": " (dme:Dmel_CG6752);  (R-DME-983168)",
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            {
                "id": "2.3.2.27",
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            },
            {
                "id": "2.3.2.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "2.3.2.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
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            },
            {
                "id": "2.3.2.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34",
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            },
            {
                "id": "2.3.2.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0036126 sperm flagellum;GO:0000151 ubiquitin ligase complex",
        "go_biological_process": "GO:0016567 protein ubiquitination;GO:0051603 proteolysis involved in protein catabolic process;GO:0046693 sperm storage",
        "synthesized_glycan_count": 0,
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    },
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            {
                "id": "Q9VFD9_DROME",
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        "protein_name": "Defective proboscis extension response 9, isoform A; Defective proboscis extension response 9, isoform B",
        "gene_name": "dpr9",
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        "refseq_name": "defective proboscis extension response 9, isoform B",
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            {
                "id": "NP_001287332",
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            }
        ],
        "gene_names_uniprotkb": "dpr9; BcDNA:GH01517; CG12601; CG14862; CG14863; CG31114; CG33485; CT34680; Dmel\\CG33485; Dmel_CG33485; Dpr-9; Dpr9",
        "gene_names_refseq": "BcDNA:GH01517; CG12601; CG14862; CG14863; CG31114; CG33485; CT34680; Dmel\\CG33485; Dpr-9; Dpr9; dpr9",
        "protein_names_uniprotkb": "Defective proboscis extension response 9, isoform A; Defective proboscis extension response 9, isoform B",
        "protein_names_refseq": "CG33485-PB; defective proboscis extension response 9, isoform B; dpr9-PB",
        "tax_id": 7227,
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        ],
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        "protein_name": "Large ribosomal subunit protein uL1",
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            {
                "id": "NP_650410",
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        "gene_names_uniprotkb": "RpL10Aa; BcDNA:AT11516; CG3843; Dmel\\CG3843; Dmel_CG3843; RpL10A; Rpl10Aa",
        "gene_names_refseq": "BcDNA:AT11516; CG3843; Dmel\\CG3843; RpL10Aa; RpL10A; Rpl10Aa",
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        "protein_names_refseq": "CG3843-PA; RpL10Aa-PA; ribosomal protein L10Aa",
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    },
    {
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            {
                "id": "Q9VFE3_DROME",
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            }
        ],
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        "length": 212,
        "protein_name": "V-type proton ATPase 16 kDa proteolipid subunit c",
        "gene_name": "VhaPPA1-1",
        "organism": "Fruit fly",
        "refseq_name": "vacuolar H[+] ATPase PPA1 subunit 1, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001247111",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247111",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "VhaPPA1-1; CG7007; Dmel\\CG7007; Dmel_CG7007; V0c; Vha26; VhaPPA1; vhaPPA1-1",
        "gene_names_refseq": "CG7007; Dmel\\CG7007; V0c''; Vha26; VhaPPA1-1; VhaPPA1; vhaPPA1-1",
        "protein_names_uniprotkb": "V-type proton ATPase 16 kDa proteolipid subunit c; V-type proton ATPase 21 kDa proteolipid subunit c''; Vacuolar proton pump 16 kDa proteolipid subunit c",
        "protein_names_refseq": "CG7007-PB; V-ATPase proton pump; VhaPPA1-1-PB; vacuolar H[+] ATPase PPA1 subunit 1, isoform B; vacuolar H[+] ATPase subunit PPA1-1",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG7007);  (R-DME-1222556);  (R-DME-77387);  (R-DME-917977);  (R-DME-9639288);  (R-DME-983712)",
        "pathway_count": 6,
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        "class_list": "",
        "function": "Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB]",
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        "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism",
        "go_cellular_component": "GO:0016020 membrane;GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0033181 plasma membrane proton-transporting V-type ATPase complex",
        "go_biological_process": "GO:1902600 proton transmembrane transport;GO:0007430 terminal branching, open tracheal system",
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        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
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        "uniprot_id": [
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                "url": "https://www.uniprot.org/uniprot/Q9VFE7",
                "type": "external"
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        ],
        "mass": 90599.0,
        "length": 796,
        "protein_name": "Nuclear pore protein",
        "gene_name": "Nup93-2",
        "organism": "Fruit fly",
        "refseq_name": "nucleoporin 93kD-2",
        "refseq_ac": [
            {
                "id": "NP_650404",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650404",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Nup93-2; CG7262; Cg7262; Dmel\\CG7262; Dmel_CG7262; Nup93-like; Nup93; nup93-2; nup93",
        "gene_names_refseq": "CG7262; Cg7262; Dmel\\CG7262; Nup93-2; Nup93-like; Nup93; nup93-2; nup93",
        "protein_names_uniprotkb": "Nuclear pore protein",
        "protein_names_refseq": "CG7262-PA; Nup93-2-PA; nucleoporin 93kD-2; nucleoporin 93",
        "tax_id": 7227,
        "disease": "nephrotic syndrome type 12 (Disease Ontology:DOID:0080387)",
        "pathway": " (dme:Dmel_CG7262);  (R-DME-159227);  (R-DME-159230);  (R-DME-159231);  (R-DME-159236);  (R-DME-1855170);  (R-DME-1855196);  (R-DME-1855229);  (R-DME-3108214);  (R-DME-3301854);  (R-DME-3371453);  (R-DME-4085377);  (R-DME-4551638);  (R-DME-4615885);  (R-DME-9615933)",
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        "go_molecular_function": "GO:0017056 structural constituent of nuclear pore",
        "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005635 nuclear envelope;GO:0005643 nuclear pore",
        "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006999 nuclear pore organization;GO:0006913 nucleocytoplasmic transport;GO:0006606 protein import into nucleus",
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        ],
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                "id": "NP_650403",
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            }
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            {
                "id": "NP_650401",
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            }
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        "protein_names_uniprotkb": "Mitochondrial-processing peptidase subunit beta; 3.4.24.64; Beta-MPP",
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        "tax_id": 7227,
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        "pathway": " (dme:Dmel_CG3731);  (R-DME-611105);  (R-DME-8949664);  (R-DME-9865881)",
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        "go_biological_process": "GO:0016485 protein processing;GO:0006627 protein processing involved in protein targeting to mitochondrion;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c;GO:1902600 proton transmembrane transport",
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            {
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            }
        ],
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        "length": 711,
        "protein_name": "Short spindle 5",
        "gene_name": "ssp5",
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        "refseq_name": "short spindle 5",
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            {
                "id": "NP_650149",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650149",
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            }
        ],
        "gene_names_uniprotkb": "ssp5; CG14735; Dmel\\CG14735; Dmel_CG14735; Ssp5; Tes59; anon-WO0140519.127",
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            {
                "id": "SPT3_DROME",
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            }
        ],
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        "protein_name": "SAGA complex subunit Spt3",
        "gene_name": "Spt3",
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        "refseq_name": "Spt3",
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            {
                "id": "NP_650146",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650146",
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            }
        ],
        "gene_names_uniprotkb": "Spt3; CG3169",
        "gene_names_refseq": "CG3169; Dmel\\CG3169; SPT3; Spt3; TFIID; dSpt3",
        "protein_names_uniprotkb": "SAGA complex subunit Spt3; Suppressor of Ty protein 3 homolog",
        "protein_names_refseq": "CG3169-PA; Spt3-PA; Spt3",
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        "disease": "",
        "pathway": " (dme:Dmel_CG3169)",
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        "function": "Component of the transcription regulatory complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination (PubMed:12697829, PubMed:16980620, PubMed:18188155, PubMed:21764853, PubMed:24493646, PubMed:30559249). The SAGA complex predominantly acetylates histone H3 (PubMed:12697829, PubMed:30559249). Required for oogenesis; involved in transcriptional activation (PubMed:34807910)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
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        "go_cellular_component": "GO:0005634 nucleus;GO:0000123 histone acetyltransferase complex;GO:0000124 SAGA complex",
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    },
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        ],
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        "gene_name": "KLHL18",
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        "refseq_name": "kelch like family member 18, isoform C",
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            {
                "id": "NP_001262494",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262494",
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            }
        ],
        "gene_names_uniprotkb": "KLHL18; CG3571; Dmel\\CG3571; Dmel_CG3571; anon-WO0118547.179; dKLHL18",
        "gene_names_refseq": "CG3571; Dmel\\CG3571; KLHL18; anon-WO0118547.179; dKLHL18",
        "protein_names_uniprotkb": "Kelch-like protein diablo",
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        "class_list": "",
        "function": "Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May have a role in synapse differentiation and growth., [UniProtKB, UniProtKB, UniProtKB]",
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        ],
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            {
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        ],
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        "protein_names_refseq": "CG10007-PB; Tango9-PB; anon-87Ad; transport and golgi organization 9, isoform B",
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        "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway;GO:0009306 protein secretion;GO:0015780 nucleotide-sugar transmembrane transport",
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        ],
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        "length": 296,
        "protein_name": "Heme oxygenase",
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        "refseq_name": "heme oxygenase",
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            {
                "id": "NP_524321",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524321",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Ho; CG14716; CT34507; DmHO; Dmel\\CG14716; Dmel_CG14716; HO-1; HOX; HO; Ho-1; dHO; ho",
        "gene_names_refseq": "CG14716; CT34507; DmHO; Dmel\\CG14716; HO-1; HOX; HO; Ho-1; Ho; dHO; ho",
        "protein_names_uniprotkb": "Heme oxygenase; 1.14.14.18",
        "protein_names_refseq": "CG14716-PA; Ho-PA; haem oxygenase; heme oxygenase",
        "tax_id": 7227,
        "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); limb ischemia (Disease Ontology:DOID:0050852); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); hepatic veno-occlusive disease (Disease Ontology:DOID:0080177); Parkinsonism (Disease Ontology:DOID:0080855); berylliosis (Disease Ontology:DOID:10322); silicosis (Disease Ontology:DOID:10325); Alzheimer's disease (Disease Ontology:DOID:10652); renal hypertension (Disease Ontology:DOID:1073); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); IgA vasculitis (Disease Ontology:DOID:11123); adult respiratory distress syndrome (Disease Ontology:DOID:11394); sciatic neuropathy (Disease Ontology:DOID:11446); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); factor VIII deficiency (Disease Ontology:DOID:12134); primary biliary cholangitis (Disease Ontology:DOID:12236); varicocele (Disease Ontology:DOID:12337); malaria (Disease Ontology:DOID:12365); retinal ischemia (Disease Ontology:DOID:12510); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); Sjogren's syndrome (Disease Ontology:DOID:12894); intracranial vasospasm (Disease Ontology:DOID:13100); Behcet's disease (Disease Ontology:DOID:13241); pulmonary sarcoidosis (Disease Ontology:DOID:13406); hepatic encephalopathy (Disease Ontology:DOID:13413); toxic shock syndrome (Disease Ontology:DOID:14115); cystic fibrosis (Disease Ontology:DOID:1485); acute chest syndrome (Disease Ontology:DOID:1584); pneumothorax (Disease Ontology:DOID:1673); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316); hemochromatosis (Disease Ontology:DOID:2352); asthma (Disease Ontology:DOID:2841); adenocarcinoma (Disease Ontology:DOID:299); acute kidney failure (Disease Ontology:DOID:3021); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); coronary restenosis (Disease Ontology:DOID:4247); brain edema (Disease Ontology:DOID:4724); esophageal cancer (Disease Ontology:DOID:5041); pulmonary venoocclusive disease (Disease Ontology:DOID:5453); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); peptic ulcer disease (Disease Ontology:DOID:750); abdominal aortic aneurysm (Disease Ontology:DOID:7693); hyperthyroidism (Disease Ontology:DOID:7998); ileus (Disease Ontology:DOID:8440); lung disease (Disease Ontology:DOID:850); hepatopulmonary syndrome (Disease Ontology:DOID:900); acute myeloid leukemia (Disease Ontology:DOID:9119); visceral leishmaniasis (Disease Ontology:DOID:9146); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary emphysema (Disease Ontology:DOID:9675)",
        "pathway": " (dme:Dmel_CG14716)",
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        "ec_number_list": [
            {
                "id": "1.14.14.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004392 heme oxygenase (decyclizing) activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0012505 endomembrane system",
        "go_biological_process": "GO:0006979 response to oxidative stress;GO:0042167 heme catabolic process;GO:0042168 heme metabolic process;GO:0006788 heme oxidation",
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    },
    {
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                "id": "Q9VGN4_DROME",
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        ],
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        "length": 935,
        "protein_name": "Sarcomere length short, isoform B; Sarcomere length short, isoform C",
        "gene_name": "sals",
        "organism": "Fruit fly",
        "refseq_name": "sarcomere length short, isoform B",
        "refseq_ac": [
            {
                "id": "NP_731573",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_731573",
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            }
        ],
        "gene_names_uniprotkb": "sals; CG14703; CG31374; CG6771; Dmel\\CG31374; Dmel_CG31374; Sals",
        "gene_names_refseq": "CG14703; CG31374; CG6771; Dmel\\CG31374; Sals; sals",
        "protein_names_uniprotkb": "Sarcomere length short, isoform B; Sarcomere length short, isoform C",
        "protein_names_refseq": "CG31374-PB; sals-PB; sarcomere length short, isoform B; sarcomere length short",
        "tax_id": 7227,
        "disease": "",
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        "go_molecular_function": "GO:0051015 actin filament binding",
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        "go_biological_process": "GO:0060297 regulation of sarcomere organization;GO:0030838 positive regulation of actin filament polymerization",
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        "kg_view_protein": true
    },
    {
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            {
                "id": "IPO9_DROME",
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        ],
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        "protein_name": "Importin-9",
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            {
                "id": "NP_001287284",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287284",
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            }
        ],
        "gene_names_uniprotkb": "Ipo9; CG5252; Ranbp9",
        "gene_names_refseq": "CG5252; Dmel\\CG5252; Ipo9; RanBP9; Ranbp9",
        "protein_names_uniprotkb": "Importin-9; Ran-binding protein 9",
        "protein_names_refseq": "CG5252-PD; Importin-9; Ipo9-PD; Ranbp9; importin 9, isoform D",
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        "function": "Nuclear transport receptor that mediates nuclear import of proteins (PubMed:33632744). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (By similarity). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (By similarity). Mediates the import of pre-assembled proteasomes into the nucleus during the late stages of sperm development (PubMed:33632744)., [UniProtKB, PubMed, UniProtKB]",
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    },
    {
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            {
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        ],
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        "protein_name": "Large ribosomal subunit protein mL40",
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        "refseq_name": "mitochondrial ribosomal protein L40",
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            {
                "id": "NP_524318",
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        ],
        "gene_names_uniprotkb": "mRpL40; CG5242; Dmel\\CG5242; Dmel_CG5242; MRPL22(24); mRpL22-24",
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        "protein_names_uniprotkb": "Large ribosomal subunit protein mL40; 39S ribosomal protein L40, mitochondrial",
        "protein_names_refseq": "CG5242-PA; mRpL40-PA; mitochondrial ribosomal protein L22/24; mitochondrial ribosomal protein L40",
        "tax_id": 7227,
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        "gene_names_uniprotkb": "KP78a; CG6715; Dmel\\CG6715; Dmel_CG6715; KP78A; Kp78A",
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        "pathway": " (dme:Dmel_CG6715);  (R-DME-5673000);  (R-DME-5674135);  (R-DME-5675221);  (R-DME-9856649)",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8",
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            {
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
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                "id": "2.7.11.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12",
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                "id": "2.7.11.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39",
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        ],
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        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005938 cell cortex",
        "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0000226 microtubule cytoskeleton organization",
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        ],
        "mass": 49924.0,
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        "protein_name": "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial",
        "gene_name": "Dlst",
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        "refseq_name": "uncharacterized protein",
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        "gene_names_uniprotkb": "Dlst; CG5214; Dmel\\CG5214; Dmel_CG5214; GM01350p; Q9VGQ1; alpha-KGDHC",
        "gene_names_refseq": "CG5214; Dmel\\CG5214; GM01350p; Q9VGQ1; alpha-KGDHC",
        "protein_names_uniprotkb": "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; 2-oxoglutarate dehydrogenase complex component E2; 2.3.1.61; E2K",
        "protein_names_refseq": "CG5214-PA; uncharacterized protein",
        "tax_id": 7227,
        "disease": "pheochromocytoma/paraganglioma syndrome 7 (Disease Ontology:DOID:0061222); Alzheimer's disease (Disease Ontology:DOID:10652)",
        "pathway": " (dme:Dmel_CG5214);  (R-DME-6783984);  (R-DME-9853506);  (R-DME-9857492);  (R-DME-9858328)",
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        "class_list": "",
        "function": "Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A., [UniProtKB, UniProtKB]",
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        "ec_number_list": [
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                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2",
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            {
                "id": "1.2.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.-",
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                "id": "2.3.1.61",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.61",
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            {
                "id": "1.8.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4",
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            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
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        ],
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        "go_cellular_component": "GO:0005739 mitochondrion;GO:0030018 Z disc;GO:0045252 oxoglutarate dehydrogenase complex;GO:0160167 oxoadipate dehydrogenase complex",
        "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006103 2-oxoglutarate metabolic process;GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine;GO:0019442 L-tryptophan catabolic process to acetyl-CoA;GO:0120551 2-oxoglutarate decarboxylation to succinyl-CoA",
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        "protein_name": "1.3.-.-; Succinate dehydrogenase, subunit C, isoform A; Succinate dehydrogenase, subunit C, isoform B",
        "gene_name": "SdhC",
        "organism": "Fruit fly",
        "refseq_name": "succinate dehydrogenase, subunit C, isoform B",
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            {
                "id": "NP_001262472",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262472",
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            }
        ],
        "gene_names_uniprotkb": "SdhC; BcDNA:RH04289; C560; CG6666; Dmel\\CG6666; Dmel_CG6666; RH04289p; SDH-C; SDHC; SDH; Sdhc; sdhC",
        "gene_names_refseq": "BcDNA:RH04289; C560; CG6666; Dmel\\CG6666; RH04289p; SDH-C; SDHC; SDH; SdhC; Sdhc; sdhC",
        "protein_names_uniprotkb": "1.3.-.-; Succinate dehydrogenase, subunit C, isoform A; Succinate dehydrogenase, subunit C, isoform B",
        "protein_names_refseq": "CG6666-PB; SdhC-PB; succinate dehydrogenase C; succinate dehydrogenase cytochrome B560 subunit; succinate dehydrogenase, subunit C, isoform B",
        "tax_id": 7227,
        "disease": "paraganglioma (Disease Ontology:DOID:0050773); pheochromocytoma/paraganglioma syndrome 3 (Disease Ontology:DOID:0061218); Carney-Stratakis syndrome (Disease Ontology:DOID:0080533); Leigh disease (Disease Ontology:DOID:3652); lung non-small cell carcinoma (Disease Ontology:DOID:3908); gastrointestinal stromal tumor (Disease Ontology:DOID:9253)",
        "pathway": " (dme:Dmel_CG6666);  (R-DME-71403)",
        "pathway_count": 2,
        "publication_count": 11,
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            {
                "id": "1.3.-.-",
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            }
        ],
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        "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045273 respiratory chain complex II (succinate dehydrogenase)",
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    },
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        ],
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            {
                "id": "NP_001262470",
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            }
        ],
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        "pathway": " (dme:Dmel_CG4772);  (R-DME-9753281);  (R-DME-9757110);  (R-DME-9840309)",
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                "id": "NP_001163585",
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        "protein_names_refseq": "CG4511-PB; uncharacterized protein, isoform B",
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        "protein_names_refseq": "CG4073-PA; uncharacterized protein",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VGY2-1",
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            {
                "id": "Q9VGY2_DROME",
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                "type": "external"
            }
        ],
        "mass": 27120.0,
        "length": 238,
        "protein_name": "Peptide deformylase",
        "gene_name": "CG6482",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform A",
        "refseq_ac": [
            {
                "id": "NP_731494",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_731494",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CG6482; CG31278; Dmel\\CG31278; Dmel_CG31278; PDF",
        "gene_names_refseq": "CG31278; CG6482; Dmel\\CG31278; PDF",
        "protein_names_uniprotkb": "Peptide deformylase; 3.5.1.88",
        "protein_names_refseq": "CG31278-PA; uncharacterized protein, isoform A",
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        "disease": "",
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        "class_list": "",
        "function": "Removes the formyl group from the N-terminal Met of newly synthesized proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
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            {
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.88",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0042586 peptide deformylase activity;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005739 mitochondrion",
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    },
    {
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        ],
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        "protein_name": "DDB1- and CUL4-associated factor 15 WD40 repeat-containing domain-containing protein",
        "gene_name": "Dmel\\CG6325",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_650000",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650000",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG6325; CG6325; Dmel_CG6325",
        "gene_names_refseq": "CG6325; Dmel\\CG6325",
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        "protein_names_refseq": "CG6325-PA; uncharacterized protein",
        "tax_id": 7227,
        "disease": "",
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        ],
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        "length": 64,
        "protein_name": "ATP synthase, epsilon subunit-like, isoform A; ATP synthase, epsilon subunit-like, isoform B; ATP synthase, epsilon subunit-like, isoform C",
        "gene_name": "ATPsynepsilonL",
        "organism": "Fruit fly",
        "refseq_name": "ATP synthase, epsilon subunit-like, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001097736",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097736",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ATPsynepsilonL; ATPE; CG12810; CG31477; Dmel\\CG31477; Dmel_CG31477",
        "gene_names_refseq": "ATPE; ATPsynepsilonL; CG12810; CG31477; Dmel\\CG31477",
        "protein_names_uniprotkb": "ATP synthase, epsilon subunit-like, isoform A; ATP synthase, epsilon subunit-like, isoform B; ATP synthase, epsilon subunit-like, isoform C",
        "protein_names_refseq": "ATP synthase epsilon chain; ATP synthase, epsilon subunit-like, isoform B; ATPsynepsilonL-PB; CG31477-PB",
        "tax_id": 7227,
        "disease": "mitochondrial complex V (ATP synthase) deficiency nuclear type 3 (Disease Ontology:DOID:0060332)",
        "pathway": " (dme:Dmel_CG31477)",
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        "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex",
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    },
    {
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        ],
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        "length": 304,
        "protein_name": "Carbonic anhydrase",
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        "organism": "Fruit fly",
        "refseq_name": "carbonic anhydrase 7, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001287267",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287267",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CAH7; CG3940; Dmel\\CG3940; Dmel_CG3940",
        "gene_names_refseq": "CAH7; CG3940; Dmel\\CG3940",
        "protein_names_uniprotkb": "Carbonic anhydrase; 4.2.1.1",
        "protein_names_refseq": "CAH7-PB; CG3940-PB; carbonic anhydrase 7, isoform B",
        "tax_id": 7227,
        "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome (Disease Ontology:DOID:0050997); colorectal carcinoma (Disease Ontology:DOID:0080199); endometrial hyperplasia (Disease Ontology:DOID:0080365); isolated hyperchlorhidrosis (Disease Ontology:DOID:0111371); retinitis pigmentosa (Disease Ontology:DOID:10584); urinary bladder cancer (Disease Ontology:DOID:11054); lung cancer (Disease Ontology:DOID:1324); hepatitis B (Disease Ontology:DOID:2043); colon adenocarcinoma (Disease Ontology:DOID:234); transitional cell carcinoma (Disease Ontology:DOID:2671); breast carcinoma (Disease Ontology:DOID:3459); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); Lynch syndrome (Disease Ontology:DOID:3883); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); fibrolamellar carcinoma (Disease Ontology:DOID:5015); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (dme:Dmel_CG3940);  (R-DME-1475029)",
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        "class_list": "",
        "function": "Reversible hydration of carbon dioxide., [UniProtKB, UniProtKB]",
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        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform B",
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            {
                "id": "NP_001287263",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287263",
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            }
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        "protein_names_refseq": "CG12948-PB; uncharacterized protein, isoform B",
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        ],
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        "length": 287,
        "protein_name": "2.5.1.16; Spermidine synthase, isoform A; Spermidine synthase, isoform C",
        "gene_name": "SpdS",
        "organism": "Fruit fly",
        "refseq_name": "spermidine synthase, isoform C",
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        "gene_names_refseq": "CG8327; Dmel\\CG8327; SpdS; Spds; spds",
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        "protein_names_refseq": "CG8327-PC; SpdS-PC; spermidine synthase, isoform C",
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        "protein_name": "Iron-sulfur cluster assembly enzyme IscU",
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                "id": "NP_649840",
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        "protein_names_uniprotkb": "Iron-sulfur cluster assembly enzyme IscU; fIscU",
        "protein_names_refseq": "CG9836-PA; Iron-sulfur cluster assembly enzyme; IscU homologue; IscU homolog; IscU-PA",
        "tax_id": 7227,
        "disease": "pre-eclampsia (Disease Ontology:DOID:10591); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); mitochondrial myopathy (Disease Ontology:DOID:699)",
        "pathway": " (dme:Dmel_CG9836);  (R-DME-1362409);  (R-DME-9865881)",
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        "function": "Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins (PubMed:27738674). Component of the mitochondrial core iron-sulfur cluster (ISC) assembly complex; regulates its activity (PubMed:29491838)., [UniProtKB, PubMed, PubMed]",
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        "protein_names_refseq": "CG33720-PB; PFTAIRE-interacting factor 1B, isoform B; Pif1B-PB",
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                "id": "NP_649825",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649825",
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        "protein_names_uniprotkb": "Motif 1 binding protein",
        "protein_names_refseq": "CG9797-PA; M1BP-PA; Motif-1-binding protein; motif 1 binding protein; motif 1-binding protein",
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            {
                "id": "NP_649792",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649792",
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                "id": "NP_609931",
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    },
    {
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            {
                "id": "Q9VJX6_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VJX6",
                "type": "external"
            }
        ],
        "mass": 12471.0,
        "length": 109,
        "protein_name": "Uncharacterized protein",
        "gene_name": "Dmel\\CG42810",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_609657",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609657",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG42810; CG16849; CG42810; Dmel_CG42810",
        "gene_names_refseq": "CG16849; CG42810; Dmel\\CG42810",
        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG42810-PA; uncharacterized protein",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG42810)",
        "pathway_count": 1,
        "publication_count": 11,
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        "record_id": "Q9VJX6-1",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VK29-1",
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            {
                "id": "Q9VK29_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VK29",
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            }
        ],
        "mass": 38821.0,
        "length": 344,
        "protein_name": "Radial spoke head protein 1",
        "gene_name": "Rsph1",
        "organism": "Fruit fly",
        "refseq_name": "radial spoke head protein 1",
        "refseq_ac": [
            {
                "id": "NP_609609",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609609",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Rsph1; CG5458; Dmel\\CG5458; Dmel_CG5458; dRSPH1",
        "gene_names_refseq": "CG5458; Dmel\\CG5458; Rsph1; dRSPH1",
        "protein_names_uniprotkb": "Radial spoke head protein 1",
        "protein_names_refseq": "CG5458-PA; Rsph1-PA; radial spoke head protein 1",
        "tax_id": 7227,
        "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); primary ciliary dyskinesia 24 (Disease Ontology:DOID:0110628)",
        "pathway": " (dme:Dmel_CG5458)",
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        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "",
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        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol",
        "go_biological_process": "GO:0035082 axoneme assembly",
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        "hit_score": 1.2,
        "record_id": "Q9VK29-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VK30-1",
        "uniprot_id": [
            {
                "id": "Q9VK30_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VK30",
                "type": "external"
            }
        ],
        "mass": 45865.0,
        "length": 409,
        "protein_name": "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase",
        "gene_name": "Alg7",
        "organism": "Fruit fly",
        "refseq_name": "Alg7 dolichyl-phosphate N-acetylglucosaminephosphotransferase",
        "refseq_ac": [
            {
                "id": "NP_609608",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609608",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Alg7; CG5287; DPAGT1; Dmel\\CG5287; Dmel_CG5287; dAlg7",
        "gene_names_refseq": "Alg7; CG5287; DPAGT1; Dmel\\CG5287; dAlg7",
        "protein_names_uniprotkb": "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; 2.7.8.15; GlcNAc-1-P transferase; N-acetylglucosamine-1-phosphate transferase",
        "protein_names_refseq": "Alg7 dolichyl-phosphate N-acetylglucosaminephosphotransferase; Alg7-PA; CG5287-PA",
        "tax_id": 7227,
        "disease": "congenital disorder of glycosylation Ij (Disease Ontology:DOID:0080562); congenital myasthenic syndrome 13 (Disease Ontology:DOID:0110676)",
        "pathway": " (dme:Dmel_CG5287);  (R-DME-446193)",
        "pathway_count": 2,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transferring GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "Q961K7",
        "ec_number_list": [
            {
                "id": "2.7.8.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.15",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0016757 glycosyltransferase activity;GO:0003975 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity",
        "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0043541 UDP-N-acetylglucosamine transferase complex",
        "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9VK30-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VK46-1",
        "uniprot_id": [
            {
                "id": "Q9VK46_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VK46",
                "type": "external"
            }
        ],
        "mass": 28199.0,
        "length": 264,
        "protein_name": "Protein YIPF",
        "gene_name": "Yip1d1",
        "organism": "Fruit fly",
        "refseq_name": "Yip1 domain-containing 1",
        "refseq_ac": [
            {
                "id": "NP_609596",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609596",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Yip1d1; CG12404; Dmel\\CG12404; Dmel_CG12404; Yip1",
        "gene_names_refseq": "CG12404; Dmel\\CG12404; Yip1d1; Yip1",
        "protein_names_uniprotkb": "Protein YIPF",
        "protein_names_refseq": "CG12404-PA; Yip1 domain-containing 1; Yip1d1-PA",
        "tax_id": 7227,
        "disease": "azoospermia (Disease Ontology:DOID:14227)",
        "pathway": " (dme:Dmel_CG12404)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
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        "biomarker_type": "",
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        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0070971 endoplasmic reticulum exit site;GO:0005801 cis-Golgi network;GO:0005802 trans-Golgi network",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048280 vesicle fusion with Golgi apparatus;GO:1905808 positive regulation of synapse pruning",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9VK46-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VK47-1",
        "uniprot_id": [
            {
                "id": "Q9VK47_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VK47",
                "type": "external"
            }
        ],
        "mass": 82308.0,
        "length": 743,
        "protein_name": "H(+)-transporting two-sector ATPase",
        "gene_name": "Vha68-3",
        "organism": "Fruit fly",
        "refseq_name": "vacuolar H[+] ATPase 68kD subunit 3",
        "refseq_ac": [
            {
                "id": "NP_609595",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609595",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Vha68-3; CG5075; Dmel\\CG5075; Dmel_CG5075; Vha68; vha67-3; vha68-3",
        "gene_names_refseq": "CG5075; Dmel\\CG5075; Vha68-3; Vha68; vha67-3; vha68-3",
        "protein_names_uniprotkb": "H(+)-transporting two-sector ATPase; 7.1.2.2",
        "protein_names_refseq": "CG5075-PA; V-ATPase V1 subunit A1; Vha68-3-PA; vacuolar H[+] ATPase 68kD subunit 3; vacuolar H[+] ATPase subunit 68-3",
        "tax_id": 7227,
        "disease": "autosomal recessive cutis laxa type IID (Disease Ontology:DOID:0070129); developmental and epileptic encephalopathy 93 (Disease Ontology:DOID:0112275)",
        "pathway": " (dme:Dmel_CG5075)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
        "function": "Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "glyco_site_count": 1,
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        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "7.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0046961 proton-transporting ATPase activity, rotational mechanism",
        "go_cellular_component": "GO:0033180 proton-transporting V-type ATPase, V1 domain;GO:0033176 proton-transporting V-type ATPase complex",
        "go_biological_process": "GO:0046034 ATP metabolic process;GO:1902600 proton transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9VK47-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VK69-1",
        "uniprot_id": [
            {
                "id": "Q9VK69_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VK69",
                "type": "external"
            }
        ],
        "mass": 57116.0,
        "length": 533,
        "protein_name": "T-complex protein 1 subunit delta",
        "gene_name": "CCT4",
        "organism": "Fruit fly",
        "refseq_name": "chaperonin containing TCP1 subunit 4",
        "refseq_ac": [
            {
                "id": "NP_609579",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609579",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CCT4; CG5525; Cct4; Dmel\\CG5525; Dmel_CG5525; Q9VK69_DROME; TCP-1; TCP1-delta; Tcp-1delta; Tcp1-delta; cct4",
        "gene_names_refseq": "CCT4; CG5525; Cct4; Dmel\\CG5525; Q9VK69_DROME; TCP-1; TCP1-delta; Tcp-1delta; Tcp1-delta; cct4",
        "protein_names_uniprotkb": "T-complex protein 1 subunit delta",
        "protein_names_refseq": "CCT4-PA; CG5525-PA; chaperonin containing TCP1 subunit 4",
        "tax_id": 7227,
        "disease": "hereditary sensory and autonomic neuropathy (Disease Ontology:DOID:0050548); intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)",
        "pathway": " (dme:Dmel_CG5525);  (R-DME-390471);  (R-DME-6814122)",
        "pathway_count": 3,
        "publication_count": 11,
        "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357",
        "class_list": "",
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        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0140662 ATP-dependent protein folding chaperone",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005832 chaperonin-containing T-complex",
        "go_biological_process": "GO:0006457 protein folding",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9VK69-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VK82-1",
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            {
                "id": "Q9VK82_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VK82",
                "type": "external"
            }
        ],
        "mass": 88369.0,
        "length": 814,
        "protein_name": "Organic anion transporting polypeptide 33Eb",
        "gene_name": "Oatp33Eb",
        "organism": "Fruit fly",
        "refseq_name": "organic anion transporting polypeptide 33Eb",
        "refseq_ac": [
            {
                "id": "NP_609570",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609570",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Oatp33Eb; CG6417; Dmel\\CG6417; Dmel_CG6417; oatp 33Eb",
        "gene_names_refseq": "CG6417; Dmel\\CG6417; Oatp33Eb; oatp 33Eb",
        "protein_names_uniprotkb": "Organic anion transporting polypeptide 33Eb",
        "protein_names_refseq": "CG6417-PA; Oatp33Eb-PA; organic anion transporting polypeptide 33Eb",
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        "disease": "",
        "pathway": " (dme:Dmel_CG6417);  (R-DME-6798695);  (R-DME-879518)",
        "pathway_count": 3,
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        "ec_number_list": [],
        "go_molecular_function": "GO:0022857 transmembrane transporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016328 lateral plasma membrane",
        "go_biological_process": "GO:0055085 transmembrane transport;GO:0015711 organic anion transport;GO:0043252 sodium-independent organic anion transport",
        "synthesized_glycan_count": 0,
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        "filter_code": "0000000.0000101.100000.000000100000000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VK88-1",
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            {
                "id": "Q9VK88_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VK88",
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            }
        ],
        "mass": 22313.0,
        "length": 192,
        "protein_name": "Uncharacterized protein",
        "gene_name": "BcDNA:AT11334",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001285873",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285873",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "BcDNA:AT11334; CG5435; Dmel\\CG5435; Dmel_CG5435",
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        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG5435-PB; uncharacterized protein, isoform B",
        "tax_id": 7227,
        "disease": "Charcot-Marie-Tooth disease intermediate type (Disease Ontology:DOID:0050543)",
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        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VK90-1",
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            {
                "id": "Q9VK90_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VK90",
                "type": "external"
            }
        ],
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        "protein_name": "Heat shock factor-binding protein 1",
        "gene_name": "BcDNA:RE36920",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform C",
        "refseq_ac": [
            {
                "id": "NP_001260414",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260414",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "BcDNA:RE36920; CG5446; Dmel\\CG5446; Dmel_CG5446",
        "gene_names_refseq": "BcDNA:RE36920; CG5446; Dmel\\CG5446",
        "protein_names_uniprotkb": "Heat shock factor-binding protein 1",
        "protein_names_refseq": "CG5446-PC; uncharacterized protein, isoform C",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG5446);  (R-DME-3371568);  (R-DME-3371571)",
        "pathway_count": 3,
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        "class_list": "",
        "function": "Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
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        "go_molecular_function": "GO:0003714 transcription corepressor activity",
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        "go_biological_process": "GO:0070370 cellular heat acclimation",
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    },
    {
        "uniprot_canonical_ac": "Q9VKA8-1",
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            {
                "id": "Q9VKA8_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VKA8",
                "type": "external"
            }
        ],
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        "length": 265,
        "protein_name": "3.4.21.-; Phaedra 2, isoform B; Phaedra 2, isoform C",
        "gene_name": "Phae2",
        "organism": "Fruit fly",
        "refseq_name": "phaedra 2, isoform C",
        "refseq_ac": [
            {
                "id": "NP_001285871",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285871",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Phae2; CG16997; Dmel\\CG16997; Dmel_CG16997; SP147",
        "gene_names_refseq": "CG16997; Dmel\\CG16997; Phae2; SP147",
        "protein_names_uniprotkb": "3.4.21.-; Phaedra 2, isoform B; Phaedra 2, isoform C",
        "protein_names_refseq": "CG16997-PC; Phae2-PC; Phaedra2; phaedra 2, isoform C",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG16997)",
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        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity",
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        "go_biological_process": "GO:0006508 proteolysis",
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        "record_id": "Q9VKA8-1",
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    },
    {
        "uniprot_canonical_ac": "Q9VKB2-1",
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            {
                "id": "Q9VKB2_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VKB2",
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            }
        ],
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        "length": 724,
        "protein_name": "Ced-12",
        "gene_name": "Ced-12",
        "organism": "Fruit fly",
        "refseq_name": "Ced-12",
        "refseq_ac": [
            {
                "id": "NP_609548",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609548",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Ced-12; CG5336; Ced12; Dced-12; Dmel\\CG5336; Dmel_CG5336; ELMO; Elmo; ced-12; ced12; dCED-12; dCed-12; dCed12; dced-12; dced12; elmo",
        "gene_names_refseq": "CG5336; Ced-12; Ced12; Dced-12; Dmel\\CG5336; ELMO; Elmo; ced-12; ced12; dCED-12; dCed-12; dCed12; dced-12; dced12; elmo",
        "protein_names_uniprotkb": "Ced-12",
        "protein_names_refseq": "CG5336-PA; Ced-12-PA; Ced-12; elmo; engulfment and cell motility",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG5336);  (R-DME-8849471);  (R-DME-9958810)",
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        "class_list": "",
        "function": "Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
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        "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007015 actin filament organization;GO:0016477 cell migration;GO:0046330 positive regulation of JNK cascade;GO:0006909 phagocytosis;GO:0006915 apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q9VKB2-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9VKC7-1",
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            {
                "id": "Q9VKC7_DROME",
                "url": "https://www.uniprot.org/uniprot/Q9VKC7",
                "type": "external"
            }
        ],
        "mass": 59753.0,
        "length": 525,
        "protein_name": "Endoplasmic reticulum lectin 1",
        "gene_name": "Dmel\\CG6766",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_609537",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609537",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG6766; CG6766; Dmel_CG6766; cg6766",
        "gene_names_refseq": "CG6766; Dmel\\CG6766; cg6766",
        "protein_names_uniprotkb": "Endoplasmic reticulum lectin 1; ER lectin",
        "protein_names_refseq": "CG6766-PA; uncharacterized protein",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG6766);  (R-DME-382556);  (R-DME-5358346)",
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        "class_list": "",
        "function": "Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 2,
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        "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0012505 endomembrane system",
        "go_biological_process": "GO:0030968 endoplasmic reticulum unfolded protein response;GO:0030970 retrograde protein transport, ER to cytosol",
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