[ { "uniprot_canonical_ac": "Q9VZ22-1", "uniprot_id": [ { "id": "Q9VZ22_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZ22", "type": "external" } ], "mass": 67900.0, "length": 602, "protein_name": "L(3)mbt interacting protein 1, isoform A; L(3)mbt interacting protein 1, isoform E", "gene_name": "Lint-1", "organism": "Fruit fly", "refseq_name": "l(3)mbt interacting protein 1, isoform E", "refseq_ac": [ { "id": "NP_001285113", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285113", "type": "external" } ], "gene_names_uniprotkb": "Lint-1; CG1908; Dmel\\CG1908; Dmel_CG1908; Lint; dLint-1", "gene_names_refseq": "CG1908; Dmel\\CG1908; Lint-1; Lint; dLint-1", "protein_names_uniprotkb": "L(3)mbt interacting protein 1, isoform A; L(3)mbt interacting protein 1, isoform E", "protein_names_refseq": "CG1908-PE; Lint-1-PE; l(3)mbt interacting protein 1, isoform E", "tax_id": 7227, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005700 polytene chromosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VZ22-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZ30-1", "uniprot_id": [ { "id": "Q9VZ30_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZ30", "type": "external" } ], "mass": 384998.0, "length": 3539, "protein_name": "C2H2-type domain-containing protein", "gene_name": "Dmel\\CG11122", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_572685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572685", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG11122; CG11122; Dmel_CG11122", "gene_names_refseq": "CG11122; Dmel\\CG11122", "protein_names_uniprotkb": "C2H2-type domain-containing protein", "protein_names_refseq": "CG11122-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11122)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;40245499", "class_list": "", "function": "", "predicted_glycosites": 12, "predicted_n_glycosites": 0, "predicted_o_glycosites": 12, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 15, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9VZ30-1", "record_type": "protein", "filter_code": "0000000.0000101.001000.000000100000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZ62-1", "uniprot_id": [ { "id": "Q9VZ62_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZ62", "type": "external" } ], "mass": 78189.0, "length": 671, "protein_name": "Fascetto", "gene_name": "feo", "organism": "Fruit fly", "refseq_name": "fascetto", "refseq_ac": [ { "id": "NP_572658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572658", "type": "external" } ], "gene_names_uniprotkb": "feo; CG11207; Dmel\\CG11207; Dmel_CG11207; EA86; Feo1; Feo; PRC1; Q54; l(1)9Fe; l(1)BP1", "gene_names_refseq": "CG11207; Dmel\\CG11207; EA86; Feo1; Feo; PRC1; Q54; feo; l(1)9Fe; l(1)BP1", "protein_names_uniprotkb": "Fascetto", "protein_names_refseq": "CG11207-PA; fascetto; fasecetto; feo-PA; lethal(1)9Fe", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11207); (R-DME-5625900)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005829 cytosol;GO:0051233 spindle midzone;GO:1990023 mitotic spindle midzone", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization;GO:0007052 mitotic spindle organization;GO:0051256 mitotic spindle midzone assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VZ62-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZ63-1", "uniprot_id": [ { "id": "Q9VZ63_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZ63", "type": "external" } ], "mass": 100574.0, "length": 889, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG2202", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_572657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572657", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG2202; CG2202; Dmel_CG2202", "gene_names_refseq": "CG2202; Dmel\\CG2202", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG2202-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2202)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VZ63-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZ66-1", "uniprot_id": [ { "id": "Q9VZ66_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZ66", "type": "external" } ], "mass": 16781.0, "length": 147, "protein_name": "Uncharacterized protein", "gene_name": "anon-EST:Posey262", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_572654", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572654", "type": "external" } ], "gene_names_uniprotkb": "anon-EST:Posey262; BcDNA:SD22308; CG15209; Dmel\\CG15209; Dmel_CG15209", "gene_names_refseq": "BcDNA:SD22308; CG15209; Dmel\\CG15209; anon-EST:Posey262", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG15209-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15209)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VZ66-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZ72-1", "uniprot_id": [ { "id": "Q9VZ72_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZ72", "type": "external" } ], "mass": 16749.0, "length": 147, "protein_name": "ATP synthase, coupling factor 6-like", "gene_name": "ATPsynCF6L", "organism": "Fruit fly", "refseq_name": "ATP synthase, coupling factor 6-like", "refseq_ac": [ { "id": "NP_647942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647942", "type": "external" } ], "gene_names_uniprotkb": "ATPsynCF6L; ATPR; CG12027; Dmel\\CG12027; Dmel_CG12027", "gene_names_refseq": "ATPR; ATPsynCF6L; CG12027; Dmel\\CG12027", "protein_names_uniprotkb": "ATP synthase, coupling factor 6-like", "protein_names_refseq": "ATP synthase coupling factor 6; ATP synthase, coupling factor 6-like; ATPsynCF6L-PA; CG12027-PA; testis-enriched subunit F6", "tax_id": 7227, "disease": "essential hypertension (Disease Ontology:DOID:10825); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (dme:Dmel_CG12027)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0046034 ATP metabolic process;GO:0015986 proton motive force-driven ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VZ72-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZ79-1", "uniprot_id": [ { "id": "Q9VZ79_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZ79", "type": "external" } ], "mass": 102854.0, "length": 911, "protein_name": "Fibrous sheath CABYR-binding protein", "gene_name": "CG13703", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_729037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_729037", "type": "external" } ], "gene_names_uniprotkb": "CG13703; BcDNA:RE17910; CG13706; CG32237; Dmel\\CG32237; Dmel_CG32237", "gene_names_refseq": "BcDNA:RE17910; CG13703; CG13706; CG32237; Dmel\\CG32237", "protein_names_uniprotkb": "Fibrous sheath CABYR-binding protein", "protein_names_refseq": "CG32237-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32237)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "", "go_biological_process": "GO:0033234 negative regulation of protein sumoylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VZ79-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZA6-1", "uniprot_id": [ { "id": "Q9VZA6_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZA6", "type": "external" } ], "mass": 49021.0, "length": 434, "protein_name": "Hexosyltransferase", "gene_name": "BcDNA:GM04393", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001097505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097505", "type": "external" } ], "gene_names_uniprotkb": "BcDNA:GM04393; CG11357; Dmel\\CG11357; Dmel_CG11357; GalT2; dbeta3GnT", "gene_names_refseq": "BcDNA:GM04393; CG11357; Dmel\\CG11357; GalT2; dbeta3GnT", "protein_names_uniprotkb": "Hexosyltransferase; 2.4.1.-", "protein_names_refseq": "CG11357-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11357)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "glycogene;glycosyltransferase", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016757 glycosyltransferase activity;GO:0008499 N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VZA6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZB5-1", "uniprot_id": [ { "id": "Q9VZB5_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZB5", "type": "external" } ], "mass": 67390.0, "length": 629, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG11349", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_647908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647908", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG11349; CG11349; Dmel_CG11349", "gene_names_refseq": "CG11349; Dmel\\CG11349", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG11349-PB; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11349)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F7VJR4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VZB5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZB7-1", "uniprot_id": [ { "id": "Q9VZB7_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZB7", "type": "external" } ], "mass": 11726.0, "length": 106, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG15024", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_652336", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_652336", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG15024; CG15024; Dmel_CG15024", "gene_names_refseq": "CG15024; Dmel\\CG15024", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG15024-PB; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15024)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VZB7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZE4-1", "uniprot_id": [ { "id": "Q9VZE4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZE4", "type": "external" } ], "mass": 52453.0, "length": 470, "protein_name": "RRM domain-containing protein", "gene_name": "cg1316", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_647887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647887", "type": "external" } ], "gene_names_uniprotkb": "cg1316; CG1316; Dmel\\CG1316; Dmel_CG1316", "gene_names_refseq": "CG1316; Dmel\\CG1316; cg1316", "protein_names_uniprotkb": "RRM domain-containing protein", "protein_names_refseq": "CG1316-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1316)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VZE4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZF6-1", "uniprot_id": [ { "id": "Q9VZF6_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZF6", "type": "external" } ], "mass": 51162.0, "length": 457, "protein_name": "Sulfide:quinone oxidoreductase, mitochondrial", "gene_name": "Sqor", "organism": "Fruit fly", "refseq_name": "sulfide quinone oxidoreductase, isoform A", "refseq_ac": [ { "id": "NP_647877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647877", "type": "external" } ], "gene_names_uniprotkb": "Sqor; BcDNA:GH04863; CG14997; Dmel\\CG14997; Dmel_CG14997", "gene_names_refseq": "BcDNA:GH04863; CG14997; Dmel\\CG14997; Sqor", "protein_names_uniprotkb": "Sulfide:quinone oxidoreductase, mitochondrial; 1.8.5.8; Sulfide quinone oxidoreductase", "protein_names_refseq": "CG14997-PA; Sqor-PA; sulfide quinone oxidoreductase, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14997); (R-DME-1614517)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro). 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CG15008; DmelCpr64Ac; Dmel\\CG15008; Dmel_CG15008", "gene_names_refseq": "CG15008; Cpr64Ac; DmelCpr64Ac; Dmel\\CG15008", "protein_names_uniprotkb": "Cuticular protein 64Ac", "protein_names_refseq": "CG15008-PA; Cpr64Ac-PA; cuticular protein 64Ac", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15008)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008010 structural constituent of chitin-based larval cuticle", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0062129 chitin-based extracellular matrix", "go_biological_process": "GO:0040003 chitin-based cuticle development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VZG0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZG1-1", "uniprot_id": [ { "id": "Q9VZG1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZG1", "type": "external" } ], "mass": 12458.0, "length": 120, "protein_name": "Cuticular protein 64Ab", "gene_name": "Cpr64Ab", "organism": "Fruit fly", "refseq_name": "cuticular protein 64Ab", "refseq_ac": [ { "id": "NP_647873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647873", "type": "external" } ], "gene_names_uniprotkb": "Cpr64Ab; 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CG12020; Dmel_CG12020", "gene_names_refseq": "CG12020; Dmel\\CG12020", "protein_names_uniprotkb": "J domain-containing protein", "protein_names_refseq": "CG12020-PA; uncharacterized protein", "tax_id": 7227, "disease": "primary ciliary dyskinesia 34 (Disease Ontology:DOID:0110610)", "pathway": " (dme:Dmel_CG12020)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W083-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W096-1", "uniprot_id": [ { "id": "Q9W096_DROME", "url": "https://www.uniprot.org/uniprot/Q9W096", "type": "external" } ], "mass": 56497.0, "length": 504, "protein_name": "Phosphatidylinositol-glycan biosynthesis class W protein", "gene_name": "PIG-Wb", "organism": "Fruit fly", "refseq_name": "phosphatidylinositol glycan anchor biosynthesis class W b, isoform B", "refseq_ac": [ { "id": "NP_001261279", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261279", "type": "external" } ], "gene_names_uniprotkb": "PIG-Wb; CG18173; Dmel\\CG18173; Dmel_CG18173; PIG-W; PIGWb", "gene_names_refseq": "CG18173; Dmel\\CG18173; PIG-Wb; PIG-W; PIGWb", "protein_names_uniprotkb": "Phosphatidylinositol-glycan biosynthesis class W protein; 2.3.-.-", "protein_names_refseq": "CG18173-PB; PIG-Wb-PB; phosphatidylinositol glycan anchor biosynthesis class W b, isoform B", "tax_id": 7227, "disease": "hyperphosphatasia with impaired intellectual development syndrome 5 (Disease Ontology:DOID:0070432)", "pathway": " (dme:Dmel_CG18173); (R-DME-162710)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.-.-", "type": "external" } ], "go_molecular_function": "GO:0032216 glucosaminyl-phosphatidylinositol O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W096-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W0A9-1", "uniprot_id": [ { "id": "Q9W0A9_DROME", "url": "https://www.uniprot.org/uniprot/Q9W0A9", "type": "external" } ], "mass": 33733.0, "length": 294, "protein_name": "Telomere length and silencing protein 1 homolog", "gene_name": "Dmel\\CG7974", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001261273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261273", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG7974; CG7974; Dmel_CG7974", "gene_names_refseq": "CG7974; Dmel\\CG7974", "protein_names_uniprotkb": "Telomere length and silencing protein 1 homolog", "protein_names_refseq": "CG7974-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7974); (R-DME-72163)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W0A9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W0B3-1", "uniprot_id": [ { "id": "Q9W0B3_DROME", "url": "https://www.uniprot.org/uniprot/Q9W0B3", "type": "external" } ], "mass": 34458.0, "length": 316, "protein_name": "Vacuolar protein sorting-associated protein VTA1 homolog", "gene_name": "Vta1", "organism": "Fruit fly", "refseq_name": "vesicle trafficking 1", "refseq_ac": [ { "id": "NP_647640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647640", "type": "external" } ], "gene_names_uniprotkb": "Vta1; CG7967; Dmel\\CG7967; Dmel_CG7967", "gene_names_refseq": "CG7967; Dmel\\CG7967; Vta1", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein VTA1 homolog", "protein_names_refseq": "CG7967-PA; Vta1-PA; vesicle trafficking 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7967)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005771 multivesicular body;GO:1990621 ESCRT IV complex", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0090148 membrane fission;GO:0032509 endosome transport via multivesicular body sorting pathway;GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W0B3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W0B8-1", "uniprot_id": [ { "id": "Q9W0B8_DROME", "url": "https://www.uniprot.org/uniprot/Q9W0B8", "type": "external" } ], "mass": 139329.0, "length": 1234, "protein_name": "Coatomer subunit alpha", "gene_name": "alphaCOP", "organism": "Fruit fly", "refseq_name": "coat protein (coatomer) alpha, isoform A", "refseq_ac": [ { "id": "NP_477395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477395", "type": "external" } ], "gene_names_uniprotkb": "alphaCOP; CG7961; Dmel\\CG7961; Dmel_CG7961; alpha-COP; alpha-Cop; alphaCop", "gene_names_refseq": "CG7961; Dmel\\CG7961; alpha-COP; alphaCOP; alphaCop", "protein_names_uniprotkb": "Coatomer subunit alpha", "protein_names_refseq": "CG7961-PA; COPI alpha subunit; alpha-coatomer protein; alphaCOP-PA; coat protein (coatomer) alpha, isoform A; coatomer I", "tax_id": 7227, "disease": "autoimmune interstitial lung, joint, and kidney disease (Disease Ontology:DOID:0081242)", "pathway": " (dme:Dmel_CG7961); (R-DME-6807878); (R-DME-6811434)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors., [UniProtKB, UniProtKB]; Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, 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Aqp17662; CG17662; Dmel\\CG17662; Dmel_CG17662; Eglp 3", "gene_names_refseq": "Aqp17662; CG17662; Dmel\\CG17662; Eglp 3; Eglp3", "protein_names_uniprotkb": "Entomoglyceroporin 3", "protein_names_refseq": "CG17662-PB; Eglp3-PB; entomoglyceroporin 3", "tax_id": 7227, "disease": "autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); hypertension (Disease Ontology:DOID:10763); hydrocephalus (Disease Ontology:DOID:10908); primary biliary cholangitis (Disease Ontology:DOID:12236); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); uveitis (Disease Ontology:DOID:13141); retinal vein occlusion (Disease Ontology:DOID:1727); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); brain edema (Disease Ontology:DOID:4724); retinal disease (Disease Ontology:DOID:5679); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); diabetes insipidus (Disease Ontology:DOID:9409)", "pathway": " (dme:Dmel_CG17662); (R-DME-1237044); (R-DME-1247673); (R-DME-432040); (R-DME-432047)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D5SHM3", "ec_number_list": [], "go_molecular_function": "GO:0015267 channel activity;GO:0015250 water channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006833 water transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W1M2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W1Q0-1", "uniprot_id": [ { "id": "Q9W1Q0_DROME", "url": "https://www.uniprot.org/uniprot/Q9W1Q0", "type": "external" } ], "mass": 19188.0, "length": 171, "protein_name": "SKP1-related F", "gene_name": "SkpF", "organism": "Fruit fly", "refseq_name": "SKP1-related F", "refseq_ac": [ { "id": "NP_611796", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611796", "type": "external" } ], "gene_names_uniprotkb": "SkpF; CG12227; Dmel\\CG12227; Dmel_CG12227; Skp; skpF", "gene_names_refseq": "CG12227; Dmel\\CG12227; SkpF; Skp; skpF", "protein_names_uniprotkb": "SKP1-related F", "protein_names_refseq": "CG12227-PA; SKP1-related F; SkpF-PA; skpF", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12227)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0097602 cullin family protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W1Q0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W1R0-1", "uniprot_id": [ { "id": "Q9W1R0_DROME", "url": "https://www.uniprot.org/uniprot/Q9W1R0", "type": "external" } ], "mass": 46381.0, "length": 412, "protein_name": "Yellow-d2", "gene_name": "yellow-d2", "organism": "Fruit fly", "refseq_name": "yellow-d2", "refseq_ac": [ { "id": "NP_611788", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611788", "type": "external" } ], "gene_names_uniprotkb": "yellow-d2; CG9891; CT27880; Dmel\\CG9891; Dmel_CG9891; yel-d2; yellow-D2", "gene_names_refseq": "CG9891; CT27880; Dmel\\CG9891; yel-d2; yellow-D2; yellow-d2", "protein_names_uniprotkb": "Yellow-d2", "protein_names_refseq": "CG9891-PA; yellow-d2-PA; yellow-d2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9891)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W1R0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W1S1-1", "uniprot_id": [ { "id": "Q9W1S1_DROME", "url": "https://www.uniprot.org/uniprot/Q9W1S1", "type": "external" } ], "mass": 105615.0, "length": 912, "protein_name": "Aminopeptidase", "gene_name": "BEST:LD34564", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_611781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611781", "type": "external" } ], "gene_names_uniprotkb": "BEST:LD34564; 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Atlas, isoform B", "gene_name": "atlas", "organism": "Fruit fly", "refseq_name": "atlas, isoform B", "refseq_ac": [ { "id": "NP_001286762", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286762", "type": "external" } ], "gene_names_uniprotkb": "atlas; CG13541; Dmel\\CG13541; Dmel_CG13541; atl", "gene_names_refseq": "CG13541; Dmel\\CG13541; atlas; atl", "protein_names_uniprotkb": "Atlas, isoform A; Atlas, isoform B", "protein_names_refseq": "CG13541-PB; atlas, isoform B; atlas-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13541)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0035092 sperm DNA condensation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W1S6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W1T9-1", "uniprot_id": [ { "id": "Q9W1T9_DROME", "url": "https://www.uniprot.org/uniprot/Q9W1T9", "type": "external" } ], "mass": 104769.0, "length": 922, "protein_name": "Uncharacterized protein", "gene_name": "Ctr9L", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_611764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611764", "type": "external" } ], "gene_names_uniprotkb": "Ctr9L; CG9899; Dmel\\CG9899; Dmel_CG9899; dctr9", "gene_names_refseq": "CG9899; Dmel\\CG9899; dctr9", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG9899-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9899)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042169 SH2 domain binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0000791 euchromatin;GO:0016593 Cdc73/Paf1 complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006368 transcription elongation by RNA polymerase II;GO:0019100 male germ-line sex determination", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W1T9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W1U9-1", "uniprot_id": [ { "id": "Q9W1U9_DROME", "url": "https://www.uniprot.org/uniprot/Q9W1U9", "type": "external" } ], "mass": 8387.0, "length": 88, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG9877", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_611754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611754", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG9877; BcDNA:RE26296; CG9877; Dmel_CG9877", "gene_names_refseq": "BcDNA:RE26296; CG9877; Dmel\\CG9877", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG9877-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9877)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W1U9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W1W4-1", "uniprot_id": [ { "id": "Q9W1W4_DROME", "url": "https://www.uniprot.org/uniprot/Q9W1W4", "type": "external" } ], "mass": 28890.0, "length": 253, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG9896", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_611745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611745", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG9896; CG9896; Dmel_CG9896", "gene_names_refseq": "CG9896; Dmel\\CG9896", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG9896-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9896)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W1W4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W1Z6-1", "uniprot_id": [ { "id": "Q9W1Z6_DROME", "url": "https://www.uniprot.org/uniprot/Q9W1Z6", "type": "external" } ], "mass": 128949.0, "length": 1136, "protein_name": "3.4.24.-; Stall, isoform C; Stall, isoform E", "gene_name": "stl", "organism": "Fruit fly", "refseq_name": "stall, isoform C", "refseq_ac": [ { "id": "NP_001097423", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097423", "type": "external" } ], "gene_names_uniprotkb": "stl; BcDNA:GM08694; CG3622; Dmel\\CG3622; Dmel_CG3622; fs(2)A16", "gene_names_refseq": "BcDNA:GM08694; CG3622; Dmel\\CG3622; fs(2)A16; stl", "protein_names_uniprotkb": "3.4.24.-; Stall, isoform C; Stall, isoform E", "protein_names_refseq": "CG3622-PC; female sterile(2)A16; stall, isoform C; stall; stl-PC", "tax_id": 7227, "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); primary progressive multiple sclerosis (Disease Ontology:DOID:0050784); stroke (Disease Ontology:DOID:0051061); Hennekam syndrome (Disease Ontology:DOID:0060366); Ehlers-Danlos syndrome dermatosparaxis type (Disease Ontology:DOID:0080733); hypertension (Disease Ontology:DOID:10763); cryptorchidism (Disease Ontology:DOID:11383); male infertility (Disease Ontology:DOID:12336); mucopolysaccharidosis VI (Disease Ontology:DOID:12800); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); ureteral obstruction (Disease Ontology:DOID:5199); urinary tract obstruction (Disease Ontology:DOID:5200); myocardial infarction (Disease Ontology:DOID:5844); rheumatoid arthritis (Disease Ontology:DOID:7148); osteoarthritis (Disease Ontology:DOID:8398); degenerative disc disease (Disease Ontology:DOID:90)", "pathway": " (dme:Dmel_CG3622); (R-DME-5173214)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.4.1.221", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.221", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:2001223 negative regulation of neuron migration;GO:0048477 oogenesis;GO:0030707 follicle cell of egg chamber development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W1Z6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W213-1", "uniprot_id": [ { "id": "Q9W213_DROME", "url": "https://www.uniprot.org/uniprot/Q9W213", "type": "external" } ], "mass": 151760.0, "length": 1395, "protein_name": "Roundabout 1, isoform A; Roundabout 1, isoform C", "gene_name": "robo1", "organism": "Fruit fly", "refseq_name": "roundabout 1, isoform A", "refseq_ac": [ { "id": "NP_476899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476899", "type": "external" } ], "gene_names_uniprotkb": "robo1; BEST:GM07780; CG13521; CT32892; D-Robo1; Dmel\\CG13521; Dmel_CG13521; ROBO; Robo-1; Robo1; Robo; dRobo1; dRobo; robo-1; robo1S; robo; roundabout", "gene_names_refseq": "BEST:GM07780; CG13521; CT32892; D-Robo1; Dmel\\CG13521; ROBO; Robo-1; Robo1; Robo; dRobo1; dRobo; robo-1; robo1S; robo1; robo; roundabout", "protein_names_uniprotkb": "Roundabout 1, isoform A; Roundabout 1, isoform C", "protein_names_refseq": "CG13521-PA; robo1-PA; roundabout 1, isoform A; roundabout 1; roundabout", "tax_id": 7227, "disease": "atrial fibrillation (Disease Ontology:DOID:0060224); myoclonic-atonic epilepsy (Disease Ontology:DOID:0060475); combined or isolated pituitary hormone deficiency 8 (Disease Ontology:DOID:0061018); autosomal recessive congenital nystagmus 8 (Disease Ontology:DOID:0061178); polymyositis (Disease Ontology:DOID:0080745); dermatomyositis (Disease Ontology:DOID:10223); pre-eclampsia (Disease Ontology:DOID:10591); lung cancer (Disease Ontology:DOID:1324); transient cerebral ischemia (Disease Ontology:DOID:224); cystic kidney disease (Disease Ontology:DOID:2975); plasmacytoma (Disease Ontology:DOID:3721); lung non-small cell carcinoma (Disease Ontology:DOID:3908); diabetic retinopathy (Disease Ontology:DOID:8947); multiple myeloma (Disease Ontology:DOID:9538); vesicoureteral reflux (Disease Ontology:DOID:9620)", "pathway": " (dme:Dmel_CG13521); (R-DME-376176); (R-DME-428542); (R-DME-428890); (R-DME-9010553)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7KVK3", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0008046 axon guidance receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0031982 vesicle", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0007155 cell adhesion;GO:0016199 axon midline choice point recognition;GO:0030335 positive regulation of cell migration;GO:0046716 muscle cell cellular homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W213-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W226-1", "uniprot_id": [ { "id": "Q9W226_DROME", "url": "https://www.uniprot.org/uniprot/Q9W226", "type": "external" } ], "mass": 17416.0, "length": 153, "protein_name": "LITAF domain-containing protein", "gene_name": "Dmel\\CG30195", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_611696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611696", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG30195; 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CG11170; Dmel\\CG11170; Dmel_CG11170", "gene_names_refseq": "CG11170; CG30279; Dmel\\CG11170", "protein_names_uniprotkb": "FAM69 protein-kinase domain-containing protein", "protein_names_refseq": "CG11170-PC; DIA1 ortholog; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11170)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W280-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W299-1", "uniprot_id": [ { "id": "Q9W299_DROME", "url": "https://www.uniprot.org/uniprot/Q9W299", "type": "external" } ], "mass": 49411.0, "length": 436, "protein_name": "Sugar phosphate phosphatase", "gene_name": "Dmel\\CG11474", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": [ { "id": "NP_611634", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611634", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG11474; CG11474; Dmel_CG11474", "gene_names_refseq": "CG11474; Dmel\\CG11474", "protein_names_uniprotkb": "Sugar phosphate phosphatase; 2.1.1.-; 3.1.3.-", "protein_names_refseq": "CG11474-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11474)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8MLU2", "ec_number_list": [ { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0016462 pyrophosphatase activity;GO:0046872 metal ion binding;GO:0051998 protein carboxyl O-methyltransferase activity;GO:0016791 phosphatase activity", "go_cellular_component": "", "go_biological_process": "GO:0006974 DNA damage response;GO:0032259 methylation;GO:0030643 intracellular phosphate ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W299-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W2A4-1", "uniprot_id": [ { "id": "Q9W2A4_DROME", "url": "https://www.uniprot.org/uniprot/Q9W2A4", "type": "external" } ], "mass": 47692.0, "length": 404, "protein_name": "Gustatory receptor-like 58a", "gene_name": "Grl58a", "organism": "Fruit fly", "refseq_name": "gustatory receptor-like 58a", "refseq_ac": [ { "id": "NP_611630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611630", "type": "external" } ], "gene_names_uniprotkb": "Grl58a; CG13500; Dmel\\CG13500; Dmel_CG13500", "gene_names_refseq": "CG13500; Dmel\\CG13500; Grl58a", "protein_names_uniprotkb": "Gustatory receptor-like 58a", "protein_names_refseq": "CG13500-PA; Grl58a-PA; gustatory receptor-like 58a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13500)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022834 ligand-gated channel activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W2A4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W2I2-1", "uniprot_id": [ { "id": "Q9W2I2_DROME", "url": "https://www.uniprot.org/uniprot/Q9W2I2", "type": "external" } ], "mass": 39545.0, "length": 343, "protein_name": "Queuosine 5'-phosphate N-glycosylase/hydrolase", "gene_name": "Dmel\\CG9752", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_611573", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611573", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG9752; CG9752; Dmel_CG9752", "gene_names_refseq": "CG9752; Dmel\\CG9752", "protein_names_uniprotkb": "Queuosine 5'-phosphate N-glycosylase/hydrolase; 3.2.2.-; Queuosine-nucleotide N-glycosylase/hydrolase", "protein_names_refseq": "CG9752-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9752); (R-DME-6782315)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0106432 queuosine nucleosidase activity", "go_cellular_component": "", "go_biological_process": "GO:0006400 tRNA modification", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W2I2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W2J0-1", "uniprot_id": [ { "id": "Q9W2J0_DROME", "url": "https://www.uniprot.org/uniprot/Q9W2J0", "type": "external" } ], "mass": 39560.0, "length": 338, "protein_name": "Uncharacterized protein", "gene_name": "CG15662", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_611566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611566", "type": "external" } ], "gene_names_uniprotkb": "CG15662; 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17; CG11312; Dmel\\CG11312; Dmel_CG11312; INSC; Insc; Ins; fam; l(2)05475; l(2)k12405; nem", "gene_names_refseq": "25/17; CG11312; Dmel\\CG11312; INSC; Insc; Ins; fam; insc; l(2)05475; l(2)k12405; nem", "protein_names_uniprotkb": "Inscuteable", "protein_names_refseq": "CG11312-PA; fata morgana; insc-PA; inscrutable; inscutable; inscuteable; not enough muscles", "tax_id": 7227, "disease": "Charcot-Marie-Tooth disease type 2 (Disease Ontology:DOID:0050539)", "pathway": " (dme:Dmel_CG11312)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;22171003;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008093 cytoskeletal anchor activity", "go_cellular_component": "GO:0045179 apical cortex;GO:0005737 cytoplasm;GO:0005938 cell cortex;GO:1990499 raps-insc complex", "go_biological_process": "GO:0007525 somatic muscle development;GO:0009786 regulation of asymmetric cell division;GO:0050829 defense response to Gram-negative bacterium;GO:0007422 peripheral nervous system development;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9W2R4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W2S6-1", "uniprot_id": [ { "id": "Q9W2S6_DROME", "url": "https://www.uniprot.org/uniprot/Q9W2S6", "type": "external" } ], "mass": 32586.0, "length": 292, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG12637", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_572645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572645", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG12637; 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8a; CG12665; DmelObp8a; Dmel\\CG12665; Dmel_CG12665; OBP8a", "gene_names_refseq": "8a; CG12665; DmelObp8a; Dmel\\CG12665; OBP8a; Obp8a", "protein_names_uniprotkb": "Odorant-binding protein 8a", "protein_names_refseq": "CG12665-PA; Obp8a-PA; Odorant-binding protein 8a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12665)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005549 odorant binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007608 sensory perception of smell;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W372-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W375-1", "uniprot_id": [ { "id": "Q9W375_DROME", "url": "https://www.uniprot.org/uniprot/Q9W375", "type": "external" } ], "mass": 31764.0, "length": 284, "protein_name": "Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial", "gene_name": "Dmel\\CG12118", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": [ { "id": "NP_572537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572537", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG12118; 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CG32707; CG4350; Dmel\\CG32707; Dmel_CG32707", "gene_names_refseq": "APC4; CG32707; CG4350; Dmel\\CG32707", "protein_names_uniprotkb": "Anaphase-promoting complex subunit 4; Cyclosome subunit 4", "protein_names_refseq": "APC4-PA; CG32707-PA; anaphase promoting complex 4; anaphase promoting complex subunit 4, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32707); (R-DME-141430); (R-DME-174048); (R-DME-174084); (R-DME-174154); (R-DME-174178); (R-DME-174184); (R-DME-176407); (R-DME-176408); (R-DME-176409); (R-DME-176412); (R-DME-179409); (R-DME-2467813); (R-DME-2559582); (R-DME-68867); (R-DME-69017); (R-DME-983168)", "pathway_count": 17, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005680 anaphase-promoting complex;GO:0034399 nuclear periphery", "go_biological_process": "GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle;GO:0016567 protein ubiquitination;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W395-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W3B2-1", "uniprot_id": [ { "id": "Q9W3B2_DROME", "url": "https://www.uniprot.org/uniprot/Q9W3B2", "type": "external" } ], "mass": 40586.0, "length": 343, "protein_name": "Protein MAK16 homolog", "gene_name": "Rbm13", "organism": "Fruit fly", "refseq_name": "RNA-binding motif protein 13, isoform B", "refseq_ac": [ { "id": "NP_001285026", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285026", "type": "external" } ], "gene_names_uniprotkb": "Rbm13; 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Nicotinic acetylcholine receptor alpha3, isoform C", "gene_name": "nAChRalpha3", "organism": "Fruit fly", "refseq_name": "nicotinic acetylcholine receptor alpha3, isoform C", "refseq_ac": [ { "id": "NP_001285015", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285015", "type": "external" } ], "gene_names_uniprotkb": "nAChRalpha3; Acr7E; CG2302; D[a3]; Da3; Dalpha3 nAChR; Dalpha3; Dmel\\CG2302; Dmel_CG2302; alpha3; lincRNA.965; nACRalpha-7E; nAChR; nAcRalpha-7E; nAcRe; nAchRalpha3; nicra3", "gene_names_refseq": "Acr7E; CG2302; D[a3]; Da3; Dalpha3 nAChR; Dalpha3; Dmel\\CG2302; alpha3; lincRNA.965; nACRalpha-7E; nAChRalpha3; nAChR; nAcRalpha-7E; nAcRe; nAchRalpha3; nicra3", "protein_names_uniprotkb": "Nicotinic acetylcholine receptor alpha3, isoform B; Nicotinic acetylcholine receptor alpha3, isoform C", "protein_names_refseq": "CG2302-PC; Dalpha3; drosophila alpha-like subunit 3; nAChRalpha3-PC; nAcRalpha-7E; nicotinic acetylcholine receptor alpha 7E; nicotinic acetylcholine receptor alpha3, isoform C", "tax_id": 7227, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant nocturnal frontal lobe epilepsy (Disease Ontology:DOID:0060681); autosomal dominant nocturnal frontal lobe epilepsy 1 (Disease Ontology:DOID:0060682); autosomal dominant nocturnal frontal lobe epilepsy 3 (Disease Ontology:DOID:0060684); autosomal dominant nocturnal frontal lobe epilepsy 4 (Disease Ontology:DOID:0060685); congenital myasthenic syndrome 1B (Disease Ontology:DOID:0110662); congenital myasthenic syndrome 1A (Disease Ontology:DOID:0110663); congenital myasthenic syndrome 4A (Disease Ontology:DOID:0110678); congenital myasthenic syndrome 4C (Disease Ontology:DOID:0110679); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Lewy body dementia (Disease Ontology:DOID:12217); lung cancer (Disease Ontology:DOID:1324); Parkinson's disease (Disease Ontology:DOID:14330); major depressive disorder (Disease Ontology:DOID:1470); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); bipolar disorder (Disease Ontology:DOID:3312); congenital myasthenic syndrome (Disease Ontology:DOID:3635); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung carcinoma (Disease Ontology:DOID:3905); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); lung large cell carcinoma (Disease Ontology:DOID:4556); lung small cell carcinoma (Disease Ontology:DOID:5409); congestive heart failure (Disease Ontology:DOID:6000); cocaine abuse (Disease Ontology:DOID:809); oral cavity cancer (Disease Ontology:DOID:8618); nasopharynx carcinoma (Disease Ontology:DOID:9261); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (dme:Dmel_CG2302); (R-DME-629587); (R-DME-629594); (R-DME-629597); (R-DME-6798695)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 36, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0042391 regulation of membrane potential;GO:0007268 chemical synaptic transmission;GO:0034220 monoatomic ion transmembrane transport;GO:0006812 monoatomic cation transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W3G6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W3J6-1", "uniprot_id": [ { "id": "Q9W3J6_DROME", "url": "https://www.uniprot.org/uniprot/Q9W3J6", "type": "external" } ], "mass": 33799.0, "length": 301, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG17982", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001285007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285007", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG17982; 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CG4615; Dmel_CG4615", "gene_names_refseq": "CG4615; Dmel\\CG4615", "protein_names_uniprotkb": "Monocyte to macrophage differentiation factor", "protein_names_refseq": "CG4615-PA; uncharacterized protein", "tax_id": 7227, "disease": "systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (dme:Dmel_CG4615)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0140911 pore-forming activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W3S5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W3W0-1", "uniprot_id": [ { "id": "Q9W3W0_DROME", "url": "https://www.uniprot.org/uniprot/Q9W3W0", "type": "external" } ], "mass": 124673.0, "length": 1123, "protein_name": "Inactive", "gene_name": "iav", "organism": "Fruit fly", "refseq_name": "inactive", "refseq_ac": [ { "id": "NP_572353", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572353", "type": "external" } ], "gene_names_uniprotkb": "iav; CG4536; CT14708; DmIav; Dmel\\CG4536; Dmel_CG4536; IAV; Iav; TRPV; hypoB; osm-9", "gene_names_refseq": "CG4536; CT14708; DmIav; Dmel\\CG4536; IAV; Iav; TRPV; hypoB; iav; osm-9", "protein_names_uniprotkb": "Inactive", "protein_names_refseq": "CG4536-PA; iav-PA; inactive", "tax_id": 7227, "disease": "Charcot-Marie-Tooth disease axonal type 2C (Disease Ontology:DOID:0110182); autosomal dominant nonsyndromic deafness 25 (Disease Ontology:DOID:0110555); autosomal dominant distal hereditary motor neuronopathy 8 (Disease Ontology:DOID:0111215); metatropic dysplasia (Disease Ontology:DOID:0111514); parastremmatic dwarfism (Disease Ontology:DOID:0111539); scapuloperoneal spinal muscular atrophy (Disease Ontology:DOID:0111552); spondyloepiphyseal dysplasia Maroteaux type (Disease Ontology:DOID:0111553); spondylometaphyseal dysplasia Kozlowski type (Disease Ontology:DOID:0111554); osteonecrosis (Disease Ontology:DOID:10159); pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714); hyperparathyroidism (Disease Ontology:DOID:13543); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (dme:Dmel_CG4536)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0005262 calcium channel activity;GO:0005261 monoatomic cation channel activity;GO:0140135 mechanosensitive monoatomic cation channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0034704 calcium channel complex;GO:0097731 9+0 non-motile cilium", "go_biological_process": "GO:0001964 startle response;GO:0050910 detection of mechanical stimulus involved in sensory perception of sound;GO:0006816 calcium ion transport;GO:0006812 monoatomic cation transport;GO:0007628 adult walking behavior", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W3W0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W3Y1-1", "uniprot_id": [ { "id": "CDC7_DROME", "url": "https://www.uniprot.org/uniprot/Q9W3Y1", "type": "external" } ], "mass": 78665.0, "length": 700, "protein_name": "non-specific serine/threonine protein kinase Cdc7", "gene_name": "Cdc7", "organism": "Fruit fly", "refseq_name": "Cdc7 kinase, isoform B", "refseq_ac": [ { "id": "NP_001284950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284950", "type": "external" } ], "gene_names_uniprotkb": "Cdc7; 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Phosphorylates components of the pre-replication complex, including Mcm2 and, to a lesser extent, Mcm4 (PubMed:25451925). Phosphorylates histones, including H3 and H2B (PubMed:25451925). Required for DNA replication and mitotic proliferation, including during the endoreplication and amplification stages of DNA replication in egg chamber follicle cells of the ovary (PubMed:25451925)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3KN27;X2JCT3", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0035173 histone kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031431 Dbf4-dependent protein kinase complex", "go_biological_process": "GO:0044773 mitotic DNA damage checkpoint signaling;GO:0006260 DNA replication;GO:0045740 positive regulation of DNA replication;GO:0033314 mitotic DNA replication checkpoint signaling;GO:0007113 endomitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9W3Y1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W411-1", "uniprot_id": [ { "id": "Q9W411_DROME", "url": "https://www.uniprot.org/uniprot/Q9W411", "type": "external" } ], "mass": 16362.0, "length": 149, "protein_name": "UMA domain-containing protein", "gene_name": "CG15892", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform D", "refseq_ac": [ { "id": "NP_001284939", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284939", "type": "external" } ], "gene_names_uniprotkb": "CG15892; CG15891; CG32918; Dmel\\CG15891; Dmel_CG15891", "gene_names_refseq": "CG15891; CG15892; CG32918; Dmel\\CG15891", "protein_names_uniprotkb": "UMA domain-containing protein", "protein_names_refseq": "CG15891-PD; uncharacterized protein, isoform D", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15891)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W411-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W413-1", "uniprot_id": [ { "id": "MRPP3_DROME", "url": "https://www.uniprot.org/uniprot/Q9W413", "type": "external" } ], "mass": 62156.0, "length": 544, "protein_name": "Mitochondrial ribonuclease P catalytic subunit", "gene_name": "mldr", "organism": "Fruit fly", "refseq_name": "mulder, isoform B", "refseq_ac": [ { "id": "NP_001245549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245549", "type": "external" } ], "gene_names_uniprotkb": "mldr; CG15896; MRPP3; PRORP", "gene_names_refseq": "CG15896; Dmel\\CG15896; MRPP3; PRORP; mldr", "protein_names_uniprotkb": "Mitochondrial ribonuclease P catalytic subunit; 3.1.26.5; Mitochondrial RNase P protein 3; Mitochondrial ribonuclease P protein 3; Protein mulder; Protein only RNase P catalytic subunit", "protein_names_refseq": "CG15896-PB; mldr-PB; mulder, isoform B; mulder", "tax_id": 7227, "disease": "combined oxidative phosphorylation deficiency 54 (Disease Ontology:DOID:0070427)", "pathway": " (dme:Dmel_CG15896)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;27131785;34199774;35663400", "class_list": "", "function": "Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of rswl/MRPP1, scu/MRPP2 and mldr/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:27131785). Essential for the structural and functional integrity of mitochondria (PubMed:27131785, PubMed:34199774, PubMed:35663400). Function is essential for pupal development (PubMed:27131785, PubMed:35663400)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U1E0;Q8SYK6", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004526 ribonuclease P activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0030678 mitochondrial ribonuclease P complex", "go_biological_process": "GO:0001682 tRNA 5'-leader removal;GO:0090646 mitochondrial tRNA processing;GO:0097745 mitochondrial tRNA 5'-end processing;GO:0140040 mitochondrial polycistronic RNA processing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9W413-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W437-1", "uniprot_id": [ { "id": "Q9W437_DROME", "url": "https://www.uniprot.org/uniprot/Q9W437", "type": "external" } ], "mass": 177182.0, "length": 1621, "protein_name": "Raptor, isoform B; Raptor, isoform C", "gene_name": "raptor", "organism": "Fruit fly", "refseq_name": "raptor, isoform C", "refseq_ac": [ { "id": "NP_001284924", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284924", "type": "external" } ], "gene_names_uniprotkb": "raptor; 4320; CG4320; Dmel\\CG4320; Dmel_CG4320; Raptor; dRAPTOR; dRaptor; dRap", "gene_names_refseq": "4320; CG4320; Dmel\\CG4320; Raptor; dRAPTOR; dRaptor; dRap; raptor/CG4320; raptor", "protein_names_uniprotkb": "Raptor, isoform B; Raptor, isoform C", "protein_names_refseq": "CG4320-PC; RAPTOR; TORC1; dRaptor; raptor, isoform C; raptor-PC; target of rapamycin (TOR)-associated protein", "tax_id": 7227, "disease": "nicotine dependence (Disease Ontology:DOID:0050742)", "pathway": " (dme:Dmel_CG4320); (R-DME-1632852); (R-DME-165159); (R-DME-166208); (R-DME-3371571); (R-DME-380972); (R-DME-5628897); (R-DME-8943724); (R-DME-9639288)", "pathway_count": 9, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031931 TORC1 complex", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0030307 positive regulation of cell growth;GO:0007517 muscle organ development;GO:0008286 insulin receptor signaling pathway;GO:0045793 positive regulation of cell size", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W437-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W464-1", "uniprot_id": [ { "id": "Q9W464_DROME", "url": "https://www.uniprot.org/uniprot/Q9W464", "type": "external" } ], "mass": 75310.0, "length": 674, "protein_name": "Glycosylphosphatidylinositol anchor attachment 1", "gene_name": "GAA1", "organism": "Fruit fly", "refseq_name": "glycosylphosphatidylinositol anchor attachment 1", "refseq_ac": [ { "id": "NP_572273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572273", "type": "external" } ], "gene_names_uniprotkb": "GAA1; CG3033; Dmel\\CG3033; Dmel_CG3033; GPAA1", "gene_names_refseq": "CG3033; Dmel\\CG3033; GAA1; GPAA1", "protein_names_uniprotkb": "Glycosylphosphatidylinositol anchor attachment 1", "protein_names_refseq": "CG3033-PA; GAA1-PA; glycosylphosphatidylinositol anchor attachment 1 ortholog; glycosylphosphatidylinositol anchor attachment 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3033)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system;GO:0042765 GPI-anchor transamidase complex", "go_biological_process": "GO:0016255 attachment of GPI anchor to protein;GO:0045313 rhabdomere membrane biogenesis;GO:0180046 GPI anchored protein biosynthesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W464-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W487-1", "uniprot_id": [ { "id": "Q9W487_DROME", "url": "https://www.uniprot.org/uniprot/Q9W487", "type": "external" } ], "mass": 52652.0, "length": 478, "protein_name": "DUF753 domain-containing protein", "gene_name": "Dmel\\CG15773", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": [ { "id": "NP_572251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572251", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG15773; CG15773; Dmel_CG15773", "gene_names_refseq": "CG15773; Dmel\\CG15773", "protein_names_uniprotkb": "DUF753 domain-containing protein", "protein_names_refseq": "CG15773-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W487-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W494-1", "uniprot_id": [ { "id": "Q9W494_DROME", "url": "https://www.uniprot.org/uniprot/Q9W494", "type": "external" } ], "mass": 28879.0, "length": 257, "protein_name": "Crossveinless, isoform A; Crossveinless, isoform B; Crossveinless, isoform C", "gene_name": "cv", "organism": "Fruit fly", "refseq_name": "crossveinless, isoform B", "refseq_ac": [ { "id": "NP_001284902", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284902", "type": "external" } ], "gene_names_uniprotkb": "cv; CG12410; Cv; Dmel\\CG12410; Dmel_CG12410; Tsg2; cv-1; tsg2", "gene_names_refseq": "CG12410; Cv; Dmel\\CG12410; Tsg2; cv-1; cv; tsg2", "protein_names_uniprotkb": "Crossveinless, isoform A; Crossveinless, isoform B; Crossveinless, isoform C", "protein_names_refseq": "CG12410-PB; crossveinless, isoform B; crossveinless; cv-PB; twisted gastrulation 2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12410)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036122 BMP binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0030514 negative regulation of BMP signaling pathway;GO:0030513 positive regulation of BMP signaling pathway;GO:0030510 regulation of BMP signaling pathway;GO:0110107 regulation of imaginal disc-derived wing vein specification;GO:0048636 positive regulation of muscle organ development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W494-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W499-1", "uniprot_id": [ { "id": "Q9W499_DROME", "url": "https://www.uniprot.org/uniprot/Q9W499", "type": "external" } ], "mass": 14450.0, "length": 123, "protein_name": "Large ribosomal subunit protein uL29", "gene_name": "RpL35", "organism": "Fruit fly", "refseq_name": "ribosomal protein L35, isoform C", "refseq_ac": [ { "id": "NP_001284900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284900", "type": "external" } ], "gene_names_uniprotkb": "RpL35; 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(R-DME-6798695)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.-", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.78", "type": "external" } ], "go_molecular_function": "GO:0015019 heparan-alpha-glucosaminide N-acetyltransferase activity", "go_cellular_component": "GO:0005765 lysosomal membrane", "go_biological_process": "GO:0030200 heparan sulfate proteoglycan catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W4F7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W4J2-1", "uniprot_id": [ { "id": "Q9W4J2_DROME", "url": "https://www.uniprot.org/uniprot/Q9W4J2", "type": "external" } ], "mass": 26250.0, "length": 231, "protein_name": "LITAF domain-containing protein", "gene_name": "Dmel\\CG12684", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_572173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572173", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG12684; 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CG2711; CG2714; DWG; Dmel\\CG2711; Dmel_CG2711; Dwg; EG:95B7.6; SBP; Sbp; ZW-5; ZW5; Zw-5; Zw5; l(1)3Be; l(1)zw5; ves; zw-5; zw5", "gene_names_refseq": "CG2711; CG2714; DWG; Dmel\\CG2711; Dwg; EG:95B7.6; SBP; Sbp; ZW-5; ZW5; Zw-5; Zw5; dwg; l(1)3Be; l(1)zw5; ves; zw-5; zw5", "protein_names_uniprotkb": "Deformed wings", "protein_names_refseq": "CG2711-PA; deformed wings; deformed wing; dwg-PA; scs binding protein; scs-binding protein; vestigium; zeste white 5; zeste-white 5; zeste-white5", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2711); (R-DME-9843940)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q95RB8", "ec_number_list": [], "go_molecular_function": "GO:0043035 chromatin insulator sequence binding;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W4V9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W4X2-1", "uniprot_id": [ { "id": "Q9W4X2_DROME", "url": "https://www.uniprot.org/uniprot/Q9W4X2", "type": "external" } ], "mass": 39388.0, "length": 376, "protein_name": "Helix loop helix protein 3B", "gene_name": "HLH3B", "organism": "Fruit fly", "refseq_name": "helix loop helix protein 3B", "refseq_ac": [ { "id": "NP_525055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525055", "type": "external" } ], "gene_names_uniprotkb": "HLH3B; CG2655; Dmel\\CG2655; Dmel_CG2655; DroSCL; EG:155E2.2; HLH3b; Hlh3b; bHLHa20", "gene_names_refseq": "CG2655; Dmel\\CG2655; DroSCL; EG:155E2.2; HLH3B; HLH3b; Hlh3b; bHLHa20", "protein_names_uniprotkb": "Helix loop helix protein 3B", "protein_names_refseq": "CG2655-PA; HLH3B-PA; helix loop helix protein 3B", "tax_id": 7227, "disease": "adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dme:Dmel_CG2655); (R-DME-8939236)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;40245499", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9W4X2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W4X6-1", "uniprot_id": [ { "id": "Q9W4X6_DROME", "url": "https://www.uniprot.org/uniprot/Q9W4X6", "type": "external" } ], "mass": 34181.0, "length": 304, "protein_name": "Tetraspanin", "gene_name": "Tsp3A", "organism": "Fruit fly", "refseq_name": "tetraspanin 3A, isoform B", "refseq_ac": [ { "id": "NP_001245504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245504", "type": "external" } ], "gene_names_uniprotkb": "Tsp3A; BACR7C10.6; CG10742; Dm.Tsp3A; Dmel\\CG10742; Dmel_CG10742; EG:BACR7C10.6; tsp3A", "gene_names_refseq": "BACR7C10.6; CG10742; Dm.Tsp3A; Dmel\\CG10742; EG:BACR7C10.6; Tsp3A; tsp3A", "protein_names_uniprotkb": "Tetraspanin", "protein_names_refseq": "CG10742-PB; Tsp3A-PB; tetraspanin 3A, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10742); (R-DME-6798695)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0016020 membrane;GO:0046930 pore complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0072659 protein localization to plasma membrane;GO:0051604 protein maturation;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W4X6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W533-1", "uniprot_id": [ { "id": "Q9W533_DROME", "url": "https://www.uniprot.org/uniprot/Q9W533", "type": "external" } ], "mass": 60910.0, "length": 541, "protein_name": "G-protein coupled receptors family 1 profile domain-containing protein", "gene_name": "EG:22E5.10", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform D", "refseq_ac": [ { "id": "NP_569971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569971", "type": "external" } ], "gene_names_uniprotkb": "EG:22E5.10; 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BG01596; CG13377; Dmel_CG13377; EG:BACR37P7.9", "gene_names_refseq": "BG01596; CG13377; Dmel\\CG13377; EG:BACR37P7.9", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "BG01596; CG13377-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13377)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9U1L9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W5H1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W5X5-1", "uniprot_id": [ { "id": "Q9W5X5_DROME", "url": "https://www.uniprot.org/uniprot/Q9W5X5", "type": "external" } ], "mass": 30056.0, "length": 260, "protein_name": "Forkhead domain 19B", "gene_name": "fd19B", "organism": "Fruit fly", "refseq_name": "forkhead domain 19B", "refseq_ac": [ { "id": "NP_608369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608369", "type": "external" } ], "gene_names_uniprotkb": "fd19B; CG9571; Dmcg9571; Dmel\\CG9571; Dmel_CG9571; FoxG", "gene_names_refseq": "CG9571; Dmcg9571; Dmel\\CG9571; FoxG; fd19B", "protein_names_uniprotkb": "Forkhead domain 19B", "protein_names_refseq": "CG9571-PA; fd19B-PA; forkhead domain 19B", "tax_id": 7227, "disease": "Goldenhar syndrome (Disease Ontology:DOID:2907)", "pathway": " (dme:Dmel_CG9571)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W5X5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9XTP7-1", "uniprot_id": [ { "id": "Q9XTP7_DROME", "url": "https://www.uniprot.org/uniprot/Q9XTP7", "type": "external" } ], "mass": 77719.0, "length": 719, "protein_name": "Jumeau", "gene_name": "jumu", "organism": "Fruit fly", "refseq_name": "jumeau", "refseq_ac": [ { "id": "NP_524302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524302", "type": "external" } ], "gene_names_uniprotkb": "jumu; 5295; CG4029; Dmel\\CG4029; Dmel_CG4029; Dmjumu; Dom; Dwhn; E(var)631; FoxN14; Jumeau; Jumu; Scim31; Whn; jumeaux; l(3)06142; l(3)06439", "gene_names_refseq": "5295; CG4029; Dmel\\CG4029; Dmjumu; Dom; Dwhn; E(var)631; FoxN14; Jumeau; Jumu; Scim31; Whn; jumeaux; jumu/Dom; jumu; l(3)06142; l(3)06439", "protein_names_uniprotkb": "Jumeau", "protein_names_refseq": "CG4029-PA; domina; jumeaux; jumeau; jumu-PA; winged-helix nude-like", "tax_id": 7227, "disease": "T-cell immunodeficiency, congenital alopecia, and nail dystrophy (Disease Ontology:DOID:0060769); DiGeorge syndrome (Disease Ontology:DOID:11198); Nezelof syndrome (Disease Ontology:DOID:2012); nail disease (Disease Ontology:DOID:4123); primary immunodeficiency disease (Disease Ontology:DOID:612); alopecia (Disease Ontology:DOID:987)", "pathway": " (dme:Dmel_CG4029)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000785 chromatin;GO:0000791 euchromatin;GO:0005700 polytene chromosome", "go_biological_process": "GO:0007000 nucleolus organization;GO:0048749 compound eye development;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0009611 response to wounding", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9XTP7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9XYZ4-1", "uniprot_id": [ { "id": "Q9XYZ4_DROME", "url": "https://www.uniprot.org/uniprot/Q9XYZ4", "type": "external" } ], "mass": 69285.0, "length": 620, "protein_name": "Double-strand break repair protein", "gene_name": "mre11", "organism": "Fruit fly", "refseq_name": "meiotic recombination 11", "refseq_ac": [ { "id": "NP_523547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523547", "type": "external" } ], "gene_names_uniprotkb": "mre11; 16928; CG16928; Dmel\\CG16928; Dmel_CG16928; MRE11; Mre11; dMre11", "gene_names_refseq": "16928; CG16928; Dmel\\CG16928; MRE11; Mre11; dMre11; mre11", "protein_names_uniprotkb": "Double-strand break repair protein", "protein_names_refseq": "CG16928-PA; meiotic recombination 11; mre11-PA", "tax_id": 7227, "disease": "ataxia-telangiectasia-like disorder 1 (Disease Ontology:DOID:0081384); intestinal cancer (Disease Ontology:DOID:10155); Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); rectum cancer (Disease Ontology:DOID:1993); colon cancer (Disease Ontology:DOID:219); ovarian cancer (Disease Ontology:DOID:2394); malignant astrocytoma (Disease Ontology:DOID:3069); breast carcinoma (Disease Ontology:DOID:3459); liver cancer (Disease Ontology:DOID:3571); Lynch syndrome (Disease Ontology:DOID:3883); skin cancer (Disease Ontology:DOID:4159); stomach carcinoma (Disease Ontology:DOID:5517)", "pathway": " (dme:Dmel_CG16928); (R-DME-1834949); (R-DME-2559586); (R-DME-5685939); (R-DME-5693548); (R-DME-5693565); (R-DME-5693607)", "pathway_count": 7, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0030145 manganese ion binding;GO:0000014 single-stranded DNA endodeoxyribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0035861 site of double-strand break;GO:0030870 Mre11 complex", "go_biological_process": "GO:0000723 telomere maintenance;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0000724 double-strand break repair via homologous recombination;GO:0031573 mitotic intra-S DNA damage checkpoint signaling;GO:0007095 mitotic G2 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9XYZ4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9XZ11-1", "uniprot_id": [ { "id": "Q9XZ11_DROME", "url": "https://www.uniprot.org/uniprot/Q9XZ11", "type": "external" } ], "mass": 109358.0, "length": 969, "protein_name": "Smr domain-containing protein", "gene_name": "Dmel\\CG7139", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_649378", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649378", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG7139; BcDNA:LD21293; CG7139; Dmel_CG7139; anon-WO0118547.415; mdcds_30855", "gene_names_refseq": "BcDNA:LD21293; CG7139; Dmel\\CG7139; anon-WO0118547.415; mdcds_30855", "protein_names_uniprotkb": "Smr domain-containing protein", "protein_names_refseq": "CG7139-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7139)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004519 endonuclease activity;GO:0004520 DNA endonuclease activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9XZ11-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Y110-1", "uniprot_id": [ { "id": "Q9Y110_DROME", "url": "https://www.uniprot.org/uniprot/Q9Y110", "type": "external" } ], "mass": 73355.0, "length": 675, "protein_name": "MANSC domain-containing protein", "gene_name": "GH10711", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_609451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609451", "type": "external" } ], "gene_names_uniprotkb": "GH10711; BcDNA:GH10711; CG6495; Dmel\\CG6495; Dmel_CG6495", "gene_names_refseq": "BcDNA:GH10711; CG6495; Dmel\\CG6495; GH10711", "protein_names_uniprotkb": "MANSC domain-containing protein", "protein_names_refseq": "CG6495-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6495)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Y110-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Y119-1", "uniprot_id": [ { "id": "Q9Y119_DROME", "url": "https://www.uniprot.org/uniprot/Q9Y119", "type": "external" } ], "mass": 91135.0, "length": 809, "protein_name": "2.4.1.15; 3.1.3.12; Trehalose-6-phosphate synthase 1", "gene_name": "Tps1", "organism": "Fruit fly", "refseq_name": "Trehalose-6-phosphate synthase 1", "refseq_ac": [ { "id": "NP_608827", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608827", "type": "external" } ], "gene_names_uniprotkb": "Tps1; 19920676; BcDNA:GH08860; CG4104 PA; CG4104; DmTPS1; Dmel\\CG4104; Dmel_CG4104; TPS; TreS; dTps1; dtps1; jf5; l(2)24Ea; l(2)jf4; l(2)jf5; l(2)k08903; tps1; tps", "gene_names_refseq": "19920676; BcDNA:GH08860; CG4104 PA; CG4104; DmTPS1; Dmel\\CG4104; TPS; Tps1; TreS; dTps1; dtps1; jf5; l(2)24Ea; l(2)jf4; l(2)jf5; l(2)k08903; tps1; tps", "protein_names_uniprotkb": "2.4.1.15; 3.1.3.12; Trehalose-6-phosphate synthase 1", "protein_names_refseq": "CG4104-PA; Tps1-PA; Trehalos-6-phosphate synthase; Trehalose-6-phosphate phosphatase; Trehalose-6-phosphate synthase 1; lethal(2)24Ea; trehalose synthase; trehalose-6-phosphate synthase; trehalose-phosphate synthase", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4104)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004805 trehalose-phosphatase activity;GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0005992 trehalose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Y119-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Y143-1", "uniprot_id": [ { "id": "Q9Y143_DROME", "url": "https://www.uniprot.org/uniprot/Q9Y143", "type": "external" } ], "mass": 29605.0, "length": 262, "protein_name": "Juvenile hormone binding protein 14", "gene_name": "Jhbp14", "organism": "Fruit fly", "refseq_name": "juvenile hormone binding protein 14", "refseq_ac": [ { "id": "NP_609625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609625", "type": "external" } ], "gene_names_uniprotkb": "Jhbp14; BcDNA:GH05536; CG5867; CT18390; Dmel\\CG5867; Dmel_CG5867; JHBP14", "gene_names_refseq": "BcDNA:GH05536; CG5867; CT18390; Dmel\\CG5867; JHBP14; Jhbp14", "protein_names_uniprotkb": "Juvenile hormone binding protein 14", "protein_names_refseq": "CG5867-PA; Jhbp14-PA; juvenile hormone binding protein 14", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5867)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Y143-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "X2JEE5-1", "uniprot_id": [ { "id": "X2JEE5_DROME", "url": "https://www.uniprot.org/uniprot/X2JEE5", "type": "external" } ], "mass": 24168.0, "length": 247, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG2157", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001285093", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285093", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG2157; CG2157; Dmel_CG2157", "gene_names_refseq": "CG2157; Dmel\\CG2157", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG2157-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2157)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "X2JEE5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49455-1", "uniprot_id": [ { "id": "TPM4_DROME", "url": "https://www.uniprot.org/uniprot/P49455", "type": "external" } ], "mass": 54585.0, "length": 518, "protein_name": "Tropomyosin-1, isoforms 33/34", "gene_name": "Tm1", "organism": "Fruit fly", "refseq_name": "tropomyosin 1, isoform F", "refseq_ac": [ { "id": "NP_732005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_732005", "type": "external" } ], "gene_names_uniprotkb": "Tm1; 10; 2299; BcDNA:GH09289; BcDNA:LD37158; BcDNA:SD21996; CG4898; Dm Tm1; Dm TmH33; Dm TmH34; DmTm1; Dmel\\CG4898; Dmel_CG4898; PmI; TM1; TMII; TM; TmH-33; TmH-34; TmH33; TmH34; TmH; TmII; Tmr33; Tmr34; Tm; TnH-33; TnH-34; TnH; cTM; cTmII; cTm; chr3R:11122272..11122408; l(3)02299; l(3)S130510; l(3)s2958; mTmII; region 3; tm1; tmII; tropomyosin", "gene_names_refseq": "1305/10; 2299; BcDNA:GH09289; BcDNA:LD37158; BcDNA:SD21996; CG4898; Dm Tm1; Dm TmH33; Dm TmH34; DmTm1; Dmel\\CG4898; PmI; TM1; TMII; TM; Tm1; TmH-33; TmH-34; TmH33; TmH34; TmH; TmII; Tmr33; Tmr34; Tm; TnH-33; TnH-34; TnH; cTM; cTmII; cTm; chr3R:11122272..11122408; l(3)02299; l(3)S130510; l(3)s2958; mTmII; region 3; tm1; tmII; tropomyosin", "protein_names_uniprotkb": "Tropomyosin-1, isoforms 33/34; Tropomyosin II", "protein_names_refseq": "CG4898-PF; Tm1-PF; Tropomyosin-1; Tropomyosin1; cytoplasmic tropomyosin; cytoskeletal tropomyosin; tropomyosin 1, isoform F; tropomyosin II; tropomyosin I; tropomyosinII; tropomysin II; troponin H; troponin-H isoform 34", "tax_id": 7227, "disease": "familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); hypertrophic cardiomyopathy 3 (Disease Ontology:DOID:0110309); dilated cardiomyopathy 1Y (Disease Ontology:DOID:0110457); congenital myopathy 23 (Disease Ontology:DOID:0110932); distal arthrogryposis type 1A (Disease Ontology:DOID:0111597); blood platelet disease (Disease Ontology:DOID:2218)", "pathway": " (dme:Dmel_CG4898); (R-DME-445355); (R-DME-9013424)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;26251439;2851721;3097506;3693358;3803921", "class_list": "", "function": "Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P49456;Q24425;Q24426;Q7KSH9;Q7KSI0", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0019901 protein kinase binding;GO:0051015 actin filament binding;GO:0019894 kinesin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0030017 sarcomere;GO:0070865 investment cone;GO:0005884 actin filament;GO:0043186 P granule", "go_biological_process": "GO:0006936 muscle contraction;GO:0048813 dendrite morphogenesis;GO:0048477 oogenesis;GO:0055093 response to hyperoxia;GO:0010591 regulation of lamellipodium assembly", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P49455-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "X2JEM2-1", "uniprot_id": [ { "id": "X2JEM2_DROME", "url": "https://www.uniprot.org/uniprot/X2JEM2", "type": "external" } ], "mass": 256011.0, "length": 2326, "protein_name": "Secretory 16, isoform I", "gene_name": "Sec16", "organism": "Fruit fly", "refseq_name": "secretory 16, isoform I", "refseq_ac": [ { "id": "NP_001285158", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285158", "type": "external" } ], "gene_names_uniprotkb": "Sec16; BcDNA:RE70141; CG18079; CG2551; CG32654; Dmel\\CG32654; Dmel_CG32654; dSec16; dsec16; sec16; sec26", "gene_names_refseq": "BcDNA:RE70141; CG18079; CG2551; CG32654; Dmel\\CG32654; Sec16; dSec16; dsec16; sec16; sec26", "protein_names_uniprotkb": "Secretory 16, isoform I", "protein_names_refseq": "CG32654-PI; Sec16 ortholog; Sec16-PI; secretory 16, isoform I", "tax_id": 7227, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG32654)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0012507 ER to Golgi transport vesicle membrane;GO:0070971 endoplasmic reticulum exit site;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0034198 cellular response to amino acid starvation;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0048208 COPII vesicle coating;GO:1990928 response to amino acid starvation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "X2JEM2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "X2JEB8-1", "uniprot_id": [ { "id": "X2JEB8_DROME", "url": "https://www.uniprot.org/uniprot/X2JEB8", "type": "external" } ], "mass": 26832.0, "length": 235, "protein_name": "Dual specificity protein phosphatase", "gene_name": "Dmel\\CG7378; MKP-like", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": [ { "id": "NP_001285421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285421", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG7378; MKP-like; BcDNA:RH25447; CG7378; Dmel\\CG7378; Dmel_CG7378; MKP-like", "gene_names_refseq": "BcDNA:RH25447; CG7378; Dmel\\CG7378; MKP-like", "protein_names_uniprotkb": "Dual specificity protein phosphatase; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "CG7378-PC; MKP-like; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "lung adenocarcinoma (Disease Ontology:DOID:3910)", "pathway": " (dme:Dmel_CG7378)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity;GO:0033549 MAP kinase phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043409 negative regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "X2JEB8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26016-1", "uniprot_id": [ { "id": "FUR11_DROME", "url": "https://www.uniprot.org/uniprot/P26016", "type": "external" } ], "mass": 138627.0, "length": 1269, "protein_name": "Furin-like protease 1, isoforms 1/1-X/2", "gene_name": "Fur1", "organism": "Fruit fly", "refseq_name": "furin 1, isoform B", "refseq_ac": [ { "id": "NP_524885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524885", "type": "external" } ], "gene_names_uniprotkb": "Fur1; CG10772; Dfur1; Dfurin1; Dmel\\CG10772; Dmel_CG10772; Furin; Furl; Klip1; dFur1; dFurin 1; dKLIP-1; fur-1; fur1; fur[1]; furin; l(3)rL205", "gene_names_refseq": "CG10772; Dfur1; Dfurin1; Dmel\\CG10772; Fur1; Furin; Furl; Klip1; dFur1; dFurin 1; dKLIP-1; fur-1; fur1; fur[1]; furin; l(3)rL205", "protein_names_uniprotkb": "Furin-like protease 1, isoforms 1/1-X/2; 3.4.21.75; Furin-1; Kex2-like endoprotease 1; dKLIP-1", "protein_names_refseq": "CG10772-PB; Dfurin1; Fur1-PB; Furin-like protease; Furin1; furin 1, isoform B; furin", "tax_id": 7227, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); arteriosclerosis (Disease Ontology:DOID:2349); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dme:Dmel_CG10772); (R-DME-1592389); (R-DME-186797); (R-DME-2173789); (R-DME-2173796); (R-DME-8963889)", "pathway_count": 6, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;1545235;16110336;17569856;17569867;1915835;25589440;26109356;26109357;8491178", "class_list": "", "function": "Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 13, "predicted_n_glycosites": 13, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "A4V3E2;Q05817;Q27436", "ec_number_list": [ { "id": "3.4.21.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0097688 glutamate receptor clustering;GO:0006508 proteolysis;GO:0001941 postsynaptic membrane organization;GO:0097090 presynaptic membrane organization;GO:0008039 synaptic target recognition", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P26016-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "X2JCR2-1", "uniprot_id": [ { "id": "X2JCR2_DROME", "url": "https://www.uniprot.org/uniprot/X2JCR2", "type": "external" } ], "mass": 89077.0, "length": 828, "protein_name": "Uncharacterized protein", "gene_name": "CG18632; CG3628", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform I", "refseq_ac": [ { "id": "NP_001287006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287006", "type": "external" } ], "gene_names_uniprotkb": "CG18632; CG3628; CG14180; CG18632; CG32043; CG3628; CG44838; Dmel\\CG44838; Dmel_CG44838; anon-WO0118547.368; anon-WO0118547.427", "gene_names_refseq": "CG14180; CG18632; CG32043; CG3628; CG44838; Dmel\\CG44838; anon-WO0118547.368; anon-WO0118547.427", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG44838-PI; rugose; uncharacterized protein, isoform I", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG44838); (R-DME-6798695)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "X2JCR2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Y165-1", "uniprot_id": [ { "id": "Q9Y165_DROME", "url": "https://www.uniprot.org/uniprot/Q9Y165", "type": "external" } ], "mass": 55878.0, "length": 491, "protein_name": "E2 ubiquitin-conjugating enzyme", "gene_name": "morgue", "organism": "Fruit fly", "refseq_name": "modifier of rpr and grim, ubiquitously expressed", "refseq_ac": [ { "id": "NP_608833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608833", "type": "external" } ], "gene_names_uniprotkb": "morgue; BcDNA:GH02435; CG15437; Dmel\\CG15437; Dmel_CG15437; FBXO18; Morgue", "gene_names_refseq": "BcDNA:GH02435; CG15437; Dmel\\CG15437; FBXO18; Morgue; morgue", "protein_names_uniprotkb": "E2 ubiquitin-conjugating enzyme; 2.3.2.23", "protein_names_refseq": "CG15437-PA; modifier of rpr and grim, ubiquitously expressed; morgue-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15437)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0005524 ATP binding;GO:0016740 transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:1901694 positive regulation of compound eye retinal cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Y165-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Y170-1", "uniprot_id": [ { "id": "Q9Y170_DROME", "url": "https://www.uniprot.org/uniprot/Q9Y170", "type": "external" } ], "mass": 16887.0, "length": 148, "protein_name": "Sex-regulated protein janus-B", "gene_name": "ocn", "organism": "Fruit fly", "refseq_name": "ocnus", "refseq_ac": [ { "id": "NP_524578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524578", "type": "external" } ], "gene_names_uniprotkb": "ocn; BcDNA:GH02250; CG7929; Dmel\\CG7929; Dmel_CG7929; FBgn0041102; Ocn; bs29e10.y1", "gene_names_refseq": "BcDNA:GH02250; CG7929; Dmel\\CG7929; FBgn0041102; Ocn; bs29e10.y1; ocn", "protein_names_uniprotkb": "Sex-regulated protein janus-B", "protein_names_refseq": "CG7929-PA; ocn-PA; ocnus", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7929)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "JanA and janB regulate somatic sex differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0101006 protein histidine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0030154 cell differentiation;GO:0007548 sex differentiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9Y170-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9Y1A7-1", "uniprot_id": [ { "id": "Q9Y1A7_DROME", "url": "https://www.uniprot.org/uniprot/Q9Y1A7", "type": "external" } ], "mass": 54350.0, "length": 499, "protein_name": "Minidiscs, isoform A; Minidiscs, isoform C; Minidiscs, isoform D", "gene_name": "mnd", "organism": "Fruit fly", "refseq_name": "minidiscs, isoform A", "refseq_ac": [ { "id": "NP_524074", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524074", "type": "external" } ], "gene_names_uniprotkb": "mnd; CG3297; Dmel\\CG3297; Dmel_CG3297; MND; Mnd; SG29; l(3)B5; l(3)SG29; l(3)ds-5; l(3)ds5; l(3)o52; md", "gene_names_refseq": "CG3297; Dmel\\CG3297; MND; Mnd; SG29; l(3)B5; l(3)SG29; l(3)ds-5; l(3)ds5; l(3)o52; md; mnd", "protein_names_uniprotkb": "Minidiscs, isoform A; Minidiscs, isoform C; Minidiscs, isoform D", "protein_names_refseq": "CG3297-PA; minidiscs, isoform A; minidiscs; minidisks; mnd-PA", "tax_id": 7227, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); large cell neuroendocrine carcinoma (Disease Ontology:DOID:0050872); autism spectrum disorder (Disease Ontology:DOID:0060041); adenoid cystic carcinoma (Disease Ontology:DOID:0080202); lung pleomorphic carcinoma (Disease Ontology:DOID:0080899); stomach cancer (Disease Ontology:DOID:10534); esophageal carcinoma (Disease Ontology:DOID:1107); esophagitis (Disease Ontology:DOID:11963); rectum adenocarcinoma (Disease Ontology:DOID:1996); colon cancer (Disease Ontology:DOID:219); transitional cell carcinoma (Disease Ontology:DOID:2671); glioblastoma (Disease Ontology:DOID:3068); malignant astrocytoma (Disease Ontology:DOID:3069); high grade glioma (Disease Ontology:DOID:3070); extrahepatic bile duct adenocarcinoma (Disease Ontology:DOID:3495); gastric adenocarcinoma (Disease Ontology:DOID:3717); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); bile duct adenocarcinoma (Disease Ontology:DOID:4896); bile duct carcinoma (Disease Ontology:DOID:4897); cholangiocarcinoma (Disease Ontology:DOID:4947); hepatocellular carcinoma (Disease Ontology:DOID:684); malignant pleural mesothelioma (Disease Ontology:DOID:7474); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG3297); (R-DME-209360); (R-DME-209406); (R-DME-209461); (R-DME-210991); (R-DME-216167); (R-DME-352230); (R-DME-432395); (R-DME-432524); (R-DME-432626); (R-DME-538864); (R-DME-71240)", "pathway_count": 12, "publication_count": 43, "publication_id_list": "10102270;10417378;10458606;10481010;10731132;11585911;12231619;12432393;12442174;12537568;12537572;12537573;12537574;12973300;15178801;15258584;15331761;16110336;16139204;16299518;16326393;16386907;16543224;16603629;16651542;16740475;16794082;17102630;17569856;17569867;17925225;18519643;18593878;19185492;25589440;26109356;26109357;7705656;8948598;9025065;9215627;9553105;9990853", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7KUL6", "ec_number_list": [], "go_molecular_function": "GO:0015179 L-amino acid transmembrane transporter activity;GO:0015171 amino acid transmembrane transporter activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:1903801 L-leucine import across plasma membrane;GO:0006865 amino acid transport;GO:0003333 amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 4.4, "record_id": "Q9Y1A7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "R9PY48-1", "uniprot_id": [ { "id": "R9PY48_DROME", "url": "https://www.uniprot.org/uniprot/R9PY48", "type": "external" } ], "mass": 21638.0, "length": 193, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG32507", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_728363", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_728363", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG32507; 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CG45084; Dmel_CG45084", "gene_names_refseq": "CG45084; Dmel\\CG45084; Dromel_CG4824_FBtr0080804_bicc_uORF", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG45084-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG45084)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "X2JAK7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "X2JLC4-1", "uniprot_id": [ { "id": "X2JLC4_DROME", "url": "https://www.uniprot.org/uniprot/X2JLC4", "type": "external" } ], "mass": 10099.0, "length": 90, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG45486", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_001285467", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285467", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG45486; 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CG30331; CG32834; Dmel\\CG32834; Dmel_CG32834; SPH196b; SPH196", "gene_names_refseq": "CG30331; CG32834; CG9898; Dmel\\CG32834; SPH196b; SPH196", "protein_names_uniprotkb": "Peptidase S1 domain-containing protein", "protein_names_refseq": "CG32834-PB; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32834)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A0B4JCV5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4JCY2-1", "uniprot_id": [ { "id": "A0A0B4JCY2_DROME", "url": "https://www.uniprot.org/uniprot/A0A0B4JCY2", "type": "external" } ], "mass": 24595.0, "length": 211, "protein_name": "Uncharacterized protein", "gene_name": "CG31392", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_001189223", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189223", "type": "external" } ], "gene_names_uniprotkb": "CG31392; CG12258; CG42727; Dmel\\CG42727; Dmel_CG42727", "gene_names_refseq": "CG12258; CG31392; CG42727; Dmel\\CG42727", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG42727-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42727)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A0B4JCY2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1Z7T0-1", "uniprot_id": [ { "id": "PKN_DROME", "url": "https://www.uniprot.org/uniprot/A1Z7T0", "type": "external" } ], "mass": 131791.0, "length": 1190, "protein_name": "Serine/threonine-protein kinase N", "gene_name": "Pkn", "organism": "Fruit fly", "refseq_name": "protein kinase N, isoform M", "refseq_ac": [ { "id": "NP_001246220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246220", "type": "external" } ], "gene_names_uniprotkb": "Pkn; 3-2; CG2049; CG2055; CG8; CT6637; CT6660; DPKN; Dmel\\CG2049; Dmel_CG2049; Dpkn; PKC-related; PKN; PRK2; Pk45C; Pk?3; dPKN; l(2)06736; l(2)45Ca; pkn; v(2)rG232", "gene_names_refseq": "3-2; CG2049; CG2055; CG8; CT6637; CT6660; DPKN; Dmel\\CG2049; Dpkn; PKC-related; PKN; PRK2; Pk45C; Pk?3; Pkn; dPKN; l(2)06736; l(2)45Ca; pkn; v(2)rG232", "protein_names_uniprotkb": "Serine/threonine-protein kinase N; 2.7.11.13; Protein kinase related to PKN", "protein_names_refseq": "CG2049-PM; Pkn-PM; complementation group 8; protein kinase N, isoform M; protein kinase c related; protein kinase related to protein kinase N; protein kinase-like 45C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2049); (R-DME-5625740); (R-DME-5625886); (R-DME-8980692); (R-DME-9013149); (R-DME-9856530)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10323867;10731132;12537568;12537572;12537573;12537574;16110336;17507675;17569856;17569867;25589440;26109356;26109357;9125115", "class_list": "", "function": "Pkc-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. May play a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion and transcription activation signaling processes (By similarity). Plays a role in regulating Rho-mediated dorsal closure during embryogenesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C7LA81", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.14.99.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0031267 small GTPase binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity", "go_cellular_component": "GO:0045179 apical cortex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007155 cell adhesion;GO:0035556 intracellular signal transduction;GO:0030036 actin cytoskeleton organization;GO:0046777 protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "A1Z7T0-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0KIC3-1", "uniprot_id": [ { "id": "Y3427_DROME", "url": "https://www.uniprot.org/uniprot/Q0KIC3", "type": "external" } ], "mass": 149300.0, "length": 1372, "protein_name": "Uncharacterized protein CG43427", "gene_name": "smash", "organism": "Fruit fly", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "smash; CG1054; CG1055; CG14653; CG18253; CG31531; CG31534; CG43427; Dmel\\CG43427; Dmel_CG43427; Smash; anon-WO0140519.95", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein CG43427", "protein_names_refseq": "", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG43427)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17018572;17569856;17569867;25589440;26109356;26109357;40245499", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B5RIU0;Q8SX99", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005911 cell-cell junction;GO:0005915 zonula adherens", "go_biological_process": "GO:0150105 protein localization to cell-cell junction;GO:0030036 actin cytoskeleton organization;GO:0016331 morphogenesis of embryonic epithelium", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q0KIC3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25153-1", "uniprot_id": [ { "id": "UBCD6_DROME", "url": "https://www.uniprot.org/uniprot/P25153", "type": "external" } ], "mass": 17152.0, "length": 151, "protein_name": "Ubiquitin-conjugating enzyme E2-17 kDa", "gene_name": "Ubc6", "organism": "Fruit fly", "refseq_name": "ubiquitin conjugating enzyme 6, isoform C", "refseq_ac": [ { "id": "NP_001246916", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246916", "type": "external" } ], "gene_names_uniprotkb": "Ubc6; BcDNA:RE56673; CG2013; Dhr6; Dmel\\CG2013; Dmel_CG2013; RAD6; Rad6a; Rad6; UBC6; UbcD6; Ubcd6; dRAD6; dRad6", "gene_names_refseq": "BcDNA:RE56673; CG2013; Dhr6; Dmel\\CG2013; RAD6; Rad6a; Rad6; UBC6; Ubc6; UbcD6; Ubcd6; dRAD6; dRad6", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2-17 kDa; 2.3.2.23; E2 ubiquitin-conjugating enzyme 6; RAD6 homolog; Ubiquitin carrier protein; Ubiquitin-protein ligase; dRad6", "protein_names_refseq": "CG2013-PC; Ubc6-PC; ubiquitin conjugating enzyme 6, isoform C; ubiquitin conjugating enzyme", "tax_id": 7227, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); syndromic X-linked intellectual disability Nascimento type (Disease Ontology:DOID:0060820); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (dme:Dmel_CG2013); (R-DME-8866652); (R-DME-8866654); (R-DME-983168)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;1902572;23685073;25589440;26109356;26109357;27552662", "class_list": "", "function": "E2 ubiquitin-conjugating enzyme that accepts ubiquitin from the ubiquitin-activating enzyme E1 and transfers it to a E3 ubiquitin-protein ligase (By similarity). Required for postreplication repair of UV-damaged DNA (PubMed:1902572). Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the putative E3 ligases poe, Kcmf1 and Ufd4 to mediate the ubiquitination and proteasomal degradation of rl/MAPK (PubMed:27552662). Required for in mitophagy (PubMed:23685073)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VN70", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0004842 ubiquitin-protein transferase activity;GO:0002039 p53 binding;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0033503 HULC complex", "go_biological_process": "GO:1901526 positive regulation of mitophagy;GO:0006281 DNA repair;GO:0007507 heart development;GO:0043066 negative regulation of apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P25153-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8JQ65-1", "uniprot_id": [ { "id": "DGKH_DROME", "url": "https://www.uniprot.org/uniprot/A8JQ65", "type": "external" } ], "mass": 211659.0, "length": 1895, "protein_name": "Diacylglycerol kinase eta", "gene_name": "CG2667; CG31187", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": [ { "id": "NP_001097704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097704", "type": "external" } ], "gene_names_uniprotkb": "CG2667; CG31187; CG14462; CG2667; CG31187; CG34384; CG9851; DGKd; DgkD; Dmel\\CG34384; Dmel_CG34384; dgkd; dgk", "gene_names_refseq": "CG14462; CG2667; CG31187; CG34384; CG9851; DGKd; DgkD; Dmel\\CG34384; dgkd; dgk", "protein_names_uniprotkb": "Diacylglycerol kinase eta; 2.7.1.107; DAG kinase eta", "protein_names_refseq": "CG34384-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "Lennox-Gastaut syndrome (Disease Ontology:DOID:0050561)", "pathway": " (dme:Dmel_CG34384); (R-DME-114508)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q86NT9", "ec_number_list": [ { "id": "2.7.1.107", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.107", "type": "external" }, { "id": "2.7.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.94", "type": "external" }, { "id": "2.7.1.138", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.138", "type": "external" } ], "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0046486 glycerolipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A8JQ65-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4K692-1", "uniprot_id": [ { "id": "NEP2_DROME", "url": "https://www.uniprot.org/uniprot/A0A0B4K692", "type": "external" } ], "mass": 88125.0, "length": 774, "protein_name": "Neprilysin-2", "gene_name": "Nep2", "organism": "Fruit fly", "refseq_name": "neprilysin 2, isoform B", "refseq_ac": [ { "id": "NP_001246914", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246914", "type": "external" } ], "gene_names_uniprotkb": "Nep2; CG9761", "gene_names_refseq": "BcDNA:GH07643; CG9761; DmNEP2; Dmel\\CG9761; NEP2; Nep2; dNEP2; nep2", "protein_names_uniprotkb": "Neprilysin-2; 3.4.24.11", "protein_names_refseq": "CG9761-PB; Nep2-PB; neprilysin 2, isoform B; neprilysin 2; neprilysin-2", "tax_id": 7227, "disease": "Charcot-Marie-Tooth disease axonal type 2T (Disease Ontology:DOID:0110160); cerebellar ataxia type 43 (Disease Ontology:DOID:0111745); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); membranous glomerulonephritis (Disease Ontology:DOID:10976); diarrhea (Disease Ontology:DOID:13250); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); periodontitis (Disease Ontology:DOID:824); cerebral amyloid angiopathy (Disease Ontology:DOID:9246)", "pathway": " (dme:Dmel_CG9761)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;10731138;12537572;15554877;17157960;24395329;27629706;40245499", "class_list": "", "function": "Metalloendoprotease which cleaves peptides such as tachykinin peptide TK-2 at the amino side of hydrophobic residues (PubMed:15554877, PubMed:17157960). Functions in female fertility, embryogenesis and memory formation (PubMed:24395329, PubMed:27629706). Required in females for normal patterns of egg laying, probably due to its function in sperm retention and preventing sperm displacement by rival ejaculates (PubMed:24395329). Also required for normal patterns of hatching due to its important role in early embryonic development (PubMed:24395329). Required in the dorsal paired medial neurons for the proper formation of middle-term memory (PubMed:27629706). Also required in the mushroom body neurons where it functions redundantly with neprilysins Nep3 and Nep4 in normal long-term memory formation (PubMed:27629706)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 10, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "D3DMK4;Q9XZ01", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0046692 sperm competition", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A0A0B4K692-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4K6G3-1", "uniprot_id": [ { "id": "A0A0B4K6G3_DROME", "url": "https://www.uniprot.org/uniprot/A0A0B4K6G3", "type": "external" } ], "mass": 222227.0, "length": 2018, "protein_name": "Protein partner of snf, isoform B", "gene_name": "pps", "organism": "Fruit fly", "refseq_name": "protein partner of snf, isoform B", "refseq_ac": [ { "id": "NP_001247075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247075", "type": "external" } ], "gene_names_uniprotkb": "pps; CG6525; Dmel\\CG6525; Dmel_CG6525; FBgn0082831; PPS; SPP; Spp; spp", "gene_names_refseq": "CG6525; Dmel\\CG6525; FBgn0082831; PPS; SPP; Spp; pps; spp", "protein_names_uniprotkb": "Protein partner of snf, isoform B", "protein_names_refseq": "CG6525-PB; SNFs protein partner; pps-PB; protein partner of sans fille; protein partner of sans-fille; protein partner of snf, isoform B", "tax_id": 7227, "disease": "myelodysplastic/myeloproliferative neoplasm (Disease Ontology:DOID:4972)", "pathway": " (dme:Dmel_CG6525)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;28919441;33925313", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0030532 small nuclear ribonucleoprotein complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "A0A0B4K6G3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4K6N4-1", "uniprot_id": [ { "id": "A0A0B4K6N4_DROME", "url": "https://www.uniprot.org/uniprot/A0A0B4K6N4", "type": "external" } ], "mass": 63447.0, "length": 567, "protein_name": "Tropomodulin, isoform N", "gene_name": "tmod", "organism": "Fruit fly", "refseq_name": "tropomodulin, isoform N", "refseq_ac": [ { "id": "NP_001247372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247372", "type": "external" } ], "gene_names_uniprotkb": "tmod; 10; CG11493; CG1539; CG15540; CT3919; CT41421; Dmel\\CG1539; Dmel_CG1539; E42; Tmod; l(3)00848; l(3)S130910; spdo", "gene_names_refseq": "1309/10; CG11493; CG1539; CG15540; CT3919; CT41421; Dmel\\CG1539; E42; Tmod; l(3)00848; l(3)S130910; spdo; tmod", "protein_names_uniprotkb": "Tropomodulin, isoform N", "protein_names_refseq": "CG1539-PN; sanpodo; tmod-PN; tropmodulin; tropomodulin, isoform N; tropomodulin", "tax_id": 7227, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (dme:Dmel_CG1539); (R-DME-445355); (R-DME-9013418)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005523 tropomyosin binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005938 cell cortex;GO:0031430 M band;GO:0030016 myofibril;GO:0045169 fusome", "go_biological_process": "GO:0007015 actin filament organization;GO:0051694 pointed-end actin filament capping;GO:0030239 myofibril assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A0B4K6N4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48456-1", "uniprot_id": [ { "id": "PP2B1_DROME", "url": "https://www.uniprot.org/uniprot/P48456", "type": "external" } ], "mass": 69133.0, "length": 622, "protein_name": "Serine/threonine-protein phosphatase 2B catalytic subunit 1", "gene_name": "CanA1", "organism": "Fruit fly", "refseq_name": "calcineurin A1, isoform D", "refseq_ac": [ { "id": "NP_001247378", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247378", "type": "external" } ], "gene_names_uniprotkb": "CanA1; CG1455; CNA1; CaNA1; CaN; Cana1; Can; CnA; CnnA21EF; D14; DmCanA1-100B; Dmel\\CG1455; Dmel_CG1455; PP2B 21EF; PP2B; PpD14; canA1; canA; pMY4", "gene_names_refseq": "CAN A1/PP2B; CG1455; CNA1; CaNA1; CaN; CanA1; Cana1; Can; CnA; CnnA21EF; D14; DmCanA1-100B; Dmel\\CG1455; PP2B 21EF; PP2B; PpD14; canA1; canA; pMY4", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2B catalytic subunit 1; 3.1.3.16; Calmodulin-dependent calcineurin A1 subunit", "protein_names_refseq": "CG1455-PD; CanA1-PD; calcineurin A1, isoform D; calcineurin A; calcineurin; protein phosphatase D14; protein phosphatase from PCR fragment D14", "tax_id": 7227, "disease": "focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); aortic valve stenosis (Disease Ontology:DOID:1712); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dme:Dmel_CG1455); (R-DME-2025928); (R-DME-2871809); (R-DME-4086398); (R-DME-5607763)", "pathway_count": 5, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;1321058;1331060;16110336;17569856;17569867;25589440;26109356;26109357;33300871;33925313", "class_list": "", "function": "Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (By similarity). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (By similarity). This subunit may have a role in the calmodulin activation of calcineurin (Probable). At the periactive zone of synaptic boutons at neuromuscular junctions, promotes formation of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) microdomains and subsequent synaptic vesicle reformation during Ca(2+) channel-dependent activity-dependent bulk endocytosis (ADBE) in response to strong stimulation (PubMed:33300871). This function may be fwe-dependent (PubMed:33300871)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MQN3;Q9TY69;Q9VA20", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0033192 calmodulin-dependent protein phosphatase activity;GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004723 calcium-dependent protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0008021 synaptic vesicle;GO:0005955 calcineurin complex", "go_biological_process": "GO:0097720 calcineurin-mediated signaling;GO:0030431 sleep;GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway;GO:0045088 regulation of innate immune response;GO:0071731 response to nitric oxide", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P48456-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4KES9-1", "uniprot_id": [ { "id": "A0A0B4KES9_DROME", "url": "https://www.uniprot.org/uniprot/A0A0B4KES9", "type": "external" } ], "mass": 29260.0, "length": 249, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG14589", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": [ { "id": "NP_001260721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260721", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG14589; CG14589; Dmel_CG14589", "gene_names_refseq": "CG14589; Dmel\\CG14589", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG14589-PC; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14589)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A0B4KES9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4K769-1", "uniprot_id": [ { "id": "A0A0B4K769_DROME", "url": "https://www.uniprot.org/uniprot/A0A0B4K769", "type": "external" } ], "mass": 18819.0, "length": 175, "protein_name": "Protein shisa-5", "gene_name": "BcDNA:RH03863; Dmel\\CG17574", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform I", "refseq_ac": [ { "id": "NP_001246287", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246287", "type": "external" } ], "gene_names_uniprotkb": "BcDNA:RH03863; Dmel\\CG17574; BcDNA:RH03863; CG17574; Dmel\\CG17574; Dmel_CG17574", "gene_names_refseq": "BcDNA:RH03863; CG17574; Dmel\\CG17574", "protein_names_uniprotkb": "Protein shisa-5", "protein_names_refseq": "CG17574-PI; uncharacterized protein, isoform I", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17574)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A0B4K769-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4K776-1", "uniprot_id": [ { "id": "A0A0B4K776_DROME", "url": "https://www.uniprot.org/uniprot/A0A0B4K776", "type": "external" } ], "mass": 14925.0, "length": 133, "protein_name": "Secreted protein", "gene_name": "Dmel\\CG43371", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_001246383", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246383", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG43371; CG43371; Dmel_CG43371", "gene_names_refseq": "CG43371; Dmel\\CG43371", "protein_names_uniprotkb": "Secreted protein", "protein_names_refseq": "CG43371-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG43371)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A0B4K776-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O16011-1", "uniprot_id": [ { "id": "MBL_DROME", "url": "https://www.uniprot.org/uniprot/O16011", "type": "external" } ], "mass": 32330.0, "length": 297, "protein_name": "Protein muscleblind", "gene_name": "mbl", "organism": "Fruit fly", "refseq_name": "muscleblind, isoform D", "refseq_ac": [ { "id": "NP_788390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788390", "type": "external" } ], "gene_names_uniprotkb": "mbl; BG01127; CG10941; CG14477; CG33197; Dmel\\CG33197; Dmel_CG33197; MBL; Mbl; chaste; chst; cht; l(2)01038; l(2)k01212; l(2)k05507; mb1; mbn; mm; n(2)k07110", "gene_names_refseq": "BG01127; CG10941; CG14477; CG33197; Dmel\\CG33197; MBL; Mbl; chaste; chst; cht; l(2)01038; l(2)k01212; l(2)k05507; mb1; mbl; mbn; mm; n(2)k07110", "protein_names_uniprotkb": "Protein muscleblind; Protein mindmelt", "protein_names_refseq": "BG01127; CG33197-PD; MUSCLEBLIND; chaste; mbl-PD; mindmelt; muscleblind, isoform D", "tax_id": 7227, "disease": "myotonic dystrophy type 2 (Disease Ontology:DOID:0050759); myotonic dystrophy type 1 (Disease Ontology:DOID:11722); dilated cardiomyopathy (Disease Ontology:DOID:12930); myotonic disease (Disease Ontology:DOID:450); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dme:Dmel_CG33197)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;9334280", "class_list": "", "function": "Required for terminal differentiation of photoreceptor cells. Vital for embryonic development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O16008;O16009;O16010;Q86BE8;Q9V803;Q9V804", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0030018 Z disc", "go_biological_process": "GO:0046716 muscle cell cellular homeostasis;GO:0006915 apoptotic process;GO:0007517 muscle organ development;GO:0007601 visual perception;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O16011-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77460-1", "uniprot_id": [ { "id": "IPYR_DROME", "url": "https://www.uniprot.org/uniprot/O77460", "type": "external" } ], "mass": 37939.0, "length": 338, "protein_name": "Inorganic pyrophosphatase", "gene_name": "Nurf-38", "organism": "Fruit fly", "refseq_name": "nucleosome remodeling factor - 38kD, isoform B", "refseq_ac": [ { "id": "NP_001137758", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137758", "type": "external" } ], "gene_names_uniprotkb": "Nurf-38; 38; CG4634; Dmel\\CG4634; Dmel_CG4634; N38; NURF 38; NURF-38; NURF38; NURF; Nurf 38; Nurf38; PPA1; dNURF; l(2)k16102; p38", "gene_names_refseq": "38; CG4634; Dmel\\CG4634; N38; NURF 38; NURF-38; NURF38; NURF; Nurf 38; Nurf-38; Nurf38; PPA1; dNURF; l(2)k16102; p38/NURF-38; p38", "protein_names_uniprotkb": "Inorganic pyrophosphatase; 3.6.1.1; Nucleosome-remodeling factor 38 kDa subunit; PPase; Pyrophosphate phospho-hydrolase", "protein_names_refseq": "CG4634-PB; Nurf-38-PB; inorganic pyrophosphatase 1; inorganic pyrophosphatase; nucleosome remodeling factor - 38kD, isoform B; nucleosome remodeling factor-38 kDa; pyrophosphatase", "tax_id": 7227, "disease": "myocarditis (Disease Ontology:DOID:820)", "pathway": " (dme:Dmel_CG4634); (R-DME-379716); (R-DME-379726); (R-DME-71737)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8521501;9784495", "class_list": "", "function": "Component of NURF (nucleosome remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin (PubMed:9784495). NURF is required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis (PubMed:8521501, PubMed:9784495). Inorganic pyrophosphatase (PPase), hydrolyzes inorganic pyrophosphate to inorganic phosphate, essential for driving critical biosynthetic reactions including transcription, replication, and DNA repair (PubMed:9784495)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W150", "ec_number_list": [ { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004427 inorganic diphosphate phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0016589 NURF complex", "go_biological_process": "GO:0034728 nucleosome organization;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006796 phosphate-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O77460-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27237-1", "uniprot_id": [ { "id": "DJTID_DROME", "url": "https://www.uniprot.org/uniprot/Q27237", "type": "external" } ], "mass": 56137.0, "length": 520, "protein_name": "DnaJ homolog l(2)tid, mitochondrial", "gene_name": "l(2)tid", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": [ { "id": "NP_524932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524932", "type": "external" } ], "gene_names_uniprotkb": "l(2)tid; CG5504; Dmel\\CG5504; Dmel_CG5504; DnaJ; TID56; cDNA 10D; l(2)701; l(2)tud; tid", "gene_names_refseq": "CG5504; Dmel\\CG5504; DnaJ; TID56; cDNA 10D; l(2)701; l(2)tid; l(2)tud; lethal (2) tumorous imaginal discs", "protein_names_uniprotkb": "DnaJ homolog l(2)tid, mitochondrial; Protein lethal(2)tumorous imaginal discs; TID50; TID56", "protein_names_refseq": "CG5504-PA; lethal (2) tumorous imaginal discs; lethal(2) tumorous imaginal discs; lethal(2)tumorous imaginal discs; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5504)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;12783860;16110336;17569856;17569867;25589440;26109356;26109357;29870719;7758246;9373138;9585178", "class_list": "", "function": "Involved in hh/hedgehog signaling (PubMed:12783860). May act as a tumor suppressor in larval imaginal disks (PubMed:7758246)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0F7J3E9;O02528;O02529;O02549;Q24554;Q27259;Q7KVH8;Q8T9A7;Q9W1K7", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0051082 unfolded protein binding;GO:0031072 heat shock protein binding;GO:0005113 patched binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:0006457 protein folding;GO:0007005 mitochondrion organization;GO:0009408 response to heat;GO:0045879 negative regulation of smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q27237-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P91622-1", "uniprot_id": [ { "id": "PDK_DROME", "url": "https://www.uniprot.org/uniprot/P91622", "type": "external" } ], "mass": 46626.0, "length": 413, "protein_name": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial", "gene_name": "Pdk", "organism": "Fruit fly", "refseq_name": "pyruvate dehydrogenase kinase, isoform C", "refseq_ac": [ { "id": "NP_001246224", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246224", "type": "external" } ], "gene_names_uniprotkb": "Pdk; BcDNA:LD09837; CG8808; DmPDK; DmPdk; Dmel\\CG8808; Dmel_CG8808; PDHK; PDK; pdk", "gene_names_refseq": "BcDNA:LD09837; CG8808; DmPDK; DmPdk; Dmel\\CG8808; PDHK; PDK; Pdk; pdk", "protein_names_uniprotkb": "[Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial; 2.7.11.2; DmPDK; Pyruvate dehydrogenase kinase", "protein_names_refseq": "CG8808-PC; Pdk-PC; pyruvate dehydrogenase kinase, isoform C; pyruvate dehydrogenase kinase", "tax_id": 7227, "disease": "Charcot-Marie-Tooth disease X-linked dominant 6 (Disease Ontology:DOID:0110207)", "pathway": " (dme:Dmel_CG8808); (R-DME-204174); (R-DME-5362517); (R-DME-9837999)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;9115642", "class_list": "", "function": "Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V580", "ec_number_list": [ { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.1.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.40", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "1.1.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.39", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.51", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.12", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.1.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.41", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.-.-", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.16", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" } ], "go_molecular_function": "GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045254 pyruvate dehydrogenase complex", "go_biological_process": "GO:0010906 regulation of glucose metabolic process;GO:0010510 regulation of pyruvate decarboxylation to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P91622-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06003-1", "uniprot_id": [ { "id": "GOLI_DROME", "url": "https://www.uniprot.org/uniprot/Q06003", "type": "external" } ], "mass": 52623.0, "length": 461, "protein_name": "E3 ubiquitin-protein ligase goliath", "gene_name": "gol", "organism": "Fruit fly", "refseq_name": "goliath, isoform D", "refseq_ac": [ { "id": "NP_001163300", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163300", "type": "external" } ], "gene_names_uniprotkb": "gol; CG2679; Dmel\\CG2679; Dmel_CG2679; GL; Gol; anon-G1; dgol; g1; meso", "gene_names_refseq": "CG2679; Dmel\\CG2679; Gol; anon-G1; dgol; g1; gol; meso", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase goliath; 2.3.2.27", "protein_names_refseq": "CG2679-PD; gol-PD; goliath, isoform D; goliath", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2679); (R-DME-5689880); (R-DME-5689896)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;23353890;25589440;26109356;26109357;8462875", "class_list": "", "function": "Endosomal E3 ubiquitin-protein ligase that regulates the recycling endosome pathway (PubMed:23353890). May play an indirect role in regulation of gene expression during embryonic mesoderm formation (PubMed:8462875)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E1JGX0;Q8T0M7;Q9W0W3", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0010008 endosome membrane;GO:0016020 membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0001707 mesoderm formation;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q06003-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07188-1", "uniprot_id": [ { "id": "LCP3_DROME", "url": "https://www.uniprot.org/uniprot/P07188", "type": "external" } ], "mass": 11857.0, "length": 112, "protein_name": "Larval cuticle protein 3", "gene_name": "Lcp3", "organism": "Fruit fly", "refseq_name": "larval cuticle protein 3, isoform B", "refseq_ac": [ { "id": "NP_001260803", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260803", "type": "external" } ], "gene_names_uniprotkb": "Lcp3; 3; CG2043; CP3; DMLCP3; DmelLcp3; Dmel\\CG2043; Dmel_CG2043; III; LCP-3; LCP3; L[[3]]CP3; LcpIII; lcp3", "gene_names_refseq": "3; CG2043; CP3; DMLCP3; DmelLcp3; Dmel\\CG2043; III; LCP-3; LCP3; L[[3]]CP3; Lcp3; LcpIII; lcp3", "protein_names_uniprotkb": "Larval cuticle protein 3; Larval cuticle protein III", "protein_names_refseq": "CG2043-PB; Lcp3-PB; cuticle p. III; gene III; larval cuticle protein 3, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2043)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;6817923", "class_list": "", "function": "Component of the larval cuticle., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53XF1;Q9V4T1", "ec_number_list": [], "go_molecular_function": "GO:0008010 structural constituent of chitin-based larval cuticle;GO:0042302 structural constituent of cuticle", "go_cellular_component": "GO:0062129 chitin-based extracellular matrix", "go_biological_process": "GO:0008363 larval chitin-based cuticle development;GO:0040003 chitin-based cuticle development", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P07188-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4KER0-1", "uniprot_id": [ { "id": "A0A0B4KER0_DROME", "url": "https://www.uniprot.org/uniprot/A0A0B4KER0", "type": "external" } ], "mass": 146209.0, "length": 1301, "protein_name": "Relative of woc, isoform C", "gene_name": "row", "organism": "Fruit fly", "refseq_name": "relative of woc, isoform C", "refseq_ac": [ { "id": "NP_001260992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260992", "type": "external" } ], "gene_names_uniprotkb": "row; CG8092; Dmel\\CG8092; Dmel_CG8092; ROW; Row; anon-WO0118547.194", "gene_names_refseq": "CG8092; Dmel\\CG8092; ROW; Row; anon-WO0118547.194; row", "protein_names_uniprotkb": "Relative of woc, isoform C", "protein_names_refseq": "CG8092-PC; Relative-of-WOC; relative of woc, isoform C; row-PC", "tax_id": 7227, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); White-Sutton syndrome (Disease Ontology:DOID:0070067); intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (dme:Dmel_CG8092)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A0B4KER0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1ZA47-1", "uniprot_id": [ { "id": "ZASP_DROME", "url": "https://www.uniprot.org/uniprot/A1ZA47", "type": "external" } ], "mass": 238063.0, "length": 2194, "protein_name": "PDZ and LIM domain protein Zasp", "gene_name": "Zasp52", "organism": "Fruit fly", "refseq_name": "Z band alternatively spliced PDZ-motif protein 52, isoform F", "refseq_ac": [ { "id": "NP_001027420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027420", "type": "external" } ], "gene_names_uniprotkb": "Zasp52; CG12968; CG12969; CG30084; CG8242; Dmel\\CG30084; Dmel_CG30084; Z(210); ZASP52; ZASP; Zasp; Zbp210; dzasp; tun; zasp52; zasp", "gene_names_refseq": "CG12968; CG12969; CG30084; CG8242; Dmel\\CG30084; Z(210); ZASP52; ZASP; Zasp52; Zasp; Zbp210; dzasp; tun; zasp52; zasp", "protein_names_uniprotkb": "PDZ and LIM domain protein Zasp; Z band alternatively spliced PDZ-motif protein", "protein_names_refseq": "CG30084-PF; Z band alternatively spliced PDZ-motif containing protein 52; Z band alternatively spliced PDZ-motif protein 52, isoform F; Z band alternatively spliced PDZ-motif protein; Z-band-protein-210; Zasp52-PF; tungus; zetalin", "tax_id": 7227, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); myofibrillar myopathy 1 (Disease Ontology:DOID:0080092); myofibrillar myopathy 4 (Disease Ontology:DOID:0080095); congenital myopathy (Disease Ontology:DOID:0081337); dilated cardiomyopathy 1C (Disease Ontology:DOID:0110423); distal myopathy (Disease Ontology:DOID:11720); myotonic dystrophy type 1 (Disease Ontology:DOID:11722); dilated cardiomyopathy (Disease Ontology:DOID:12930); myopathy (Disease Ontology:DOID:423)", "pathway": " (dme:Dmel_CG30084)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18166658;25589440;26109356;26109357;33925313", "class_list": "", "function": "Regulator of cell matrix adhesion having two related functions, one upstream of Actn organizing the Z line and the other downstream of integrins regulating assembly of integrin adhesion sites. Also required for the formation of myotendinous junctions in muscles., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 9, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A1ZA48;A1ZA49;A8DYF3;B0EW00;Q4V6Y5;Q6NNA6;Q86NZ1;Q8IGJ7", "ec_number_list": [], "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0042805 actinin binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005912 adherens junction;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton;GO:0016323 basolateral plasma membrane;GO:0031252 cell leading edge", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0001952 regulation of cell-matrix adhesion;GO:0030239 myofibril assembly;GO:0061061 muscle structure development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "A1ZA47-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P91623-1", "uniprot_id": [ { "id": "GATAC_DROME", "url": "https://www.uniprot.org/uniprot/P91623", "type": "external" } ], "mass": 50634.0, "length": 486, "protein_name": "GATA-binding factor C", "gene_name": "grn", "organism": "Fruit fly", "refseq_name": "grain, isoform A", "refseq_ac": [ { "id": "NP_731211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_731211", "type": "external" } ], "gene_names_uniprotkb": "grn; CG9656-PA; CG9656; Dmel\\CG9656; Dmel_CG9656; GATAc; GRAIN; Gata-c; Gata2; Grn; dGATA-2; dGATAc; dGatac; gra; l(3)84Fa", "gene_names_refseq": "CG9656-PA; CG9656; Dmel\\CG9656; GATAc; GRAIN; Gata-c; Gata2; Grn; dGATA-2; dGATAc; dGatac; gra; grn; l(3)84Fa", "protein_names_uniprotkb": "GATA-binding factor C; Protein grain; Transcription factor GATA-C; dGATA-C", "protein_names_refseq": "CG9656-PA; GATA-factor-c; grain, isoform A; grain; grn-PA; lethal(3)84Fa", "tax_id": 7227, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); colitis (Disease Ontology:DOID:0060180); hypoparathyroidism-retardation-dysmorphism syndrome (Disease Ontology:DOID:0060348); hypoparathyroidism-deafness-renal disease syndrome (Disease Ontology:DOID:0060878); immunodeficiency 21 (Disease Ontology:DOID:0111947); sensorineural hearing loss (Disease Ontology:DOID:10003); pre-eclampsia (Disease Ontology:DOID:10591); hypoparathyroidism (Disease Ontology:DOID:11199); aplastic anemia (Disease Ontology:DOID:12449); depressive disorder (Disease Ontology:DOID:1596); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); autoimmune thyroiditis (Disease Ontology:DOID:7188); myeloid leukemia (Disease Ontology:DOID:8692); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (dme:Dmel_CG9656); (R-DME-5689880); (R-DME-8936459); (R-DME-8939236); (R-DME-9018519); (R-DME-983231)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;7559649", "class_list": "", "function": "Transcription factor that is vital to the development of multiple organ systems. Binds to the core consensus sequence 5'-WGATAR-3'., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9VHV4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0009887 animal organ morphogenesis;GO:0009888 tissue development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P91623-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24451-1", "uniprot_id": [ { "id": "MAN2_DROME", "url": "https://www.uniprot.org/uniprot/Q24451", "type": "external" } ], "mass": 126721.0, "length": 1108, "protein_name": "Alpha-mannosidase 2", "gene_name": "alpha-Man-IIa", "organism": "Fruit fly", "refseq_name": "alpha-Mannosidase class II a, isoform A", "refseq_ac": [ { "id": "NP_524291", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524291", "type": "external" } ], "gene_names_uniprotkb": "alpha-Man-IIa; CG18474; CG18802; CG8139; DM-GII.1; Dmel\\CG18802; Dmel_CG18802; GMII; GmII; MAN-2; Man-II; Man; agr:-Man-II; alpha-Man-IIA; alpha-Man-IIalpha; alpha-Man-II; dGMIIb; dGMII", "gene_names_refseq": "-Man-II; CG18474; CG18802; CG8139; DM-GII.1; Dmel\\CG18802; GMII; GmII; MAN-2; Man-II; Man; agr; alpha-Man-IIA; alpha-Man-IIalpha; alpha-Man-IIa; alpha-Man-II; dGMIIb; dGMII", "protein_names_uniprotkb": "Alpha-mannosidase 2; 3.2.1.114; AMan II; Golgi alpha-mannosidase IIa; Golgi alpha-mannosidase II; Man II; Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase", "protein_names_refseq": "CG18802-PA; alpha mannosidase II; alpha-Man-IIa-PA; alpha-Mannosidase class II a, isoform A; alpha-mannosidase 2; alpha-mannosidase II; alpha-mannosidase-II; chain A, golgi Alpha-Mannosidase Ii; golgi Man II; golgi alpha-mannosidase II; golgi alpha-mannosidase; golgi mannosidase II", "tax_id": 7227, "disease": "congenital dyserythropoietic anemia (Disease Ontology:DOID:1338); schizophrenia (Disease Ontology:DOID:5419); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (dme:Dmel_CG18802); (R-DME-975578)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10504337;10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;7890162", "class_list": "glycogene;glycosylhydrolase", "function": "Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9TYG5;Q9VHD8;Q9VHD9", "ec_number_list": [ { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.114", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.114", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004559 alpha-mannosidase activity;GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity;GO:0015923 mannosidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005795 Golgi stack", "go_biological_process": "GO:0006491 N-glycan processing;GO:0006013 mannose metabolic process;GO:1904381 Golgi apparatus N-glycan mannose trimming;GO:0016063 rhodopsin biosynthetic process;GO:0035010 encapsulation of foreign target", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q24451-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.1000000001000.101.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26270-1", "uniprot_id": [ { "id": "PSMD7_DROME", "url": "https://www.uniprot.org/uniprot/P26270", "type": "external" } ], "mass": 38089.0, "length": 338, "protein_name": "26S proteasome non-ATPase regulatory subunit 7", "gene_name": "Rpn8", "organism": "Fruit fly", "refseq_name": "regulatory particle non-ATPase 8, isoform C", "refseq_ac": [ { "id": "NP_001261168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261168", "type": "external" } ], "gene_names_uniprotkb": "Rpn8; CG3416; Dmel\\CG3416; Dmel_CG3416; Mov34; P26270; PRSC_DROME; PSMD7; RPN8; S12; l(2)k08003; mov34; p39B", "gene_names_refseq": "CG3416; Dmel\\CG3416; Mov34; P26270; PRSC_DROME; PSMD7; RPN8; Rpn8; S12; l(2)k08003; mov34; p39B", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 7; 26S proteasome regulatory subunit RPN8; 26S proteasome regulatory subunit S12; Proteasome subunit p39B; Proteasome subunit p40; Protein Mov34", "protein_names_refseq": "CG3416-PC; Mov34; Rpn8-PC; regulatory particle non-ATPase 8, isoform C", "tax_id": 7227, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); neurodegenerative disease (Disease Ontology:DOID:1289); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (dme:Dmel_CG3416); (R-DME-1169091); (R-DME-1234176); (R-DME-1236978); (R-DME-174084); (R-DME-174154); (R-DME-174178); (R-DME-174184); (R-DME-187577); (R-DME-195253); (R-DME-202424); (R-DME-209360); (R-DME-209406); (R-DME-209461); (R-DME-216167); (R-DME-2467813); (R-DME-2871837); (R-DME-350562); (R-DME-382556); (R-DME-432395); (R-DME-432524); (R-DME-432626); (R-DME-450408); (R-DME-4608870); (R-DME-4641257); (R-DME-4641258); (R-DME-5358346); (R-DME-538864); (R-DME-5607761); (R-DME-5607764); (R-DME-5610780); (R-DME-5610785); (R-DME-5632684); (R-DME-5658442); (R-DME-5676590); (R-DME-5689603); (R-DME-5689880); (R-DME-6798695); (R-DME-68867); (R-DME-68949); (R-DME-69017); (R-DME-69601); (R-DME-75815); (R-DME-8854050); (R-DME-8939236); (R-DME-8939902); (R-DME-8941858); (R-DME-8948751); (R-DME-8951664); (R-DME-9020702); (R-DME-9755511); (R-DME-9762114); (R-DME-983168); (R-DME-9907900); (R-DME-9929491); (R-DME-9932298); (R-DME-9954709)", "pathway_count": 57, "publication_count": 46, "publication_id_list": "10102270;10417378;10458606;10481010;10731132;10893261;11585911;12231619;12432393;12442174;12537568;12537569;12537572;12537573;12537574;12973300;15178801;15258584;15331761;16110336;16139204;16299518;16326393;16386907;16543224;16603629;16651542;16740475;16794082;17102630;17569856;17569867;17925225;18519643;18593878;19185492;2209467;25589440;26109356;26109357;7705656;8948598;9025065;9215627;9553105;9990853", "class_list": "", "function": "Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W178", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0030425 dendrite;GO:0000502 proteasome complex;GO:0008541 proteasome regulatory particle, lid subcomplex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 4.7, "record_id": "P26270-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04357-1", "uniprot_id": [ { "id": "MT1_DROME", "url": "https://www.uniprot.org/uniprot/P04357", "type": "external" } ], "mass": 3853.0, "length": 40, "protein_name": "Metallothionein-1", "gene_name": "MtnA", "organism": "Fruit fly", "refseq_name": "metallothionein A, isoform B", "refseq_ac": [ { "id": "NP_001262438", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262438", "type": "external" } ], "gene_names_uniprotkb": "MtnA; BcDNA:GH18460; CG9470; Dmel\\CG9470; Dmel_CG9470; DrosMtn; MTA; MTN; MT; Mtn; anon-WO0153538.42; anon-WO0153538.44; anon-WO0153538.49; mtnA; mtna", "gene_names_refseq": "BcDNA:GH18460; CG9470; Dmel\\CG9470; DrosMtn; MTA; MTN; MT; MtnA; Mtn; anon-WO0153538.42; anon-WO0153538.44; anon-WO0153538.49; mtnA; mtna", "protein_names_uniprotkb": "Metallothionein-1; MT-1", "protein_names_refseq": "CG9470-PB; MtnA-PB; metallothionein A, isoform B; metallothionein A; metallothionein N; metallothionein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9470)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;1802803;18670138;1976815;25589440;2578462;26109356;26109357;2822463;3007277;3086075", "class_list": "", "function": "This protein binds cations of several transition elements. It is thought to be involved in detoxification processes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5T1U3;B5T1U5;Q9VH67", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0010038 response to metal ion;GO:0140961 cellular detoxification of metal ion", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P04357-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q23971-1", "uniprot_id": [ { "id": "OSC_DROME", "url": "https://www.uniprot.org/uniprot/Q23971", "type": "external" } ], "mass": 14917.0, "length": 135, "protein_name": "Antennal-specific protein OS-C", "gene_name": "Os-C", "organism": "Fruit fly", "refseq_name": "Os-C, isoform C", "refseq_ac": [ { "id": "NP_649753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649753", "type": "external" } ], "gene_names_uniprotkb": "Os-C; CG3250; Dmel\\CG3250; Dmel_CG3250; OS-C; Os-c", "gene_names_refseq": "CG3250; Dmel\\CG3250; OS-C; Os-C; Os-c", "protein_names_uniprotkb": "Antennal-specific protein OS-C", "protein_names_refseq": "CG3250-PC; Os-C, isoform C; Os-C-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3250)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8206941", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C9QNY5;Q9VHX8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q23971-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05130-1", "uniprot_id": [ { "id": "KPC1_DROME", "url": "https://www.uniprot.org/uniprot/P05130", "type": "external" } ], "mass": 77695.0, "length": 679, "protein_name": "Protein kinase C, brain isozyme", "gene_name": "Pkc53E", "organism": "Fruit fly", "refseq_name": "protein C kinase 53E, isoform F", "refseq_ac": [ { "id": "NP_001261035", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261035", "type": "external" } ], "gene_names_uniprotkb": "Pkc53E; CG6622; DPKC; Dmel\\CG6622; Dmel_CG6622; Dpkc1; PK-C; PKC 53B; PKC 53E; PKC-53B; PKC-53E; PKC1; PKC53E; PKC53e; PKC; Pkc1; dPKC53E(br); dPKC; pck53E; pkc53E; pkc53e", "gene_names_refseq": "CG6622; DPKC; Dmel\\CG6622; Dpkc1; PK-C; PKC 53B; PKC 53E; PKC-53B; PKC-53E; PKC1; PKC53E; PKC53e; PKC; Pkc1; Pkc53E; dPKC53E(br); dPKC; pck53E; pkc53E; pkc53e", "protein_names_uniprotkb": "Protein kinase C, brain isozyme; 2.7.11.13; PKC; dPKC53E(BR)", "protein_names_refseq": "CG6622-PF; Pkc53E-PF; protein C kinase 53E, isoform F; protein kinase C; protein kinase-C 53E; protein kinase-c1", "tax_id": 7227, "disease": "spinocerebellar ataxia 14 (Disease Ontology:DOID:0050964); ductal carcinoma in situ (Disease Ontology:DOID:0060074); prostate carcinoma (Disease Ontology:DOID:10286); silicosis (Disease Ontology:DOID:10325); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); dilated cardiomyopathy (Disease Ontology:DOID:12930); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); endometrial carcinoma (Disease Ontology:DOID:2871); high grade glioma (Disease Ontology:DOID:3070); ischemia (Disease Ontology:DOID:326); middle cerebral artery infarction (Disease Ontology:DOID:3525); chordoid glioma (Disease Ontology:DOID:3774); lung non-small cell carcinoma (Disease Ontology:DOID:3908); ovarian carcinoma (Disease Ontology:DOID:4001); hyperglycemia (Disease Ontology:DOID:4195); large cell carcinoma (Disease Ontology:DOID:4552); congestive heart failure (Disease Ontology:DOID:6000); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG6622); (R-DME-111933); (R-DME-114516); (R-DME-1169091); (R-DME-1250196); (R-DME-1433559); (R-DME-2179392); (R-DME-3000170); (R-DME-399997); (R-DME-416993); (R-DME-4419969); (R-DME-450520); (R-DME-5218921); (R-DME-76005)", "pathway_count": 14, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;25639794;26109356;26109357;3107983", "class_list": "", "function": "PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins (By similarity). PKC also serves as the receptor for phorbol esters, a class of tumor promoters (By similarity). Acts in a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V7V6;Q9V7V7", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.16", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:2000370 positive regulation of clathrin-dependent endocytosis;GO:0035206 regulation of hemocyte proliferation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P05130-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03427-1", "uniprot_id": [ { "id": "LMNA_DROME", "url": "https://www.uniprot.org/uniprot/Q03427", "type": "external" } ], "mass": 69860.0, "length": 621, "protein_name": "Lamin-C", "gene_name": "LamC", "organism": "Fruit fly", "refseq_name": "lamin C, isoform A", "refseq_ac": [ { "id": "NP_523742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523742", "type": "external" } ], "gene_names_uniprotkb": "LamC; CG10119; DmC; Dmel\\CG10119; Dmel_CG10119; G-IF; LAMC; lamC; lamin C; pG-IF", "gene_names_refseq": "CG10119; DmC; Dmel\\CG10119; G-IF; LAMC; LamC; lamC; lamin C; pG-IF", "protein_names_uniprotkb": "Lamin-C; pG-IF", "protein_names_refseq": "CG10119-PA; G intermediate filament; LamC-PA; Lamin-C; LaminC; lamin A; lamin C, isoform A; lamin C; lamin DmC", "tax_id": 7227, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); familial partial lipodystrophy (Disease Ontology:DOID:0050440); congenital muscular dystrophy (Disease Ontology:DOID:0050557); atrioventricular block (Disease Ontology:DOID:0050820); autosomal dominant primary microcephaly 26 (Disease Ontology:DOID:0051037); autosomal dominant primary microcephaly 27 (Disease Ontology:DOID:0051038); typical adult-onset autosomal dominant demyelinating leukodystrophy (Disease Ontology:DOID:0060785); familial partial lipodystrophy type 2 (Disease Ontology:DOID:0070202); autosomal dominant Emery-Dreifuss muscular dystrophy 2 (Disease Ontology:DOID:0070247); autosomal recessive Emery-Dreifuss muscular dystrophy 3 (Disease Ontology:DOID:0070248); restrictive dermopathy 2 (Disease Ontology:DOID:0070370); partial lipodystrophy (Disease Ontology:DOID:0080299); aortic valve disease 2 (Disease Ontology:DOID:0080334); mandibuloacral dysplasia type A lipodystrophy (Disease Ontology:DOID:0081128); Charcot-Marie-Tooth disease type 2B1 (Disease Ontology:DOID:0110156); dilated cardiomyopathy 1A (Disease Ontology:DOID:0110425); congenital muscular dystrophy due to LMNA mutation (Disease Ontology:DOID:0110640); progressive myoclonus epilepsy 9 (Disease Ontology:DOID:0111450); dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome (Disease Ontology:DOID:0111584); otitis media (Disease Ontology:DOID:10754); lipoatrophic diabetes mellitus (Disease Ontology:DOID:11712); Emery-Dreifuss muscular dystrophy (Disease Ontology:DOID:11726); dilated cardiomyopathy (Disease Ontology:DOID:12930); transient cerebral ischemia (Disease Ontology:DOID:224); arteriosclerosis (Disease Ontology:DOID:2349); progeria (Disease Ontology:DOID:3911); myopathy (Disease Ontology:DOID:423); Werner syndrome (Disease Ontology:DOID:5688); muscle tissue disease (Disease Ontology:DOID:66); cerebrovascular disease (Disease Ontology:DOID:6713); lipodystrophy (Disease Ontology:DOID:811); achalasia (Disease Ontology:DOID:9164); type 2 diabetes mellitus (Disease Ontology:DOID:9352); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (dme:Dmel_CG10119); (R-DME-352238); (R-DME-4419969); (R-DME-9035034)", "pathway_count": 4, "publication_count": 23, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15996653;16110336;16439308;17569856;17569867;18327897;18723885;21989239;22393432;25589440;26109356;26109357;27402967;40245499;7593280;8082654;8314904", "class_list": "", "function": "Component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin (By similarity). Involved in the organization and spacing of nuclear pore complexes on the nucleus surface; complements Lam (PubMed:15996653). In spermatocytes, regulates cytokinesis during meiosis (PubMed:27402967)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 5, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 5, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 5, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 34, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q24374;Q9V729", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0034399 nuclear periphery;GO:0005652 nuclear lamina;GO:0005638 lamin filament;GO:0070732 spindle envelope", "go_biological_process": "GO:0090435 protein localization to nuclear envelope;GO:0006325 chromatin organization;GO:0006998 nuclear envelope organization;GO:0030833 regulation of actin filament polymerization;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "Q03427-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0B4KG66-1", "uniprot_id": [ { "id": "A0A0B4KG66_DROME", "url": "https://www.uniprot.org/uniprot/A0A0B4KG66", "type": "external" } ], "mass": 74283.0, "length": 672, "protein_name": "2.7.11.1; 2.7.12.1; Monopolar spindle 1, isoform B", "gene_name": "Mps1", "organism": "Fruit fly", "refseq_name": "monopolar spindle 1, isoform B", "refseq_ac": [ { "id": "NP_001262677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262677", "type": "external" } ], "gene_names_uniprotkb": "Mps1; Ald; CG7643; Dmel\\CG7643; Dmel_CG7643; Mps1; Msp1; TKK; ald; dMps1; mps1", "gene_names_refseq": "Ald/Mps1; Ald; CG7643; Dmel\\CG7643; Mps1; Msp1; TKK; ald; dMps1; mps1", "protein_names_uniprotkb": "2.7.11.1; 2.7.12.1; Monopolar spindle 1, isoform B", "protein_names_refseq": "CG7643-PB; Mps1-PB; altered disjunction; monopolar spindle 1, isoform B; monopolar spindles 1", "tax_id": 7227, "disease": "cancer (Disease Ontology:DOID:162); bipolar disorder (Disease Ontology:DOID:3312); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dme:Dmel_CG7643)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004712 protein serine/threonine/tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0000776 kinetochore;GO:0000940 outer kinetochore", "go_biological_process": "GO:0048133 male germ-line stem cell asymmetric division;GO:0016321 female meiosis chromosome segregation;GO:0033316 meiotic spindle assembly checkpoint signaling;GO:0007059 chromosome segregation;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A0B4KG66-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P91928-1", "uniprot_id": [ { "id": "MIC60_DROME", "url": "https://www.uniprot.org/uniprot/P91928", "type": "external" } ], "mass": 82014.0, "length": 739, "protein_name": "MICOS complex subunit Mic60", "gene_name": "Mitofilin", "organism": "Fruit fly", "refseq_name": "mitofilin, isoform D", "refseq_ac": [ { "id": "NP_001262818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262818", "type": "external" } ], "gene_names_uniprotkb": "Mitofilin; A0A0B4KGN2; CG 6455; CG6455; Dmel\\CG6455; Dmel_CG6455; MIC60; dIMMT; dMIC60; dMic60; mitofilin", "gene_names_refseq": "A0A0B4KGN2; CG 6455; CG6455; Dmel\\CG6455; MIC60; Mitofilin; dIMMT; dMIC60; dMic60; mitofilin", "protein_names_uniprotkb": "MICOS complex subunit Mic60", "protein_names_refseq": "CG6455-PD; MICOS complex subunit MIC60; Mitofilin-PD; Motor-protein; dmitofilin; mitofilin, isoform D; motor protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6455)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10071211;10731132;10731138;12537568;12537572;12537573;12537574;16110336;17569856;17569867;24998521;25589440;26109356;26109357", "class_list": "", "function": "Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8IN13;Q9V3K0", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0043008 ATP-dependent protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0044284 mitochondrial crista junction;GO:0061617 MICOS complex", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0042407 cristae formation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P91928-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25724-1", "uniprot_id": [ { "id": "NANOS_DROME", "url": "https://www.uniprot.org/uniprot/P25724", "type": "external" } ], "mass": 43428.0, "length": 401, "protein_name": "Protein nanos", "gene_name": "nanos", "organism": "Fruit fly", "refseq_name": "nanos, isoform A", "refseq_ac": [ { "id": "NP_476658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476658", "type": "external" } ], "gene_names_uniprotkb": "nanos; CG5637; DRONANOS; Dmel\\CG5637; Dmel_CG5637; Dronanos; NANOS; NOS; Nanos; Nos; l(3)07117; l(3)j3B6; l(3)j4B6; nNOS; nos", "gene_names_refseq": "CG5637; DRONANOS; Dmel\\CG5637; Dronanos; NANOS; NOS; Nanos; Nos; l(3)07117; l(3)j3B6; l(3)j4B6; nNOS; nanos; nos", "protein_names_uniprotkb": "Protein nanos", "protein_names_refseq": "CG5637-PA; nanos, isoform A; nanos-PA", "tax_id": 7227, "disease": "spermatogenic failure 12 (Disease Ontology:DOID:0070171)", "pathway": " (dme:Dmel_CG5637)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10541556;10581288;10731132;11060247;11274060;11700288;12537568;12537572;12537573;12537574;16110336;17178403;17569856;17569867;1908748;19470484;22438571;25589440;26109356;26109357;26968986;9049312", "class_list": "", "function": "Maternal RNA-binding protein that is required for germ cells proliferation and self-renewal. Acts by forming a complex with pum and brat that regulates translation and mRNA stability. The complex binds to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR and prevents its translation. Controls posterior development. Rescuing factor for the abdominal defect of posterior group mutants. The other posterior group genes are not required for nanos function but rather play a role in localization or distribution of nanos protein., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 17, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VDZ6", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0031594 neuromuscular junction;GO:0048471 perinuclear region of cytoplasm;GO:0071598 neuronal ribonucleoprotein granule;GO:0045495 pole plasm;GO:0098975 postsynapse of neuromuscular junction", "go_biological_process": "GO:0007283 spermatogenesis;GO:0043066 negative regulation of apoptotic process;GO:0035282 segmentation;GO:0017148 negative regulation of translation;GO:0048813 dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P25724-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19334-1", "uniprot_id": [ { "id": "TRP_DROME", "url": "https://www.uniprot.org/uniprot/P19334", "type": "external" } ], "mass": 142594.0, "length": 1275, "protein_name": "Transient receptor potential protein", "gene_name": "trp", "organism": "Fruit fly", "refseq_name": "transient receptor potential, isoform A", "refseq_ac": [ { "id": "NP_476768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476768", "type": "external" } ], "gene_names_uniprotkb": "trp; 559; CG7875; DmTRP; Dmel\\CG7875; Dmel_CG7875; TRP; Trp; dTRPC1; dTRP; dTrp; gene B; idl-B", "gene_names_refseq": "559; CG7875; DmTRP; Dmel\\CG7875; TRP; Trp; dTRPC1; dTRP; dTrp; gene B; idl-B; trp", "protein_names_uniprotkb": "Transient receptor potential protein", "protein_names_refseq": "CG7875-PA; Cosens-Manning mutant; INAD localization-B; transient photreceptor potential; transient receptor potential protein; transient receptor potential, isoform A; transient receptor potential; trp-PA", "tax_id": 7227, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); stomach cancer (Disease Ontology:DOID:10534); neurodegenerative disease (Disease Ontology:DOID:1289); lung cancer (Disease Ontology:DOID:1324); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dme:Dmel_CG7875); (R-DME-3295583); (R-DME-5578775); (R-DME-983695)", "pathway_count": 4, "publication_count": 26, "publication_id_list": "10366618;10632594;10731132;10766855;10896160;10908615;10995445;11707492;12107168;12537568;12537572;12537573;12537574;16110336;17569856;17569867;2482778;2516726;25589440;26109356;26109357;3118483;7751943;9010208;9215637;9930700", "class_list": "", "function": "A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Ca(2+) influx may then feed back and inhibit PLC, thereby facilitating phosphatidylinositol 4,5 bisphosphate (PIP2) recycling. Trp and trpl act together in the light response, though it is unclear whether as heteromultimers or as distinct units, and are activated by fatty acids and metabolic stress. Also required for olfactory adaptation and may be involved in olfactory system development., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7YU76;Q9VAE1", "ec_number_list": [], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016028 rhabdomere;GO:0016027 inaD signaling complex", "go_biological_process": "GO:0071454 cellular response to anoxia;GO:0055085 transmembrane transport;GO:0006816 calcium ion transport;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0007603 phototransduction, visible light", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P19334-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25867-1", "uniprot_id": [ { "id": "UBCD1_DROME", "url": "https://www.uniprot.org/uniprot/P25867", "type": "external" } ], "mass": 16678.0, "length": 147, "protein_name": "Ubiquitin-conjugating enzyme E2-17 kDa", "gene_name": "eff", "organism": "Fruit fly", "refseq_name": "effete, isoform B", "refseq_ac": [ { "id": "NP_001262578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262578", "type": "external" } ], "gene_names_uniprotkb": "eff; 3527; 6535; CG7425; Dmel\\CG7425; Dmel_CG7425; E(Pc)88D; E2; EFF; Eff; SS3-3; UBC4; UBCD-1; UBCD1; Ubc-D1; Ubc5; UbcD1; UbcD; UbcH5; anon-WO0118547.343; fs(3)01295; l(3)01462; l(3)j2C8; l(3)s1782; mei68; ms(3)01295; ms(3)1; ms(3)3; ms(3)88D; ms(3)neo2; ms(3)ry1; ms(3)ry3; ubcD1", "gene_names_refseq": "3527; 6535; CG7425; Dmel\\CG7425; E(Pc)88D; E2; EFF; Eff; SS3-3; UBC4; UBCD-1; UBCD1; Ubc-D1; Ubc5; UbcD1; UbcD; UbcH5; anon-WO0118547.343; eff; fs(3)01295; l(3)01462; l(3)j2C8; l(3)s1782; mei68; ms(3)01295; ms(3)1; ms(3)3; ms(3)88D; ms(3)neo2; ms(3)ry1; ms(3)ry3; ubcD1", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2-17 kDa; 2.3.2.23; E2 ubiquitin-conjugating enzyme D1; Protein effete; Ubiquitin carrier protein; Ubiquitin-protein ligase", "protein_names_refseq": "CG7425-PB; eff-PB; effete, isoform B; effete; effette; meiotic 68; suppressor of GMR-sina 3-3; ubiquitin conjugating enzyme 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7425); (R-DME-1234176); (R-DME-141430); (R-DME-174048); (R-DME-174084); (R-DME-174154); (R-DME-174178); (R-DME-174184); (R-DME-176407); (R-DME-176408); (R-DME-176409); (R-DME-176412); (R-DME-179409); (R-DME-201451); (R-DME-202424); (R-DME-209360); (R-DME-209461); (R-DME-2173795); (R-DME-2467813); (R-DME-2559582); (R-DME-2871837); (R-DME-5357905); (R-DME-5607764); (R-DME-5689896); (R-DME-68867); (R-DME-69017); (R-DME-8866652); (R-DME-8866654); (R-DME-8951664); (R-DME-9033241); (R-DME-983168); (R-DME-9954709); (R-DME-9954716)", "pathway_count": 33, "publication_count": 22, "publication_id_list": "10102270;10458606;10731132;12231619;12537568;12537569;12537572;12537573;12537574;1310935;16110336;16299518;16326393;16386907;17569856;17569867;17925225;25589440;26109356;26109357;9106658;9215627", "class_list": "", "function": "Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Required for proper telomere behavior during cell divisions and possibly for ubiquitination of proteins involved in postmeiotic stages of spermatogenesis. Deletion mutations are lethal in homozygotes., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VFG6", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.1.1.356", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.356", "type": "external" }, { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "2.1.1.371", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.371", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.369", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.369", "type": "external" }, { "id": "2.1.1.368", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.368", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "5.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.5", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0097039 protein linear polyubiquitination;GO:0000278 mitotic cell cycle;GO:0016322 neuron remodeling;GO:0031647 regulation of protein stability;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P25867-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30975-1", "uniprot_id": [ { "id": "TLR2_DROME", "url": "https://www.uniprot.org/uniprot/P30975", "type": "external" } ], "mass": 58396.0, "length": 519, "protein_name": "Tachykinin-like peptides receptor 99D", "gene_name": "TkR99D", "organism": "Fruit fly", "refseq_name": "Tachykinin-like receptor at 99D, isoform A", "refseq_ac": [ { "id": "NP_524556", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524556", "type": "external" } ], "gene_names_uniprotkb": "TkR99D; CG7887; DTKR; DmTRPR; Dmel\\CG7887; Dmel_CG7887; Dtkr; TAKR99D; TAKR; TKR99D; TLR2_DROME; Tak-r; TakR99D; Takr99D; Tk-R 99D; Tkr99D; anon-WO0131005.11; anon-WO0131005.9; dtkr; l(3)s2222", "gene_names_refseq": "CG7887; DTKR; DmTRPR; Dmel\\CG7887; Dtkr; TAKR99D; TAKR; TKR99D; TLR2_DROME; Tak-r; TakR99D; Takr99D; Tk-R 99D; TkR99D; Tkr99D; anon-WO0131005.11; anon-WO0131005.9; dtkr; l(3)s2222", "protein_names_uniprotkb": "Tachykinin-like peptides receptor 99D; Tachykinin-like receptor at 99D; dTKR", "protein_names_refseq": "CG7887-PA; DTK receptor; Tachykinin-like receptor at 99D, isoform A; TkR99D-PA; drosophila tachykinin receptor; tachykinin receptor; tachykinin-like receptor at 99D", "tax_id": 7227, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); developmental disorder of mental health (Disease Ontology:DOID:0060037); colitis (Disease Ontology:DOID:0060180); exercise-induced bronchoconstriction (Disease Ontology:DOID:0080821); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); hypogonadotropic hypogonadism 11 with or without anosmia (Disease Ontology:DOID:0090071); hypertension (Disease Ontology:DOID:10763); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); cystitis (Disease Ontology:DOID:1679); asthma (Disease Ontology:DOID:2841); allergic rhinitis (Disease Ontology:DOID:4481); pancreatitis (Disease Ontology:DOID:4989); pulmonary hypertension (Disease Ontology:DOID:6432); central sleep apnea (Disease Ontology:DOID:9220); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (dme:Dmel_CG7887)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;1717263;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Receptor for tachykinin-like peptides., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8T0S8;Q9VAD2", "ec_number_list": [], "go_molecular_function": "GO:0008188 neuropeptide receptor activity;GO:0004995 tachykinin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0042048 olfactory behavior;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0050805 negative regulation of synaptic transmission;GO:0007217 tachykinin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P30975-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20483-1", "uniprot_id": [ { "id": "MPIP_DROME", "url": "https://www.uniprot.org/uniprot/P20483", "type": "external" } ], "mass": 54095.0, "length": 479, "protein_name": "M-phase inducer phosphatase", "gene_name": "stg", "organism": "Fruit fly", "refseq_name": "string, isoform B", "refseq_ac": [ { "id": "NP_001263066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263066", "type": "external" } ], "gene_names_uniprotkb": "stg; 02; 03; 05; 06; 08; 13; 22; 5473; CDC25[string]; CDC25; CG1395; Cdc25[Stg]; Cdc25[String]; Cdc25[stg]; Cdc25[string]; Cdc25c; Cdc25; Dmel\\CG1395; Dmel_CG1395; EP1213; S(rux)3A; STG; SY3-4; Stg; anon-EST:Liang-2.21; cdc25[string]; cdc25; clone 2.21; l(3)01235; l(3)j10B9; l(3)j1D3; l(3)j1E3; l(3)j3D1; l(3)s2213; stg[cdc25]; string; st", "gene_names_refseq": "0224/06; 0245/03; 0439/22; 0730/13; 0896/05; 0967/05; 0980/06; 1083/13; 1089/08; 1143/02; 5473; CDC25[string]; CDC25; CG1395; Cdc25[Stg]; Cdc25[String]; Cdc25[stg]; Cdc25[string]; Cdc25c; Cdc25; Dmel\\CG1395; EP1213; S(rux)3A; STG; SY3-4; Stg/Cdc25; Stg; String/Cdc25; anon-EST:Liang-2.21; cdc25/string; cdc25[string]; cdc25; clone 2.21; l(3)01235; l(3)j10B9; l(3)j1D3; l(3)j1E3; l(3)j3D1; l(3)s2213; stg[cdc25]; stg; str/cdc25; st", "protein_names_uniprotkb": "M-phase inducer phosphatase; 3.1.3.48; Cdc25-like protein; Protein string", "protein_names_refseq": "CG1395-PB; Cdc25; String/Cdc25 phosphatase; cdc25/string; stg-PB; string, isoform B; string/cdc25; string; suppressor of rux 3A", "tax_id": 7227, "disease": "endometrial hyperplasia (Disease Ontology:DOID:0080365); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); vulva squamous cell carcinoma (Disease Ontology:DOID:2101); breast carcinoma (Disease Ontology:DOID:3459); cervical cancer (Disease Ontology:DOID:4362)", "pathway": " (dme:Dmel_CG1395); (R-DME-156711); (R-DME-176187); (R-DME-5625740); (R-DME-5689880); (R-DME-69200); (R-DME-69202); (R-DME-69273); (R-DME-69601); (R-DME-69656); (R-DME-75035)", "pathway_count": 11, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;2120044;25589440;26109356;26109357;2702688;38944657", "class_list": "", "function": "This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate Cdk1 and activate the Cdk1 activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VAL9", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.4.26.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.26.1", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "5.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.5", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0045931 positive regulation of mitotic cell cycle;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P20483-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1Z9N0-1", "uniprot_id": [ { "id": "A1Z9N0_DROME", "url": "https://www.uniprot.org/uniprot/A1Z9N0", "type": "external" } ], "mass": 111795.0, "length": 972, "protein_name": "Dynamin-like GTPase OPA1, mitochondrial", "gene_name": "Opa1", "organism": "Fruit fly", "refseq_name": "optic atrophy 1, isoform A", "refseq_ac": [ { "id": "NP_725369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_725369", "type": "external" } ], "gene_names_uniprotkb": "Opa1; CG8479; Dmel\\CG8479; Dmel_CG8479; OPA1-like; OPA1; Opa1-like; dOPA1; dOpa1; dOpa; l(2)s3475; opa1-like; opa1", "gene_names_refseq": "CG8479; Dmel\\CG8479; OPA1-like; OPA1; Opa1-like; Opa1; dOPA1; dOpa1; dOpa; l(2)s3475; opa1-like; opa1", "protein_names_uniprotkb": "Dynamin-like GTPase OPA1, mitochondrial; 3.6.5.5", "protein_names_refseq": "CG8479-PA; Opa1-PA; Opa1-like; dOpa1; drosophila optic atrophy 1-like; lethal (2) s3475; optic atrophy 1 ortholog; optic atrophy 1, isoform A", "tax_id": 7227, "disease": "mitochondrial DNA depletion syndrome 14 (Disease Ontology:DOID:0080336); dominant optic atrophy plus syndrome (Disease Ontology:DOID:0111340); optic atrophy 1 (Disease Ontology:DOID:0111441); Behr syndrome (Disease Ontology:DOID:0111580); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); hypertension (Disease Ontology:DOID:10763); transient cerebral ischemia (Disease Ontology:DOID:224); rhinitis (Disease Ontology:DOID:4483); schizophrenia (Disease Ontology:DOID:5419); optic atrophy (Disease Ontology:DOID:5723); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); chronic kidney disease (Disease Ontology:DOID:784); mitochondrial encephalomyopathy (Disease Ontology:DOID:890); ocular hypertension (Disease Ontology:DOID:9282); steatotic liver disease (Disease Ontology:DOID:9452)", "pathway": " (dme:Dmel_CG8479)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008289 lipid binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0010636 positive regulation of mitochondrial fusion;GO:0006915 apoptotic process;GO:0007005 mitochondrion organization;GO:0008053 mitochondrial fusion;GO:0001745 compound eye morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A1Z9N0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35004-1", "uniprot_id": [ { "id": "TRYB_DROME", "url": "https://www.uniprot.org/uniprot/P35004", "type": "external" } ], "mass": 25693.0, "length": 253, "protein_name": "Trypsin beta", "gene_name": "betaTry", "organism": "Fruit fly", "refseq_name": "betaTrypsin, isoform B", "refseq_ac": [ { "id": "NP_001286314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286314", "type": "external" } ], "gene_names_uniprotkb": "betaTry; BetaTry; CG18211; DmBetaTry; Dmel\\CG18211; Dmel_CG18211; SP119; Try; beta", "gene_names_refseq": "BetaTry; CG18211; DmBetaTry; Dmel\\CG18211; SP119; Try; betaTry; beta", "protein_names_uniprotkb": "Trypsin beta; 3.4.21.4", "protein_names_refseq": "CG18211-PB; betaTry-PB; betaTrypsin, isoform B", "tax_id": 7227, "disease": "amelogenesis imperfecta type 2A1 (Disease Ontology:DOID:0110057); prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394)", "pathway": " (dme:Dmel_CG18211)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10486967;10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V5Y3", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0017171 serine hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P35004-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47948-1", "uniprot_id": [ { "id": "TNNC2_DROME", "url": "https://www.uniprot.org/uniprot/P47948", "type": "external" } ], "mass": 17883.0, "length": 155, "protein_name": "Troponin C, isoform 2", "gene_name": "TpnC47D", "organism": "Fruit fly", "refseq_name": "troponin C at 47D, isoform B", "refseq_ac": [ { "id": "NP_001286310", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286310", "type": "external" } ], "gene_names_uniprotkb": "TpnC47D; BcDNA:RE34610; CG9073; DmTnC2; DmTpnC47D; DmTpnCIb; Dmel\\CG9073; Dmel_CG9073; TNC47D; TNC; TPnC47D; TnC47D; TnC; Tnc3; TpnC Ib; TpnCIb", "gene_names_refseq": "BcDNA:RE34610; CG9073; DmTnC2; DmTpnC47D; DmTpnCIb; Dmel\\CG9073; TNC47D; TNC; TPnC47D; TnC47D; TnC; Tnc3; TpnC Ib; TpnC47D; TpnCIb", "protein_names_uniprotkb": "Troponin C, isoform 2", "protein_names_refseq": "CG9073-PB; TpnC47D-PB; troponin C at 47D, isoform B; troponin C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9073); (R-DME-111932); (R-DME-111933); (R-DME-111957); (R-DME-114608); (R-DME-1474151); (R-DME-163615); (R-DME-1855204); (R-DME-2025928); (R-DME-203615); (R-DME-2514859); (R-DME-2871809); (R-DME-4086398); (R-DME-418359); (R-DME-425561); (R-DME-438066); (R-DME-442729); (R-DME-451308); (R-DME-5218920); (R-DME-5578775); (R-DME-5607763); (R-DME-5673000); (R-DME-70221); (R-DME-8876725); (R-DME-9009391); (R-DME-936837); (R-DME-9619229); (R-DME-9648002); (R-DME-9856530)", "pathway_count": 29, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;7980384", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8E6H7;Q8IGT2;Q9V5V9", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P47948-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8DYE2-1", "uniprot_id": [ { "id": "TRPCG_DROME", "url": "https://www.uniprot.org/uniprot/A8DYE2", "type": "external" } ], "mass": 225538.0, "length": 2023, "protein_name": "Transient receptor potential cation channel trpm", "gene_name": "Trpm", "organism": "Fruit fly", "refseq_name": "transient receptor potential cation channel, subfamily M, isoform B", "refseq_ac": [ { "id": "NP_001036548", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036548", "type": "external" } ], "gene_names_uniprotkb": "Trpm; BcDNA:GH04950; CG16805; CG30078; CG30079; CG34123; CG34187; CG44240; DmTRPM; Dmel\\CG44240; Dmel_CG44240; TRPM; TrpM; dTRPM; mdcds_11815; trpm", "gene_names_refseq": "BcDNA:GH04950; CG16805; CG30078; CG30079; CG34123; CG34187; CG44240; DmTRPM; Dmel\\CG44240; TRPM; TrpM; Trpm; dTRPM; mdcds_11815; trpm", "protein_names_uniprotkb": "Transient receptor potential cation channel trpm; Transient receptor potential cation channel, subfamily M ortholog", "protein_names_refseq": "CG44240-PB; Trpm-PB; transient receptor potential cation channel, subfamily M ortholog; transient receptor potential cation channel, subfamily M, isoform B; transient receptor potential channel M", "tax_id": 7227, "disease": "congenital stationary night blindness (Disease Ontology:DOID:0050534); sinoatrial node disease (Disease Ontology:DOID:0050824); MASA syndrome (Disease Ontology:DOID:0060246); chromosome 15q13.3 microdeletion syndrome (Disease Ontology:DOID:0060394); intestinal hypomagnesemia 1 (Disease Ontology:DOID:0060883); congenital stationary night blindness 1C (Disease Ontology:DOID:0110867); amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (Disease Ontology:DOID:0111246); microphthalmia (Disease Ontology:DOID:10629); cataract (Disease Ontology:DOID:83); metal metabolism disorder (Disease Ontology:DOID:896)", "pathway": " (dme:Dmel_CG44240); (R-DME-3295583)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17018572;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Calcium channel mediating constitutive calcium ion entry., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A1Z9Z5;Q0E967;Q7K1C1", "ec_number_list": [], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0005261 monoatomic cation channel activity;GO:0097682 intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0051262 protein tetramerization;GO:0098655 monoatomic cation transmembrane transport;GO:0010960 magnesium ion homeostasis;GO:0006882 intracellular zinc ion homeostasis;GO:0030001 metal ion transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "A8DYE2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8DYH2-1", "uniprot_id": [ { "id": "UFM1_DROME", "url": "https://www.uniprot.org/uniprot/A8DYH2", "type": "external" } ], "mass": 9438.0, "length": 87, "protein_name": "Ubiquitin-fold modifier 1", "gene_name": "Ufm1", "organism": "Fruit fly", "refseq_name": "Ubiquitin-fold modifier 1, isoform A", "refseq_ac": [ { "id": "NP_001097354", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097354", "type": "external" } ], "gene_names_uniprotkb": "Ufm1; CG34191; Dmel\\CG34191; Dmel_CG34191; UFM1; dUFM1", "gene_names_refseq": "CG34191; Dmel\\CG34191; UFM1; Ufm1; dUFM1", "protein_names_uniprotkb": "Ubiquitin-fold modifier 1", "protein_names_refseq": "CG34191-PA; Ubiquitin-fold modifier 1, isoform A; Ufm1-PA", "tax_id": 7227, "disease": "autosomal recessive cerebellar ataxia (Disease Ontology:DOID:0050950); hypomyelinating leukodystrophy 14 (Disease Ontology:DOID:0080296)", "pathway": " (dme:Dmel_CG34191)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;26872069;37086384", "class_list": "", "function": "Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer (By similarity). The so-called ufmylation, requires the UFM1-activating E1 enzyme Uba5, the UFM1-conjugating E2 enzyme Ufc1, and the UFM1-ligase E3 enzyme Ufl1 (By similarity). This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes (By similarity). The Ufm1 cascade might play a role in the development of the neuromuscular junctions (PubMed:26872069)., [UniProtKB, UniProtKB, PubMed]; Ubiquitin-like modifier., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C9QNX3", "ec_number_list": [], "go_molecular_function": "GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0050905 neuromuscular process;GO:0034976 response to endoplasmic reticulum stress;GO:0071569 protein ufmylation;GO:0061709 reticulophagy", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "A8DYH2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1ZBH7-1", "uniprot_id": [ { "id": "A1ZBH7_DROME", "url": "https://www.uniprot.org/uniprot/A1ZBH7", "type": "external" } ], "mass": 132396.0, "length": 1218, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "hppy", "organism": "Fruit fly", "refseq_name": "happyhour, isoform A", "refseq_ac": [ { "id": "NP_725863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_725863", "type": "external" } ], "gene_names_uniprotkb": "hppy; CG7097; Dmel\\CG7097; Dmel_CG7097; EP-704; Hppy; KHS1; MAP4K3; anon-WO0153538.68; hppy; l(2)SH1261; l(2)SH2 1261", "gene_names_refseq": "CG7097/hppy; CG7097; Dmel\\CG7097; EP-704; GLK/KHS1; Hppy; MAP4K3; anon-WO0153538.68; hppy; l(2)SH1261; l(2)SH2 1261", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "CG7097-PA; gene 2; happy hour; happyhour, isoform A; happyhour; hppy-PA; lethal (2) SH1261", "tax_id": 7227, "disease": "ciliopathy (Disease Ontology:DOID:0060340); alcohol use disorder (Disease Ontology:DOID:1574); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (dme:Dmel_CG7097)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008349 MAP kinase kinase kinase kinase activity;GO:0106310 protein serine kinase activity;GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006915 apoptotic process;GO:0007254 JNK cascade;GO:0070328 triglyceride homeostasis;GO:0007030 Golgi organization;GO:0040009 regulation of growth rate", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A1ZBH7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06943-1", "uniprot_id": [ { "id": "HMGZ_DROME", "url": "https://www.uniprot.org/uniprot/Q06943", "type": "external" } ], "mass": 12656.0, "length": 111, "protein_name": "High mobility group protein Z", "gene_name": "HmgZ", "organism": "Fruit fly", "refseq_name": "HMG protein Z, isoform C", "refseq_ac": [ { "id": "NP_001286694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286694", "type": "external" } ], "gene_names_uniprotkb": "HmgZ; BcDNA:RE28596; CG17921; Dmel\\CG17921; Dmel_CG17921; HMG Z; HMG-Z; HMG1; HMGZ; anon-EST:Liang-1.58; clone 1.58; dHMG-Z; hmg-Z; hmgz", "gene_names_refseq": "BcDNA:RE28596; CG17921; Dmel\\CG17921; HMG Z; HMG-Z; HMG1; HMGZ; HmgZ; anon-EST:Liang-1.58; clone 1.58; dHMG-Z; hmg-Z; hmgz", "protein_names_uniprotkb": "High mobility group protein Z; HMG-Z", "protein_names_refseq": "CG17921-PC; HMG protein Z, isoform C; HmgZ-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17921); (R-DME-140342); (R-DME-163282); (R-DME-9837999)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;8414994", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0E8Z4;Q9W2D4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q06943-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10627-1", "uniprot_id": [ { "id": "TWIST_DROME", "url": "https://www.uniprot.org/uniprot/P10627", "type": "external" } ], "mass": 54422.0, "length": 490, "protein_name": "Protein twist", "gene_name": "twi", "organism": "Fruit fly", "refseq_name": "twist, isoform B", "refseq_ac": [ { "id": "NP_001033967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033967", "type": "external" } ], "gene_names_uniprotkb": "twi; CG2956; DTwist; Dmel\\CG2956; Dmel_CG2956; EC9; TWI; Twist; Twi; Tw; bHLHb17; dip5", "gene_names_refseq": "CG2956; DTwist; Dmel\\CG2956; EC9; TWI; Twist; Twi; Tw; bHLHb17; dip5; twi", "protein_names_uniprotkb": "Protein twist", "protein_names_refseq": "CG2956-PB; twi-PB; twist, isoform B; twist", "tax_id": 7227, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); Barber-Say syndrome (Disease Ontology:DOID:0060549); ablepharon macrostomia syndrome (Disease Ontology:DOID:0060550); craniosynostosis 1 (Disease Ontology:DOID:0061010); Sweeney-Cox syndrome (Disease Ontology:DOID:0080538); acrocephalosyndactylia (Disease Ontology:DOID:12960); Saethre-Chotzen syndrome (Disease Ontology:DOID:14768); breast cancer (Disease Ontology:DOID:1612); breast carcinoma (Disease Ontology:DOID:3459); pulmonary fibrosis (Disease Ontology:DOID:3770); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (dme:Dmel_CG2956); (R-DME-9764725)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;1765010;18327897;22396663;25589440;26109356;26109357;3416836", "class_list": "", "function": "Involved in the establishment and dorsoventral patterning of germ layers in the embryo., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LZ34;Q8MT07;Q8T8Y9;Q9W1W1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0016202 regulation of striated muscle tissue development;GO:0007501 mesodermal cell fate specification;GO:0001710 mesodermal cell fate commitment;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P10627-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21519-1", "uniprot_id": [ { "id": "MAM_DROME", "url": "https://www.uniprot.org/uniprot/P21519", "type": "external" } ], "mass": 167261.0, "length": 1594, "protein_name": "Neurogenic protein mastermind", "gene_name": "mam", "organism": "Fruit fly", "refseq_name": "mastermind, isoform D", "refseq_ac": [ { "id": "NP_001286401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286401", "type": "external" } ], "gene_names_uniprotkb": "mam; CG8118; DMam; Dm0064; Dmel\\CG8118; Dmel_CG8118; MAM; MamH; Mam; N-2G; SR2-4; dMam; l(2)03505; l(2)04615; mam(CAG)[[7]]", "gene_names_refseq": "CG8118; DMam; Dm0064; Dmel\\CG8118; MAM; MamH; Mam; N-2G; SR2-4; dMam; l(2)03505; l(2)04615; mam(CAG)[[7]]; mam", "protein_names_uniprotkb": "Neurogenic protein mastermind", "protein_names_refseq": "CG8118-PD; mam-PD; master mind; mastermind, isoform D; mastermind", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8118)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;16508010;1701150;17569856;17569867;25589440;26109356;26109357;8913756", "class_list": "", "function": "Involved in regulation of wing margin enhancer activity; cooperates with Chi and sd to regulate cut expression in the wing margin (PubMed:8913756). May have a regulatory function possibly in association with the Notch gene product., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B5RJ79;Q0E983;Q494M5;Q7KR72;Q8SZU8;Q9V6W7;Q9V6W8", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0000775 chromosome, centromeric region;GO:0000785 chromatin;GO:0005700 polytene chromosome", "go_biological_process": "GO:0046331 lateral inhibition;GO:0007418 ventral midline development;GO:0007219 Notch signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P21519-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53777-1", "uniprot_id": [ { "id": "MLP1_DROME", "url": "https://www.uniprot.org/uniprot/P53777", "type": "external" } ], "mass": 9958.0, "length": 92, "protein_name": "Muscle LIM protein 1", "gene_name": "Mlp60A", "organism": "Fruit fly", "refseq_name": "muscle LIM protein at 60A, isoform F", "refseq_ac": [ { "id": "NP_001286820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286820", "type": "external" } ], "gene_names_uniprotkb": "Mlp60A; BcDNA:RE14544; BcDNA:RH74176; CG30174; CG30179; CG3220; CG33149; CG42309; DLim-2; DMLP1; DMlp1; DmLIM-2; Dmel\\CG42309; Dmel_CG42309; FBgn0259209; LIM2; MLIM 60A; MLP1; MLP60A; MLP; Mlp1; Mlp60; dMlp60A", "gene_names_refseq": "BcDNA:RE14544; BcDNA:RH74176; CG30174; CG30179; CG3220; CG33149; CG42309; DLim-2; DMLP1; DMlp1; DmLIM-2; Dmel\\CG42309; FBgn0259209; MLIM 60A; MLP1; MLP60A; MLP; Mlp1; Mlp60A; Mlp60; dMlp60A", "protein_names_uniprotkb": "Muscle LIM protein 1", "protein_names_refseq": "CG42309-PF; Mlp60A-PF; Muscle-specific LIM protein at 60A; muscle LIM protein 60A; muscle LIM protein at 60A, isoform F", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42309)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;7954791;8794860", "class_list": "", "function": "Positive regulator of myogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1RKS4;Q9W1B4", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0030018 Z disc", "go_biological_process": "GO:0030154 cell differentiation;GO:0007517 muscle organ development;GO:0060537 muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P53777-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6MHQ4-1", "uniprot_id": [ { "id": "NKAIN_DROME", "url": "https://www.uniprot.org/uniprot/A6MHQ4", "type": "external" } ], "mass": 73671.0, "length": 658, "protein_name": "Sodium/potassium-transporting ATPase subunit beta-1-interacting protein", "gene_name": "NKAIN", "organism": "Fruit fly", "refseq_name": "Na,K-ATPase interacting, isoform K", "refseq_ac": [ { "id": "NP_001246506", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246506", "type": "external" } ], "gene_names_uniprotkb": "NKAIN; CG32836; CG34413; CG9047; Dmel\\CG34413; Dmel_CG34413; anon-WO0118547.94; dNKAIN", "gene_names_refseq": "CG32836; CG34413; CG9047; Dmel\\CG34413; NKAIN; anon-WO0118547.94; dNKAIN", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit beta-1-interacting protein; Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein; dNKAIN", "protein_names_refseq": "CG34413-PK; NKAIN-PK; Na,K-ATPase interacting, isoform K", "tax_id": 7227, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); prostate cancer (Disease Ontology:DOID:10283); cognitive disorder (Disease Ontology:DOID:1561); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (dme:Dmel_CG34413)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;17606467;18327897;25589440;26109356;26109357", "class_list": "", "function": "Induces a small but significant sodium conductance when expressed in Xenopus oocytes., [UniProtKB, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "Q8MMC8;Q961Q4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0002028 regulation of sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "A6MHQ4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14083-1", "uniprot_id": [ { "id": "LOV_DROME", "url": "https://www.uniprot.org/uniprot/P14083", "type": "external" } ], "mass": 112308.0, "length": 1046, "protein_name": "Protein jim lovell", "gene_name": "lov", "organism": "Fruit fly", "refseq_name": "jim lovell, isoform D", "refseq_ac": [ { "id": "NP_001014554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014554", "type": "external" } ], "gene_names_uniprotkb": "lov; 091y; 91Y; BTB-III; BtbIII; CG16778; CG2672; Dmel\\CG16778; Dmel_CG16778; Lov; TKR; Tkr; anon-G2; dTKR; g2; tkr", "gene_names_refseq": "091y; 91Y; BTB-III; BtbIII; CG16778; CG2672; Dmel\\CG16778; Lov; TKR; Tkr; anon-G2; dTKR; g2; lov; tkr", "protein_names_uniprotkb": "Protein jim lovell; Protein TKR; Tyrosine kinase-related; dTKR", "protein_names_refseq": "91Y; BTB-protein-III; CG16778-PD; Jim lovell; jim lovell, isoform D; lov-PD; tyrosine kinase related; tyrosine kinase-related protein; tyrosine kinase-related", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG16778)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;11973274;12537568;12537569;12537572;12537573;12537574;16110336;16631157;17569856;17569867;25589440;26109356;26109357;3428600;7938017", "class_list": "", "function": "Has a regulatory role during midline cell development., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A4UZV7;Q0E8V9;Q24002;Q7JPM0;Q7KA34;Q9U1H2;Q9W0W2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0008049 male courtship behavior;GO:0007418 ventral midline development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0048477 oogenesis;GO:0008346 larval walking behavior", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P14083-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54193-1", "uniprot_id": [ { "id": "OB83A_DROME", "url": "https://www.uniprot.org/uniprot/P54193", "type": "external" } ], "mass": 17326.0, "length": 154, "protein_name": "General odorant-binding protein 83a", "gene_name": "Obp83a", "organism": "Fruit fly", "refseq_name": "Odorant-binding protein 83a, isoform B", "refseq_ac": [ { "id": "NP_001287189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287189", "type": "external" } ], "gene_names_uniprotkb": "Obp83a; 83a; CG11421; DmelObp83a; Dmel\\CG11421; Dmel_CG11421; OBP83a; OS-F; Obp33a; Os-F; PB-PRP3; PBP-H2; PBP3; PBPRP-3; PBPRP3; Pbprp3; obp83a; pbprp-3; pbprp3(OS-F); pbprp3", "gene_names_refseq": "83a; CG11421; DmelObp83a; Dmel\\CG11421; OBP83a; OS-F/PBP3; OS-F; Obp33a; Obp83a; Os-F; PB-PRP3; PBP-H2; PBPRP-3; PBPRP3; Pbprp3; obp83a; pbprp-3; pbprp3(OS-F); pbprp3", "protein_names_uniprotkb": "General odorant-binding protein 83a; Odorant-binding protein 83a; Odorant-binding protein OS-F; PBPRP-3; Pheromone-binding protein-related protein 3", "protein_names_refseq": "CG11421-PB; Obp83a-PB; Odorant-binding protein 83a, isoform B; Olfactory-specific-F; Pbprp3; Pheromone-binding protein homolog 2; Pheromone-binding protein-related protein 3", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11421)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;14668382;16110336;17569856;17569867;25589440;26109356;26109357;7545907;8206941;9030621", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q059D8;Q9VNK2", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007608 sensory perception of smell;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P54193-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54611-1", "uniprot_id": [ { "id": "VATE_DROME", "url": "https://www.uniprot.org/uniprot/P54611", "type": "external" } ], "mass": 26082.0, "length": 226, "protein_name": "V-type proton ATPase subunit E", "gene_name": "Vha26", "organism": "Fruit fly", "refseq_name": "vacuolar H[+]-ATPase 26kD subunit, isoform C", "refseq_ac": [ { "id": "NP_001287182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287182", "type": "external" } ], "gene_names_uniprotkb": "Vha26; ATP6V1E1; BcDNA.GH03683; BcDNA:GH03683; CG1088; Dmel\\CG1088; Dmel_CG1088; VhaE; anon-83Bb; chr3R:1419698..1419836; oak-gall; okg; vATPase; vha26", "gene_names_refseq": "ATP6V1E1; BcDNA.GH03683; BcDNA:GH03683; CG1088; Dmel\\CG1088; Vha26; VhaE; anon-83Bb; chr3R:1419698..1419836; oak-gall; okg; vATPase; vha26", "protein_names_uniprotkb": "V-type proton ATPase subunit E; V-ATPase 26 kDa subunit; V-ATPase subunit E; Vacuolar proton pump subunit E", "protein_names_refseq": "CG1088-PC; Vha26-PC; oak gall; vacuolar ATP synthase subunit E; vacuolar H+ATPase subunit E; vacuolar H[+]-ATPase 26 kD E subunit; vacuolar H[+]-ATPase 26kD E subunit; vacuolar H[+]-ATPase 26kD subunit, isoform C", "tax_id": 7227, "disease": "autosomal recessive cutis laxa type IIC (Disease Ontology:DOID:0070140)", "pathway": " (dme:Dmel_CG1088); (R-DME-1222556); (R-DME-77387); (R-DME-917977); (R-DME-9639288); (R-DME-983712)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "10731132;10731138;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8765087", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0KIB6;Q9V3K4", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005886 plasma membrane;GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0033181 plasma membrane proton-transporting V-type ATPase complex;GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain", "go_biological_process": "GO:1902600 proton transmembrane transport;GO:0045176 apical protein localization;GO:0007430 terminal branching, open tracheal system;GO:0035002 liquid clearance, open tracheal system", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P54611-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54351-1", "uniprot_id": [ { "id": "NSF2_DROME", "url": "https://www.uniprot.org/uniprot/P54351", "type": "external" } ], "mass": 83434.0, "length": 752, "protein_name": "Vesicle-fusing ATPase 2", "gene_name": "Nsf2", "organism": "Fruit fly", "refseq_name": "N-ethylmaleimide-sensitive factor 2, isoform B", "refseq_ac": [ { "id": "NP_001287318", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287318", "type": "external" } ], "gene_names_uniprotkb": "Nsf2; CG33101; CG9931; DmNSF2; Dmel\\CG33101; Dmel_CG33101; EC3-11; NSF-2; NSF2; Nsf-2; dNSF-2; dNSF2; dNSF; dNsf2; dnsf2; lotus; urd", "gene_names_refseq": "CG33101; CG9931; DmNSF2; Dmel\\CG33101; EC3-11; NSF-2; NSF2; Nsf-2; Nsf2; dNSF-2; dNSF2; dNSF; dNsf2; dnsf2; lotus; urd", "protein_names_uniprotkb": "Vesicle-fusing ATPase 2; 3.6.4.6; N-ethylmaleimide-sensitive fusion protein 2; NEM-sensitive fusion protein 2; NSF-2; Vesicular-fusion protein NSF2; dNsf-2", "protein_names_refseq": "CG33101-PB; N-ethylmaleimide sensitive factor 2; N-ethylmaleimide-sensitive factor 2, isoform B; NEM-sensitive fusion protein 2; Nsf2-PB; lotus", "tax_id": 7227, "disease": "Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dme:Dmel_CG33101); (R-DME-204005); (R-DME-416993); (R-DME-6807878); (R-DME-6811434); (R-DME-6811438); (R-DME-6811440)", "pathway_count": 7, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;7624376;7642522", "class_list": "", "function": "Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q494J2;Q9VFQ5", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005795 Golgi stack;GO:0098793 presynapse;GO:0045202 synapse", "go_biological_process": "GO:0035494 SNARE complex disassembly;GO:0060439 trachea morphogenesis;GO:0007274 neuromuscular synaptic transmission;GO:0016192 vesicle-mediated transport;GO:0043001 Golgi to plasma membrane protein transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P54351-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0KI28-1", "uniprot_id": [ { "id": "BL1S5_DROME", "url": "https://www.uniprot.org/uniprot/Q0KI28", "type": "external" } ], "mass": 18327.0, "length": 160, "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 5", "gene_name": "Muted", "organism": "Fruit fly", "refseq_name": "muted, isoform A", "refseq_ac": [ { "id": "NP_001036744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036744", "type": "external" } ], "gene_names_uniprotkb": "Muted; CG34131; Dmel\\CG34131; Dmel_CG34131; Dromel_CG7071_FBtr0084211_uORF; NP_001036744; muted", "gene_names_refseq": "CG34131; Dmel\\CG34131; Dromel_CG7071_FBtr0084211_uORF; Muted; NP_001036744; muted", "protein_names_uniprotkb": "Biogenesis of lysosome-related organelles complex 1 subunit 5; BLOC-1 subunit 5; Protein Muted", "protein_names_refseq": "CG34131-PA; CPuORF of FBgn0260467; Muted-PA; muted ortholog; muted, isoform A", "tax_id": 7227, "disease": "platelet storage pool deficiency (Disease Ontology:DOID:2223); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)", "pathway": " (dme:Dmel_CG34131)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;20015953;25589440;26109356;26109357", "class_list": "", "function": "Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030133 transport vesicle;GO:0031083 BLOC-1 complex", "go_biological_process": "GO:0008057 eye pigment granule organization", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q0KI28-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20480-1", "uniprot_id": [ { "id": "NCD_DROME", "url": "https://www.uniprot.org/uniprot/P20480", "type": "external" } ], "mass": 77474.0, "length": 700, "protein_name": "Protein claret segregational", "gene_name": "ncd", "organism": "Fruit fly", "refseq_name": "non-claret disjunctional, isoform B", "refseq_ac": [ { "id": "NP_001287592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287592", "type": "external" } ], "gene_names_uniprotkb": "ncd; CA(ND); CG7831; DmNCD; DmNcd; Dmel\\CG7831; Dmel_CG7831; KIF C1; KIFC1; NCD; Ncd; ca[nd]; ca; cd; l(3)05884; ndc", "gene_names_refseq": "CG7831; DmNCD; DmNcd; Dmel\\CG7831; KIF C1; KIFC1; NCD; Ncd; ca[nd]; ca; cd; l(3)05884; ncd; ndc", "protein_names_uniprotkb": "Protein claret segregational; 3.6.4.-; Kinesin-14", "protein_names_refseq": "CG7831-PB; Kinesin3A; Non-Claret disjunctional; claret nondisjunctional; kinesin-14; ncd-PB; non-claret disjunctional, isoform B; non-claret disjunction; non-claret-disjunctional; nonclaret disjunctional; nonclaret disjunction", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7831)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;1691829;17569856;17569867;1825056;18327897;2140958;2146510;25589440;26109356;26109357;27452403;8112290;8606780;8670831", "class_list": "", "function": "Minus-end-directed microtubule-based motor protein (PubMed:2146510, PubMed:27452403, PubMed:8112290). Has ATPase activity (PubMed:27452403). Required for normal chromosomal segregation in meiosis in females, and in early mitotic divisions of the embryo (PubMed:1691829)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VAG8", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016787 hydrolase activity;GO:0042803 protein homodimerization activity;GO:0008569 minus-end-directed microtubule motor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol;GO:0072687 meiotic spindle", "go_biological_process": "GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0007051 spindle organization;GO:0090306 meiotic spindle assembly", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "P20480-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16911-1", "uniprot_id": [ { "id": "KAPC2_DROME", "url": "https://www.uniprot.org/uniprot/P16911", "type": "external" } ], "mass": 41468.0, "length": 354, "protein_name": "cAMP-dependent protein kinase catalytic subunit 2", "gene_name": "Pka-C2", "organism": "Fruit fly", "refseq_name": "protein kinase, cAMP-dependent, catalytic subunit 2, isoform B", "refseq_ac": [ { "id": "NP_733397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_733397", "type": "external" } ], "gene_names_uniprotkb": "Pka-C2; CG12066; CdkB; DC1a; DC1; Dmel\\CG12066; Dmel_CG12066; PKA C2; PKA-C2; PKAC2; PKA", "gene_names_refseq": "CG12066; CdkB; DC1a; DC1; Dmel\\CG12066; PKA C2; PKA-C2; PKAC2; PKA; Pka-C2", "protein_names_uniprotkb": "cAMP-dependent protein kinase catalytic subunit 2; 2.7.11.1; Protein kinase DC1", "protein_names_refseq": "CG12066-PB; Pka-C2-PB; cAMP-dependent protein kinase 2; cAMP-dependent protein kinase type II; protein kinase, cAMP-dependent, catalytic subunit 2, isoform B", "tax_id": 7227, "disease": "adrenal cortical adenoma (Disease Ontology:DOID:0050891); primary pigmented nodular adrenocortical disease 4 (Disease Ontology:DOID:0070549); platelet-type bleeding disorder 19 (Disease Ontology:DOID:0111048); brain ischemia (Disease Ontology:DOID:2316); fibrolamellar carcinoma (Disease Ontology:DOID:5015); congestive heart failure (Disease Ontology:DOID:6000); amphetamine abuse (Disease Ontology:DOID:670)", "pathway": " (dme:Dmel_CG12066); (R-DME-163615); (R-DME-164378); (R-DME-180024); (R-DME-381676); (R-DME-392517); (R-DME-422356); (R-DME-432040); (R-DME-442720); (R-DME-5610785); (R-DME-5610787); (R-DME-5621575); (R-DME-9634597); (R-DME-983231); (R-DME-9856530)", "pathway_count": 15, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;3215511", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P16910;Q53XD8;Q8IMH7", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004691 cAMP-dependent protein kinase activity;GO:0034237 protein kinase A regulatory subunit binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0031588 nucleotide-activated protein kinase complex;GO:0005952 cAMP-dependent protein kinase complex", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007476 imaginal disc-derived wing morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P16911-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0C4DHF9-1", "uniprot_id": [ { "id": "A0A0C4DHF9_DROME", "url": "https://www.uniprot.org/uniprot/A0A0C4DHF9", "type": "external" } ], "mass": 31655.0, "length": 290, "protein_name": "Entomoglyceroporin 2, isoform C", "gene_name": "Eglp2", "organism": "Fruit fly", "refseq_name": "entomoglyceroporin 2, isoform C", "refseq_ac": [ { "id": "NP_788433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788433", "type": "external" } ], "gene_names_uniprotkb": "Eglp2; Aqp17664; CG17664; Dmel\\CG17664; Dmel_CG17664; Eglp 2", "gene_names_refseq": "Aqp17664; CG17664; Dmel\\CG17664; Eglp 2; Eglp2", "protein_names_uniprotkb": "Entomoglyceroporin 2, isoform C", "protein_names_refseq": "CG17664-PC; Eglp2-PC; entomoglyceroporin 2, isoform C", "tax_id": 7227, "disease": "Alpers-Huttenlocher syndrome (Disease Ontology:DOID:0080122); megalencephalic leukoencephalopathy with subcortical cysts (Disease Ontology:DOID:0080315); transverse myelitis (Disease Ontology:DOID:0080743); nephrogenic diabetes insipidus type 2 (Disease Ontology:DOID:0081061); cataract 15 multiple types (Disease Ontology:DOID:0110251); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); Bothnian type palmoplantar keratoderma (Disease Ontology:DOID:0111707); dry eye syndrome (Disease Ontology:DOID:10140); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hydrocephalus (Disease Ontology:DOID:10908); optic neuritis (Disease Ontology:DOID:1210); primary biliary cholangitis (Disease Ontology:DOID:12236); malaria (Disease Ontology:DOID:12365); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); uveitis (Disease Ontology:DOID:13141); blindness (Disease Ontology:DOID:1432); retinal vein occlusion (Disease Ontology:DOID:1727); status epilepticus (Disease Ontology:DOID:1824); diabetic ketoacidosis (Disease Ontology:DOID:1837); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); thymoma (Disease Ontology:DOID:3275); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); brain edema (Disease Ontology:DOID:4724); retinal disease (Disease Ontology:DOID:5679); central pontine myelinolysis (Disease Ontology:DOID:636); cataract (Disease Ontology:DOID:83); neuromyelitis optica (Disease Ontology:DOID:8869); diabetic retinopathy (Disease Ontology:DOID:8947); cerebral amyloid angiopathy (Disease Ontology:DOID:9246); diabetes mellitus (Disease Ontology:DOID:9351); diabetes insipidus (Disease Ontology:DOID:9409); intracranial hypertension (Disease Ontology:DOID:9428); Meniere's disease (Disease Ontology:DOID:9849)", "pathway": " (dme:Dmel_CG17664); (R-DME-1237044); (R-DME-1247673); (R-DME-432040); (R-DME-432047)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 37, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015267 channel activity;GO:0015250 water channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006833 water transport;GO:0003014 renal system process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A0C4DHF9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B6JUP5-1", "uniprot_id": [ { "id": "VASA2_DROME", "url": "https://www.uniprot.org/uniprot/B6JUP5", "type": "external" } ], "mass": 112515.0, "length": 1031, "protein_name": "Sister chromatid cohesion protein solo", "gene_name": "solo", "organism": "Fruit fly", "refseq_name": "sisters on the loose, isoform A", "refseq_ac": [ { "id": "NP_001027274", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027274", "type": "external" } ], "gene_names_uniprotkb": "solo; BG:DS00929.15; CG33678; CG43081; CG46282; Dmel\\CG46282; Dmel_CG46282; SOLO; Solo; cgt; fs(2)ltoRJ36; pf7", "gene_names_refseq": "BG:DS00929.15; CG33678; CG43081; CG46282; Dmel\\CG46282; SOLO; Solo; cgt; fs(2)ltoRJ36; pf7; solo", "protein_names_uniprotkb": "Sister chromatid cohesion protein solo; Sisters on the loose", "protein_names_refseq": "CG46282-PA; courgette; female sterile(2)ltoRJ36; no-relish; sisters on the loose, isoform A; solo-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG46282)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;18327897;20142422;25589440;26109356;26109357", "class_list": "", "function": "Isoform solo and SMC1 function as partners in mediating sister chromatid and centromere cohesion in meiosis. Not required for sister chromatid arm cohesion or for mitotic chromatid segregation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4ABF3", "ec_number_list": [], "go_molecular_function": "GO:0043221 SMC family protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000775 chromosome, centromeric region", "go_biological_process": "GO:0030154 cell differentiation;GO:0051754 meiotic sister chromatid cohesion, centromeric;GO:0051321 meiotic cell cycle;GO:0034089 establishment of meiotic sister chromatid cohesion;GO:0007143 female meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "B6JUP5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M9MSG8-1", "uniprot_id": [ { "id": "PIEZO_DROME", "url": "https://www.uniprot.org/uniprot/M9MSG8", "type": "external" } ], "mass": 289447.0, "length": 2551, "protein_name": "Piezo-type mechanosensitive ion channel component", "gene_name": "Piezo", "organism": "Fruit fly", "refseq_name": "piezo, isoform I", "refseq_ac": [ { "id": "NP_001188719", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188719", "type": "external" } ], "gene_names_uniprotkb": "Piezo; CG18103; CG31608; CG44122; CG8486; DmPIEZO; DmPiezo; Dmel\\CG44122; Dmel_CG44122; Dmpiezo; OrfKD; anon-EST:Liang-1.32; clone 1.32; fos28F; fos500; piezo", "gene_names_refseq": "CG18103; CG31608; CG44122; CG8486; DmPIEZO; DmPiezo; Dmel\\CG44122; Dmpiezo; OrfKD; Piezo; anon-EST:Liang-1.32; clone 1.32; fos28F; fos500; piezo", "protein_names_uniprotkb": "Piezo-type mechanosensitive ion channel component", "protein_names_refseq": "CG44122-PI; Piezo-PI; dmpiezo; fos-related gene at 28F; piezo, isoform I", "tax_id": 7227, "disease": "hereditary lymphedema (Disease Ontology:DOID:0050580); dehydrated hereditary stomatocytosis (Disease Ontology:DOID:0111575); dehydrated hereditary stomatocytosis 1 (Disease Ontology:DOID:0111576); distal arthrogryposis type 3 (Disease Ontology:DOID:0111607); distal arthrogryposis type 5 (Disease Ontology:DOID:0111608)", "pathway": " (dme:Dmel_CG44122)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;22343891;22343900;25589440;26109356;26109357;32649914", "class_list": "", "function": "Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents (PubMed:22343891, PubMed:22343900). Plays a major role in nociception (response to strong or painful touch) (PubMed:22343891). Required for maintaining the mechanosensitivity of tarsal bristle mechanosensors (PubMed:32649914). During their evalulation of potential egg-laying sites, females determine the softest substrate for their eggs first by making a coarse evaluation of substrate hardness using mechanosensitive channels nan and Piezo in the leg tarsal bristles, followed by a much finer assessment using nan, iav and Tmc mechanosensitive channels on the labellum (PubMed:32649914). Acts in the nompC- and nan-expressing neurons of the female leg tarsals, to sense the mild differences in egg-laying substrate stiffness (PubMed:32649914)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "H6X2P4", "ec_number_list": [], "go_molecular_function": "GO:0005261 monoatomic cation channel activity;GO:0008381 mechanosensitive monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007638 mechanosensory behavior;GO:0042391 regulation of membrane potential;GO:0034220 monoatomic ion transmembrane transport;GO:0050965 detection of temperature stimulus involved in sensory perception of pain;GO:0098655 monoatomic cation transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "M9MSG8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54366-1", "uniprot_id": [ { "id": "GSC_DROME", "url": "https://www.uniprot.org/uniprot/P54366", "type": "external" } ], "mass": 44506.0, "length": 415, "protein_name": "Homeobox protein goosecoid", "gene_name": "Gsc", "organism": "Fruit fly", "refseq_name": "goosecoid, isoform C", "refseq_ac": [ { "id": "NP_476949", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476949", "type": "external" } ], "gene_names_uniprotkb": "Gsc; 60Mun1; 60Mun2; CG2851; D-Gsc; D-gsc; Dmel\\CG2851; Dmel_CG2851; GSC; M72; PPH25; Pph25; gsc; l(2)05341", "gene_names_refseq": "60Mun1; 60Mun2; CG2851; D-Gsc; D-gsc; Dmel\\CG2851; GSC; Gsc; M72; PPH25; Pph25; gsc; l(2)05341", "protein_names_uniprotkb": "Homeobox protein goosecoid", "protein_names_refseq": "CG2851-PC; Gsc-PC; goosecoid, isoform C; goosecoid; muenster 72", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2851)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8625850;8670808", "class_list": "", "function": "Appears to regulate regional development of specific tissues. Can rescue axis polarity in UV-radiated Xenopus embryos., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VPR9", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P54366-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52302-1", "uniprot_id": [ { "id": "MBN_DROME", "url": "https://www.uniprot.org/uniprot/P52302", "type": "external" } ], "mass": 67144.0, "length": 653, "protein_name": "Protein lethal(3)malignant blood neoplasm 1", "gene_name": "l(3)mbn", "organism": "Fruit fly", "refseq_name": "lethal (3) malignant blood neoplasm, isoform B", "refseq_ac": [ { "id": "NP_729143", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_729143", "type": "external" } ], "gene_names_uniprotkb": "l(3)mbn; CG12755; Dmel\\CG12755; Dmel_CG12755; MBN; l(3)malignant blood neoplasm1; l(3)mbn-1; l(3)mbn1", "gene_names_refseq": "CG12755; Dmel\\CG12755; MBN; l(3)malignant blood neoplasm1; l(3)mbn-1; l(3)mbn1; l(3)mbn", "protein_names_uniprotkb": "Protein lethal(3)malignant blood neoplasm 1; Mbn(83)", "protein_names_refseq": "CG12755-PB; l(3)mbn-PB; lethal (3) malignant blood neoplasm, isoform B; lethal(3)malignant blood neoplasm-1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12755)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8174791", "class_list": "", "function": "Required for differentiation of the phagocytic blood-cell type, the plasmatocyte., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q59E19;Q8MS87;Q9VRU6", "ec_number_list": [], "go_molecular_function": "GO:0008010 structural constituent of chitin-based larval cuticle;GO:0042302 structural constituent of cuticle", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0062129 chitin-based extracellular matrix", "go_biological_process": "GO:0040003 chitin-based cuticle development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P52302-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A126GUP6-1", "uniprot_id": [ { "id": "MP1_DROME", "url": "https://www.uniprot.org/uniprot/A0A126GUP6", "type": "external" } ], "mass": 44939.0, "length": 400, "protein_name": "Melanization protease 1", "gene_name": "MP1", "organism": "Fruit fly", "refseq_name": "melanization protease 1, isoform C", "refseq_ac": [ { "id": "NP_001138002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138002", "type": "external" } ], "gene_names_uniprotkb": "MP1; CG1102", "gene_names_refseq": "BEST:GH02921; CG1102; Dmel\\CG1102; MP1; SP25; cSP25; proPO-AE", "protein_names_uniprotkb": "Melanization protease 1; 3.4.21.-", "protein_names_refseq": "CG1102-PC; MP1-PC; melanization protease 1, isoform C; melanization protease 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1102)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;10731138;12537572;16861233;18854145;22227521", "class_list": "", "function": "Serine protease which plays an essential role in the melanization immune response by acting downstream of sp7 to activate prophenoloxidase (PPO1) (PubMed:16861233). May function in diverse Hayan-dependent PPO1-activating cascades that are negatively controlled by different serpin proteins; Spn27A in the hemolymph and Spn77BA in the trachea (PubMed:16861233, PubMed:18854145). Regulation of melanization and PPO1 activation appears to be largely independent of the Toll signaling pathway (PubMed:16861233)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "B7Z0T0;E8NHA1;Q9Y157", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding;GO:0017171 serine hydrolase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0045087 innate immune response;GO:0009620 response to fungus;GO:0035006 melanization defense response;GO:0160032 Toll receptor ligand protein activation cascade", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A0A126GUP6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1W5PW68-1", "uniprot_id": [ { "id": "A0A1W5PW68_DROME", "url": "https://www.uniprot.org/uniprot/A0A1W5PW68", "type": "external" } ], "mass": 5070.0, "length": 42, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG46307", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_001334745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334745", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG46307; CG46307; Dmel_CG46307; Nhe2-5'utr", "gene_names_refseq": "CG46307; Dmel\\CG46307; Nhe2-5'utr", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG46307-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG46307)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A1W5PW68-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1Z1CN75-1", "uniprot_id": [ { "id": "A0A1Z1CN75_DROME", "url": "https://www.uniprot.org/uniprot/A0A1Z1CN75", "type": "external" } ], "mass": 6590.0, "length": 55, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG46312", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_001334683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334683", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG46312; CG46312; Dmel_CG46312; eIF5-5'utr", "gene_names_refseq": "CG46312; Dmel\\CG46312; eIF5-5'utr", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG46312-PA; CPuORF of FBgn0030719; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG46312)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A1Z1CN75-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O61365-1", "uniprot_id": [ { "id": "NACH_DROME", "url": "https://www.uniprot.org/uniprot/O61365", "type": "external" } ], "mass": 62330.0, "length": 535, "protein_name": "Sodium channel protein Nach", "gene_name": "Nach", "organism": "Fruit fly", "refseq_name": "nach, isoform E", "refseq_ac": [ { "id": "NP_001334724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334724", "type": "external" } ], "gene_names_uniprotkb": "Nach; CG8178; Dmel\\CG8178; Dmel_CG8178; PPK4; ppk4", "gene_names_refseq": "CG8178; Dmel\\CG8178; Nach; PPK4; ppk4", "protein_names_uniprotkb": "Sodium channel protein Nach; Pickpocket protein 4", "protein_names_refseq": "CG8178-PE; Nach-PE; nach, isoform E; pickpocket 4", "tax_id": 7227, "disease": "Liddle syndrome (Disease Ontology:DOID:0050477); autosomal recessive pseudohypoaldosteronism type 1 (Disease Ontology:DOID:0060854); bronchiectasis 1 (Disease Ontology:DOID:0080526); nephrotic syndrome (Disease Ontology:DOID:1184); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); cystic fibrosis (Disease Ontology:DOID:1485); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); pseudohypoaldosteronism (Disease Ontology:DOID:4479)", "pathway": " (dme:Dmel_CG8178)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;12571352;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Part of a complex that plays a role in tracheal liquid clearance. Probable role in sodium transport., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q7KRC7;Q86LH4;Q9V7S4", "ec_number_list": [], "go_molecular_function": "GO:0005272 sodium channel activity;GO:0015081 sodium ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0009992 intracellular water homeostasis;GO:0035725 sodium ion transmembrane transport;GO:0006814 sodium ion transport;GO:0036335 intestinal stem cell homeostasis;GO:0035002 liquid clearance, open tracheal system", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O61365-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A384SYE0-1", "uniprot_id": [ { "id": "A0A384SYE0_DROME", "url": "https://www.uniprot.org/uniprot/A0A384SYE0", "type": "external" } ], "mass": 3186.0, "length": 30, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG44388", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_001334725", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334725", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG44388; CG44388; CR44388; Dmel_CG44388; FBgn0265538; lincRNA.332", "gene_names_refseq": "CG44388; CR44388; Dmel\\CG44388; FBgn0265538; lincRNA.332", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG44388-PB; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG44388)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A0A384SYE0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24117-1", "uniprot_id": [ { "id": "DYL1_DROME", "url": "https://www.uniprot.org/uniprot/Q24117", "type": "external" } ], "mass": 10374.0, "length": 89, "protein_name": "Dynein light chain 1, cytoplasmic", "gene_name": "ctp", "organism": "Fruit fly", "refseq_name": "cut up, isoform E", "refseq_ac": [ { "id": "NP_001245530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245530", "type": "external" } ], "gene_names_uniprotkb": "ctp; CG6998; Cdlc1; Ctp; DLC8; DdlC1; Ddlc-1; Ddlc1; Dlc; Dmel\\CG6998; Dmel_CG6998; LC8; anon-WO03040301.128; dDYNLL1; ddlc1; dlc; l(1)G0153; l(1)G0204; l(1)G0207; l(1)G0244; l(1)G0248; l(1)G0338; l(1)G0371; l(1)G0387; l(1)G0432; l(1)G0445; lincRNA.S8635", "gene_names_refseq": "CG6998; Cdlc1; Ctp; DLC8; DdlC1; Ddlc-1; Ddlc1; Dlc; Dmel\\CG6998; LC8; anon-WO03040301.128; ctp; dDYNLL1; ddlc1; dlc; l(1)G0153; l(1)G0204; l(1)G0207; l(1)G0244; l(1)G0248; l(1)G0338; l(1)G0371; l(1)G0387; l(1)G0432; l(1)G0445; lincRNA.S8635", "protein_names_uniprotkb": "Dynein light chain 1, cytoplasmic; 8 kDa dynein light chain; Cut up protein", "protein_names_refseq": "8kd dynein light chain; CG6998-PE; Cut up; ctp-PE; cut up, isoform E; cytoplasmic dynein 8kD light chain; cytoplasmic dynein light chain 1; dynein light chain 1; dynein light chain 8; dynein light chain LC8; dynein light-chain 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6998); (R-DME-1632852); (R-DME-3371497); (R-DME-6798695); (R-DME-6807878); (R-DME-6811436); (R-DME-9646399)", "pathway_count": 7, "publication_count": 16, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;16540510;17569856;17569867;18465876;25589440;26092846;26109356;26109357;26540204;8628263", "class_list": "", "function": "Acts as a non-catalytic accessory component of a dynein complex., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V3Y5;Q9V3Y6", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005198 structural molecule activity;GO:0097718 disordered domain specific binding;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005814 centriole", "go_biological_process": "GO:0007283 spermatogenesis;GO:0051017 actin filament bundle assembly;GO:0000132 establishment of mitotic spindle orientation;GO:0048477 oogenesis;GO:0007291 sperm individualization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q24117-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07152-1", "uniprot_id": [ { "id": "IMDH_DROME", "url": "https://www.uniprot.org/uniprot/Q07152", "type": "external" } ], "mass": 57829.0, "length": 537, "protein_name": "Inosine-5'-monophosphate dehydrogenase", "gene_name": "ras", "organism": "Fruit fly", "refseq_name": "raspberry, isoform D", "refseq_ac": [ { "id": "NP_001259427", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259427", "type": "external" } ], "gene_names_uniprotkb": "ras; CG11485; CG1799; Dmel\\CG1799; Dmel_CG1799; EP(X)1093; IMPDH; IMPdH; LD02673; LD06825; Ras; impd; l(1)9Eb; l(1)G0002; l(1)G0056; l(1)G0098; l(1)G0127; l(1)G0238; l(1)G0351; l(1)G0380; l(1)G0388; l(1)G0391; l(1)G0436; l(1)G0482; ras-l", "gene_names_refseq": "CG11485; CG1799; Dmel\\CG1799; EP(X)1093; IMPDH; IMPdH; LD02673; LD06825; Ras; l(1)9Eb; l(1)G0002; l(1)G0056; l(1)G0098; l(1)G0127; l(1)G0238; l(1)G0351; l(1)G0380; l(1)G0388; l(1)G0391; l(1)G0436; l(1)G0482; ras-l; raspberry/impd; ras", "protein_names_uniprotkb": "Inosine-5'-monophosphate dehydrogenase; 1.1.1.205; IMP dehydrogenase; IMPDH; IMPD; Protein raspberry", "protein_names_refseq": "CG1799-PD; IMP dehydrogenase; inosine monophosphate dehydrogenase; lethal (1) G0380; ras-PD; raspberry, isoform D; raspberry-lethal", "tax_id": 7227, "disease": "Leber congenital amaurosis 11 (Disease Ontology:DOID:0110216); retinitis pigmentosa 10 (Disease Ontology:DOID:0110388); retinitis pigmentosa (Disease Ontology:DOID:10584)", "pathway": " (dme:Dmel_CG1799); (R-DME-6798695); (R-DME-73817); (R-DME-9748787)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;7476879;7904480;7911114", "class_list": "", "function": "Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth., [UniProtKB, HAMAP, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, 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"https://www.rhea-db.org/rhea/?query=ec:3.5.2.17", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": 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The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C6SUU7;H1UU98", "ec_number_list": [], "go_molecular_function": "GO:0003743 translation initiation factor activity;GO:0031369 translation initiation factor binding;GO:0140492 metal-dependent deubiquitinase activity", "go_cellular_component": "GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m;GO:0005852 eukaryotic translation initiation factor 3 complex", "go_biological_process": "GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A1Z6K7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1Z6L1-1", "uniprot_id": [ { "id": "TO402_DROME", "url": "https://www.uniprot.org/uniprot/A1Z6L1", "type": "external" } ], "mass": 36983.0, "length": 340, "protein_name": "Mitochondrial import receptor subunit TOM40 homolog 2", "gene_name": "tomboy40", "organism": "Fruit fly", "refseq_name": "tomboy40", "refseq_ac": [ { "id": "NP_610213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610213", "type": "external" } ], "gene_names_uniprotkb": "tomboy40; CG8330", "gene_names_refseq": "CG8330; Dmel\\CG8330; Tomboy40; tomboy40", "protein_names_uniprotkb": "Mitochondrial import receptor subunit TOM40 homolog 2; Translocase of outer membrane 40 kDa subunit homolog 2", "protein_names_refseq": "CG8330-PA; dtomboy40; tomboy40-PA; tomboy40", "tax_id": 7227, "disease": "cerebral infarction (Disease Ontology:DOID:3526)", "pathway": " (dme:Dmel_CG8330)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;15304338", "class_list": "", "function": "Channel-forming protein essential for import of protein precursors into mitochondria., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NN68", "ec_number_list": [], "go_molecular_function": "GO:0015288 porin activity;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0046930 pore complex;GO:0005742 mitochondrial outer membrane translocase complex", "go_biological_process": "GO:0045040 protein insertion into mitochondrial outer membrane;GO:0006811 monoatomic ion transport;GO:0006626 protein targeting to mitochondrion;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A1Z6L1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1Z713-1", "uniprot_id": [ { "id": "VPS13_DROME", "url": "https://www.uniprot.org/uniprot/A1Z713", "type": "external" } ], "mass": 374545.0, "length": 3321, "protein_name": "Intermembrane lipid transfer protein Vps13", "gene_name": "Vps13", "organism": "Fruit fly", "refseq_name": "vacuolar protein sorting 13, isoform B", "refseq_ac": [ { "id": "NP_001260781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260781", "type": "external" } ], "gene_names_uniprotkb": "Vps13; 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Plays a role in the survival of neurons by maintaining protein homeostasis in the central nervous system (PubMed:28107480). May function as part of a lysosomal degradation pathway (PubMed:28107480)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031902 late endosome membrane", "go_biological_process": "GO:0045053 protein retention in Golgi apparatus;GO:0006869 lipid transport;GO:0006623 protein targeting to vacuole", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A1Z713-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1Z784-1", "uniprot_id": [ { "id": "A1Z784_DROME", "url": "https://www.uniprot.org/uniprot/A1Z784", "type": "external" } ], "mass": 278596.0, "length": 2482, "protein_name": "6.-.-.-; 6.3.4.14; 6.4.1.2; Acetyl-CoA carboxylase, isoform A", "gene_name": "Acc", "organism": "Fruit fly", "refseq_name": "Acetyl-CoA carboxylase, isoform A", "refseq_ac": [ { "id": "NP_610342", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610342", "type": "external" } ], "gene_names_uniprotkb": "Acc; A1Z784_DROME; ACC; ACoT; CG11198; CG8723; DmACC; Dmel\\CG11198; Dmel_CG11198; FBgn0043811; acc; dACC", "gene_names_refseq": "A1Z784_DROME; ACC; ACoT; Acc; CG11198; CG8723; DmACC; Dmel\\CG11198; FBgn0043811; acc; dACC", "protein_names_uniprotkb": "6.-.-.-; 6.3.4.14; 6.4.1.2; Acetyl-CoA carboxylase, isoform A", "protein_names_refseq": "ACC-PA; Acetyl-CoA carboxylase, isoform A; CG11198-PA; aceto-acetyl-CoA-thiolase; acetyl CoA carboxylase; acetyl coenzyme A carboxylase; acetyl-CoA carboxylase; acetyl-CoA-carboxylase; acetyl-coenzyme A carboxylase; acyl-coA carboxylase", "tax_id": 7227, "disease": "chromosome 17q12 deletion syndrome (Disease Ontology:DOID:0060404); muscular disease (Disease Ontology:DOID:0080000); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (R-DME-196780); (R-DME-200425); (R-DME-75105)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.-", "type": "external" }, { "id": "6.3.4.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.15", "type": "external" }, { "id": "6.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.-.-.-", "type": "external" }, { "id": "6.3.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.14", "type": "external" }, { "id": "6.4.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003989 acetyl-CoA carboxylase activity;GO:0004075 biotin carboxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006084 acetyl-CoA metabolic process;GO:0006633 fatty acid biosynthetic process;GO:2001295 malonyl-CoA biosynthetic process;GO:0009744 response to sucrose;GO:0019432 triglyceride biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A1Z784-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1Z7I6-1", "uniprot_id": [ { "id": "A1Z7I6_DROME", "url": "https://www.uniprot.org/uniprot/A1Z7I6", "type": "external" } ], "mass": 17187.0, "length": 149, "protein_name": "HMG box domain-containing protein", "gene_name": "Dmel\\CG30356", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_724709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724709", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG30356; CG30356; Dmel_CG30356", "gene_names_refseq": "CG30356; Dmel\\CG30356", "protein_names_uniprotkb": "HMG box domain-containing protein", "protein_names_refseq": "CG30356-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG30356)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A1Z7I6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1Z7U8-1", "uniprot_id": [ { "id": "A1Z7U8_DROME", "url": "https://www.uniprot.org/uniprot/A1Z7U8", "type": "external" } ], "mass": 21216.0, "length": 178, "protein_name": "MD-2-related lipid-recognition domain-containing protein", "gene_name": "Dmel\\CG33757", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_001027398", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027398", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG33757; 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BACR48G21.1; BG:BACR48G21.1; CG30340; Dmel_CG30340", "gene_names_refseq": "BACR48G21.1; BG:BACR48G21.1; CG30340; Dmel\\CG30340", "protein_names_uniprotkb": "G-protein coupled receptors family 1 profile domain-containing protein", "protein_names_refseq": "CG30340-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG30340)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008188 neuropeptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A1Z7X3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1JH25-1", "uniprot_id": [ { "id": "TEA_DROME", "url": "https://www.uniprot.org/uniprot/E1JH25", "type": "external" } ], "mass": 211809.0, "length": 1876, "protein_name": "Protein telomere ends associated", "gene_name": "tea", "organism": "Fruit fly", "refseq_name": "telomere ends associated, isoform D", "refseq_ac": [ { "id": "NP_001163106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163106", "type": "external" } ], "gene_names_uniprotkb": "tea; CG12138; CG30007; Dmel\\CG30007; Dmel_CG30007; III; TEA; Tea; l(2)46Cc; l(2)SH0071; l(2)SH2 0071", "gene_names_refseq": "CG12138; CG30007; Dmel\\CG30007; III; TEA; Tea; l(2)46Cc; l(2)SH0071; l(2)SH2 0071; tea", "protein_names_uniprotkb": "Protein telomere ends associated", "protein_names_refseq": "CG30007-PD; group III; lethal (2) 46Cc; lethal (2) SH0071; tea-PD; telomere ends Associated, D; telomere ends associated, isoform D", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG30007)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;27835648", "class_list": "", "function": "Part of the MTV complex that associates with the HipHop-HOAP complex to form the terminin telomere-capping complex involved in telomere maintenance and prevention of telomere fusion (PubMed:27835648). As part of the MTV complex binds single stranded DNA in a sequence-independent manner, protecting it from degradation (PubMed:27835648). May mediate recruitment of the MTV complex at telomeres through interaction with components of the HipHop-HOAP complex (PubMed:27835648)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1Z817", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000781 chromosome, telomeric region;GO:0000782 telomere cap complex", "go_biological_process": "GO:0031848 protection from non-homologous end joining at telomere;GO:0016233 telomere capping", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "E1JH25-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1Z8R8-1", "uniprot_id": [ { "id": "PARL_DROME", "url": "https://www.uniprot.org/uniprot/A1Z8R8", "type": "external" } ], "mass": 38932.0, "length": 351, "protein_name": "Presenilins-associated rhomboid-like protein, mitochondrial", "gene_name": "rho-7", "organism": "Fruit fly", "refseq_name": "rhomboid-7, isoform B", "refseq_ac": [ { "id": "NP_001286324", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286324", "type": "external" } ], "gene_names_uniprotkb": "rho-7; CG8972; Parl; R7", "gene_names_refseq": "CG8972; Dmel\\CG8972; PARL; R7; Rho-7; Rhomboid-7; anon-WO0138581.3; rho-7", "protein_names_uniprotkb": "Presenilins-associated rhomboid-like protein, mitochondrial; 3.4.21.105; Mitochondrial intramembrane-cleaving protease Parl; Rhomboid-7", "protein_names_refseq": "CG8972-PB; Rhomboid-7; rho-7-PB; rhomboid-7, isoform B", "tax_id": 7227, "disease": "myopia (Disease Ontology:DOID:11830); hyperinsulinism (Disease Ontology:DOID:2018); coronary artery disease (Disease Ontology:DOID:3393); breast carcinoma (Disease Ontology:DOID:3459); Leigh disease (Disease Ontology:DOID:3652); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dme:Dmel_CG8972)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;16713954;19048081;21945938", "class_list": "", "function": "Mitochondrial intramembrane protease which plays a critical role in the regulation of mitochondrial function (PubMed:16713954, PubMed:21945938). Essential for mitochondrial development and fusion during spermatogenesis and the development of neurons and muscles (PubMed:16713954, PubMed:21945938). Essential for proteolytic processing of Pink1 and HtrA2 into their mature forms (PubMed:19048081). May also be involved, but not required, for the proteolytic processing of Opa1 (PubMed:19048081, PubMed:21945938)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MQY3", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0016485 protein processing;GO:0008053 mitochondrial fusion;GO:1903214 regulation of protein targeting to mitochondrion;GO:0010821 regulation of mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A1Z8R8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1Z9I6-1", "uniprot_id": [ { "id": "A1Z9I6_DROME", "url": "https://www.uniprot.org/uniprot/A1Z9I6", "type": "external" } ], "mass": 42171.0, "length": 374, "protein_name": "E3 ubiquitin-protein ligase RNF25", "gene_name": "anon-EST:GressD1", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": [ { "id": "NP_001027416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027416", "type": "external" } ], "gene_names_uniprotkb": "anon-EST:GressD1; CG13344; Dmel\\CG13344; Dmel_CG13344; anon-EST:GreesD1", "gene_names_refseq": "CG13344; Dmel\\CG13344; anon-EST:GreesD1; anon-EST:GressD1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF25", "protein_names_refseq": "CG13344-PC; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13344); (R-DME-983168)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0009893 positive regulation of metabolic process;GO:0016567 protein ubiquitination;GO:0010468 regulation of gene expression;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A1Z9I6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1ZA92-1", "uniprot_id": [ { "id": "NOL9_DROME", "url": "https://www.uniprot.org/uniprot/A1ZA92", "type": "external" } ], "mass": 111208.0, "length": 995, "protein_name": "Polynucleotide 5'-hydroxyl-kinase Nol9", "gene_name": "Nol9", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_611084", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611084", "type": "external" } ], "gene_names_uniprotkb": "Nol9; CG8414", "gene_names_refseq": "CG8414; Dmel\\CG8414; NOL9", "protein_names_uniprotkb": "Polynucleotide 5'-hydroxyl-kinase Nol9; 2.7.1.-; Nucleolar protein 9 homolog", "protein_names_refseq": "CG8414-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8414); (R-DME-6791226)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Polynucleotide 5'-kinase involved in rRNA processing., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SZP4;V5LWT6", "ec_number_list": [ { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" } ], "go_molecular_function": "GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity;GO:0005524 ATP binding;GO:0051731 polynucleotide 5'-hydroxyl-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0006364 rRNA processing;GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A1ZA92-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1ZAG4-1", "uniprot_id": [ { "id": "PAR16_DROME", "url": "https://www.uniprot.org/uniprot/A1ZAG4", "type": "external" } ], "mass": 40731.0, "length": 359, "protein_name": "Protein mono-ADP-ribosyltransferase Parp16", "gene_name": "Parp16", "organism": "Fruit fly", "refseq_name": "Poly(ADP-ribose) polymerase 16", "refseq_ac": [ { "id": "NP_725583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_725583", "type": "external" } ], "gene_names_uniprotkb": "Parp16; CG15925", "gene_names_refseq": "CG15925; Dmel\\CG15925; Parp16; dARTD15; dPARP16", "protein_names_uniprotkb": "Protein mono-ADP-ribosyltransferase Parp16; 2.4.2.-; PARP-16", "protein_names_refseq": "CG15925-PA; Parp16-PA; Poly(ADP-ribose) polymerase 16; Poly(ADP-ribose) polymerase family member 16", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15925)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;27874829", "class_list": "", "function": "Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes. Required for amino acid starvation-induced mono-ADP-ribosylation and subsequent formation of Sec bodies - which are stress assemblies that promote cell survival by preserving components of the ER exit sites (ERES) during amino-acid starvation. Catalyzes the mono-ADP-ribosylation of Sec16 which is essential for Sec body formation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8T910", "ec_number_list": [ { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" } ], "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0019900 kinase binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0071782 endoplasmic reticulum tubular network", "go_biological_process": "GO:0030968 endoplasmic reticulum unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A1ZAG4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1ZAJ3-1", "uniprot_id": [ { "id": "A1ZAJ3_DROME", "url": "https://www.uniprot.org/uniprot/A1ZAJ3", "type": "external" } ], "mass": 23181.0, "length": 201, "protein_name": "TIL domain-containing protein", "gene_name": "Dmel\\CG5267", "organism": "Fruit fly", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dmel\\CG5267; CG5267; Dmel_CG5267", "gene_names_refseq": "", "protein_names_uniprotkb": "TIL domain-containing protein", "protein_names_refseq": "", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5267)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007320 insemination", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A1ZAJ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1ZAK1-1", "uniprot_id": [ { "id": "INT8_DROME", "url": "https://www.uniprot.org/uniprot/A1ZAK1", "type": "external" } ], "mass": 113480.0, "length": 1007, "protein_name": "Integrator complex subunit 8", "gene_name": "IntS8", "organism": "Fruit fly", "refseq_name": "integrator 8", "refseq_ac": [ { "id": "NP_611162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611162", "type": "external" } ], "gene_names_uniprotkb": "IntS8; CG5859", "gene_names_refseq": "CG5859; Dmel\\CG5859; EG:EG0003.5; Int8; IntS8; intS8; l(2)SH1314; l(2)SH2 1314", "protein_names_uniprotkb": "Integrator complex subunit 8", "protein_names_refseq": "CG5859-PA; IntS8-PA; integrator 8; lethal (2) SH1314", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5859); (R-DME-6807505)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10731132;10731137;12537569;12537572;21078872;23097424;31530651;32966759;37995689;39032490", "class_list": "", "function": "Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:21078872, PubMed:23097424, PubMed:32966759). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity (PubMed:32966759). The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424). Within the integrator complex, INTS8 is required for the recruitment of protein phosphatase 2A (PP2A) to transcription pause-release checkpoint (PubMed:32966759)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O96831;Q95U02", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005694 chromosome;GO:0032039 integrator complex;GO:0160232 INTAC complex", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0045666 positive regulation of neuron differentiation;GO:0030514 negative regulation of BMP signaling pathway;GO:0016180 snRNA processing;GO:0071168 protein localization to chromatin", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "A1ZAK1-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1ZAK8-1", "uniprot_id": [ { "id": "A1ZAK8_DROME", "url": "https://www.uniprot.org/uniprot/A1ZAK8", "type": "external" } ], "mass": 81716.0, "length": 797, "protein_name": "P-element somatic inhibitor, isoform C; P-element somatic inhibitor, isoform E", "gene_name": "Psi", "organism": "Fruit fly", "refseq_name": "P-element somatic inhibitor, isoform C", "refseq_ac": [ { "id": "NP_995862", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_995862", "type": "external" } ], "gene_names_uniprotkb": "Psi; CG8912; Dmel\\CG8912; Dmel_CG8912; EG:EG0003.2; PSI", "gene_names_refseq": "CG8912; Dmel\\CG8912; EG:EG0003.2; PSI; Psi", "protein_names_uniprotkb": "P-element somatic inhibitor, isoform C; P-element somatic inhibitor, isoform E", "protein_names_refseq": "CG8912-PC; P element somatic inhibitor; P-element somatic inhibitor protein; P-element somatic inhibitor, isoform C; P-element somatic; Psi-PC", "tax_id": 7227, "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); colorectal carcinoma (Disease Ontology:DOID:0080199); traumatic brain injury (Disease Ontology:DOID:0081292); stomach cancer (Disease Ontology:DOID:10534); sciatic neuropathy (Disease Ontology:DOID:11446); breast cancer (Disease Ontology:DOID:1612); ovary epithelial cancer (Disease Ontology:DOID:2152); malignant astrocytoma (Disease Ontology:DOID:3069); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684); nasopharynx carcinoma (Disease Ontology:DOID:9261)", "pathway": " (dme:Dmel_CG8912); (R-DME-450604)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0ACD4DAQ1", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0140311 protein sequestering activity;GO:0140517 protein-RNA adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0007283 spermatogenesis;GO:0006355 regulation of DNA-templated transcription;GO:0048025 negative regulation of mRNA splicing, via spliceosome;GO:0048024 regulation of mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A1ZAK8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1ZB86-1", "uniprot_id": [ { "id": "KLD10_DROME", "url": "https://www.uniprot.org/uniprot/A1ZB86", "type": "external" } ], "mass": 69676.0, "length": 609, "protein_name": "Kelch domain-containing protein 10 homolog", "gene_name": "slim", "organism": "Fruit fly", "refseq_name": "scruin like at the midline, isoform A", "refseq_ac": [ { "id": "NP_523782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523782", "type": "external" } ], "gene_names_uniprotkb": "slim; CG5186", "gene_names_refseq": "CG5186; Dmel\\CG5186; Slim; l(2)s1866; slim", "protein_names_uniprotkb": "Kelch domain-containing protein 10 homolog; Scruin like at the midline", "protein_names_refseq": "CG5186-PA; lethal (2) s1866; scruin like at the midline, isoform A; slim-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5186); (R-DME-9954709)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537572;23102700", "class_list": "", "function": "Activates the Pk92B/DASK1-MAPK signaling cascade., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7JR76", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0032874 positive regulation of stress-activated MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A1ZB86-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1ZB91-1", "uniprot_id": [ { "id": "DAAF3_DROME", "url": "https://www.uniprot.org/uniprot/A1ZB91", "type": "external" } ], "mass": 62438.0, "length": 540, "protein_name": "Dynein axonemal assembly factor 3 homolog", "gene_name": "Dnaaf3", "organism": "Fruit fly", "refseq_name": "dynein axonemal assembly factor 3", "refseq_ac": [ { "id": "NP_611336", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611336", "type": "external" } ], "gene_names_uniprotkb": "Dnaaf3; CG17669", "gene_names_refseq": "CG17669; Dmel\\CG17669; Dnaaf3", "protein_names_uniprotkb": "Dynein axonemal assembly factor 3 homolog", "protein_names_refseq": "CG17669-PA; Dnaaf3-PA; dynein axonemal assembly factor 3", "tax_id": 7227, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); primary ciliary dyskinesia 2 (Disease Ontology:DOID:0110626)", "pathway": " (dme:Dmel_CG17669)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;34553759", "class_list": "", "function": "Required for the assembly of axonemal inner and outer dynein arms (PubMed:34553759). Involved in the cytoplasmic preassembly of dyneins into complexes before their transport into cilia (PubMed:34553759). Essential for the development of axonemal dynein motors in the sensory cilium of mechanosensory chordotonal (Ch) neurons and sperm flagellum, and consequently, is required for the mechanotransduction process of hearing and sperm mobility (PubMed:34553759)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B6IDP0;Q5U0U7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0120293 dynein axonemal particle", "go_biological_process": "GO:0044458 motile cilium assembly;GO:1905515 non-motile cilium assembly;GO:0070286 axonemal dynein complex assembly;GO:0120316 sperm flagellum assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A1ZB91-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1ZBT5-1", "uniprot_id": [ { "id": "MED8_DROME", "url": "https://www.uniprot.org/uniprot/A1ZBT5", "type": "external" } ], "mass": 27948.0, "length": 252, "protein_name": "Mediator of RNA polymerase II transcription subunit 8", "gene_name": "MED8", "organism": "Fruit fly", "refseq_name": "mediator complex subunit 8", "refseq_ac": [ { "id": "NP_722456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722456", "type": "external" } ], "gene_names_uniprotkb": "MED8; Arc32; CG13867", "gene_names_refseq": "ARC32; Arc32; CG13867; CG30140; Dmel\\CG13867; MED8; Med8/ARC32; Med8; dARC32", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 8; Mediator complex subunit 8", "protein_names_refseq": "CG13867-PA; MED8-PA; mediator complex subunit 8", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13867)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;16751183", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA and MtnB genes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SZ54", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A1ZBT5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1ZBW7-1", "uniprot_id": [ { "id": "WASC2_DROME", "url": "https://www.uniprot.org/uniprot/A1ZBW7", "type": "external" } ], "mass": 160899.0, "length": 1469, "protein_name": "WASH complex subunit 2", "gene_name": "FAM21", "organism": "Fruit fly", "refseq_name": "family with sequence similarity 21", "refseq_ac": [ { "id": "NP_611496", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611496", "type": "external" } ], "gene_names_uniprotkb": "FAM21; CG16742", "gene_names_refseq": "CG16742; Dmel\\CG16742; FAM21; Fam21; fam21", "protein_names_uniprotkb": "WASH complex subunit 2; Family with sequence similarity 21", "protein_names_refseq": "CG16742-PA; FAM21-PA; family with sequence similarity 21", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG16742)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;17372656;18327897;20498093", "class_list": "", "function": "Acts at least in part as component of the WASH complex which may regulate wash nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q1EC81;Q960K6", "ec_number_list": [], "go_molecular_function": "GO:1901981 phosphatidylinositol phosphate binding;GO:1905394 retromer complex binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0031901 early endosome membrane;GO:0071203 WASH complex", "go_biological_process": "GO:0045785 positive regulation of cell adhesion;GO:0016197 endosomal transport;GO:0036010 protein localization to endosome;GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "A1ZBW7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3RLR0-1", "uniprot_id": [ { "id": "TAL3A_DROME", "url": "https://www.uniprot.org/uniprot/A3RLR0", "type": "external" } ], "mass": 1236.0, "length": 11, "protein_name": "Peptide tarsal-less 3A", "gene_name": "tal-3A", "organism": "Fruit fly", "refseq_name": "tarsal-less 3A", "refseq_ac": [ { "id": "NP_001138052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138052", "type": "external" } ], "gene_names_uniprotkb": "tal-3A; CG42386; pri; tal", "gene_names_refseq": "CG42386; Dm3; Dmel\\CG42386; ORF 3A; ORF3; Pep3; pri; tal-3A; tal", "protein_names_uniprotkb": "Peptide tarsal-less 3A; Peptide polished rice 3", "protein_names_refseq": "CG42386-PA; tal-3A-PA; tarsal-less 3A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42386)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537569;12537572;17439302;17486114;18801356;20647469;21527259;21682860;25344753;26383956", "class_list": "", "function": "One of four peptides (tal-1A, tal-2A, tal-3A and tal-AA) produced from a polycistronic gene that function redundantly in several developmental processes (PubMed:17439302, PubMed:17486114, PubMed:21527259, PubMed:25344753). Required in early stages of leg development for the intercalation of the tarsal segments during the mid-third instar stage and later for tarsal joint formation (PubMed:17439302, PubMed:18801356, PubMed:21527259). Promotes the post-translational modification of ovo isoform B (svb) into its active form which in turn initiates trichome development and promotes tarsal joint development (PubMed:20647469, PubMed:21527259, PubMed:26383956). This is likely due to recruitment of the E3 ubiquitin-protein ligase Ubr3 to svb for ubiquitination of its N-terminus, converting svb into a transcriptional activator (PubMed:26383956). Also enhances interaction of Ubr3 with Diap1 (PubMed:26383956). Required for correct wing and leg formation through its regulation of several genes including those in the Notch signaling pathway (PubMed:18801356, PubMed:21527259, PubMed:21682860). Essential for denticle formation and may have a role in the developmental timing of trichome differentiation (PubMed:17486114, PubMed:25344753). Essential for the development of taenidial folds in the trachea (PubMed:17486114)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007015 actin filament organization;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A3RLR0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CG69-1", "uniprot_id": [ { "id": "UBIQP_DROME", "url": "https://www.uniprot.org/uniprot/P0CG69", "type": "external" } ], "mass": 85799.0, "length": 763, "protein_name": "Polyubiquitin", "gene_name": "Ubi-p63E", "organism": "Fruit fly", "refseq_name": "Ubiquitin-63E, isoform D", "refseq_ac": [ { "id": "NP_001261383", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261383", "type": "external" } ], "gene_names_uniprotkb": "Ubi-p63E; CG11624; DmUbi-p63E; DmUb; Dmel\\CG11624; Dmel_CG11624; UB; Ub-p63E; Ubi-P63e; Ubi-m; Ubi-p; Ubi63E; Ubi63p; Ubip63E; Ubip; Ubiq; Ubp; Ub; magn; ubi-p63E; ubi63E; ubi", "gene_names_refseq": "CG11624; DmUbi-p63E; DmUb; Dmel\\CG11624; UB; Ub-p63E; Ubi-P63e; Ubi-p63E; Ubi-p; Ubi63E; Ubi63p; Ubip63E; Ubip; Ubiq; Ubp; Ub; magn; ubi-p63E; ubi63E; ubi", "protein_names_uniprotkb": "Polyubiquitin", "protein_names_refseq": "CG11624-PD; Ubi-p63E-PD; Ubiquitin-63-E; Ubiquitin-63E, isoform D; Ubiquitin-polymeric; magellan; polyubiquitin; ubiquitin 63E; ubiquitin-63E; ubiquitin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11624); (R-DME-110312); (R-DME-110314); (R-DME-110320); (R-DME-1169091); (R-DME-1234176); (R-DME-1253288); (R-DME-1295596); (R-DME-1358803); (R-DME-174048); (R-DME-174084); (R-DME-174113); (R-DME-174154); (R-DME-174178); (R-DME-174184); (R-DME-179409); (R-DME-182971); (R-DME-187577); (R-DME-195253); (R-DME-202424); (R-DME-209360); (R-DME-209447); (R-DME-209461); (R-DME-209560); (R-DME-2122948); (R-DME-214399); (R-DME-216167); (R-DME-2173788); (R-DME-2173791); (R-DME-2173795); (R-DME-2173796); (R-DME-2467813); (R-DME-2559582); (R-DME-2565942); (R-DME-2871837); (R-DME-3134975); (R-DME-3769402); (R-DME-382556); (R-DME-432395); (R-DME-432524); (R-DME-445989); (R-DME-450302); (R-DME-450321); (R-DME-450408); (R-DME-4608870); (R-DME-4641257); (R-DME-4641258); (R-DME-5205685); (R-DME-532668); (R-DME-5357905); (R-DME-5358346); (R-DME-538864); (R-DME-5607761); (R-DME-5607764); (R-DME-5610780); (R-DME-5610785); (R-DME-5632684); (R-DME-5654726); (R-DME-5654727); (R-DME-5654732); (R-DME-5654733); (R-DME-5655862); (R-DME-5656121); (R-DME-5656169); (R-DME-5675221); (R-DME-5675482); (R-DME-5676590); (R-DME-5689603); (R-DME-5689877); (R-DME-5689880); (R-DME-5689896); (R-DME-5689901); (R-DME-5696394); (R-DME-5696395); (R-DME-5696400); (R-DME-6781823); (R-DME-6782135); (R-DME-6782210); (R-DME-6804757); (R-DME-68867); (R-DME-68949); (R-DME-69017); (R-DME-69231); (R-DME-69601); (R-DME-75815); (R-DME-8849469); (R-DME-8854050); (R-DME-8856825); (R-DME-8856828); (R-DME-8863795); (R-DME-8866427); (R-DME-8866652); (R-DME-8866654); (R-DME-8939236); (R-DME-8939902); (R-DME-8941858); (R-DME-8948747); (R-DME-8948751); (R-DME-8951664); (R-DME-901032); (R-DME-9010553); (R-DME-9020702); (R-DME-9033241); (R-DME-912631); (R-DME-917729); (R-DME-917937); (R-DME-937039); (R-DME-937042); (R-DME-937072); (R-DME-9646399); (R-DME-9648002); (R-DME-9664873); (R-DME-975144); (R-DME-975163); (R-DME-9755511); (R-DME-9762114); (R-DME-9770562); (R-DME-983168); (R-DME-9861718); (R-DME-9929491); (R-DME-9932298); (R-DME-9954709); (R-DME-9954716); (R-DME-9958825)", "pathway_count": 124, "publication_count": 42, "publication_id_list": "10102270;10417378;10458606;10481010;10731132;11018014;11585911;12231619;12432393;12442174;12537568;12537572;12537573;12537574;12732719;14519762;15178801;15258584;15331761;16081424;16110336;16299518;16311020;16326393;16386907;16651542;16740475;16794082;16894030;17102630;17158449;17569856;17569867;17925225;18519643;18593878;19185492;2463465;25589440;26109356;26109357;9215627", "class_list": "", "function": "Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P68198;Q0E8I1;Q9VKW6;Q9VQX7;Q9VZL4", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0022626 cytosolic ribosome;GO:0005737 cytoplasm", "go_biological_process": "GO:0016236 macroautophagy;GO:0016567 protein ubiquitination;GO:0019941 modification-dependent protein catabolic process;GO:0035096 larval midgut cell programmed cell death;GO:0010623 programmed cell death involved in cell development", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "P0CG69-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12613-1", "uniprot_id": [ { "id": "TCPA_DROME", "url": "https://www.uniprot.org/uniprot/P12613", "type": "external" } ], "mass": 59557.0, "length": 557, "protein_name": "T-complex protein 1 subunit alpha", "gene_name": "CCT1", "organism": "Fruit fly", "refseq_name": "chaperonin containing TCP1 subunit 1, isoform A", "refseq_ac": [ { "id": "NP_524450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524450", "type": "external" } ], "gene_names_uniprotkb": "CCT1; BEST:GH05123; CCT-1; CG5374; Cct1; Dmel\\CG5374; Dmel_CG5374; T-CP1; T-cp1; T-cpl; TCP-1alpha; TCP1-alpha; TCP1alpha; TCPA_DROME; Tcp-1; Tcp1-alpha; Tcp1-like; Tcp1; cct1; gh05123; tcp1", "gene_names_refseq": "BEST:GH05123; CCT1; CG5374; Cct1; Dmel\\CG5374; T-CP1; T-cp1; T-cpl; TCP-1alpha; TCP1-alpha; TCP1alpha; TCPA_DROME; Tcp-1; Tcp1-alpha; Tcp1-like; Tcp1; cct1; gh05123; tcp1", "protein_names_uniprotkb": "T-complex protein 1 subunit alpha; CCT-alpha; Chaperonin containing TCP1 subunit 1; TCP-1-alpha", "protein_names_refseq": "CCT1-PA; CG5374-PA; T-complex 1; Tcp1-like; chaperonin containing TCP1 subunit 1, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5374); (R-DME-390471); (R-DME-6814122)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;3146529", "class_list": "", "function": "Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VCZ6", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0140662 ATP-dependent protein folding chaperone", "go_cellular_component": "GO:0005829 cytosol;GO:0005832 chaperonin-containing T-complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006457 protein folding;GO:0030707 follicle cell of egg chamber development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P12613-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O61492-1", "uniprot_id": [ { "id": "FLOT2_DROME", "url": "https://www.uniprot.org/uniprot/O61492", "type": "external" } ], "mass": 48158.0, "length": 438, "protein_name": "Flotillin-2", "gene_name": "Flo2", "organism": "Fruit fly", "refseq_name": "flotillin 2, isoform H", "refseq_ac": [ { "id": "NP_001162759", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162759", "type": "external" } ], "gene_names_uniprotkb": "Flo2; CG11547; CG14409; CG32593; DmFlo2; Dmel\\CG32593; Dmel_CG32593; FLO2; FLODm-2; FLO[Dm]-2; Flo-2; Flo; flo2; mdcds_54791; reggie-1", "gene_names_refseq": "CG11547; CG14409; CG32593; DmFlo2; Dmel\\CG32593; FLO2; FLO[Dm]-2; Flo-2; Flo2; Flo; flo2; mdcds_54791; reggie-1", "protein_names_uniprotkb": "Flotillin-2", "protein_names_refseq": "CG32593-PH; Flo2-PH; Flotillin-2; flotillin 2, isoform H; flotillin 2; flotillin2; flottilin 2; reggie-1; reggie1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32593); (R-DME-8849932); (R-DME-8980692)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;9573373", "class_list": "", "function": "May play a role in axon growth and regeneration. May be involved in epidermal cell adhesion and epidermal structure and function., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0KHS9;Q8SZW0;Q9I7S0;Q9VXZ9", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0016600 flotillin complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0072659 protein localization to plasma membrane;GO:0051491 positive regulation of filopodium assembly;GO:0045661 regulation of myoblast differentiation;GO:0035011 melanotic encapsulation of foreign target", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O61492-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26308-1", "uniprot_id": [ { "id": "GBB1_DROME", "url": "https://www.uniprot.org/uniprot/P26308", "type": "external" } ], "mass": 37133.0, "length": 340, "protein_name": "Guanine nucleotide-binding protein subunit beta-1", "gene_name": "Gbeta13F", "organism": "Fruit fly", "refseq_name": "G protein beta subunit 13F, isoform H", "refseq_ac": [ { "id": "NP_001303567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303567", "type": "external" } ], "gene_names_uniprotkb": "Gbeta13F; 4 like; CG10545; Dmel\\CG10545; Dmel_CG10545; G b13F; G protein &bgr; G-betab; G-beta; G[[beta13F]]; G[[beta]]; Gb13F; Gbb; Gbeta13; Gbeta; anon-EST:Liang-1.22; clone 1.22; dgbeta; gbeta13F", "gene_names_refseq": "CG10545; Dmel\\CG10545; G b13F; G protein &bgr; G-betab; G-beta; GNB1/2/3/4 like; G[[beta13F]]; G[[beta]]; Gb13F; Gbb; Gbeta13F; Gbeta13; Gbeta; anon-EST:Liang-1.22; clone 1.22; dgbeta; gbeta13F", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit beta-1", "protein_names_refseq": "CG10545-PH; G protein beta subunit 13F, isoform H; G protein beta subunit; G protein beta-subunit 13F; G-protein beta 13F; G[[beta]] brain; Gbeta13F-PH", "tax_id": 7227, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); autosomal dominant intellectual developmental disorder 42 (Disease Ontology:DOID:0070072); Charcot-Marie-Tooth disease dominant intermediate F (Disease Ontology:DOID:0110206); congenital stationary night blindness 1H (Disease Ontology:DOID:0110866); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); familial hyperlipidemia (Disease Ontology:DOID:1168); depressive disorder (Disease Ontology:DOID:1596); carotid artery disease (Disease Ontology:DOID:3407); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dme:Dmel_CG10545); (R-DME-1296041); (R-DME-418594); (R-DME-418597); (R-DME-428930); (R-DME-6814122); (R-DME-8964616); (R-DME-997272)", "pathway_count": 8, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;1910788;25589440;26109356;26109357;3140235", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VXM8", "ec_number_list": [], "go_molecular_function": "GO:0030159 signaling receptor complex adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0010470 regulation of gastrulation;GO:0007186 G protein-coupled receptor signaling pathway;GO:0055059 asymmetric neuroblast division;GO:0045879 negative regulation of smoothened signaling pathway;GO:0043519 regulation of myosin II filament organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P26308-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4VCL2-2", "uniprot_id": [ { "id": "FA20C_DROME", "url": "https://www.uniprot.org/uniprot/A4VCL2", "type": "external" } ], "mass": 59415.0, "length": 528, "protein_name": "Extracellular serine/threonine protein CG31145", "gene_name": "CG31145", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": [ { "id": "NP_001138101", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138101", "type": "external" } ], "gene_names_uniprotkb": "CG31145", "gene_names_refseq": "CG10187; CG13820; CG13821; CG31145; Dmel\\CG31145", "protein_names_uniprotkb": "Extracellular serine/threonine protein CG31145; 2.7.11.1; GEF-CK; Golgi casein kinase; Golgi-enriched fraction casein kinase", "protein_names_refseq": "CG31145-PC; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "X-linked hypophosphatemic rickets (Disease Ontology:DOID:0050445); amelogenesis imperfecta type 1G (Disease Ontology:DOID:0110066); rickets (Disease Ontology:DOID:10609); amelogenesis imperfecta (Disease Ontology:DOID:2187)", "pathway": " (dme:Dmel_CG31145); (R-DME-381426); (R-DME-8957275)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10731132;12537572;22900076", "class_list": "", "function": "Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B7Z0P4;B7Z0P6;C1C534;Q9VCK5", "ec_number_list": [ { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.14.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.18.1", "type": "external" }, { "id": "1.10.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.10.3.1", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "1.10.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.10.3.3", "type": "external" }, { "id": "3.4.21.112", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.112", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" }, { "id": "3.1.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.98", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005794 Golgi apparatus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A4VCL2-2", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8DYT6-1", "uniprot_id": [ { "id": "A8DYT6_DROME", "url": "https://www.uniprot.org/uniprot/A8DYT6", "type": "external" } ], "mass": 13290.0, "length": 116, "protein_name": "Protein C10", "gene_name": "Dmel\\CG15387", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_001097058", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097058", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG15387; CG15387; Dmel_CG15387", "gene_names_refseq": "CG15387; Dmel\\CG15387", "protein_names_uniprotkb": "Protein C10", "protein_names_refseq": "CG15387-PB; uncharacterized protein", "tax_id": 7227, "disease": "Temtamy syndrome (Disease Ontology:DOID:0111621)", "pathway": " (dme:Dmel_CG15387)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009791 post-embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A8DYT6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M9PCB8-1", "uniprot_id": [ { "id": "M9PCB8_DROME", "url": "https://www.uniprot.org/uniprot/M9PCB8", "type": "external" } ], "mass": 190335.0, "length": 1805, "protein_name": "Uncharacterized protein", "gene_name": "CG13768; CG13769; CT33252; Dmel\\CG31635", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": [ { "id": "NP_001260135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260135", "type": "external" } ], "gene_names_uniprotkb": "CG13768; CG13769; CT33252; Dmel\\CG31635; BcDNA:GM03875; CG13768; CG13769; CG31635; CT33252; Dmel\\CG31635; Dmel_CG31635", "gene_names_refseq": "BcDNA:GM03875; CG13768; CG13769; CG31635; CT33252; Dmel\\CG31635", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG31635-PC; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31635)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "M9PCB8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07553-1", "uniprot_id": [ { "id": "GCY3E_DROME", "url": "https://www.uniprot.org/uniprot/Q07553", "type": "external" } ], "mass": 130915.0, "length": 1163, "protein_name": "Guanylate cyclase 32E", "gene_name": "Gyc32E", "organism": "Fruit fly", "refseq_name": "guanylyl cyclase at 32E, isoform D", "refseq_ac": [ { "id": "NP_788027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788027", "type": "external" } ], "gene_names_uniprotkb": "Gyc32E; CG33114; CG6275; Cyg1; DMRGC; Dmel\\CG33114; Dmel_CG33114; GC; GYC 32E; Gyc-r", "gene_names_refseq": "CG33114; CG6275; Cyg1; DMRGC; Dmel\\CG33114; GC; GYC 32E; Gyc-r; Gyc32E", "protein_names_uniprotkb": "Guanylate cyclase 32E; 4.6.1.2", "protein_names_refseq": "CG33114-PD; Gyc32E-PD; guanyl cyclase at 32E; guanylate cyclase receptor-type; guanylyl cyclase at 32E, isoform D", "tax_id": 7227, "disease": "abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); congenital diarrhea 6 (Disease Ontology:DOID:0060780); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG33114)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8104831", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9VKI9", "ec_number_list": [ { "id": "4.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0038023 signaling receptor activity;GO:0001653 peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007168 receptor guanylyl cyclase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q07553-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17970-1", "uniprot_id": [ { "id": "KCNAB_DROME", "url": "https://www.uniprot.org/uniprot/P17970", "type": "external" } ], "mass": 109786.0, "length": 1015, "protein_name": "Potassium voltage-gated channel protein Shab", "gene_name": "Shab", "organism": "Fruit fly", "refseq_name": "shaker cognate b, isoform B", "refseq_ac": [ { "id": "NP_523894", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523894", "type": "external" } ], "gene_names_uniprotkb": "Shab; CG1066; CG43128; CG9965; Dmel\\CG43128; Dmel_CG43128; K[[v]]2; Kv2; dShab; shab; shb", "gene_names_refseq": "CG1066; CG43128; CG9965; Dmel\\CG43128; K[[v]]2; Kv2; Shab; dShab; shab; shb", "protein_names_uniprotkb": "Potassium voltage-gated channel protein Shab", "protein_names_refseq": "CG43128-PB; Shab-PB; shaker cognate b, isoform B; shaker", "tax_id": 7227, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); developmental and epileptic encephalopathy 26 (Disease Ontology:DOID:0080461); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dme:Dmel_CG43128); (R-DME-1296072); (R-DME-381676)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10419540;10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;2333511;2336395;2493160;25589440;26109356;26109357", "class_list": "", "function": "Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient., [UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 8, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "O76805;Q9I7T9;Q9I7U0", "ec_number_list": [], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0015459 potassium channel regulator activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0007268 chemical synaptic transmission;GO:0045938 positive regulation of circadian sleep/wake cycle, sleep;GO:0008016 regulation of heart contraction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P17970-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8JQX3-1", "uniprot_id": [ { "id": "NOCT_DROME", "url": "https://www.uniprot.org/uniprot/A8JQX3", "type": "external" } ], "mass": 71880.0, "length": 642, "protein_name": "Nocturnin", "gene_name": "cu", "organism": "Fruit fly", "refseq_name": "curled, isoform C", "refseq_ac": [ { "id": "NP_001097745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097745", "type": "external" } ], "gene_names_uniprotkb": "cu; CG31299", "gene_names_refseq": "CG31299; CG4782; CG4796; Dmel\\CG31299; Noct; cu; no(cu); nocturnin; noct; noc; no", "protein_names_uniprotkb": "Nocturnin; 3.1.3.-; Curled", "protein_names_refseq": "CG31299-PC; cu-PC; curled, isoform C; dnocturnin; nocturin; nocturnin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31299)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;11747467;12537569;12537572;19581445;19966839;20504953;31147539", "class_list": "", "function": "Doesn't have a role in light-mediated behavioral response., [UniProtKB, PubMed]; In dorsal neurons, contributes to the light-mediated behavioral response., [UniProtKB, PubMed]; Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (PubMed:31147539). Shows a small preference for NADPH over NADP(+) (PubMed:31147539). Because of its association with the CCR4-NOT complex, has a role in mRNA deadenylation and decay (PubMed:20504953). Required at the pupal stage for proper wing morphogenesis after eclosion (PubMed:19581445)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4KH43;A0A0C4DHA6;C0PPK5;Q3ZAP4;Q6AWF6;Q8MTZ6", "ec_number_list": [ { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0019178 NADP phosphatase activity;GO:0102757 NADPH phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0045475 locomotor rhythm;GO:0009416 response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "A8JQX3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8JUV7-1", "uniprot_id": [ { "id": "A8JUV7_DROME", "url": "https://www.uniprot.org/uniprot/A8JUV7", "type": "external" } ], "mass": 120915.0, "length": 1105, "protein_name": "Interference hedgehog", "gene_name": "boi", "organism": "Fruit fly", "refseq_name": "brother of ihog, isoform G", "refseq_ac": [ { "id": "NP_001096868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096868", "type": "external" } ], "gene_names_uniprotkb": "boi; Boi; CG13756; CG32796; CG7894; CT23737; CT33235; Dmel\\CG32796; Dmel_CG32796; EG:BACH59J11.2", "gene_names_refseq": "Boi; CG13756; CG32796; CG7894; CT23737; CT33235; Dmel\\CG32796; EG:BACH59J11.2; boi", "protein_names_uniprotkb": "Interference hedgehog", "protein_names_refseq": "CG32796-PG; boi-PG; brother of iHog; brother of ihog, isoform G", "tax_id": 7227, "disease": "holoprosencephaly 11 (Disease Ontology:DOID:0110877)", "pathway": " (dme:Dmel_CG32796); (R-DME-209214); (R-DME-209338); (R-DME-447043); (R-DME-6798695)", "pathway_count": 5, "publication_count": 29, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;12663920;14523402;14597665;14614827;14636583;15300262;15563523;15592457;15598741;15616566;15875013;16041759;16110336;16630821;17077139;17182028;17569856;17569867;25589440;26109356;26109357;8898207;8906787;8906794", "class_list": "", "function": "Mediates response to the active Hedgehog (Hh) protein signal in embryos, functioning upstream or at the level of patched (ptc)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0097108 hedgehog family protein binding;GO:0008201 heparin binding;GO:0015026 coreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0035230 cytoneme", "go_biological_process": "GO:0048749 compound eye development;GO:0098609 cell-cell adhesion;GO:0007224 smoothened signaling pathway;GO:0007411 axon guidance;GO:0001751 compound eye photoreceptor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 3.0, "record_id": "A8JUV7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8Y548-1", "uniprot_id": [ { "id": "A8Y548_DROME", "url": "https://www.uniprot.org/uniprot/A8Y548", "type": "external" } ], "mass": 38415.0, "length": 340, "protein_name": "Chitin-binding type-4 domain-containing protein", "gene_name": "Dmel\\CG41284", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_001104417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104417", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG41284; CG41284; Dmel_CG41284", "gene_names_refseq": "CG41284; Dmel\\CG41284", "protein_names_uniprotkb": "Chitin-binding type-4 domain-containing protein", "protein_names_refseq": "CG41284-PC; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG41284)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "A8Y548-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B7YZU2-1", "uniprot_id": [ { "id": "LINT_DROME", "url": "https://www.uniprot.org/uniprot/B7YZU2", "type": "external" } ], "mass": 182674.0, "length": 1693, "protein_name": "Serine protease filzig", "gene_name": "flz", "organism": "Fruit fly", "refseq_name": "filzig, isoform C", "refseq_ac": [ { "id": "NP_001137622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137622", "type": "external" } ], "gene_names_uniprotkb": "flz; CG8213; lint", "gene_names_refseq": "CG8213; Dmel\\CG8213; SP44; c-SP44; cSP44; flz; lint", "protein_names_uniprotkb": "Serine protease filzig; 3.4.21.-; Lumens interrupted", "protein_names_refseq": "CG8213-PC; filzig, isoform C; flz-PC; lumens interrupted", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8213); (R-DME-1592389); (R-DME-9855719)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;29309404", "class_list": "", "function": "Probable endopeptidase. In tracheal terminal cells, acts downstream of ich to regulate seamless tube growth and/or maintenance probably by processing lumenal matrix proteins., [UniProtKB, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 4, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4LFV3;A1Z7M1;Q8SY35", "ec_number_list": [ { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098595 perivitelline space", "go_biological_process": "GO:0060439 trachea morphogenesis;GO:0006508 proteolysis;GO:0016485 protein processing;GO:0035149 lumen formation, open tracheal system", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "B7YZU2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B7YZV4-1", "uniprot_id": [ { "id": "PDE1_DROME", "url": "https://www.uniprot.org/uniprot/B7YZV4", "type": "external" } ], "mass": 91455.0, "length": 834, "protein_name": "Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1", "gene_name": "Pde1c", "organism": "Fruit fly", "refseq_name": "phosphodiesterase 1c, isoform B", "refseq_ac": [ { "id": "NP_001137816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137816", "type": "external" } ], "gene_names_uniprotkb": "Pde1c; CG14940; CG14942; CG14943; CG14944; CG31757; CG31758; CG42325; CG44007; Dmel\\CG44007; Dmel_CG44007; FBgn0264815; PDE1C; PDE1c; PDE1; mdcds_1440", "gene_names_refseq": "CG14940; CG14942; CG14943; CG14944; CG31757; CG31758; CG42325; CG44007; Dmel\\CG44007; FBgn0264815; PDE1C; PDE1c; PDE1; Pde1c; mdcds_1440", "protein_names_uniprotkb": "Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1; 3.1.4.17; PDE1", "protein_names_refseq": "CG44007-PB; Pde1c-PB; phosphodiesterase 1c, isoform B", "tax_id": 7227, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); autosomal dominant nonsyndromic deafness 74 (Disease Ontology:DOID:0112165)", "pathway": " (dme:Dmel_CG44007); (R-DME-111957); (R-DME-418457); (R-DME-418555)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15673286;16110336;17569856;17569867;20551439;25589440;26109356;26109357", "class_list": "", "function": "Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:15673286). Required for male fertility and male mating behavior (PubMed:20551439)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9VKE9", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity;GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060179 male mating behavior;GO:0046058 cAMP metabolic process;GO:0007320 insemination;GO:0007165 signal transduction;GO:0046068 cGMP metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "B7YZV4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B7Z002-1", "uniprot_id": [ { "id": "B7Z002_DROME", "url": "https://www.uniprot.org/uniprot/B7Z002", "type": "external" } ], "mass": 593443.0, "length": 5517, "protein_name": "Kismet, isoform C", "gene_name": "kis", "organism": "Fruit fly", "refseq_name": "kismet, isoform C", "refseq_ac": [ { "id": "NP_001137761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137761", "type": "external" } ], "gene_names_uniprotkb": "kis; 2532; 31; 5841; BEST:GM02209; CG18326; CG3660; CG3696; DmelPex20; Dmel\\CG3696; Dmel_CG3696; EC2-7; EK2-4; EP(2)0474; EP474; FBtr0078144; GM02209; KIS-L; KIS; Kismet; Kis; Pex20; Su(Pc)21AB; anon-WO0172774.164; anon-WO0257455.5; kiss; l(2)07812; l(2)k08827; l(2)k11324; l(2)k13631; l(2)k14112; l(2)k16510; l(2)s3527; l(2)s4771; l(2)s4793", "gene_names_refseq": "136/31; 2532; 5841; BEST:GM02209; CG18326; CG3660; CG3696; DmelPex20; Dmel\\CG3696; EC2-7; EK2-4; EP(2)0474; EP474; FBtr0078144; GM02209; KIS-L; KIS; Kismet; Kis; Pex20; Su(Pc)21AB; anon-WO0172774.164; anon-WO0257455.5; kiss; kis; l(2)07812; l(2)k08827; l(2)k11324; l(2)k13631; l(2)k14112; l(2)k16510; l(2)s3527; l(2)s4771; l(2)s4793", "protein_names_uniprotkb": "Kismet, isoform C", "protein_names_refseq": "CG3696-PC; EP474; Kismet-L; kis-PC; kismet, isoform C; kismet; lethal (2) k11324; lethal (2) k16510; peroxin 20", "tax_id": 7227, "disease": "CHARGE syndrome (Disease Ontology:DOID:0050834); autism spectrum disorder (Disease Ontology:DOID:0060041); hypogonadotropic hypogonadism 5 with or without anosmia (Disease Ontology:DOID:0090084); congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (dme:Dmel_CG3696); (R-DME-3769402); (R-DME-9943962)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;33925313;40245499", "class_list": "", "function": "", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 4, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0000791 euchromatin", "go_biological_process": "GO:0034728 nucleosome organization;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "B7Z002-1", "record_type": "protein", "filter_code": "0000000.0000111.000100.000000100000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17972-1", "uniprot_id": [ { "id": "KCNAW_DROME", "url": "https://www.uniprot.org/uniprot/P17972", "type": "external" } ], "mass": 56509.0, "length": 498, "protein_name": "Potassium voltage-gated channel protein Shaw", "gene_name": "Shaw", "organism": "Fruit fly", "refseq_name": "shaker cognate w, isoform A", "refseq_ac": [ { "id": "NP_476721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476721", "type": "external" } ], "gene_names_uniprotkb": "Shaw; CG15419; CG2822; Dmel\\CG2822; Dmel_CG2822; K[[v]]3; Kv3.1; Kv3; SHAW2; Shaw2; dShaw2; dShaw; shaw", "gene_names_refseq": "CG15419; CG2822; Dmel\\CG2822; K[[v]]3; Kv3.1; Kv3; Shaw2; Shaw; dShaw2; dShaw; shaw", "protein_names_uniprotkb": "Potassium voltage-gated channel protein Shaw; Shaw2", "protein_names_refseq": "CG2822-PA; Shaw-PA; shaker cognate w, isoform A", "tax_id": 7227, "disease": "spinocerebellar ataxia 13 (Disease Ontology:DOID:0050963); developmental and epileptic encephalopathy 103 (Disease Ontology:DOID:0070389); progressive myoclonus epilepsy 7 (Disease Ontology:DOID:0111447); Alzheimer's disease (Disease Ontology:DOID:10652); sciatic neuropathy (Disease Ontology:DOID:11446); status epilepticus (Disease Ontology:DOID:1824); glioblastoma (Disease Ontology:DOID:3068)", "pathway": " (dme:Dmel_CG2822); (R-DME-1296072); (R-DME-381676)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;2333511;2336395;25589440;26109356;26109357", "class_list": "", "function": "Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9VQU5", "ec_number_list": [], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0005249 voltage-gated potassium channel activity;GO:0022843 voltage-gated monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043679 axon terminus;GO:0045211 postsynaptic membrane;GO:0008076 voltage-gated potassium channel complex;GO:0032809 neuronal cell body membrane", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0006813 potassium ion transport;GO:0030431 sleep;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P17972-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24537-1", "uniprot_id": [ { "id": "HMG2_DROME", "url": "https://www.uniprot.org/uniprot/Q24537", "type": "external" } ], "mass": 44935.0, "length": 393, "protein_name": "High mobility group protein DSP1", "gene_name": "Dsp1", "organism": "Fruit fly", "refseq_name": "dorsal switch protein 1, isoform G", "refseq_ac": [ { "id": "NP_001285322", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285322", "type": "external" } ], "gene_names_uniprotkb": "Dsp1; CG12223; DSP1; Dmel\\CG12223; Dmel_CG12223; HMGB1; HMGD1; Hmg14B; Hmg14D; Ssrp2; dsp1; hmg; ssrp2", "gene_names_refseq": "CG12223; DSP1; Dmel\\CG12223; Dsp1; HMGB1; HMGD1; Hmg14B; Hmg14D; Ssrp2; dsp1; hmg; ssrp2", "protein_names_uniprotkb": "High mobility group protein DSP1; Protein dorsal switch 1", "protein_names_refseq": "CG12223-PG; Dsp1-PG; Hmg14B; dorsal switch protein 1, isoform G; dorsal switch protein 1; dorsal switch protein-1; structure specific recognition protein 2", "tax_id": 7227, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); syndromic microphthalmia 13 (Disease Ontology:DOID:0111811); hydrocephalus (Disease Ontology:DOID:10908); sciatic neuropathy (Disease Ontology:DOID:11446); Kawasaki disease (Disease Ontology:DOID:13378); obstructive jaundice (Disease Ontology:DOID:13603); alcohol use disorder (Disease Ontology:DOID:1574); atherosclerosis (Disease Ontology:DOID:1936); colon adenocarcinoma (Disease Ontology:DOID:234); high grade glioma (Disease Ontology:DOID:3070); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); brain infarction (Disease Ontology:DOID:3454); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); systemic scleroderma (Disease Ontology:DOID:418); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); periodontitis (Disease Ontology:DOID:824)", "pathway": " (dme:Dmel_CG12223); (R-DME-209394)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10409696;10731132;11269501;12537568;12537569;12537572;12537573;12537574;12732719;15640802;16110336;17569856;17569867;17803358;25589440;26109356;26109357;8072548;9031641", "class_list": "", "function": "Binds preferentially single-stranded DNA and unwinds double-stranded DNA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 19, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V4L8;Q23998;Q24285;Q95SD7", "ec_number_list": [], "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003677 DNA binding;GO:0017025 TBP-class protein binding;GO:0003697 single-stranded DNA binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005700 polytene chromosome;GO:0005694 chromosome", "go_biological_process": "GO:0017055 negative regulation of RNA polymerase II transcription preinitiation complex assembly;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0045892 negative regulation of DNA-templated transcription;GO:0032502 developmental process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q24537-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77086-1", "uniprot_id": [ { "id": "C3G_DROME", "url": "https://www.uniprot.org/uniprot/O77086", "type": "external" } ], "mass": 172071.0, "length": 1571, "protein_name": "Guanine nucleotide-releasing factor 2", "gene_name": "C3G", "organism": "Fruit fly", "refseq_name": "C3G guanyl-nucleotide exchange factor, isoform H", "refseq_ac": [ { "id": "NP_572350", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572350", "type": "external" } ], "gene_names_uniprotkb": "C3G; C(3)G; CG14436; CG3126; CG42328; DC3-G; DC3G; Dmel\\CG42328; Dmel_CG42328; c(3)G", "gene_names_refseq": "C(3)G; C3G; CG14436; CG3126; CG42328; DC3-G; DC3G; Dmel\\CG42328; c(3)G", "protein_names_uniprotkb": "Guanine nucleotide-releasing factor 2; CRK SH3-binding GNRP; DC3G", "protein_names_refseq": "C3G guanyl-nucleotide exchange factor, isoform H; C3G ortholog; C3G-PH; CG42328-PH", "tax_id": 7227, "disease": "anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783)", "pathway": " (dme:Dmel_CG42328); (R-DME-186763); (R-DME-9013423); (R-DME-912631)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;9878058", "class_list": "", "function": "Guanine nucleotide-releasing protein that binds to SH3 domain of Crk. Transduces signals from Crk to activate RAS. Also involved in MAPK activation., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q1ECB6;Q7YU30;Q86B63;Q9W3W3", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007525 somatic muscle development;GO:0045880 positive regulation of smoothened signaling pathway;GO:0032486 Rap protein signal transduction;GO:0010976 positive regulation of neuron projection development;GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O77086-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C0HKA3-1", "uniprot_id": [ { "id": "TRYGT_DROME", "url": "https://www.uniprot.org/uniprot/C0HKA3", "type": "external" } ], "mass": 25680.0, "length": 253, "protein_name": "Trypsin gamma", "gene_name": "gammaTry", "organism": "Fruit fly", "refseq_name": "gammaTrypsin", "refseq_ac": [ { "id": "NP_725034", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_725034", "type": "external" } ], "gene_names_uniprotkb": "gammaTry; CG30028", "gene_names_refseq": "BcDNA:RE40325; CG30028; DmGammaTry; Dmel\\CG30028; GammaTry; SP180; SPH180; Try; endo-I; gamma-Try; gammaTry; gamma", "protein_names_uniprotkb": "Trypsin gamma; 3.4.21.4", "protein_names_refseq": "CG30028-PA; endoproteinase I; gammaTry-PA; gammaTrypsin; gummaTrypsin", "tax_id": 7227, "disease": "amelogenesis imperfecta type 2A1 (Disease Ontology:DOID:0110057); prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394)", "pathway": " (dme:Dmel_CG12351); (dme:Dmel_CG30028); (dme:Dmel_CG30031)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10486967;10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P42276;P42277;Q8SXZ4;Q9V5Y4", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "C0HKA3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C0HKA4-1", "uniprot_id": [ { "id": "Y0031_DROME", "url": "https://www.uniprot.org/uniprot/C0HKA4", "type": "external" } ], "mass": 25680.0, "length": 253, "protein_name": "Trypsin delta/gamma-like protein CG30031", "gene_name": "CG30031", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_725035", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_725035", "type": "external" } ], "gene_names_uniprotkb": "CG30031", "gene_names_refseq": "CG30031; Dmel\\CG30031; SP6; endo-I", "protein_names_uniprotkb": "Trypsin delta/gamma-like protein CG30031; 3.4.21.4", "protein_names_refseq": "CG30031-PA; endoproteinase I; uncharacterized protein", "tax_id": 7227, "disease": "amelogenesis imperfecta type 2A1 (Disease Ontology:DOID:0110057); prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394)", "pathway": " (dme:Dmel_CG12351); (dme:Dmel_CG30028); (dme:Dmel_CG30031)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P42276;P42277;Q8SXZ4;Q9V5Y4", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "C0HKA4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C0HL62-1", "uniprot_id": [ { "id": "LCP51_DROME", "url": "https://www.uniprot.org/uniprot/C0HL62", "type": "external" } ], "mass": 11267.0, "length": 104, "protein_name": "Larval cuticle protein 65Ab1", "gene_name": "Lcp65Ab1", "organism": "Fruit fly", "refseq_name": "Lcp65Ab1", "refseq_ac": [ { "id": "NP_524814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524814", "type": "external" } ], "gene_names_uniprotkb": "Lcp65Ab1; 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CG5825", "gene_names_refseq": "CG5825; Dmel\\CG5825; H3.3 A; H3.3A; H3.3; His-3.3A; His3.3A; His3.3; PH3; dH3.3A", "protein_names_uniprotkb": "Histone H3.3A; H3.A", "protein_names_refseq": "CG5825-PC; H3L-like histone; His3.3A-PC; histone H3.3 variant; histone H3.3A, isoform C; histone H3.3A; histone H3.3; histone variant 3.3; histone variant H3.3", "tax_id": 7227, "disease": "Bryant-Li-Bhoj neurodevelopmental syndrome 1 (Disease Ontology:DOID:0051011); Bryant-Li-Bhoj neurodevelopmental syndrome 2 (Disease Ontology:DOID:0051012); diffuse midline glioma, H3 K27-altered (Disease Ontology:DOID:0080684)", "pathway": " (dme:Dmel_CG5825); (dme:Dmel_CG8989); (R-DME-212300); (R-DME-2559580); (R-DME-2559582); (R-DME-427359); (R-DME-427413); (R-DME-5578749); (R-DME-5625886); (R-DME-68616); (R-DME-73772); (R-DME-8936459); (R-DME-9018519); (R-DME-9764725); (R-DME-983231); (R-DME-9841922); (R-DME-9843940); (R-DME-9909649); (R-DME-9940951); (R-DME-9943411); (R-DME-9943962)", "pathway_count": 21, "publication_count": 12, "publication_id_list": "10731132;11114889;11266459;11371341;12514098;12537569;12537572;14732680;15371351;22389435;36930688;7557364", "class_list": "", "function": "Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes and is specifically enriched in modifications associated with active chromatin. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V466;E2QCP0;P06351;P33155;P84249;Q9V3W4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore;GO:0000786 nucleosome;GO:0005700 polytene chromosome", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0006334 nucleosome assembly;GO:0007080 mitotic metaphase chromosome alignment;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "C0HL66-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C0HL67-1", "uniprot_id": [ { "id": "H33B_DROME", "url": "https://www.uniprot.org/uniprot/C0HL67", "type": "external" } ], "mass": 15328.0, "length": 136, "protein_name": "Histone H3.3B", "gene_name": "His3.3B", "organism": "Fruit fly", "refseq_name": "histone H3.3B, isoform E", "refseq_ac": [ { "id": "NP_001259374", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259374", "type": "external" } ], "gene_names_uniprotkb": "His3.3B; CG8989", "gene_names_refseq": "CG8989; Dmel\\CG8989; H3.3B; H3.3; His 3.3 B; His 3.3B; His3.3B; His3.3; HisH3-3Q; PH3; anon-EST:fe1B6; dH3.3B", "protein_names_uniprotkb": "Histone H3.3B; H3.B", "protein_names_refseq": "CG8989-PE; His3.3B-PE; HistoneH3; anon-fast-evolving-1B6; histone H3-3Q; histone H3.3B, isoform E; histone H3.3; histone variant 3.3; histone variant H3.3", "tax_id": 7227, "disease": "Bryant-Li-Bhoj neurodevelopmental syndrome 1 (Disease Ontology:DOID:0051011); Bryant-Li-Bhoj neurodevelopmental syndrome 2 (Disease Ontology:DOID:0051012)", "pathway": " (dme:Dmel_CG5825); (dme:Dmel_CG8989); (R-DME-212300); (R-DME-2559580); (R-DME-2559582); (R-DME-427359); (R-DME-427413); (R-DME-5578749); (R-DME-5625886); (R-DME-68616); (R-DME-73772); (R-DME-8936459); (R-DME-9018519); (R-DME-9764725); (R-DME-983231); (R-DME-9841922); (R-DME-9843940); (R-DME-9909649); (R-DME-9940951); (R-DME-9943411); (R-DME-9943962)", "pathway_count": 21, "publication_count": 13, "publication_id_list": "10731132;11114889;11266459;11371341;12514098;12537569;12537572;14732680;15371351;1748304;22389435;36930688;7557364", "class_list": "", "function": "Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes and is specifically enriched in modifications associated with active chromatin. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V466;E2QCP0;P06351;P33155;P84249;Q9V3W4", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore;GO:0000786 nucleosome;GO:0005700 polytene chromosome", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0006334 nucleosome assembly;GO:0007080 mitotic metaphase chromosome alignment;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "C0HL67-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05783-1", "uniprot_id": [ { "id": "HMGD_DROME", "url": "https://www.uniprot.org/uniprot/Q05783", "type": "external" } ], "mass": 12416.0, "length": 112, "protein_name": "High mobility group protein D", "gene_name": "HmgD", "organism": "Fruit fly", "refseq_name": "high mobility group protein D, isoform C", "refseq_ac": [ { "id": "NP_001163244", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163244", "type": "external" } ], "gene_names_uniprotkb": "HmgD; CG17950; Dm-HMG-D100; Dmel\\CG17950; Dmel_CG17950; HMG D; HMG-D100; HMG-D; HMG1; HMGD; Hmg-D; anon-EST:Liang-1.9; clone 1.9; dHMG-D; hmg-D; hmgd", "gene_names_refseq": "CG17950; Dm-HMG-D100; Dmel\\CG17950; HMG D; HMG-D100; HMG-D; HMG1; HMGD; Hmg-D; HmgD; anon-EST:Liang-1.9; clone 1.9; dHMG-D; hmg-D; hmgd", "protein_names_uniprotkb": "High mobility group protein D; HMG-D", "protein_names_refseq": "CG17950-PC; HmgD-PC; high mobility group protein D, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17950); (R-DME-140342); (R-DME-163282); (R-DME-9837999)", "pathway_count": 4, "publication_count": 21, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;1373803;16110336;16951084;17372656;17569856;17569867;18327897;25190813;25589440;26109356;26109357;7720717;7922039;8168480;8414994", "class_list": "", "function": "Binds preferentially single-stranded DNA and unwinds double-stranded DNA. Prefers sites containing the sequence 5'-ttg-3'. Facilitates DNA bending. Associated with early embryonic chromatin in the absence of histone H1., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q540Z0;Q9W2D3", "ec_number_list": [], "go_molecular_function": "GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0008301 DNA binding, bending;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q05783-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00449-1", "uniprot_id": [ { "id": "MDR49_DROME", "url": "https://www.uniprot.org/uniprot/Q00449", "type": "external" } ], "mass": 142739.0, "length": 1302, "protein_name": "Multidrug resistance protein homolog 49", "gene_name": "Mdr49", "organism": "Fruit fly", "refseq_name": "multi drug resistance 49, isoform B", "refseq_ac": [ { "id": "NP_001163132", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163132", "type": "external" } ], "gene_names_uniprotkb": "Mdr49; CG3879; Dm5; DmMdr49; Dmel\\CG3879; Dmel_CG3879; MDR49; MDR5; Mes5; mdr49; mrd49", "gene_names_refseq": "CG3879; Dm5; DmMdr49; Dmel\\CG3879; MDR49; MDR5; Mdr49; Mes5; mdr49; mrd49", "protein_names_uniprotkb": "Multidrug resistance protein homolog 49; 7.6.2.2; P-glycoprotein 49", "protein_names_refseq": "CG3879-PB; Mdr49-PB; multi drug resistance 49, isoform B", "tax_id": 7227, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); familial temporal lobe epilepsy 3 (Disease Ontology:DOID:0060750); progressive familial intrahepatic cholestasis 3 (Disease Ontology:DOID:0070223); intrahepatic cholestasis of pregnancy 3 (Disease Ontology:DOID:0070229); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); nasal type extranodal NK/T-cell lymphoma (Disease Ontology:DOID:0080797); inflammatory bowel disease 13 (Disease Ontology:DOID:0110893); osteonecrosis (Disease Ontology:DOID:10159); antisocial personality disorder (Disease Ontology:DOID:10939); familial hyperlipidemia (Disease Ontology:DOID:1168); primary biliary cholangitis (Disease Ontology:DOID:12236); malaria (Disease Ontology:DOID:12365); Behcet's disease (Disease Ontology:DOID:13241); hepatic encephalopathy (Disease Ontology:DOID:13413); cholestasis (Disease Ontology:DOID:13580); cystic fibrosis (Disease Ontology:DOID:1485); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); cannabis dependence (Disease Ontology:DOID:1849); intrahepatic cholestasis (Disease Ontology:DOID:1852); cholecystitis (Disease Ontology:DOID:1949); nephroblastoma (Disease Ontology:DOID:2154); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); cryoglobulinemia (Disease Ontology:DOID:2917); pulmonary tuberculosis (Disease Ontology:DOID:2957); familial Mediterranean fever (Disease Ontology:DOID:2987); invasive ductal carcinoma (Disease Ontology:DOID:3008); high grade glioma (Disease Ontology:DOID:3070); temporal lobe epilepsy (Disease Ontology:DOID:3328); toxic encephalopathy (Disease Ontology:DOID:3602); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); allergic rhinitis (Disease Ontology:DOID:4481); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); chronic myeloid leukemia (Disease Ontology:DOID:8552); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dme:Dmel_CG3879)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;2072901;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 50, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B5RIT2;C1C3C4;Q9V6I6", "ec_number_list": [], "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0008559 ABC-type xenobiotic transporter activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043190 ATP-binding cassette (ABC) transporter complex", "go_biological_process": "GO:0055085 transmembrane transport;GO:0001666 response to hypoxia;GO:0009636 response to toxic substance;GO:0006855 xenobiotic transmembrane transport;GO:0008354 germ cell migration", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q00449-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49869-1", "uniprot_id": [ { "id": "HR38_DROME", "url": "https://www.uniprot.org/uniprot/P49869", "type": "external" } ], "mass": 116992.0, "length": 1073, "protein_name": "Probable nuclear hormone receptor HR38", "gene_name": "Hr38", "organism": "Fruit fly", "refseq_name": "hormone receptor-like in 38, isoform B", "refseq_ac": [ { "id": "NP_477119", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477119", "type": "external" } ], "gene_names_uniprotkb": "Hr38; 38E.3; 38E.7; CG1864; DHR38; Dhr38; Dmel\\CG1864; Dmel_CG1864; HR38; NR4A4; dHR38; dhr38; hr38; l(2)02306", "gene_names_refseq": "38E.3; 38E.7; CG1864; DHR38; Dhr38; Dmel\\CG1864; HR38; Hr38; NR4A4; dHR38; dhr38; hr38; l(2)02306", "protein_names_uniprotkb": "Probable nuclear hormone receptor HR38; Nuclear receptor subfamily 4 group A member 4; dHR38", "protein_names_refseq": "CG1864-PB; Hr38-PB; hormone receptor 38; hormone receptor-like 38; hormone receptor-like in 38, isoform B; hormone receptor-like in 38", "tax_id": 7227, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); Parkinson's disease (Disease Ontology:DOID:14330); epilepsy (Disease Ontology:DOID:1826); extraskeletal myxoid chondrosarcoma (Disease Ontology:DOID:4549); mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783); schizophrenia (Disease Ontology:DOID:5419); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (dme:Dmel_CG1864); (R-DME-198693); (R-DME-383280)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;7479849;7644522;9649534;9704500", "class_list": "", "function": "Binds to NGFI-B response elements. Plays an important role in late stages of epidermal metamorphosis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O18383;Q9VIK4", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008270 zinc ion binding;GO:0046982 protein heterodimerization activity;GO:0035259 nuclear glucocorticoid receptor binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0042335 cuticle development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071376 cellular response to corticotropin-releasing hormone stimulus", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P49869-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0KI33-1", "uniprot_id": [ { "id": "Q0KI33_DROME", "url": "https://www.uniprot.org/uniprot/Q0KI33", "type": "external" } ], "mass": 127851.0, "length": 1142, "protein_name": "3.1.3.-; Spermathreecae, isoform F", "gene_name": "sp3", "organism": "Fruit fly", "refseq_name": "spermathreecae, isoform F", "refseq_ac": [ { "id": "NP_001036740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036740", "type": "external" } ], "gene_names_uniprotkb": "sp3; CG7956; Dmel\\CG7956; Dmel_CG7956; INPP5F", "gene_names_refseq": "CG7956; Dmel\\CG7956; INPP5F; sp3", "protein_names_uniprotkb": "3.1.3.-; Spermathreecae, isoform F", "protein_names_refseq": "CG7956-PF; sp3-PF; spermathreecae, isoform F", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7956); (R-DME-1660516)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64", "type": "external" } ], "go_molecular_function": "GO:0016791 phosphatase activity;GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity", "go_cellular_component": "GO:0005769 early endosome;GO:0045334 clathrin-coated endocytic vesicle", "go_biological_process": "GO:0046856 phosphatidylinositol dephosphorylation;GO:2001135 regulation of endocytic recycling;GO:0035211 spermathecum morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q0KI33-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1JIZ7-1", "uniprot_id": [ { "id": "E1JIZ7_DROME", "url": "https://www.uniprot.org/uniprot/E1JIZ7", "type": "external" } ], "mass": 34926.0, "length": 309, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG42487", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_001163752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163752", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG42487; CG42487; Dmel_CG42487", "gene_names_refseq": "CG42487; Dmel\\CG42487", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG42487-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42487)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "E1JIZ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13217-1", "uniprot_id": [ { "id": "PIPA_DROME", "url": "https://www.uniprot.org/uniprot/P13217", "type": "external" } ], "mass": 124863.0, "length": 1095, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase", "gene_name": "norpA", "organism": "Fruit fly", "refseq_name": "no receptor potential A, isoform D", "refseq_ac": [ { "id": "NP_001014720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014720", "type": "external" } ], "gene_names_uniprotkb": "norpA; CG3620; CdkA; DIP2; Dmel\\CG3620; Dmel_CG3620; MRE18; NORPA; NorpA; PI-PLC; PLC-beta; PLCbeta; PLC; anon-EST:Posey221; nofC; rof; x12; x13; x16; x24", "gene_names_refseq": "CG3620; CdkA; DIP2; Dmel\\CG3620; MRE18; NORPA; NorpA; PI-PLC; PLC-beta; PLCbeta; PLC; anon-EST:Posey221; nofC; norpA; rof; x12; x13; x16; x24", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta; 3.1.4.11; No receptor potential A protein; Phosphoinositide phospholipase C-beta; Phosphoinositide phospholipase C", "protein_names_refseq": "CG3620-PD; No receptor potential A; eye-specific PLC; mRNA-like ncRNA in embryogenesis 18; no receptor potential A, isoform D; no receptor potentials A; no receptor potential; no-receptor potential A; no-receptor-potential A; no-receptor-potential-A; norp A; norpA-PD; phospholipase C-beta; phospholipase C[[beta]]; phospholipase C; phospholipase cbeta; phospholipase-C", "tax_id": 7227, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); retinal disease (Disease Ontology:DOID:5679); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (dme:Dmel_CG3620); (R-DME-112043); (R-DME-1855204); (R-DME-416476)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "10731132;10731138;11500369;12537568;12537572;12537573;12537574;16110336;17569856;17569867;2457447;25589440;25639794;26109356;26109357", "class_list": "", "function": "The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway (PubMed:2457447). Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V3Y2;Q59E70;Q86P93;Q9U4G4;Q9W4K9", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005096 GTPase activator activity;GO:0004629 phospholipase C activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0016028 rhabdomere;GO:0016027 inaD signaling complex", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:0019722 calcium-mediated signaling;GO:0016042 lipid catabolic process;GO:0007601 visual perception;GO:0045494 photoreceptor cell maintenance", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P13217-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13709-1", "uniprot_id": [ { "id": "FSH_DROME", "url": "https://www.uniprot.org/uniprot/P13709", "type": "external" } ], "mass": 205345.0, "length": 2038, "protein_name": "Homeotic protein female sterile", "gene_name": "fs(1)h", "organism": "Fruit fly", "refseq_name": "female sterile (1) homeotic, isoform F", "refseq_ac": [ { "id": "NP_001162699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162699", "type": "external" } ], "gene_names_uniprotkb": "fs(1)h; 26A; Brd4; CG2252; Dmel\\CG2252; Dmel_CG2252; FSH-S; FSH; Fs(1)h-L; Fs(1)hL; Fs(1)hS; Fs(1)h; Fsh; N72; ORE-1; anon-EST:Liang-1.81; anon-EST:fe1G2; clone 1.81; dBRD4; fs(1)1456; fs(1)M16; fs(1)R10.4; fs[1]h; fsh; fst(1)h; l(1)7Da; l(1)G0093; l(1)G0495; rnc", "gene_names_refseq": "Brd4; CG2252; Dmel\\CG2252; FSH-S; FSH; Fs(1)h-L; Fs(1)h/Brd4; Fs(1)hL; Fs(1)hS; Fs(1)h; Fsh; N72; ORE-1; anon-EST:Liang-1.81; anon-EST:fe1G2; clone 1.81; dBRD4; fs(1)1456; fs(1)26/26A; fs(1)M16; fs(1)R10.4; fs(1)h; fs[1]h; fsh; fst(1)h; l(1)7Da; l(1)G0093; l(1)G0495; rnc", "protein_names_uniprotkb": "Homeotic protein female sterile; Fragile-chorion membrane protein", "protein_names_refseq": "CG2252-PF; anon-fast-evolving-1G2; female sterile (1) homeotic, isoform F; female sterile (1) homoeotic; female sterile 1 homeotic; female sterile homeotic; fs(1)h-PF; rancor", "tax_id": 7227, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); Cornelia de Lange syndrome 6 (Disease Ontology:DOID:0060970); spermatogenic failure 21 (Disease Ontology:DOID:0070163); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); nephrocalcinosis (Disease Ontology:DOID:12679); azoospermia (Disease Ontology:DOID:14227); oligospermia (Disease Ontology:DOID:14228); melanoma (Disease Ontology:DOID:1909); colon cancer (Disease Ontology:DOID:219); transitional cell carcinoma (Disease Ontology:DOID:2671); photosensitivity disease (Disease Ontology:DOID:3159); papillary thyroid carcinoma (Disease Ontology:DOID:3969); juvenile myoclonic epilepsy (Disease Ontology:DOID:4890); B-cell lymphoma (Disease Ontology:DOID:707)", "pathway": " (dme:Dmel_CG2252); (R-DME-8951936); (R-DME-9909649)", "pathway_count": 3, "publication_count": 15, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;2567251;26109356;26109357;3031652;33925313", "class_list": "", "function": "Required maternally for proper expression of other homeotic genes involved in pattern formation, such as Ubx., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 14, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4V442;P13710;Q8IRN6;Q9W3L3", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0004674 protein serine/threonine kinase activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0042393 histone binding;GO:0106140 P-TEFb complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016020 membrane;GO:0000785 chromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0048813 dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P13709-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19351-1", "uniprot_id": [ { "id": "TNNT_DROME", "url": "https://www.uniprot.org/uniprot/P19351", "type": "external" } ], "mass": 47448.0, "length": 397, "protein_name": "Troponin T, skeletal muscle", "gene_name": "up", "organism": "Fruit fly", "refseq_name": "upheld, isoform G", "refseq_ac": [ { "id": "NP_001014737", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014737", "type": "external" } ], "gene_names_uniprotkb": "up; BcDNA:LD08591; CG7107; DmTpnT; Dmel\\CG7107; Dmel_CG7107; TNT; Tn-T; TnT; TpnT; Up; cTNT; dro TnT; int; tnT; upheld2; wupB", "gene_names_refseq": "BcDNA:LD08591; CG7107; DmTpnT; Dmel\\CG7107; TNT; Tn-T; TnT; TpnT; Up; cTNT; dro TnT; int; tnT; upheld2; up; wupB", "protein_names_uniprotkb": "Troponin T, skeletal muscle; Protein intended thorax; Protein upheld", "protein_names_refseq": "CG7107-PG; indented thorax; troponin T; troponin-T; troponinT; up-PG; upheld, isoform G; upheld", "tax_id": 7227, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); intrinsic cardiomyopathy (Disease Ontology:DOID:0060036); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); COVID-19 (Disease Ontology:DOID:0080600); nemaline myopathy 5B (Disease Ontology:DOID:0081374); nemaline myopathy 5C (Disease Ontology:DOID:0081375); hypertrophic cardiomyopathy 2 (Disease Ontology:DOID:0110308); dilated cardiomyopathy 1D (Disease Ontology:DOID:0110426); nemaline myopathy 5A (Disease Ontology:DOID:0110936); familial restrictive cardiomyopathy 3 (Disease Ontology:DOID:0111427); distal arthrogryposis type 2B (Disease Ontology:DOID:0111599); distal arthrogryposis type 2B2 (Disease Ontology:DOID:0111601); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); nemaline myopathy (Disease Ontology:DOID:3191); restrictive cardiomyopathy (Disease Ontology:DOID:397); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (dme:Dmel_CG7107)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;19524510;2124273;25589440;26109356;26109357;2852258", "class_list": "", "function": "Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 17, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E1JJP1;E1JJP2;E1JJP3;E4NKN4;F2FB91;Q59E46;Q59E47;Q6T2Y5;Q6T2Y6;Q6T2Y7;Q6T2Y8;Q6T2Y9;Q8SZI3;Q960L9;Q9VYB3;Q9VYB4;Q9VYB5", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005523 tropomyosin binding", "go_cellular_component": "GO:0005865 striated muscle thin filament;GO:0005861 troponin complex", "go_biological_process": "GO:0006936 muscle contraction;GO:0046716 muscle cell cellular homeostasis;GO:0006874 intracellular calcium ion homeostasis;GO:0007005 mitochondrion organization;GO:0045214 sarcomere organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P19351-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28167-1", "uniprot_id": [ { "id": "ZFH2_DROME", "url": "https://www.uniprot.org/uniprot/P28167", "type": "external" } ], "mass": 332019.0, "length": 3005, "protein_name": "Zinc finger protein 2", "gene_name": "zfh2", "organism": "Fruit fly", "refseq_name": "Zn finger homeodomain 2, isoform A", "refseq_ac": [ { "id": "NP_524623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524623", "type": "external" } ], "gene_names_uniprotkb": "zfh2; CG1449; Dmel\\CG1449; Dmel_CG1449; ZFH-2; ZFH2; Zfh-2; Zfh2; zfh-2", "gene_names_refseq": "CG1449; Dmel\\CG1449; ZFH-2; ZFH2; Zfh-2; Zfh2; zfh-2; zfh2", "protein_names_uniprotkb": "Zinc finger protein 2; Zinc finger homeodomain protein 2", "protein_names_refseq": "CG1449-PA; Zn finger homeodomain 2, isoform A; zfh2-PA; zinc finger homeodomain 2; zinc finger homeodomain-2; zn finger homeodomain 2", "tax_id": 7227, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); spinocerebellar ataxia 4 (Disease Ontology:DOID:0050957); Marsili syndrome (Disease Ontology:DOID:0081075); prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); autoimmune hepatitis (Disease Ontology:DOID:2048); mucinous adenocarcinoma (Disease Ontology:DOID:3030); breast carcinoma (Disease Ontology:DOID:3459); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); cervical cancer (Disease Ontology:DOID:4362); tubular adenocarcinoma (Disease Ontology:DOID:4929); hepatocellular carcinoma (Disease Ontology:DOID:684); hepatoblastoma (Disease Ontology:DOID:687); colorectal cancer (Disease Ontology:DOID:9256); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG1449); (R-DME-8941855)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;1680376;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Involved in the development of the embryonic central nervous system., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q95SN9;Q9V4D7", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0007476 imaginal disc-derived wing morphogenesis;GO:0035220 wing disc development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P28167-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24118-1", "uniprot_id": [ { "id": "PIGE_DROME", "url": "https://www.uniprot.org/uniprot/Q24118", "type": "external" } ], "mass": 102899.0, "length": 915, "protein_name": "Protein pigeon", "gene_name": "pigeon", "organism": "Fruit fly", "refseq_name": "pigeon, isoform A", "refseq_ac": [ { "id": "NP_476946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476946", "type": "external" } ], "gene_names_uniprotkb": "pigeon; CG10739; Dmel\\CG10739; Dmel_CG10739; lio; pio", "gene_names_refseq": "CG10739; Dmel\\CG10739; lio; pigeon; pio", "protein_names_uniprotkb": "Protein pigeon; Protein linotte", "protein_names_refseq": "CG10739-PA; linotte; lionette; pigeon, isoform A; pigeon-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10739)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;7576632", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VIY7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005802 trans-Golgi network", "go_biological_process": "GO:1902004 positive regulation of amyloid-beta formation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q24118-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16905-1", "uniprot_id": [ { "id": "KAPR1_DROME", "url": "https://www.uniprot.org/uniprot/P16905", "type": "external" } ], "mass": 42239.0, "length": 376, "protein_name": "cAMP-dependent protein kinase type I regulatory subunit", "gene_name": "Pka-R1", "organism": "Fruit fly", "refseq_name": "protein kinase, cAMP-dependent, regulatory subunit type 1, isoform L", "refseq_ac": [ { "id": "NP_001014593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014593", "type": "external" } ], "gene_names_uniprotkb": "Pka-R1; 18304; CG12452; CG18677; CG3263; CG42341; CdkR; DRI; Dmel\\CG42341; Dmel_CG42341; PKA R1; PKA-R1; PKA-RI; PKARI; PKAR; PKAi; PKAr; PKA; PKa-R1; Pka-RI; PkaR; RI; dPKA-RI; dr[[1]]; pKA; pkA; pka-R1", "gene_names_refseq": "18304; CG12452; CG18677; CG3263; CG42341; CdkR; DRI; Dmel\\CG42341; PKA R1; PKA-R1; PKA-RI; PKARI; PKAR; PKAi; PKAr; PKA; PKa-R1; Pka-R1; Pka-RI; PkaR; RI; dPKA-RI; dr[[1]]; pKA; pkA; pka-R1", "protein_names_uniprotkb": "cAMP-dependent protein kinase type I regulatory subunit; DRI class I to class IV", "protein_names_refseq": "CG42341-PL; Pka-R1-PL; cAMP-dependent protein kinase 1; cAMP-dependent protein kinase R1; cAMP-dependent protein kinase; protein kinase A; protein kinase, cAMP-dependent, regulatory subunit type 1, isoform L; regulatory subunit of PKA; regulatory subunit of protein kinase A; type I regulatory subunit of cAMP-dependent protein kinase", "tax_id": 7227, "disease": "Carney complex (Disease Ontology:DOID:0050471); primary pigmented nodular adrenocortical disease (Disease Ontology:DOID:0060280); primary pigmented nodular adrenocortical disease 1 (Disease Ontology:DOID:0070546); acrodysostosis (Disease Ontology:DOID:14669); follicular thyroid carcinoma (Disease Ontology:DOID:3962)", "pathway": " (dme:Dmel_CG42341); (R-DME-163615); (R-DME-164378); (R-DME-180024); (R-DME-432040); (R-DME-442720); (R-DME-5610787); (R-DME-9634597); (R-DME-983231); (R-DME-9856530)", "pathway_count": 10, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;3215511", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V272;A4V277;Q59E10;Q8IGP3;Q8IPU2;Q8MR47;Q95TK7;Q9VPA6", "ec_number_list": [], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0008603 cAMP-dependent protein kinase regulator activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0005952 cAMP-dependent protein kinase complex", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0007015 actin filament organization;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007274 neuromuscular synaptic transmission;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P16905-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23654-1", "uniprot_id": [ { "id": "NRT_DROME", "url": "https://www.uniprot.org/uniprot/P23654", "type": "external" } ], "mass": 92776.0, "length": 846, "protein_name": "Neurotactin", "gene_name": "Nrt", "organism": "Fruit fly", "refseq_name": "neurotactin, isoform C", "refseq_ac": [ { "id": "NP_001189121", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189121", "type": "external" } ], "gene_names_uniprotkb": "Nrt; BP106; BcDNA:LD22004; CG9704; DAB; Dab; Dmel\\CG9704; Dmel_CG9704; MabBP106; NRT BP106; NRT; NT; Neur; Nrt BP106; dab; l(3)73Be; neu; nrt", "gene_names_refseq": "BP106; BcDNA:LD22004; CG9704; DAB; Dab; Dmel\\CG9704; MabBP106; NRT BP106; NRT; NT; Neur; Nrt BP106; Nrt; dab; l(3)73Be; neu; nrt", "protein_names_uniprotkb": "Neurotactin", "protein_names_refseq": "CG9704-PC; Nrt-PC; disabled; neurotactin, isoform C; neurotactin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9704); (R-DME-2022377); (R-DME-211945); (R-DME-5578768); (R-DME-8964038); (R-DME-9749641)", "pathway_count": 6, "publication_count": 16, "publication_id_list": "10731132;10731138;12537568;12537572;12537573;12537574;16110336;17569856;17569867;18327897;2100266;2120047;2120048;25589440;26109356;26109357", "class_list": "", "function": "May mediate or modulate cell adhesion between embryonic cells during development., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 17, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A4V209;Q9V3F0", "ec_number_list": [], "go_molecular_function": "GO:0004895 cell adhesion receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0007409 axonogenesis;GO:0007417 central nervous system development;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007413 axonal fasciculation;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P23654-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M9MS40-1", "uniprot_id": [ { "id": "M9MS40_DROME", "url": "https://www.uniprot.org/uniprot/M9MS40", "type": "external" } ], "mass": 341431.0, "length": 3282, "protein_name": "histone acetyltransferase", "gene_name": "nej", "organism": "Fruit fly", "refseq_name": "nejire, isoform C", "refseq_ac": [ { "id": "NP_001188575", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188575", "type": "external" } ], "gene_names_uniprotkb": "nej; CBP_; CBP; CG15319; CG15321; Cbp; Crbp; Dmel\\CG15319; Dmel_CG15319; Nejire; Nej; P300; anon-WO0147981.11; anon-WO03040301.89; cbp; dCBP; dKAT3; dmCBP; l(1)G0112; l(1)G0350; l(1)G0470; nej CBP; p300", "gene_names_refseq": "CBP/p300; CBP_; CBP; CG15319; CG15321; Cbp; Crbp; Dmel\\CG15319; Nejire; Nej; P300; anon-WO0147981.11; anon-WO03040301.89; cbp; dCBP; dKAT3; dmCBP; l(1)G0112; l(1)G0350; l(1)G0470; nej CBP; nej; p300/CBP; p300", "protein_names_uniprotkb": "histone acetyltransferase; 2.3.1.48", "protein_names_refseq": "CBP histone acetyltransferase; CBP/Nejire; CG15319-PC; CREB binding protein; CREB-binding protein; cyclic AMP response element binding protein; drosophila CREB-binding protein; lethal (1) G0112; lethal (1) G0350; lethal (1) G0470; nej-PC; nejire, isoform C; nejire", "tax_id": 7227, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); cardiomyopathy (Disease Ontology:DOID:0050700); myelodysplastic syndrome (Disease Ontology:DOID:0050908); autism spectrum disorder (Disease Ontology:DOID:0060041); cardiac arrest (Disease Ontology:DOID:0060319); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); heart disease (Disease Ontology:DOID:114); Huntington's disease (Disease Ontology:DOID:12858); alcohol use disorder (Disease Ontology:DOID:1574); Rubinstein-Taybi syndrome (Disease Ontology:DOID:1933); transient cerebral ischemia (Disease Ontology:DOID:224); membranoproliferative glomerulonephritis (Disease Ontology:DOID:2920); glomerulonephritis (Disease Ontology:DOID:2921); breast carcinoma (Disease Ontology:DOID:3459); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); clear cell renal cell carcinoma (Disease Ontology:DOID:4467); congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684); diabetic retinopathy (Disease Ontology:DOID:8947); systemic lupus erythematosus (Disease Ontology:DOID:9074); acute myeloid leukemia (Disease Ontology:DOID:9119); colorectal cancer (Disease Ontology:DOID:9256); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dme:Dmel_CG15319); (R-DME-1234158); (R-DME-201722); (R-DME-3214847); (R-DME-400206); (R-DME-5621575); (R-DME-6804758); (R-DME-6811555); (R-DME-8936459); (R-DME-8939243); (R-DME-8939246); (R-DME-8941858); (R-DME-8951936); (R-DME-9018519); (R-DME-9029569); (R-DME-9617629); (R-DME-9701898); (R-DME-9707564); (R-DME-9759194); (R-DME-9841922); (R-DME-9856649)", "pathway_count": 21, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 26, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "2.3.1.311", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.311", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.370", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.370", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0031490 chromatin DNA binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0004402 histone acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0035097 histone methyltransferase complex;GO:0098793 presynapse", "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0045880 positive regulation of smoothened signaling pathway;GO:0048749 compound eye development;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "M9MS40-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M9NDR1-1", "uniprot_id": [ { "id": "M9NDR1_DROME", "url": "https://www.uniprot.org/uniprot/M9NDR1", "type": "external" } ], "mass": 33377.0, "length": 286, "protein_name": "BTB domain-containing protein", "gene_name": "Dmel\\CG43120", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_001246754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246754", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG43120; CG43120; Dmel_CG43120", "gene_names_refseq": "CG43120; Dmel\\CG43120", "protein_names_uniprotkb": "BTB domain-containing protein", "protein_names_refseq": "CG43120-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG43120); (R-DME-8951664); (R-DME-983168)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "M9NDR1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30189-1", "uniprot_id": [ { "id": "TOP1_DROME", "url": "https://www.uniprot.org/uniprot/P30189", "type": "external" } ], "mass": 111903.0, "length": 974, "protein_name": "DNA topoisomerase 1", "gene_name": "Top1", "organism": "Fruit fly", "refseq_name": "topoisomerase 1, isoform C", "refseq_ac": [ { "id": "NP_001014742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014742", "type": "external" } ], "gene_names_uniprotkb": "Top1; CG6146; Dmel\\CG6146; Dmel_CG6146; ND432; TOP1; TopI; Topo I; Topo1; TopoI; dTopoI; l(1)G0134; l(1)G0201; l(1)G0229; l(1)G0278; l(1)top1; top1; topo I; topoI; topoisomerase I", "gene_names_refseq": "CG6146; Dmel\\CG6146; ND432; TOP1; Top1; TopI; Topo I; Topo1; TopoI; dTopoI; l(1)G0134; l(1)G0201; l(1)G0229; l(1)G0278; l(1)top1; top1; topo I; topoI; topoisomerase I", "protein_names_uniprotkb": "DNA topoisomerase 1; 5.6.2.1; DNA topoisomerase I", "protein_names_refseq": "CG6146-PC; Top 1; Top1-PC; topoisomerase 1, isoform C; topoisomerase I; topoisomerase1; type I topoisomerase", "tax_id": 7227, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dme:Dmel_CG6146)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;10885744;12537568;12537572;12537573;12537574;1335568;14871887;16110336;17569856;17569867;18327897;25589440;26109356;26109357;8769417", "class_list": "", "function": "Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex (By similarity). Introduces a single-strand break via transesterification at a target site in duplex DNA (By similarity). The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand (By similarity). The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils (By similarity). Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q494M1;Q9VXW6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity;GO:0003916 DNA topoisomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000785 chromatin", "go_biological_process": "GO:0007059 chromosome segregation;GO:0006260 DNA replication;GO:0030261 chromosome condensation;GO:0048477 oogenesis;GO:0006265 DNA topological change", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P30189-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0KHQ5-1", "uniprot_id": [ { "id": "TAO_DROME", "url": "https://www.uniprot.org/uniprot/Q0KHQ5", "type": "external" } ], "mass": 118298.0, "length": 1039, "protein_name": "Serine/threonine-protein kinase Tao", "gene_name": "Tao", "organism": "Fruit fly", "refseq_name": "Tao, isoform F", "refseq_ac": [ { "id": "NP_001188672", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188672", "type": "external" } ], "gene_names_uniprotkb": "Tao; AAF48973; CG14217; Dmel\\CG14217; Dmel_CG14217; MARKK; TAO-1; TAO1; Tao-1; Tao1; dTao-1; tao-1; tao1; tao", "gene_names_refseq": "AAF48973; CG14217; Dmel\\CG14217; MARKK; TAO-1; TAO1; Tao-1; Tao1; Tao; dTao-1; tao-1; tao1; tao", "protein_names_uniprotkb": "Serine/threonine-protein kinase Tao; 2.7.11.1", "protein_names_refseq": "CG14217-PF; Tao, isoform F; Tao-1; Tao-PF; Tao1", "tax_id": 7227, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); chromosome 16p11.2 deletion syndrome, 593-kb (Disease Ontology:DOID:0070515); cancer (Disease Ontology:DOID:162); central nervous system disease (Disease Ontology:DOID:331)", "pathway": " (dme:Dmel_CG14217)", "pathway_count": 1, "publication_count": 22, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17449640;17569856;17569867;20647372;21248138;22075147;22075148;23227189;23266957;25160975;25589440;25589578;26109356;26109357;26954546", "class_list": "", "function": "Induces in vitro expression of actin-dependent filopodia-like cytoplasmic protrusions which firmly attach to the substrate. Antagonizes the activity of isoform D., [UniProtKB, PubMed]; Induces in vitro expression of large, highly dynamic, microtubule-dependent lamellopodia-like cytoplasmic expansions which constantly probe the environment., [UniProtKB, PubMed]; Serine/threonine-protein kinase which regulates the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (hpo), in complex with its regulatory protein Salvador (sav), phosphorylates and activates Warts (wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (yki) oncoprotein (PubMed:22075147, PubMed:22075148). In imaginal cells, phosphorylates and activates hpo and leads to repression of yki (PubMed:22075147, PubMed:22075148). In the midgut, negatively regulates the proliferation of intestinal stem cells through the Hippo/SWH pathway (PubMed:25160975). Independent of the hippo/SWH pathway, regulates epithelial morphogenesis in follicle cells by promoting the endocytosis of Fas2 and reducing lateral adhesion between epithelial cells which, in turn, permits shrinking of the lateral membrane and initiates morphogenesis of the squamous epithelium (PubMed:23266957). Required for the development of both the mushroom body and the ellipsoid body in the brain and may act as a negative regulator of the par-1 kinase (PubMed:21248138). Negatively regulates the JNK pathway which increases sensitivity to ethanol exposure (PubMed:23227189). Plays a role in the control of cell shape by negatively regulating the growth of microtubule plus-ends as they contact the actin-rich cell cortex (PubMed:20647372). Required for the induction of apoptosis in pole cells by promoting expression of skl which enhances activity of the apoptosis activator hid (PubMed:17449640)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8T093", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0046621 negative regulation of organ growth;GO:0035094 response to nicotine;GO:0045471 response to ethanol;GO:0046330 positive regulation of JNK cascade;GO:0001894 tissue homeostasis", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "Q0KHQ5-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M9NE34-1", "uniprot_id": [ { "id": "M9NE34_DROME", "url": "https://www.uniprot.org/uniprot/M9NE34", "type": "external" } ], "mass": 11536.0, "length": 103, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG43293", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": [ { "id": "NP_001246644", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246644", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG43293; CG43293; Dmel_CG43293", "gene_names_refseq": "CG43293; Dmel\\CG43293", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG43293-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG43293)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "M9NE34-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10180-1", "uniprot_id": [ { "id": "CUT_DROME", "url": "https://www.uniprot.org/uniprot/P10180", "type": "external" } ], "mass": 233629.0, "length": 2175, "protein_name": "Homeobox protein cut", "gene_name": "ct", "organism": "Fruit fly", "refseq_name": "cut, isoform A", "refseq_ac": [ { "id": "NP_524764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524764", "type": "external" } ], "gene_names_uniprotkb": "ct; BcDNA:GH10590; CG11387; CT; CUT; Ct; Cut; Dmel\\CG11387; Dmel_CG11387; kf; l(1)7Ba; l(1)7Bb; l(1)VE614", "gene_names_refseq": "BcDNA:GH10590; CG11387; CT; CUT; Ct; Cut; Dmel\\CG11387; ct; kf; l(1)7Ba; l(1)7Bb; l(1)VE614", "protein_names_uniprotkb": "Homeobox protein cut", "protein_names_refseq": "CG11387-PA; Cut; ct-PA; cut, isoform A; kinked-femur", "tax_id": 7227, "disease": "developmental and epileptic encephalopathy 67 (Disease Ontology:DOID:0112203); stomach cancer (Disease Ontology:DOID:10534); cancer (Disease Ontology:DOID:162); hematologic cancer (Disease Ontology:DOID:2531); insulinoma (Disease Ontology:DOID:3892); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dme:Dmel_CG11387)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;2897632", "class_list": "", "function": "Regulator of cell fate decisions in multiple lineages. Specifically, functions as a determination factor that specifies sensory organ identity in precursor cells. Probably also involved in cell type specification of Malpighian tubules. In absence of cut gene external sensory organs are transformed into chordotonal organs., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9W3Q6", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0140059 dendrite arborization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P10180-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M9PHQ2-1", "uniprot_id": [ { "id": "M9PHQ2_DROME", "url": "https://www.uniprot.org/uniprot/M9PHQ2", "type": "external" } ], "mass": 136171.0, "length": 1269, "protein_name": "histone deacetylase", "gene_name": "HDAC4", "organism": "Fruit fly", "refseq_name": "histone deacetylase 4, isoform G", "refseq_ac": [ { "id": "NP_001259507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259507", "type": "external" } ], "gene_names_uniprotkb": "HDAC4; CG1770; DHDAC4; Dmel\\CG1770; Dmel_CG1770; GC1770; HDAC4a; HDAC; Hdac4; dHDAC4; dmHDA405; hdac4", "gene_names_refseq": "CG1770; DHDAC4; Dmel\\CG1770; GC1770; HDAC4a; HDAC4; HDAC; Hdac4; dHDAC4; dmHDA405; hdac4", "protein_names_uniprotkb": "histone deacetylase; 3.5.1.98", "protein_names_refseq": "CG1770-PG; HDAC4-PG; histone deacetylase 4, isoform G; histone deacetylase 4", "tax_id": 7227, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); stroke (Disease Ontology:DOID:0051061); ataxia telangiectasia (Disease Ontology:DOID:12704); depressive disorder (Disease Ontology:DOID:1596); impotence (Disease Ontology:DOID:1875); transient cerebral ischemia (Disease Ontology:DOID:224); acute kidney failure (Disease Ontology:DOID:3021); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); aortic aneurysm (Disease Ontology:DOID:3627); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); retinal degeneration (Disease Ontology:DOID:8466); eating disorder (Disease Ontology:DOID:8670); colorectal cancer (Disease Ontology:DOID:9256); alopecia areata (Disease Ontology:DOID:986); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG1770); (R-DME-350054); (R-DME-4090294); (R-DME-4551638); (R-DME-8951936)", "pathway_count": 5, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004407 histone deacetylase activity;GO:0141221 histone deacetylase activity, hydrolytic mechanism;GO:0019789 SUMO transferase activity;GO:0033558 protein lysine deacetylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007613 memory;GO:0006355 regulation of DNA-templated transcription;GO:0007616 long-term memory", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "M9PHQ2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54357-1", "uniprot_id": [ { "id": "MLC2_DROME", "url": "https://www.uniprot.org/uniprot/P54357", "type": "external" } ], "mass": 16613.0, "length": 147, "protein_name": "Myosin-2 essential light chain", "gene_name": "Mlc-c", "organism": "Fruit fly", "refseq_name": "myosin light chain cytoplasmic, isoform A", "refseq_ac": [ { "id": "NP_511049", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_511049", "type": "external" } ], "gene_names_uniprotkb": "Mlc-c; CG3201; DmMLC_C; Dmel\\CG3201; Dmel_CG3201; ELC1; ELC; MyoII; mlc-c; nmELC", "gene_names_refseq": "CG3201; DmMLC_C; Dmel\\CG3201; ELC1; ELC; Mlc-c; MyoII; mlc-c; nmELC", "protein_names_uniprotkb": "Myosin-2 essential light chain; Myosin II essential light chain; Non-muscle myosin essential light chain", "protein_names_refseq": "CG3201-PA; Mlc-c-PA; Myosin-II; alkali light chain of non-muscle myosin-II; essential light chain-cytoplasmic; essential myosin light chain-cytoplasmic; myosin II; myosin light chain cytoplasmic, isoform A; myosin light chain-cytoplasmic; non-muscle myosin II; non-muscle myosin-II", "tax_id": 7227, "disease": "familial atrial fibrillation (Disease Ontology:DOID:0050650); cardiomyopathy (Disease Ontology:DOID:0050700); congenital myopathy 14 (Disease Ontology:DOID:0081346); hypertrophic cardiomyopathy 8 (Disease Ontology:DOID:0110314); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (dme:Dmel_CG3201); (R-DME-350480); (R-DME-445355)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "10570971;10731132;11301004;11874917;12537568;12537572;12537573;12537574;15269282;16110336;17372656;17569856;17569867;25589440;26109356;26109357;8567936", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C1C594;Q9W4A8", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0017022 myosin binding;GO:0032036 myosin heavy chain binding", "go_cellular_component": "GO:0031475 myosin V complex;GO:0005829 cytosol;GO:0031477 myosin VII complex;GO:0016460 myosin II complex;GO:0031476 myosin VI complex", "go_biological_process": "GO:0030048 actin filament-based movement", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P54357-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M9NEZ1-1", "uniprot_id": [ { "id": "M9NEZ1_DROME", "url": "https://www.uniprot.org/uniprot/M9NEZ1", "type": "external" } ], "mass": 30188.0, "length": 267, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG45066", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_001246586", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246586", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG45066; CG14955; CG45066; Dmel_CG45066", "gene_names_refseq": "CG14955; CG45066; Dmel\\CG45066", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG45066-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG45066)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "M9NEZ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24567-1", "uniprot_id": [ { "id": "NETA_DROME", "url": "https://www.uniprot.org/uniprot/Q24567", "type": "external" } ], "mass": 80366.0, "length": 726, "protein_name": "Netrin-A", "gene_name": "NetA", "organism": "Fruit fly", "refseq_name": "Netrin-A, isoform B", "refseq_ac": [ { "id": "NP_001245667", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245667", "type": "external" } ], "gene_names_uniprotkb": "NetA; CG18657; CT27014; Dmel\\CG18657; Dmel_CG18657; NetrinA; Netrin; netA; netrin A; netrin; net", "gene_names_refseq": "CG18657; CT27014; Dmel\\CG18657; NetA; NetrinA; Netrin; netA; netrin A; netrin; net", "protein_names_uniprotkb": "Netrin-A", "protein_names_refseq": "CG18657-PB; D-netrin-A; D-netrin; NetA-PB; Netrin-A, isoform B; NetrinA; netrin A", "tax_id": 7227, "disease": "mirror movements 4 (Disease Ontology:DOID:0070638)", "pathway": " (dme:Dmel_CG18657)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8780645;8780646", "class_list": "", "function": "Netrins control guidance of CNS commissural axons at the midline and peripheral motor axons to their target muscles., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q7JXY0;Q94528;Q9VY25", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0044295 axonal growth cone;GO:0005576 extracellular region", "go_biological_process": "GO:0048749 compound eye development;GO:0016358 dendrite development;GO:0009887 animal organ morphogenesis;GO:0007411 axon guidance;GO:0009888 tissue development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q24567-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46150-1", "uniprot_id": [ { "id": "MOEH_DROME", "url": "https://www.uniprot.org/uniprot/P46150", "type": "external" } ], "mass": 68141.0, "length": 578, "protein_name": "Moesin/ezrin/radixin homolog 1", "gene_name": "Moe", "organism": "Fruit fly", "refseq_name": "moesin, isoform L", "refseq_ac": [ { "id": "NP_001245584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245584", "type": "external" } ], "gene_names_uniprotkb": "Moe; CG10701; D17; DMoe; Dmel\\CG10701; Dmel_CG10701; Dmoe; EMR1; ERM; Emr1; GMA; Moes; anon-WO03040301.155; anon-WO03040301.157; anon-WO03040301.159; anon-WO03040301.161; dMoe; gma; l(1)G0067; l(1)G0323; l(1)G0404; l(1)G0415; moesin; moe; p-Moesin", "gene_names_refseq": "CG10701; D17; DMoe; Dmel\\CG10701; Dmoe; EMR1; ERM; Emr1; GMA; Moes; Moe; anon-WO03040301.155; anon-WO03040301.157; anon-WO03040301.159; anon-WO03040301.161; dMoe; gma; l(1)G0067; l(1)G0323; l(1)G0404; l(1)G0415; moesin/ezrin/radixin homolog mRNA; moesin; moe; p-Moesin", "protein_names_uniprotkb": "Moesin/ezrin/radixin homolog 1; Ezrin-moesin-radixin 1; Moesin; Protein D17; dMoesin", "protein_names_refseq": "CG10701-PL; Ezrin-Radixin-Moesin; Ezrin-moesin-radixin-1; Moe-PL; Moesin-like; dmoesin; moesin, isoform L", "tax_id": 7227, "disease": "autosomal recessive nonsyndromic deafness 24 (Disease Ontology:DOID:0110482); immunodeficiency 50 (Disease Ontology:DOID:0112001); primary biliary cholangitis (Disease Ontology:DOID:12236); Dubin-Johnson syndrome (Disease Ontology:DOID:12308)", "pathway": " (dme:Dmel_CG10701); (R-DME-373752); (R-DME-437239)", "pathway_count": 3, "publication_count": 22, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;16216927;17569856;17569867;18283112;18948416;20237161;23544124;24768049;25061859;25589440;26109356;26109357;28554770;8183953;8666669", "class_list": "", "function": "Involved in connections of major cytoskeletal structures to the plasma membrane (PubMed:8666669). Together with wgn, involved in control of axon targeting of R8 and R2-R5 photoreceptors, independent of egr (PubMed:23544124). In the nucleus, recruited to sites of active transcription by RNA polymerase II where it has a role in nuclear mRNA export together with the mRNA export factor PCID2 and other messenger ribonucleoprotein (mRNP) particles (PubMed:28554770)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V458;P91930;Q24053;Q24435;Q7KVS6;Q7KVS7;Q9W3B4;Q9W3B5;Q9W3B6;Q9W3B7", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0098592 cytoplasmic side of apical plasma membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:1902846 positive regulation of mitotic spindle elongation;GO:1902966 positive regulation of protein localization to early endosome;GO:1902115 regulation of organelle assembly;GO:0008284 positive regulation of cell population proliferation;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P46150-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54350-1", "uniprot_id": [ { "id": "WEE1_DROME", "url": "https://www.uniprot.org/uniprot/P54350", "type": "external" } ], "mass": 68809.0, "length": 609, "protein_name": "Wee1-like protein kinase", "gene_name": "Wee1", "organism": "Fruit fly", "refseq_name": "Wee1 kinase, isoform B", "refseq_ac": [ { "id": "NP_001260167", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260167", "type": "external" } ], "gene_names_uniprotkb": "Wee1; CG4488; Dmel\\CG4488; Dmel_CG4488; Dwee1; Dwee; WEE1; Wee 1; Wee; dWee1; dwee1; wee1; wee", "gene_names_refseq": "CG4488; Dmel\\CG4488; Dwee1; Dwee; WEE1; Wee 1; Wee1; Wee; dWee1; dwee1; wee1; wee", "protein_names_uniprotkb": "Wee1-like protein kinase; 2.7.10.2; Dwee1", "protein_names_refseq": "CG4488-PB; Wee1 kinase, isoform B; Wee1 ortholog; Wee1-PB; wee", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4488); (R-DME-156711); (R-DME-69202); (R-DME-69273); (R-DME-69478); (R-DME-69656); (R-DME-75035)", "pathway_count": 7, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15581871;16110336;17569856;17569867;18327897;25589440;26109356;26109357;8573790", "class_list": "", "function": "Acts as a negative regulator of entry into mitosis (G2 to M transition) (PubMed:15581871, PubMed:8573790). This kinase specifically phosphorylates and inactivates cyclin B1-complexed CDC2 (PubMed:15581871, PubMed:8573790)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VM70", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0051225 spindle assembly;GO:0010972 negative regulation of G2/M transition of mitotic cell cycle;GO:0051642 centrosome localization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P54350-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82295-1", "uniprot_id": [ { "id": "PROML_DROME", "url": "https://www.uniprot.org/uniprot/P82295", "type": "external" } ], "mass": 115106.0, "length": 1013, "protein_name": "Prominin-like protein", "gene_name": "promL", "organism": "Fruit fly", "refseq_name": "prominin-like, isoform E", "refseq_ac": [ { "id": "NP_001261351", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261351", "type": "external" } ], "gene_names_uniprotkb": "promL; CG7740; Dmel\\CG7740; Dmel_CG7740; PromL; bs29e02.y1; prominin-like", "gene_names_refseq": "CG7740; Dmel\\CG7740; PromL; bs29e02.y1; promL", "protein_names_uniprotkb": "Prominin-like protein", "protein_names_refseq": "CG7740-PE; Prominin-like; promL-PE; prominin-like protein; prominin-like, isoform E", "tax_id": 7227, "disease": "retinal macular dystrophy 2 (Disease Ontology:DOID:0070517); retinitis pigmentosa 41 (Disease Ontology:DOID:0110376); cone-rod dystrophy 12 (Disease Ontology:DOID:0111019); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (dme:Dmel_CG7740)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;19349973;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A4V1D5;A8WHI2;Q95RK1;Q9VZV0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0016324 apical plasma membrane;GO:0005902 microvillus;GO:0071914 prominosome;GO:0016020 membrane", "go_biological_process": "GO:0032528 microvillus organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P82295-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02828-1", "uniprot_id": [ { "id": "HSP83_DROME", "url": "https://www.uniprot.org/uniprot/P02828", "type": "external" } ], "mass": 81865.0, "length": 717, "protein_name": "Heat shock protein 83", "gene_name": "Hsp83", "organism": "Fruit fly", "refseq_name": "heat shock protein 83, isoform B", "refseq_ac": [ { "id": "NP_001261362", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261362", "type": "external" } ], "gene_names_uniprotkb": "Hsp83; 143198_at; 4C; 83K HSP; 83; CG1242; DMHSP82; DmHsp83; Dmel\\CG1242; Dmel_CG1242; E(sev)3A; E(sina)2; HSP82; HSP83; HSP90A1; HSP90; Hsp82; Hsp90; ORF1; P02828; Su(Raf)3A; anon-EST:Liang-2.53; anon-WO0068693; anon-WO0140519.209; clone 2.53; dHsp90; hsp82; hsp83; hsp84; hsp90; l(3)j5C2; ms(3)08445; stc", "gene_names_refseq": "143198_at; 83K HSP; 83; CG1242; DMHSP82; DmHsp83; Dmel\\CG1242; E(sev)3A; E(sina)2; HSP82; HSP83; HSP90A1; HSP90; Hsp82; Hsp83; Hsp90; ORF1; P02828; Su(Raf)3A; anon-EST:Liang-2.53; anon-WO0068693; anon-WO0140519.209; clone 2.53; dHsp90; en(lz)3C/4C; hsp82; hsp83; hsp84; hsp90; l(3)j5C2; ms(3)08445; stc", "protein_names_uniprotkb": "Heat shock protein 83; HSP 82", "protein_names_refseq": "CG1242-PB; Hsp83-PB; enhancer of seven in absentia 2; enhancer of sevenless 3A; heat shock protein 83, isoform B; heat shock protein 83; heat-shock protein 90 kDa; hsp83; scratch", "tax_id": 7227, "disease": "withdrawal disorder (Disease Ontology:DOID:0060001); traumatic brain injury (Disease Ontology:DOID:0081292); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); varicocele (Disease Ontology:DOID:12337); cancer (Disease Ontology:DOID:162); colon cancer (Disease Ontology:DOID:219); multiple sclerosis (Disease Ontology:DOID:2377); pulmonary fibrosis (Disease Ontology:DOID:3770); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); pancreatitis (Disease Ontology:DOID:4989); rheumatoid arthritis (Disease Ontology:DOID:7148); muscular atrophy (Disease Ontology:DOID:767)", "pathway": " (dme:Dmel_CG1242); (R-DME-1227986); (R-DME-1474151); (R-DME-2029482); (R-DME-203615); (R-DME-3371497); (R-DME-3371511); (R-DME-3371568); (R-DME-3371571); (R-DME-399954); (R-DME-5218920); (R-DME-6798695); (R-DME-8863795); (R-DME-8937144); (R-DME-8939211); (R-DME-9009391); (R-DME-9013418); (R-DME-9018519); (R-DME-9652282)", "pathway_count": 19, "publication_count": 24, "publication_id_list": "10731132;11493638;12537568;12537569;12537572;12537573;12537574;15952742;16110336;17372656;17569856;17569867;18327897;18344983;21186352;22902557;23509070;2426456;25589440;26109356;26109357;27979731;6314271;8978045", "class_list": "", "function": "Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction (PubMed:18344983, PubMed:21186352, PubMed:22902557). Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation. Required for piRNA biogenesis by facilitating loading of piRNAs into PIWI proteins (PubMed:21186352, PubMed:22902557)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P92174;P92202;Q9VZT3", "ec_number_list": [], "go_molecular_function": "GO:0030911 TPR domain binding;GO:0005158 insulin receptor binding;GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0070922 RISC complex assembly;GO:0097753 membrane bending;GO:0045187 regulation of circadian sleep/wake cycle, sleep;GO:0008285 negative regulation of cell population proliferation;GO:0034605 cellular response to heat", "synthesized_glycan_count": 0, "hit_score": 2.7, "record_id": "P02828-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VPQ6-1", "uniprot_id": [ { "id": "USH_DROME", "url": "https://www.uniprot.org/uniprot/Q9VPQ6", "type": "external" } ], "mass": 124533.0, "length": 1191, "protein_name": "Zinc finger protein ush", "gene_name": "ush", "organism": "Fruit fly", "refseq_name": "u-shaped, isoform A", "refseq_ac": [ { "id": "NP_476780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476780", "type": "external" } ], "gene_names_uniprotkb": "ush; CG2762; Dmel\\CG2762; Dmel_CG2762; FOG; USH; Ush; ZFPM2; dFOG; l(2)19; u-sh; ushaped", "gene_names_refseq": "CG2762; Dmel\\CG2762; FOG; USH; Ush; ZFPM2; dFOG; l(2)19; u-sh; ushaped; ush", "protein_names_uniprotkb": "Zinc finger protein ush; Protein U-shaped", "protein_names_refseq": "CG2762-PA; U-shaped; drosophila friend of GATA; u-shaped, isoform A; ush-PA; ushaped", "tax_id": 7227, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); tricuspid atresia (Disease Ontology:DOID:0080169); 46,XY sex reversal 9 (Disease Ontology:DOID:0111770); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); tetralogy of Fallot (Disease Ontology:DOID:6419)", "pathway": " (dme:Dmel_CG2762); (R-DME-8936459); (R-DME-983231)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "10329627;10731132;10861002;11080638;11404479;12110675;12374748;12537568;12537572;12537573;12537574;12782269;16110336;17569856;17569867;18327897;25589440;26109356;26109357;9367989;9367990", "class_list": "", "function": "Transcription regulator that modulates expression mediated by transcription factors of the GATA family such as pnr and srp. Represses transcription of proneural achaete-scute complex (AS-C), which is usually activated by pnr. Involved in cardiogenesis, blood, and eye development. During hematopoiesis, it is required to restrict the number of crystal cells, probably via its interaction with the isoform SrpNC of srp. Negatively regulates expression of sr. Probably acts by interacting with the GATA-type zinc finger of proteins such as pnr and srp, possibly antagonizing the interaction between the GATA-type zinc finger and some cofactor., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "O18414;Q6AWH0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0001217 DNA-binding transcription repressor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0048749 compound eye development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9VPQ6-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37276-1", "uniprot_id": [ { "id": "DYHC_DROME", "url": "https://www.uniprot.org/uniprot/P37276", "type": "external" } ], "mass": 530184.0, "length": 4639, "protein_name": "Dynein heavy chain, cytoplasmic", "gene_name": "Dhc64C", "organism": "Fruit fly", "refseq_name": "dynein heavy chain 64C, isoform A", "refseq_ac": [ { "id": "NP_523929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523929", "type": "external" } ], "gene_names_uniprotkb": "Dhc64C; CD; CG7507; Cdhc; DHC1; DHC64C; DHC; DYHC; Dhc 64C; Dhc46C; Dhc64c; Dhc64; Dhc; Dmel\\CG7507; Dmel_CG7507; Dynein; FCP-A; Fs(3)Laborc; Fs(3)Lab; Fs(3)Sz18; HMW MAP; Lab; Su(Gl)77; cDhc64C; cDhc; dhc64C; dhc64c; dhc64; dhc; dynein; l(3)64Ca", "gene_names_refseq": "CD; CG7507; Cdhc; DHC1; DHC64C; DHC; DYHC; Dhc 64C; Dhc46C; Dhc64C; Dhc64c; Dhc64; Dhc; Dmel\\CG7507; Dynein; FCP-A; Fs(3)Laborc; Fs(3)Lab; Fs(3)Sz18; HMW MAP; Lab; Su(Gl)77; cDhc64C; cDhc; dhc64C; dhc64c; dhc64; dhc; dynein; l(3)64Ca", "protein_names_uniprotkb": "Dynein heavy chain, cytoplasmic; DYHC; Dynein heavy chain, cytosolic", "protein_names_refseq": "CG7507-PA; Dhc64C-PA; cytoplasmic dynein heavy chain; cytoplasmic dynenin; dynein HC; dynein heavy chain 64C, isoform A; dynein heavy chain 64c; dynein heavy chain at 64C; dynein heavy-chain; female sterile(3)Laborc; laborc; suppressor of glued 77", "tax_id": 7227, "disease": "lissencephaly (Disease Ontology:DOID:0050453); congenital muscular dystrophy (Disease Ontology:DOID:0050557); complex cortical dysplasia with other brain malformations 13 (Disease Ontology:DOID:0061144); autosomal dominant intellectual developmental disorder 13 (Disease Ontology:DOID:0070043); spinal muscular atrophy with lower extremity predominant 1 (Disease Ontology:DOID:0070351); Charcot-Marie-Tooth disease axonal type 2O (Disease Ontology:DOID:0110175); Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); epilepsy (Disease Ontology:DOID:1826); nervous system disease (Disease Ontology:DOID:863)", "pathway": " (dme:Dmel_CG7507); (R-DME-3371497); (R-DME-6798695); (R-DME-6807878); (R-DME-6811436); (R-DME-9646399)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8089180;8186464", "class_list": "", "function": "Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8IRA5;Q961M8;Q9VZ83", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0003777 microtubule motor activity;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005938 cell cortex;GO:0005875 microtubule associated complex;GO:0000776 kinetochore", "go_biological_process": "GO:0008090 retrograde axonal transport;GO:0000278 mitotic cell cycle;GO:0006886 intracellular protein transport;GO:0008088 axo-dendritic transport;GO:0045198 establishment of epithelial cell apical/basal polarity", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P37276-1", "record_type": "protein", "filter_code": "0000000.0000111.000100.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01842-1", "uniprot_id": [ { "id": "POK_DROME", "url": "https://www.uniprot.org/uniprot/Q01842", "type": "external" } ], "mass": 78574.0, "length": 732, "protein_name": "Ets DNA-binding protein pokkuri", "gene_name": "aop", "organism": "Fruit fly", "refseq_name": "anterior open, isoform C", "refseq_ac": [ { "id": "NP_001259908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259908", "type": "external" } ], "gene_names_uniprotkb": "aop; AOP; Aop; CG3166; DROYANETSB; DROYANET; Dmel\\CG3166; Dmel_CG3166; SK2-1; YAN; Yan; fus6; pok; yan", "gene_names_refseq": "AOP; Aop/Yan; Aop; CG3166; DROYANETSB; DROYANET; Dmel\\CG3166; SK2-1; YAN; Yan; aop/yan; aop; fus6; pok; yan/pok; yan", "protein_names_uniprotkb": "Ets DNA-binding protein pokkuri; Protein anterior open; Protein yan", "protein_names_refseq": "CG3166-PC; SGP cluster fusion defects 6; anterior open, isoform C; anterior open; anterior-open; aop-PC; pokkuri; yan", "tax_id": 7227, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); myeloid neoplasm (Disease Ontology:DOID:0070004); lymphoid leukemia (Disease Ontology:DOID:1037); leukemia (Disease Ontology:DOID:1240); thrombocytopenia (Disease Ontology:DOID:1588); myeloproliferative neoplasm (Disease Ontology:DOID:2226); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (dme:Dmel_CG3166)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;1495974;1505027;16110336;16729063;17569856;17569867;18327897;25589440;26109356;26109357;8033205", "class_list": "", "function": "Ets-related protein that functions as a negative regulator of photoreceptor development acting antagonistically to pnt and the proneural signal mediated by RAS (PubMed:1495974, PubMed:1505027, PubMed:8033205). It acts upstream of SINA to inhibit R7 development (PubMed:1495974, PubMed:1505027)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q6AWH6;Q6NR43;Q9VQ81", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0019904 protein domain specific binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006897 endocytosis;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q01842-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08761-1", "uniprot_id": [ { "id": "MSRA_DROME", "url": "https://www.uniprot.org/uniprot/P08761", "type": "external" } ], "mass": 27698.0, "length": 246, "protein_name": "Peptide methionine sulfoxide reductase", "gene_name": "MsrA", "organism": "Fruit fly", "refseq_name": "methionine sulfoxide reductase A, isoform A", "refseq_ac": [ { "id": "NP_524085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524085", "type": "external" } ], "gene_names_uniprotkb": "MsrA; 29; CG7266; DROZ60MEX; Dmel\\CG7266; Dmel_CG7266; EiP71CD; Eip28; Eip71CD; Eip71C; MSRA; dMsrA; dmsrA; msrA", "gene_names_refseq": "CG7266; DROZ60MEX; Dmel\\CG7266; EiP71CD; Eip28 /29; Eip28/29; Eip28; Eip71CD; Eip71C; MSRA; MsrA; dMsrA; dmsrA; eip28/29; msrA", "protein_names_uniprotkb": "Peptide methionine sulfoxide reductase; 1.8.4.11; Ecdysone-induced protein 28/29 kDa; Methionine-S-sulfoxide reductase; Peptide-methionine (S)-S-oxide reductase", "protein_names_refseq": "CG7266-PA; Ecdysone-induced protein 28/29kD; Eip28/29; Methionine-S-sulfoxide reductase; MsrA-PA; methionine reductase A; methionine sulfoxide reductase A, isoform A; methionine sulfoxide reductase A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7266)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12145281;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;28953965;30529269;3097323", "class_list": "", "function": "Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reduction of methionine sulfoxide in proteins to methionine (PubMed:12145281, PubMed:30529269). Does not catalyze the reverse reaction involving the oxidation of methionine residues (PubMed:30529269)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86NL3;Q8IQM6;Q8IT52;Q9VUP3;Q9VUP4;Q9VUP5", "ec_number_list": [ { "id": "1.8.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.11", "type": "external" } ], "go_molecular_function": "GO:0008113 peptide-methionine (S)-S-oxide reductase activity;GO:0033744 L-methionine:thioredoxin-disulfide S-oxidoreductase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0034599 cellular response to oxidative stress;GO:0008340 determination of adult lifespan;GO:0000096 sulfur amino acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P08761-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29052-1", "uniprot_id": [ { "id": "TF2B_DROME", "url": "https://www.uniprot.org/uniprot/P29052", "type": "external" } ], "mass": 34369.0, "length": 315, "protein_name": "Transcription initiation factor IIB", "gene_name": "TfIIB", "organism": "Fruit fly", "refseq_name": "transcription factor IIB, isoform B", "refseq_ac": [ { "id": "NP_001260349", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260349", "type": "external" } ], "gene_names_uniprotkb": "TfIIB; CG5193; Dmel\\CG5193; Dmel_CG5193; TFIIB; Tfiib; TfllB; dTFIIB; dTfIIB; dmTFIIB; tfIIb", "gene_names_refseq": "CG5193; Dmel\\CG5193; TFIIB; TfIIB; Tfiib; TfllB; dTFIIB; dTfIIB; dmTFIIB; tfIIb", "protein_names_uniprotkb": "Transcription initiation factor IIB; General transcription factor TFIIB", "protein_names_refseq": "CG5193-PB; TfIIB-PB; transcription factor IIB, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5193); (R-DME-674695); (R-DME-6807505); (R-DME-73776); (R-DME-73779); (R-DME-75953); (R-DME-76042)", "pathway_count": 7, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;1557390;16110336;1644295;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6AWH9;Q9VKV7", "ec_number_list": [], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0008270 zinc ion binding;GO:0017025 TBP-class protein binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus", "go_biological_process": "GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0042789 mRNA transcription by RNA polymerase II;GO:0006352 DNA-templated transcription initiation;GO:0051123 RNA polymerase II preinitiation complex assembly;GO:0001174 transcriptional start site selection at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P29052-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O97420-1", "uniprot_id": [ { "id": "U184_DROME", "url": "https://www.uniprot.org/uniprot/O97420", "type": "external" } ], "mass": 10404.0, "length": 96, "protein_name": "UPF0184 protein CG14818", "gene_name": "EG:63B12.12", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001259146", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259146", "type": "external" } ], "gene_names_uniprotkb": "EG:63B12.12; BcDNA:RE09176; BcDNA:RH52516; CG14818; CT34631; Dmel\\CG14818; Dmel_CG14818; Hero9", "gene_names_refseq": "BcDNA:RE09176; BcDNA:RH52516; CG14818; CT34631; Dmel\\CG14818; EG:63B12.12; Hero9", "protein_names_uniprotkb": "UPF0184 protein CG14818", "protein_names_refseq": "CG14818-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14818)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;10731137;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C0PV39", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O97420-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25157-1", "uniprot_id": [ { "id": "GNAL_DROME", "url": "https://www.uniprot.org/uniprot/P25157", "type": "external" } ], "mass": 52753.0, "length": 457, "protein_name": "Guanine nucleotide-binding protein subunit alpha homolog", "gene_name": "cta", "organism": "Fruit fly", "refseq_name": "concertina, isoform A", "refseq_ac": [ { "id": "NP_001036421", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036421", "type": "external" } ], "gene_names_uniprotkb": "cta; 13]]; 13; CG17678; CG40010; CTR; Concertina; Cta; Dmel\\CG17678; Dmel_CG17678; Galpha; conc; mat(2)cta; mat(2)fog", "gene_names_refseq": "CG17678; CG40010; Concertina; Cta; Dmel\\CG17678; GNA12/13; Galpha12/13; Galpha[[12/13]]; Galpha; conc; cta; mat(2)cta; mat(2)fog", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit alpha homolog; Protein concertina", "protein_names_refseq": "CG17678-PA; Galpha[[12/13]] subunit; concertina, isoform A; concertina; cta-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17678); (R-DME-193648); (R-DME-416482); (R-DME-428930); (R-DME-9013148); (R-DME-9013149)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10731132;10748524;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;1899050;25589440;26109356;26109357", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems., [UniProtKB, PubMed]; May play a role in a signal transduction pathway used during gastrulation. Required specifically for the ventral furrow and posterior midgut invaginations, where it is necessary for coordinating cell shape changes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7PL79;Q9U3X3", "ec_number_list": [], "go_molecular_function": "GO:0031752 D5 dopamine receptor binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031526 brush border membrane;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0010470 regulation of gastrulation;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007266 Rho protein signal transduction;GO:0016476 regulation of embryonic cell shape", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P25157-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42271-1", "uniprot_id": [ { "id": "TBG2_DROME", "url": "https://www.uniprot.org/uniprot/P42271", "type": "external" } ], "mass": 51296.0, "length": 457, "protein_name": "Tubulin gamma-2 chain", "gene_name": "gammaTub37C", "organism": "Fruit fly", "refseq_name": "gamma-Tubulin at 37C, isoform B", "refseq_ac": [ { "id": "NP_001260565", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260565", "type": "external" } ], "gene_names_uniprotkb": "gammaTub37C; CG17566; D.m.GAMMA-37C; Dmel\\CG17566; Dmel_CG17566; GTU88*; PL10; Rb1011; TW1; Tub37CD; Tub37C; Tub3B; TubG2; TubG37C; fs(2)TW1; fs(2)TWI; fsTW1; g-Tubulin; gamma Tub37CD; gamma tubulin; gamma-Tub37C; gamma-Tub; gamma-tub37CD; gamma-tub37C; gamma-tubulin37C; gamma-tubulin; gamma-tub; gammaTUB37C; gammaTUB; gammaTub2; gammaTub37CD; gammaTub37c; gammaTub; gamma[mat]; gammatub37C; gammatubulin; gammatub", "gene_names_refseq": "CG17566; D.m.GAMMA-37C; Dmel\\CG17566; GTU88*; PL10; Rb1011; TW1; Tub37C; Tub3B; fs(2)TW1; fs(2)TWI; fsTW1; g-Tubulin; gamma Tub37CD; gamma tubulin; gamma-Tub37C; gamma-Tub; gamma-tub37CD; gamma-tub37C; gamma-tubulin37C; gamma-tubulin; gamma-tub; gammaTUB37C; gammaTUB; gammaTub2; gammaTub37CD; gammaTub37C; gammaTub37c; gammaTub; gamma[mat]; gammatub37C; gammatubulin; gammatub", "protein_names_uniprotkb": "Tubulin gamma-2 chain; Gamma-2-tubulin", "protein_names_refseq": "37CD gamma-tubulin; CG17566-PB; female sterile(2)Ted wright 1; g-tubulin37C; gama-tubulin; gamma Tubulin2; gamma tubulin at 37C; gamma tubulin; gamma-Tubulin 37C; gamma-Tubulin at 37C, isoform B; gamma-Tubulin; gamma-tubulin (37C); gamma-tubulin-2; gamma-tubulin37C; gammaTub37C-PB; gammatubulin; maternal gamma-tubulin", "tax_id": 7227, "disease": "complex cortical dysplasia with other brain malformations 4 (Disease Ontology:DOID:0090138)", "pathway": " (dme:Dmel_CG17566)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;22751930;23785300;25589440;26109356;26109357;9133431;9155007;9698447", "class_list": "", "function": "Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation., [UniProtKB, UniProtKB]; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. Required for oocyte activation and consequently for organization of the female meiotic spindle (PubMed:9155007, PubMed:9698447). Essential for centrosome organization and assembly of biastral mitotic spindles in embryos. Plays a role in stabilizing the augmin complex on the meiotic spindle (PubMed:23785300)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O77160;Q9V476", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0140490 microtubule nucleator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0007020 microtubule nucleation;GO:0007052 mitotic spindle organization;GO:0007057 spindle assembly involved in female meiosis I", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P42271-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46824-1", "uniprot_id": [ { "id": "KLC_DROME", "url": "https://www.uniprot.org/uniprot/P46824", "type": "external" } ], "mass": 58044.0, "length": 508, "protein_name": "Kinesin light chain", "gene_name": "Klc", "organism": "Fruit fly", "refseq_name": "kinesin light chain, isoform B", "refseq_ac": [ { "id": "NP_001261780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261780", "type": "external" } ], "gene_names_uniprotkb": "Klc; CG5433; DKLC; Dmel\\CG5433; Dmel_CG5433; KLC; Kinesin; kinesin; klc", "gene_names_refseq": "CG5433; DKLC; Dmel\\CG5433; KLC; Kinesin; Klc; kinesin; klc", "protein_names_uniprotkb": "Kinesin light chain; KLC", "protein_names_refseq": "CG5433-PB; Klc-PB; kinesin 1 light chain; kinesin I; kinesin light chain subunit of kinesin-1; kinesin light chain, isoform B; kinesin-1 light chain", "tax_id": 7227, "disease": "nonsyndromic deafness (Disease Ontology:DOID:0050563); SPOAN syndrome (Disease Ontology:DOID:0060491); Alzheimer's disease 1 (Disease Ontology:DOID:0080348); Alzheimer's disease (Disease Ontology:DOID:10652); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378)", "pathway": " (dme:Dmel_CG5433); (R-DME-983189)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;8514798", "class_list": "", "function": "Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity., [UniProtKB]; Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9VU05", "ec_number_list": [], "go_molecular_function": "GO:0019894 kinesin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005871 kinesin complex", "go_biological_process": "GO:0007018 microtubule-based movement;GO:0046843 dorsal appendage formation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P46824-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23487-1", "uniprot_id": [ { "id": "MEX1_DROME", "url": "https://www.uniprot.org/uniprot/P23487", "type": "external" } ], "mass": 9424.0, "length": 83, "protein_name": "Protein midgut expression 1", "gene_name": "mex1", "organism": "Fruit fly", "refseq_name": "midgut expression 1, isoform C", "refseq_ac": [ { "id": "NP_001261880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261880", "type": "external" } ], "gene_names_uniprotkb": "mex1; CG7936; Dmel\\CG7936; Dmel_CG7936", "gene_names_refseq": "CG7936; Dmel\\CG7936; mex1", "protein_names_uniprotkb": "Protein midgut expression 1", "protein_names_refseq": "CG7936-PC; MEX; mex1-PC; midgut expression 1, isoform C; midgut expression 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7936)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;1985021;25589440;26109356;26109357", "class_list": "", "function": "Involved in morphogenesis and development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VUP7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P23487-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22468-1", "uniprot_id": [ { "id": "GDL_DROME", "url": "https://www.uniprot.org/uniprot/P22468", "type": "external" } ], "mass": 22653.0, "length": 194, "protein_name": "Gonadal protein gdl", "gene_name": "gdl", "organism": "Fruit fly", "refseq_name": "gonadal, isoform A", "refseq_ac": [ { "id": "NP_001027127", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027127", "type": "external" } ], "gene_names_uniprotkb": "gdl; CG33088; CG33756; CG7268; Dmel\\CG33756; Dmel_CG33756", "gene_names_refseq": "CG33088; CG33756; CG7268; Dmel\\CG33756; gdl", "protein_names_uniprotkb": "Gonadal protein gdl", "protein_names_refseq": "CG33756-PA; gdl-PA; gonadal, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33756)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;2117521;2497054;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V3J8;Q9U5V5;Q9VUP2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P22468-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24106-1", "uniprot_id": [ { "id": "HID_DROME", "url": "https://www.uniprot.org/uniprot/Q24106", "type": "external" } ], "mass": 43877.0, "length": 410, "protein_name": "Cell death protein hid", "gene_name": "hid", "organism": "Fruit fly", "refseq_name": "head involution defective, isoform B", "refseq_ac": [ { "id": "NP_001262010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262010", "type": "external" } ], "gene_names_uniprotkb": "hid; CG5123; Dmel\\CG5123; Dmel_CG5123; HID; Hid1; Hid; W; hid1; his; l(3)05014", "gene_names_refseq": "CG5123; Dmel\\CG5123; HID; Hid1; Hid; W; hid1; hid; his; l(3)05014", "protein_names_uniprotkb": "Cell death protein hid; Protein head involution defective; Protein wrinkled", "protein_names_refseq": "CG5123-PB; head involuted defective; head involution defective 1; head involution defective, isoform B; head involution defect; head-involution defective; head-involution-defective; hid-PB; wrinkled; wrinkler", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5123)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10731132;11511363;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18166655;18327897;22615583;22964637;25589440;26109356;26109357;7622034;9740659", "class_list": "", "function": "Activator of apoptosis, with grim and rpr, that acts on the effector Dredd (PubMed:22615583, PubMed:9740659). Seems to act genetically upstream of baculoviral anti-apoptotic p35 (PubMed:7622034). Blocks Diap2 from binding and inactivating the effector caspase Drice (PubMed:18166655). Might regulate apoptosis downstream of Clbn/NEMF (PubMed:22964637)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9VVP1", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process;GO:0140311 protein sequestering activity;GO:1990525 BIR domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0097190 apoptotic signaling pathway;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage;GO:0016239 positive regulation of macroautophagy", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q24106-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "M9PI93-1", "uniprot_id": [ { "id": "M9PI93_DROME", "url": "https://www.uniprot.org/uniprot/M9PI93", "type": "external" } ], "mass": 62810.0, "length": 575, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG13700", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform E", "refseq_ac": [ { "id": "NP_001262013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262013", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG13700; CG13700; Dmel_CG13700", "gene_names_refseq": "CG13700; Dmel\\CG13700", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG13700-PE; uncharacterized protein, isoform E", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13700)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "M9PI93-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20153-1", "uniprot_id": [ { "id": "USP_DROME", "url": "https://www.uniprot.org/uniprot/P20153", "type": "external" } ], "mass": 55244.0, "length": 508, "protein_name": "Protein ultraspiracle", "gene_name": "usp", "organism": "Fruit fly", "refseq_name": "ultraspiracle, isoform B", "refseq_ac": [ { "id": "NP_001259168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259168", "type": "external" } ], "gene_names_uniprotkb": "usp; 2C; CF1; CG4380; Cf1; DmUSP; DmUsp; Dmel\\CG4380; Dmel_CG4380; EG:22E5.1; NR2B4; USP; Usp; XR2C; cf1; dUSP; dmUSP; l(1)2Cf; l(1)usp", "gene_names_refseq": "2C; CF1/USP; CF1/Usp; CF1; CG4380; Cf1; DmUSP; DmUsp; Dmel\\CG4380; EG:22E5.1; NR2B4; USP; Usp; XR2C; cf1; dUSP; dmUSP; l(1)2Cf; l(1)usp; usp", "protein_names_uniprotkb": "Protein ultraspiracle; Chorion factor 1; Nuclear receptor subfamily 2 group B member 4; XR2C", "protein_names_refseq": "CG4380-PB; X receptor at 2C; chorion factor 1; chorion factor CF1; ultraspiracle, isoform B; ultraspiracle; ultraspiricle; usp-PB", "tax_id": 7227, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); alcoholic cardiomyopathy (Disease Ontology:DOID:12935); congenital heart disease (Disease Ontology:DOID:1682); pancreatic cancer (Disease Ontology:DOID:1793); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); lung non-small cell carcinoma (Disease Ontology:DOID:3908); papillary thyroid carcinoma (Disease Ontology:DOID:3969); prostate carcinoma in situ (Disease Ontology:DOID:8634); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (dme:Dmel_CG4380); (R-DME-159418); (R-DME-200425); (R-DME-381340); (R-DME-383280); (R-DME-400206); (R-DME-5362517); (R-DME-9029569); (R-DME-9616222); (R-DME-9623433); (R-DME-9707564); (R-DME-9841922)", "pathway_count": 12, "publication_count": 20, "publication_id_list": "10731132;10731137;12537568;12537569;12537572;12537573;12537574;15996653;16110336;17569856;17569867;18327897;2120114;2165589;2169594;23136906;25589440;26109356;26109357;8247157", "class_list": "", "function": "Receptor for ecdysone. May be an important modulator of insect metamorphosis. Plays an important part in embryonic and post-embryonic development. Binds to ecdysone response elements (ECRES) such as in the promoter region of s15 chorion gene., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W535", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005102 signaling receptor binding;GO:0008270 zinc ion binding;GO:0046982 protein heterodimerization activity;GO:0003707 nuclear steroid receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0030425 dendrite;GO:0008230 ecdysone receptor holocomplex;GO:0005700 polytene chromosome;GO:0008232 activator ecdysone receptor complex", "go_biological_process": "GO:0040034 regulation of development, heterochronic;GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0016322 neuron remodeling;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P20153-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46461-1", "uniprot_id": [ { "id": "NSF1_DROME", "url": "https://www.uniprot.org/uniprot/P46461", "type": "external" } ], "mass": 82555.0, "length": 745, "protein_name": "Vesicle-fusing ATPase 1", "gene_name": "comt", "organism": "Fruit fly", "refseq_name": "comatose, isoform B", "refseq_ac": [ { "id": "NP_001259506", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259506", "type": "external" } ], "gene_names_uniprotkb": "comt; CG 1618; CG1618; Comt; DmNSF; Dmel\\CG1618; Dmel_CG1618; NSF 1; NSF-1; NSF1; NSF; Nsf1; Nsf; com; dNSF-1; dNSF1; dNSF; dNsf1; dnsf1", "gene_names_refseq": "CG 1618; CG1618; Comt; DmNSF; Dmel\\CG1618; NSF 1; NSF-1; NSF1; NSF; Nsf1; Nsf; comt; com; dNSF-1; dNSF1; dNSF; dNsf1; dnsf1", "protein_names_uniprotkb": "Vesicle-fusing ATPase 1; 3.6.4.6; N-ethylmaleimide-sensitive fusion protein 1; NEM-sensitive fusion protein 1; NSF-1; Protein comatose; Vesicular-fusion protein NSF1; dNsf-1", "protein_names_refseq": "CG1618-PB; N-Ethylmaleimide-sensitive factor; N-ethyl-maleimide sensitive fusion protein; N-ethylmaleimide-sensitive factor 1; N-ethylmaleimide-sensitive fusion protein; NEM-sensitive fusion protein; comatose, isoform B; comatose; comt-PB", "tax_id": 7227, "disease": "oculocutaneous albinism (Disease Ontology:DOID:0050632); autism spectrum disorder (Disease Ontology:DOID:0060041); developmental and epileptic encephalopathy 96 (Disease Ontology:DOID:0070377); Parkinson's disease (Disease Ontology:DOID:14330); epilepsy (Disease Ontology:DOID:1826); temporal lobe epilepsy (Disease Ontology:DOID:3328); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (dme:Dmel_CG1618)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8202553", "class_list": "", "function": "Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VYF4", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031594 neuromuscular junction;GO:0043195 terminal bouton;GO:0005795 Golgi stack;GO:0099523 presynaptic cytosol", "go_biological_process": "GO:0035494 SNARE complex disassembly;GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0099504 synaptic vesicle cycle;GO:0007274 neuromuscular synaptic transmission;GO:0070050 neuron cellular homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P46461-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37236-1", "uniprot_id": [ { "id": "FRQ1_DROME", "url": "https://www.uniprot.org/uniprot/P37236", "type": "external" } ], "mass": 21668.0, "length": 187, "protein_name": "Frequenin-1", "gene_name": "Frq1", "organism": "Fruit fly", "refseq_name": "frequenin 1, isoform C", "refseq_ac": [ { "id": "NP_001033853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033853", "type": "external" } ], "gene_names_uniprotkb": "Frq1; CG5744; Dmel\\CG5744; Dmel_CG5744; Frq; HL-II; frq1; frq", "gene_names_refseq": "CG5744; Dmel\\CG5744; Frq1; Frq; HL-II; frq1; frq", "protein_names_uniprotkb": "Frequenin-1; d-FRQ", "protein_names_refseq": "CG5744-PC; Frequenin2; Frq1-PC; frequenin 1, isoform C; frequenin 1; frequenin; frequentin; frequinin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5744)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;17970740;25074811;25589440;26109356;26109357;8101711", "class_list": "", "function": "Ca(2+)-dependent modulation of synaptic efficacy (PubMed:17970740, PubMed:8101711). Also plays a role in axon terminal morphology (PubMed:17970740)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V4Q8", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008048 calcium sensitive guanylate cyclase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0098793 presynapse;GO:0045202 synapse", "go_biological_process": "GO:0007528 neuromuscular junction development;GO:0007268 chemical synaptic transmission;GO:0046928 regulation of neurotransmitter secretion;GO:0009966 regulation of signal transduction;GO:0007269 neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P37236-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P91891-1", "uniprot_id": [ { "id": "MO25_DROME", "url": "https://www.uniprot.org/uniprot/P91891", "type": "external" } ], "mass": 39385.0, "length": 339, "protein_name": "Protein Mo25", "gene_name": "Mo25", "organism": "Fruit fly", "refseq_name": "Mo25, isoform B", "refseq_ac": [ { "id": "NP_001261958", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261958", "type": "external" } ], "gene_names_uniprotkb": "Mo25; CG4083; DmMo25; Dmel\\CG4083; Dmel_CG4083; Dmo25; dMo25; l(3)00274; mo25", "gene_names_refseq": "CG4083; DmMo25; Dmel\\CG4083; Dmo25; Mo25; dMo25; l(3)00274; mo25", "protein_names_uniprotkb": "Protein Mo25; dMo25", "protein_names_refseq": "CG4083-PB; Mo25, isoform B; Mo25-PB", "tax_id": 7227, "disease": "cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); transient cerebral ischemia (Disease Ontology:DOID:224); hepatocellular carcinoma (Disease Ontology:DOID:684); hyperthyroidism (Disease Ontology:DOID:7998)", "pathway": " (dme:Dmel_CG4083); (R-DME-6798695)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8672247", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q540S2;Q9VV85", "ec_number_list": [], "go_molecular_function": "GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P91891-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23488-1", "uniprot_id": [ { "id": "OPAP_DROME", "url": "https://www.uniprot.org/uniprot/P23488", "type": "external" } ], "mass": 7938.0, "length": 83, "protein_name": "Male-specific opa-containing protein", "gene_name": "msopa", "organism": "Fruit fly", "refseq_name": "male-specific opa containing gene, isoform B", "refseq_ac": [ { "id": "NP_001262203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262203", "type": "external" } ], "gene_names_uniprotkb": "msopa; CG14560; Dmel\\CG14560; Dmel_CG14560", "gene_names_refseq": "CG14560; Dmel\\CG14560; msopa", "protein_names_uniprotkb": "Male-specific opa-containing protein; Protein dromsopa", "protein_names_refseq": "CG14560-PB; dromsopa; drosophila male specific opa containing gene; male-specific opa containing gene, isoform B; msopa-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14560)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;1674131;17569856;17569867;1883837;25589440;26109356;26109357", "class_list": "", "function": "May be a male specific regulatory factor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VNV8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007320 insemination;GO:0006952 defense response;GO:0007618 mating", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P23488-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09956-1", "uniprot_id": [ { "id": "ZEST_DROME", "url": "https://www.uniprot.org/uniprot/P09956", "type": "external" } ], "mass": 61961.0, "length": 575, "protein_name": "Regulatory protein zeste", "gene_name": "z", "organism": "Fruit fly", "refseq_name": "zeste, isoform B", "refseq_ac": [ { "id": "NP_001033827", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033827", "type": "external" } ], "gene_names_uniprotkb": "z; CG7803; Dmel\\CG7803; Dmel_CG7803; EG:BACH59J11.3; Zeste; Z; e(bx); en-bx", "gene_names_refseq": "CG7803; Dmel\\CG7803; EG:BACH59J11.3; Zeste; Z; e(bx); en-bx; z", "protein_names_uniprotkb": "Regulatory protein zeste", "protein_names_refseq": "CG7803-PB; enhancer-of-bithorax; z-PB; zeste, isoform B; zeste", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7803)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10731132;10731137;12537568;12537572;12537573;12537574;16110336;17569856;17569867;2118108;25589440;26109356;26109357;3125410;3582372;8355601;8491197", "class_list": "", "function": "Involved in transvection phenomena (= synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24596;Q7YU84;Q9V3F1", "ec_number_list": [], "go_molecular_function": "GO:0043565 sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005705 polytene chromosome interband", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0010628 positive regulation of gene expression;GO:0045893 positive regulation of DNA-templated transcription;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P09956-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O01346-1", "uniprot_id": [ { "id": "EGH_DROME", "url": "https://www.uniprot.org/uniprot/O01346", "type": "external" } ], "mass": 51984.0, "length": 457, "protein_name": "Glycolipid beta-1,4-mannosyltransferase egh", "gene_name": "egh", "organism": "Fruit fly", "refseq_name": "egghead, isoform D", "refseq_ac": [ { "id": "NP_001284829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284829", "type": "external" } ], "gene_names_uniprotkb": "egh; CG9659; l(1)3Ae; zw4", "gene_names_refseq": "4ManT; CG9659; Dmel\\CG9659; EG:BACR25B3.8; Egh; ZW-4; beta1; egh; l(1)3Ae; l(1)zw4; zw-4; zw4", "protein_names_uniprotkb": "Glycolipid beta-1,4-mannosyltransferase egh; 2.4.1.-; GDP-Man:beta-Glc beta1,4-Mannosyl transferase; Protein egghead; Protein zeste-white 4", "protein_names_refseq": "CG9659-PD; beta1,4-mannosyltransferase; egghead, isoform D; egghead; egh-PD; zeste-white 4", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9659)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;10731137;12454022;12537572;15611100;16182276;17498683;9012507", "class_list": "glycogene;glycosyltransferase", "function": "A beta-1,4-glycosyltransferase that catalyzes the transfer of a mannose residue from GDP-mannose in a beta-1,4 linkage to glycosphingolipids (PubMed:12454022). Involved in the biosynthesis of arthroseries glycosphingolipids upstream of brn/brainiac; required for sequential elongation steps (PubMed:12454022, PubMed:15611100). Catalyzes addition of the second monosaccharide residue to form the dihexosylceramide glycolipid Man(beta1-4)Glc(beta1-1)Cer (MacCer) (PubMed:12454022). Highly specific for substrates containing a terminal beta-linked glucose residue (PubMed:12454022). Neurogenic protein implicated in epithelial development (PubMed:9012507). Required in the female germline for establishing and maintaining the follicular epithelium throughout oogenesis (PubMed:9012507). Collaborates with Notch on the apical surface of follicle cells to mediate germline-follicle cell adhesion (PubMed:9012507). Required, along with brn, in the lobula complex primordium for establishment of the lamina/lobula cortex boundary and correct targeting of photoreceptor (R-cell) neuron axons (PubMed:16182276). Downstream glycosphingolipid biosynthesis by beta4GalNAcTA is involved in motor coordination and locomotion (PubMed:17498683). Downstream glycosphingolipid biosynthesis by beta4GalNAcTB is involved in oocyte dorsal follicular cell fate specification by EGFR signaling (PubMed:17498683)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V3W0;C0PTV2;O01347;Q9V3B0", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0019187 beta-1,4-mannosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0008049 male courtship behavior;GO:0007281 germ cell development;GO:0007411 axon guidance;GO:0045165 cell fate commitment;GO:0048935 peripheral nervous system neuron development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O01346-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O01668-1", "uniprot_id": [ { "id": "OPS6_DROME", "url": "https://www.uniprot.org/uniprot/O01668", "type": "external" } ], "mass": 41691.0, "length": 369, "protein_name": "Opsin Rh6", "gene_name": "Rh6", "organism": "Fruit fly", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Rh6; CG5192", "gene_names_refseq": "", "protein_names_uniprotkb": "Opsin Rh6; Rhodopsin Rh6, long-wavelength", "protein_names_refseq": "", "tax_id": 7227, "disease": "sensorineural hearing loss (Disease Ontology:DOID:10003)", "pathway": " (dme:Dmel_CG5192); (R-DME-419771)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;9109375", "class_list": "", "function": "Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8SXF4;Q9VF58", "ec_number_list": [], "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016028 rhabdomere", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007605 sensory perception of sound;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O01668-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O01939-1", "uniprot_id": [ { "id": "MST_DROME", "url": "https://www.uniprot.org/uniprot/O01939", "type": "external" } ], "mass": 64783.0, "length": 574, "protein_name": "Protein misato", "gene_name": "mst", "organism": "Fruit fly", "refseq_name": "misato, isoform B", "refseq_ac": [ { "id": "NP_001285518", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285518", "type": "external" } ], "gene_names_uniprotkb": "mst; 2; CG1424; Dmel\\CG1424; Dmel_CG1424; LB-20; LB20; l(1)19Fg; l(1)LB14; l(1)LB20; lLB14", "gene_names_refseq": "CG1424; Dmel\\CG1424; LB-20; LB20; MST1/2; l(1)19Fg; l(1)LB14; l(1)LB20; lLB14; mst", "protein_names_uniprotkb": "Protein misato", "protein_names_refseq": "CG1424-PB; MST1/2; lethal(1)19Fg; misato, isoform B; mst-PB", "tax_id": 7227, "disease": "myotonia congenita (Disease Ontology:DOID:2106)", "pathway": " (dme:Dmel_CG1424)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;9144213", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MSB2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0010636 positive regulation of mitochondrial fusion;GO:0090307 mitotic spindle assembly;GO:0007005 mitochondrion organization;GO:0000070 mitotic sister chromatid segregation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O01939-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O02193-1", "uniprot_id": [ { "id": "MOF_DROME", "url": "https://www.uniprot.org/uniprot/O02193", "type": "external" } ], "mass": 92657.0, "length": 827, "protein_name": "Histone acetyltransferase MOF", "gene_name": "mof", "organism": "Fruit fly", "refseq_name": "males absent on the first", "refseq_ac": [ { "id": "NP_511051", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_511051", "type": "external" } ], "gene_names_uniprotkb": "mof; CG3025", "gene_names_refseq": "CG3025; Dmel\\CG3025; MOF; Mof; dMOF; dmMOF; max; mof", "protein_names_uniprotkb": "Histone acetyltransferase MOF; 2.3.1.48; Males-absent on the first protein", "protein_names_refseq": "CG3025-PA; MOF histone acetylase; males absent on first; males absent on the first; males-absent on the X; males-absent-on-the-first; mof-PA", "tax_id": 7227, "disease": "breast cancer (Disease Ontology:DOID:1612); clear cell renal cell carcinoma (Disease Ontology:DOID:4467)", "pathway": " (dme:Dmel_CG3025); (R-DME-3214847); (R-DME-9772755)", "pathway_count": 3, "publication_count": 21, "publication_id_list": "10679323;10731132;10882077;11014199;11258702;12537569;12537572;15964847;16543150;17878295;18039888;18510926;20620953;20620954;22421046;22723752;23084834;28510597;32502394;34133927;9155031", "class_list": "", "function": "Histone acetyltransferase that catalyzes the formation of the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction and constitutes the only acetylation mark intergenerationally transmitted (PubMed:10882077, PubMed:18510926, PubMed:20620953, PubMed:22421046, PubMed:32502394). Catalytic component of the male-specific lethal (MSL) complex, a multiprotein complex essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation) (PubMed:10882077, PubMed:11014199, PubMed:16543150, PubMed:18510926, PubMed:34133927, PubMed:9155031). The MSL complex specifically associates with the single X chromosome in males and mediates formation of H4K16ac, promoting a two-fold activation of X chromosome (PubMed:11258702, PubMed:18510926, PubMed:20620953, PubMed:22421046). Dosage compensation ensures that males with a single X chromosome have the same amount of most X-linked gene products as females with two X chromosomes (PubMed:18510926, PubMed:9155031). In oocytes, mof is also part of a maternal MSL subcomplex that mediates H4K16ac deposition for intergenerational transmission: H4K16ac prepares the chromatin landscape for establishment of nucleosome accessibility and poises genes for future activation (PubMed:32502394). H4K16ac constitutes the only acetylation mark maintained from oocytes to fertilized embryos (PubMed:32502394). Mof also constitutes the catalytic component of the non-specific lethal (NLS) complex, which promotes expression of housekeeping genes on X chromosome and autosomes (PubMed:20620953, PubMed:20620954, PubMed:22723752). The NSL complex promotes strong expression of housekeeping genes compared to the two-fold expression mediated by the MSL complex on X chromosome, suggesting that the activation potential of mof is constrained in the context of dosage compensation (PubMed:20620953)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A8B845;A8B850;A8B854;A8B859;A8B879;A8B889;A8B895;A8B8A1;A8ILB7;A8ILC1;A8ILC8;A8ILD1;A8ILD6;A8ILE1;A8ILE5;Q9W463", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0004402 histone acetyltransferase activity;GO:0046972 histone H4K16 acetyltransferase activity;GO:0106222 lncRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0035267 NuA4 histone acetyltransferase complex;GO:0005667 transcription regulator complex;GO:0000228 nuclear chromosome;GO:0072487 MSL complex", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0030330 DNA damage response, signal transduction by p53 class mediator;GO:0009047 dosage compensation by hyperactivation of X chromosome;GO:0140861 DNA repair-dependent chromatin remodeling;GO:0141137 positive regulation of gene expression, epigenetic", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "O02193-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O02373-1", "uniprot_id": [ { "id": "UGDH_DROME", "url": "https://www.uniprot.org/uniprot/O02373", "type": "external" } ], "mass": 52875.0, "length": 476, "protein_name": "UDP-glucose 6-dehydrogenase", "gene_name": "sgl", "organism": "Fruit fly", "refseq_name": "sugarless", "refseq_ac": [ { "id": "NP_476980", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476980", "type": "external" } ], "gene_names_uniprotkb": "sgl; CG10072; kiwi; ska", "gene_names_refseq": "8310; BG01214; CG10072; Dmel\\CG10072; Sgl; UDP-GlcDH; UDPGDH; XIII; kiwi; l(3)05007; l(3)08310; l(3)10503; l(3)65CEd; l(3)SG9; sgl; ska; sl", "protein_names_uniprotkb": "UDP-glucose 6-dehydrogenase; 1.1.1.22; Protein sugarless; Protein suppenkasper; UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH", "protein_names_refseq": "CG10072-PA; UDP-glucose 6-dehydrogenase; UDP-glucose dehydrogenase; distal W5.4 group XIII; kiwi; lethal(3)SG9; sgl-PA; sugarless; suppenkasper", "tax_id": 7227, "disease": "developmental and epileptic encephalopathy 84 (Disease Ontology:DOID:0112219)", "pathway": " (dme:Dmel_CG10072); (R-DME-173599)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;9217004;9272947;9342049", "class_list": "", "function": "Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate and heparan sulfate. Required for wingless signaling in different tissues., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O02647;Q9VRZ9", "ec_number_list": [ { "id": "1.1.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.22", "type": "external" } ], "go_molecular_function": "GO:0051287 NAD binding;GO:0003979 UDP-glucose 6-dehydrogenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0006024 glycosaminoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0006065 UDP-glucuronate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O02373-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O17444-1", "uniprot_id": [ { "id": "VACHT_DROME", "url": "https://www.uniprot.org/uniprot/O17444", "type": "external" } ], "mass": 64314.0, "length": 578, "protein_name": "Vesicular acetylcholine transporter", "gene_name": "VAChT", "organism": "Fruit fly", "refseq_name": "vesicular acetylcholine transporter", "refseq_ac": [ { "id": "NP_477138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477138", "type": "external" } ], "gene_names_uniprotkb": "VAChT; CG32848", "gene_names_refseq": "CG12345; CG32848; CT41182; Chn; Dmel\\CG32848; VACHT; VAChT; VACht; VAcht; VaChT; Vacht; chn; dVAChT; vAChT; vacht", "protein_names_uniprotkb": "Vesicular acetylcholine transporter; VAChT", "protein_names_refseq": "CG32848-PA; Cha's neighbour; VAChT-PA; vesicular acetylcholine transporter", "tax_id": 7227, "disease": "congenital myasthenic syndrome 21 (Disease Ontology:DOID:0110672); Alzheimer's disease (Disease Ontology:DOID:10652); Huntington's disease (Disease Ontology:DOID:12858); asthma (Disease Ontology:DOID:2841); bladder disease (Disease Ontology:DOID:365)", "pathway": " (dme:Dmel_CG32848); (R-DME-264642); (R-DME-8856825); (R-DME-8856828)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10731132;12537572;29034290;9446576", "class_list": "", "function": "Involved in acetylcholine transport into synaptic vesicles., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9VE42", "ec_number_list": [], "go_molecular_function": "GO:0005277 acetylcholine transmembrane transporter activity", "go_cellular_component": "GO:0043195 terminal bouton;GO:0030122 AP-2 adaptor complex;GO:0030121 AP-1 adaptor complex", "go_biological_process": "GO:0007268 chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O17444-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O18412-1", "uniprot_id": [ { "id": "FZO_DROME", "url": "https://www.uniprot.org/uniprot/O18412", "type": "external" } ], "mass": 81565.0, "length": 718, "protein_name": "Transmembrane GTPase fzo", "gene_name": "fzo", "organism": "Fruit fly", "refseq_name": "fuzzy onions", "refseq_ac": [ { "id": "NP_732840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_732840", "type": "external" } ], "gene_names_uniprotkb": "fzo; CG4568", "gene_names_refseq": "CG4568; Dmel\\CG4568; Fzo; MFN1; anon-WO0125274.1; anon-WO0125274.25; anon-WO0125274.26; fzo; mfn1", "protein_names_uniprotkb": "Transmembrane GTPase fzo; 3.6.5.-; Protein fuzzy onions", "protein_names_refseq": "CG4568-PA; fuzzy onions; fzo-PA", "tax_id": 7227, "disease": "Charcot-Marie-Tooth disease type 2 (Disease Ontology:DOID:0050539); Charcot-Marie-Tooth disease type 6 (Disease Ontology:DOID:0080068); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Charcot-Marie-Tooth disease type 2A2A (Disease Ontology:DOID:0110155); Charcot-Marie-Tooth disease type 2A2B (Disease Ontology:DOID:0111557); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); prediabetes syndrome (Disease Ontology:DOID:11716); carotid stenosis (Disease Ontology:DOID:13001); multiple symmetric lipomatosis (Disease Ontology:DOID:14116); primary pulmonary hypertension (Disease Ontology:DOID:14557); depressive disorder (Disease Ontology:DOID:1596); transient cerebral ischemia (Disease Ontology:DOID:224); pulmonary fibrosis (Disease Ontology:DOID:3770); myocardial infarction (Disease Ontology:DOID:5844); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG4568); (R-DME-5205685); (R-DME-9013419); (R-DME-983231)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10731132;12128227;12537572;18799731;9230308", "class_list": "", "function": "Essential transmembrane GTPase, which mediates mitochondrial fusion during spermatogenesis (PubMed:18799731, PubMed:9230308). In early spermatocytes, fusion of mitochondria give rise to two organelles named Nebenkern and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission (PubMed:18799731, PubMed:9230308). Essential for fertility (PubMed:9230308)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V3Y6;Q9VCP7", "ec_number_list": [ { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005740 mitochondrial envelope;GO:0005741 mitochondrial outer membrane;GO:0016020 membrane", "go_biological_process": "GO:0030382 sperm mitochondrion organization;GO:0010636 positive regulation of mitochondrial fusion;GO:0007283 spermatogenesis;GO:0008053 mitochondrial fusion;GO:0051646 mitochondrion localization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O18412-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O44386-1", "uniprot_id": [ { "id": "ITA3_DROME", "url": "https://www.uniprot.org/uniprot/O44386", "type": "external" } ], "mass": 124545.0, "length": 1115, "protein_name": "Integrin alpha-PS3", "gene_name": "scb", "organism": "Fruit fly", "refseq_name": "scab, isoform B", "refseq_ac": [ { "id": "NP_523750", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523750", "type": "external" } ], "gene_names_uniprotkb": "scb; CG8095; Vol; alphaPS3", "gene_names_refseq": "&agr-PS3; CG8095; CT21280; CT36929; Dm0620; Dmel\\CG8095; E(Sev-CycE)E93; E(sev-cycE)[e93]; ITA3; Integrin alpha PS3; ItgaPS3; PS3; Vol; aPS3; alpha-PS3; alphaInt3; alphaPS3; alpha[[PS3]]; beta[[PS3]; integrin; l(2)01288; l(2)51Ea; scb; vol", "protein_names_uniprotkb": "Integrin alpha-PS3; Position-specific antigen subunit alpha-3; Protein scab; Protein volado", "protein_names_refseq": "CG8095-PB; aVolado; alpha Position-Specific antigen 3; alpha3 integrin subunit; alphaPS3 integrin; beta[[PS3]]integrin; complementation group 2.11; integrin alpha PS3; integrin alphaPS3 subunit; laminin receptor integrin alpha-PS3; lethal (2) 51Ea; scab, isoform B; scab; scb-PB; volado", "tax_id": 7227, "disease": "stroke (Disease Ontology:DOID:0051061); von Willebrand's disease 1 (Disease Ontology:DOID:0060573); von Willebrand's disease 2 (Disease Ontology:DOID:0060574); thrombosis (Disease Ontology:DOID:0060903); sensorineural hearing loss (Disease Ontology:DOID:10003); hypertension (Disease Ontology:DOID:10763); iron deficiency anemia (Disease Ontology:DOID:11758); Behcet's disease (Disease Ontology:DOID:13241); thrombocytopenia (Disease Ontology:DOID:1588); breast cancer (Disease Ontology:DOID:1612); retinal vein occlusion (Disease Ontology:DOID:1727); pancreatic cancer (Disease Ontology:DOID:1793); Glanzmann's thrombasthenia (Disease Ontology:DOID:2219); arteriosclerosis (Disease Ontology:DOID:2349); cerebral infarction (Disease Ontology:DOID:3526); lung non-small cell carcinoma (Disease Ontology:DOID:3908); myocardial infarction (Disease Ontology:DOID:5844); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dme:Dmel_CG8095); (R-DME-198933); (R-DME-202733); (R-DME-210991); (R-DME-216083); (R-DME-3000170); (R-DME-445144); (R-DME-445355); (R-DME-6798695)", "pathway_count": 9, "publication_count": 11, "publication_id_list": "10731132;12537572;15469969;17893096;18925939;19035354;19349973;23426364;40245499;9409675;9461212", "class_list": "", "function": "Integrin alpha-PS3/beta-PS is a receptor for laminin. Also binds to wb. Important during embryogenesis for the development of the trachea, dorsal vessel and salivary gland, as well as for dorsal closure. Required for short-term memory processes. Minor involvement in the establishment of the oocyte anterior-posterior length. Plays a role in timely border cell migration during oogenesis, probably mediated by JNK signaling. Integrin alpha-PS3/Itgbn is required for effective phagocytosis of apoptotic cells during embryonic development and for the phagocytic elimination of S.aureus by mediating the binding of S.aureus peptidoglycan to larval hemocytes, which probably activates a signaling pathway involving Rac1 and Rac2. Integrin alpha-PS3/Itgbn also regulates Fak activity during neuromuscular junction (NMJ) growth and is required for its activation in presynapsis of NMJs. Seems to be dispensable for major morphogenetic processes., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 21, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "O44387;O46186;Q58CK3;Q6AWK3;Q9V7A3", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0016020 membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0007613 memory;GO:0016477 cell migration;GO:0006909 phagocytosis;GO:0007614 short-term memory", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "O44386-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.1100000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O46037-1", "uniprot_id": [ { "id": "VINC_DROME", "url": "https://www.uniprot.org/uniprot/O46037", "type": "external" } ], "mass": 106302.0, "length": 961, "protein_name": "Vinculin", "gene_name": "Vinc", "organism": "Fruit fly", "refseq_name": "vinculin, isoform B", "refseq_ac": [ { "id": "NP_001284813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284813", "type": "external" } ], "gene_names_uniprotkb": "Vinc; CG3299; CT11081; Dmel\\CG3299; Dmel_CG3299; Dmvincp; EG:103B4.1; VINC; Vin2EF; Vin; vinc", "gene_names_refseq": "CG3299; CT11081; Dmel\\CG3299; Dmvincp; EG:103B4.1; VINC; Vin2EF; Vinc; Vin; vinc", "protein_names_uniprotkb": "Vinculin", "protein_names_refseq": "CG3299-PB; Vinc-PB; vinculin at 2EF; vinculin, isoform B", "tax_id": 7227, "disease": "hypertrophic cardiomyopathy 15 (Disease Ontology:DOID:0110321); dilated cardiomyopathy 1W (Disease Ontology:DOID:0110446); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930)", "pathway": " (dme:Dmel_CG3299); (R-DME-114608); (R-DME-445355); (R-DME-6798695); (R-DME-9764561); (R-DME-9958825)", "pathway_count": 6, "publication_count": 15, "publication_id_list": "10731132;10731137;12537568;12537569;12537572;12537573;12537574;16110336;17372656;17569856;17569867;25589440;26109356;26109357;9280281", "class_list": "", "function": "Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0005198 structural molecule activity;GO:0008013 beta-catenin binding;GO:0045294 alpha-catenin binding", "go_cellular_component": "GO:0098592 cytoplasmic side of apical plasma membrane;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "O46037-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O46101-1", "uniprot_id": [ { "id": "TSN2A_DROME", "url": "https://www.uniprot.org/uniprot/O46101", "type": "external" } ], "mass": 26894.0, "length": 244, "protein_name": "Tetraspanin-2A", "gene_name": "Tsp2A", "organism": "Fruit fly", "refseq_name": "tetraspanin 2A, isoform B", "refseq_ac": [ { "id": "NP_001188523", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188523", "type": "external" } ], "gene_names_uniprotkb": "Tsp2A; CG11415", "gene_names_refseq": "CG11415; D8.7; Dm.Tsp2A; Dmel\\CG11415; EG:8D8.7; Tsp2A; Tsp2a; tsp2A; tsp2a", "protein_names_uniprotkb": "Tetraspanin-2A", "protein_names_refseq": "CG11415-PB; Tsp2A-PB; tetraspanin 2A, isoform B", "tax_id": 7227, "disease": "exudative vitreoretinopathy (Disease Ontology:DOID:0050535); exudative vitreoretinopathy 5 (Disease Ontology:DOID:0111408)", "pathway": " (dme:Dmel_CG11415)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;10731137;12537572;26848177", "class_list": "", "function": "Required for assembly of smooth septate junctions (sSJs), together with Ssk and mesh. Important for barrier function of the midgut epithelium., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016327 apicolateral plasma membrane;GO:0005920 smooth septate junction", "go_biological_process": "GO:0061028 establishment of endothelial barrier;GO:0008347 glial cell migration;GO:0090528 smooth septate junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O46101-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O46108-1", "uniprot_id": [ { "id": "LIP3_DROME", "url": "https://www.uniprot.org/uniprot/O46108", "type": "external" } ], "mass": 44901.0, "length": 394, "protein_name": "Lipase 3", "gene_name": "Lip3", "organism": "Fruit fly", "refseq_name": "lipase 3", "refseq_ac": [ { "id": "NP_477331", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477331", "type": "external" } ], "gene_names_uniprotkb": "Lip3; CG8823", "gene_names_refseq": "CG8823; Dmel\\CG8823; Dmlip3; LIP3Dm; LIP3; Lip3; dLip3; lip3", "protein_names_uniprotkb": "Lipase 3; 3.1.1.-; DmLip3", "protein_names_refseq": "CG8823-PA; Lip3-PA; Lipase-3; dLipase-3; lipase 3; lipase3", "tax_id": 7227, "disease": "autosomal recessive congenital ichthyosis 8 (Disease Ontology:DOID:0060717); lysosomal acid lipase deficiency (Disease Ontology:DOID:0080217); Wolman disease (Disease Ontology:DOID:14497); cholesterol ester storage disease (Disease Ontology:DOID:14502)", "pathway": " (dme:Dmel_CG8823); (R-DME-192456); (R-DME-6809371)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10731132;12537572;9566193", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4V3U9", "ec_number_list": [ { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0016298 lipase activity;GO:0004620 phospholipase activity;GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O46108-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O61443-1", "uniprot_id": [ { "id": "MK38B_DROME", "url": "https://www.uniprot.org/uniprot/O61443", "type": "external" } ], "mass": 42098.0, "length": 365, "protein_name": "Mitogen-activated protein kinase p38b", "gene_name": "p38b", "organism": "Fruit fly", "refseq_name": "p38b MAP kinase", "refseq_ac": [ { "id": "NP_477361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477361", "type": "external" } ], "gene_names_uniprotkb": "p38b; CG7393", "gene_names_refseq": "186F5S; BG:DS00797.3; CG7393; D-p38 MAPK; D-p38b; D-p38; Dm p38b; Dmel\\CG7393; Dmp38b; Dp38b; Dp38; ESTS:186F5S; MAPK; Mpk34C; P38B; P38; anon-sts23; dp38b; p38 MAPK; p38 MPK2b; p38 beta; p38B; p38Kb; p38MAPK; p38[MAPK]; p38beta; p38b; p38", "protein_names_uniprotkb": "Mitogen-activated protein kinase p38b; 2.7.11.24; MAP kinase p38b; MAPK p38b", "protein_names_refseq": "CG7393-PA; p38 MAP kinase; p38 mitogen-activated protein kinase; p38b MAP kinase; p38b-PA; stress-activated p38b MAP kinase", "tax_id": 7227, "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); Alzheimer's disease (Disease Ontology:DOID:10652); osteoporosis (Disease Ontology:DOID:11476); interstitial cystitis (Disease Ontology:DOID:13949); Parkinson's disease (Disease Ontology:DOID:14330); rectum cancer (Disease Ontology:DOID:1993); colon cancer (Disease Ontology:DOID:219); gastric adenocarcinoma (Disease Ontology:DOID:3717); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); nasopharynx carcinoma (Disease Ontology:DOID:9261); diabetic neuropathy (Disease Ontology:DOID:9743)", "pathway": " (dme:Dmel_CG7393); (R-DME-168638); (R-DME-171007); (R-DME-198753); (R-DME-2559580); (R-DME-418592); (R-DME-4420097); (R-DME-450302); (R-DME-450341); (R-DME-525793); (R-DME-5675221); (R-DME-6798695); (R-DME-69601); (R-DME-9824585)", "pathway_count": 14, "publication_count": 7, "publication_id_list": "10022918;10471707;10731132;12537569;12537572;18327897;9584193", "class_list": "", "function": "Kinase involved in dpp signal transduction pathway in the process of wing morphogenesis when the levels of dpp are enhanced or inhibited. May down-regulate insect immunity gene expression after prolonged infection., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "5.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.-", "type": "external" }, { "id": "3.2.1.31", "url": 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"https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "5.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "1.11.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.-", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004707 MAP kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:2000331 regulation of terminal button organization;GO:0006955 immune response;GO:0035556 intracellular signal transduction;GO:0042594 response to starvation;GO:0000165 MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O61443-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O62619-1", "uniprot_id": [ { "id": "KPYK_DROME", "url": "https://www.uniprot.org/uniprot/O62619", "type": "external" } ], "mass": 57440.0, "length": 533, "protein_name": "Pyruvate kinase", "gene_name": "Pyk", "organism": "Fruit fly", "refseq_name": "pyruvate kinase, isoform A", "refseq_ac": [ { "id": "NP_524448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524448", "type": "external" } ], "gene_names_uniprotkb": "Pyk; CG7070", "gene_names_refseq": "CG7070; Dmel\\CG7070; PKM; PK; PYK; Pk; PyK; Pyk; cg7070; l(3)rQ178; l(3)r[Q178]", "protein_names_uniprotkb": "Pyruvate kinase; 2.7.1.40; PK", "protein_names_refseq": "CG7070-PA; PyK-PA; lethal (3) rQ178; pyruvate kinase, isoform A; pyruvate kinase", "tax_id": 7227, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); congenital nonspherocytic hemolytic anemia 2 (Disease Ontology:DOID:0111077); hypertension (Disease Ontology:DOID:10763); malaria (Disease Ontology:DOID:12365); Gaucher's disease (Disease Ontology:DOID:1926); congenital nonspherocytic hemolytic anemia (Disease Ontology:DOID:2861); hyperglycemia (Disease Ontology:DOID:4195); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dme:Dmel_CG7070); (R-DME-6798695); (R-DME-70171); (R-DME-70268); (R-DME-9861718)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;15952742;26235423;3920304", "class_list": "", "function": "Enzyme of the glycolytic pathway (Probable). Glycolysis is essential in glial cells but not in neurons; neurons rely on the citric acid cycle for their energy needs, and on lactate and alanine secreted into the hemolymph by glial cells to fuel it (PubMed:26235423)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, 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"2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "5.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": 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"2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0030955 potassium ion binding;GO:0004743 pyruvate kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0043186 P granule", "go_biological_process": "GO:0042866 pyruvate biosynthetic process;GO:0042593 glucose homeostasis;GO:0006096 glycolytic process;GO:0061621 canonical glycolysis;GO:0009744 response to sucrose", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O62619-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O76464-1", "uniprot_id": [ { "id": "NFT1_DROME", "url": "https://www.uniprot.org/uniprot/O76464", "type": "external" } ], "mass": 52232.0, "length": 460, "protein_name": "Nitrilase and fragile histidine triad fusion protein NitFhit", "gene_name": "NitFhit", "organism": "Fruit fly", "refseq_name": "nitrilase and fragile histidine triad fusion protein", "refseq_ac": [ { "id": "NP_525122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525122", "type": "external" } ], "gene_names_uniprotkb": "NitFhit; CG7067", "gene_names_refseq": "CG7067; Dmel\\CG7067; NitFhit; dNitFhit", "protein_names_uniprotkb": "Nitrilase and fragile histidine triad fusion protein NitFhit; AP3A hydrolase; AP3Aase; Diadenosine 5',5'''-P1,P3-triphosphate hydrolase; Dinucleosidetriphosphatase; NFT-1 protein", "protein_names_refseq": "CG7067-PA; NitFhit-PA; NitFlit; nitrilase and fragile histidine triad fusion protein", "tax_id": 7227, "disease": "brain small vessel disease 4 (Disease Ontology:DOID:0061234)", "pathway": " (dme:Dmel_CG7067)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;9671749", "class_list": "", "function": "Cleaves A-5'-PPP-5'A to yield AMP and ADP., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.-.-", "type": "external" }, { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" } ], "go_molecular_function": "GO:0000166 nucleotide binding;GO:0047710 bis(5'-adenosyl)-triphosphatase activity;GO:0110050 deaminated glutathione amidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006139 nucleobase-containing compound metabolic process;GO:0043605 amide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O76464-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O76902-1", "uniprot_id": [ { "id": "PKHF1_DROME", "url": "https://www.uniprot.org/uniprot/O76902", "type": "external" } ], "mass": 34219.0, "length": 316, "protein_name": "Pleckstrin homology domain-containing family F member 1 homolog", "gene_name": "rush", "organism": "Fruit fly", "refseq_name": "rush hour, isoform B", "refseq_ac": [ { "id": "NP_001284784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284784", "type": "external" } ], "gene_names_uniprotkb": "rush; CG14782; EG:80H7.5", "gene_names_refseq": "CG14782; Dmel\\CG14782; EG:80H7.5; rush", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family F member 1 homolog; PH domain-containing family F member 1 homolog; Protein rush hour", "protein_names_refseq": "CG14782-PB; rush hour, isoform B; rush hour; rush-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14782)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;11337470;12537569;12537572;22160599", "class_list": "", "function": "Functions in the regulation of endosome morphology and late endosome formation. Has a role in controlling trafficking from early to late endosomes and from late endosomes to lysosomes. Important for localization of Gdi to the endosomal membranes. May function in controlling the activity of multiple regulators in the endocytic pathway, perhaps by positively controlling those involved in the early steps of endocytosis such as Rab5 and hrs, and negative regulating those involved in the late stages of endocytosis like car and VhaSFD., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q95RM3", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005938 cell cortex;GO:0016324 apical plasma membrane;GO:0005770 late endosome;GO:0010008 endosome membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0007032 endosome organization;GO:0008333 endosome to lysosome transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O76902-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O76908-1", "uniprot_id": [ { "id": "VILYA_DROME", "url": "https://www.uniprot.org/uniprot/O76908", "type": "external" } ], "mass": 27450.0, "length": 237, "protein_name": "RING finger protein vilya", "gene_name": "vilya", "organism": "Fruit fly", "refseq_name": "vilya", "refseq_ac": [ { "id": "NP_570026", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570026", "type": "external" } ], "gene_names_uniprotkb": "vilya; CG2709", "gene_names_refseq": "CG2709; Dmel\\CG2709; EG:95B7.5; Vilya; mei-826; vilya", "protein_names_uniprotkb": "RING finger protein vilya", "protein_names_refseq": "CG2709-PA; meiotic 826; vilya-PA; vilya", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2709)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;10731137;12537572;26452093;30615609", "class_list": "", "function": "Required for the formation of DNA double-strand breaks during meiosis together with narya and nenya., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019789 SUMO transferase activity", "go_cellular_component": "GO:0000801 central element;GO:0035861 site of double-strand break;GO:0005694 chromosome;GO:0005713 recombination nodule;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0007143 female meiotic nuclear division;GO:0007129 homologous chromosome pairing at meiosis;GO:0007131 reciprocal meiotic recombination;GO:1903343 positive regulation of meiotic DNA double-strand break formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O76908-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77215-1", "uniprot_id": [ { "id": "UNC4_DROME", "url": "https://www.uniprot.org/uniprot/O77215", "type": "external" } ], "mass": 61123.0, "length": 588, "protein_name": "Homeobox protein unc-4", "gene_name": "unc-4", "organism": "Fruit fly", "refseq_name": "unc-4, isoform B", "refseq_ac": [ { "id": "NP_001285389", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285389", "type": "external" } ], "gene_names_uniprotkb": "unc-4; CG6269; DPHD-1; Dmel\\CG6269; Dmel_CG6269; Dunc-4; Unc-4; Unc4", "gene_names_refseq": "CG6269; DPHD-1; Dmel\\CG6269; Dunc-4; Unc-4; Unc4; unc-4", "protein_names_uniprotkb": "Homeobox protein unc-4; DPHD-1; Paired-like homeodomain protein unc-4", "protein_names_refseq": "CG6269-PB; paired HomeoDomain 1; unc-4, isoform B; unc-4-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6269)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;9857963", "class_list": "", "function": "Transcription factor that regulates synaptic specificity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q058S3", "ec_number_list": [], "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O77215-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77410-1", "uniprot_id": [ { "id": "EIF3E_DROME", "url": "https://www.uniprot.org/uniprot/O77410", "type": "external" } ], "mass": 51162.0, "length": 435, "protein_name": "Eukaryotic translation initiation factor 3 subunit E", "gene_name": "eIF3e", "organism": "Fruit fly", "refseq_name": "eukaryotic translation initiation factor 3 subunit e", "refseq_ac": [ { "id": "NP_477385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477385", "type": "external" } ], "gene_names_uniprotkb": "eIF3e; CG9677; Int6; eIF-3p48; eIF3-S6", "gene_names_refseq": "BcDNA.GM01233; BcDNA:GM01233; CG9677; DINT6; Dmel\\CG9677; Int6; eIF-3p48/INT-6; eIF3-S6; eIF3-p48/INT6; eIF3e; l(3)10547; l(3)j9E8", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit E; Eukaryotic translation initiation factor 3 subunit 6; eIF3e", "protein_names_refseq": "CG9677-PA; Int6 homologue; Int6; eIF3e-PA; eukaryotic translation initiation factor 3 subunit e", "tax_id": 7227, "disease": "intermittent claudication (Disease Ontology:DOID:3669)", "pathway": " (dme:Dmel_CG9677); (R-DME-156827); (R-DME-72649); (R-DME-72689); (R-DME-72695); (R-DME-72702)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "10375641;10731132;10731138;12537572;18493598;23716590;28505193", "class_list": "", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (PubMed:18493598). In addition to its role in the eIF-3 complex, also functions in protein ubiquitination and degradation (PubMed:18493598, PubMed:28505193). During mitosis required for regulating mitotic microtubule growth and kinetochore formation, and consequently is required for satisfying the spindle assembly checkpoint (SAC) during metaphase to prevent delays in mitotic progression (PubMed:28505193). This is likely by promoting the ubiquitination and degradation of Klp67A, a kinesin-like protein that suppresses microtubule polymerization at plus ends (PubMed:28505193). Acts in the COP9 signalosome (CSN) mediated regulation of cullin neddylation by promoting Cul1 and Cul3 neddylation and negatively regulating the CSN complex subunit CSN5 (PubMed:18493598)., [UniProtKB, PubMed, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VVA2", "ec_number_list": [], "go_molecular_function": "GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex", "go_biological_process": "GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O77410-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77459-1", "uniprot_id": [ { "id": "KEN_DROME", "url": "https://www.uniprot.org/uniprot/O77459", "type": "external" } ], "mass": 67033.0, "length": 601, "protein_name": "Transcription factor Ken", "gene_name": "ken", "organism": "Fruit fly", "refseq_name": "ken and barbie", "refseq_ac": [ { "id": "NP_523833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523833", "type": "external" } ], "gene_names_uniprotkb": "ken; CG5575", "gene_names_refseq": "2970; 3907; 5029; 8253; BCL-6/KEN; CG5575; Dmel\\CG5575; KEN; Ken; P420; ken; l(2)00628; l(2)02970; l(2)05029; okina; ok", "protein_names_uniprotkb": "Transcription factor Ken; Protein Ken and Barbie", "protein_names_refseq": "CG5575-PA; Ken & barbie; ken and barbie; ken-PA; ken-and-barbie", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5575); (R-DME-210671); (R-DME-9933946); (R-DME-9934037)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10191082;10349629;10731132;10805787;11390354;11504941;12537569;12537572;14518006;15659391;16401426;9388184;9770450", "class_list": "", "function": "Transcription factor required for terminalia development. Negative regulator of the JAK/STAT pathway: represses JAK/STAT-dependent expression of ventral veins lacking (vvl) in the posterior spiracles., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0030540 female genitalia development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0030539 male genitalia development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "O77459-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O96690-1", "uniprot_id": [ { "id": "PDF_DROME", "url": "https://www.uniprot.org/uniprot/O96690", "type": "external" } ], "mass": 11545.0, "length": 102, "protein_name": "Protein PDF", "gene_name": "Pdf", "organism": "Fruit fly", "refseq_name": "Pigment-dispersing factor", "refseq_ac": [ { "id": "NP_524517", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524517", "type": "external" } ], "gene_names_uniprotkb": "Pdf; CG6496", "gene_names_refseq": "BcDNA:RH08487; CG6496; Dmel\\CG6496; Drm-PDF; Drm-PDH; Drm-pdf; PAP; PDF C7; PDF; PDH; Pdf; anon-WO0140519.261; anon-WO0140519.3; cPDH; pdf", "protein_names_uniprotkb": "Protein PDF; Pigment-dispersing factor homolog", "protein_names_refseq": "CG6496-PA; PDF-associated peptide; PDF-precursor PDF-associated peptide; PIGMENT DISPERSING FACTOR; Pdf-PA; Pigment-dispersing factor; Pigment-dispersing hormone-like peptide; pigment dispersing hormone; pigment dispersion factor; pigment-dispersing hormone", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6496)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10619432;10725392;10731132;10777797;12537569;12537572;15356209;19038223;19230663;21214272;36786215;9615286", "class_list": "", "function": "Neuropeptide PDF is the main transmitter regulating circadian locomotor rhythms. Required to maintain behavioral rhythms under constant conditions by coordinating pacemaker interactions in the circadian system (PubMed:10619432, PubMed:10777797, PubMed:15356209). Together with CCHa1, involved in regulating intensity and periodicity of daytime activity, possibly by modulating rhythmic expression of circadian protein PER/period in a subset of clock neurons, but not TIM/timeless (PubMed:36786215). Acts on small and large ventral lateral neurons to control sleep and regulates the state transition from sleep to wake (PubMed:19038223, PubMed:19230663)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7JYY1;Q9VBE9", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0043025 neuronal cell body;GO:0043005 neuron projection", "go_biological_process": "GO:1904059 regulation of locomotor rhythm;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0007617 mating behavior;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O96690-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O96989-1", "uniprot_id": [ { "id": "O96989_DROME", "url": "https://www.uniprot.org/uniprot/O96989", "type": "external" } ], "mass": 65891.0, "length": 575, "protein_name": "Cell division cycle 45", "gene_name": "Cdc45", "organism": "Fruit fly", "refseq_name": "cell division cycle 45", "refseq_ac": [ { "id": "NP_569880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569880", "type": "external" } ], "gene_names_uniprotkb": "Cdc45; CDC45L; CDC45; CG3658; DmCdc45; Dmel\\CG3658; Dmel_CG3658; D; EG:BACR7A4.11; anon-1Ec; cdc45; dCDC45L; dCDC45", "gene_names_refseq": "CDC45L; CDC45; CG3658; Cdc45; DmCdc45; Dmel\\CG3658; D; EG:BACR7A4.11; anon-1Ec; cdc45; dCDC45L; dCDC45", "protein_names_uniprotkb": "Cell division cycle 45", "protein_names_refseq": "CDC45L; CG3658-PA; Cdc45-PA; cell division cycle 45; transcription unit D", "tax_id": 7227, "disease": "Meier-Gorlin syndrome (Disease Ontology:DOID:0060306); chromosome 22q11.2 deletion syndrome, distal (Disease Ontology:DOID:0060413); Meier-Gorlin syndrome 7 (Disease Ontology:DOID:0080518)", "pathway": " (dme:Dmel_CG3658); (R-DME-176187); (R-DME-68962)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;31484077", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0003682 chromatin binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0031261 DNA replication preinitiation complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0071162 CMG complex", "go_biological_process": "GO:1902977 mitotic DNA replication preinitiation complex assembly;GO:0051301 cell division;GO:0006260 DNA replication;GO:0030261 chromosome condensation;GO:0006270 DNA replication initiation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "O96989-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O97125-1", "uniprot_id": [ { "id": "HSP68_DROME", "url": "https://www.uniprot.org/uniprot/O97125", "type": "external" } ], "mass": 69744.0, "length": 635, "protein_name": "Heat shock protein 68", "gene_name": "Hsp68", "organism": "Fruit fly", "refseq_name": "heat shock protein 68", "refseq_ac": [ { "id": "NP_524474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524474", "type": "external" } ], "gene_names_uniprotkb": "Hsp68; CG5436", "gene_names_refseq": "68; CG5436; DmHsp68; Dmel\\CG5436; HSP68_DROME; HSP68; HSP70cA7; Hsp-68; Hsp68; hsp68", "protein_names_uniprotkb": "Heat shock protein 68", "protein_names_refseq": "70 kDa heat shock protein, cytosolic A 7; CG5436-PA; Hsp 68; Hsp68-PA; heat shock protein 68", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5436)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18327897", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0042594 response to starvation;GO:0042026 protein refolding;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O97125-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O97143-1", "uniprot_id": [ { "id": "PLK4_DROME", "url": "https://www.uniprot.org/uniprot/O97143", "type": "external" } ], "mass": 85887.0, "length": 769, "protein_name": "Serine/threonine-protein kinase PLK4", "gene_name": "SAK", "organism": "Fruit fly", "refseq_name": "Sak kinase", "refseq_ac": [ { "id": "NP_649324", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649324", "type": "external" } ], "gene_names_uniprotkb": "SAK; CG7186", "gene_names_refseq": "CG7186; DSak; DmPLK4; DmPlk4; DmSAK; Dmel\\CG7186; PLK4; Plk4; SAK/PLK4; SAK/PLK; SAK/Plk4; SAK; Sak/PLK4; Sak/Plk4; Sak; plk4; sak", "protein_names_uniprotkb": "Serine/threonine-protein kinase PLK4; 2.7.11.21; PLK-4; Polo-like kinase 4; Serine/threonine-protein kinase SAK", "protein_names_refseq": "CG7186-PA; Polo-like kinase 4; SAK-PA; Sak kinase", "tax_id": 7227, "disease": "ciliopathy (Disease Ontology:DOID:0060340); microcephaly and chorioretinopathy 2 (Disease Ontology:DOID:0080106); colon cancer (Disease Ontology:DOID:219); breast ductal carcinoma (Disease Ontology:DOID:3007); hepatocellular carcinoma (Disease Ontology:DOID:684); diabetic retinopathy (Disease Ontology:DOID:8947)", "pathway": " (dme:Dmel_CG7186)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10731132;12537572;16326102;17463247;18555779;19084407;19171756;20946984;24184097", "class_list": "", "function": "Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as Sas-6. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Centrosome amplification following overexpression can initiate tumorigenesis, highlighting the importance of centrosome regulation in cancers., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86NL8", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005814 centriole", "go_biological_process": "GO:0031647 regulation of protein stability;GO:0045732 positive regulation of protein catabolic process;GO:0007140 male meiotic nuclear division;GO:0007098 centrosome cycle;GO:0046599 regulation of centriole replication", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "O97143-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O97172-1", "uniprot_id": [ { "id": "U729_DROME", "url": "https://www.uniprot.org/uniprot/O97172", "type": "external" } ], "mass": 11150.0, "length": 99, "protein_name": "UPF0729 protein CG18508", "gene_name": "CG18508", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001284836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284836", "type": "external" } ], "gene_names_uniprotkb": "CG18508", "gene_names_refseq": "CG18508; CG4015; Dmel\\CG18508; EG:140G11.3", "protein_names_uniprotkb": "UPF0729 protein CG18508", "protein_names_refseq": "CG18508-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18508)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;10731137;12537572;16020794;18327897", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32UZ2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O97172-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O97477-1", "uniprot_id": [ { "id": "INO1_DROME", "url": "https://www.uniprot.org/uniprot/O97477", "type": "external" } ], "mass": 62249.0, "length": 565, "protein_name": "Inositol-3-phosphate synthase", "gene_name": "Inos", "organism": "Fruit fly", "refseq_name": "myo-inositol-1-phosphate synthase", "refseq_ac": [ { "id": "NP_477405", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477405", "type": "external" } ], "gene_names_uniprotkb": "Inos; CG11143", "gene_names_refseq": "CG11143; Dmel\\CG11143; INOS; Inos; bs36h12.y1", "protein_names_uniprotkb": "Inositol-3-phosphate synthase; 5.5.1.4; IPS; MI-1-P synthase; MIP synthase; Myo-inositol 1-phosphate synthase", "protein_names_refseq": "CG11143-PA; Inos-PA; myo-inositol-1-phosphate synthase; myo-inositol-1-phosphate-synthase", "tax_id": 7227, "disease": "acquired metabolic disease (Disease Ontology:DOID:0060158); azoospermia (Disease Ontology:DOID:14227)", "pathway": " (dme:Dmel_CG11143); (R-DME-1855183)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10731132;11121586;12537569;12537572;15952742;17372656", "class_list": "", "function": "Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner (PubMed:11121586). Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IGW1;Q8MR42", "ec_number_list": [ { "id": "5.5.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.5.1.4", "type": "external" } ], "go_molecular_function": "GO:0004512 inositol-3-phosphate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006021 inositol biosynthetic process;GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O97477-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02515-1", "uniprot_id": [ { "id": "HSP22_DROME", "url": "https://www.uniprot.org/uniprot/P02515", "type": "external" } ], "mass": 19763.0, "length": 174, "protein_name": "Heat shock protein 22", "gene_name": "Hsp22", "organism": "Fruit fly", "refseq_name": "heat shock protein 22, isoform B", "refseq_ac": [ { "id": "NP_001027114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027114", "type": "external" } ], "gene_names_uniprotkb": "Hsp22; CG4460", "gene_names_refseq": "22; CG32041; CG4460; DmHsp22; Dmel20.8; Dmel\\CG4460; EP(3)3247; HSP22; Hsp22; anon-WO0118547.50; anon-WO0140519.138; dHSP22; dHsp22; hsp22; small hsp locus 67B", "protein_names_uniprotkb": "Heat shock protein 22", "protein_names_refseq": "CG4460-PB; Hsp22-PB; heat shock protein 22, isoform B; heat shock protein 22; heat shock protein hsp22; heat-shock protein 22", "tax_id": 7227, "disease": "adult-onset myofibrillar myopathy 2A (Disease Ontology:DOID:0080093); infantile-onset myofibrillar myopathy-2B (Disease Ontology:DOID:0080309); cataract 16 multiple types (Disease Ontology:DOID:0110250); cataract 9 multiple types (Disease Ontology:DOID:0110266); dilated cardiomyopathy 1II (Disease Ontology:DOID:0110450); neurodegenerative disease (Disease Ontology:DOID:1289); macular degeneration (Disease Ontology:DOID:4448); cataract (Disease Ontology:DOID:83); ocular hypertension (Disease Ontology:DOID:9282); galactosemia (Disease Ontology:DOID:9870)", "pathway": " (dme:Dmel_CG4460); (R-DME-3371571)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;17372656;6285380;6302284", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 10, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V1Q5;Q95SZ4;Q9VSX1", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051082 unfolded protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0006457 protein folding;GO:0009408 response to heat;GO:0042026 protein refolding;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P02515-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02517-1", "uniprot_id": [ { "id": "HSP26_DROME", "url": "https://www.uniprot.org/uniprot/P02517", "type": "external" } ], "mass": 22994.0, "length": 208, "protein_name": "Heat shock protein 26", "gene_name": "Hsp26", "organism": "Fruit fly", "refseq_name": "heat shock protein 26, isoform B", "refseq_ac": [ { "id": "NP_001287000", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287000", "type": "external" } ], "gene_names_uniprotkb": "Hsp26; 26K; 26; CG4183; DmHsp26; Dmel23.0; Dmel\\CG4183; Dmel_CG4183; HSP26; Hsp 26; hsp 26; hsp26; small hsp locus 67B", "gene_names_refseq": "26K; 26; CG4183; DmHsp26; Dmel23.0; Dmel\\CG4183; HSP26; Hsp 26; Hsp26; hsp 26; hsp26; small hsp locus 67B", "protein_names_uniprotkb": "Heat shock protein 26", "protein_names_refseq": "CG4183-PB; Hsp 26; Hsp26-PB; heat shock protein 26, isoform B; heat shock protein 26; heat shock protein hsp26", "tax_id": 7227, "disease": "adult-onset myofibrillar myopathy 2A (Disease Ontology:DOID:0080093); infantile-onset myofibrillar myopathy-2B (Disease Ontology:DOID:0080309); cataract 16 multiple types (Disease Ontology:DOID:0110250); cataract 9 multiple types (Disease Ontology:DOID:0110266); dilated cardiomyopathy 1II (Disease Ontology:DOID:0110450); macular degeneration (Disease Ontology:DOID:4448); cataract (Disease Ontology:DOID:83); ocular hypertension (Disease Ontology:DOID:9282); galactosemia (Disease Ontology:DOID:9870)", "pathway": " (dme:Dmel_CG4183); (R-DME-3371571)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;6285380;6302284", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VSX3", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0017022 myosin binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006457 protein folding;GO:0009631 cold acclimation;GO:0009408 response to heat;GO:0042026 protein refolding;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P02517-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02518-1", "uniprot_id": [ { "id": "HSP27_DROME", "url": "https://www.uniprot.org/uniprot/P02518", "type": "external" } ], "mass": 23617.0, "length": 213, "protein_name": "Heat shock protein 27", "gene_name": "Hsp27", "organism": "Fruit fly", "refseq_name": "heat shock protein 27, isoform B", "refseq_ac": [ { "id": "NP_001287001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287001", "type": "external" } ], "gene_names_uniprotkb": "Hsp27; 26; 27K; 27; 28; CG4466; Dhsp27; DmHSP27; DmHsp27; Dmel23.6; Dmel\\CG4466; Dmel_CG4466; HSP27; HSP28; Hsp 27; Hsp28; anon-WO0140519.69; dHSP27; hsp 27; hsp-27; hsp26; hsp27; hsp28; small hsp locus 67B", "gene_names_refseq": "27K; 27; 28; CG4466; Dhsp27; DmHSP27; DmHsp27; Dmel23.6; Dmel\\CG4466; HSP27; HSP28; Hsp 27; Hsp27; Hsp28; anon-WO0140519.69; dHSP27; hsp 27; hsp-27; hsp26; hsp27/26; hsp27; hsp28; small hsp locus 67B", "protein_names_uniprotkb": "Heat shock protein 27", "protein_names_refseq": "CG4466-PB; Hsp 27; Hsp27-PB; heat shock protein 237; heat shock protein 27, isoform B; heat shock protein 27; heat shock protein hsp27; heatshock protein 27", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4466); (R-DME-3371571)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17372656;17569856;17569867;18327897;25589440;26109356;26109357;28520783;6285380;6302284", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VSX6", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0042595 behavioral response to starvation;GO:0006457 protein folding;GO:0042742 defense response to bacterium;GO:0009408 response to heat;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P02518-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02825-1", "uniprot_id": [ { "id": "HSP71_DROME", "url": "https://www.uniprot.org/uniprot/P02825", "type": "external" } ], "mass": 70160.0, "length": 642, "protein_name": "Heat shock 70 kDa protein Ab", "gene_name": "Hsp70Ab", "organism": "Fruit fly", "refseq_name": "heat shock protein 70 Ab", "refseq_ac": [ { "id": "NP_524798", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524798", "type": "external" } ], "gene_names_uniprotkb": "Hsp70Ab; CG18743; Hsp70A", "gene_names_refseq": "87A7 hsp70; CG18743; DMHSP7A2; Dm-hsp70; Dmel\\CG18743; GRP78; HSP70Ab; HSP70cA2; HSP70; Hsp 70; Hsp-70; Hsp70-Ab; Hsp70Ab; Hsp70A; Hsp70aB; Hsp70ab; Hsp70b; Hsp70; dHsp70; dhsp70; hs70; hsp 70; hsp-70; hsp70 87A; hsp70(87A); hsp70Ab; hsp70A; hsp70a; hsp70", "protein_names_uniprotkb": "Heat shock 70 kDa protein Ab; HSP70-87A7; Heat shock protein 70 Ab", "protein_names_refseq": "70 kDa heat shock protein, cytosolic A 2; 87A locus; CG18743-PA; Heat-shock-protein-70Ab; Hsp70Ab-PA; heat shock 70; heat shock protein 70 Ab; heat shock protein 70Ab; heat-shock protein 70", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18743); (dme:Dmel_CG31366)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "10731132;11493638;11965431;12537572;18344983;18614012;22178397;6255408;6795353;6804941", "class_list": "", "function": "Stress-response chaperone protein that prevents toxic aggregation of proteins., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q95NG7", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0001666 response to hypoxia;GO:0009408 response to heat;GO:0042026 protein refolding;GO:0006986 response to unfolded protein;GO:0035080 heat shock-mediated polytene chromosome puffing", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P02825-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02836-1", "uniprot_id": [ { "id": "HMEN_DROME", "url": "https://www.uniprot.org/uniprot/P02836", "type": "external" } ], "mass": 59411.0, "length": 552, "protein_name": "Segmentation polarity homeobox protein engrailed", "gene_name": "en", "organism": "Fruit fly", "refseq_name": "engrailed, isoform A", "refseq_ac": [ { "id": "NP_523700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523700", "type": "external" } ], "gene_names_uniprotkb": "en; CG9015", "gene_names_refseq": "153867_at; Apa; CG9015; Dmel\\CG9015; EN; EnR; Engrailed/Invected; Engrailed; Engr; Eng; En; Es; V; en1; en; spa2; spt", "protein_names_uniprotkb": "Segmentation polarity homeobox protein engrailed", "protein_names_refseq": "CG9015-PA; ENGRAILED; apigmented abdomen; en-PA; engrailed, isoform A; erased; invected; sparse SGPs 2; spermatheca; transcript group V; vasodilator-stimulated phosphoprotein", "tax_id": 7227, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autistic disorder (Disease Ontology:DOID:12849); Parkinson's disease (Disease Ontology:DOID:14330)", "pathway": " (dme:Dmel_CG9015)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;10889025;12537569;12537572;1335365;1977522;2481829;2899884;3917855;3935318;8334991;9309220;9813123", "class_list": "", "function": "This protein specifies the body segmentation pattern. It is required for the development of the central nervous system. Transcriptional regulator that represses activated promoters. Wg signaling operates by inactivating the SGG repression of EN autoactivation., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P02837;Q0E9C0;Q24356;Q9V601", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007418 ventral midline development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P02836-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02843-1", "uniprot_id": [ { "id": "VIT1_DROME", "url": "https://www.uniprot.org/uniprot/P02843", "type": "external" } ], "mass": 48712.0, "length": 439, "protein_name": "Vitellogenin-1", "gene_name": "Yp1", "organism": "Fruit fly", "refseq_name": "yolk protein 1, isoform B", "refseq_ac": [ { "id": "NP_001285071", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285071", "type": "external" } ], "gene_names_uniprotkb": "Yp1; CG2985; DmYP1; Dmel\\CG2985; Dmel_CG2985; VG1; VIT1Dm; YP-1; YP1; YPI; YP[[1]]; YP; fs(1)1163; fs(1)A1163; yp-1; yp1; yp", "gene_names_refseq": "CG2985; DmYP1; Dmel\\CG2985; VG1; VIT1Dm; YP-1; YP1; YPI; YP[[1]]; YP; Yp1; fs(1)1163; fs(1)A1163; yp-1; yp1; yp", "protein_names_uniprotkb": "Vitellogenin-1; Vitellogenin I; Yolk protein 1", "protein_names_refseq": "CG2985-PB; Yok protein 1; Yp1-PB; vitellogenin; yolk protein 1, isoform B; yolk protein 1; yolk protein I; yolk protein; yolk-protein 1", "tax_id": 7227, "disease": "hypotrichosis 7 (Disease Ontology:DOID:0110704)", "pathway": " (dme:Dmel_CG2985); (R-DME-192456); (R-DME-8963889); (R-DME-8964058)", "pathway_count": 4, "publication_count": 19, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;19050045;25589440;26109356;26109357;33891588;3922974;6272212;6275360;6806773", "class_list": "", "function": "Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis. Along with Yp2 and Yp3, and their receptor yl/yolkless, required for maintenance of microtubule plus-end orientation towards the posterior pole of oocytes (PubMed:33891588). Involved in polarized localization of germ plasm components, such as osk mRNA and vas protein, to the oocyte posterior cortex (PubMed:33891588). Receptor-mediated endocytosis by yl/yolkless is crucial for actin reorganization, mediated by osk isoform A/Long, required to anchor germ plasm components to the oocyte cortex (PubMed:33891588)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SXV7;Q9W2Y9", "ec_number_list": [], "go_molecular_function": "GO:0017171 serine hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031982 vesicle", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0007548 sex differentiation;GO:0032502 developmental process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P02843-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02844-1", "uniprot_id": [ { "id": "VIT2_DROME", "url": "https://www.uniprot.org/uniprot/P02844", "type": "external" } ], "mass": 49660.0, "length": 442, "protein_name": "Vitellogenin-2", "gene_name": "Yp2", "organism": "Fruit fly", "refseq_name": "yolk protein 2, isoform B", "refseq_ac": [ { "id": "NP_001285070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285070", "type": "external" } ], "gene_names_uniprotkb": "Yp2; CG2979; Dmel\\CG2979; Dmel_CG2979; VG2; VIT2Dm; YP-2; YP2; YPII; YP[[2]]; YP; fs(1)A59; fs(1)K313; fs(1)M35; fs(1)m35; yp2; yp", "gene_names_refseq": "CG2979; Dmel\\CG2979; VG2; VIT2Dm; YP-2; YP2; YPII; YP[[2]]; YP; Yp2; fs(1)A59; fs(1)K313; fs(1)M35; fs(1)m35; yp2; yp", "protein_names_uniprotkb": "Vitellogenin-2; Vitellogenin II; Yolk protein 2", "protein_names_refseq": "CG2979-PB; Yp2-PB; vitellogenin; yolk protein 2, isoform B; yolk protein 2; yolk protein", "tax_id": 7227, "disease": "hypotrichosis 7 (Disease Ontology:DOID:0110704)", "pathway": " (dme:Dmel_CG2979); (R-DME-192456); (R-DME-8963889); (R-DME-8964058)", "pathway_count": 4, "publication_count": 18, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;3139663;33891588;3922974;6405043;6806773", "class_list": "", "function": "Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis. Vitellogenins and their receptor yl/yolkless are required for maintenance of microtubule plus-end orientation towards the posterior pole of oocytes (PubMed:33891588). Involved in polarized localization of germ plasm components, such as osk mRNA and vas protein, to the oocyte posterior cortex (PubMed:33891588). Receptor-mediated endocytosis by yl/yolkless is crucial for actin reorganization, mediated by osk isoform A/Long, required to anchor germ plasm components to the oocyte cortex (PubMed:33891588)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W2Z0", "ec_number_list": [], "go_molecular_function": "GO:0017171 serine hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0007548 sex differentiation;GO:0032502 developmental process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P02844-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P03896-1", "uniprot_id": [ { "id": "NU2M_DROME", "url": "https://www.uniprot.org/uniprot/P03896", "type": "external" } ], "mass": 39823.0, "length": 341, "protein_name": "NADH-ubiquinone oxidoreductase chain 2", "gene_name": "mt:ND2", "organism": "Fruit fly", "refseq_name": "NADH dehydrogenase subunit 2", "refseq_ac": [ { "id": "YP_009047266", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_009047266", "type": "external" } ], "gene_names_uniprotkb": "mt:ND2; NADH2; ND2", "gene_names_refseq": "ND2; mt:ND2", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 2; 7.1.1.2; NADH dehydrogenase subunit 2", "protein_names_refseq": "NADH dehydrogenase subunit 2", "tax_id": 7227, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); urinary bladder cancer (Disease Ontology:DOID:11054); Parkinson's disease (Disease Ontology:DOID:14330); multiple sclerosis (Disease Ontology:DOID:2377); myocardial infarction (Disease Ontology:DOID:5844); mitochondrial metabolism disease (Disease Ontology:DOID:700); Leber hereditary optic neuropathy (Disease Ontology:DOID:705)", "pathway": " (dme:Dmel_CG34063); (R-DME-5419276); (R-DME-611105); (R-DME-6799198)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10903372;11298822;18727704;19540318;2124697;6408489;8825764", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B6E0P2;B6E0Q5;B6E0U4;Q34347;Q34348;Q9MGN7;Q9MGP1;Q9MJC9", "ec_number_list": [ { "id": "7.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.9", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" } ], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P03896-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04197-1", "uniprot_id": [ { "id": "MYB_DROME", "url": "https://www.uniprot.org/uniprot/P04197", "type": "external" } ], "mass": 74045.0, "length": 657, "protein_name": "Myb protein", "gene_name": "Myb", "organism": "Fruit fly", "refseq_name": "Myb oncogene-like, isoform A", "refseq_ac": [ { "id": "NP_511170", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_511170", "type": "external" } ], "gene_names_uniprotkb": "Myb; CG9045", "gene_names_refseq": "CG9045; D-myb; DMyb; Dm Myb; Dm myb; Dm-Myb; Dm-myb; DmMYB; DmMyb; Dmel\\CG9045; Dmyb; MYB; Myb; c-Myb; c-myb; dMyb; dmMYB; dmyb; l(1)XVI; myb; p85", "protein_names_uniprotkb": "Myb protein", "protein_names_refseq": "CG9045-PA; Myb oncogene-like, isoform A; Myb-PA", "tax_id": 7227, "disease": "adult T-cell leukemia/lymphoma (Disease Ontology:DOID:0050523); myelodysplastic syndrome (Disease Ontology:DOID:0050908); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); essential thrombocythemia (Disease Ontology:DOID:2224); transient cerebral ischemia (Disease Ontology:DOID:224); myelofibrosis (Disease Ontology:DOID:4971); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (dme:Dmel_CG9045)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;12490953;12537572;15479636;15545624;18327897;3121304;3921261", "class_list": "", "function": "DNA-binding protein that specifically recognizes the sequence 5'-YAAC[GT]G-3'. Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In follicle cells, the complex plays a central role in the site-specific DNA replication at the chorion loci. During development, the complex represses transcription of developmentally controlled E2F target genes., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VXM9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0070176 DRM complex;GO:0005634 nucleus;GO:0000791 euchromatin;GO:0031523 Myb complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0045931 positive regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P04197-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05084-1", "uniprot_id": [ { "id": "HUNB_DROME", "url": "https://www.uniprot.org/uniprot/P05084", "type": "external" } ], "mass": 83114.0, "length": 758, "protein_name": "Protein hunchback", "gene_name": "hb", "organism": "Fruit fly", "refseq_name": "hunchback, isoform A", "refseq_ac": [ { "id": "NP_731267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_731267", "type": "external" } ], "gene_names_uniprotkb": "hb; CG9786", "gene_names_refseq": "CG9786; Dm-Hb; Dm-hb; Dmel\\CG9786; HB; Hb; Hunchback; R-pbx; Rg-bx; Rg-pbx; hbHLH; hb; l(3)85Ah", "protein_names_uniprotkb": "Protein hunchback", "protein_names_refseq": "CG9786-PA; Regulator-of-postbithorax; hb-PA; hunchback, isoform A; hunchback", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9786)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;12572604;1438276;18327897;8200478", "class_list": "", "function": "Gap class segmentation protein that controls development of head structures., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q24018;Q29R06;Q960U7", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0040034 regulation of development, heterochronic;GO:0007402 ganglion mother cell fate determination;GO:0007354 zygotic determination of anterior/posterior axis, embryo;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P05084-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05812-1", "uniprot_id": [ { "id": "HSP6A_DROME", "url": "https://www.uniprot.org/uniprot/P05812", "type": "external" } ], "mass": 46931.0, "length": 445, "protein_name": "Heat shock protein 67B1", "gene_name": "Hsp67Ba", "organism": "Fruit fly", "refseq_name": "heat shock gene 67Ba", "refseq_ac": [ { "id": "NP_523998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523998", "type": "external" } ], "gene_names_uniprotkb": "Hsp67Ba; CG4167", "gene_names_refseq": "CG4167; DROHSP1; DROHSP; DmHsp67; Dmel22.2; Dmel\\CG4167; HSP67BA; Hsp-G1; Hsp67Ba; gene 1; gene1; hsp67Ba; small hsp locus 67B", "protein_names_uniprotkb": "Heat shock protein 67B1", "protein_names_refseq": "CG4167-PA; Hsp67Ba-PA; gene 1; heat shock gene 67Ba; heat shock protein family B (small) member 1", "tax_id": 7227, "disease": "adult-onset myofibrillar myopathy 2A (Disease Ontology:DOID:0080093); infantile-onset myofibrillar myopathy-2B (Disease Ontology:DOID:0080309); cataract 16 multiple types (Disease Ontology:DOID:0110250); cataract 9 multiple types (Disease Ontology:DOID:0110266); dilated cardiomyopathy 1II (Disease Ontology:DOID:0110450); macular degeneration (Disease Ontology:DOID:4448); cataract (Disease Ontology:DOID:83); ocular hypertension (Disease Ontology:DOID:9282); galactosemia (Disease Ontology:DOID:9870)", "pathway": " (dme:Dmel_CG4167); (R-DME-3371571)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537572;3933974", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q5U130;Q9VSX4", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006457 protein folding;GO:0009408 response to heat;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P05812-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06603-1", "uniprot_id": [ { "id": "TBA1_DROME", "url": "https://www.uniprot.org/uniprot/P06603", "type": "external" } ], "mass": 49908.0, "length": 450, "protein_name": "Tubulin alpha-1 chain", "gene_name": "alphaTub84B", "organism": "Fruit fly", "refseq_name": "alpha-Tubulin at 84B", "refseq_ac": [ { "id": "NP_476772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476772", "type": "external" } ], "gene_names_uniprotkb": "alphaTub84B; CG1913; tubA84B", "gene_names_refseq": "1t; ALPHA 84C; Alpha-Tubulin84B; AlphaTub84B; BEST:LD32507; CG1913; DM1alpha; DTA1; Dmel\\CG1913; FBgn0003884; TBA1_DROME; Talpha1; Tub 84B; Tub1C; Tub84B; Tuba84B; Tubalpha1; Tubulin84B; Tub; T; a-tub84B; a1t; aTub84B; alpha-Tub84B; alpha-Tub; alpha-tub84B; alpha-tubulin 84B; alpha-tubulin; alpha-tub; alpha1-tubulin; alpha1tub84B; alpha1tub; alpha1t; alpha1; alpha84B; alphaTUB84B; alphaTUB; alphaTub1; alphaTub84B; alphaTub84; alphaTubulin; alphaTub; alphaT; alphat-1; alphatub84B; alphatub84b; alphatub; anon-EST:Liang-1.59; anon-EST:Liang-2.30; chr3R:2914276..2914416; clone 1.59; clone 2.30; l(3)84Bd; l(3)g3; ms(3)nc33; nc33; tubA84B; tubalpha1; tubulin; tub", "protein_names_uniprotkb": "Tubulin alpha-1 chain; 3.6.5.-", "protein_names_refseq": "CG1913-PA; Tubulin-alpha1; alpha tubulin 84B; alpha tubulin; alpha-Tubulin 84B; alpha-Tubulin at 84B; alpha-tubulin 1; alpha-tubulin84B; alpha1 tubulin; alpha1-tubulin; alphaTub84B-PA; alphaTubulin 84B; alphaTubulin84B; alpha[[1]] tubulin; alpha[[1]]-tubulin; alphatubulin; tubulin 1 alpha-chain; tubulin 1alpha; tubulin alpha1 promoter; tubulin alpha1; tubulin(alpha1); tubulin1alpha; tubulin84B", "tax_id": 7227, "disease": "lissencephaly (Disease Ontology:DOID:0050453); autosomal dominant isolated macrothrombocytopenia 2 (Disease Ontology:DOID:0060995); polymicrogyria (Disease Ontology:DOID:0080918); lissencephaly 3 (Disease Ontology:DOID:0112232); microlissencephaly (Disease Ontology:DOID:0112234); keratoconus (Disease Ontology:DOID:10126); microcephaly (Disease Ontology:DOID:10907); Down syndrome (Disease Ontology:DOID:14250); congenital nervous system abnormality (Disease Ontology:DOID:2490)", "pathway": " (dme:Dmel_CG1913)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537572;22751930;3095837;32066907;36342916", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VI59", "ec_number_list": [ { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" } ], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000235 astral microtubule;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization;GO:0032418 lysosome localization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P06603-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06605-1", "uniprot_id": [ { "id": "TBA3_DROME", "url": "https://www.uniprot.org/uniprot/P06605", "type": "external" } ], "mass": 49890.0, "length": 450, "protein_name": "Tubulin alpha-3 chain", "gene_name": "alphaTub84D", "organism": "Fruit fly", "refseq_name": "alpha-Tubulin at 84D", "refseq_ac": [ { "id": "NP_524264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524264", "type": "external" } ], "gene_names_uniprotkb": "alphaTub84D; CG2512; TubA84D", "gene_names_refseq": "3t; 84D; ALPHA 84D; AlphaTub84D; CG2512; D.m.ALPHA-84D; DTA4; Dmel\\CG2512; FBgn0003884; Tub1A; Tub; T; aTub84D; alpha-Tub84D; alpha-Tub; alpha-tub84D; alpha-tubulin; alpha-tub; alpha3t; alpha3; alpha84D; alphaTUB84D; alphaTUB; alphaTub3; alphaTub84D; alphaTub84; alphaTub", "protein_names_uniprotkb": "Tubulin alpha-3 chain; 3.6.5.-", "protein_names_refseq": "CG2512-PA; Tubulin-alpha3; alpha tubulin; alpha-Tubulin at 84D; alpha-Tubulin; alpha-tubulin84D; alphaTub84D-PA; alphaTubulin 84D; alphatubulin; tubulin alpha-3 chain; tubulin alpha3; tubulin at 84D", "tax_id": 7227, "disease": "lissencephaly (Disease Ontology:DOID:0050453); autosomal dominant isolated macrothrombocytopenia 2 (Disease Ontology:DOID:0060995); polymicrogyria (Disease Ontology:DOID:0080918); lissencephaly 3 (Disease Ontology:DOID:0112232); microlissencephaly (Disease Ontology:DOID:0112234); keratoconus (Disease Ontology:DOID:10126); microcephaly (Disease Ontology:DOID:10907); Down syndrome (Disease Ontology:DOID:14250); congenital nervous system abnormality (Disease Ontology:DOID:2490)", "pathway": " (dme:Dmel_CG2512)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;3095837", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VIB8", "ec_number_list": [ { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" } ], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0017022 myosin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007283 spermatogenesis;GO:0000226 microtubule cytoskeleton organization;GO:0007288 sperm axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P06605-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06742-1", "uniprot_id": [ { "id": "MLC1_DROME", "url": "https://www.uniprot.org/uniprot/P06742", "type": "external" } ], "mass": 17524.0, "length": 155, "protein_name": "Myosin alkali light chain 1", "gene_name": "Mlc1", "organism": "Fruit fly", "refseq_name": "myosin alkali light chain 1, isoform D", "refseq_ac": [ { "id": "NP_001287569", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287569", "type": "external" } ], "gene_names_uniprotkb": "Mlc1; CG5596; MLC-ALK", "gene_names_refseq": "CG5596; DmMLC1; Dmel\\CG5596; ELC2; ELC_3; ELC; LC1; MLC-ALK; MLC1; MLC; Mlc-1; Mlc1; MlcI; Mlci; chr3R:23484557..23484663; mlc-alk; mlc1; mlcl; mlc; p-MLC", "protein_names_uniprotkb": "Myosin alkali light chain 1; ELC; Myosin essential light chain 1", "protein_names_refseq": "CG5596-PD; Mlc1-PD; myosin 3R alkali light chain l; myosin alkali light chain 1, isoform D; myosin alkali light chain l; myosin light Chain-1; myosin light chain 1; myosin light chain alkali", "tax_id": 7227, "disease": "hypertrophic cardiomyopathy 8 (Disease Ontology:DOID:0110314); osteoarthritis (Disease Ontology:DOID:8398)", "pathway": " (dme:Dmel_CG5596); (R-DME-445355)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10731132;12537569;12537572;2982157;3106119;31786266;6328279;7535717", "class_list": "", "function": "Non-regulatory myosin light chain component of the myosin complex (PubMed:31786266). Required for proper formation and/or maintenance of myofibers (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4LHS1;P06743;P92155;P92156;P92157;P92183;P92187;P92196;Q24380;Q24381;Q24382;Q24383;Q27304;Q27315;Q27381;Q27414;Q94988;Q9VB12", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0032036 myosin heavy chain binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005859 muscle myosin complex;GO:0005829 cytosol", "go_biological_process": "GO:0006936 muscle contraction;GO:0050790 regulation of catalytic activity;GO:0007498 mesoderm development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P06742-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07185-1", "uniprot_id": [ { "id": "CH15_DROME", "url": "https://www.uniprot.org/uniprot/P07185", "type": "external" } ], "mass": 11981.0, "length": 115, "protein_name": "Chorion protein S15", "gene_name": "Cp15", "organism": "Fruit fly", "refseq_name": "chorion protein 15", "refseq_ac": [ { "id": "NP_523979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523979", "type": "external" } ], "gene_names_uniprotkb": "Cp15; CG6519; s15", "gene_names_refseq": "C.s15; CG6519; Cp15; Cs15; Dmel\\CG6519; Dms15; E6; S15; cp15; melcp15; s-15; s15-1; s15", "protein_names_uniprotkb": "Chorion protein S15", "protein_names_refseq": "CG6519-PA; Cp15-PA; Shell-15; chorion prot 15; chorion protein 15; s15 chorion gene", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6519)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;17244601;2988878;3924529", "class_list": "", "function": "Chorion membrane (egg shell) protein; plays a role in protecting the egg from the environment., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4ULV6;A8E796;Q9VSP2", "ec_number_list": [], "go_molecular_function": "GO:0005213 structural constituent of egg chorion", "go_cellular_component": "GO:0005576 extracellular region;GO:0042600 egg chorion", "go_biological_process": "GO:0007304 chorion-containing eggshell formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P07185-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07191-1", "uniprot_id": [ { "id": "MAL2_DROME", "url": "https://www.uniprot.org/uniprot/P07191", "type": "external" } ], "mass": 64542.0, "length": 567, "protein_name": "Maltase A2", "gene_name": "Mal-A2", "organism": "Fruit fly", "refseq_name": "maltase A2", "refseq_ac": [ { "id": "NP_476625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476625", "type": "external" } ], "gene_names_uniprotkb": "Mal-A2; CG8694; LvpD", "gene_names_refseq": "CG8694; Dmel\\CG8694; Drome_A2; D; LvpD; Mal-A2; lvpD; mal_A2", "protein_names_uniprotkb": "Maltase A2; 3.2.1.20; Larval visceral protein D", "protein_names_refseq": "CG8694-PA; Mal-A2-PA; hdl cuticle gene cluster; larval visceral protein D; maltase A2; maltase", "tax_id": 7227, "disease": "cystinuria (Disease Ontology:DOID:9266)", "pathway": " (dme:Dmel_CG8694)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;6854639", "class_list": "glycogene;glycosylhydrolase", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9V4T7", "ec_number_list": [], "go_molecular_function": "GO:0004558 alpha-1,4-glucosidase activity", "go_cellular_component": "", "go_biological_process": "GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P07191-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08255-1", "uniprot_id": [ { "id": "OPS4_DROME", "url": "https://www.uniprot.org/uniprot/P08255", "type": "external" } ], "mass": 42658.0, "length": 378, "protein_name": "Opsin Rh4", "gene_name": "Rh4", "organism": "Fruit fly", "refseq_name": "rhodopsin 4", "refseq_ac": [ { "id": "NP_476701", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476701", "type": "external" } ], "gene_names_uniprotkb": "Rh4; CG9668", "gene_names_refseq": "CG9668; DMELRH4; Dm Rh4; Dmel\\CG9668; RH4; Rh4; Rh; r4; rh4", "protein_names_uniprotkb": "Opsin Rh4; Inner R7 photoreceptor cells opsin", "protein_names_refseq": "CG9668-PA; Rh4-PA; Rhodopsin4; rhodopsin 4; rhodopsin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9668)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;2952772", "class_list": "", "function": "Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9VVB3", "ec_number_list": [], "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction;GO:0071482 cellular response to light stimulus;GO:0009589 detection of UV", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P08255-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08928-1", "uniprot_id": [ { "id": "LMNB_DROME", "url": "https://www.uniprot.org/uniprot/P08928", "type": "external" } ], "mass": 71300.0, "length": 622, "protein_name": "Lamin", "gene_name": "Lam", "organism": "Fruit fly", "refseq_name": "lamin, isoform B", "refseq_ac": [ { "id": "NP_001245892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245892", "type": "external" } ], "gene_names_uniprotkb": "Lam; CG6944; egk1; misg", "gene_names_refseq": "2459; 74/76; CG6944; D5; DM[[O]]; D[[m0]]; Dm(0); Dm0; Dm1; Dm2; DmLamin; DmO; Dm[[0]]; Dm[[1]]; Dm[[2]]; Dm[[mit]]; Dm[[o]]; Dmel\\CG6944; Dmo; Dm; LAM; Lam Dm0; Lam Dm[[0]]; Lam(Dm0); LamB; LamDm0; LamDmO; LamDm[[0]]; LamDm[[o]]; LamDm; Lam[[Dm0]]; Lamin A; Lamin B; Lamin Dm0; Lamin Dm[[0]]; Lamin-B1; LaminA; LaminB; Lam; jf27; l(2)04643; l(2)25Ec; l(2)gdh-7; l(2)gdh7; l(2)jf27; lamB; lamDm0; lamDm[[0]]; lamin B; lamin Dm0; lamin DmO; lamin Dm[[0]]; lamin-B; lamin; lam; misg; nlam", "protein_names_uniprotkb": "Lamin; Lamin Dm0; Protein enhancer of glrs-klar; Protein misguided", "protein_names_refseq": "B-type lamin; CG6944-PB; Lam-PB; Lamin-B; LaminDm0; alpha-Lamin; intermediate filament-like lamina; lamin A; lamin B; lamin D[[0]]; lamin D[[m0]]; lamin D[[m]]0; lamin D[[o]]; lamin Dm0; lamin Dm[[0]]; lamin Dmo; lamin, isoform B; lethal(2)25Ec; misguided; misrouted; n-lamin; nuclear lamin", "tax_id": 7227, "disease": "arrhythmogenic right ventricular cardiomyopathy (Disease Ontology:DOID:0050431); familial partial lipodystrophy (Disease Ontology:DOID:0050440); congenital muscular dystrophy (Disease Ontology:DOID:0050557); atrioventricular block (Disease Ontology:DOID:0050820); autosomal dominant primary microcephaly 26 (Disease Ontology:DOID:0051037); autosomal dominant primary microcephaly 27 (Disease Ontology:DOID:0051038); typical adult-onset autosomal dominant demyelinating leukodystrophy (Disease Ontology:DOID:0060785); familial partial lipodystrophy type 2 (Disease Ontology:DOID:0070202); autosomal dominant Emery-Dreifuss muscular dystrophy 2 (Disease Ontology:DOID:0070247); autosomal recessive Emery-Dreifuss muscular dystrophy 3 (Disease Ontology:DOID:0070248); restrictive dermopathy 2 (Disease Ontology:DOID:0070370); partial lipodystrophy (Disease Ontology:DOID:0080299); aortic valve disease 2 (Disease Ontology:DOID:0080334); mandibuloacral dysplasia type A lipodystrophy (Disease Ontology:DOID:0081128); Charcot-Marie-Tooth disease type 2B1 (Disease Ontology:DOID:0110156); dilated cardiomyopathy 1A (Disease Ontology:DOID:0110425); congenital muscular dystrophy due to LMNA mutation (Disease Ontology:DOID:0110640); progressive myoclonus epilepsy 9 (Disease Ontology:DOID:0111450); dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome (Disease Ontology:DOID:0111584); otitis media (Disease Ontology:DOID:10754); lipoatrophic diabetes mellitus (Disease Ontology:DOID:11712); Emery-Dreifuss muscular dystrophy (Disease Ontology:DOID:11726); dilated cardiomyopathy (Disease Ontology:DOID:12930); transient cerebral ischemia (Disease Ontology:DOID:224); arteriosclerosis (Disease Ontology:DOID:2349); progeria (Disease Ontology:DOID:3911); myopathy (Disease Ontology:DOID:423); Werner syndrome (Disease Ontology:DOID:5688); cerebrovascular disease (Disease Ontology:DOID:6713); lipodystrophy (Disease Ontology:DOID:811); achalasia (Disease Ontology:DOID:9164); type 2 diabetes mellitus (Disease Ontology:DOID:9352); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (dme:Dmel_CG6944); (R-DME-352238); (R-DME-4419969); (R-DME-9035034)", "pathway_count": 4, "publication_count": 31, "publication_id_list": "10077600;10194384;10731132;11533666;12378269;12537569;12537572;14617811;15035436;15054108;1527167;15996653;16439308;18327897;18723885;2123469;21989239;22393432;22751930;2492999;27402967;3126192;7593280;8537453;8603728;8776884;8999964;9013881;9199347;9394018;9632815", "class_list": "", "function": "Component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and interacts with chromatin (PubMed:10077600, PubMed:15035436, PubMed:22393432, PubMed:3126192, PubMed:9394018). Essential for nuclear envelope assembly; required for the association of membrane vesicle nuclear envelope precursors with decondensing chromatin (PubMed:1527167). Involved in the organization and spacing of nuclear pore complexes on the nucleus surface; complements LamC (PubMed:15996653). May have a role in the localization of the LEM domain proteins Ote, bocks and MAN1 to the nuclear membrane (PubMed:15035436, PubMed:16439308). Required for uniform distribution of type-A lamin LamC within the nuclear lamina (PubMed:15996653). In spermatocytes, plays a role in maintaining LamC nuclear localization; regulates meiotic cytokinesis by maintaining the structure of the spindle envelope, and by contributing to the formation of the contractile ring and central spindle (PubMed:27402967). Required for nuclear migration and to link the microtubule organizing center (MTOC) to the nucleus (PubMed:14617811). In addition, is required for nuclear envelope localization of klar (PubMed:14617811). Maternal expression is critical for embryogenesis (PubMed:15054108). Involved in dorsal-ventral patterning in oocytes (PubMed:11533666). Required for structural organization of cytoplasmic processes during tracheal terminal branch outgrowth (PubMed:11533666). Zygotic expression is critical for late larval and pupal development (PubMed:15996653). May be involved in the nuclear localization or stability of the ecdysone receptor EcR (PubMed:15996653)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 24, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 33, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "M9NE89;Q9VMQ0", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005102 signaling receptor binding;GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005641 nuclear envelope lumen;GO:0005654 nucleoplasm", "go_biological_process": "GO:0090435 protein localization to nuclear envelope;GO:0007283 spermatogenesis;GO:0008285 negative regulation of cell population proliferation;GO:0007417 central nervous system development;GO:0048546 digestive tract morphogenesis", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P08928-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08985-1", "uniprot_id": [ { "id": "H2AV_DROME", "url": "https://www.uniprot.org/uniprot/P08985", "type": "external" } ], "mass": 14981.0, "length": 141, "protein_name": "Histone H2A.v", "gene_name": "His2Av", "organism": "Fruit fly", "refseq_name": "histone H2A variant, isoform B", "refseq_ac": [ { "id": "NP_001262997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262997", "type": "external" } ], "gene_names_uniprotkb": "His2Av; CG5499; H2AvD; His2AvD", "gene_names_refseq": "*i H2av; 5499; CG5499; Dmel\\CG5499; H2A.F/Z; H2A.V; H2A.X; H2A.Z; H2AV_DROM; H2AV; H2AX; H2AZ; H2AvD; H2Av; H2A; H2a.V; H2avD; H2av; HIS2AVD; HIS2AV; HIS; His2AV; His2AvD; His2Av; His2A; His2aV; His2av; His2; HisH2Av; Hist2av; Hist; His; P-H2Av; dHis2Av; gamma-H2AV; gamma-H2AvD; gamma-H2Av; gamma-HIS2AV; gamma-His2Av; gammaH2AV; gammaH2Av; gammaH2Ax; gammaH2ax; h2AvD; his2Av; his2av; his; l(3)05146; l(3)810; l(3)97Dd; l(3)L1602", "protein_names_uniprotkb": "Histone H2A.v; H2A.F/Z; H2A.Z", "protein_names_refseq": "CG5499-PB; His2Av-PB; Histone-2A; Histone-2av; histone 2A variant; histone H2A variant, isoform B; histone H2A variant; histone H2A.v; histone H2Av; histone variant H2Av; histone2AvD", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5499); (R-DME-212300); (R-DME-2559580); (R-DME-2559582); (R-DME-427359); (R-DME-427413); (R-DME-5578749); (R-DME-5625886); (R-DME-68616); (R-DME-73772); (R-DME-8936459); (R-DME-9018519); (R-DME-9764725); (R-DME-9841922); (R-DME-9843940); (R-DME-9909649); (R-DME-9940951); (R-DME-9943411); (R-DME-9943962)", "pathway_count": 19, "publication_count": 18, "publication_id_list": "10385122;10731132;10801889;12202754;12537569;12537572;1498368;15528408;15630020;16951084;19126864;2111857;21444826;24508391;3137528;32545538;33054831;36930688", "class_list": "", "function": "Variant histone H2A which replaces conventional H2A in a subset of nucleosomes (PubMed:1498368). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (Probable). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (Probable). DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (Probable). Acts as a Polycomb group (PcG) protein required to maintain the transcriptionally repressive state of homeotic genes of the animal throughout development (PubMed:15630020). Required for histone H3 'Lys-9' methylation and histone H4 'Lys-12' acetylation, two modifications that are essential for heterochromatin formation (PubMed:15630020). Involved in the chromatin recruitment of Parp1 and the regulation of its ADP-ribosylation activity to alter the local chromatin state in response to various stimuli, including heat shock and genotoxic stress (PubMed:21444826). Also involved in DNA double strand break (DSB) repair (PubMed:12202754). Essential for early development (PubMed:10385122)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4KH25;A0ANX7;A0ANX8;A0ANY0;A0ANY3;C0MJB2;C0MJB9;Q26252;Q540X2;Q9VBB1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0044877 protein-containing complex binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0035861 site of double-strand break;GO:0005694 chromosome;GO:0000791 euchromatin;GO:0000786 nucleosome", "go_biological_process": "GO:0006281 DNA repair;GO:0035019 somatic stem cell population maintenance;GO:0036098 male germ-line stem cell population maintenance;GO:0031507 heterochromatin formation;GO:0071168 protein localization to chromatin", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P08985-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09083-1", "uniprot_id": [ { "id": "GSBN_DROME", "url": "https://www.uniprot.org/uniprot/P09083", "type": "external" } ], "mass": 48187.0, "length": 449, "protein_name": "Protein gooseberry-neuro", "gene_name": "gsb-n", "organism": "Fruit fly", "refseq_name": "gooseberry-neuro", "refseq_ac": [ { "id": "NP_523862", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523862", "type": "external" } ], "gene_names_uniprotkb": "gsb-n; CG2692; GSBA; Gsb-p", "gene_names_refseq": "BSH-4; BSH4; CG2692; Dmel\\CG2692; GSB-N; Gsb-n; Gsb-p; GsbN; Gsbn; gsb-neuro; gsb-n; gsb-p; gsbN; gsbn; gsbp; gsb", "protein_names_uniprotkb": "Protein gooseberry-neuro; BSH4; Protein gooseberry proximal", "protein_names_refseq": "CG2692-PA; gooseberry neuro; gooseberry proximal; gooseberry-neuro; gsb proximal; gsb-n-PA; gsb-neuro; gsb-proximal", "tax_id": 7227, "disease": "neural tube defect (Disease Ontology:DOID:0080074); congenital myopathy 19 (Disease Ontology:DOID:0081351); Waardenburg syndrome type 1 (Disease Ontology:DOID:0110948); Waardenburg syndrome type 3 (Disease Ontology:DOID:0110949); craniofacial-deafness-hand syndrome (Disease Ontology:DOID:0111336); alveolar rhabdomyosarcoma (Disease Ontology:DOID:4051); Waardenburg syndrome (Disease Ontology:DOID:9258)", "pathway": " (dme:Dmel_CG2692); (R-DME-3214847)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;18327897;2877747;3123319", "class_list": "", "function": "Expressed in a segmentally repeating pattern to define the polarity of embryonic segments., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9W0W5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0022008 neurogenesis;GO:0007367 segment polarity determination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P09083-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09089-1", "uniprot_id": [ { "id": "ZEN1_DROME", "url": "https://www.uniprot.org/uniprot/P09089", "type": "external" } ], "mass": 39302.0, "length": 353, "protein_name": "Protein zerknuellt 1", "gene_name": "zen", "organism": "Fruit fly", "refseq_name": "zerknullt", "refseq_ac": [ { "id": "NP_476793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476793", "type": "external" } ], "gene_names_uniprotkb": "zen; CG1046; z1; zen1", "gene_names_refseq": "BG:DS00276.9; CG1046; Dmel\\CG1046; ZEN VRE; ZEN; Zen1; Zen; dm-zen; l(3)84Ad; z1; zen1; zen", "protein_names_uniprotkb": "Protein zerknuellt 1; ZEN-1", "protein_names_refseq": "CG1046-PA; Zen; zen-PA; zerknuellt; zerknullt 1; zerknullt; zerknult", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1046)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;2892759;40245499", "class_list": "", "function": "Required for the differentiation of the dorsal-ventral pattern, and does not appear to be involved in the process of segmentation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0IGS3;Q9VI45", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0048749 compound eye development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007378 amnioserosa formation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P09089-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C919-1", "uniprot_id": [ { "id": "MOC2A_DROME", "url": "https://www.uniprot.org/uniprot/P0C919", "type": "external" } ], "mass": 9858.0, "length": 90, "protein_name": "Molybdopterin synthase sulfur carrier subunit", "gene_name": "Mocs2A", "organism": "Fruit fly", "refseq_name": "molybdenum cofactor synthesis 2A", "refseq_ac": [ { "id": "NP_001163720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163720", "type": "external" } ], "gene_names_uniprotkb": "Mocs2A; CG42503; Mocs2", "gene_names_refseq": "CG42503; Dmel\\CG42503; Dromel_CG10238_FBtr0084782_mocs2_uORF; Mocs2A; Mocs2", "protein_names_uniprotkb": "Molybdopterin synthase sulfur carrier subunit; MOCS2A; Molybdenum cofactor synthesis protein 2 small subunit; Molybdenum cofactor synthesis protein 2A; Sulfur carrier protein MOCS2A", "protein_names_refseq": "CG42503-PA; CPuORF of FBgn0039280; Mocs2A-PA; molybdenum cofactor synthesis 2A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42503)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;18237443;29491838", "class_list": "", "function": "Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with Mocs2B, the sulfur is then transferred to precursor Z to form molybdopterin (By similarity). Involved during biosynthesis of the molybdenum cofactor (Probable)., [UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E1JIW5", "ec_number_list": [], "go_molecular_function": "GO:0000166 nucleotide binding;GO:0030366 molybdopterin synthase activity", "go_cellular_component": "GO:0005829 cytosol;GO:1990133 molybdopterin adenylyltransferase complex;GO:1990140 molybdopterin synthase complex", "go_biological_process": "GO:0006777 Mo-molybdopterin cofactor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P0C919-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10090-1", "uniprot_id": [ { "id": "WHITE_DROME", "url": "https://www.uniprot.org/uniprot/P10090", "type": "external" } ], "mass": 75673.0, "length": 687, "protein_name": "Protein white", "gene_name": "w", "organism": "Fruit fly", "refseq_name": "white", "refseq_ac": [ { "id": "NP_476787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476787", "type": "external" } ], "gene_names_uniprotkb": "w; CG2759", "gene_names_refseq": "BACN33B1.1; CG2759; DMWHITE; DmWhite; Dmel\\CG2759; EG:BACN33B1.1; White; W; c23; e(g); m(g); mini-white; mw; w(AT)[[13]]; w", "protein_names_uniprotkb": "Protein white; 7.6.2.-; 7.6.2.6; ATP-binding cassette transporter sub-family G member white; Broad substrate specificity ATP-binding cassette transporter white", "protein_names_refseq": "CG2759-PA; enhancer of garnet; mini-white; modifier of garnet; w-PA; white[+]; white", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2759)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10407069;10731132;10731137;11156992;11294610;117796;12537572;18310115;18931318;2109311;2503416;27029736;28794482;29367274;33820991;6084717;6788034;812484;8144619", "class_list": "", "function": "ATP-dependent transporter of the ATP-binding cassette (ABC) family which transports various molecules including bioamines, neurotransmitters, metabolic intermediates and second messengers (PubMed:10407069, PubMed:117796, PubMed:18310115, PubMed:18931318, PubMed:33820991, PubMed:6788034, PubMed:812484). In the eye, required for the transport of the eye red and brown pigment precursors, guanine and tryptophan, into pigment cell granules (PubMed:10407069, PubMed:8144619). Probably in association with bw/brown, involved in the transport of guanine (PubMed:117796). Probably in association with st/scarlet involved in the transport of kynurenine and probably tryptophan (PubMed:812484). Involved in the transport of kynurenine in pupal eyes (PubMed:812484). May play a role in histamine uptake by the lamina epithelial glia which surrounds photoreceptors R1-R6 (PubMed:18931318). In Malpighian tubules, involved in the transport of cGMP, guanine, xanthine, riboflavin, kynurenine and tryptophan (PubMed:117796, PubMed:18310115, PubMed:6788034, PubMed:812484). Probably in association with br/brown, involved in aging-induced intestinal stem cell proliferation in the midgut by regulating tetrahydrofolate transport (PubMed:33820991). Probably in association with st/scarlet, plays a role in zinc storage granule biogenesis in Malpighian tubule principal epithelial cells (PubMed:29367274)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9V3A2;Q9XY33", "ec_number_list": [ { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "7.6.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.6", "type": "external" } ], "go_molecular_function": "GO:0015196 L-tryptophan transmembrane transporter activity;GO:0005524 ATP binding;GO:0022857 transmembrane transporter activity;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0031410 cytoplasmic vesicle;GO:0098793 presynapse;GO:0048770 pigment granule", "go_biological_process": "GO:0008049 male courtship behavior;GO:0007613 memory;GO:0055085 transmembrane transport;GO:0015827 tryptophan transport;GO:0032218 riboflavin transport", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P10090-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10333-1", "uniprot_id": [ { "id": "MS2A_DROME", "url": "https://www.uniprot.org/uniprot/P10333", "type": "external" } ], "mass": 29619.0, "length": 264, "protein_name": "Accessory gland-specific peptide 26Aa", "gene_name": "Acp26Aa", "organism": "Fruit fly", "refseq_name": "accessory gland protein 26Aa", "refseq_ac": [ { "id": "NP_476644", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476644", "type": "external" } ], "gene_names_uniprotkb": "Acp26Aa; CG8982; Mst26Aa; msp355a; mst355a; ovulin", "gene_names_refseq": "Acp26Aab; Acp26Aa; Acp26A; Acp26a; Acp; CG8982; Dmel\\CG8982; Mst26Aa; Mst26A; Ovulin; msP355a; mst 355a; mst355a; ovulin", "protein_names_uniprotkb": "Accessory gland-specific peptide 26Aa; Male accessory gland secretory protein 355A", "protein_names_refseq": "Acp26Aa-PA; CG8982-PA; accessory gland peptide 26Aa; accessory gland protein 26Aa; accessory gland-specific peptide 26Aa; accessory protein 26A; ovulin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8982)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10612039;10662669;10731132;12537572;1361475;14761057;15640356;17130459;20138215;2257979;24101486;24514904;3142802;7479736;7556947;9718731;9799260", "class_list": "", "function": "Male seminal peptide which is able to enhance ovulation in female Drosophila., [UniProtKB, PubMed]; Male seminal protein which enhances ovulation in female Drosophila by stimulating the release of oocytes by the ovary following mating (PubMed:10662669, PubMed:15640356, PubMed:24101486, PubMed:7479736). Acts by increasing octopamine (OA) neuronal signaling in the female genital tract leading to the postmating relaxation of the oviduct muscles (PubMed:24101486). This activation of the OA signaling pathway is likely to indirectly contribute to the mating-dependent increase in the number of OA synaptic sites in the female reproductive tract (PubMed:24101486)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O76297;O76298;O76299;Q29QG7;Q6VBG2;Q6VBG3;Q6VBG4;Q6VBG7;Q6VBG8;Q6VBG9;Q6VBH0;Q6VBH1;Q6VBH5;Q6VBH7;Q6VBH8;Q6VBH9;Q95NY9;Q95PE8;Q9TVI6;Q9TVV6;Q9TVX0;Q9TW14;Q9TW58;Q9TW61;Q9TW81;Q9UB44;Q9UB45;Q9UB46;Q9UB47;Q9UB48;Q9UB49;Q9UB50;Q9UB51;Q9UB52;Q9UB53;Q9UB54;Q9UB55;Q9UB56;Q9UB57;Q9UB58;Q9UB59;Q9UB60;Q9UB61;Q9UB62;Q9UB63;Q9UB64;Q9UB65;Q9UB66;Q9UB67;Q9UB68;Q9UB69;Q9UB70;Q9UB71;Q9UB72;Q9UB73;Q9UB74;Q9UB75;Q9UB76;Q9UB77;Q9VML6", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0060279 positive regulation of ovulation;GO:0007320 insemination;GO:0007618 mating;GO:0046692 sperm competition;GO:2000130 positive regulation of octopamine signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P10333-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10334-1", "uniprot_id": [ { "id": "MS2B_DROME", "url": "https://www.uniprot.org/uniprot/P10334", "type": "external" } ], "mass": 10162.0, "length": 90, "protein_name": "Accessory gland-specific peptide 26Ab", "gene_name": "Acp26Ab", "organism": "Fruit fly", "refseq_name": "accessory gland protein 26Ab, isoform C", "refseq_ac": [ { "id": "NP_001285646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285646", "type": "external" } ], "gene_names_uniprotkb": "Acp26Ab; Acp26Aab; Acp26A; Acp26a; Acp; CG9024; Dmel\\CG9024; Dmel_CG9024; Mst26Ab; Mst26A; acp26Ab; msP355b; msp355b; mst 355b; mst355b", "gene_names_refseq": "Acp26Aab; Acp26Ab; Acp26A; Acp26a; Acp; CG9024; Dmel\\CG9024; Mst26Ab; Mst26A; acp26Ab; msP355b; mst 355b; mst355b", "protein_names_uniprotkb": "Accessory gland-specific peptide 26Ab; Male accessory gland secretory protein 355B", "protein_names_refseq": "Acp26Ab-PC; CG9024-PC; accessory gland protein 26Ab, isoform C; accessory gland-specific peptide 26Ab; accessory protein 26A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9024)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;1361475;16110336;17569856;17569867;2257979;25589440;26109356;26109357;3142802;9718731;9799260", "class_list": "", "function": "This protein is transferred from male to female during mating and may affect egglaying and behavior after mating., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JQ48;A4V091;O76300;O76302;O77456;O97184;O97185;O97456;O97460;Q4V3V8;Q95NY1;Q95NY2;Q95NY3;Q9V432", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0007320 insemination;GO:0007618 mating;GO:0007617 mating behavior", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P10334-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11146-1", "uniprot_id": [ { "id": "HSP7B_DROME", "url": "https://www.uniprot.org/uniprot/P11146", "type": "external" } ], "mass": 69722.0, "length": 633, "protein_name": "Heat shock 70 kDa protein cognate 2", "gene_name": "Hsc70-2", "organism": "Fruit fly", "refseq_name": "heat shock protein 70 cognate 2", "refseq_ac": [ { "id": "NP_524339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524339", "type": "external" } ], "gene_names_uniprotkb": "Hsc70-2; CG7756; Hsc2", "gene_names_refseq": "CG7756; Dmel\\CG7756; HSC-70; HSC2; HSC70-2; HSC70; HSP70cA8; HSP7B_DROME; Hsc-2; Hsc2; Hsc70-2; Hsc70.2; Hsc70; dhsc70; hsc2; hsc70; hsp70", "protein_names_uniprotkb": "Heat shock 70 kDa protein cognate 2; Heat shock 70 kDa protein 87D", "protein_names_refseq": "70 kDa heat shock protein, cytosolic A 8; CG7756-PA; Hs protein cognate 2; Hsc70-2-PA; Hsp cognate 2; heat shock protein 70 cognate 2; heat shock protein cognate 2; heat shock protein cognate-2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7756)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;6311649", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U0V1;Q9VFZ5", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006950 response to stress;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P11146-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11147-1", "uniprot_id": [ { "id": "HSP7D_DROME", "url": "https://www.uniprot.org/uniprot/P11147", "type": "external" } ], "mass": 71131.0, "length": 651, "protein_name": "Heat shock 70 kDa protein cognate 4", "gene_name": "Hsc70-4", "organism": "Fruit fly", "refseq_name": "heat shock protein 70 cognate 4, isoform G", "refseq_ac": [ { "id": "NP_001262586", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262586", "type": "external" } ], "gene_names_uniprotkb": "Hsc70-4; CG4264; Hsc4", "gene_names_refseq": "BAP74; Bap74; C7LA75; CG4264; Dmel\\CG4264; E(csp)1545; E(nd)195; HSC-70; HSC4; HSC70-4; HSC70; HSP70cB2; HSP70; Hsc-4; Hsc-70-4; Hsc4p; Hsc4; Hsc70-4; Hsc70.4; Hsc70; Hsp-c4; Hsp70; Q3KN45_DROME; anon-WO0118547.237; bs17d06.y1; chr3R:11070155..11070315; dHSP70; dHsp70; dhsc70; hsc4; hsc70-4; hsc70; hsp70; i190; l(3)03550; l(3)L3929; l(3)j7A4; mtHsp 70; scd", "protein_names_uniprotkb": "Heat shock 70 kDa protein cognate 4; Heat shock 70 kDa protein 88E", "protein_names_refseq": "70 kDa heat shock protein, cytosolic B 2; Bap74; CG4264-PG; Hsc70-4-PG; heat shock 70 kDa protein cognate 4; heat shock 70-kDa protein cognate 4; heat shock cognate 4; heat shock cognate 70; heat shock cognate protein 4; heat shock cognate protein 70-4; heat shock protein 70 cognate 4, isoform G; heat shock protein 70; heat shock protein cognate 4; heat-shock protein 70; hsp cognate 4; scattered", "tax_id": 7227, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); lymphoma (Disease Ontology:DOID:0060058); graft-versus-host disease (Disease Ontology:DOID:0081267); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); acute kidney failure (Disease Ontology:DOID:3021); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); cervical cancer (Disease Ontology:DOID:4362); macular degeneration (Disease Ontology:DOID:4448); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG4264); (R-DME-3371453); (R-DME-3371497); (R-DME-3371571); (R-DME-450408); (R-DME-6798695); (R-DME-9841251)", "pathway_count": 7, "publication_count": 10, "publication_id_list": "10731132;12537569;12537572;15952742;17893096;2111451;36302967;6311649;8500545;8514184", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 15, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3KN45;Q8SXQ4;Q9VFB0", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0051087 protein-folding chaperone binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0070922 RISC complex assembly;GO:0097753 membrane bending;GO:0061738 late endosomal microautophagy;GO:0007399 nervous system development;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P11147-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.1100000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11584-1", "uniprot_id": [ { "id": "ITBX_DROME", "url": "https://www.uniprot.org/uniprot/P11584", "type": "external" } ], "mass": 92656.0, "length": 846, "protein_name": "Integrin beta-PS", "gene_name": "mys", "organism": "Fruit fly", "refseq_name": "myospheroid, isoform C", "refseq_ac": [ { "id": "NP_001284998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284998", "type": "external" } ], "gene_names_uniprotkb": "mys; BetaPS-Int; BetaPS; CG1560; CT40473; Dmel\\CG1560; Dmel_CG1560; EM28; Integrin beta; ItgbPS; MAb6G11; Mys; PS integrin; PS[[beta]]; PSbeta; PS; bPS; b[[PS]]; beta integrin; beta-Integrin; beta-Int; beta-PS-integrin; beta-PS; beta-integrin; beta-int; beta1; betaInt; betaPS Int; betaPS integrin; betaPS-Integrin; betaPS-integrin; betaPS1; betaPS; beta[[PS]]-integrin; beta[[PS]]; beta[[P]]S; beta[[mys]]; betamys; integrin beta[[PS]]; l(1)7Db; l(1)7Dn; l(1)93p; l(1)968; l(1)DA551; l(1)EM28; l(1)G0233; l(1)G0281; l(1)mys; nj42; olfC", "gene_names_refseq": "BetaPS-Int; BetaPS; CG1560; CT40473; Dmel\\CG1560; EM28; Integrin beta; ItgbPS; MAb6G11; Mys; PS integrin; PS[[beta]]; PSbeta; PS; bPS; b[[PS]]; beta integrin; beta-Integrin; beta-Int; beta-PS-integrin; beta-PS; beta-integrin; beta-int; beta1; betaInt; betaPS Int; betaPS integrin; betaPS-Integrin; betaPS-integrin; betaPS1; betaPS; beta[[PS]]-integrin; beta[[PS]]; beta[[P]]S; beta[[mys]]; betamys; integrin beta[[PS]]; l(1)7Db; l(1)7Dn; l(1)93p; l(1)968; l(1)DA551; l(1)EM28; l(1)G0233; l(1)G0281; l(1)mys; mys; nj42; olfC", "protein_names_uniprotkb": "Integrin beta-PS; Position-specific antigen beta subunit; Protein myospheroid; Protein olfactory C", "protein_names_refseq": "CG1560-PC; Integrin-betaPS; Myospheroid/betaPS integrin; PS integrin beta subunit; PS-beta-integrin; PSbeta-integrin; beta PS integrin; beta integrin; beta-PS integrin; beta-PS-Integrin; beta-PS1 integrin; beta-integrin; beta1 integrin; beta1-integrin; betaIntegrin; betaPS integrin subunit; betaPS integrin; betaPS-Integrin; betaPS.*integrin; betaPS; beta[[PS]] integrin subunit; beta[[PS]] integrin; beta[[PS]]-integrin; beta[[mys]]-integrin; integrin PSbeta; integrin beta1; integrin betaPS subunit; integrin beta[[PS]] subunit; integrin betaps; integrinbeta; lethal myospheroid; lethal(1)93 pupal; lethal(1)myospheroid; myo-spheroid; myospheriod; myospheroid, isoform C; mys-PC; non-jumper-42; olfactory C; olfactory-C", "tax_id": 7227, "disease": "non-arteritic anterior ischemic optic neuropathy (Disease Ontology:DOID:0050864); myelodysplastic syndrome (Disease Ontology:DOID:0050908); stroke (Disease Ontology:DOID:0051061); platelet-type bleeding disorder 16 (Disease Ontology:DOID:0060691); colorectal carcinoma (Disease Ontology:DOID:0080199); amelogenesis imperfecta type 1H (Disease Ontology:DOID:0110064); leukocyte adhesion deficiency 1 (Disease Ontology:DOID:0110910); Hirschsprung's disease (Disease Ontology:DOID:10487); hydrocephalus (Disease Ontology:DOID:10908); nephritis (Disease Ontology:DOID:10952); Hantavirus hemorrhagic fever with renal syndrome (Disease Ontology:DOID:11266); Vogt-Koyanagi-Harada disease (Disease Ontology:DOID:12297); Graves' disease (Disease Ontology:DOID:12361); thrombocytopenia (Disease Ontology:DOID:1588); cancer (Disease Ontology:DOID:162); blood platelet disease (Disease Ontology:DOID:2218); Glanzmann's thrombasthenia (Disease Ontology:DOID:2219); transient cerebral ischemia (Disease Ontology:DOID:224); asthma (Disease Ontology:DOID:2841); glomerulonephritis (Disease Ontology:DOID:2921); Epstein-Barr virus infectious disease (Disease Ontology:DOID:2938); IgA glomerulonephritis (Disease Ontology:DOID:2986); lung non-small cell carcinoma (Disease Ontology:DOID:3908); coronary restenosis (Disease Ontology:DOID:4247); allergic rhinitis (Disease Ontology:DOID:4481); liver cirrhosis (Disease Ontology:DOID:5082); lung small cell carcinoma (Disease Ontology:DOID:5409); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); leukocyte adhesion deficiency (Disease Ontology:DOID:6612); end stage renal disease (Disease Ontology:DOID:783); myocarditis (Disease Ontology:DOID:820); bacterial pneumonia (Disease Ontology:DOID:874); psoriasis (Disease Ontology:DOID:8893); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); diabetic retinopathy (Disease Ontology:DOID:8947); acute myeloid leukemia (Disease Ontology:DOID:9119); pulmonary emphysema (Disease Ontology:DOID:9675)", "pathway": " (dme:Dmel_CG1560); (R-DME-114608); (R-DME-1236973); (R-DME-198933); (R-DME-202733); (R-DME-210991); (R-DME-2129379); (R-DME-216083); (R-DME-2173789); (R-DME-3000170); (R-DME-354192); (R-DME-445144); (R-DME-445355); (R-DME-446107); (R-DME-446343); (R-DME-6798695); (R-DME-9013149); (R-DME-9013423); (R-DME-9860927)", "pathway_count": 19, "publication_count": 25, "publication_id_list": "10731132;10821184;12537568;12537569;12537572;12537573;12537574;15469969;16110336;17569856;17569867;17893096;19035354;19349973;25589440;26109356;26109357;27191715;3128792;33925313;38283991;7924982;7972082;8119134;9660786", "class_list": "", "function": "Integrin alpha-PS1/beta-PS is a receptor for laminin (PubMed:7972082). Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m (PubMed:7924982, PubMed:7972082, PubMed:9660786). Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle (PubMed:15469969). Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium (PubMed:15469969). The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/talin and Itgbn does not (PubMed:15469969). Required for rhea/talin correct cellular localization in the midgut (PubMed:15469969). Required for many embryonic (dorsal closure and somatic muscle attachments) and postembryonic developmental processes (attachment between cell layers of imaginal disks, organization of ommatidial arrays and flight muscle development) (PubMed:10821184, PubMed:7924982, PubMed:7972082, PubMed:8119134). Involved in the function and/or development of the olfactory system (PubMed:10821184). In the testes, essential for shv-dependent maintenance of somatic hub cells and their localization to the apical tip (PubMed:27191715). Plays a role in timely border cell migration during oogenesis (PubMed:19035354)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 38, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q8MYX9;Q9W3L2", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005178 integrin binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0030425 dendrite;GO:0031252 cell leading edge", "go_biological_process": "GO:0021551 central nervous system morphogenesis;GO:0007015 actin filament organization;GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0030336 negative regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 3.2, "record_id": "P11584-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11995-1", "uniprot_id": [ { "id": "LSP1A_DROME", "url": "https://www.uniprot.org/uniprot/P11995", "type": "external" } ], "mass": 98868.0, "length": 816, "protein_name": "Larval serum protein 1 alpha chain", "gene_name": "Lsp1alpha", "organism": "Fruit fly", "refseq_name": "larval serum protein 1 alpha", "refseq_ac": [ { "id": "NP_511138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_511138", "type": "external" } ], "gene_names_uniprotkb": "Lsp1alpha; CG2559; LSP1-a", "gene_names_refseq": "CG2559; DmeLSP1a; Dmel\\CG2559; LSP 1; LSP-1 alpha; LSP-1alpha; LSP-1; LSP1-alpha; LSP1ALPHA; LSP1alpha; LSP1; Lsp-1alpha; Lsp1-alpha; Lsp1alpha; Lsp1; Lsp", "protein_names_uniprotkb": "Larval serum protein 1 alpha chain; Hexamerin-1-alpha", "protein_names_refseq": "CG2559-PA; Lsp1alpha-PA; larval serum protein 1 alpha; larval serum protein one alpha; larval serum protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2559)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;16453657;3097321", "class_list": "", "function": "Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VYM4", "ec_number_list": [], "go_molecular_function": "GO:0045735 nutrient reservoir activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005616 larval serum protein complex", "go_biological_process": "GO:0097009 energy homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P11995-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11997-1", "uniprot_id": [ { "id": "LSP1G_DROME", "url": "https://www.uniprot.org/uniprot/P11997", "type": "external" } ], "mass": 93408.0, "length": 772, "protein_name": "Larval serum protein 1 gamma chain", "gene_name": "Lsp1gamma", "organism": "Fruit fly", "refseq_name": "larval serum protein 1 gamma", "refseq_ac": [ { "id": "NP_523868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523868", "type": "external" } ], "gene_names_uniprotkb": "Lsp1gamma; CG6821; Lsp1-g", "gene_names_refseq": "CG6821; DmeLSP1g; Dmel\\CG6821; LSP 1; LSP-1 gamma; LSP-1gamma; LSP-1; LSP1; Lsp-1gamma; Lsp1 gamma; Lsp1-gamma; Lsp1[gamma]; Lsp1gama; Lsp1gamma; Lsp1; lsp1g", "protein_names_uniprotkb": "Larval serum protein 1 gamma chain; Hexamerin-1-gamma", "protein_names_refseq": "CG6821-PA; Lsp1gamma-PA; larval serum protein 1 gamma; larval serum protein 1[gamma]; larval serum protein 1gamma", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6821)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;3097321;33925313;9402735", "class_list": "", "function": "Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O16162;Q9W0V6", "ec_number_list": [], "go_molecular_function": "GO:0045735 nutrient reservoir activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005616 larval serum protein complex", "go_biological_process": "GO:0097009 energy homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P11997-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12080-1", "uniprot_id": [ { "id": "ITA2_DROME", "url": "https://www.uniprot.org/uniprot/P12080", "type": "external" } ], "mass": 154322.0, "length": 1396, "protein_name": "Integrin alpha-PS2", "gene_name": "if", "organism": "Fruit fly", "refseq_name": "inflated, isoform D", "refseq_ac": [ { "id": "NP_001162777", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162777", "type": "external" } ], "gene_names_uniprotkb": "if; CG9623", "gene_names_refseq": "CG9623; CT27194; Dmel\\CG9623; IF; If; Integrin alpha PS2; ItgaPS2; PS 2; PS2(c); PS2(m8)alpha; PS2(m8); PS2alpha; PS2; PSalpha2; aPS2; alpha-PS2; alpha2Int; alphaPS2 integrin; alphaPS2C; alphaPS2m8; alphaPS2; alpha[[PS2(ms8)]]; alpha[[PS2]]; if; inf; in", "protein_names_uniprotkb": "Integrin alpha-PS2; Position-specific antigen subunit alpha-2; Protein inflated", "protein_names_refseq": "CG9623-PD; PS II alpha; alpha integrin; alpha-PS2-integrin; alpha-integrin; alpha2 integrin; alphaPS2 integrin; alphaPS2-integrin; alpha[[PS2]] integrin; if-PD; inflated, isoform D; integrin PSI alpha subunit; integrin alpha PS2; integrin alphaPS2 subunit; position-specific antigen 2", "tax_id": 7227, "disease": "stroke (Disease Ontology:DOID:0051061); autism spectrum disorder (Disease Ontology:DOID:0060041); von Willebrand's disease 1 (Disease Ontology:DOID:0060573); congenital chylothorax (Disease Ontology:DOID:0060646); platelet-type bleeding disorder 16 (Disease Ontology:DOID:0060691); intellectual disability (Disease Ontology:DOID:1059); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); nephritis (Disease Ontology:DOID:10952); corneal neovascularization (Disease Ontology:DOID:11382); renal agenesis (Disease Ontology:DOID:14766); thrombocytopenia (Disease Ontology:DOID:1588); pancreatic cancer (Disease Ontology:DOID:1793); Glanzmann's thrombasthenia (Disease Ontology:DOID:2219); ovarian cancer (Disease Ontology:DOID:2394); severe acute respiratory syndrome (Disease Ontology:DOID:2945); ischemia (Disease Ontology:DOID:326); cerebral infarction (Disease Ontology:DOID:3526); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); coronary stenosis (Disease Ontology:DOID:4248); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); mesangial proliferative glomerulonephritis (Disease Ontology:DOID:4783); schizophrenia (Disease Ontology:DOID:5419); pneumonia (Disease Ontology:DOID:552); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); diabetic retinopathy (Disease Ontology:DOID:8947); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (dme:Dmel_CG9623); (R-DME-114608); (R-DME-1236973); (R-DME-2129379); (R-DME-216083); (R-DME-2173789); (R-DME-3000170); (R-DME-354192); (R-DME-445144); (R-DME-6798695); (R-DME-9860927)", "pathway_count": 11, "publication_count": 15, "publication_id_list": "10731132;10821184;12537569;12537572;15469969;19035354;2507168;28604694;2961459;33925313;40245499;7924982;7972082;8240969;9660786", "class_list": "", "function": "Alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Involved in the function and/or development of the olfactory system., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 14, "predicted_n_glycosites": 12, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 6, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 6, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 6, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 30, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "E1JJN2;Q8IR07;Q8MSG3;Q9VXB6", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0050840 extracellular matrix binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0016324 apical plasma membrane;GO:0042383 sarcolemma", "go_biological_process": "GO:0021551 central nervous system morphogenesis;GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0033627 cell adhesion mediated by integrin;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 2.3, "record_id": "P12080-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0100000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12646-1", "uniprot_id": [ { "id": "G6PD_DROME", "url": "https://www.uniprot.org/uniprot/P12646", "type": "external" } ], "mass": 60415.0, "length": 524, "protein_name": "Glucose-6-phosphate 1-dehydrogenase", "gene_name": "G6pd", "organism": "Fruit fly", "refseq_name": "zwischenferment, isoform C", "refseq_ac": [ { "id": "NP_001285456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285456", "type": "external" } ], "gene_names_uniprotkb": "G6pd; CG12529; Zw", "gene_names_refseq": "CG12529; Dmel\\CG12529; G-6-PD; G-6-pdh; G-6PD; G-6pd; G6-PD; G6-pd; G6PDH; G6PD; G6pdh; G6pd; Zw; g6pd; zw", "protein_names_uniprotkb": "Glucose-6-phosphate 1-dehydrogenase; 1.1.1.49; Protein zwischenferment", "protein_names_refseq": "CG12529-PC; Glucose-6-phosphate DH; Zw-PC; glucose 6-phosphate dehydrogenase; glucose-6-phosphate 1dehydrogenase; glucose-6-phosphate dehydrogenase; zwischenferment, isoform C; zwischenferment; zwishenferment", "tax_id": 7227, "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); congenital nonspherocytic hemolytic anemia 1 (Disease Ontology:DOID:0051003); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); malaria (Disease Ontology:DOID:12365); hepatic encephalopathy (Disease Ontology:DOID:13413); cholestasis (Disease Ontology:DOID:13580); favism (Disease Ontology:DOID:13628); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); renovascular hypertension (Disease Ontology:DOID:1591); transient cerebral ischemia (Disease Ontology:DOID:224); anemia (Disease Ontology:DOID:2355); neonatal jaundice (Disease Ontology:DOID:2383); congenital nonspherocytic hemolytic anemia (Disease Ontology:DOID:2861); kidney disease (Disease Ontology:DOID:557); hemolytic anemia (Disease Ontology:DOID:583); myocardial infarction (Disease Ontology:DOID:5844); cerebrovascular disease (Disease Ontology:DOID:6713); hepatocellular carcinoma (Disease Ontology:DOID:684); cataract (Disease Ontology:DOID:83); hyperhomocysteinemia (Disease Ontology:DOID:9279); phenylketonuria (Disease Ontology:DOID:9281); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG12529); (R-DME-5628897); (R-DME-71336)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;18327897;2838391;35780586;8913747", "class_list": "", "function": "Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 25, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7FNK0;Q27574;Q27872;Q27879;Q27881;Q9VWE2;Q9VWE3;X2JEF0", "ec_number_list": [ { "id": "1.1.1.49", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.49", "type": "external" } ], "go_molecular_function": "GO:0004345 glucose-6-phosphate dehydrogenase activity;GO:0050661 NADP binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0009051 pentose-phosphate shunt, oxidative branch;GO:0006006 glucose metabolic process;GO:0051156 glucose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P12646-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13095-1", "uniprot_id": [ { "id": "ESM4_DROME", "url": "https://www.uniprot.org/uniprot/P13095", "type": "external" } ], "mass": 17250.0, "length": 152, "protein_name": "Enhancer of split m4 protein", "gene_name": "E(spl)m4-BFM", "organism": "Fruit fly", "refseq_name": "enhancer of split m4, bearded family member", "refseq_ac": [ { "id": "NP_524510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524510", "type": "external" } ], "gene_names_uniprotkb": "E(spl)m4-BFM; CG6099; m4", "gene_names_refseq": "CG6099; DmelCG6099; Dmel\\CG6099; E(spl) m4; E(spl)m4-BFM; E(spl)m4; HLHm4; m4", "protein_names_uniprotkb": "Enhancer of split m4 protein; E(spl)m4", "protein_names_refseq": "CG6099-PA; E(spl) region transcript 4; E(spl) region transcript m4; E(spl)m4-BFM-PA; enhancer of split m4, bearded family member; enhancer of split m4", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6099)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;15537803;16356268;2540957", "class_list": "", "function": "Part of the Notch signaling pathway., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q56L08;Q56L11;Q56L12;Q56L19;Q56L29;Q56L35;Q56L44;Q56L45;Q56L64;Q56L67;Q56L68;Q56L69;Q56L92;Q5S478;Q5S4B4;Q5S4J8;Q9VBI9", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "", "go_biological_process": "GO:0001708 cell fate specification;GO:0007219 Notch signaling pathway;GO:0007399 nervous system development;GO:0045746 negative regulation of Notch signaling pathway;GO:0007423 sensory organ development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P13095-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13238-1", "uniprot_id": [ { "id": "VTU2_DROME", "url": "https://www.uniprot.org/uniprot/P13238", "type": "external" } ], "mass": 16771.0, "length": 168, "protein_name": "Vitelline membrane protein Vm26Ab", "gene_name": "Vm26Ab", "organism": "Fruit fly", "refseq_name": "vitelline membrane 26Ab, isoform B", "refseq_ac": [ { "id": "NP_001285648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285648", "type": "external" } ], "gene_names_uniprotkb": "Vm26Ab; CG9046; DIM 29; Dm sV23; Dmel\\CG9046; Dmel_CG9046; Sv23; TU-4; VM26A.2; VM26AB; Vm26A; fs(2)QJ42; sV23; sV26; sv23", "gene_names_refseq": "CG9046; DIM 29; Dm sV23; Dmel\\CG9046; Sv23; TU-4; VM26A.2; VM26AB; Vm26Ab; Vm26A; fs(2)QJ42; sV23; sV26; sv23", "protein_names_uniprotkb": "Vitelline membrane protein Vm26Ab; Protein SV23; Protein TU-4", "protein_names_refseq": "CG9046-PB; Vm26Ab-PB; vitelline membrane 26Ab, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9046)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;15136154;16110336;17244601;17569856;17569867;18514182;20832396;25589440;26109356;26109357;3132408", "class_list": "", "function": "Major early eggshell protein secreted by follicle cells into the perivitelline space and incorporated into the vitelline membrane (PubMed:3132408). Involved in vitelline membrane biogenesis; forms a cross-linked network with other vitelline membrane components (PubMed:15136154, PubMed:18514182, PubMed:20832396)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UM08;Q9VMK6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0060388 vitelline envelope", "go_biological_process": "GO:0009617 response to bacterium;GO:0007343 egg activation;GO:0007304 chorion-containing eggshell formation;GO:0007305 vitelline membrane formation involved in chorion-containing eggshell formation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P13238-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13468-1", "uniprot_id": [ { "id": "K10_DROME", "url": "https://www.uniprot.org/uniprot/P13468", "type": "external" } ], "mass": 51267.0, "length": 463, "protein_name": "DNA-binding protein K10", "gene_name": "fs(1)K10", "organism": "Fruit fly", "refseq_name": "female sterile (1) K10", "refseq_ac": [ { "id": "NP_477491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477491", "type": "external" } ], "gene_names_uniprotkb": "fs(1)K10; CG3218", "gene_names_refseq": "CG3218; Dmel\\CG3218; EG:30B8.5; K-10; K10; f(s)K10; fs(1)K10; fs(1)M9; fs(1)k10; k10", "protein_names_uniprotkb": "DNA-binding protein K10; Female sterile protein K10", "protein_names_refseq": "CG3218-PA; female sterile (1) K10; fs(1)K10-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3218)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10197986;10731132;10731137;12537569;12537572;12553295", "class_list": "", "function": "May be involved in localization of sqd to the oocyte during oogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O46075;Q9W505", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0017148 negative regulation of translation;GO:0008104 intracellular protein localization;GO:0009953 dorsal/ventral pattern formation;GO:0048477 oogenesis;GO:0008298 intracellular mRNA localization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P13468-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14318-1", "uniprot_id": [ { "id": "MP20_DROME", "url": "https://www.uniprot.org/uniprot/P14318", "type": "external" } ], "mass": 20190.0, "length": 184, "protein_name": "Muscle-specific protein 20", "gene_name": "Mp20", "organism": "Fruit fly", "refseq_name": "muscle protein 20, isoform C", "refseq_ac": [ { "id": "NP_001014522", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014522", "type": "external" } ], "gene_names_uniprotkb": "Mp20; CG4696; Tpn", "gene_names_refseq": "CG4696; DMMP20; Dmel\\CG4696; Dmmp20; MP20; Mp20; Tpn; mp20", "protein_names_uniprotkb": "Muscle-specific protein 20", "protein_names_refseq": "CG4696-PC; Mp20-PC; muscle protein 20 kd; muscle protein 20, isoform C; muscle protein 20; myophilin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4696); (R-DME-114608); (R-DME-6798695)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;2537318", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZF7;Q1WWC7;Q9V6M7", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0007520 myoblast fusion;GO:1901739 regulation of myoblast fusion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P14318-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14773-1", "uniprot_id": [ { "id": "HMDH_DROME", "url": "https://www.uniprot.org/uniprot/P14773", "type": "external" } ], "mass": 98317.0, "length": 920, "protein_name": "3-hydroxy-3-methylglutaryl-coenzyme A reductase", "gene_name": "Hmgcr", "organism": "Fruit fly", "refseq_name": "HMG coenzyme A reductase", "refseq_ac": [ { "id": "NP_732900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_732900", "type": "external" } ], "gene_names_uniprotkb": "Hmgcr; CG10367; HmG-CoAR", "gene_names_refseq": "BcDNA:LD15354; CG10367; Clb; DmHMG-CoAr; Dmel\\CG10367; HMGCR_Dm; HMGCR; HMGCoARr; HMGCoAR; HMGCoAr; HMGR; HmG-CoAR; Hmgcr; Hmg; bro1; bs32f05.y1; clb; hmgcr; hmgc; hmgrc; l(3)01152; l(3)04684", "protein_names_uniprotkb": "3-hydroxy-3-methylglutaryl-coenzyme A reductase; 1.1.1.34; HMG-CoA reductase", "protein_names_refseq": "3-Hydroxy-3-Methylglutaryl CoA reductase; 3-hydroxy-3-methylglutaryl coenzyme A reductase; CG10367-PA; HMG coenzyme A reductase; HMG-CoA reductase class I; HMGCo-A reductase; HMGCoA reductase; Hmg-CoA-reductase; Hmgcr-PA; columbus; lethal (3) 04684", "tax_id": 7227, "disease": "stroke (Disease Ontology:DOID:0051061); autosomal recessive limb-girdle muscular dystrophy type 28 (Disease Ontology:DOID:0061130); metabolic dysfunction and alcohol associated liver disease (Disease Ontology:DOID:0070508); muscular disease (Disease Ontology:DOID:0080000); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); premature menopause (Disease Ontology:DOID:10787); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); morbid obesity (Disease Ontology:DOID:11981); dementia (Disease Ontology:DOID:1307); Parkinson's disease (Disease Ontology:DOID:14330); drug-induced hepatitis (Disease Ontology:DOID:2044); asthma (Disease Ontology:DOID:2841); coronary artery disease (Disease Ontology:DOID:3393); myopathy (Disease Ontology:DOID:423); pulmonary hypertension (Disease Ontology:DOID:6432); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); intermediate coronary syndrome (Disease Ontology:DOID:8805); Wilson disease (Disease Ontology:DOID:893); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dme:Dmel_CG10367); (R-DME-9969896)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537572;3136321;9853754", "class_list": "", "function": "Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation. Provides spatial information during embryogenesis to guide migrating primordial germ cells (the pole cells) from the ectoderm to the mesoderm. Also required for association of the pole cells with the gonadal mesoderm., [UniProtKB, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 22, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "A4V3A8;Q9VCI8", "ec_number_list": [ { "id": "1.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.34", "type": "external" } ], "go_molecular_function": "GO:0050661 NADP binding;GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity", "go_cellular_component": "GO:0005778 peroxisomal membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0007626 locomotory behavior;GO:0016126 sterol biosynthetic process;GO:0015936 coenzyme A metabolic process;GO:0008354 germ cell migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P14773-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14956-1", "uniprot_id": [ { "id": "CECB_DROME", "url": "https://www.uniprot.org/uniprot/P14956", "type": "external" } ], "mass": 6778.0, "length": 63, "protein_name": "Cecropin-B", "gene_name": "CecB", "organism": "Fruit fly", "refseq_name": "cecropin B", "refseq_ac": [ { "id": "NP_524590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524590", "type": "external" } ], "gene_names_uniprotkb": "CecB; CG1878", "gene_names_refseq": "CECB; CG1878; Cec B; CecB; CecropinB; Cec; Dmel\\CG1878; cecB; cec; cedcB; crpB", "protein_names_uniprotkb": "Cecropin-B", "protein_names_refseq": "CG1878-PA; CecB-PA; Cecropin-B precursor; Cecropin-B; cecropin B; cecropins; cecropin; cercropin B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1878)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;12537572;2104802;2390977;9335607;9553148;9725836", "class_list": "", "function": "Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O16826;O16827;O16828;O18647;O61274;Q9V425", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P14956-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15215-1", "uniprot_id": [ { "id": "LAMC1_DROME", "url": "https://www.uniprot.org/uniprot/P15215", "type": "external" } ], "mass": 182339.0, "length": 1639, "protein_name": "Laminin subunit gamma-1", "gene_name": "LanB2", "organism": "Fruit fly", "refseq_name": "laminin B2, isoform B", "refseq_ac": [ { "id": "NP_001287009", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287009", "type": "external" } ], "gene_names_uniprotkb": "LanB2; CG3322; CT11145; DROLAMB2A; Dmel\\CG3322; Dmel_CG3322; LAMB2A; LAMC1; LAMG1; LMG1; Lam-B2; Lmgamma1; anon-EST:fe2H3; gamma1; gamma; knod; l(3)67BDb; lamB2; laminin; lanB2", "gene_names_refseq": "CG3322; CT11145; DROLAMB2A; Dmel\\CG3322; LAMB2A; LM-B2/gamma; LMG1; Lam-B2; LanB2; Lmgamma1; anon-EST:fe2H3; gamma1; knod; l(3)67BDb; lamB2; laminin; lanB2", "protein_names_uniprotkb": "Laminin subunit gamma-1; Laminin B2 chain", "protein_names_refseq": "CG3322-PB; LamininB2; LanB2-PB; anon-fast-evolving-2H3; knodel; laminin B2 subunit; laminin B2, isoform B; laminin gamma 1; laminin gamma-chain; laminin gamma1; laminin gamma2; lamininB; lethal (3) 67BDb", "tax_id": 7227, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); junctional epidermolysis bullosa Herlitz type (Disease Ontology:DOID:0060737); junctional epidermolysis bullosa non-Herlitz type (Disease Ontology:DOID:0060738); junctional epidermolysis bullosa (Disease Ontology:DOID:3209); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung small cell carcinoma (Disease Ontology:DOID:5409)", "pathway": " (dme:Dmel_CG3322)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;1840513;25589440;26109356;26109357;2808533;2912972;3405777", "class_list": "", "function": "Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components., [UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "Q24373;Q5BI30;Q9VT18", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005604 basement membrane", "go_biological_process": "GO:0085029 extracellular matrix assembly;GO:0061031 endodermal digestive tract morphogenesis;GO:0033627 cell adhesion mediated by integrin;GO:0007494 midgut development;GO:0009887 animal organ morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P15215-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15348-1", "uniprot_id": [ { "id": "TOP2_DROME", "url": "https://www.uniprot.org/uniprot/P15348", "type": "external" } ], "mass": 164396.0, "length": 1447, "protein_name": "DNA topoisomerase 2", "gene_name": "Top2", "organism": "Fruit fly", "refseq_name": "topoisomerase 2, isoform B", "refseq_ac": [ { "id": "NP_001260580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260580", "type": "external" } ], "gene_names_uniprotkb": "Top2; CG10223", "gene_names_refseq": "CG10223; CHRAC; Dmel\\CG10223; TOP2; TOPO II; TOPOII; Top2; TopII; Topo II; TopoII; Topoll; dCHRAC; dTopoII; dmTopoII; suo; top2; topo 2; topo II; topoII", "protein_names_uniprotkb": "DNA topoisomerase 2; 5.6.2.2; DNA topoisomerase II", "protein_names_refseq": "CG10223-PB; DNA topoisomerase II; DNA topoisomeriase II; Top 2; Top2-PB; Topoisomerase2; solofuso; topoisomerase 2, isoform B; topoisomerase 2; topoisomerase II; type II DNA topoisomerase; type II topoisomerase", "tax_id": 7227, "disease": "ductal carcinoma in situ (Disease Ontology:DOID:0060074); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); penile benign neoplasm (Disease Ontology:DOID:11624); limited scleroderma (Disease Ontology:DOID:1577); diffuse scleroderma (Disease Ontology:DOID:1580); cancer (Disease Ontology:DOID:162); B cell deficiency (Disease Ontology:DOID:2115); nephroblastoma (Disease Ontology:DOID:2154); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (dme:Dmel_CG10223); (R-DME-4615885)", "pathway_count": 2, "publication_count": 20, "publication_id_list": "10731132;10751154;10786800;10885744;11172718;12537572;1328202;14600258;18327897;18752348;21304601;23989663;25340780;2538621;2547764;27129233;6308011;8383533;8978614;9545289", "class_list": "", "function": "Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands (PubMed:10786800, PubMed:1328202, PubMed:2547764, PubMed:6308011, PubMed:8383533, PubMed:8978614). Topoisomerase II makes double-strand breaks (PubMed:10786800, PubMed:1328202, PubMed:2547764, PubMed:6308011, PubMed:8383533, PubMed:9545289). Essential during mitosis and meiosis for proper segregation of daughter chromosomes (PubMed:10751154, PubMed:14600258, PubMed:18752348, PubMed:25340780). During meiosis, it disrupts heterochromatic connections between achiasmate and chiasmate homologs after spindle assembly so that chromosomes can separate at prometaphase I (PubMed:25340780). During mitosis, it functions in the separation of sister chromatids by establishing amphitelic kinetochore attachments in mitotic spindles (PubMed:18752348). May have a role in chromatin condensation and chromosome structure (PubMed:14600258, PubMed:18752348, PubMed:25340780). May be involved in X-chromosome dosage compensation, perhaps by modifying the topological state of compensated genes (PubMed:23989663). Regulates activity of the gypsy chromatin insulator complex by binding to mod(mdg4) and preventing its degradation (PubMed:21304601)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M9PDQ1;Q6NR40;Q9VIW2", "ec_number_list": [ { "id": "5.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003729 mRNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0051310 metaphase chromosome alignment;GO:0007060 male meiosis chromosome segregation;GO:0000278 mitotic cell cycle;GO:0007076 mitotic chromosome condensation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "P15348-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16620-1", "uniprot_id": [ { "id": "PTP69_DROME", "url": "https://www.uniprot.org/uniprot/P16620", "type": "external" } ], "mass": 167460.0, "length": 1462, "protein_name": "Tyrosine-protein phosphatase 69D", "gene_name": "Ptp69D", "organism": "Fruit fly", "refseq_name": "protein tyrosine phosphatase 69D, isoform A", "refseq_ac": [ { "id": "NP_524048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524048", "type": "external" } ], "gene_names_uniprotkb": "Ptp69D; CG10975; DPTP", "gene_names_refseq": "69D; CG10975; CT30751; DPTP69D; DPTP; Dmel\\CG10975; Dptp69D; PTP69D; PTPase; Ptp69D; Ptp69d; Ptp; R-PTP 69D; RPtp69D; dptp69D; dptp69d; ptp69D; ptp69d; ptp69; rptp69d", "protein_names_uniprotkb": "Tyrosine-protein phosphatase 69D; 3.1.3.48; DPTP; Protein-tyrosine-phosphate phosphohydrolase", "protein_names_refseq": "CG10975-PA; Ptp69D-PA; protein tyrosine phosphatase 69D, isoform A; protein tyrosine phosphatase PTP69D", "tax_id": 7227, "disease": "severe combined immunodeficiency 105 (Disease Ontology:DOID:0061074); hypertension (Disease Ontology:DOID:10763); multiple sclerosis (Disease Ontology:DOID:2377); severe combined immunodeficiency (Disease Ontology:DOID:627); retinal degeneration (Disease Ontology:DOID:8466); systemic lupus erythematosus (Disease Ontology:DOID:9074)", "pathway": " (dme:Dmel_CG10975)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;19349973;2554325", "class_list": "", "function": "Possible cell adhesion receptor., [UniProtKB]", "predicted_glycosites": 17, "predicted_n_glycosites": 17, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "Q8IGY3;Q9VU03", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" } ], "go_molecular_function": "GO:0005001 transmembrane receptor protein tyrosine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030424 axon", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0031175 neuron projection development;GO:0048813 dendrite morphogenesis;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P16620-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18102-1", "uniprot_id": [ { "id": "TLL_DROME", "url": "https://www.uniprot.org/uniprot/P18102", "type": "external" } ], "mass": 50549.0, "length": 452, "protein_name": "Protein tailless", "gene_name": "tll", "organism": "Fruit fly", "refseq_name": "tailless", "refseq_ac": [ { "id": "NP_524596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524596", "type": "external" } ], "gene_names_uniprotkb": "tll; CG1378; NR2E2", "gene_names_refseq": "CG1378; Dmel\\CG1378; NR2E2; TLL; Tailless; Tll; dm-tll; tll", "protein_names_uniprotkb": "Protein tailless; Nuclear receptor subfamily 2 group E member 2", "protein_names_refseq": "CG1378-PA; tailless; tailles; tll-PA", "tax_id": 7227, "disease": "brain cancer (Disease Ontology:DOID:1319)", "pathway": " (dme:Dmel_CG1378); (R-DME-383280)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10357938;10731132;12537572;2364433;8430097", "class_list": "", "function": "Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. This receptor binds to the consensus sequence [AG][AG]AAGTCAA. Plays a key role in the establishment of non-metameric domains at the anterior and posterior poles of the embryo. It may also play a role in the nervous system. The maternal terminal pathway activates the tll gene in the termini; TLL activity then represses segmentation and activates terminal-specific genes in these domains. Involved in the regulation of early eye development. In the embryonic visual system anlage drives cells to optic lobe as opposed to Bolwig's organ fate., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4V6W1;Q9VA33", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0004879 nuclear receptor activity;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001708 cell fate specification;GO:0002121 inter-male aggressive behavior;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P18102-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18173-1", "uniprot_id": [ { "id": "DHGL_DROME", "url": "https://www.uniprot.org/uniprot/P18173", "type": "external" } ], "mass": 66835.0, "length": 612, "protein_name": "Glucose dehydrogenase [FAD, quinone]", "gene_name": "Gld", "organism": "Fruit fly", "refseq_name": "glucose dehydrogenase, isoform A", "refseq_ac": [ { "id": "NP_477503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477503", "type": "external" } ], "gene_names_uniprotkb": "Gld; CG1152", "gene_names_refseq": "CG1152; Dmel\\CG1152; GDH; GLD; Gld; Go; gld; glucose dehydrogenase; l(3)84Cg", "protein_names_uniprotkb": "Glucose dehydrogenase [FAD, quinone]; 1.1.5.9", "protein_names_refseq": "CG1152-PA; Gld-PA; glucose dehydrogenase, isoform A; glucose dehydrogenase; glucose oxidase", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1152)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;2002763;2108306;3143620;33925313", "class_list": "", "function": "Essential for cuticular modification during development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A2U8U0K3;Q8SXV0;Q9VI87;U3PT72", "ec_number_list": [ { "id": "1.1.5.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.5.9", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0016491 oxidoreductase activity;GO:0140762 glucose dehydrogenase (FAD, quinone) activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006006 glucose metabolic process;GO:0046693 sperm storage;GO:0008364 pupal chitin-based cuticle development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P18173-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18432-1", "uniprot_id": [ { "id": "MLR_DROME", "url": "https://www.uniprot.org/uniprot/P18432", "type": "external" } ], "mass": 23714.0, "length": 222, "protein_name": "Myosin regulatory light chain 2", "gene_name": "Mlc2", "organism": "Fruit fly", "refseq_name": "myosin light chain 2", "refseq_ac": [ { "id": "NP_524586", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524586", "type": "external" } ], "gene_names_uniprotkb": "Mlc2; CG2184", "gene_names_refseq": "CG2184; DmMLC2; Dmel\\CG2184; Dmlc2; Dmlc; Ifm(3)99Eb; LC2; MLC 2; MLC-2; MLC2; MLC; MRLC; MYL2; Mlc2; Myosin; RLC1; RLC2; RLC; dMLC-2; dro MLC-2; l(3)99Eb; mlc-2; mlc2; myosin; p-MLC", "protein_names_uniprotkb": "Myosin regulatory light chain 2; MLC-2", "protein_names_refseq": "CG2184-PA; Mlc2-PA; muscle-specific myosin regulatory light chain; myosin II regulatory light chain; myosin II; myosin LC2; myosin alkali light chain 2; myosin light Chain-2; myosin light chain 2; myosin light chain; myosin light-chain 2", "tax_id": 7227, "disease": "infantile-onset myofibrillar myopathy 12 with cardiomyopathy (Disease Ontology:DOID:0051044); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); hypertrophic cardiomyopathy 10 (Disease Ontology:DOID:0110316); distal arthrogryposis type 1A (Disease Ontology:DOID:0111597); distal arthrogryposis type 1C (Disease Ontology:DOID:0112190)", "pathway": " (dme:Dmel_CG2184)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;18327897;3018498;3025224", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9VA98", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0032036 myosin heavy chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030016 myofibril;GO:0016460 myosin II complex", "go_biological_process": "GO:0009791 post-embryonic development;GO:0040011 locomotion;GO:0003012 muscle system process;GO:0030239 myofibril assembly;GO:0060361 flight", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P18432-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18502-1", "uniprot_id": [ { "id": "PTC_DROME", "url": "https://www.uniprot.org/uniprot/P18502", "type": "external" } ], "mass": 142831.0, "length": 1286, "protein_name": "Protein patched", "gene_name": "ptc", "organism": "Fruit fly", "refseq_name": "patched", "refseq_ac": [ { "id": "NP_523661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523661", "type": "external" } ], "gene_names_uniprotkb": "ptc; CG2411", "gene_names_refseq": "BcDNA:RH36596; CG2411; Conf; Dmel\\CG2411; PTC; Patched; Ptc_Dm; Ptch; Ptc; com4; dPtc; l(2)k02507; pat; ptch; ptc; rubr; tuf", "protein_names_uniprotkb": "Protein patched; Hedgehog receptor ptc", "protein_names_refseq": "CG2411-PA; compaction defects 4; confused; patched; patch; ptc-PA; rubberneck; tufted", "tax_id": 7227, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); medulloblastoma (Disease Ontology:DOID:0050902); nevoid basal cell carcinoma syndrome 1 (Disease Ontology:DOID:0070365); spina bifida (Disease Ontology:DOID:0080016); holoprosencephaly 7 (Disease Ontology:DOID:0110876); nasopharyngitis (Disease Ontology:DOID:10460); stomach cancer (Disease Ontology:DOID:10534); coloboma (Disease Ontology:DOID:12270); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); pancreatic cancer (Disease Ontology:DOID:1793); nevoid basal cell carcinoma syndrome (Disease Ontology:DOID:2512); basal cell carcinoma (Disease Ontology:DOID:2513); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910); hyperglycemia (Disease Ontology:DOID:4195); holoprosencephaly (Disease Ontology:DOID:4621); gallbladder carcinoma (Disease Ontology:DOID:4948); basaloid squamous cell carcinoma (Disease Ontology:DOID:5522); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dme:Dmel_CG2411); (R-DME-209214); (R-DME-209338); (R-DME-5610787); (R-DME-5632681); (R-DME-5632684)", "pathway_count": 6, "publication_count": 27, "publication_id_list": "10731132;10966113;12537572;12663920;12783860;14523402;14597665;14614827;14636583;15300262;15563523;15592457;15598741;15616566;15875013;16041759;16630821;17077139;17182028;24302888;24768000;2582494;2797178;31636957;8898207;8906787;8906794", "class_list": "", "function": "Segmentation polarity protein, which inhibits the smoothened signaling pathway by acting as a receptor for hedgehog morphogen (PubMed:10966113, PubMed:24302888, PubMed:2582494, PubMed:2797178, PubMed:8898207). In absence of hedgehog, acts as an inhibitor of smoothened protein (smo) by preventing smo access to cholesterol: mechanistically, acts as a cholesterol transporter, which depeletes cholesterol from the outer leaflet of plasma membrane, thereby preventing cholesterol-binding to the extracellular CRD region of smo (By similarity). Hedgehog-binding inhibits ptc cholesterol transporter activity, promoting smo activation by cholesterol and transduction of the smoothened signaling pathway (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 7, "predicted_n_glycosites": 5, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 21, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q9V4W3", "ec_number_list": [], "go_molecular_function": "GO:0097108 hedgehog family protein binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0070300 phosphatidic acid binding;GO:0008158 hedgehog receptor activity;GO:0005119 smoothened binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0030139 endocytic vesicle;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0055088 lipid homeostasis;GO:0007346 regulation of mitotic cell cycle;GO:0042981 regulation of apoptotic process;GO:0007411 axon guidance;GO:0035332 positive regulation of hippo signaling", "synthesized_glycan_count": 0, "hit_score": 2.8, "record_id": "P18502-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18929-1", "uniprot_id": [ { "id": "NU1M_DROME", "url": "https://www.uniprot.org/uniprot/P18929", "type": "external" } ], "mass": 35957.0, "length": 312, "protein_name": "NADH-ubiquinone oxidoreductase chain 1", "gene_name": "mt:ND1", "organism": "Fruit fly", "refseq_name": "NADH dehydrogenase subunit 1", "refseq_ac": [ { "id": "YP_009047278", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_009047278", "type": "external" } ], "gene_names_uniprotkb": "mt:ND1; CG34092; ND1", "gene_names_refseq": "ND1; mt:ND1", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 1; 7.1.1.2; NADH dehydrogenase subunit 1", "protein_names_refseq": "NADH dehydrogenase subunit 1", "tax_id": 7227, "disease": "Wolfram syndrome (Disease Ontology:DOID:10632); Alzheimer's disease (Disease Ontology:DOID:10652); renal hypertension (Disease Ontology:DOID:1073); anterior ischemic optic neuropathy (Disease Ontology:DOID:12010); Friedreich ataxia (Disease Ontology:DOID:12705); toxic shock syndrome (Disease Ontology:DOID:14115); Parkinson's disease (Disease Ontology:DOID:14330); multiple sclerosis (Disease Ontology:DOID:2377); bipolar disorder (Disease Ontology:DOID:3312); MELAS syndrome (Disease Ontology:DOID:3687); peripheral nervous system disease (Disease Ontology:DOID:574); Leber hereditary optic neuropathy (Disease Ontology:DOID:705); rheumatoid arthritis (Disease Ontology:DOID:7148); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG34092); (R-DME-5419276); (R-DME-611105); (R-DME-6799198)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "18727704;22851652;22863313;25294837;3130291;8825764", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9MGN3", "ec_number_list": [ { "id": "7.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.9", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" } ], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P18929-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18933-1", "uniprot_id": [ { "id": "NU6M_DROME", "url": "https://www.uniprot.org/uniprot/P18933", "type": "external" } ], "mass": 20075.0, "length": 174, "protein_name": "NADH-ubiquinone oxidoreductase chain 6", "gene_name": "mt:ND6", "organism": "Fruit fly", "refseq_name": "NADH dehydrogenase subunit 6", "refseq_ac": [ { "id": "YP_009047276", "url": "https://www.ncbi.nlm.nih.gov/protein/YP_009047276", "type": "external" } ], "gene_names_uniprotkb": "mt:ND6; ND6", "gene_names_refseq": "ND6; mt:ND6", "protein_names_uniprotkb": "NADH-ubiquinone oxidoreductase chain 6; 7.1.1.2; NADH dehydrogenase subunit 6", "protein_names_refseq": "NADH dehydrogenase subunit 6", "tax_id": 7227, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); lactic acidosis (Disease Ontology:DOID:3650); Leber hereditary optic neuropathy (Disease Ontology:DOID:705)", "pathway": " (dme:Dmel_CG34089); (R-DME-5419276); (R-DME-611105); (R-DME-6799198)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10903372;11298822;3130291;8825764", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7HM97", "ec_number_list": [ { "id": "7.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.9", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" } ], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P18933-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19018-1", "uniprot_id": [ { "id": "TRA2_DROME", "url": "https://www.uniprot.org/uniprot/P19018", "type": "external" } ], "mass": 31031.0, "length": 264, "protein_name": "Transformer-2 sex-determining protein", "gene_name": "tra2", "organism": "Fruit fly", "refseq_name": "transformer 2, isoform B", "refseq_ac": [ { "id": "NP_476763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476763", "type": "external" } ], "gene_names_uniprotkb": "tra2; CG10128; tra-2", "gene_names_refseq": "CG10128; Dmel\\CG10128; TRA 2; TRA-2; TRA2; Tra-2; Tra2; tra-2; tra2", "protein_names_uniprotkb": "Transformer-2 sex-determining protein", "protein_names_refseq": "CG10128-PB; Transformer-2; tra2-PB; transformer 2, isoform B; transformer 2; transformer2", "tax_id": 7227, "disease": "macular degeneration (Disease Ontology:DOID:4448)", "pathway": " (dme:Dmel_CG10128); (R-DME-72163); (R-DME-72203); (R-DME-9013418); (R-DME-9013422); (R-DME-9770562)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "10731132;12537569;12537572;1674449;18327897;2116360;2120049;2493992;3144434;7867927;8124712;8334698;9418892", "class_list": "", "function": "Required for female sex determination in somatic cells and for spermatogenesis in male germ cells. Positive regulator of female-specific splicing and/or polyadenylation of doublesex (dsx) pre-mRNA. Splicing requires an enhancer complex, dsxRE (dsx repeat element: which contains six copies of a 13-nucleotide repeat and a purine-rich enhancer (PRE)). DsxRE is formed through cooperative interactions between tra, tra2 and the sr proteins, and these interactions require both the repeat sequences and PRE. PRE is required for specific binding of tra2 to the dsxRE. Protein-RNA and protein-protein interactions are involved in tra-2 dependent activation and repression of alternative splicing. Together with tra-2, plays a role in switching fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 13, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4UZH1;Q0E977;Q9V734", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005681 spliceosomal complex;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0007530 sex determination;GO:0006397 mRNA processing;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0022414 reproductive process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P19018-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20349-1", "uniprot_id": [ { "id": "JANB_DROME", "url": "https://www.uniprot.org/uniprot/P20349", "type": "external" } ], "mass": 15860.0, "length": 140, "protein_name": "Sex-regulated protein janus-B", "gene_name": "janB", "organism": "Fruit fly", "refseq_name": "janus B", "refseq_ac": [ { "id": "NP_476584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476584", "type": "external" } ], "gene_names_uniprotkb": "janB; CG7931", "gene_names_refseq": "CG31024; CG7931; Dmel\\CG7931; Jan-B; Jan; bs30f02.y1; jan B; janB; janus; jan", "protein_names_uniprotkb": "Sex-regulated protein janus-B", "protein_names_refseq": "CG7931-PA; janB-PA; janus B; janusB; janus", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7931)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;16951084;2503707", "class_list": "", "function": "JanA and janB regulate somatic sex differentiation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0ANH4;A0ANH5;A0ANH6;A0ANH7;A0ANH8;A0ANI2;Q9VAB7", "ec_number_list": [], "go_molecular_function": "GO:0101006 protein histidine phosphatase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0030154 cell differentiation;GO:0007548 sex differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P20349-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20353-1", "uniprot_id": [ { "id": "GNAI_DROME", "url": "https://www.uniprot.org/uniprot/P20353", "type": "external" } ], "mass": 40596.0, "length": 355, "protein_name": "G protein alpha i subunit", "gene_name": "Galphai", "organism": "Fruit fly", "refseq_name": "G protein alpha subunit i", "refseq_ac": [ { "id": "NP_477502", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477502", "type": "external" } ], "gene_names_uniprotkb": "Galphai; CG10060; G-OA65C; G-ialpha65A", "gene_names_refseq": "CG10060; DG[[alpha1]]; DGalpha1; Dmel\\CG10060; G(alphai); G-alpha-65A; G-ia65A; G-ialpha65A; G-ialpha65a; G-oalpha65A; GNAI1/2/3; G[[alphai]]; G[[i]]alpha; G[[i]]; Gai; Galpha i; Galpha65A; GalphaI; Galpha[[i65A]]; Galpha[[i]]65A; Galpha[[i]]; Galphai/o; Galphaiota65A; Galphai; Gi-alpha; Gialpha; Gi; galphai; i", "protein_names_uniprotkb": "G protein alpha i subunit; Guanine nucleotide-binding protein G(i) subunit alpha 65A", "protein_names_refseq": "CG10060-PA; G protein I a-subunit 65A; G protein alpha i subunit; G protein alpha o subunit 65A; G protein alpha subunit i; G protein alpha subunit; G protein alpha-subunit; G protein alphai subunit 65A; G protein alphai subunit; G protein alphao subunit 65A; Galphai-PA", "tax_id": 7227, "disease": "cone-rod dystrophy (Disease Ontology:DOID:0050572); cardiomyopathy (Disease Ontology:DOID:0050700); achromatopsia 4 (Disease Ontology:DOID:0110010); congenital stationary night blindness 1G (Disease Ontology:DOID:0110714); congenital stationary night blindness autosomal dominant 3 (Disease Ontology:DOID:0110715); inflammatory bowel disease 12 (Disease Ontology:DOID:0110887); hypertension (Disease Ontology:DOID:10763); color blindness (Disease Ontology:DOID:13399); achromatopsia (Disease Ontology:DOID:13911); McCune Albright syndrome (Disease Ontology:DOID:1858); night blindness (Disease Ontology:DOID:8499)", "pathway": " (dme:Dmel_CG10060); (R-DME-170670); (R-DME-418594); (R-DME-418597)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10079238;10731132;12537569;12537572;15937221;3136172", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Plays a role in glial cell differentiation during embryogenesis; loco, Galphao and the G protein-coupled receptor, moody, are required in the surface glia to achieve effective insulation of the nerve cord., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VS04", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0045179 apical cortex;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0051294 establishment of spindle orientation;GO:0007186 G protein-coupled receptor signaling pathway;GO:0019722 calcium-mediated signaling;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0032880 regulation of protein localization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P20353-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20432-1", "uniprot_id": [ { "id": "GSTD1_DROME", "url": "https://www.uniprot.org/uniprot/P20432", "type": "external" } ], "mass": 23866.0, "length": 209, "protein_name": "Glutathione S-transferase D1", "gene_name": "GstD1", "organism": "Fruit fly", "refseq_name": "glutathione S transferase D1, isoform B", "refseq_ac": [ { "id": "NP_001034042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034042", "type": "external" } ], "gene_names_uniprotkb": "GstD1; CG10045; GSTD1-1; GST; Gst1", "gene_names_refseq": "CG10045; D1; DmGST-1; DmGST1; DmGSTD1-1; DmGSTD1; DmGst1; Dmel\\CG10045; G-S-T; GST-1; GST-D1; GST1-1; GST1; GSTD1; GSTase; GST; GSt1-1; Gst-D1; Gst1-1; Gst1.1; Gst1; GstD1; GstD; Gst; T5; dGSTT2; dGstD1; dmGSTD1; gst-D1-1; gst-D; gstD1; gstD; gstd1; gst", "protein_names_uniprotkb": "Glutathione S-transferase D1; 2.5.1.18; 4.5.1.1; DDT-dehydrochlorinase", "protein_names_refseq": "CG10045-PB; Glutathione-S-transferase 1; GstD1-PB; glutathione S transferase D1, isoform B; glutathione S transferase D; glutathione S-transferase 1; glutathione S-transferase D1; glutathione S-transferase-D1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10045)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10731132;12537569;12537572;15952742;1872839;20417639;22082028;2296588;7683659", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:20417639, PubMed:22082028). Has DDT dehydrochlorinase activity (PubMed:20417639). May be involved in detoxification (PubMed:22082028)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4JFI6;Q8MR98;Q9TX88;Q9VG99", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.5.1.1", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0004602 glutathione peroxidase activity;GO:0018833 DDT-dehydrochlorinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P20432-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20478-1", "uniprot_id": [ { "id": "GLNA2_DROME", "url": "https://www.uniprot.org/uniprot/P20478", "type": "external" } ], "mass": 41304.0, "length": 369, "protein_name": "Glutamine synthetase 2, cytoplasmic", "gene_name": "Gs2", "organism": "Fruit fly", "refseq_name": "glutamine synthetase 2, isoform E", "refseq_ac": [ { "id": "NP_001285122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285122", "type": "external" } ], "gene_names_uniprotkb": "Gs2; CG1743; DmGS2; Dmel\\CG1743; Dmel_CG1743; GS2; GsII; gs-c; gs2", "gene_names_refseq": "CG1743; DmGS2; Dmel\\CG1743; GS2; Gs2; GsII; gs-c; gs2", "protein_names_uniprotkb": "Glutamine synthetase 2, cytoplasmic; 6.3.1.2; GS-c; Glutamate--ammonia ligase 2", "protein_names_refseq": "CG1743-PE; Glutamate-ammonia ligase; Gs2-PE; cytoplasmic glutamine synthetase; glutamine synthase 2; glutamine synthetase 2, isoform E; glutamine synthetase 2", "tax_id": 7227, "disease": "congenital glutamine deficiency (Disease Ontology:DOID:0070544); developmental and epileptic encephalopathy 116 (Disease Ontology:DOID:0070545); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); heart disease (Disease Ontology:DOID:114); Huntington's disease (Disease Ontology:DOID:12858); epilepsy (Disease Ontology:DOID:1826); transient cerebral ischemia (Disease Ontology:DOID:224); temporal lobe epilepsy (Disease Ontology:DOID:3328); middle cerebral artery infarction (Disease Ontology:DOID:3525); liver disease (Disease Ontology:DOID:409); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); diabetic retinopathy (Disease Ontology:DOID:8947); amino acid metabolic disorder (Disease Ontology:DOID:9252); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG1743); (R-DME-210455); (R-DME-8964539)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;1969491;25589440;26109356;26109357;2897195;33327463;7896146", "class_list": "", "function": "Glutamine synthetase, a component of the Glutamate-Glutamine Cycle (GGC)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C8VV58;Q494K4;Q8IR90;Q95SM4;Q9VYZ0;X2JJG8", "ec_number_list": [ { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004356 glutamine synthetase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007416 synapse assembly;GO:0006542 glutamine biosynthetic process;GO:0006538 L-glutamate catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P20478-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22265-1", "uniprot_id": [ { "id": "TSH_DROME", "url": "https://www.uniprot.org/uniprot/P22265", "type": "external" } ], "mass": 100651.0, "length": 954, "protein_name": "Protein teashirt", "gene_name": "tsh", "organism": "Fruit fly", "refseq_name": "teashirt", "refseq_ac": [ { "id": "NP_523615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523615", "type": "external" } ], "gene_names_uniprotkb": "tsh; CG1374", "gene_names_refseq": "CG1374; Dmel\\CG1374; T shirt; TSH; Tsh; ae[l]; ae; l(2)04319; l(2)B4-2-12; tsh", "protein_names_uniprotkb": "Protein teashirt", "protein_names_refseq": "CG1374-PA; T-shirt; aeroplane; teashirt; tsh-PA", "tax_id": 7227, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)", "pathway": " (dme:Dmel_CG1374); (R-DME-390193)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10731132;10842058;11429289;12537572;1360402;15110046;15936749;17889654;18256197;18258485;18258486;18313299;18327897;1846092;19762509;7607071;7925029;8951796;9707400", "class_list": "", "function": "Homeotic protein that acts downstream of Arm in the Wg cascade during embryogenesis to determine segment identity throughout the entire trunk. Acts cooperatively with other trunk homeotic proteins to repress head homeotic genes and therefore repress head segmental identity. Necessary, in combination with Scr, for the formation of the prothoracic segment. Promotes eye development in the dorsal region of the eye disk and suppresses eye development in the ventral region in combination with Wg-signaling and several early dorso-ventral eye patterning genes. Required for proper development of proximal leg segments. Has differential functions along the dorso-ventral axs of the antennal and leg disks. May play a role in wing hinge development. Possible involvement in chromatin structure for modulation of transcription. Binds DNA and can act as both a transcriptional repressor and activator. Positively regulates its own expression as well as that of Dll. Negatively regulates the expression of mod. Required for Wg-mediated transcriptional repression of Ubx in the midgut. Also represses transcription of lab in the midgut and is necessary for the proper formation of anterior and central midgut structures. Tiptop (tio) and teashirt (tsh) have, on the whole, common activities. Tio and tsh repress each other's expression and tsh has a crucial role for trunk patterning that is in part masked by ectopic expression of tiptop. Both genes share a common activity required for the activation of Ser and svb and the maintenance of en and wg., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A8E6H0;Q6AWP7;Q7KRS3;Q9V9Q0", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0048749 compound eye development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "P22265-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22711-1", "uniprot_id": [ { "id": "TIN_DROME", "url": "https://www.uniprot.org/uniprot/P22711", "type": "external" } ], "mass": 46066.0, "length": 416, "protein_name": "Muscle-specific homeobox protein tinman", "gene_name": "tin", "organism": "Fruit fly", "refseq_name": "tinman", "refseq_ac": [ { "id": "NP_524433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524433", "type": "external" } ], "gene_names_uniprotkb": "tin; CG7895; msh2", "gene_names_refseq": "CG7895; DROHOXHK4; DROHOXNK4; DmNK-4; Dmel\\CG7895; HOX; NK-4/msh-2; NK-4; NK4/msh-2; NK4; NKX2.5; TIN; Tinman; Tin; msh-2; msh2; tin/NK4; tin", "protein_names_uniprotkb": "Muscle-specific homeobox protein tinman; Msh-2; NK-4", "protein_names_refseq": "CG7895-PA; muscle-specific-homeodomain-2; tin-PA; tinman", "tax_id": 7227, "disease": "atrial heart septal defect 7 (Disease Ontology:DOID:0110112); congenital heart disease (Disease Ontology:DOID:1682); pulmonary fibrosis (Disease Ontology:DOID:3770); tetralogy of Fallot (Disease Ontology:DOID:6419); hypoplastic left heart syndrome (Disease Ontology:DOID:9955)", "pathway": " (dme:Dmel_CG7895)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;12537572;15126403;1982429;2573058;32950464;7915669;9694800", "class_list": "", "function": "DNA binding protein (PubMed:9694800). Acts synergistically with the Mad-Med transcription factor complex to regulate certain dpp-responsive genes (PubMed:9694800). Required for the development of heart and visceral muscle; for the formation of somatic muscles. Has a crucial function in the early mesodermal subdivisions., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B6IDS0;Q6AWK6;Q6UKJ7;Q6UKK8;Q6UKL1;Q6UKL4;Q6UKL5;Q9TY85;Q9VDA7", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0055007 cardiac muscle cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P22711-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22769-1", "uniprot_id": [ { "id": "PSA71_DROME", "url": "https://www.uniprot.org/uniprot/P22769", "type": "external" } ], "mass": 27973.0, "length": 249, "protein_name": "Proteasome subunit alpha type-7-1", "gene_name": "Prosalpha4", "organism": "Fruit fly", "refseq_name": "proteasome alpha4 subunit", "refseq_ac": [ { "id": "NP_525092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525092", "type": "external" } ], "gene_names_uniprotkb": "Prosalpha4; CG3422; PROS-28.1; Pros28.1", "gene_names_refseq": "28.1Pros; 3422; Alpha-4; CG3422; Dmel\\CG3422; PROS-28.1; PROS-Dm28.1; PROSA-28.1; PSA4_DROME; Pros-Dm28.1; Pros28.1; Pros28; Prosalpha4; a4; alpha-4; alpha4_dm; alpha4; pros28.1", "protein_names_uniprotkb": "Proteasome subunit alpha type-7-1; PROS-Dm28.1; Proteasome 28 kDa subunit 1", "protein_names_refseq": "20s proteasome; CG3422-PA; Prosalpha4-PA; alpha-subunit of 20S proteasome; alpha4; proteasome 28kD subunit 1; proteasome alpha4 subunit", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3422); (R-DME-1169091); (R-DME-1234176); (R-DME-1236974); (R-DME-1236978); (R-DME-174084); (R-DME-174154); (R-DME-174178); (R-DME-174184); (R-DME-187577); (R-DME-195253); (R-DME-202424); (R-DME-209360); (R-DME-209406); (R-DME-209461); (R-DME-216167); (R-DME-2467813); (R-DME-2871837); (R-DME-350562); (R-DME-382556); (R-DME-432395); (R-DME-432524); (R-DME-432626); (R-DME-450408); (R-DME-4608870); (R-DME-4641257); (R-DME-4641258); (R-DME-5358346); (R-DME-538864); (R-DME-5607761); (R-DME-5607764); (R-DME-5610780); (R-DME-5610785); (R-DME-5632684); (R-DME-5658442); (R-DME-5676590); (R-DME-5689603); (R-DME-5689880); (R-DME-68867); (R-DME-68949); (R-DME-69017); (R-DME-69601); (R-DME-75815); (R-DME-8854050); (R-DME-8939236); (R-DME-8939902); (R-DME-8941858); (R-DME-8948751); (R-DME-8951664); (R-DME-9020702); (R-DME-9755511); (R-DME-9762114); (R-DME-983168); (R-DME-9907900); (R-DME-9912633); (R-DME-9929491); (R-DME-9932298); (R-DME-9954709)", "pathway_count": 58, "publication_count": 40, "publication_id_list": "10102270;10417378;10458606;10481010;10731132;11585911;12231619;12432393;12442174;12537569;12537572;12973300;1374331;15178801;15258584;15331761;15579695;16139204;16299518;16326393;16386907;16543224;16603629;16651542;16740475;16794082;17102630;17925225;18327897;18519643;18593878;19185492;2169443;23622245;7705656;8948598;9025065;9215627;9553105;9990853", "class_list": "", "function": "The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VXI9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000502 proteasome complex;GO:0019773 proteasome core complex, alpha-subunit complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 4.1, "record_id": "P22769-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22808-1", "uniprot_id": [ { "id": "VND_DROME", "url": "https://www.uniprot.org/uniprot/P22808", "type": "external" } ], "mass": 76422.0, "length": 723, "protein_name": "Homeobox protein vnd", "gene_name": "vnd", "organism": "Fruit fly", "refseq_name": "ventral nervous system defective, isoform A", "refseq_ac": [ { "id": "NP_476786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476786", "type": "external" } ], "gene_names_uniprotkb": "vnd; CG6172; Dm vnd; Dm-NK2; Dmel\\CG6172; Dmel_CG6172; EC6; EG:118B3.1; HDC16822; NK-2; NK2; Nkx2; VND; Vnd; dNK-2; l(1)1Bf; l(1)EA142; l(1)EC6; l(1)GA100; l(1)GA122; l(1)RC24; l(1)VA208; l(1)VE769; lab; nk-2", "gene_names_refseq": "CG6172; Dm vnd; Dm-NK2; Dmel\\CG6172; EC6; EG:118B3.1; HDC16822; NK-2; NK2; Nkx2; VND; Vnd; dNK-2; l(1)1Bf; l(1)EA142; l(1)EC6; l(1)GA100; l(1)GA122; l(1)RC24; l(1)VA208; l(1)VE769; lab; nk-2; vnd/NK-2; vnd", "protein_names_uniprotkb": "Homeobox protein vnd; Homeobox protein NK-2; Protein ventral nervous system defective", "protein_names_refseq": "CG6172-PA; HDC16822; ventral nerve cord defective; ventral nervous system condensation defective; ventral nervous system defective, isoform A; ventral nervous system defective; ventral neuroblasts defective; ventral neurons defective; vnd-PA", "tax_id": 7227, "disease": "cancer (Disease Ontology:DOID:162); demyelinating disease (Disease Ontology:DOID:3213)", "pathway": " (dme:Dmel_CG6172)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10731132;10731137;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;2573058;26109356;26109357;7625694;7628450;7643404;9154919", "class_list": "", "function": "Probable transcriptional regulator involved in the regulation of the proneural AS-C genes and the neurogenic genes of the enhancer of split complex. Could specifically activate proneural genes in the ventral-most neuroectoderm., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q24589;Q26436;Q9UB43;Q9W5F0", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0140297 DNA-binding transcription factor binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021782 glial cell development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P22808-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22816-1", "uniprot_id": [ { "id": "MYOD_DROME", "url": "https://www.uniprot.org/uniprot/P22816", "type": "external" } ], "mass": 36185.0, "length": 332, "protein_name": "Myogenic-determination protein", "gene_name": "nau", "organism": "Fruit fly", "refseq_name": "nautilus, isoform A", "refseq_ac": [ { "id": "NP_476650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476650", "type": "external" } ], "gene_names_uniprotkb": "nau; CG10250; MYD", "gene_names_refseq": "CG10250; Dmel\\CG10250; Dmyd; MYOD; Mdrf; MyoD; NAU; Nau; nau", "protein_names_uniprotkb": "Myogenic-determination protein; Protein nautilus; dMyd", "protein_names_refseq": "CG10250-PA; myogenic determination; nau-PA; nautilus, isoform A; nautilus", "tax_id": 7227, "disease": "congenital myopathy 17 (Disease Ontology:DOID:0081349); hypertension (Disease Ontology:DOID:10763); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); musculoskeletal system disease (Disease Ontology:DOID:17); congenital structural myopathy (Disease Ontology:DOID:422); congestive heart failure (Disease Ontology:DOID:6000); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG10250); (R-DME-525793)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537572;1902570;2176634", "class_list": "", "function": "May play an important role in the early development of muscle., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VCJ1", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0007517 muscle organ development;GO:0045663 positive regulation of myoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P22816-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22977-1", "uniprot_id": [ { "id": "CH16_DROME", "url": "https://www.uniprot.org/uniprot/P22977", "type": "external" } ], "mass": 14265.0, "length": 138, "protein_name": "Chorion protein S16", "gene_name": "Cp16", "organism": "Fruit fly", "refseq_name": "chorion protein 16", "refseq_ac": [ { "id": "NP_523981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523981", "type": "external" } ], "gene_names_uniprotkb": "Cp16; CG6533; s16", "gene_names_refseq": "CG6533; CP16; Cp16; Dmel\\CG6533; Dms16; Ov31; S16; X16715; cp16; melcp16; s16-1; s16", "protein_names_uniprotkb": "Chorion protein S16", "protein_names_refseq": "CG6533-PA; Cp16-PA; chorion prot 16; chorion protein 16", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6533)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;15917496;17244601;2509714", "class_list": "", "function": "Chorion membrane (egg shell) protein; plays a role in protecting the egg from the environment., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UM28;A8E6S3;A8E6T0;A8E6U5;Q3YMV2;Q9VSP4", "ec_number_list": [], "go_molecular_function": "GO:0005213 structural constituent of egg chorion", "go_cellular_component": "GO:0005576 extracellular region;GO:0042600 egg chorion", "go_biological_process": "GO:0007304 chorion-containing eggshell formation;GO:0046843 dorsal appendage formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P22977-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23226-1", "uniprot_id": [ { "id": "MA205_DROME", "url": "https://www.uniprot.org/uniprot/P23226", "type": "external" } ], "mass": 126669.0, "length": 1185, "protein_name": "205 kDa microtubule-associated protein", "gene_name": "Map205", "organism": "Fruit fly", "refseq_name": "Microtubule-associated protein 205, isoform C", "refseq_ac": [ { "id": "NP_001263154", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263154", "type": "external" } ], "gene_names_uniprotkb": "Map205; CG1483", "gene_names_refseq": "205-kDa MAP; 205K MAP; 205kD MAP; 205kDa MAP; CG1483; Dmel\\CG1483; MAP205; MAP4; Map205; map205", "protein_names_uniprotkb": "205 kDa microtubule-associated protein", "protein_names_refseq": "CG1483-PC; Map205-PC; Microtubule-associated protein 205, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1483)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537572;1703540;17372656;18327897;20146544", "class_list": "", "function": "May play an important role in the regulation of microtubule assembly and interaction., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4KI71;Q53YG1;Q8IMF5;Q9V9S1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005819 spindle;GO:0005874 microtubule;GO:0005875 microtubule associated complex;GO:0030496 midbody", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007098 centrosome cycle", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P23226-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23696-1", "uniprot_id": [ { "id": "PP2A_DROME", "url": "https://www.uniprot.org/uniprot/P23696", "type": "external" } ], "mass": 35469.0, "length": 309, "protein_name": "Serine/threonine-protein phosphatase PP2A", "gene_name": "mts", "organism": "Fruit fly", "refseq_name": "microtubule star, isoform B", "refseq_ac": [ { "id": "NP_001285724", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285724", "type": "external" } ], "gene_names_uniprotkb": "mts; 5559; CG7109; DmPp2A-28D; Dmel\\CG7109; Dmel_CG7109; ER2-6; MTS; Mts; PP2A 28D; PP2A C; PP2A-C; PP2AC; PP2A[C]; PP2A[[C]]; PP2Ac; PP2A; PP2a 28D; PP2a; PP2; Pp2A-28D; Pp2A; dPP2A-C; dPP2A; l(2)02496; l(2)s5286; pp2A", "gene_names_refseq": "5559; CG7109; DmPp2A-28D; Dmel\\CG7109; ER2-6; MTS/PP2A; MTS; Mts; PP2A 28D; PP2A C; PP2A-C; PP2A/MTS; PP2AC; PP2A[C]; PP2A[[C]]; PP2Ac; PP2A; PP2a 28D; PP2a; PP2; Pp2A-28D; Pp2A; dPP2A-C; dPP2A; l(2)02496; l(2)s5286; mts; pp2A", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase PP2A; 3.1.3.16; Protein microtubule star", "protein_names_refseq": "CG7109-PB; Microtubule-star; PP2A catalytic subunit; catalytic subunit C of type 2A protein phosphatase; microtubule star, isoform B; microtubule star; mts-PB; phosphatase 2A catalytic subunit; protein phosphatase 2A at 28D; protein phosphatase 2A", "tax_id": 7227, "disease": "prostate cancer (Disease Ontology:DOID:10283); Parkinson's disease (Disease Ontology:DOID:14330); congestive heart failure (Disease Ontology:DOID:6000); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dme:Dmel_CG7109); (R-DME-113501); (R-DME-1295596); (R-DME-195253); (R-DME-196299); (R-DME-209155); (R-DME-209190); (R-DME-209214); (R-DME-209360); (R-DME-209396); (R-DME-209413); (R-DME-209440); (R-DME-209461); (R-DME-2995383); (R-DME-389513); (R-DME-432553); (R-DME-432620); (R-DME-432626); (R-DME-5673000); (R-DME-5675221); (R-DME-6811558); (R-DME-69231); (R-DME-69273); (R-DME-975957); (R-DME-9833482); (R-DME-9860927)", "pathway_count": 26, "publication_count": 83, "publication_id_list": "10073940;10102270;10196136;10409506;10421629;10457025;10458606;10477300;10557210;10731132;10838083;10846164;11336703;11430804;11440719;11912487;11927557;11955435;11955436;12000790;12122057;12231619;12432393;12442174;12447397;12537568;12537569;12537572;12537573;12537574;12563262;12636921;12663920;12781135;12944510;14636582;14731402;14759367;14966281;14980226;15300262;15459103;15563523;15592457;15598741;15616566;15875013;16041759;16110336;16139204;16299518;16319317;16326393;16386907;16410523;16543224;16603629;16630821;17077139;17418796;17569856;17569867;17575052;17925225;18593878;18815259;2175718;25589440;26109356;26109357;32966759;37995689;7481773;8596938;8600384;8898207;8906787;8906794;8938123;8990193;9215627;9482888;9674431", "class_list": "", "function": "Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (By similarity). PP2A is the major phosphatase for microtubule-associated proteins (MAPs) (By similarity). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (PubMed:32966759). The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, mts/PP2A catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and Spt5, thereby preventing transcriptional elongation (PubMed:32966759, PubMed:37995689)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VLW4", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.1.1.233", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.233", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "5.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.5", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0019208 phosphatase regulator activity;GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000159 protein phosphatase type 2A complex", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0035330 regulation of hippo signaling;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation", "synthesized_glycan_count": 0, "hit_score": 8.4, "record_id": "P23696-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23938-1", "uniprot_id": [ { "id": "NG1_DROME", "url": "https://www.uniprot.org/uniprot/P23938", "type": "external" } ], "mass": 11371.0, "length": 107, "protein_name": "Protein new-glue 1", "gene_name": "ng1", "organism": "Fruit fly", "refseq_name": "new glue 1", "refseq_ac": [ { "id": "NP_476655", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476655", "type": "external" } ], "gene_names_uniprotkb": "ng1; CG10781; ngp", "gene_names_refseq": "CG10781; Dmel\\CG10781; EG:96G10.5; SC1; ng-1; ng1; ngp; ng", "protein_names_uniprotkb": "Protein new-glue 1; NG-1; Salivary glue protein homolog", "protein_names_refseq": "CG10781-PA; New glue1; nested; new glue 1; new glue protein; ng1-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10781)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;10731137;12537572;2120680", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V3M5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P23938-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24350-2", "uniprot_id": [ { "id": "IPOU_DROME", "url": "https://www.uniprot.org/uniprot/P24350", "type": "external" } ], "mass": 43704.0, "length": 396, "protein_name": "Inhibitory POU protein", "gene_name": "acj6", "organism": "Fruit fly", "refseq_name": "abnormal chemosensory jump 6, isoform D", "refseq_ac": [ { "id": "NP_001014743", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014743", "type": "external" } ], "gene_names_uniprotkb": "acj6; CG9151; Ipou", "gene_names_refseq": "ACJ6; Acj6; CG9151; Dmel\\CG9151; I-POU; Ipou; acj6; tI-POU", "protein_names_uniprotkb": "Inhibitory POU protein; Abnormal chemosensory jump 6 protein; I-POU", "protein_names_refseq": "CG9151-PD; abnormal chemosensory jumb; abnormal chemosensory jump 6, isoform D; abnormal chemosensory jump 6; acj6-PD; altered chemosensory jump 6; twin of I-POU", "tax_id": 7227, "disease": "autosomal dominant nonsyndromic deafness 15 (Disease Ontology:DOID:0110546)", "pathway": " (dme:Dmel_CG9151); (R-DME-6804759)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10069339;10731132;12537572;1346754;1673230;8986770", "class_list": "", "function": "Modulates gene transcription; simultaneously generates both a specific activator and an inhibitor of gene transcription, capable of modulating two distinct regulatory programs during neural development. Has a role in olfactory behavior., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O77214;Q26465;Q59E44;Q59E45;Q8IR36;Q9VXW1", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0003714 transcription corepressor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048813 dendrite morphogenesis;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P24350-2", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24785-1", "uniprot_id": [ { "id": "MLE_DROME", "url": "https://www.uniprot.org/uniprot/P24785", "type": "external" } ], "mass": 143661.0, "length": 1293, "protein_name": "Dosage compensation regulator mle", "gene_name": "mle", "organism": "Fruit fly", "refseq_name": "maleless, isoform A", "refseq_ac": [ { "id": "NP_476641", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476641", "type": "external" } ], "gene_names_uniprotkb": "mle; CG11680; nap", "gene_names_refseq": "CG11680; DDX9; Dmel\\CG11680; MLE; Mle; dDHX9; mak; mle; mll; mls; nap[ts]; nap", "protein_names_uniprotkb": "Dosage compensation regulator mle; 3.6.4.13; Protein male-less; Protein maleless; Protein no action potential", "protein_names_refseq": "CG11680-PA; male lethal; male-killer; male-lethal; maleless, isoform A; maleless-no-action potential; maleless; mle-PA; no action potential; no-action-potential", "tax_id": 7227, "disease": "autosomal dominant intellectual developmental disorder 75 (Disease Ontology:DOID:0061048); epilepsy (Disease Ontology:DOID:1826)", "pathway": " (dme:Dmel_CG11680); (R-DME-1810476); (R-DME-3134963); (R-DME-9770562); (R-DME-9833482)", "pathway_count": 5, "publication_count": 12, "publication_id_list": "10679323;10731132;11014199;12537572;1653648;23870142;23989663;25158899;26545078;30649456;30805612;9184214", "class_list": "", "function": "RNA helicase component of the male-specific lethal (MSL) histone acetyltransferase complex, a multiprotein complex essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation) (PubMed:1653648, PubMed:25158899, PubMed:26545078). Within the MSL complex, the helicase activity of mle remodels roX non-coding RNA (roX1 and roX2)s to promote assembly of the MSL complex (PubMed:23870142, PubMed:26545078, PubMed:30649456, PubMed:30805612). Able to unwind blunt-ended RNA duplexes and has specificity for uridine-rich nucleotides (PubMed:26545078)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 14, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86NQ4;Q9V9J1", "ec_number_list": [ { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0001069 regulatory region RNA binding;GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0000785 chromatin;GO:0005694 chromosome", "go_biological_process": "GO:2000765 regulation of cytoplasmic translation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization;GO:0048675 axon extension;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P24785-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25123-2", "uniprot_id": [ { "id": "GBRB_DROME", "url": "https://www.uniprot.org/uniprot/P25123", "type": "external" } ], "mass": 65656.0, "length": 606, "protein_name": "Gamma-aminobutyric acid receptor subunit beta", "gene_name": "Rdl", "organism": "Fruit fly", "refseq_name": "resistant to dieldrin, isoform F", "refseq_ac": [ { "id": "NP_001261616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261616", "type": "external" } ], "gene_names_uniprotkb": "Rdl; CG10537", "gene_names_refseq": "CG10537; CT29555; DGABAAR; DmRDL; DmRdl; Dmel\\CG10537; GABA-R; GABAAR; GABAR; GABA[[A]] receptor; GABA[[A]]-R; GABA[[A]]R; GABA[[A]]; GABAr; GABA; LCCH1; RDL; Rd1; Rdl; gaba; rdl", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit beta; GABA(A) receptor subunit beta; Protein cyclodiene resistance", "protein_names_refseq": "CG10537-PF; GABA A beta-subunit; GABA receptor; Rdl GABA[[A]] receptor; Rdl-PF; resistance to DieLdrin; resistant to dieldrin, isoform F; resistant to dieldrin", "tax_id": 7227, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); hyperekplexia 2 (Disease Ontology:DOID:0060697); autistic disorder (Disease Ontology:DOID:12849); epilepsy (Disease Ontology:DOID:1826); postpartum depression (Disease Ontology:DOID:9478); cocaine dependence (Disease Ontology:DOID:9975)", "pathway": " (dme:Dmel_CG10537); (R-DME-977443)", "pathway_count": 2, "publication_count": 23, "publication_id_list": "10731132;12537569;12537572;12805302;12907802;1651498;18093529;18223647;19038223;19193904;19230663;24068821;24241395;24823815;29174887;31535971;32075756;32339168;7527461;7684073;8016117;8389005;8882620", "class_list": "", "function": "Gamma-aminobutyric acid (GABA) receptor voltage channel subunit (PubMed:12805302, PubMed:24823815, PubMed:7527461, PubMed:8016117, PubMed:8389005, PubMed:8882620). GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel (PubMed:12805302, PubMed:7527461, PubMed:8389005). Together with glutamate receptor GluClalpha, plays an important role in the visual response by regulating the activity of ON/OFF-selective neurons (PubMed:31535971, PubMed:32075756). Plays a role in promoting sleep and sleep latency by regulating the activity of peptidergic PDF neurons (PubMed:18223647, PubMed:19038223, PubMed:19230663). In large ventral lateral clock neurons, clustering is mediated by Nlg4 and protein levels undergo daily degradation in response to the circadian clock (PubMed:24068821, PubMed:29174887). In neurons in the mushroom bodies, has a role in odor memory acquisition where it inhibits appetitive and aversive olfactory learning, probably upstream of Adcy1/adenylate cyclase 1 and GTPase activating protein Nf1 (PubMed:18093529, PubMed:19193904). In male-specific GABAergic neurons, plays a role in inhibiting male aggressive behavior during courtship (PubMed:24241395)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Gamma-aminobutyric acid (GABA) receptor voltage channel subunit., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P92138;Q24561;Q26302;Q7JPX8;Q8IQB5;Q8IQB6;Q961R4;Q9TX51;Q9VSV0", "ec_number_list": [], "go_molecular_function": "GO:0030594 neurotransmitter receptor activity;GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity", "go_cellular_component": "GO:0032589 neuron projection membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0042048 olfactory behavior;GO:0002121 inter-male aggressive behavior;GO:0006811 monoatomic ion transport;GO:0009612 response to mechanical stimulus;GO:0030431 sleep", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "P25123-2", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25455-3", "uniprot_id": [ { "id": "PIP1_DROME", "url": "https://www.uniprot.org/uniprot/P25455", "type": "external" } ], "mass": 146391.0, "length": 1318, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II", "gene_name": "Plc21C", "organism": "Fruit fly", "refseq_name": "phospholipase C at 21C, isoform G", "refseq_ac": [ { "id": "NP_001259818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259818", "type": "external" } ], "gene_names_uniprotkb": "Plc21C; CG4574; plc-21", "gene_names_refseq": "CG4574; Dmel\\CG4574; PLC-21C; PLC-21; PLC21C; PLC21c; PLC[[Beta]]; PLC; Plc21C; Plc21c; Plc21; Plcbeta21C; plc-21; plc21C; plc21c; plc21; plcbeta21c", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II; 3.1.4.11; Phosphoinositide phospholipase C", "protein_names_refseq": "CG4574-PG; Plc21C-PG; phospholipase C 21C; phospholipase C at 21C, isoform G; phospholipase c at 21c", "tax_id": 7227, "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908); developmental and epileptic encephalopathy 12 (Disease Ontology:DOID:0080459); spondylometaphyseal dysplasia with corneal dystrophy (Disease Ontology:DOID:0112303); Alzheimer's disease (Disease Ontology:DOID:10652); congenital heart disease (Disease Ontology:DOID:1682); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); acute myeloid leukemia (Disease Ontology:DOID:9119); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG4574); (R-DME-112043); (R-DME-1855204); (R-DME-416476)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;2061323", "class_list": "", "function": "The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZX5;M9PC05;Q0E8V1;Q7KTZ7;Q961D5;Q9VPN9", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0070050 neuron cellular homeostasis;GO:0016042 lipid catabolic process;GO:0051209 release of sequestered calcium ion into cytosol;GO:0048015 phosphatidylinositol-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P25455-3", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25722-1", "uniprot_id": [ { "id": "HS2ST_DROME", "url": "https://www.uniprot.org/uniprot/P25722", "type": "external" } ], "mass": 41273.0, "length": 349, "protein_name": "Heparin sulfate O-sulfotransferase", "gene_name": "Hs2st", "organism": "Fruit fly", "refseq_name": "heparan sulfate 2-O-sulfotransferase", "refseq_ac": [ { "id": "NP_477339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477339", "type": "external" } ], "gene_names_uniprotkb": "Hs2st; CG10234; HS-2OST", "gene_names_refseq": "CG10234; DmHs2st; Dmel\\CG10234; HS2ST; Hs2st-2; Hs2st; dHS2ST; dmHS-2OST; dmHs2st", "protein_names_uniprotkb": "Heparin sulfate O-sulfotransferase; 2.8.2.-; dmHS-2OST", "protein_names_refseq": "2-O sulfotransferase; CG10234-PA; HS 2-O-sulfotransferase; Hs2st-PA; heparan sulfate 2-O-sulfotransferase; heparan-sulfate-2-sulfotransferase", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10234); (R-DME-2022928)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;17227754;1936954", "class_list": "", "function": "Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS)., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9VIW4", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" } ], "go_molecular_function": "GO:0004394 heparan sulfate 2-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007165 signal transduction;GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0007424 open tracheal system development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P25722-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25723-1", "uniprot_id": [ { "id": "TLD_DROME", "url": "https://www.uniprot.org/uniprot/P25723", "type": "external" } ], "mass": 121780.0, "length": 1067, "protein_name": "Dorsal-ventral patterning protein tolloid", "gene_name": "tld", "organism": "Fruit fly", "refseq_name": "tolloid", "refseq_ac": [ { "id": "NP_524487", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524487", "type": "external" } ], "gene_names_uniprotkb": "tld; CG6868", "gene_names_refseq": "CG6868; CT21278; Dmel\\CG6868; TLD; Tld; Tolloid; dTld; tld", "protein_names_uniprotkb": "Dorsal-ventral patterning protein tolloid; 3.4.24.-", "protein_names_refseq": "CG6868-PA; tld-PA; tolloid", "tax_id": 7227, "disease": "atrial heart septal defect 6 (Disease Ontology:DOID:0110111); osteogenesis imperfecta type 13 (Disease Ontology:DOID:0110342); osteogenesis imperfecta (Disease Ontology:DOID:12347); congenital heart disease (Disease Ontology:DOID:1682); coronary artery disease (Disease Ontology:DOID:3393)", "pathway": " (dme:Dmel_CG6868); (R-DME-1474228); (R-DME-1650814); (R-DME-2214320); (R-DME-2243919)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "10731132;12537572;15872004;17119021;1840509;7600963", "class_list": "", "function": "Metalloprotease which cleaves TGF-beta family ligands daw, Actbeta and myo in vitro (PubMed:17119021). Cleavage of daw enhances its signaling activity (PubMed:17119021). Cleaves dorsal-ventral patterning protein sog (PubMed:15872004). Processes sog more efficiently than metalloprotease tld which also cleaves sog (PubMed:15872004). Required for normal dorsal development. TLD may interact physically with DPP-C protein., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 8, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q9VC46", "ec_number_list": [ { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.4.22.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "1.4.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.13", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0005518 collagen binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0030513 positive regulation of BMP signaling pathway;GO:0032927 positive regulation of activin receptor signaling pathway;GO:0009953 dorsal/ventral pattern formation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P25723-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28166-1", "uniprot_id": [ { "id": "ZFH1_DROME", "url": "https://www.uniprot.org/uniprot/P28166", "type": "external" } ], "mass": 116598.0, "length": 1054, "protein_name": "Zinc finger protein 1", "gene_name": "zfh1", "organism": "Fruit fly", "refseq_name": "Zn finger homeodomain 1, isoform B", "refseq_ac": [ { "id": "NP_476850", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476850", "type": "external" } ], "gene_names_uniprotkb": "zfh1; CG1322; zfh-1", "gene_names_refseq": "CG1322; Dmel\\CG1322; ZFH-1; ZFH1; ZFh1; Zfh-1; Zfh1a; Zfh1; l(3)00865; zfh-1; zfh1; zfl-1; zhf1", "protein_names_uniprotkb": "Zinc finger protein 1; Zinc finger homeodomain protein 1", "protein_names_refseq": "CG1322-PB; Zinc-finger homeodomain protein 1; Zn finger homeodomain 1, isoform B; Zn homeodomain 1; zfh1-PB; zinc finger homeodomain 1; zinc finger homeodomain protein-1; zinc finger homeodomain-1; zinc-finger homeobox gene; zinc-finger homeodomain1", "tax_id": 7227, "disease": "rheumatic heart disease (Disease Ontology:DOID:0050827); Mowat-Wilson syndrome (Disease Ontology:DOID:0060485); posterior polymorphous corneal dystrophy 3 (Disease Ontology:DOID:0110857); Hirschsprung's disease (Disease Ontology:DOID:10487); hypospadias (Disease Ontology:DOID:10892); Fuchs' endothelial dystrophy (Disease Ontology:DOID:11555); HTLV-1-associated myelopathy/tropical spastic paraparesis (Disease Ontology:DOID:321); T-cell adult acute lymphocytic leukemia (Disease Ontology:DOID:5602); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); acute myocardial infarction (Disease Ontology:DOID:9408)", "pathway": " (dme:Dmel_CG1322); (R-DME-9762293); (R-DME-9764725)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;1680376;18327897", "class_list": "", "function": "Involved in the development of the embryonic central nervous system, embryonic mesoderm and adult musculature., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q59DT3;Q6NP51;Q8MSQ8;Q9VA39;Q9VA40", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0046716 muscle cell cellular homeostasis;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P28166-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28466-1", "uniprot_id": [ { "id": "WNT5_DROME", "url": "https://www.uniprot.org/uniprot/P28466", "type": "external" } ], "mass": 112459.0, "length": 1004, "protein_name": "Protein Wnt-5", "gene_name": "Wnt5", "organism": "Fruit fly", "refseq_name": "Wnt oncogene analog 5, isoform B", "refseq_ac": [ { "id": "NP_001285407", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285407", "type": "external" } ], "gene_names_uniprotkb": "Wnt5; 5; CG6407; DWnt-3; DWnt-5; DWnt3; DWnt5; Dm-3; Dmel\\CG6407; Dmel_CG6407; Dwnt-3; Dwnt-5; Dwnt3; Dwnt5; WNT-5; WNT5; Wnt-3; Wnt3; Wnt; anon-WO03040301.228; wnt3; wnt5", "gene_names_refseq": "CG6407; DWnt-3/5; DWnt-3; DWnt-5; DWnt3/5; DWnt3; DWnt5; Dm DWnt3/5; Dm-3; Dmel\\CG6407; Dwnt-3; Dwnt-5; Dwnt3/5; Dwnt3; Dwnt5; WNT5; Wnt-3; Wnt3/5; Wnt3; Wnt5; Wnt; anon-WO03040301.228; wnt3; wnt5", "protein_names_uniprotkb": "Protein Wnt-5; dWnt-3; dWnt-5", "protein_names_refseq": "CG6407-PB; Wnt oncogene analog 5, isoform B; Wnt5-PB; wnt-oncogene-analog-3", "tax_id": 7227, "disease": "Robinow syndrome (Disease Ontology:DOID:0060254); autosomal dominant Robinow syndrome 1 (Disease Ontology:DOID:0060766); leiomyoma (Disease Ontology:DOID:127); colon cancer (Disease Ontology:DOID:219); endometrial carcinoma (Disease Ontology:DOID:2871)", "pathway": " (dme:Dmel_CG6407); (R-DME-201681); (R-DME-3238698); (R-DME-4086400); (R-DME-4608870); (R-DME-5099900); (R-DME-5140745)", "pathway_count": 7, "publication_count": 15, "publication_id_list": "10731132;11821428;12537568;12537572;12537573;12537574;12660735;1358729;1425336;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus (PubMed:1358729, PubMed:1425336). Probable developmental protein (PubMed:1358729, PubMed:1425336). May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (PubMed:1358729). Ligand of the putative inactive receptor tyrosine kinase drl/derailed involved in neuronal pathway recognition; acts as a repellent signal preventing the projection of anterior commissure axons across the midline into the posterior commissure (PubMed:12660735). May have a role in limb and CNS development; may be a downstream target of Dll that acts in the specification of these primordia (PubMed:1358729)., [UniProtKB, PubMed, PubMed, PubMed]; Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 13, "predicted_n_glycosites": 13, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q01535;Q9VWT4", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005109 frizzled binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0030425 dendrite", "go_biological_process": "GO:0007517 muscle organ development;GO:0030182 neuron differentiation;GO:0016055 Wnt signaling pathway;GO:0045773 positive regulation of axon extension;GO:0060070 canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P28466-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29681-1", "uniprot_id": [ { "id": "IMPE2_DROME", "url": "https://www.uniprot.org/uniprot/P29681", "type": "external" } ], "mass": 49809.0, "length": 466, "protein_name": "20-hydroxyecdysone protein", "gene_name": "ImpE2", "organism": "Fruit fly", "refseq_name": "Ecdysone-inducible gene E2", "refseq_ac": [ { "id": "NP_476580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476580", "type": "external" } ], "gene_names_uniprotkb": "ImpE2; CG1934; IMP-E2", "gene_names_refseq": "CG1934; Dmel\\CG1934; IMP-E2; Imp-E2; ImpE2", "protein_names_uniprotkb": "20-hydroxyecdysone protein; 20-HE", "protein_names_refseq": "CG1934-PA; Ecdysone-inducible gene E2; ImpE2-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1934)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;2115480", "class_list": "", "function": "Probably has an essential role in embryogenesis, induces morphogenesis of imaginal disks, and may participate in multimolecular aggregates., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 2, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9VZN9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0019898 extrinsic component of membrane", "go_biological_process": "GO:0007561 imaginal disc eversion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P29681-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29843-1", "uniprot_id": [ { "id": "HSP7A_DROME", "url": "https://www.uniprot.org/uniprot/P29843", "type": "external" } ], "mass": 70686.0, "length": 641, "protein_name": "Heat shock 70 kDa protein cognate 1", "gene_name": "Hsc70-1", "organism": "Fruit fly", "refseq_name": "heat shock protein 70 cognate 1, isoform A", "refseq_ac": [ { "id": "NP_524063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524063", "type": "external" } ], "gene_names_uniprotkb": "Hsc70-1; 143191_at; BcDNA:RH49358; CG8937; DmHsp70; Dmel\\CG8937; Dmel_CG8937; HSC-70; HSC1; HSC70-1; HSC70; HSP70cB1; HSP7A_DROME; Hsc1; Hsc70.1; Hsc70; Hsp-c1; Hsp70; dhsc70-1; dhsc70; hsc70", "gene_names_refseq": "143191_at; BcDNA:RH49358; CG8937; DmHsp70; Dmel\\CG8937; HSC-70; HSC1; HSC70-1; HSC70; HSP70cB1; HSP7A_DROME; Hsc1; Hsc70-1; Hsc70.1; Hsc70; Hsp-c1; Hsp70; dhsc70-1; dhsc70; hsc70", "protein_names_uniprotkb": "Heat shock 70 kDa protein cognate 1; Heat shock 70 kDa protein 70C", "protein_names_refseq": "70 kDa heat shock protein, cytosolic B 1; CG8937-PA; Hsc70-1-PA; heat shock protein 70 cognate 1, isoform A; heat shock protein cognate 1", "tax_id": 7227, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); stroke (Disease Ontology:DOID:0051061); lymphoma (Disease Ontology:DOID:0060058); congenital anomalies of the kidney and urinary tract (Disease Ontology:DOID:0080205); urinary tract infection (Disease Ontology:DOID:0080784); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); Parkinsonism (Disease Ontology:DOID:0080855); graft-versus-host disease (Disease Ontology:DOID:0081267); pneumoconiosis (Disease Ontology:DOID:10316); Alzheimer's disease (Disease Ontology:DOID:10652); renal hypertension (Disease Ontology:DOID:1073); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); paranoid schizophrenia (Disease Ontology:DOID:1229); vitiligo (Disease Ontology:DOID:12306); cardiovascular system disease (Disease Ontology:DOID:1287); Kawasaki disease (Disease Ontology:DOID:13378); toxic shock syndrome (Disease Ontology:DOID:14115); Parkinson's disease (Disease Ontology:DOID:14330); major depressive disorder (Disease Ontology:DOID:1470); cystic fibrosis (Disease Ontology:DOID:1485); status epilepticus (Disease Ontology:DOID:1824); atherosclerosis (Disease Ontology:DOID:1936); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); multiple sclerosis (Disease Ontology:DOID:2377); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); acute kidney failure (Disease Ontology:DOID:3021); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cervical cancer (Disease Ontology:DOID:4362); macular degeneration (Disease Ontology:DOID:4448); lung small cell carcinoma (Disease Ontology:DOID:5409); schizophrenia (Disease Ontology:DOID:5419); vascular dementia (Disease Ontology:DOID:8725); systemic lupus erythematosus (Disease Ontology:DOID:9074); colorectal cancer (Disease Ontology:DOID:9256); type 2 diabetes mellitus (Disease Ontology:DOID:9352); systolic heart failure (Disease Ontology:DOID:9651); senile cataract (Disease Ontology:DOID:9669); Meniere's disease (Disease Ontology:DOID:9849); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG8937); (R-DME-3371453); (R-DME-3371497); (R-DME-3371571)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;6804941;8514184", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 43, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9VUA7", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006457 protein folding;GO:0006950 response to stress;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P29843-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29993-1", "uniprot_id": [ { "id": "ITPR_DROME", "url": "https://www.uniprot.org/uniprot/P29993", "type": "external" } ], "mass": 319137.0, "length": 2837, "protein_name": "Inositol 1,4,5-trisphosphate receptor", "gene_name": "Itpr", "organism": "Fruit fly", "refseq_name": "inositol 1,4,5,-trisphosphate receptor, isoform C", "refseq_ac": [ { "id": "NP_001287180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287180", "type": "external" } ], "gene_names_uniprotkb": "Itpr; CG1063; InsP3R; Itp-r83A; dip", "gene_names_refseq": "CG1063; DIP; DmInsP[[3R]]; DmInsP[[3]]R; Dmel\\CG1063; IP3R; IP[[3]] receptor; IP[[3]]R; IP; ITP-r83A; ITPR1; ITPR; Ins3PR; InsP(3); InsP3R; InsP3; InsP[[3]]R; InsP[[3]]; Insp3R; Ip3R; Ip3r; Itp-R83A; Itp-R83a; Itp-r-83A; Itp-r42B; Itp-r83A; Itp-r[1]; Itp-r; ItpR; Itpr; anon-WO02059370.49; dIP3R; dIP[[3]]R; dip; ip3r; itpr-83; itpr; l(3)05616; l(3)itpr; l(3)j5B4", "protein_names_uniprotkb": "Inositol 1,4,5-trisphosphate receptor; IP3R; InsP3 receptor; InsP3R", "protein_names_refseq": "1, 4, 5-inositol trisphosphate receptor; CG1063-PC; IP[[3]] receptor; Inositol(1,4,5)-triphosphate receptor 42B; Ins(1,4,5)P[[3]] receptor; InsP[[3]] receptor; Itpr-PC; dm_IP3 receptor; inositol 1,4,5,-tris-phosphate receptor; inositol 1,4,5,-trisphosphate receptor, isoform C; inositol 1,4,5-triphosphate receptor; inositol 1,4,5-trisphosphate (InsP3) receptor; inositol 1,4,5-trisphosphate receptor; inositol triphosphate receptor 1; inositol trisphosphate receptor; inositol-1,3,5,-trisphosphate receptor; inositol-1,4,5-trisphosphate receptor; inositol-triphosphate receptor; ip3-receptor; type 1 InsP{3} receptor", "tax_id": 7227, "disease": "spinocerebellar ataxia 15 (Disease Ontology:DOID:0050965); spinocerebellar ataxia 29 (Disease Ontology:DOID:0050978); autism spectrum disorder (Disease Ontology:DOID:0060041); cardiac arrest (Disease Ontology:DOID:0060319); isolated anhidrosis with normal sweat glands (Disease Ontology:DOID:0060603); immunodeficiency 133 (Disease Ontology:DOID:0061096); Gillespie syndrome (Disease Ontology:DOID:0111578); pre-eclampsia (Disease Ontology:DOID:10591); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); Alzheimer's disease (Disease Ontology:DOID:10652); gestational diabetes (Disease Ontology:DOID:11714); Huntington's disease (Disease Ontology:DOID:12858); autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441); congenital heart disease (Disease Ontology:DOID:1682); transient cerebral ischemia (Disease Ontology:DOID:224); asthma (Disease Ontology:DOID:2841); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG1063); (R-DME-114508); (R-DME-139853); (R-DME-381676); (R-DME-5578775); (R-DME-9717207); (R-DME-983695)", "pathway_count": 7, "publication_count": 7, "publication_id_list": "10375644;10731132;12537572;1322910;1338312;28726639;29444420", "class_list": "", "function": "Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium (PubMed:1322910). Together with MCU, has a role in oxidative stress-induced ER-mitochondria calcium transfer (PubMed:28726639). May be involved in visual and olfactory transduction, and myoblast proliferation (PubMed:1322910). May be involved in ethanol tolerance (PubMed:29444420)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 18, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4LGN1;Q24309;Q9U981;Q9VNC8", "ec_number_list": [], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity;GO:0005509 calcium ion binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005790 smooth endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030667 secretory granule membrane", "go_biological_process": "GO:0010888 negative regulation of lipid storage;GO:0030322 stabilization of membrane potential;GO:0006979 response to oxidative stress;GO:0042594 response to starvation;GO:0055088 lipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P29993-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32845-1", "uniprot_id": [ { "id": "NULLO_DROME", "url": "https://www.uniprot.org/uniprot/P32845", "type": "external" } ], "mass": 24192.0, "length": 213, "protein_name": "Protein nullo", "gene_name": "nullo", "organism": "Fruit fly", "refseq_name": "nullo", "refseq_ac": [ { "id": "NP_511067", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_511067", "type": "external" } ], "gene_names_uniprotkb": "nullo; CG14426", "gene_names_refseq": "BcDNA:RE47733; CG14426; Dmel\\CG14426; Nullo; nullo", "protein_names_uniprotkb": "Protein nullo", "protein_names_refseq": "CG14426-PB; nullo-PB; nullo", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14426)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;1378418", "class_list": "", "function": "Actin-myosin network stability during cellularization. Might be involved in increasing actin-actin interactions or membrane-to-cytoskeleton attachments. nullo together with Sry-a and bnk may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W3S9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005911 cell-cell junction;GO:0005912 adherens junction", "go_biological_process": "GO:0016331 morphogenesis of embryonic epithelium;GO:0008360 regulation of cell shape;GO:0007043 cell-cell junction assembly;GO:0036089 cleavage furrow formation;GO:0007349 cellularization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P32845-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35005-1", "uniprot_id": [ { "id": "TRYE_DROME", "url": "https://www.uniprot.org/uniprot/P35005", "type": "external" } ], "mass": 27810.0, "length": 256, "protein_name": "Trypsin epsilon", "gene_name": "epsilonTry", "organism": "Fruit fly", "refseq_name": "epsilonTrypsin", "refseq_ac": [ { "id": "NP_525112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525112", "type": "external" } ], "gene_names_uniprotkb": "epsilonTry; CG18681; TRY-EPSILON", "gene_names_refseq": "CG18681; DmEpsilonTry; Dmel\\CG18681; EpsilonTry; SP88; Try; epsilonTrp; epsilonTry; epsilon", "protein_names_uniprotkb": "Trypsin epsilon; 3.4.21.4", "protein_names_refseq": "CG18681-PA; epsilonTry-PA; epsilonTrypsin", "tax_id": 7227, "disease": "amelogenesis imperfecta type 2A1 (Disease Ontology:DOID:0110057); prostate cancer (Disease Ontology:DOID:10283); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394)", "pathway": " (dme:Dmel_CG18681)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10486967;10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6IDF4;Q9V5Y1", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0017171 serine hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P35005-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35820-1", "uniprot_id": [ { "id": "PSC_DROME", "url": "https://www.uniprot.org/uniprot/P35820", "type": "external" } ], "mass": 169833.0, "length": 1601, "protein_name": "Polycomb group protein Psc", "gene_name": "Psc", "organism": "Fruit fly", "refseq_name": "posterior sex combs, isoform B", "refseq_ac": [ { "id": "NP_001286368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286368", "type": "external" } ], "gene_names_uniprotkb": "Psc; CG3886", "gene_names_refseq": "49Ea; CG3886; D-Bmi; Dmel\\CG3886; PSC; Psc1; Psc; Su(z)2-C; Suz2; dPSC; l(2)49Ea; l(2)Psc; l(2)vr14; psc; vr14", "protein_names_uniprotkb": "Polycomb group protein Psc; Protein posterior sex combs", "protein_names_refseq": "CG3886-PB; Psc-PB; posterior sex combs, isoform B; posterior sex combs; posterior-sex-combs", "tax_id": 7227, "disease": "chronic pancreatitis (Disease Ontology:DOID:0051065); colorectal carcinoma (Disease Ontology:DOID:0080199); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); renal Wilms' tumor (Disease Ontology:DOID:5176); hepatocellular carcinoma (Disease Ontology:DOID:684); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (dme:Dmel_CG3886)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;11493925;11583617;12537572;16024794;18327897;1833647", "class_list": "", "function": "Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and Bithorax (BX-C) complexes, and hence for the maintenance of segmental determination., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9V6I9", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0043565 sequence-specific DNA binding;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0031519 PcG protein complex;GO:0035102 PRC1 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P35820-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37159-1", "uniprot_id": [ { "id": "LYSE_DROME", "url": "https://www.uniprot.org/uniprot/P37159", "type": "external" } ], "mass": 15553.0, "length": 140, "protein_name": "Lysozyme E", "gene_name": "LysE", "organism": "Fruit fly", "refseq_name": "lysozyme E", "refseq_ac": [ { "id": "NP_476827", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476827", "type": "external" } ], "gene_names_uniprotkb": "LysE; CG1180", "gene_names_refseq": "BcDNA:LP07339; CG1180; Dmel\\CG1180; Lys E; LysE; lysE", "protein_names_uniprotkb": "Lysozyme E; 1,4-beta-N-acetylmuramidase E; 3.2.1.17", "protein_names_refseq": "CG1180-PA; LysE-PA; lysozyme E", "tax_id": 7227, "disease": "gastroenteritis (Disease Ontology:DOID:2326)", "pathway": " (dme:Dmel_CG1180); (R-DME-6798695); (R-DME-6803157)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10731132;12537572;8159165", "class_list": "glycogene;glycosylhydrolase", "function": "Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C9QP86;Q8MS67;Q9W0J5", "ec_number_list": [ { "id": "3.5.2.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.17", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.5.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.28", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.4.17.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.13", "type": "external" }, { "id": "1.11.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.-", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0031640 killing of cells of another organism;GO:0045824 negative regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P37159-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37160-1", "uniprot_id": [ { "id": "LYSS_DROME", "url": "https://www.uniprot.org/uniprot/P37160", "type": "external" } ], "mass": 15652.0, "length": 140, "protein_name": "Lysozyme S", "gene_name": "LysS", "organism": "Fruit fly", "refseq_name": "lysozyme S", "refseq_ac": [ { "id": "NP_476829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476829", "type": "external" } ], "gene_names_uniprotkb": "LysS; CG1165", "gene_names_refseq": "BcDNA:LP06719; CG1165; Dmel\\CG1165; LysS; lysS", "protein_names_uniprotkb": "Lysozyme S; 1,4-beta-N-acetylmuramidase S; 3.2.1.17", "protein_names_refseq": "CG1165-PA; LysS-PA; lysozyme S", "tax_id": 7227, "disease": "gastroenteritis (Disease Ontology:DOID:2326)", "pathway": " (dme:Dmel_CG1165); (R-DME-6798695); (R-DME-6803157)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;8159165", "class_list": "glycogene;glycosylhydrolase", "function": "Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W0J3", "ec_number_list": [ { "id": "3.5.2.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.17", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.5.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.28", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.4.17.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.13", "type": "external" }, { "id": "1.11.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.-", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P37160-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37161-1", "uniprot_id": [ { "id": "LYSX_DROME", "url": "https://www.uniprot.org/uniprot/P37161", "type": "external" } ], "mass": 15591.0, "length": 142, "protein_name": "Lysozyme X", "gene_name": "LysX", "organism": "Fruit fly", "refseq_name": "lysozyme X", "refseq_ac": [ { "id": "NP_523881", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523881", "type": "external" } ], "gene_names_uniprotkb": "LysX; CG9120", "gene_names_refseq": "BcDNA:LP09906; CG9120; Dmel\\CG9120; LysX; lysX", "protein_names_uniprotkb": "Lysozyme X; 1,4-beta-N-acetylmuramidase X; 3.2.1.17", "protein_names_refseq": "CG9120-PA; LysX-PA; lysozyme X", "tax_id": 7227, "disease": "gastroenteritis (Disease Ontology:DOID:2326)", "pathway": " (dme:Dmel_CG9120); (R-DME-6798695); (R-DME-6803157)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;17465907;8159165", "class_list": "glycogene;glycosylhydrolase", "function": "Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food. May be involved in the clearance of bacteria from the larval gut before metamorphosis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V9W9;A4V9X0;A4V9X1;A4V9X2;Q9W0K1", "ec_number_list": [ { "id": "3.5.2.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.17", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.5.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.28", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.4.17.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.13", "type": "external" }, { "id": "1.11.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.-", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P37161-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40141-1", "uniprot_id": [ { "id": "NG4_DROME", "url": "https://www.uniprot.org/uniprot/P40141", "type": "external" } ], "mass": 7100.0, "length": 57, "protein_name": "Protein new-glue 4", "gene_name": "ng4", "organism": "Fruit fly", "refseq_name": "new glue 4", "refseq_ac": [ { "id": "NP_476944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476944", "type": "external" } ], "gene_names_uniprotkb": "ng4; CG10789", "gene_names_refseq": "CG10789; Dmel\\CG10789; EG:96G10.2; ng-4; ng4; ng", "protein_names_uniprotkb": "Protein new-glue 4; NG-4", "protein_names_refseq": "CG10789-PA; new glue 4; ng4-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10789)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;10731137;12537572;8510164", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W4T5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P40141-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40304-1", "uniprot_id": [ { "id": "PSB1_DROME", "url": "https://www.uniprot.org/uniprot/P40304", "type": "external" } ], "mass": 25842.0, "length": 235, "protein_name": "Proteasome subunit beta type-1", "gene_name": "Prosbeta6", "organism": "Fruit fly", "refseq_name": "proteasome beta6 subunit", "refseq_ac": [ { "id": "NP_524115", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524115", "type": "external" } ], "gene_names_uniprotkb": "Prosbeta6; CG4097; PROS-26; Pros26; l(3)73Ai", "gene_names_refseq": "Beta-6; CG4097; DTS-5; DTS5; Dmel\\CG4097; PSB1_DROME; PSMB1; Pros26-DTS; Pros26; Prosbeta6; b6; beta-6; beta6_dm; beta6; l(3)73Ai; l(3)DTS-5; l(3)DTS5; pros26B; pros26beta6; pros26; prosbeta6", "protein_names_uniprotkb": "Proteasome subunit beta type-1; Proteasome 26 kDa subunit", "protein_names_refseq": "20S proteasome; CG4097-PA; Prosbeta6-PA; beta6 proteosome subunit; beta6; proteasome 26kD subunit; proteasome beta6 subunit; proteasome beta6; proteasome subunit 20S", "tax_id": 7227, "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); intellectual disability (Disease Ontology:DOID:1059); microcephaly (Disease Ontology:DOID:10907); neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dme:Dmel_CG4097); (R-DME-209360); (R-DME-209406); (R-DME-209461); (R-DME-216167); (R-DME-432395); (R-DME-432524); (R-DME-432626); (R-DME-538864)", "pathway_count": 9, "publication_count": 36, "publication_id_list": "10102270;10417378;10458606;10481010;10731132;11585911;12231619;12432393;12442174;12537569;12537572;12973300;15178801;15258584;15331761;16139204;16299518;16326393;16386907;16543224;16603629;16651542;16740475;16794082;17102630;17925225;18519643;18593878;19185492;7705656;8415617;8948598;9025065;9215627;9553105;9990853", "class_list": "", "function": "Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VV84", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000502 proteasome complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0010498 proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 3.7, "record_id": "P40304-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40796-1", "uniprot_id": [ { "id": "LA_DROME", "url": "https://www.uniprot.org/uniprot/P40796", "type": "external" } ], "mass": 44885.0, "length": 390, "protein_name": "La protein homolog", "gene_name": "La", "organism": "Fruit fly", "refseq_name": "La autoantigen-like", "refseq_ac": [ { "id": "NP_477014", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477014", "type": "external" } ], "gene_names_uniprotkb": "La; CG10922", "gene_names_refseq": "38C.38; BEST:LD24519; CG10922; D-La; DLa/SS-B; Dmel\\CG10922; La; dmLa", "protein_names_uniprotkb": "La protein homolog; La autoantigen homolog; La ribonucleoprotein", "protein_names_refseq": "CG10922-PA; La autoantigen-like; La-PA; ribonucleoprotein La", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10922)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;17372656;8035794;8035818", "class_list": "", "function": "May be involved in transcription termination by RNA polymerase III. Binds RNA and DNA. Binds to precursors of RNA polymerase III transcripts. May play a specialized role during fly development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24375;Q9VIN2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0008098 5S rRNA primary transcript binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000791 euchromatin;GO:0010494 cytoplasmic stress granule;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0008033 tRNA processing;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P40796-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41374-1", "uniprot_id": [ { "id": "IF2A_DROME", "url": "https://www.uniprot.org/uniprot/P41374", "type": "external" } ], "mass": 38646.0, "length": 341, "protein_name": "Eukaryotic translation initiation factor 2 subunit 1", "gene_name": "eIF2alpha", "organism": "Fruit fly", "refseq_name": "eukaryotic translation initiation factor 2 subunit alpha, isoform B", "refseq_ac": [ { "id": "NP_001285329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285329", "type": "external" } ], "gene_names_uniprotkb": "eIF2alpha; CG9946; Dmel\\CG9946; Dmel_CG9946; EIF-2alpha; EIF2alpha; Eif2alpha; Elf; IF2A_DROME; M(1)14C; M(1)19-153; M(1)8e3-10; P-eIF2alpha; deIF2alpha; eIF-2 alpha; eIF-2 a; eIF-2alphaeIF-2alpha; eIF-2alpha; eIF-2; eIF2 alpha; eIF2-alpha; eIF2a; eiF-2alpha; elF2alpha; l(1)14Cf; l(1)19-153", "gene_names_refseq": "CG9946; Dmel\\CG9946; EIF-2alpha; EIF2alpha; Eif2alpha; Elf; IF2A_DROME; M(1)14C; M(1)19-153; M(1)8e3-10; P-eIF2alpha; deIF2alpha; eIF-2 alpha; eIF-2 a; eIF-2alphaeIF-2alpha; eIF-2alpha; eIF-2; eIF2 alpha; eIF2-alpha; eIF2alpha; eIF2a; eiF-2alpha; elF2alpha; l(1)14Cf; l(1)19-153", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha; eIF2-alpha", "protein_names_refseq": "CG9946-PB; eIF-2alpha; eIF2alpha-PB; eukaryotic initiation factor 2alpha; eukaryotic translation initiation factor 2 subunit alpha, isoform B; eukaryotic translation initiation factor 2alpha; eukaryotic translation initiation factor 2; minute (1) 14C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9946); (R-DME-156827); (R-DME-381042); (R-DME-382556); (R-DME-72649); (R-DME-72695); (R-DME-72702); (R-DME-72731); (R-DME-9840373)", "pathway_count": 9, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;12605680;16110336;17569856;17569867;25589440;26109356;26109357;8144032", "class_list": "", "function": "eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This pre-initiation complex mediates ribosomal recognition of a start codon during the scanning process of the leader region., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V3G2", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0043022 ribosome binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0033290 eukaryotic 48S preinitiation complex;GO:0005851 eukaryotic translation initiation factor 2B complex;GO:0005850 eukaryotic translation initiation factor 2 complex", "go_biological_process": "GO:0006413 translational initiation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P41374-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42279-1", "uniprot_id": [ { "id": "TRYU_DROME", "url": "https://www.uniprot.org/uniprot/P42279", "type": "external" } ], "mass": 28088.0, "length": 262, "protein_name": "Trypsin eta", "gene_name": "etaTry", "organism": "Fruit fly", "refseq_name": "etaTrypsin", "refseq_ac": [ { "id": "NP_523692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523692", "type": "external" } ], "gene_names_uniprotkb": "etaTry; CG12386", "gene_names_refseq": "169C4S; CG12386; DmEtaTry; Dmel\\CG12386; ESTS:169C4S; EtaTry; SP57; anon-sts17; etaTry", "protein_names_uniprotkb": "Trypsin eta; 3.4.21.4", "protein_names_refseq": "CG12386-PA; etaTry-PA; etaTrypsin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12386)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10486967;10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NLM5;Q9V5X9", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0017171 serine hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P42279-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42280-1", "uniprot_id": [ { "id": "TRYZ_DROME", "url": "https://www.uniprot.org/uniprot/P42280", "type": "external" } ], "mass": 29738.0, "length": 280, "protein_name": "Trypsin zeta", "gene_name": "zetaTry", "organism": "Fruit fly", "refseq_name": "zetaTrypsin", "refseq_ac": [ { "id": "NP_523691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523691", "type": "external" } ], "gene_names_uniprotkb": "zetaTry; CG12387", "gene_names_refseq": "CG12387; DmZetaTry; Dmel\\CG12387; SP110; ZetaTry; zetaTryp; zetaTry", "protein_names_uniprotkb": "Trypsin zeta; 3.4.21.4", "protein_names_refseq": "CG12387-PA; zetaTry-PA; zetaTrypsin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12387)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10486967;10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V5X8", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0017171 serine hydrolase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P42280-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47949-1", "uniprot_id": [ { "id": "TNNC3_DROME", "url": "https://www.uniprot.org/uniprot/P47949", "type": "external" } ], "mass": 17696.0, "length": 155, "protein_name": "Troponin C, isoform 3", "gene_name": "TpnC73F", "organism": "Fruit fly", "refseq_name": "troponin C at 73F, isoform C", "refseq_ac": [ { "id": "NP_001287091", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287091", "type": "external" } ], "gene_names_uniprotkb": "TpnC73F; CG7930; DmTnC3; DmTpnC73F; DmTpnCIa; Dmel\\CG7930; Dmel_CG7930; TNC73F; TNC; TnC73F; TnC; Tnc2; TpnC Ia; TpnCIa; tpnC73F", "gene_names_refseq": "CG7930; DmTnC3; DmTpnC73F; DmTpnCIa; Dmel\\CG7930; TNC73F; TNC; TnC73F; TnC; Tnc2; TpnC Ia; TpnC73F; TpnCIa; tpnC73F", "protein_names_uniprotkb": "Troponin C, isoform 3", "protein_names_refseq": "CG7930-PC; TpnC73F-PC; TroponinC73F; troponin C at 73F, isoform C; troponin C73F", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7930); (R-DME-111932); (R-DME-111933); (R-DME-111957); (R-DME-114608); (R-DME-1474151); (R-DME-163615); (R-DME-1855204); (R-DME-2025928); (R-DME-203615); (R-DME-2514859); (R-DME-2871809); (R-DME-4086398); (R-DME-418359); (R-DME-425561); (R-DME-438066); (R-DME-442729); (R-DME-451308); (R-DME-5218920); (R-DME-5578775); (R-DME-5607763); (R-DME-5673000); (R-DME-70221); (R-DME-8876725); (R-DME-9009391); (R-DME-936837); (R-DME-9619229); (R-DME-9648002); (R-DME-9856530)", "pathway_count": 29, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;7980384", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C8VV65;Q9VVE1", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P47949-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48375-1", "uniprot_id": [ { "id": "FKB12_DROME", "url": "https://www.uniprot.org/uniprot/P48375", "type": "external" } ], "mass": 11666.0, "length": 108, "protein_name": "Peptidyl-prolyl cis-trans isomerase Fkbp12", "gene_name": "Fkbp12", "organism": "Fruit fly", "refseq_name": "FK506-binding protein 12kD", "refseq_ac": [ { "id": "NP_523792", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523792", "type": "external" } ], "gene_names_uniprotkb": "Fkbp12; CG11001; FK506-bp2", "gene_names_refseq": "11001; 143729_at; CG11001; Dmel\\CG11001; DrFKBP12; FK506-BP2; FK506-bp2; FKBP12; FKBP; Fk506-bp2; Fkbp12; dFKBP12; fkbp", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase Fkbp12; 12 kDa FK506-binding protein; 12 kDa FKBP; 5.2.1.8; Macrolide-binding protein; PPIase Fkbp12; PPIase; Peptidyl-prolyl cis-trans isomerase; Rotamase", "protein_names_refseq": "CG11001-PA; DmFKBP12; FK506-binding protein 12kD; FK506-binding protein 2; FK506-binding protein; Fkbp12-PA; calstabin", "tax_id": 7227, "disease": "Barth syndrome (Disease Ontology:DOID:0050476); cardiomyopathy (Disease Ontology:DOID:0050700); catecholaminergic polymorphic ventricular tachycardia (Disease Ontology:DOID:0060674); Parkinsonism (Disease Ontology:DOID:0080855); Graves' disease (Disease Ontology:DOID:12361); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (dme:Dmel_CG11001); (R-DME-166208); (R-DME-2025928); (R-DME-2173789)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;8756725", "class_list": "", "function": "PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Binds to ligand-free TGF beta type I receptor, from which it is released upon a ligand-induced, type II receptor mediated phosphorylation of the type I receptor. Binding is inhibitory to the signaling pathways of the TGF beta family ligands., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SZ56;Q9V8S8", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0034713 type I transforming growth factor beta receptor binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "GO:0006457 protein folding;GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P48375-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48555-1", "uniprot_id": [ { "id": "RALA_DROME", "url": "https://www.uniprot.org/uniprot/P48555", "type": "external" } ], "mass": 22938.0, "length": 201, "protein_name": "Ras-related protein Ral-a", "gene_name": "Rala", "organism": "Fruit fly", "refseq_name": "Ras-like protein A, isoform C", "refseq_ac": [ { "id": "NP_525063", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525063", "type": "external" } ], "gene_names_uniprotkb": "Rala; CG2849", "gene_names_refseq": "24639550; CG2849; D-RalA; DRala; DRal; Dm RalA; Dmel\\CG2849; DralA; Drala; Dral; P48555; RALA; Ral-a; RalA; Rala; Ral; anon-EST:fe1H4; dRal; l(1)G0174; l(1)G0373; l(1)G0501; ralA; rala; ral", "protein_names_uniprotkb": "Ras-related protein Ral-a; 3.6.5.2", "protein_names_refseq": "CG2849-PC; Rala-PC; Ras-like protein A, isoform C; Ras-like protein A; Ras-related protein; anon-fast-evolving-1H4", "tax_id": 7227, "disease": "pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); pancreatic adenocarcinoma (Disease Ontology:DOID:4074)", "pathway": " (dme:Dmel_CG2849)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q540X1;Q9W4Q6", "ec_number_list": [ { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0030165 PDZ domain binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032154 cleavage furrow;GO:0090543 Flemming body", "go_biological_process": "GO:2000648 positive regulation of stem cell proliferation;GO:0031623 receptor internalization;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P48555-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48604-1", "uniprot_id": [ { "id": "GRPE_DROME", "url": "https://www.uniprot.org/uniprot/P48604", "type": "external" } ], "mass": 23926.0, "length": 213, "protein_name": "GrpE protein homolog, mitochondrial", "gene_name": "Roe1", "organism": "Fruit fly", "refseq_name": "Roe1", "refseq_ac": [ { "id": "NP_610886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610886", "type": "external" } ], "gene_names_uniprotkb": "Roe1; CG6155", "gene_names_refseq": "BcDNA:GM03203; CG6155; DROE1; Dmel\\CG6155; Droe1; Roe1; Roe; cg6155; droe1", "protein_names_uniprotkb": "GrpE protein homolog, mitochondrial; dRoe1", "protein_names_refseq": "CG6155-PA; Roe1-PA; Roe1", "tax_id": 7227, "disease": "middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (dme:Dmel_CG6155)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SX27;Q9V6R8", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0001405 PAM complex, Tim23 associated import motor", "go_biological_process": "GO:0042026 protein refolding;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P48604-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48613-1", "uniprot_id": [ { "id": "TIPE_DROME", "url": "https://www.uniprot.org/uniprot/P48613", "type": "external" } ], "mass": 50190.0, "length": 452, "protein_name": "Protein tipE", "gene_name": "tipE", "organism": "Fruit fly", "refseq_name": "temperature-induced paralytic E, isoform A", "refseq_ac": [ { "id": "NP_523920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523920", "type": "external" } ], "gene_names_uniprotkb": "tipE; CG1232", "gene_names_refseq": "CG1232; Dmel\\CG1232; TipE; tip-E; tipE", "protein_names_uniprotkb": "Protein tipE; Temperature-induced paralytic E", "protein_names_refseq": "CG1232-PA; temperature-induced paralysis locus E; temperature-induced paralysis, locus E; temperature-induced paralytic E, isoform A; temperature-induced-paralytic-E; tipE-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1232)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;7553842", "class_list": "", "function": "Enhances para sodium channel function. Required during pupal development to rescue adult paralysis and also protects adult flies against heat-induced lethality., [UniProtKB, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A4V1G4;Q9VZG6", "ec_number_list": [], "go_molecular_function": "GO:0017080 sodium channel regulator activity;GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0034605 cellular response to heat;GO:0002028 regulation of sodium ion transport;GO:0006814 sodium ion transport;GO:0045433 male courtship behavior, veined wing generated song production", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P48613-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48994-1", "uniprot_id": [ { "id": "TRPL_DROME", "url": "https://www.uniprot.org/uniprot/P48994", "type": "external" } ], "mass": 127750.0, "length": 1124, "protein_name": "Transient-receptor-potential-like protein", "gene_name": "trpl", "organism": "Fruit fly", "refseq_name": "transient receptor potential-like, isoform A", "refseq_ac": [ { "id": "NP_476895", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476895", "type": "external" } ], "gene_names_uniprotkb": "trpl; CG18345", "gene_names_refseq": "CG1694; CG18345; DmTRPL; Dmel\\CG18345; TRP-Like; TRPL; TrpL; Trpl; dTRPL; dTrpL; trp-l; trpL; trpl", "protein_names_uniprotkb": "Transient-receptor-potential-like protein", "protein_names_refseq": "CG18345-PA; TRP-like; transient receptor Potential-Like; transient receptor potential-like, isoform A; trpl-PA", "tax_id": 7227, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); lung cancer (Disease Ontology:DOID:1324)", "pathway": " (dme:Dmel_CG18345); (R-DME-3295583); (R-DME-5578775); (R-DME-983695)", "pathway_count": 4, "publication_count": 15, "publication_id_list": "10371201;10731132;10896160;10908615;11514552;11707492;11931743;12537569;12537572;1314616;8670063;8918461;9215637;9494079;9930700", "class_list": "", "function": "A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Required for vision in the dark and in dim light. Binds calmodulin. Trp and trpl act together in the light response, although it is unclear whether as heteromultimers or distinct units. Also forms a functional cation channel with Trpgamma. Activated by fatty acids, metabolic stress, inositols and GTP-binding proteins., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "C6TPC1;Q0E9E3;Q8IH62;Q8MKU9;Q9V5B2", "ec_number_list": [], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0016028 rhabdomere", "go_biological_process": "GO:0071454 cellular response to anoxia;GO:0006811 monoatomic ion transport;GO:0019722 calcium-mediated signaling;GO:0006816 calcium ion transport;GO:0051480 regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P48994-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49283-2", "uniprot_id": [ { "id": "MVL_DROME", "url": "https://www.uniprot.org/uniprot/P49283", "type": "external" } ], "mass": 65466.0, "length": 596, "protein_name": "Protein Malvolio", "gene_name": "Mvl", "organism": "Fruit fly", "refseq_name": "malvolio, isoform D", "refseq_ac": [ { "id": "NP_001163668", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163668", "type": "external" } ], "gene_names_uniprotkb": "Mvl; CG3671", "gene_names_refseq": "CG3671; DMT1; Dmel\\CG3671; Mvl; NRM2; dNRAMP; mvl", "protein_names_uniprotkb": "Protein Malvolio", "protein_names_refseq": "/Divalent metal transporter; CG3671-PD; Mvl-PD; malvolio, isoform D; malvolio", "tax_id": 7227, "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); Buruli ulcer disease (Disease Ontology:DOID:0050456); inflammatory bowel disease (Disease Ontology:DOID:0050589); lymphoproliferative syndrome (Disease Ontology:DOID:0060704); Parkinsonism (Disease Ontology:DOID:0080855); leprosy (Disease Ontology:DOID:1024); urinary bladder cancer (Disease Ontology:DOID:11054); sarcoidosis (Disease Ontology:DOID:11335); iron deficiency anemia (Disease Ontology:DOID:11758); hypochromic anemia (Disease Ontology:DOID:11759); Behcet's disease (Disease Ontology:DOID:13241); Parkinson's disease (Disease Ontology:DOID:14330); duodenal ulcer (Disease Ontology:DOID:1724); brain ischemia (Disease Ontology:DOID:2316); anemia (Disease Ontology:DOID:2355); multiple sclerosis (Disease Ontology:DOID:2377); pulmonary tuberculosis (Disease Ontology:DOID:2957); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); tuberculosis (Disease Ontology:DOID:399); systemic scleroderma (Disease Ontology:DOID:418); pneumonia (Disease Ontology:DOID:552); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); rheumatoid arthritis (Disease Ontology:DOID:7148); gastrointestinal system disease (Disease Ontology:DOID:77); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); systemic lupus erythematosus (Disease Ontology:DOID:9074); cutaneous leishmaniasis (Disease Ontology:DOID:9111); visceral leishmaniasis (Disease Ontology:DOID:9146); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dme:Dmel_CG3671); (R-DME-1222556); (R-DME-425410); (R-DME-6798695); (R-DME-6803544); (R-DME-917937)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;7621816", "class_list": "", "function": "Putative transporter required for normal taste behavior. May be a nitrite/nitrate transporter., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 30, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q95TT7;Q9VDF5", "ec_number_list": [], "go_molecular_function": "GO:0015293 symporter activity;GO:0005375 copper ion transmembrane transporter activity;GO:0005384 manganese ion transmembrane transporter activity;GO:0005381 iron ion transmembrane transporter activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0034755 iron ion transmembrane transport;GO:0006879 intracellular iron ion homeostasis;GO:0046718 symbiont entry into host cell;GO:0015677 copper ion import;GO:0030001 metal ion transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P49283-2", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49657-1", "uniprot_id": [ { "id": "MNB_DROME", "url": "https://www.uniprot.org/uniprot/P49657", "type": "external" } ], "mass": 95903.0, "length": 908, "protein_name": "Serine/threonine-protein kinase minibrain", "gene_name": "mnb", "organism": "Fruit fly", "refseq_name": "minibrain, isoform G", "refseq_ac": [ { "id": "NP_001014750", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014750", "type": "external" } ], "gene_names_uniprotkb": "mnb; CG42273; CG7826; CG7835; DYRK1A; DYRK1; Dm1; DmDyrk1A; Dmel\\CG42273; Dmel_CG42273; Dyrk1A; Dyrk1a; Dyrk1; ME-IV; MNB; Minibrain; Mnb; min", "gene_names_refseq": "CG42273; CG7826; CG7835; DYRK1A; DYRK1; Dm1; DmDyrk1A; Dmel\\CG42273; Dyrk1A; Dyrk1a; Dyrk1; ME-IV; MNB; Minibrain; Mnb; min; mnb", "protein_names_uniprotkb": "Serine/threonine-protein kinase minibrain; 2.7.12.1", "protein_names_refseq": "CG42273-PG; Dual-specificity tyrosine phosphorylation-regulated kinase 1A; minibrain kinase; minibrain, isoform G; minibrain; mnb-PG", "tax_id": 7227, "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); autism spectrum disorder (Disease Ontology:DOID:0060041); abdominal obesity-metabolic syndrome 3 (Disease Ontology:DOID:0060612); autosomal dominant intellectual developmental disorder 7 (Disease Ontology:DOID:0070037); intellectual disability (Disease Ontology:DOID:1059); dilated cardiomyopathy (Disease Ontology:DOID:12930); Down syndrome (Disease Ontology:DOID:14250); renovascular hypertension (Disease Ontology:DOID:1591); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); hyperhomocysteinemia (Disease Ontology:DOID:9279)", "pathway": " (dme:Dmel_CG42273); (R-DME-1538133)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;33925313;7857639", "class_list": "", "function": "Role in the specific control of proper proliferation of optic lobe neuronal progeny., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 11, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q59E39;Q6AWJ3;Q9I7R8;Q9VX07", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0004674 protein serine/threonine kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004712 protein serine/threonine/tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0043195 terminal bouton", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:1900244 positive regulation of synaptic vesicle endocytosis;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045666 positive regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P49657-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49906-1", "uniprot_id": [ { "id": "TAF11_DROME", "url": "https://www.uniprot.org/uniprot/P49906", "type": "external" } ], "mass": 22091.0, "length": 196, "protein_name": "Transcription initiation factor TFIID subunit 11", "gene_name": "Taf11", "organism": "Fruit fly", "refseq_name": "TBP-associated factor 11", "refseq_ac": [ { "id": "NP_723484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_723484", "type": "external" } ], "gene_names_uniprotkb": "Taf11; CG4079; TAF30-BETA", "gene_names_refseq": "CG4079; Dmel\\CG4079; G3; TAF11; TAF1; TAF30beta; TAF30b; TAF[II]30beta; TAF[[II]]30beta; TAF[[II]]; TAF; TFIID 28 beta; TFIID-p28beta; TFIID; Taf11; Taf30beta; Taf[[II]]30beta; d30beta; dTAFII30 beta; dTAFII30beta; dTAFII30; dTAF[[II]]30beta; dTAF[[II]]30; taf11", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 11; TAFII30 beta; Transcription initiation factor TFIID 28 kDa subunit beta; p28-beta", "protein_names_refseq": "CG4079-PA; TBP-associated factor 11; TBP-associated factor 30kD subunit beta; Taf11-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4079); (R-DME-674695); (R-DME-6804756); (R-DME-6807505); (R-DME-73776); (R-DME-73779); (R-DME-75953); (R-DME-76042)", "pathway_count": 8, "publication_count": 5, "publication_id_list": "10731132;12537572;18327897;26257286;8276241", "class_list": "", "function": "The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity). Component of the short interfering RNAs (siRNAs)-directed RISC loading complex (siRLC) which acts in the dsRNA-mediated RNA interference (RNAi) pathway by siRNAs into the RNA-induced silencing complex (siRISC), the siRNA then serves as a guide to direct the siRISC to complementary endogenous or viral RNA transcripts for degradation or silencing (PubMed:26257286). Promotes formation of the siRLC by facilitating Dcr-2-R2D2 tetramerization to enhance siRNA binding and siRISC loading activities (PubMed:26257286)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VL90", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0051123 RNA polymerase II preinitiation complex assembly;GO:0022618 protein-RNA complex assembly;GO:0009616 RNAi-mediated antiviral immune response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P49906-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50536-1", "uniprot_id": [ { "id": "MSL3_DROME", "url": "https://www.uniprot.org/uniprot/P50536", "type": "external" } ], "mass": 58853.0, "length": 512, "protein_name": "Protein male-specific lethal-3", "gene_name": "msl-3", "organism": "Fruit fly", "refseq_name": "male-specific lethal 3", "refseq_ac": [ { "id": "NP_523951", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523951", "type": "external" } ], "gene_names_uniprotkb": "msl-3; CG8631", "gene_names_refseq": "CG8631; DmMsl-3; Dmel\\CG8631; MSL-3; MSL3_DROME; MSL3; MSL; Msl 1-3; Msl3; mle(3)132; mle3; mls3; msl-3; msl3; msl", "protein_names_uniprotkb": "Protein male-specific lethal-3", "protein_names_refseq": "CG8631-PA; gene 2; male sex lethal 3; male sex lethal-3; male specifc lethal; male specific lethal 3; male-specific lethal 3; males specific lethal 3; msl-3-PA", "tax_id": 7227, "disease": "Basilicata-Akhtar syndrome (Disease Ontology:DOID:0111838)", "pathway": " (dme:Dmel_CG8631); (R-DME-3214847)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10679323;10731132;11014199;12537569;12537572;16543150;17878295;17936709;18039888;18510926;19029895;20657587;23084834;32502394;34878097;7768187", "class_list": "", "function": "Component of the male-specific lethal (MSL) histone acetyltransferase complex, a multiprotein complex essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation) (PubMed:17936709, PubMed:19029895, PubMed:7768187). The MSL complex specifically associates with the single X chromosome in males and mediates formation of H4K16ac, promoting a two-fold activation of X chromosome (PubMed:16543150, PubMed:18510926). Acts as a histone reader that specifically recognizes and binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and histone H4 monomethylated at 'Lys-20' (H4K20me1) (PubMed:17936709, PubMed:19029895). Within the MSL complex, mediates the spreading of the MSL complex from initiation sites on the male X chromosome to flanking chromatin (PubMed:19029895). Following initial recruitment of the MSL complex to male X chromosome by msl-2, msl-3 binds H3K36me3 and promotes spreading of the MSL complex in cis (PubMed:19029895). In addition to its role in dosage compensation in males, promotes germline stem cell differentiation in females: recognizes and binds H3K36me3, promoting recruitment of the ATAC complex and transcription of genes, such as RpS19b (PubMed:34878097)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8BP72;A8BP74;A8BP87;A8BP92;A8IL14;A8IL17;A8IL22;A8IL25;A8IL30;A8IL33;A8IL37;A8IL41;A8IL46;Q8IQ74;Q9VS18", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0106222 lncRNA binding;GO:0140566 histone reader activity;GO:0140046 histone H4K16ac reader activity", "go_cellular_component": "GO:0035267 NuA4 histone acetyltransferase complex;GO:0000228 nuclear chromosome;GO:0072487 MSL complex;GO:0010369 chromocenter;GO:0000805 X chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0007281 germ cell development;GO:0048599 oocyte development", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "P50536-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52295-1", "uniprot_id": [ { "id": "IMA_DROME", "url": "https://www.uniprot.org/uniprot/P52295", "type": "external" } ], "mass": 57822.0, "length": 522, "protein_name": "Importin subunit alpha", "gene_name": "Pen", "organism": "Fruit fly", "refseq_name": "pendulin", "refseq_ac": [ { "id": "NP_477041", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477041", "type": "external" } ], "gene_names_uniprotkb": "Pen; CG4799", "gene_names_refseq": "2.1; CG4799; DPend; Dalpha2; Dimp-alpha2; Dmel\\CG4799; IMPalpha2; Imp alpha-2; Imp alpha2; Imp-alpha2; Impalpha2; Kap alpha2; Kap-alpha2; Kpna2; OHO31; Oho31; PEN; Pen; Rch1; alpha2A-Kap; alpha2; alphaKap2; anon-WO0140519.258; bs29g06.y1; imp alpha2; imp-alpha2; impalpha2; importin alpha2/pendulin; importin-alpha; l(2)144/1; l(2)k06324; l(2)k14401; mbmB[N806]; mbmB; mbm[B]; oho-31; oho31; pen-2; pen; rem", "protein_names_uniprotkb": "Importin subunit alpha; Karyopherin subunit alpha; Pendulin", "protein_names_refseq": "CG4799-PA; Importin-a2; Importin-alpha2; Importin-alpha; Pen-PA; alpha-importin; importin alpha2; importin alpha; lethal (2) k06324; mushroom body miniature B; mushroom-body-miniature-B; penduline; pendulin; reduced-mushroom-bodies", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4799); (R-DME-5693548)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;17372656;18327897;7790349;7790350", "class_list": "", "function": "Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity)., [UniProtKB]; It is required for normal cell proliferation and may serve as an adapter molecule to form complexes with other proteins. May act as a tumor suppressor in hematopoietic cells. May play a role in the nuclear import of karyophilic proteins and some of these may be required for the normal transmission and function of proliferative signals in the cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24431;Q95R96;Q9VL45", "ec_number_list": [], "go_molecular_function": "GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0042564 NLS-dependent protein nuclear import complex", "go_biological_process": "GO:0007291 sperm individualization;GO:0006607 NLS-bearing protein import into nucleus;GO:0007301 female germline ring canal formation;GO:0042332 gravitaxis;GO:0048542 lymph gland development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P52295-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52487-1", "uniprot_id": [ { "id": "UBC84_DROME", "url": "https://www.uniprot.org/uniprot/P52487", "type": "external" } ], "mass": 17746.0, "length": 153, "protein_name": "Ubiquitin-conjugating enzyme E2-18 kDa", "gene_name": "Ubc84D", "organism": "Fruit fly", "refseq_name": "ubiquitin conjugating enzyme 84D", "refseq_ac": [ { "id": "NP_524260", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524260", "type": "external" } ], "gene_names_uniprotkb": "Ubc84D; CG12799", "gene_names_refseq": "CG12799; Dmel\\CG12799; Ubc84D; UbcD84; ubc", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2-18 kDa; 2.3.2.23; E2 ubiquitin-conjugating enzyme 84D; Ubiquitin carrier protein; Ubiquitin-protein ligase", "protein_names_refseq": "CG12799-PA; Ubc84D-PA; ubiquitin conjugating enzyme 84D; ubiquitin conjugating enzyme", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12799); (R-DME-983168)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537572;8703090", "class_list": "", "function": "Catalyzes the covalent attachment of ubiquitin to other proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C4XVG9;Q9VIB4", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004842 ubiquitin-protein transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P52487-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54185-1", "uniprot_id": [ { "id": "OBA5_DROME", "url": "https://www.uniprot.org/uniprot/P54185", "type": "external" } ], "mass": 24573.0, "length": 210, "protein_name": "Putative odorant-binding protein A5", "gene_name": "a5", "organism": "Fruit fly", "refseq_name": "antennal protein 5", "refseq_ac": [ { "id": "NP_476998", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476998", "type": "external" } ], "gene_names_uniprotkb": "a5; CG5430", "gene_names_refseq": "A5; CG5430; Dmel\\CG5430; a5", "protein_names_uniprotkb": "Putative odorant-binding protein A5; Antennal protein 5", "protein_names_refseq": "CG5430-PA; a5-PA; antennal protein 5", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5430); (R-DME-5674135); (R-DME-5675221)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10731132;12537572;7545907", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VPZ9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P54185-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54194-1", "uniprot_id": [ { "id": "OB84A_DROME", "url": "https://www.uniprot.org/uniprot/P54194", "type": "external" } ], "mass": 19513.0, "length": 175, "protein_name": "General odorant-binding protein 84a", "gene_name": "Obp84a", "organism": "Fruit fly", "refseq_name": "Odorant-binding protein 84a, isoform C", "refseq_ac": [ { "id": "NP_001097700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097700", "type": "external" } ], "gene_names_uniprotkb": "Obp84a; CG1176; Pbprp4", "gene_names_refseq": "84a; CG1176; DmelObp84a; Dmel\\CG1176; OBP84a; Obp84a; PBP4; PBPRP-4; PBPRP4; Pbprp4; pbprp-4; pbprp4", "protein_names_uniprotkb": "General odorant-binding protein 84a; Odorant-binding protein 84a; PBPRP-4; Pheromone-binding protein-related protein 4", "protein_names_refseq": "CG1176-PC; Obp84a-PC; Odorant-binding protein 84a, isoform C; Pbprp4; Pheromone-binding protein-related protein 4", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1176)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;7545907", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8JQU8;B3DN19;Q9VI86", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P54194-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54195-1", "uniprot_id": [ { "id": "OB28A_DROME", "url": "https://www.uniprot.org/uniprot/P54195", "type": "external" } ], "mass": 15152.0, "length": 143, "protein_name": "General odorant-binding protein 28a", "gene_name": "Obp28a", "organism": "Fruit fly", "refseq_name": "Odorant-binding protein 28a", "refseq_ac": [ { "id": "NP_523505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523505", "type": "external" } ], "gene_names_uniprotkb": "Obp28a; CG6641; Pbprp5", "gene_names_refseq": "28a; CG6641; DmelObp28a; Dmel\\CG6641; OBP28a; Obp28a; PB-PRP5; PBP5; PBPRP-5; PBPRP5; Pbprp5; obp28a; pbprp-5; pbprp5", "protein_names_uniprotkb": "General odorant-binding protein 28a; Odorant-binding protein 28a; PBPRP-5; Pheromone-binding protein-related protein 5", "protein_names_refseq": "CG6641-PA; Obp28a-PA; Odorant-binding protein 28a; Pbprp5; Pheromone-binding protein-related protein 5", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6641)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;7545907", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V3T8;Q9VM03", "ec_number_list": [], "go_molecular_function": "GO:0005550 pheromone binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007608 sensory perception of smell;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P54195-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54356-1", "uniprot_id": [ { "id": "TSG_DROME", "url": "https://www.uniprot.org/uniprot/P54356", "type": "external" } ], "mass": 27220.0, "length": 249, "protein_name": "Protein twisted gastrulation", "gene_name": "tsg", "organism": "Fruit fly", "refseq_name": "twisted gastrulation", "refseq_ac": [ { "id": "NP_511135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_511135", "type": "external" } ], "gene_names_uniprotkb": "tsg; CG1502", "gene_names_refseq": "CG1502; Dmel\\CG1502; RF32; Tsg; dTsg; l(1)11Ab; l(1)11Ac; l(1)RF32; l(1)tsg; tsg", "protein_names_uniprotkb": "Protein twisted gastrulation", "protein_names_refseq": "CG1502-PA; lethal(1)11Ac; tsg-PA; twisted gastrulation", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1502)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;11260716;12537572;7958834", "class_list": "", "function": "Involved in dorsal-ventral patterning. Required for specification of a narrow strip of dorsal midline cells that will give rise to the amnioserosa, but not for specification of dorsal ectoderm cells. Inhibits BMP signaling; enhances the binding of sog to dpp, thus enhancing the antagonistic activity of sog., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9VYR6", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0061133 endopeptidase activator activity;GO:0036122 BMP binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0030514 negative regulation of BMP signaling pathway;GO:0030510 regulation of BMP signaling pathway;GO:0007378 amnioserosa formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P54356-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54398-1", "uniprot_id": [ { "id": "FBP2_DROME", "url": "https://www.uniprot.org/uniprot/P54398", "type": "external" } ], "mass": 29014.0, "length": 256, "protein_name": "Fat body protein 2", "gene_name": "Fbp2", "organism": "Fruit fly", "refseq_name": "Fat body protein 2, isoform B", "refseq_ac": [ { "id": "NP_001285777", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285777", "type": "external" } ], "gene_names_uniprotkb": "Fbp2; CG3763", "gene_names_refseq": "CG3763; Dmel\\CG3763; FBP2; Fbp-2; Fbp2; P6; T19", "protein_names_uniprotkb": "Fat body protein 2; Fat body protein P6", "protein_names_refseq": "CG3763-PB; Fat body protein 2, isoform B; Fat body protein 2; Fbp2-PB; Protein-6; fat body protein P6", "tax_id": 7227, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); primary hypertrophic osteoarthropathy (Disease Ontology:DOID:14283); colon carcinoma (Disease Ontology:DOID:1520); carcinoma (Disease Ontology:DOID:305); prolactinoma (Disease Ontology:DOID:5394); growth hormone secreting pituitary adenoma (Disease Ontology:DOID:6255); pulmonary hypertension (Disease Ontology:DOID:6432); peptic ulcer disease (Disease Ontology:DOID:750)", "pathway": " (dme:Dmel_CG3763); (R-DME-2142700); (R-DME-9018676); (R-DME-9018896)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10331261;10731132;12537572;1920455", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O61511;O61512;O61513;O61514;O62595;Q9VLC2;X2J986", "ec_number_list": [], "go_molecular_function": "GO:0004022 alcohol dehydrogenase (NAD+) activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0045735 nutrient reservoir activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0097009 energy homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P54398-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55162-1", "uniprot_id": [ { "id": "HEM_DROME", "url": "https://www.uniprot.org/uniprot/P55162", "type": "external" } ], "mass": 129380.0, "length": 1126, "protein_name": "Membrane-associated protein Hem", "gene_name": "Hem", "organism": "Fruit fly", "refseq_name": "HEM-protein", "refseq_ac": [ { "id": "NP_524214", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524214", "type": "external" } ], "gene_names_uniprotkb": "Hem; 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CG30030", "gene_names_refseq": "47F.1; CG30030; Dmel\\CG30030; GR47F.1; GR47b; Gr47F1; Gr47b", "protein_names_uniprotkb": "Putative gustatory receptor 47b", "protein_names_refseq": "CG30030-PA; Gr47b-PA; gustatory receptor 47F.1; gustatory receptor 47b", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG30030)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;22031876", "class_list": "", "function": "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MKZ0", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0008527 taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0008049 male courtship behavior;GO:0007165 signal transduction;GO:0034220 monoatomic ion transmembrane transport;GO:0007635 chemosensory behavior;GO:0050909 sensory perception of taste", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P58961-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58962-1", "uniprot_id": [ { "id": "GR58A_DROME", "url": "https://www.uniprot.org/uniprot/P58962", "type": "external" } ], "mass": 46262.0, "length": 395, "protein_name": "Putative gustatory receptor 58a", "gene_name": "Gr58a", "organism": "Fruit fly", "refseq_name": "gustatory receptor 58a", "refseq_ac": [ { "id": "NP_726135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_726135", "type": "external" } ], "gene_names_uniprotkb": "Gr58a; 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CG9359; TubB85D", "gene_names_refseq": "2t; B2t; BETA 85D; BETA2; BetaTub85D; Betatub85D; CG9359; D.m.BETA-85D; DTB4; Dmbeta2; Dmel\\CG9359; FBgn0003889; TUBB2A; Tub2A; Tub85D; Tub; beta(2)Tub; beta(2)Tu; beta-Tub85D; beta-tub85D; beta-tub; beta2-tub; beta2tub; beta2t; beta2; beta85D; betaTub2; betaTub85D; betaTub; beta[[2]]-tubulin; betatub85D; betatubulin; beta; ms(3)KK[D]", "protein_names_uniprotkb": "Tubulin beta-2 chain; Beta-2-tubulin", "protein_names_refseq": "CG9359-PA; b2 tubulin; beta 2 tubulin; beta tubulin; beta(2)Tubulin; beta-Tubulin 85D; beta-Tubulin at 85D; beta-tubulin85D; beta2 tubulin; beta2-tubulin; beta2tubulin; betaTub85D-PA; betaTubulin85D; testis-specific beta-tubulin", "tax_id": 7227, "disease": "cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome (Disease Ontology:DOID:0050997); ptosis (Disease Ontology:DOID:0060260); complex cortical dysplasia with other brain malformations 7 (Disease Ontology:DOID:0090132); complex cortical dysplasia with other brain malformations 5 (Disease Ontology:DOID:0090135); tubulinopathy (Disease Ontology:DOID:0112227); facial paralysis (Disease Ontology:DOID:13934); hypokalemic periodic paralysis (Disease Ontology:DOID:14452)", "pathway": " (dme:Dmel_CG9359); (R-DME-3371497); (R-DME-6807878); (R-DME-6811436)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;3119300;8500545", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P08840;P22247;Q540X8;Q9VHE1", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization;GO:0007435 salivary gland morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P61857-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81900-1", "uniprot_id": [ { "id": "KAPR2_DROME", "url": "https://www.uniprot.org/uniprot/P81900", "type": "external" } ], "mass": 42748.0, "length": 377, "protein_name": "cAMP-dependent protein kinase type II regulatory subunit", "gene_name": "Pka-R2", "organism": "Fruit fly", "refseq_name": "protein kinase, cAMP-dependent, regulatory subunit type 2, isoform D", "refseq_ac": [ { "id": "NP_001097251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097251", "type": "external" } ], "gene_names_uniprotkb": "Pka-R2; CG15862; pka-RII", "gene_names_refseq": "BcDNA:GM01761; CG15862; Cos-1; Cos1; Cos; Dmel\\CG15862; Epa; PKA R2; PKA RII; PKA-R2; PKA-RII; PKAR2; PKA; PKa-R2; Pka-R2; Pka-RII; RII[[DR]]; RII; cos1; pkA; pka RII; pka-RII", "protein_names_uniprotkb": "cAMP-dependent protein kinase type II regulatory subunit", "protein_names_refseq": "CG15862-PD; Costal-1; Pka-R2-PD; cAMP-dependent protein kinase R2; cAMP-dependent protein kinase type II; costal; epaulette; protein kinase A; protein kinase, cAMP-dependent, regulatory subunit type 2, isoform D", "tax_id": 7227, "disease": "granulosa cell tumor (Disease Ontology:DOID:2999); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (dme:Dmel_CG15862); (R-DME-163615); (R-DME-164378); (R-DME-180024); (R-DME-432040); (R-DME-442720); (R-DME-5610787); (R-DME-9634597); (R-DME-983231); (R-DME-9856530)", "pathway_count": 10, "publication_count": 9, "publication_id_list": "10480936;10731132;10781603;12223401;12537569;12537572;18327897;29444420;9196067", "class_list": "", "function": "Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells (PubMed:10781603, PubMed:9196067). Mediates membrane association by binding to anchoring proteins, such as Akap200 (PubMed:12223401, PubMed:9196067). Might play an essential role in the regulation of neuronal activity in the brain (PubMed:10781603, PubMed:9196067)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1A6P8;A1A6T9;A2RVH2;A4UZA6;A8DY87;A8DY88;Q9NB18;Q9V5E8", "ec_number_list": [], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005952 cAMP-dependent protein kinase complex", "go_biological_process": "GO:0042048 olfactory behavior;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0048149 behavioral response to ethanol;GO:0071361 cellular response to ethanol;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P81900-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81913-1", "uniprot_id": [ { "id": "OR24A_DROME", "url": "https://www.uniprot.org/uniprot/P81913", "type": "external" } ], "mass": 45679.0, "length": 398, "protein_name": "Odorant receptor 24a", "gene_name": "Or24a", "organism": "Fruit fly", "refseq_name": "odorant receptor 24a", "refseq_ac": [ { "id": "NP_523470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523470", "type": "external" } ], "gene_names_uniprotkb": "Or24a; CG11767; DOR24D.1; Or24D.1", "gene_names_refseq": "24D.1; 24a; CG11767; DOR24D.1; DOR48; Dmel\\CG11767; Or24D.1; Or24a", "protein_names_uniprotkb": "Odorant receptor 24a", "protein_names_refseq": "CG11767-PB; Or24a-PB; odorant receptor 24a; olfactory receptor 24D.1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11767)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10069338;10731132;12537572;21613503;21857978", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to pentanol, hexanol, octanol, nonanol, propyl acetate, butyl acetate, isoamyl acetate, methyl caproate, anisole, heptanal, 2-heptanone, r-carvone, and nonanoic acid. Also responds to pyrazines., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VQX1", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P81913-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81914-1", "uniprot_id": [ { "id": "OR33A_DROME", "url": "https://www.uniprot.org/uniprot/P81914", "type": "external" } ], "mass": 43892.0, "length": 378, "protein_name": "Odorant receptor 33a", "gene_name": "Or33a", "organism": "Fruit fly", "refseq_name": "odorant receptor 33a", "refseq_ac": [ { "id": "NP_523553", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523553", "type": "external" } ], "gene_names_uniprotkb": "Or33a; AN3; CG16960; DOR33B.1; Or33B.1; dor73", "gene_names_refseq": "33B.1; 33a; AN3; CG16960; DOR33B.1; DOR73; Dmel\\CG16960; OR33a; Or33B.1; Or33a; Or73; dor73", "protein_names_uniprotkb": "Odorant receptor 33a", "protein_names_refseq": "CG16960-PA; Or33a-PA; odorant receptor 33a; olfactory receptor 33B.1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG16960)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10069338;10089887;10458908;10731132;10943836;12537572", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P81914-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81916-1", "uniprot_id": [ { "id": "OR33C_DROME", "url": "https://www.uniprot.org/uniprot/P81916", "type": "external" } ], "mass": 44374.0, "length": 384, "protein_name": "Odorant receptor 33c", "gene_name": "Or33c", "organism": "Fruit fly", "refseq_name": "odorant receptor 33c", "refseq_ac": [ { "id": "NP_523555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523555", "type": "external" } ], "gene_names_uniprotkb": "Or33c; AN2; CG5006; DOR33B.3; Or33B.3; dor71", "gene_names_refseq": "33B.3; 33c; AN2; CG5006; DOR33B.3; DOR71; Dmel\\CG5006; OR33c; Or33B.3; Or33c; Or71; dor71", "protein_names_uniprotkb": "Odorant receptor 33c", "protein_names_refseq": "CG5006-PA; Or33c-PA; odorant receptor 33c; olfactory receptor 33B.3", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5006)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10069338;10089887;10458908;10731132;10943836;12537572", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P81916-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81918-1", "uniprot_id": [ { "id": "OR43B_DROME", "url": "https://www.uniprot.org/uniprot/P81918", "type": "external" } ], "mass": 46626.0, "length": 403, "protein_name": "Odorant receptor 43b", "gene_name": "Or43b", "organism": "Fruit fly", "refseq_name": "odorant receptor 43b", "refseq_ac": [ { "id": "NP_523656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523656", "type": "external" } ], "gene_names_uniprotkb": "Or43b; AN7; CG17853; DOR25A.1; OR44A.1", "gene_names_refseq": "25A.1/43; 43b; AN7; CG17853; DOR25A.1; DOR81; Dmel\\CG17853; OR43b; Or25A.1; Or43b", "protein_names_uniprotkb": "Odorant receptor 43b", "protein_names_refseq": "CG17853-PA; Or43b-PA; odorant receptor 43b; olfactory receptor 25A.1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17853)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10069338;10458908;10731132;10943836;12537572;16615896", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9U6Y0;Q9V332", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P81918-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81923-1", "uniprot_id": [ { "id": "OR59A_DROME", "url": "https://www.uniprot.org/uniprot/P81923", "type": "external" } ], "mass": 46452.0, "length": 397, "protein_name": "Odorant receptor 59a", "gene_name": "Or59a", "organism": "Fruit fly", "refseq_name": "odorant receptor 59a", "refseq_ac": [ { "id": "NP_523821", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523821", "type": "external" } ], "gene_names_uniprotkb": "Or59a; AN6; CG9820; DOR59D.1; Or59D.1; dor46", "gene_names_refseq": "59D.1; 59a; AN6; CG9820; DOR46; DOR59D.1; Dmel\\CG9820; OR59a; Or46; Or59D.1; Or59a; dor46", "protein_names_uniprotkb": "Odorant receptor 59a", "protein_names_refseq": "CG9820-PA; Or59a-PA; odorant receptor 59a; olfactory receptor 59D.1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9820)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10069338;10089887;10458908;10731132;12537572;21613503;21857978", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to ethyl acetate, anisole, hexanoic acid, and pyrazines., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9U6Y1", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P81923-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82705-1", "uniprot_id": [ { "id": "DSO1_DROME", "url": "https://www.uniprot.org/uniprot/P82705", "type": "external" } ], "mass": 4523.0, "length": 42, "protein_name": "Daisho1", "gene_name": "Dso1", "organism": "Fruit fly", "refseq_name": "Daisho1, isoform B", "refseq_ac": [ { "id": "NP_001286648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286648", "type": "external" } ], "gene_names_uniprotkb": "Dso1; CG15231; IM4", "gene_names_refseq": "BcDNA:RH25931; CG15231; DIM 4; DIM-4; DIM4; Dmel\\CG15231; Dso1; IM4; dso1", "protein_names_uniprotkb": "Daisho1; DIM-4; Immune-induced peptide 4", "protein_names_refseq": "CG15231-PB; Daisho1, isoform B; Dso1-PB; daisho1; drosophila immune-induced molecule 4; immune induced molecule 4; immune induced peptide 4", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15231)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;12171930;12537569;12537572;16510152;32038657;9736738", "class_list": "", "function": "Peptide which plays a role in the humoral immune response to a subset of filamentous fungi, including F.oxysporum and F.verticillioides., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4LG54;Q9W2Q9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006952 defense response;GO:0019731 antibacterial humoral response;GO:0019732 antifungal humoral response;GO:0045087 innate immune response;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P82705-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82983-1", "uniprot_id": [ { "id": "OR65B_DROME", "url": "https://www.uniprot.org/uniprot/P82983", "type": "external" } ], "mass": 47481.0, "length": 406, "protein_name": "Putative odorant receptor 65b", "gene_name": "Or65b", "organism": "Fruit fly", "refseq_name": "odorant receptor 65b", "refseq_ac": [ { "id": "NP_729162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_729162", "type": "external" } ], "gene_names_uniprotkb": "Or65b; CG32402", "gene_names_refseq": "65b; CG32402; DOR63; Dmel\\CG32402; LU27.1; OR65b; Or65b", "protein_names_uniprotkb": "Putative odorant receptor 65b", "protein_names_refseq": "CG32402-PA; Or65b-PA; odorant receptor 65b", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32402)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IQ67", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P82983-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83088-1", "uniprot_id": [ { "id": "FUTC_DROME", "url": "https://www.uniprot.org/uniprot/P83088", "type": "external" } ], "mass": 49130.0, "length": 425, "protein_name": "Lewis-type alpha-(1,3)-fucosyltransferase", "gene_name": "FucTC", "organism": "Fruit fly", "refseq_name": "alpha1,3-fucosyltransferase C", "refseq_ac": [ { "id": "NP_001036320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036320", "type": "external" } ], "gene_names_uniprotkb": "FucTC; CG40305", "gene_names_refseq": "CG40305; Dmel\\CG40305; FucTC", "protein_names_uniprotkb": "Lewis-type alpha-(1,3)-fucosyltransferase; 2.4.1.152", "protein_names_refseq": "CG40305-PB; FucTC-PB; alpha1,3-fucosyltransferase C; alpha1,3-fucosyltransferase", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG40305)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;11382750;12537572;16314421", "class_list": "glycogene;glycosyltransferase", "function": "Lewis-type alpha1,3-fucosyltransferase that catalyzes the addition of fucose in alpha 1-3 linkage to GlcNAc residues of terminal N-acetyllactosamine (LacNAc) or N,N'-diacetyllactosamine (LacDiNAc) units on glycan antennae (By similarity). Lacks glycoprotein core alpha1,3-fucosyltransferase activity., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7PLF1", "ec_number_list": [ { "id": "2.4.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.152", "type": "external" } ], "go_molecular_function": "GO:0008417 fucosyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P83088-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83118-1", "uniprot_id": [ { "id": "MTH11_DROME", "url": "https://www.uniprot.org/uniprot/P83118", "type": "external" } ], "mass": 62092.0, "length": 532, "protein_name": "Probable G protein-coupled receptor Mth-like 11", "gene_name": "mthl11", "organism": "Fruit fly", "refseq_name": "methuselah-like 11, isoform D", "refseq_ac": [ { "id": "NP_001262465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262465", "type": "external" } ], "gene_names_uniprotkb": "mthl11; CG31147; Mth-like-11", "gene_names_refseq": "CG31147; Dmel\\CG31147; Mthl11; mthl11", "protein_names_uniprotkb": "Probable G protein-coupled receptor Mth-like 11; Protein methuselah-like 11", "protein_names_refseq": "CG31147-PD; Mth-like 11; Mth-like-11; methuselah-like 11, isoform D; mthl11-PD", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31147)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;11274391;12537572", "class_list": "", "function": "", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4KG61;Q8INM0", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0042594 response to starvation;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P83118-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83293-1", "uniprot_id": [ { "id": "GR64A_DROME", "url": "https://www.uniprot.org/uniprot/P83293", "type": "external" } ], "mass": 52823.0, "length": 456, "protein_name": "Gustatory receptor for sugar taste 64a", "gene_name": "Gr64a", "organism": "Fruit fly", "refseq_name": "gustatory receptor 64a", "refseq_ac": [ { "id": "NP_728920", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_728920", "type": "external" } ], "gene_names_uniprotkb": "Gr64a; CG32261", "gene_names_refseq": "CG14986; CG32261; Dmel64a; Dmel\\CG32261; GR64a; GRLU.3; Gr64A1; Gr64a; Gr64; GrLU3; LU.3", "protein_names_uniprotkb": "Gustatory receptor for sugar taste 64a", "protein_names_refseq": "CG32261-PA; Gr64a-PA; gustatory receptor 64a; gustatory receptor LU.3", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32261)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;11516643;12537572;14608037;17715294;17988633;19026541;21709242;22794108;23850280;38305684", "class_list": "", "function": "One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. Required in combination with Gr64f to detect sucrose, maltose, and glucose., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VZJ7", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0033041 sweet taste receptor activity;GO:0008527 taste receptor activity;GO:0170023 ionotropic sweet taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0034220 monoatomic ion transmembrane transport;GO:0050909 sensory perception of taste;GO:0050912 detection of chemical stimulus involved in sensory perception of taste;GO:0050916 sensory perception of sweet taste", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P83293-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83294-1", "uniprot_id": [ { "id": "GR64B_DROME", "url": "https://www.uniprot.org/uniprot/P83294", "type": "external" } ], "mass": 47488.0, "length": 406, "protein_name": "Gustatory receptor for sugar taste 64b", "gene_name": "Gr64b", "organism": "Fruit fly", "refseq_name": "gustatory receptor 64b", "refseq_ac": [ { "id": "NP_728921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_728921", "type": "external" } ], "gene_names_uniprotkb": "Gr64b; 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CG9118", "gene_names_refseq": "CG9118; Dmel\\CG9118; LysD; Lys; lysD", "protein_names_uniprotkb": "Lysozyme D; 1,4-beta-N-acetylmuramidase D; 3.2.1.17", "protein_names_refseq": "CG9118-PA; LysD-PA; lysozyme D; lysozyme", "tax_id": 7227, "disease": "gastroenteritis (Disease Ontology:DOID:2326)", "pathway": " (dme:Dmel_CG9118); (R-DME-6798695); (R-DME-6803157)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10731132;12537572;1588905", "class_list": "glycogene;glycosylhydrolase", "function": "Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C9QNX1;P29614;P37157;Q9W0J6;Q9W0J7", "ec_number_list": [ { "id": "3.5.2.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.17", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.5.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.28", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "6.3.4.21", "url": 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extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P83972-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84180-1", "uniprot_id": [ { "id": "GR22B_DROME", "url": "https://www.uniprot.org/uniprot/P84180", "type": "external" } ], "mass": 45462.0, "length": 386, "protein_name": "Putative gustatory receptor 22b", "gene_name": "Gr22b", "organism": "Fruit fly", "refseq_name": "gustatory receptor 22b", "refseq_ac": [ { "id": "NP_001014456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014456", "type": "external" } ], "gene_names_uniprotkb": "Gr22b; CG31931", "gene_names_refseq": "CG31931; CR31931; Dmel\\CG31931; GR22b; Gr22bP; Gr22b; Gr2940.4", "protein_names_uniprotkb": "Putative gustatory receptor 22b", 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Seems to be involved in the sensing of bitter taste since it is expressed in neurons that mediate sensitivity to bitter compounds., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q59E12", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0008527 taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007165 signal transduction;GO:0034220 monoatomic ion transmembrane transport;GO:0050912 detection of chemical stimulus involved in sensory perception of taste", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P84180-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84181-1", "uniprot_id": [ { "id": "GR22D_DROME", "url": "https://www.uniprot.org/uniprot/P84181", "type": "external" } ], "mass": 44986.0, "length": 387, "protein_name": "Putative gustatory receptor 22d", "gene_name": "Gr22d", "organism": "Fruit fly", "refseq_name": "gustatory receptor 22d", "refseq_ac": [ { "id": "NP_001259882", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259882", "type": "external" } ], "gene_names_uniprotkb": "Gr22d; CG31930", "gene_names_refseq": "CG31930; CR31930; Dmel\\CG31930; GR22d; Gr22dP; Gr22d; Gr2940.2", "protein_names_uniprotkb": "Putative gustatory receptor 22d", "protein_names_refseq": "CG31930-PB; Gr22d-PB; gustatory receptor 22d; gustatory receptor 2940.2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31930)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;14608037;22031876", "class_list": "", "function": "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M9PBP0", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0008527 taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007165 signal transduction;GO:0034220 monoatomic ion transmembrane transport;GO:0050912 detection of chemical stimulus involved in sensory perception of taste", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P84181-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P92204-1", "uniprot_id": [ { "id": "NELFE_DROME", "url": "https://www.uniprot.org/uniprot/P92204", "type": "external" } ], "mass": 31811.0, "length": 280, "protein_name": "Negative elongation factor E", "gene_name": "Nelf-E", "organism": "Fruit fly", "refseq_name": "negative elongation factor E", "refseq_ac": [ { "id": "NP_648241", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648241", "type": "external" } ], "gene_names_uniprotkb": "Nelf-E; CG5994; anon-66Da", "gene_names_refseq": "CG5994; Dmel\\CG5994; ENelf-E; EY07065; NELF-E; NELFE; NELF; Nelf-E; Nelf-e; NelfE; Nelf_E; anon-66Da; cg5994; dNelf-E", "protein_names_uniprotkb": "Negative elongation factor E", "protein_names_refseq": "CG5994-PA; Nelf-E-PA; anonymous-66Da; negative elongation factor E; negative elongation factor", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5994); (R-DME-112382); (R-DME-113418); (R-DME-674695); (R-DME-6796648); (R-DME-75955)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;12782658;9236770", "class_list": "", "function": "Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex, causes transcriptional pausing., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0008023 transcription elongation factor complex;GO:0017053 transcription repressor complex;GO:0005694 chromosome;GO:0032021 NELF complex", "go_biological_process": "GO:0032785 negative regulation of DNA-templated transcription, elongation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034244 negative regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P92204-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98163-1", "uniprot_id": [ { "id": "YL_DROME", "url": "https://www.uniprot.org/uniprot/P98163", "type": "external" } ], "mass": 219521.0, "length": 1984, "protein_name": "Vitellogenin receptor Yl", "gene_name": "yl", "organism": "Fruit fly", "refseq_name": "yolkless, isoform A", "refseq_ac": [ { "id": "NP_511151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_511151", "type": "external" } ], "gene_names_uniprotkb": "yl; CG1372", "gene_names_refseq": "CG1372; CT3114; DmYPR; Dmel\\CG1372; LR13; YL; Yl; fs(1)148; fs(1)5; fs(1)A148; fs(1)K184; fs(1)L186; fs(1)L193; fs(1)L196; fs(1)L211; fs(1)M205; fs(1)M25; fs(1)yl; fs(1)yolkless; yl; yokeless", "protein_names_uniprotkb": "Vitellogenin receptor Yl; Protein yolkless; Yl", "protein_names_refseq": "CG1372-PA; Dm yolkless; YP receptor; yl-PA; yolkless, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1372)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10679010;10731132;12537572;18327897;2886508;33891588;33925313;7878005", "class_list": "", "function": "Cell surface receptor involved in uptake of vitellogenins (yolk proteins) into developing oocytes by receptor-mediated endocytosis (PubMed:10679010, PubMed:2886508, PubMed:7878005). May also mediate uptake of apolpp/apolipophorins and their incorporation into yolk granules (PubMed:33891588). Along with its ligands, required for maintenance of microtubule plus-end orientation towards the posterior pole of oocytes (PubMed:33891588). Involved in polarized localization of germ plasm components, such as osk mRNA and vas protein, to the oocyte posterior cortex (PubMed:33891588). Receptor-mediated endocytosis of vitellogenin receptor ligands is critical for osk (isoform A) mediated actin reorganization and the anchoring of germ plasm components to the oocyte cortex (PubMed:33891588)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 14, "predicted_n_glycosites": 13, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "Q86P52;Q9VY56", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008196 vitellogenin receptor activity", "go_cellular_component": "GO:0030135 coated vesicle;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0031410 cytoplasmic vesicle;GO:0031901 early endosome membrane", "go_biological_process": "GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P98163-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00748-1", "uniprot_id": [ { "id": "MDR65_DROME", "url": "https://www.uniprot.org/uniprot/Q00748", "type": "external" } ], "mass": 143784.0, "length": 1302, "protein_name": "Multidrug resistance protein homolog 65", "gene_name": "Mdr65", "organism": "Fruit fly", "refseq_name": "multi drug resistance 65", "refseq_ac": [ { "id": "NP_476831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476831", "type": "external" } ], "gene_names_uniprotkb": "Mdr65; CG10181", "gene_names_refseq": "CG10181; DmMdr65; Dmel\\CG10181; MDR65; Mdr65A; Mdr65; P-glycoprotein; P-gp; mdr65", "protein_names_uniprotkb": "Multidrug resistance protein homolog 65; 7.6.2.2; P-glycoprotein 65", "protein_names_refseq": "CG10181-PA; MDR65; Mdr65-PA; P-glycoprotein65-Dm; multi drug resistance 65; multiple drug resistance 65", "tax_id": 7227, "disease": "obstructive sleep apnea (Disease Ontology:DOID:0050848); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); familial temporal lobe epilepsy 3 (Disease Ontology:DOID:0060750); progressive familial intrahepatic cholestasis 3 (Disease Ontology:DOID:0070223); intrahepatic cholestasis of pregnancy 3 (Disease Ontology:DOID:0070229); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); nasal type extranodal NK/T-cell lymphoma (Disease Ontology:DOID:0080797); inflammatory bowel disease 13 (Disease Ontology:DOID:0110893); osteonecrosis (Disease Ontology:DOID:10159); antisocial personality disorder (Disease Ontology:DOID:10939); familial hyperlipidemia (Disease Ontology:DOID:1168); primary biliary cholangitis (Disease Ontology:DOID:12236); malaria (Disease Ontology:DOID:12365); Behcet's disease (Disease Ontology:DOID:13241); hepatic encephalopathy (Disease Ontology:DOID:13413); cholestasis (Disease Ontology:DOID:13580); cystic fibrosis (Disease Ontology:DOID:1485); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); cannabis dependence (Disease Ontology:DOID:1849); intrahepatic cholestasis (Disease Ontology:DOID:1852); cholecystitis (Disease Ontology:DOID:1949); nephroblastoma (Disease Ontology:DOID:2154); brain ischemia (Disease Ontology:DOID:2316); ovarian cancer (Disease Ontology:DOID:2394); opiate dependence (Disease Ontology:DOID:2559); asthma (Disease Ontology:DOID:2841); cryoglobulinemia (Disease Ontology:DOID:2917); pulmonary tuberculosis (Disease Ontology:DOID:2957); familial Mediterranean fever (Disease Ontology:DOID:2987); invasive ductal carcinoma (Disease Ontology:DOID:3008); high grade glioma (Disease Ontology:DOID:3070); temporal lobe epilepsy (Disease Ontology:DOID:3328); toxic encephalopathy (Disease Ontology:DOID:3602); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); allergic rhinitis (Disease Ontology:DOID:4481); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); chronic myeloid leukemia (Disease Ontology:DOID:8552); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dme:Dmel_CG10181)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;11012721;12537572;17893096;2072901", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 50, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9VRW3", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0008559 ABC-type xenobiotic transporter activity;GO:0016887 ATP hydrolysis activity;GO:0015562 efflux transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0043190 ATP-binding cassette (ABC) transporter complex;GO:0005919 pleated septate junction", "go_biological_process": "GO:0055085 transmembrane transport;GO:0009636 response to toxic substance;GO:0017085 response to insecticide;GO:0060857 establishment of glial blood-brain barrier;GO:0097254 renal tubular secretion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q00748-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01637-1", "uniprot_id": [ { "id": "UMPS_DROME", "url": "https://www.uniprot.org/uniprot/Q01637", "type": "external" } ], "mass": 53419.0, "length": 493, "protein_name": "Uridine 5'-monophosphate synthase", "gene_name": "r-l", "organism": "Fruit fly", "refseq_name": "rudimentary-like", "refseq_ac": [ { "id": "NP_524427", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524427", "type": "external" } ], "gene_names_uniprotkb": "r-l; CG3593", "gene_names_refseq": "CG3593; Dmel\\CG3593; OMPDC; OPRT; UMPS; r-l; ral", "protein_names_uniprotkb": "Uridine 5'-monophosphate synthase; OMPdecase; Rudimentary-like protein; UMP synthase", "protein_names_refseq": "CG3593-PA; UMP synthase; orotidine phosphate decarboxylase; r-l-PA; rudimentary-like", "tax_id": 7227, "disease": "orotic aciduria (Disease Ontology:DOID:0050833); purine-pyrimidine metabolic disorder (Disease Ontology:DOID:653)", "pathway": " (dme:Dmel_CG3593); (R-DME-500753)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;2122228;8444350", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24221;Q9VDF2", "ec_number_list": [ { "id": "2.4.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.10", "type": "external" }, { "id": "4.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.23", "type": "external" } ], "go_molecular_function": "GO:0004588 orotate phosphoribosyltransferase activity;GO:0004590 orotidine-5'-phosphate decarboxylase activity", "go_cellular_component": "", "go_biological_process": "GO:0006222 UMP biosynthetic process;GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process;GO:0044205 'de novo' UMP biosynthetic process;GO:0019856 pyrimidine nucleobase biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q01637-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01642-1", "uniprot_id": [ { "id": "MS84A_DROME", "url": "https://www.uniprot.org/uniprot/Q01642", "type": "external" } ], "mass": 5806.0, "length": 63, "protein_name": "Male-specific sperm protein Mst84Da", "gene_name": "Mst84Da", "organism": "Fruit fly", "refseq_name": "Male-specific RNA 84Da", "refseq_ac": [ { "id": "NP_524256", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524256", "type": "external" } ], "gene_names_uniprotkb": "Mst84Da; CG17946", "gene_names_refseq": "CG17946; Dmel\\CG17946; Mst ORF; Mst84Da; Mst84; Mst87D; Mstprox; Mst; mst(3)gl-1", "protein_names_uniprotkb": "Male-specific sperm protein Mst84Da", "protein_names_refseq": "CG17946-PA; Male-specific RNA 84Da; Mst84Da-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17946)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;1684716", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VIA3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007288 sperm axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q01642-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01644-1", "uniprot_id": [ { "id": "MS84C_DROME", "url": "https://www.uniprot.org/uniprot/Q01644", "type": "external" } ], "mass": 5225.0, "length": 55, "protein_name": "Male-specific sperm protein Mst84Dc", "gene_name": "Mst84Dc", "organism": "Fruit fly", "refseq_name": "Male-specific RNA 84Dc, isoform B", "refseq_ac": [ { "id": "NP_001097701", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097701", "type": "external" } ], "gene_names_uniprotkb": "Mst84Dc; CG17945", "gene_names_refseq": "CG17945; Dmel\\CG17945; Mst ORF; Mst84Dc; Mst84D; Mst84; Mst87D; Mstprox; Mst; mst(3)gl-3", "protein_names_uniprotkb": "Male-specific sperm protein Mst84Dc", "protein_names_refseq": "CG17945-PB; Male-specific RNA 84Dc, isoform B; Mst84Dc-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17945)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;1684716", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8JQU9;Q4V3L6;Q9VIA0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007288 sperm axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q01644-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02361-1", "uniprot_id": [ { "id": "FD3_DROME", "url": "https://www.uniprot.org/uniprot/Q02361", "type": "external" } ], "mass": 49054.0, "length": 456, "protein_name": "Fork head domain-containing protein FD3", "gene_name": "fd59A", "organism": "Fruit fly", "refseq_name": "forkhead domain 59A", "refseq_ac": [ { "id": "NP_523814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523814", "type": "external" } ], "gene_names_uniprotkb": "fd59A; CG3668; FD3", "gene_names_refseq": "CG3668; Dmel\\CG3668; Dmfd3; FD3; FD59A; Fd59a; FoxD; fd3; fd59A; fd59a; foxd", "protein_names_uniprotkb": "Fork head domain-containing protein FD3", "protein_names_refseq": "CG3668-PA; fd59A-PA; forkhead domain 59A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3668)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;1356269", "class_list": "", "function": "Involved in development during embryogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LZ28;Q8T4G1;Q9W1Y5", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q02361-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04652-1", "uniprot_id": [ { "id": "KELC_DROME", "url": "https://www.uniprot.org/uniprot/Q04652", "type": "external" } ], "mass": 160094.0, "length": 1477, "protein_name": "Ring canal kelch protein", "gene_name": "kel", "organism": "Fruit fly", "refseq_name": "kelch, isoform B", "refseq_ac": [ { "id": "NP_476589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476589", "type": "external" } ], "gene_names_uniprotkb": "kel; CG7210", "gene_names_refseq": "CG7210; Dm.Ring_canal/KELC_DROME; Dmel\\CG7210; Kelch; Kel; kel", "protein_names_uniprotkb": "Ring canal kelch protein", "protein_names_refseq": "CG7210-PB; kel-PB; kelch, isoform B; kelch", "tax_id": 7227, "disease": "pseudohypoaldosteronism (Disease Ontology:DOID:4479)", "pathway": " (dme:Dmel_CG7210); (R-DME-8951664); (R-DME-983168)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10731132;11854310;12537572;18327897;21994247;8453663;9118811", "class_list": "", "function": "Component of ring canals that regulates the flow of cytoplasm between cells. May be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis. Binds actin., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F0JAF0;Q04653;Q86PA7;Q9VJA2", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0035183 female germline ring canal inner rim;GO:0035324 female germline ring canal", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0048477 oogenesis;GO:0007300 ovarian nurse cell to oocyte transport;GO:0030723 ovarian fusome organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q04652-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05913-1", "uniprot_id": [ { "id": "T2FA_DROME", "url": "https://www.uniprot.org/uniprot/Q05913", "type": "external" } ], "mass": 64467.0, "length": 577, "protein_name": "General transcription factor IIF subunit 1", "gene_name": "TfIIFalpha", "organism": "Fruit fly", "refseq_name": "transcription factor IIFalpha", "refseq_ac": [ { "id": "NP_524246", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524246", "type": "external" } ], "gene_names_uniprotkb": "TfIIFalpha; CG10281", "gene_names_refseq": "154355_at; CG10281; DmTFIIF; Dmel\\CG10281; F5a; TFIIF-L; TFIIFalpha; TFIIFa; TFIIF; TfIIFalpha; TfIIF", "protein_names_uniprotkb": "General transcription factor IIF subunit 1; TF5A; TFIIF-alpha; Transcription factor 5 large chain; Transcription initiation factor IIF subunit alpha", "protein_names_refseq": "CG10281-PA; TFIIF large subunit; TfIIFalpha-PA; factor 5a; large subunit of transcription factor 5; transcription factor IIFalpha", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10281); (R-DME-112382); (R-DME-113418); (R-DME-674695); (R-DME-6796648); (R-DME-6807505); (R-DME-72086); (R-DME-72163); (R-DME-72165); (R-DME-72203); (R-DME-73776); (R-DME-73779); (R-DME-75953); (R-DME-75955); (R-DME-76042); (R-DME-77075); (R-DME-9018519); (R-DME-9770562)", "pathway_count": 18, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;18327897;8175788;8464716;8464745", "class_list": "", "function": "TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9VI19", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0001096 TFIIF-class transcription factor complex binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005674 transcription factor TFIIF complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006368 transcription elongation by RNA polymerase II;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q05913-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06521-1", "uniprot_id": [ { "id": "VTU3_DROME", "url": "https://www.uniprot.org/uniprot/Q06521", "type": "external" } ], "mass": 11954.0, "length": 119, "protein_name": "Vitelline membrane protein Vm34Ca", "gene_name": "Vm34Ca", "organism": "Fruit fly", "refseq_name": "vitelline membrane 34Ca", "refseq_ac": [ { "id": "NP_476785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476785", "type": "external" } ], "gene_names_uniprotkb": "Vm34Ca; CG9271; VM34C.1", "gene_names_refseq": "CG9271; Dmel\\CG9271; VM26A.1; VM34C.1; VM34Ca; VM34C; Vm34Ca; Vm34Cc; Vm34C", "protein_names_uniprotkb": "Vitelline membrane protein Vm34Ca", "protein_names_refseq": "CG9271-PA; Vm34Ca-PA; vitelline membrane 34Ca", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9271)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537572;17244601;3143615;3926479;8293994", "class_list": "", "function": "Major early eggshell protein., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0JQ51;A0JQ52;A4UM24;Q9VJY2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0060388 vitelline envelope", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q06521-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08694-1", "uniprot_id": [ { "id": "LYSB_DROME", "url": "https://www.uniprot.org/uniprot/Q08694", "type": "external" } ], "mass": 15612.0, "length": 140, "protein_name": "Lysozyme B", "gene_name": "LysB", "organism": "Fruit fly", "refseq_name": "lysozyme B, isoform B", "refseq_ac": [ { "id": "NP_001261245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261245", "type": "external" } ], "gene_names_uniprotkb": "LysB; CG1179", "gene_names_refseq": "CG1179; Dmel\\CG1179; Lys B; LysB; lysB", "protein_names_uniprotkb": "Lysozyme B; 1,4-beta-N-acetylmuramidase B; 3.2.1.17", "protein_names_refseq": "CG1179-PB; LysB-PB; lysozyme B, isoform B; lyzozyme B", "tax_id": 7227, "disease": "gastroenteritis (Disease Ontology:DOID:2326)", "pathway": " (dme:Dmel_CG1179); (R-DME-6798695); (R-DME-6803157)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10731132;12537572;8159165", "class_list": "glycogene;glycosylhydrolase", "function": "Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P37158;Q9W0J8", "ec_number_list": [ { "id": "3.5.2.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.17", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.5.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.28", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.4.17.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.13", "type": "external" }, { "id": "1.11.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.-", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q08694-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0KHV6-1", "uniprot_id": [ { "id": "PINK1_DROME", "url": "https://www.uniprot.org/uniprot/Q0KHV6", "type": "external" } ], "mass": 80228.0, "length": 721, "protein_name": "Serine/threonine-protein kinase Pink1, mitochondrial", "gene_name": "Pink1", "organism": "Fruit fly", "refseq_name": "PTEN-induced putative kinase 1, isoform H", "refseq_ac": [ { "id": "NP_001027049", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027049", "type": "external" } ], "gene_names_uniprotkb": "Pink1; CG4523", "gene_names_refseq": "BEST:GH23468; CG4523; Dmel\\CG4523; PINK-1; PINK1; Pink1; Pink; dPINK1; dPINk1; dPink1; dpink; pink1", "protein_names_uniprotkb": "Serine/threonine-protein kinase Pink1, mitochondrial; 2.7.11.1; PTEN-induced putative kinase 1", "protein_names_refseq": "CG4523-PH; PINK1; PTEN induced putative kinase 1; PTEN-induced kinase 1; PTEN-induced putative kinase 1, isoform H; PTEN-induced putative kinase 1; Pink1-PH; Pten-induced kinase 1(PINK1); ortholog of PINK1; phosphatase and tensin homolog-induced putative kinase 1; pink", "tax_id": 7227, "disease": "Parkinson's disease 6 (Disease Ontology:DOID:0060369); early-onset Parkinson's disease (Disease Ontology:DOID:0060894); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); Parkinsonism (Disease Ontology:DOID:0080855); Hirschsprung's disease (Disease Ontology:DOID:10487); Parkinson's disease (Disease Ontology:DOID:14330); testicular cancer (Disease Ontology:DOID:2998)", "pathway": " (dme:Dmel_CG4523); (R-DME-5205685)", "pathway_count": 2, "publication_count": 24, "publication_id_list": "10731132;12537569;12537572;16672980;16672981;16818890;16938835;18230723;18443288;18799731;18957282;19048081;20194754;22396657;22645651;23509287;24901221;25474007;27906179;28435104;29563254;30772175;32138754;32484300", "class_list": "", "function": "Acts as a serine/threonine-protein kinase (PubMed:16672980, PubMed:16672981, PubMed:16818890, PubMed:16938835, PubMed:18230723, PubMed:18443288, PubMed:18799731, PubMed:18957282, PubMed:20194754, PubMed:22645651, PubMed:24901221, PubMed:25474007, PubMed:32484300). Exhibits a substrate preference for proline at position P+1 and a general preference at several residues for basic residues such as arginine (By similarity). Also exhibits moderate preferences for a phosphotyrosine at position P-3 and a tryptophan at P-5 (By similarity). Critical to mitochondrial homeostasis it mediates several pathways that maintain mitochondrial health and function (PubMed:16672980, PubMed:16672981, PubMed:16818890, PubMed:16938835, PubMed:18230723, PubMed:18443288, PubMed:18799731, PubMed:18957282, PubMed:20194754, PubMed:22645651, PubMed:24901221, PubMed:25474007, PubMed:29563254, PubMed:30772175, PubMed:32484300). Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins such as park and likely Drp1, to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:16672980, PubMed:16672981, PubMed:16818890, PubMed:16938835, PubMed:18230723, PubMed:18443288, PubMed:18799731, PubMed:18957282, PubMed:20194754, PubMed:22645651, PubMed:24901221, PubMed:25474007, PubMed:32484300). Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed:16672980, PubMed:16672981, PubMed:16818890, PubMed:16938835, PubMed:18230723, PubMed:18443288, PubMed:18799731, PubMed:18957282, PubMed:20194754, PubMed:23509287, PubMed:24901221, PubMed:25474007). Appears to be particularly important in maintaining the physiology and function of cells with high energy demands that are undergoing stress or altered metabolic environment, including spermatids, muscle cells and neurons such as the dopaminergic (DA) neurons (PubMed:16672980, PubMed:16672981, PubMed:16818890, PubMed:16938835, PubMed:18443288, PubMed:18799731, PubMed:22396657, PubMed:24901221, PubMed:28435104, PubMed:29563254, PubMed:32138754). Mediates the translocation and activation of park at the outer membrane (OMM) of dysfunctional/depolarized mitochondria (PubMed:18799731, PubMed:18957282, PubMed:20194754, PubMed:24901221, PubMed:25474007, PubMed:27906179). At the OMM of damaged mitochondria, phosphorylates pre-existing polyubiquitin chains, the Pink1-phosphorylated polyubiquitin then recruits park from the cytosol to the OMM where park is fully activated by phosphorylation at 'Ser-94' by Pink1 (PubMed:18799731, PubMed:18957282, PubMed:20194754, PubMed:24901221, PubMed:25474007, PubMed:27906179). When cellular stress results in irreversible mitochondrial damage, functions with park to promote the clearance of dysfunctional and/or depolarized mitochondria by selective autophagy (mitophagy) (PubMed:16672980, PubMed:16672981, PubMed:18957282, PubMed:20194754, PubMed:23509287, PubMed:25474007). The Pink1-park pathway also promotes fission and/or inhibits fusion of damaged mitochondria, by phosphorylating and thus promoting the park-dependent degradation of proteins involved in mitochondrial fusion/fission such as Marf, Opa1 and fzo (PubMed:18230723, PubMed:18443288, PubMed:18799731, PubMed:20194754, PubMed:24901221, PubMed:29563254). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed:18230723, PubMed:18443288, PubMed:18799731, PubMed:20194754, PubMed:24901221). Also likely to promote mitochondrial fission independently of park and Atg7-mediated mitophagy, via the phosphorylation and activation of Drp1 (PubMed:18443288, PubMed:32484300). Regulates motility of damaged mitochondria by phosphorylating Miro which likely promotes its park-dependent degradation by the proteasome; in motor neurons, this inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria being eliminated in the soma (PubMed:22396657). The Pink1-park pathway is also involved in mitochondrial regeneration processes such as promoting mitochondrial biogenesis, activating localized mitochondrial repair, promoting selective turnover of mitochondrial proteins and initiating the mitochondrial import of endogenous proteins (PubMed:16672980, PubMed:23509287, PubMed:30772175). Involved in mitochondrial biogenesis by promoting the park-dependent ubiquitination of transcriptional repressor Paris which leads to its subsequent proteasomal degradation and allows activation of the transcription factor srl (PubMed:32138754). Functions with park to promote localized mitochondrial repair by activating the translation of specific nuclear-encoded mitochondrial RNAs (nc-mtRNAs) on the mitochondrial surface, including several key electron transport chain component nc-mtRNAs (PubMed:23509287). During oogenesis, phosphorylates and inactivates larp on the membrane of defective mitochondria, thus impairing local translation and mtDNA replication and consequently, reducing transmission of deleterious mtDNA mutations to the mature oocyte (PubMed:30772175). Phosphorylates the mitochondrial acyl-CoA dehydrogenase Mcad, and appears to be important for maintaining fatty acid and amino acid metabolism via a mechanism that is independent of its role in maintaining production of ATP (PubMed:29563254)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q961J3", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0043008 ATP-dependent protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol", "go_biological_process": "GO:0030382 sperm mitochondrion organization;GO:0047497 mitochondrion transport along microtubule;GO:0048749 compound eye development;GO:0006468 protein phosphorylation;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q0KHV6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q23978-1", "uniprot_id": [ { "id": "MY31D_DROME", "url": "https://www.uniprot.org/uniprot/Q23978", "type": "external" } ], "mass": 117095.0, "length": 1011, "protein_name": "Unconventional myosin ID", "gene_name": "Myo31DF", "organism": "Fruit fly", "refseq_name": "myosin 31DF, isoform C", "refseq_ac": [ { "id": "NP_001188784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188784", "type": "external" } ], "gene_names_uniprotkb": "Myo31DF; CG7438; Myo1D", "gene_names_refseq": "CG7438; Dm IA; DmIA; Dmel\\CG7438; DroMIA; IA; MYOIA; Mhc1; Myo-IA; Myo1A; Myo1D; Myo1a; Myo31DF; MyoIA; MyoID; mhc1; myo1D; myo31DF; myoID; souther", "protein_names_uniprotkb": "Unconventional myosin ID; BBMIA; Brush border myosin IA; MIA; Myo1D; MyoIA; MyoID; Myosin 1D; Myosin-IA", "protein_names_refseq": "CG7438-PC; Myo31DF-PC; Myosin31DF; myosin 1D; myosin 1a; myosin 31DF, isoform C; myosin IA; myosin ID; myosin-IA; myosin1A; souther; type ID unconventional myosin 31DF; unconventional myosin 31DF", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7438)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537569;12537572;16598258;16598259;18521948;22491943;25659376;26073018;30467170;7589814;8201616", "class_list": "", "function": "Unconventional myosin that functions as actin-based motor protein with ATPase activity (PubMed:30467170). Binds to membranes enriched in phosphatidylinositol 4-5-bisphosphate, and can glide along actin filaments when anchored to a lipid bilayer (PubMed:30467170). Generates left-right asymmetry at the level of single cells, organs and the whole body via its interaction with the actin cytoskeleton, both in the embryo and the adult (PubMed:16598258, PubMed:16598259, PubMed:18521948, PubMed:25659376, PubMed:26073018, PubMed:30467170). Normal left-right asymmetry of the larval midgut and hindgut requires expression in the embryonic hindgut epithelium during a critical time period, 10 to 12.75 hours after egg laying (PubMed:18521948). This period corresponds to a late stage of germband retraction, and precedes left-right asymmetric morphogenesis (PubMed:18521948). Expression in segment H1 of the imaginal ring is required at 0 to 24 hours after pupation for changes of cell shape and orientation in the H2 segment, which then gives rise to normal, dextral looping of the adult hindgut (PubMed:16598258, PubMed:26073018). Required during a critical period, 126-132 hours after egg laying, for normal, dextral rotation of the adult male genitalia (PubMed:16598258, PubMed:16598259, PubMed:22491943, PubMed:25659376, PubMed:26073018). Has a double role by promoting dextral rotation in the posterior compartment of segment A8 of the male genital disk, and in repressing sinistral looping in the anterior compartment (PubMed:16598259)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V0K5;M9MRS7", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005938 cell cortex;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0061525 hindgut development;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0030048 actin filament-based movement;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q23978-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q23979-1", "uniprot_id": [ { "id": "MY61F_DROME", "url": "https://www.uniprot.org/uniprot/Q23979", "type": "external" } ], "mass": 118990.0, "length": 1035, "protein_name": "Unconventional myosin IC", "gene_name": "Myo61F", "organism": "Fruit fly", "refseq_name": "myosin 61F, isoform D", "refseq_ac": [ { "id": "NP_476934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476934", "type": "external" } ], "gene_names_uniprotkb": "Myo61F; CG9155; Myo1C", "gene_names_refseq": "CG9155; Dm IB; DmIB; Dmel\\CG9155; DroMIB; IB; MIB; MYO61F; MYOIB; Mhc2; Myo-IB; Myo1B; Myo1C; Myo61F; MyoIB; MyoIC; myo1C; myo61F; myo61f; myoIC", "protein_names_uniprotkb": "Unconventional myosin IC; BBMIB; Brush border myosin IB; MIB; Myo1C; MyoIC; Myosin-IB; Unconventional myosin 1C", "protein_names_refseq": "CG9155-PD; Myo61F-PD; Myosin-IB; myosin 1b; myosin 61F, isoform D; myosin 61F; myosin IB; myosin61F", "tax_id": 7227, "disease": "congenital central hypoventilation syndrome (Disease Ontology:DOID:0060731)", "pathway": " (dme:Dmel_CG9155)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537569;12537572;16598258;17372656;18521948;22491943;25659376;30467170;7589814;8201616;8216259", "class_list": "", "function": "Unconventional myosin that functions as actin-based motor protein with ATPase activity (PubMed:30467170). Binds to membranes enriched in phosphatidylinositol 4-5-bisphosphate, and can glide along actin filaments when anchored to a lipid bilayer (PubMed:30467170). Functions as antagonist for Myo31DF, an unconventional myosin with an essential role in the establishment of body left-right asymmetry (PubMed:16598258, PubMed:18521948, PubMed:22491943, PubMed:25659376, PubMed:30467170)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V191;Q7KVC1;Q8T0U8;Q9W0H0", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0005938 cell cortex;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0030048 actin filament-based movement;GO:0007368 determination of left/right symmetry;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q23979-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24119-5", "uniprot_id": [ { "id": "TRH_DROME", "url": "https://www.uniprot.org/uniprot/Q24119", "type": "external" } ], "mass": 109260.0, "length": 1022, "protein_name": "Protein trachealess", "gene_name": "trh", "organism": "Fruit fly", "refseq_name": "trachealess, isoform E", "refseq_ac": [ { "id": "NP_001261208", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261208", "type": "external" } ], "gene_names_uniprotkb": "trh; CG6883", "gene_names_refseq": "3.1; BP1081; CG13885; CG42865; CG6883; DMU42699; Dmel\\CG42865; HDC07747; TRH; Trh; bHLHe13; l(3)10512; trh", "protein_names_uniprotkb": "Protein trachealess", "protein_names_refseq": "CG42865-PE; trachealess, isoform E; trachealess; trh-PE", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42865)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10502111;10731132;11740943;12537569;12537572;21994247;8557189;8557198;9374395", "class_list": "", "function": "Transcription factor, master regulator of tracheal cell fates in the embryo, necessary for the development of the salivary gland duct, Malpighian tubules and the posterior spiracles (PubMed:10502111, PubMed:8557189, PubMed:8557198, PubMed:9374395). It may induce a general fate of branched tubular structures of epithelial origin (PubMed:10502111, PubMed:8557189, PubMed:8557198). Functions with tgo to regulate expression of btl (PubMed:9374395)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A8JNH0;A8WHG8;Q0E8K2;Q24165;Q8SX13;Q9W0Q7", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0072175 epithelial tube formation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007431 salivary gland development", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q24119-5", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24134-1", "uniprot_id": [ { "id": "NELFD_DROME", "url": "https://www.uniprot.org/uniprot/Q24134", "type": "external" } ], "mass": 65781.0, "length": 578, "protein_name": "Negative elongation factor D", "gene_name": "TH1", "organism": "Fruit fly", "refseq_name": "TH1, isoform B", "refseq_ac": [ { "id": "NP_001285326", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285326", "type": "external" } ], "gene_names_uniprotkb": "TH1; CG9984; Dmel\\CG9984; Dmel_CG9984; NELF-D; NELF; Nelf-D; NelfD", "gene_names_refseq": "CG9984; Dmel\\CG9984; NELF-D; NELF; Nelf-D; NelfD; TH1", "protein_names_uniprotkb": "Negative elongation factor D", "protein_names_refseq": "CG9984-PB; TH1, isoform B; TH1-PB", "tax_id": 7227, "disease": "prostate cancer (Disease Ontology:DOID:10283); colon cancer (Disease Ontology:DOID:219); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG9984); (R-DME-112382); (R-DME-113418); (R-DME-674695); (R-DME-6796648); (R-DME-75955)", "pathway_count": 6, "publication_count": 16, "publication_id_list": "10731132;11030415;12537568;12537569;12537572;12537573;12537574;12782658;15741180;16110336;17569856;17569867;25589440;26109356;26109357;7671309", "class_list": "", "function": "Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex, causes transcriptional pausing., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24553;Q9V418", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0008023 transcription elongation factor complex;GO:0017053 transcription repressor complex;GO:0032021 NELF complex;GO:0005703 polytene chromosome puff", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0034244 negative regulation of transcription elongation by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q24134-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24143-1", "uniprot_id": [ { "id": "HR96_DROME", "url": "https://www.uniprot.org/uniprot/Q24143", "type": "external" } ], "mass": 81029.0, "length": 723, "protein_name": "Nuclear hormone receptor HR96", "gene_name": "Hr96", "organism": "Fruit fly", "refseq_name": "hormone receptor-like in 96", "refseq_ac": [ { "id": "NP_524493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524493", "type": "external" } ], "gene_names_uniprotkb": "Hr96; CG11783; NR1J1", "gene_names_refseq": "CG11783; DHR96; Dhr96; Dmel\\CG11783; HR96; Hr96; NR1J1; dHR96", "protein_names_uniprotkb": "Nuclear hormone receptor HR96; Nuclear receptor subfamily 1 group J member 1; dHR96", "protein_names_refseq": "CG11783-PA; Hr96-PA; hormone receptor-like in 96", "tax_id": 7227, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); primary sclerosing cholangitis (Disease Ontology:DOID:0060643); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); erythema nodosum (Disease Ontology:DOID:0080750); vitamin D-dependent rickets (Disease Ontology:DOID:0080883); vitamin D-dependent rickets type 2A (Disease Ontology:DOID:0080884); autosomal recessive limb-girdle muscular dystrophy type 2B (Disease Ontology:DOID:0110276); pigmentation disease (Disease Ontology:DOID:10123); prostate cancer (Disease Ontology:DOID:10283); pre-eclampsia (Disease Ontology:DOID:10591); rickets (Disease Ontology:DOID:10609); primary hyperparathyroidism (Disease Ontology:DOID:11202); osteoporosis (Disease Ontology:DOID:11476); polycystic ovary syndrome (Disease Ontology:DOID:11612); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); gestational diabetes (Disease Ontology:DOID:11714); myopia (Disease Ontology:DOID:11830); otosclerosis (Disease Ontology:DOID:12185); primary biliary cholangitis (Disease Ontology:DOID:12236); vitiligo (Disease Ontology:DOID:12306); Graves' disease (Disease Ontology:DOID:12361); secondary hyperparathyroidism (Disease Ontology:DOID:12466); Behcet's disease (Disease Ontology:DOID:13241); cholestasis (Disease Ontology:DOID:13580); peptic esophagitis (Disease Ontology:DOID:13976); Parkinson's disease (Disease Ontology:DOID:14330); Fabry disease (Disease Ontology:DOID:14499); breast cancer (Disease Ontology:DOID:1612); aortic valve stenosis (Disease Ontology:DOID:1712); squamous cell carcinoma (Disease Ontology:DOID:1749); epilepsy (Disease Ontology:DOID:1826); melanoma (Disease Ontology:DOID:1909); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); multiple sclerosis (Disease Ontology:DOID:2377); basal cell carcinoma (Disease Ontology:DOID:2513); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); atopic dermatitis (Disease Ontology:DOID:3310); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); Turner syndrome (Disease Ontology:DOID:3491); tuberculosis (Disease Ontology:DOID:399); esophagus adenocarcinoma (Disease Ontology:DOID:4914); liver cirrhosis (Disease Ontology:DOID:5082); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); pneumonia (Disease Ontology:DOID:552); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); hematopoietic system disease (Disease Ontology:DOID:74); retinal degeneration (Disease Ontology:DOID:8466); psoriasis (Disease Ontology:DOID:8893); skin melanoma (Disease Ontology:DOID:8923); diabetic retinopathy (Disease Ontology:DOID:8947); Barrett's esophagus (Disease Ontology:DOID:9206); cholangitis (Disease Ontology:DOID:9446); steatotic liver disease (Disease Ontology:DOID:9452); alopecia (Disease Ontology:DOID:987)", "pathway": " (dme:Dmel_CG11783); (R-DME-196791); (R-DME-383280); (R-DME-4090294)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;7479849", "class_list": "", "function": "Binds selectively to the HSP27 20E response element., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 58, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VBZ7", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0042594 response to starvation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q24143-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24169-1", "uniprot_id": [ { "id": "ORC5_DROME", "url": "https://www.uniprot.org/uniprot/Q24169", "type": "external" } ], "mass": 52115.0, "length": 460, "protein_name": "Origin recognition complex subunit 5", "gene_name": "Orc5", "organism": "Fruit fly", "refseq_name": "origin recognition complex subunit 5", "refseq_ac": [ { "id": "NP_477132", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477132", "type": "external" } ], "gene_names_uniprotkb": "Orc5; CG7833", "gene_names_refseq": "BG:DS00941.8; CG7833; D-orc5; DmORC5; DmOrc5; Dmel\\CG7833; ORC5; ORC; Orc5; br39; dORC5; l(2)34Df; l(2)br39; orc5", "protein_names_uniprotkb": "Origin recognition complex subunit 5", "protein_names_refseq": "CG7833-PA; Orc5-PA; lethal(2)34Df; origin recognition complex subunit 5", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7833); (R-DME-176187); (R-DME-68616); (R-DME-68689); (R-DME-68949); (R-DME-68962)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "10471707;10731132;12537569;12537572;7502079", "class_list": "", "function": "Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V398", "ec_number_list": [], "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0005524 ATP binding;GO:0043021 ribonucleoprotein complex binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005664 nuclear origin of replication recognition complex", "go_biological_process": "GO:0006260 DNA replication;GO:0007076 mitotic chromosome condensation;GO:0006270 DNA replication initiation;GO:0007052 mitotic spindle organization;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q24169-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24314-1", "uniprot_id": [ { "id": "VPS18_DROME", "url": "https://www.uniprot.org/uniprot/Q24314", "type": "external" } ], "mass": 115334.0, "length": 1002, "protein_name": "Vacuolar protein sorting-associated protein 18 homolog", "gene_name": "dor", "organism": "Fruit fly", "refseq_name": "deep orange", "refseq_ac": [ { "id": "NP_477286", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477286", "type": "external" } ], "gene_names_uniprotkb": "dor; CG3093; Vps18", "gene_names_refseq": "CG3093; DOR; Deep-orange; Dmel\\CG3093; Dof; Dor; EG:171E4.1; FI09617; Vps18/dor; Vps18; dor1; dor; l(1)2Be; l(1)2Bw; l(1)76; l(1)7; vps18", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 18 homolog; Protein deep orange", "protein_names_refseq": "CG3093-PA; Deep-orange; deep orange; dor-PA", "tax_id": 7227, "disease": "cholestasis (Disease Ontology:DOID:13580)", "pathway": " (dme:Dmel_CG3093)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10549280;10731132;10731137;12537569;12537572;18327897;20194640;22160599;24554766;25422373;27253064;28063257;31194677;9065698", "class_list": "", "function": "Core component of the class C core vacuole/endosome tethering (CORVET) and the homotypic fusion and vacuole protein sorting (HOPS) tethering complexes involved in endo-lysosomal vesicle trafficking and lysosome biogenesis (PubMed:10549280, PubMed:24554766, PubMed:25422373, PubMed:27253064, PubMed:28063257, PubMed:31194677, PubMed:9065698). The CORVET complex facilitates docking and fusion of endosomal vesicles during endosome maturation, acts upstream of HOPS, but is not involved in autophagic flux (PubMed:10549280, PubMed:25422373, PubMed:27253064, PubMed:31194677). The CORVET complex may cooperate with the early endosomal tether Rbsn-5 to mediate endosomal fusion (PubMed:27253064). The HOPS complex facilitates docking and fusion of lysosomes with late endosomes and several other types of vesicles (PubMed:24554766, PubMed:28063257, PubMed:31194677). The HOPS complex is also involved in autophagy and crinophagy (the elimination of unused secretory granules through their fusion with lysosomes) (PubMed:24554766, PubMed:31194677). The HOPS complex mediates autophagocitic flux, probably by binding autophagosome-associated Syx17/syntaxin 17, promoting assembly of the trans-SNARE complex and instigating autophagosome-lysosome fusion (PubMed:24554766, PubMed:28063257). Independent of Syx17/syntaxin 17, HOPS is involved in biosynthetic transport to lysosomes and lysosome-related organelles such as eye-pigment granules (PubMed:10549280, PubMed:24554766, PubMed:31194677). Required for endocytic degradation of boss/bride of sevenless and N/Notch in developing ommatidia (PubMed:24554766). Required for autophagocytosis-dependent remodeling of myofibrils and transverse-tubules (T-tubules) during metamorphosis (PubMed:28063257). In larval neuromuscular junctions, essential for endosomal sorting that traffics old or dysfunctional synaptic vesicle proteins through a degradative endolysosomal route (PubMed:25422373). Required to maintain normal levels of rush, which functions in endosome formation and trafficking (PubMed:22160599)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95R67;Q9W570", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0030897 HOPS complex;GO:0000421 autophagosome membrane;GO:0005768 endosome;GO:0005769 early endosome;GO:0031594 neuromuscular junction", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0048284 organelle fusion;GO:0008057 eye pigment granule organization;GO:0035542 regulation of SNARE complex assembly;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q24314-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24372-1", "uniprot_id": [ { "id": "LACH_DROME", "url": "https://www.uniprot.org/uniprot/Q24372", "type": "external" } ], "mass": 39939.0, "length": 359, "protein_name": "Lachesin", "gene_name": "Lac", "organism": "Fruit fly", "refseq_name": "lachesin", "refseq_ac": [ { "id": "NP_523713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523713", "type": "external" } ], "gene_names_uniprotkb": "Lac; CG12369", "gene_names_refseq": "CG12369; CT24921; Dmel\\CG12369; Lac; bulb; l(2)k11012b; l(2)k11012; lac", "protein_names_uniprotkb": "Lachesin", "protein_names_refseq": "CG12369-PA; Lac-PA; bulbous; lachesin bulbous; lachesin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12369); (R-DME-1474228); (R-DME-1971475); (R-DME-2022928); (R-DME-2024096); (R-DME-216083); (R-DME-3000171); (R-DME-3000178); (R-DME-375165); (R-DME-419037); (R-DME-445144); (R-DME-5673001); (R-DME-9769739); (R-DME-9913351)", "pathway_count": 14, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;14681183;8223276", "class_list": "", "function": "Required for normal tracheal development and maintenance of the trans-epithelial diffusion barrier. Functions as a homophilic cell-adhesion molecule. May play a role in early neuronal differentiation and axon outgrowth., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q86PE5;Q8ML12;Q9V6C2", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection;GO:0005918 septate junction;GO:0098552 side of membrane", "go_biological_process": "GO:0016331 morphogenesis of embryonic epithelium;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0061343 cell adhesion involved in heart morphogenesis;GO:0007424 open tracheal system development;GO:0019991 septate junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q24372-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24400-1", "uniprot_id": [ { "id": "MLP2_DROME", "url": "https://www.uniprot.org/uniprot/Q24400", "type": "external" } ], "mass": 53526.0, "length": 495, "protein_name": "Muscle LIM protein Mlp84B", "gene_name": "Mlp84B", "organism": "Fruit fly", "refseq_name": "muscle LIM protein at 84B, isoform C", "refseq_ac": [ { "id": "NP_001303418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303418", "type": "external" } ], "gene_names_uniprotkb": "Mlp84B; CG1019; LIM3", "gene_names_refseq": "CG1019; DLim-3; DmLIM-3; Dmel\\CG1019; MLP84B; MLP; Mlmu84B; Mlp84B; Mlp84b; Mlp; dMlp84B; mlp84B; mlp", "protein_names_uniprotkb": "Muscle LIM protein Mlp84B", "protein_names_refseq": "CG1019-PC; LIM protein 84B; Mlp84B-PC; Muscle-specific LIM protein at 84B; muscle LIM protein at 84B, isoform C; muscle LIM protein", "tax_id": 7227, "disease": "hypertrophic cardiomyopathy 12 (Disease Ontology:DOID:0110318); dilated cardiomyopathy 1M (Disease Ontology:DOID:0110449); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (dme:Dmel_CG1019)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10397768;10731132;12537572;8794860", "class_list": "", "function": "Plays a role in cell differentiation late in myogenesis. Transcription factor Mef2 is essential for expression., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V2J1;Q9VI62", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008307 structural constituent of muscle;GO:0042805 actinin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030018 Z disc", "go_biological_process": "GO:0007517 muscle organ development;GO:0045214 sarcomere organization;GO:0060537 muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q24400-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24423-1", "uniprot_id": [ { "id": "NOC_DROME", "url": "https://www.uniprot.org/uniprot/Q24423", "type": "external" } ], "mass": 53996.0, "length": 537, "protein_name": "Zinc finger protein Noc", "gene_name": "noc", "organism": "Fruit fly", "refseq_name": "no ocelli, isoform B", "refseq_ac": [ { "id": "NP_001285932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285932", "type": "external" } ], "gene_names_uniprotkb": "noc; BG:DS04641.1; CG4491; Dmel\\CG4491; Dmel_CG4491; NocA; Noc; br22; el; l(2)35Ba; l(2)br22; l35Ba; nocA; noc[A]", "gene_names_refseq": "BG:DS04641.1; CG4491; Dmel\\CG4491; NocA; Noc; br22; el; l(2)35Ba/nocA; l(2)35Ba; l(2)br22; l35Ba; nocA; noc[A]; noc", "protein_names_uniprotkb": "Zinc finger protein Noc; Zinc finger protein NocA", "protein_names_refseq": "CG4491-PB; no ocelli, isoform B; no-ocelli; noc-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4491)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10731132;12117809;12537568;12537569;12537572;12537573;12537574;14757638;16110336;17014842;17569856;17569867;18327897;25589440;26109356;26109357;8289824", "class_list": "", "function": "May negatively regulate Notch-induced cell proliferation in the eye-head primordium. Required for development of the supraesophageal ganglion and ocelli. May act in leg and wing primordia to negatively regulate body-wall specifying genes and thereby promote appendage formation. Plays a role in tracheal development., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0010629 negative regulation of gene expression;GO:0045892 negative regulation of DNA-templated transcription;GO:0007420 brain development;GO:0008056 ocellus development", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q24423-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24558-1", "uniprot_id": [ { "id": "EXO1_DROME", "url": "https://www.uniprot.org/uniprot/Q24558", "type": "external" } ], "mass": 83181.0, "length": 732, "protein_name": "Exonuclease 1", "gene_name": "tos", "organism": "Fruit fly", "refseq_name": "tosca", "refseq_ac": [ { "id": "NP_477145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477145", "type": "external" } ], "gene_names_uniprotkb": "tos; CG10387; exo1", "gene_names_refseq": "CG10387; DmTosca; Dmel\\CG10387; Tosca; tos", "protein_names_uniprotkb": "Exonuclease 1; 3.1.-.-; Exonuclease I; Protein tosca", "protein_names_refseq": "CG10387-PA; tos-PA; tosca", "tax_id": 7227, "disease": "primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (dme:Dmel_CG10387); (R-DME-5358565)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;18327897;8812111", "class_list": "", "function": "5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for DNA mismatch repair (MMR) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9EQW7;Q24557;Q960X5", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0035312 5'-3' DNA exonuclease activity;GO:0045145 single-stranded DNA 5'-3' DNA exonuclease activity;GO:0008409 5'-3' exonuclease activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006310 DNA recombination;GO:0006298 mismatch repair", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q24558-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24564-1", "uniprot_id": [ { "id": "MERH_DROME", "url": "https://www.uniprot.org/uniprot/Q24564", "type": "external" } ], "mass": 74492.0, "length": 635, "protein_name": "Moesin/ezrin/radixin homolog 2", "gene_name": "Mer", "organism": "Fruit fly", "refseq_name": "merlin, isoform B", "refseq_ac": [ { "id": "NP_001285458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285458", "type": "external" } ], "gene_names_uniprotkb": "Mer; BG01543; CG14228; D-Mer; Dmel\\CG14228; Dmel_CG14228; Dmerlin; EMR2; Emr2; MER; NF2; mer", "gene_names_refseq": "BG01543; CG14228; D-Mer; Dmel\\CG14228; Dmerlin; EMR2; Emr2; MER; Mer; NF2; mer", "protein_names_uniprotkb": "Moesin/ezrin/radixin homolog 2; Ezrin-moesin-radixin 2; Merlin; dMerlin", "protein_names_refseq": "BG01543; CG14228-PB; D merlin; Ezrin-moesin-radixin-2; Mer-PB; Merlin/Neurofibromin 2; dmerlin; merlin, isoform B", "tax_id": 7227, "disease": "vestibular schwannomatosis (Disease Ontology:DOID:0111252); otitis media (Disease Ontology:DOID:10754); coloboma (Disease Ontology:DOID:12270); acoustic neuroma (Disease Ontology:DOID:12689); epilepsy (Disease Ontology:DOID:1826); neurilemmoma (Disease Ontology:DOID:3192); meningioma (Disease Ontology:DOID:3565); lung non-small cell carcinoma (Disease Ontology:DOID:3908); renal cell carcinoma (Disease Ontology:DOID:4450); familial meningioma (Disease Ontology:DOID:4586); hepatocellular carcinoma (Disease Ontology:DOID:684); malignant pleural mesothelioma (Disease Ontology:DOID:7474); choledochal cyst (Disease Ontology:DOID:899); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG14228); (R-DME-2029482); (R-DME-5627123)", "pathway_count": 3, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17060498;17569856;17569867;20159598;25589440;26109356;26109357;26954546;8666669", "class_list": "", "function": "Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Mer acts synergistically along with Ex and Kibra to regulate the Hippo signaling pathway., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24054;Q8SWY3", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005178 integrin binding;GO:0042802 identical protein binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0098592 cytoplasmic side of apical plasma membrane;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0046621 negative regulation of organ growth;GO:1902966 positive regulation of protein localization to early endosome;GO:0051307 meiotic chromosome separation;GO:0035330 regulation of hippo signaling", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q24564-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24570-1", "uniprot_id": [ { "id": "GRIM_DROME", "url": "https://www.uniprot.org/uniprot/Q24570", "type": "external" } ], "mass": 15486.0, "length": 138, "protein_name": "Cell death protein Grim", "gene_name": "grim", "organism": "Fruit fly", "refseq_name": "grim", "refseq_ac": [ { "id": "NP_524137", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524137", "type": "external" } ], "gene_names_uniprotkb": "grim; CG4345", "gene_names_refseq": "BcDNA:RE28551; CG4345; Dmel\\CG4345; GRIM; Grim; grim; gri; grm", "protein_names_uniprotkb": "Cell death protein Grim", "protein_names_refseq": "CG4345-PA; grim-PA; grim", "tax_id": 7227, "disease": "Alzheimer's disease 1 (Disease Ontology:DOID:0080348)", "pathway": " (dme:Dmel_CG4345)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;18166655;8698237;9740659", "class_list": "", "function": "Activator of apoptosis, independent of rpr and hid, that acts on the effector Dredd., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VVP6", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005886 plasma membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0051402 neuron apoptotic process;GO:0006915 apoptotic process;GO:0097190 apoptotic signaling pathway;GO:0090200 positive regulation of release of cytochrome c from mitochondria", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q24570-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24574-1", "uniprot_id": [ { "id": "UBPE_DROME", "url": "https://www.uniprot.org/uniprot/Q24574", "type": "external" } ], "mass": 173794.0, "length": 1556, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 47", "gene_name": "Usp47", "organism": "Fruit fly", "refseq_name": "ubiquitin specific protease 47, isoform B", "refseq_ac": [ { "id": "NP_523937", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523937", "type": "external" } ], "gene_names_uniprotkb": "Usp47; CG5486; Ubp64E", "gene_names_refseq": "BcDNA:LD12764; CG5486; D-UBP-64E; D-Ubp-64E; Dmel\\CG5486; E(var)1; E(var)3-64E; E-var(3)64E; Q24574; UBP64E; UBP; USP47; Ubp64E; Ubp64; Upd64E; Usp47; dUBP64; dUSP47; dUbp64; ubp64E; ubp64; usp47", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 47; 3.4.19.12; Ubiquitin thioesterase 47; Ubiquitin-specific-processing protease 47", "protein_names_refseq": "CG5486-PB; Ubiquitin-specific protease 64E; Usp47-PB; ubiquitin specific protease 47, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5486)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10731132;10949024;12537569;12537572;18160715;18327897;26169834;27552662;8816485", "class_list": "", "function": "Ubiquitin-specific protease that deubiquitinates target proteins to regulate different cellular and developmental pathways (PubMed:10949024, PubMed:18160715, PubMed:26169834, PubMed:27552662). Functions downstream of Dsor1/MEK to positively regulate the Ras/MAPK signaling pathway (PubMed:27552662). Likely to modulate the pathway during various cellular and developmental processes including rl/MAPK activation by the receptors InR, Egfr and sevenless/sev (PubMed:27552662). Functions in the post-translational stabilization of rl/MAPK levels in a mechanism that is independent of rl activity and opposes the activity of the E2 enzyme Unc6 and the putative E3 ligases poe, Ufd4 and Kcmf1, which mediate the ubiquitination and proteasomal degradation of rl (PubMed:27552662). During eye development it may also act downstream of rl/MAPK to negatively regulate the Ras/MAPK signaling pathway by stabilizing the transcriptional repressor ttk and consequently inhibiting photoreceptor cell development (PubMed:18160715). This suggests that at least during eye development, it may act in both the positive and negative regulation of the Ras/MAPK signaling pathway to mediate the development of different cell types (PubMed:18160715, PubMed:27552662). Positively regulates border follicle cell migration during oogenesis by mediating the deubiquitination and stabilization of slbo (PubMed:10949024). In the wing disks it positively regulates wg signaling by stabilizing arm (PubMed:26169834). Has an effect on position-effect variegation (PubMed:8816485)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4V1I7;Q95TM9;Q9VRP1", "ec_number_list": [], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0050821 protein stabilization;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q24574-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27297-1", "uniprot_id": [ { "id": "RAD51_DROME", "url": "https://www.uniprot.org/uniprot/Q27297", "type": "external" } ], "mass": 36647.0, "length": 336, "protein_name": "DNA repair protein Rad51 homolog", "gene_name": "spn-A", "organism": "Fruit fly", "refseq_name": "spindle A, isoform A", "refseq_ac": [ { "id": "NP_524583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524583", "type": "external" } ], "gene_names_uniprotkb": "spn-A; CG7948; DMR; Rad51", "gene_names_refseq": "CG7948; D37788; DMR/DroRAD51; DMR1; DMR; Dm Rad51; DmRAD51; DmRad51; Dmel\\CG7948; Dmrad51; RA51_DROME; RA51; RAD51; Rad51dm; Rad51; Spn-A; SpnA; dRad51; dmRAD51; dmrad51; rad51; spn-A; spnA", "protein_names_uniprotkb": "DNA repair protein Rad51 homolog; Protein spindle-A; RecA protein homolog", "protein_names_refseq": "CG7948-PA; Rad51-like; Spindle-A; spindle A, isoform A; spindle A; spn-A-PA", "tax_id": 7227, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); mirror movements 2 (Disease Ontology:DOID:0070637); Fanconi anemia complementation group R (Disease Ontology:DOID:0111090); hypertension (Disease Ontology:DOID:10763); Fanconi anemia (Disease Ontology:DOID:13636); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (dme:Dmel_CG7948); (R-DME-5693616)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;25632158;7857671;8625736;9362456", "class_list": "", "function": "Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (By similarity). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA (By similarity). Spindle genes are required for each of the symmetry-breaking steps that generate polarity during egg axis formation; oocyte positioning at the posterior of the cyst to generate the first AP polarity and inhibition of gurken (grk) signaling to the follicle cell layer to polarize first the AP axis and then DV axis. May have a role in female meiosis (PubMed:8625736, PubMed:9362456)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IGG8;Q8IMJ5;Q9VAA8", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003690 double-stranded DNA binding;GO:0003697 single-stranded DNA binding;GO:0008094 ATP-dependent activity, acting on DNA", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005737 cytoplasm", "go_biological_process": "GO:0006312 mitotic recombination;GO:0009949 polarity specification of anterior/posterior axis;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006302 double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q27297-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27377-1", "uniprot_id": [ { "id": "OB10_DROME", "url": "https://www.uniprot.org/uniprot/Q27377", "type": "external" } ], "mass": 17780.0, "length": 155, "protein_name": "Putative odorant-binding protein A10", "gene_name": "a10", "organism": "Fruit fly", "refseq_name": "antennal protein 10", "refseq_ac": [ { "id": "NP_524121", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524121", "type": "external" } ], "gene_names_uniprotkb": "a10; CG6642; OS-D", "gene_names_refseq": "A10; CG6642; DmelCSP4; Dmel\\CG6642; OS-D/A10; OS-D; Os-D; Phk-1; a10", "protein_names_uniprotkb": "Putative odorant-binding protein A10; Antennal protein 10; OS-D protein", "protein_names_refseq": "CG6642-PA; Pherokine1; a10-PA; antennal protein 10; pherokine 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6642)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;16581978;7545907;8206941", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3LB26;Q9VVD1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q27377-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27421-4", "uniprot_id": [ { "id": "OSP_DROME", "url": "https://www.uniprot.org/uniprot/Q27421", "type": "external" } ], "mass": 175507.0, "length": 1566, "protein_name": "Protein outspread", "gene_name": "osp", "organism": "Fruit fly", "refseq_name": "outspread, isoform C", "refseq_ac": [ { "id": "NP_001137826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137826", "type": "external" } ], "gene_names_uniprotkb": "osp; CG3479", "gene_names_refseq": "BG:DS01486.5; BG:DS01486.7; BG:DS07721.2; CG3479; Dmel\\CG3479; alw; anon-WO02059370.75; l(2)rJ571; osp; v(2)rJ571", "protein_names_uniprotkb": "Protein outspread", "protein_names_refseq": "CG3479-PC; arc-like wing; arclike wing; osp-PC; outspread, isoform C", "tax_id": 7227, "disease": "autosomal recessive nonsyndromic deafness 28 (Disease Ontology:DOID:0110486)", "pathway": " (dme:Dmel_CG3479)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10471707;10731132;12537569;12537572;6410283", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A2VEG2;A9UN92;B7YZW1;E1JHH8;Q24231;Q7KT89;Q8MSX4;Q9VJS4", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0015629 actin cytoskeleton", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q27421-4", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27571-1", "uniprot_id": [ { "id": "NOS_DROME", "url": "https://www.uniprot.org/uniprot/Q27571", "type": "external" } ], "mass": 151715.0, "length": 1349, "protein_name": "Nitric oxide synthase", "gene_name": "Nos", "organism": "Fruit fly", "refseq_name": "nitric oxide synthase, isoform F", "refseq_ac": [ { "id": "NP_001027240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027240", "type": "external" } ], "gene_names_uniprotkb": "Nos; CG6713", "gene_names_refseq": "CG6713; DNOS1; DNOS; Dmel\\CG6713; NOS1; NOS2; NOS; Nos; dNOS4; dNOS; dNos; drNOSoxy; dsNOS; iNOS; iNos; nNOS; nos", "protein_names_uniprotkb": "Nitric oxide synthase; 1.14.13.39; dNOS", "protein_names_refseq": "CG6713-PF; NO synthase; Nos-PF; nitric oixide synthase; nitric oxide synthase, isoform F; nitric oxide synthase; nitric oxidesynthase", "tax_id": 7227, "disease": "lissencephaly (Disease Ontology:DOID:0050453); inflammatory bowel disease (Disease Ontology:DOID:0050589); cardiomyopathy (Disease Ontology:DOID:0050700); obstructive sleep apnea (Disease Ontology:DOID:0050848); limb ischemia (Disease Ontology:DOID:0050852); stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); respiratory allergy (Disease Ontology:DOID:0060496); mucositis (Disease Ontology:DOID:0080178); polycystic kidney disease (Disease Ontology:DOID:0080322); Parkinsonism (Disease Ontology:DOID:0080855); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); asthma, nasal polyps, and aspirin intolerance (Disease Ontology:DOID:0111579); sleeping sickness (Disease Ontology:DOID:10112); osteonecrosis (Disease Ontology:DOID:10159); pleurisy (Disease Ontology:DOID:10247); prostate cancer (Disease Ontology:DOID:10283); asbestosis (Disease Ontology:DOID:10320); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); primary open angle glaucoma (Disease Ontology:DOID:1070); renal hypertension (Disease Ontology:DOID:1073); otitis media (Disease Ontology:DOID:10754); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); essential hypertension (Disease Ontology:DOID:10825); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); sickle cell anemia (Disease Ontology:DOID:10923); intracranial aneurysm (Disease Ontology:DOID:10941); nephritis (Disease Ontology:DOID:10952); gastroschisis (Disease Ontology:DOID:11044); meconium aspiration syndrome (Disease Ontology:DOID:11049); urinary bladder cancer (Disease Ontology:DOID:11054); pneumocystosis (Disease Ontology:DOID:11339); pulmonary edema (Disease Ontology:DOID:11396); familial hyperlipidemia (Disease Ontology:DOID:1168); diabetic angiopathy (Disease Ontology:DOID:11713); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); nephrotic syndrome (Disease Ontology:DOID:1184); anterior ischemic optic neuropathy (Disease Ontology:DOID:12010); allergic disease (Disease Ontology:DOID:1205); Lewy body dementia (Disease Ontology:DOID:12217); primary biliary cholangitis (Disease Ontology:DOID:12236); malaria (Disease Ontology:DOID:12365); vulva cancer (Disease Ontology:DOID:1245); urethral obstruction (Disease Ontology:DOID:12577); hypertrophic pyloric stenosis (Disease Ontology:DOID:12638); leiomyoma (Disease Ontology:DOID:127); telangiectasis (Disease Ontology:DOID:1272); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); dilated cardiomyopathy (Disease Ontology:DOID:12930); alcoholic cardiomyopathy (Disease Ontology:DOID:12935); retinopathy of prematurity (Disease Ontology:DOID:13025); persistent fetal circulation syndrome (Disease Ontology:DOID:13042); dementia (Disease Ontology:DOID:1307); lung cancer (Disease Ontology:DOID:1324); Behcet's disease (Disease Ontology:DOID:13241); pulmonary sarcoidosis (Disease Ontology:DOID:13406); hepatic encephalopathy (Disease Ontology:DOID:13413); angle-closure glaucoma (Disease Ontology:DOID:13550); cholestasis (Disease Ontology:DOID:13580); bladder neck obstruction (Disease Ontology:DOID:13948); interstitial cystitis (Disease Ontology:DOID:13949); anterior uveitis (Disease Ontology:DOID:1407); toxic shock syndrome (Disease Ontology:DOID:14115); Parkinson's disease (Disease Ontology:DOID:14330); hypothyroidism (Disease Ontology:DOID:1459); major depressive disorder (Disease Ontology:DOID:1470); cystic fibrosis (Disease Ontology:DOID:1485); acute chest syndrome (Disease Ontology:DOID:1584); renovascular hypertension (Disease Ontology:DOID:1591); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); epilepsy (Disease Ontology:DOID:1826); impotence (Disease Ontology:DOID:1875); atherosclerosis (Disease Ontology:DOID:1936); hepatitis (Disease Ontology:DOID:2237); transient cerebral ischemia (Disease Ontology:DOID:224); motor neuron disease (Disease Ontology:DOID:231); brain ischemia (Disease Ontology:DOID:2316); colon adenocarcinoma (Disease Ontology:DOID:234); ovarian cancer (Disease Ontology:DOID:2394); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); endometrial carcinoma (Disease Ontology:DOID:2871); pulmonary tuberculosis (Disease Ontology:DOID:2957); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); lymphangioleiomyomatosis (Disease Ontology:DOID:3319); temporal lobe epilepsy (Disease Ontology:DOID:3328); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); macular retinal edema (Disease Ontology:DOID:4449); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); uremia (Disease Ontology:DOID:4676); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); esophagus adenocarcinoma (Disease Ontology:DOID:4914); cholangiocarcinoma (Disease Ontology:DOID:4947); liver cirrhosis (Disease Ontology:DOID:5082); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); paraplegia (Disease Ontology:DOID:607); aortic valve disease (Disease Ontology:DOID:62); migraine (Disease Ontology:DOID:6364); pulmonary hypertension (Disease Ontology:DOID:6432); overnutrition (Disease Ontology:DOID:654); hepatocellular carcinoma (Disease Ontology:DOID:684); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); chronic kidney disease (Disease Ontology:DOID:784); extrinsic allergic alveolitis (Disease Ontology:DOID:841); ileus (Disease Ontology:DOID:8440); retinal degeneration (Disease Ontology:DOID:8466); lung disease (Disease Ontology:DOID:850); vasculitis (Disease Ontology:DOID:865); alcoholic gastritis (Disease Ontology:DOID:8680); diabetic retinopathy (Disease Ontology:DOID:8947); hepatopulmonary syndrome (Disease Ontology:DOID:900); acute myeloid leukemia (Disease Ontology:DOID:9119); achalasia (Disease Ontology:DOID:9164); central sleep apnea (Disease Ontology:DOID:9220); nasopharynx carcinoma (Disease Ontology:DOID:9261); type 2 diabetes mellitus (Disease Ontology:DOID:9352); allergic asthma (Disease Ontology:DOID:9415); pulmonary embolism (Disease Ontology:DOID:9477); pulmonary emphysema (Disease Ontology:DOID:9675); type 1 diabetes mellitus (Disease Ontology:DOID:9744); irritable bowel syndrome (Disease Ontology:DOID:9778); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG6713); (R-DME-1222556); (R-DME-1474151); (R-DME-203615); (R-DME-203754); (R-DME-392154); (R-DME-5218920); (R-DME-5578775); (R-DME-9009391); (R-DME-9033241); (R-DME-9856530)", "pathway_count": 11, "publication_count": 5, "publication_id_list": "10731132;11526108;12537572;12804606;7568075", "class_list": "", "function": "Catalyzes the conversion of L-arginine to L-citrulline producing nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:12804606, PubMed:7568075). Truncated isoforms (isoform 3-isoform 6) are able to form intracellular complexes with the full-length protein and serve as dominant negative inhibitors of the enzyme activity., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 137, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V0K9;A4V0L0;Q4ABG3;Q4ABG4;Q4ABG5;Q4ABG6;Q4ABG7;Q7YU33;Q9U096;Q9VKP8", "ec_number_list": [ { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "2.3.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.-.-", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" } ], "go_molecular_function": "GO:0004517 nitric-oxide synthase activity;GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005777 peroxisome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0008285 negative regulation of cell population proliferation;GO:0032496 response to lipopolysaccharide;GO:0007416 synapse assembly;GO:0007263 nitric oxide mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q27571-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IMX7-1", "uniprot_id": [ { "id": "MIRO_DROME", "url": "https://www.uniprot.org/uniprot/Q8IMX7", "type": "external" } ], "mass": 73776.0, "length": 652, "protein_name": "Mitochondrial Rho GTPase", "gene_name": "Miro", "organism": "Fruit fly", "refseq_name": "mitochondrial Rho, isoform F", "refseq_ac": [ { "id": "NP_001262895", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262895", "type": "external" } ], "gene_names_uniprotkb": "Miro; B682; CG5410; DMiro; DmMiro; Dmel\\CG5410; Dmel_CG5410; Q8IMX7-1; Q8IMX7-2; dMiro; dmiro; miro", "gene_names_refseq": "B682; CG5410; DMiro; DmMiro; Dmel\\CG5410; Miro; Q8IMX7-1; Q8IMX7-2; dMiro; dmiro; miro", "protein_names_uniprotkb": "Mitochondrial Rho GTPase; 3.6.5.-; Miro; dMiro", "protein_names_refseq": "CG5410-PF; Miro-PF; mitochondrial Rho, isoform F; mitochondrial Rho-GTPase", "tax_id": 7227, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); motor neuron disease (Disease Ontology:DOID:231)", "pathway": " (dme:Dmel_CG5410); (R-DME-5689880); (R-DME-9013419); (R-DME-9013425)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;14605208;16055062;16110336;16717129;17569856;17569867;22396657;25589440;26109356;26109357;27716788", "class_list": "", "function": "Mitochondrial GTPase involved in mitochondrial trafficking (PubMed:16055062, PubMed:16717129, PubMed:22396657). Forms an essential protein complex with Milt that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria (PubMed:16717129). Required for axonal transport to synapses within nerve terminals (PubMed:16055062, PubMed:22396657). Required presynaptically but not postsynaptically at neuromuscular junctions (NMJs) (PubMed:16055062). Also involved in the regulation of mitochondrial dynamics by promoting drp1-mediated mitochondrial fission during high calcium conditions, and negatively regulating fission during normal conditions (PubMed:27716788)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IMX6;Q95TT1", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0047497 mitochondrion transport along microtubule;GO:0007005 mitochondrion organization;GO:0010821 regulation of mitochondrion organization;GO:0097345 mitochondrial outer membrane permeabilization;GO:0019896 axonal transport of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8IMX7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VNM1-1", "uniprot_id": [ { "id": "NPFR_DROME", "url": "https://www.uniprot.org/uniprot/Q9VNM1", "type": "external" } ], "mass": 53537.0, "length": 485, "protein_name": "Neuropeptide F receptor", "gene_name": "NPFR", "organism": "Fruit fly", "refseq_name": "neuropeptide F receptor, isoform D", "refseq_ac": [ { "id": "NP_001246947", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246947", "type": "external" } ], "gene_names_uniprotkb": "NPFR; CG1147; DmNPFR1; Dmel\\CG1147; Dmel_CG1147; Drm-NPFR; NPF R; NPF receptor; NPF-R1; NPF-R; NPFR-1; NPFR1; NPFr; RE18294p; anon-WO0131005.3; anon-WO0131005.5; dNPFR1; npfr1; npfr", "gene_names_refseq": "CG1147; DmNPFR1; Dmel\\CG1147; Drm-NPFR; NPF R; NPF receptor; NPF-R1; NPF-R; NPFR-1; NPFR1; NPFR; NPFr; RE18294p; anon-WO0131005.3; anon-WO0131005.5; dNPFR1; npfr1; npfr", "protein_names_uniprotkb": "Neuropeptide F receptor; DmNPFR1", "protein_names_refseq": "CG1147-PD; NPF-receptor; NPFR-PD; dNPF receptor; neuropeptide F receptor 1; neuropeptide F receptor, isoform D; neuropeptide F receptor-1; neuropeptide F receptor", "tax_id": 7227, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); peripheral artery disease (Disease Ontology:DOID:0050830); stroke (Disease Ontology:DOID:0051061); absence epilepsy (Disease Ontology:DOID:0070309); hypertension (Disease Ontology:DOID:10763); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); opiate dependence (Disease Ontology:DOID:2559); lipid metabolism disorder (Disease Ontology:DOID:3146); temporal lobe epilepsy (Disease Ontology:DOID:3328); amphetamine abuse (Disease Ontology:DOID:670); cocaine abuse (Disease Ontology:DOID:809); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dme:Dmel_CG1147)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;11897397;12537568;12537572;12537573;12537574;15677721;16110336;17569856;17569867;19837040;20164335;22422983;25589440;26109356;26109357", "class_list": "", "function": "Receptor for NPF. Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response; coordinates larval foraging and social behavior changes during development. Required in dopaminergic (DA) neurons that innervate the mushroom body for satiety to suppress appetitive memory performance; a key factor in the internal state of hunger in the brain. NPF neurons coordinately modulate diverse sensory and motor neurons important for feeding, flight, and locomotion. NPF/NPFR pathway exerts its suppressive effect on larval aversion to diverse stressful stimuli (chemical stress and noxious heat) through attenuation of TRP channel-induced neuronal excitation. NPF neural signaling system plays a physiological role in acute modulation of alcohol sensitivity in adults, rather than a general response to intoxication by sedative agents. Activation and inhibition of the NPF system reduces and enhances ethanol preference, respectively. Sexual experience, the NPF system activity and ethanol consumption are all linked; sexual deprivation is a major contributor to enhanced ethanol preference., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 15, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D2CFP0;D2CFP1;D2CFP2;D2CFP3;D2CFP4;Q7KFF8;Q8SZ35;Q967T7", "ec_number_list": [], "go_molecular_function": "GO:0008188 neuropeptide receptor activity;GO:0042923 neuropeptide binding;GO:0004983 neuropeptide Y receptor activity;GO:0042263 neuropeptide F receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0042048 olfactory behavior;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0007217 tachykinin receptor signaling pathway;GO:1990834 response to odorant", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9VNM1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VNL3-1", "uniprot_id": [ { "id": "VATF2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VNL3", "type": "external" } ], "mass": 15135.0, "length": 129, "protein_name": "V-type proton ATPase subunit F 2", "gene_name": "Vha14-2", "organism": "Fruit fly", "refseq_name": "vacuolar H[+] ATPase 14kD subunit 2, isoform A", "refseq_ac": [ { "id": "NP_649614", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649614", "type": "external" } ], "gene_names_uniprotkb": "Vha14-2; CG1076; Dmel\\CG1076; Dmel_CG1076; Vha14; vha14-2", "gene_names_refseq": "CG1076; Dmel\\CG1076; Vha14-2; Vha14; vha14-2", "protein_names_uniprotkb": "V-type proton ATPase subunit F 2; V-ATPase subunit F 2; Vacuolar H+ ATPase subunit 14-2; Vacuolar proton pump subunit F 2", "protein_names_refseq": "CG1076-PA; Vha14-2-PA; vacuolar H[+] ATPase 14kD subunit 2, isoform A; vacuolar H[+] ATPase subunit 14-2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1076)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0033180 proton-transporting V-type ATPase, V1 domain;GO:0033176 proton-transporting V-type ATPase complex;GO:0016020 membrane", "go_biological_process": "GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VNL3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VFK6-1", "uniprot_id": [ { "id": "KMT5A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VFK6", "type": "external" } ], "mass": 76493.0, "length": 691, "protein_name": "Histone-lysine N-methyltransferase Set8", "gene_name": "Set8", "organism": "Fruit fly", "refseq_name": "SET domain containing 8, isoform D", "refseq_ac": [ { "id": "NP_001247100", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247100", "type": "external" } ], "gene_names_uniprotkb": "Set8; CG3307; Dmel\\CG3307; Dmel_CG3307; KMT5A; PR-SET7; PR-Set7; PRSET7; PRSet7; Pr-set-7; Pr-set7; PrSet7; SET07; SET8; Set7; dPR-Set7; dSET8; dSet8; l(3)neo41; pr-Set7; pr-set7", "gene_names_refseq": "CG3307; Dmel\\CG3307; PR-SET7; PR-Set7; PR/SET07; PRSET7; PRSet7; Pr-set-7; Pr-set7; PrSet7; SET8; Set7; Set8; dPR-Set7; dSET8; dSet8; l(3)neo41; pr-Set7; pr-set7", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase Set8; 2.1.1.361; Lysine N-methyltransferase 5A; PR/SET domain-containing protein 07; dSET8", "protein_names_refseq": "CG3307-PD; PR/SET domain containing protein 7; SET domain containing 8, isoform D; Set8-PD; pr-set7", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3307); (R-DME-3214841); (R-DME-6804760); (R-DME-9764725)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "10731132;12086618;12121615;12537568;12537569;12537572;12537573;12537574;15681608;16110336;17227890;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, possibly by contributing to the maintenance of proper higher-order structure of DNA and chromosome condensation during mitosis., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q53ZQ8", "ec_number_list": [ { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" } ], "go_molecular_function": "GO:0042799 histone H4K20 methyltransferase activity;GO:0140944 histone H4K20 monomethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005700 polytene chromosome;GO:0005694 chromosome", "go_biological_process": "GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0051301 cell division;GO:0030261 chromosome condensation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9VFK6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q86B87-1", "uniprot_id": [ { "id": "MMD4_DROME", "url": "https://www.uniprot.org/uniprot/Q86B87", "type": "external" } ], "mass": 67171.0, "length": 610, "protein_name": "Modifier of mdg4", "gene_name": "mod(mdg4)", "organism": "Fruit fly", "refseq_name": "modifier of mdg4, isoform AA", "refseq_ac": [ { "id": "NP_001097856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097856", "type": "external" } ], "gene_names_uniprotkb": "mod(mdg4); BcDNA:GH07769; BcDNA:SD03001; CG15500; CG15501; CG15802; CG18151; CG32491; CG7836; CG7859; CG8076; Dmel\\CG32491; Dmel_CG32491; Doom; E(var)129; E(var)3-93D; E(var)93D; E-(var)3-93D; E-var(3)1; E-var(3)3; LBC; MOD(MDG4)56.3; MOD(MDG4); MOD2.2; Mod(mdg 4)67.2; Mod(mdg 4); Mod(mdg)4; Mod(mdg4)-67.2; Mod(mdg4)2.2; Mod(mdg4)67.2; Mod(mdg4); Mod2.2; Mod67.2; Mod[mdg4]; R5_3R:17176815..17177103; bpd; doom; l(3)03852; l(3)L3101; l(3)j2B7; mdg4; mmd4; mnm; mnn; mod (mdg4); mod(gypsy); mod(mdg)4; mod(mdg-4); mod(mdg4)-58.8; mod(mdg4)-67.2; mod(mdg4)67.2; mod(mdg4; mod-mdg4; mod2.2; modMDG4; mod[mdg4]; mod; pf-2", "gene_names_refseq": "BcDNA:GH07769; BcDNA:SD03001; CG15500; CG15501; CG15802; CG18151; CG32491; CG7836; CG7859; CG8076; Dmel\\CG32491; Doom; E(var)129; E(var)3-93D; E(var)93D; E-(var)3-93D; E-var(3)1; E-var(3)3; LBC; MOD(MDG4)56.3; MOD(MDG4); MOD2.2; Mod(mdg 4)67.2; Mod(mdg 4); Mod(mdg)4; Mod(mdg4)-67.2; Mod(mdg4)2.2; Mod(mdg4)67.2; Mod(mdg4); Mod2.2; Mod67.2; Mod[mdg4]; R5_3R:17176815..17177103; bpd; doom; l(3)03852; l(3)L3101; l(3)j2B7; mdg4; mmd4; mnm; mnn; mod (mdg4); mod(gypsy); mod(mdg)4; mod(mdg-4); mod(mdg4)-58.8; mod(mdg4)-67.2; mod(mdg4)67.2; mod(mdg4); mod(mdg4; mod-mdg4; mod2.2; modMDG4; mod[mdg4]; mod; pf-2", "protein_names_uniprotkb": "Modifier of mdg4", "protein_names_refseq": "CG32491-PAA; Mod(mdg4)-67.2; Modifier67.2; branch point disrupted; enhancer of variegation 93D; late boundary complex; mod(mdg4 isoform N); mod(mdg4)-PAA; modifier mdg4; modifier of (mdg4) 67.2; modifier of mdg 4 67.2; modifier of mdg4 67.2; modifier of mdg4 in meiosis; modifier of mdg4, isoform AA; modifier of mdg4; modifier of midget4", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32491)", "pathway_count": 1, "publication_count": 32, "publication_id_list": "10363916;10731132;10790390;11024164;11106742;11350941;11416154;11493677;11604507;11779804;12537568;12537572;12537573;12537574;15465920;15574329;16110336;16209949;16286005;17569856;17569867;18327897;21304601;25589440;26109356;26109357;7664338;7761470;8248257;8852842;9111355;9491892", "class_list": "", "function": "Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein may control the nature of the repressive effect of su(Hw): in the absence of mod(mdg4) protein, su(Hw) exerts a bidirectional silencing effect, whereas in the presence of mod(mdg4), the silencing effect is unidirectional. Isoform H is specifically required to maintain the pairing of achiasmate homologs in male meiosis I which is mediated by the rDNA repeats on the achiasmate X-Y bivalents. Isoform H also plays a role in apoptotic regulatory pathways., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1A725;A8JR64;A8JR66;P91932;Q24099;Q24100;Q24101;Q24482;Q24483;Q86B84;Q86B85;Q86B86;Q8IN28;Q8IN29;Q8IN30;Q8IN31;Q8IN32;Q8IN33;Q8IN34;Q8WTI9;Q8WTJ0;Q8WTJ1;Q95R78;Q95ZF4;Q95ZF5;Q95ZF6;Q95ZF7;Q95ZF8;Q9N6U6;Q9N6U7;Q9N6U8;Q9N6U9;Q9N6V0;Q9N6V1;Q9N6V2;Q9N6V3;Q9N6V4;Q9N6V5;Q9N6V6;Q9N6V7;Q9N6V8;Q9N6V9;Q9N6W0;Q9N6W1;Q9N6W2;Q9N6W3;Q9N6W4;Q9N6W5;Q9VDA9;Q9VDB2;Q9VDB3;Q9VDB4;Q9VDB5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0031208 POZ domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0005700 polytene chromosome;GO:0005704 polytene chromosome band", "go_biological_process": "GO:0007060 male meiosis chromosome segregation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 3.3, "record_id": "Q86B87-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27601-1", "uniprot_id": [ { "id": "PUR1_DROME", "url": "https://www.uniprot.org/uniprot/Q27601", "type": "external" } ], "mass": 59520.0, "length": 546, "protein_name": "Amidophosphoribosyltransferase", "gene_name": "Prat", "organism": "Fruit fly", "refseq_name": "phosphoribosylamidotransferase, isoform B", "refseq_ac": [ { "id": "NP_001246972", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246972", "type": "external" } ], "gene_names_uniprotkb": "Prat; CG2867; DmPrat; Dmel\\CG2867; Dmel_CG2867", "gene_names_refseq": "CG2867; DmPrat; Dmel\\CG2867; Prat", "protein_names_uniprotkb": "Amidophosphoribosyltransferase; 2.4.2.14; ATase; GPAT; Glutamine phosphoribosylpyrophosphate amidotransferase; PRAT; Phosphoribosylamidotransferase", "protein_names_refseq": "CG2867-PB; Prat-PB; phosphoribosylamidotransferase, isoform B; transcript D", "tax_id": 7227, "disease": "renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dme:Dmel_CG2867); (R-DME-73817)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;8150282", "class_list": "", "function": "Involved in the first step (and regulatory point) of the de novo biosynthesis of purine nucleotides, where it catalyzes the transfer of glutamine amide to 5-phospho-alpha-D-ribose 1-diphosphate., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8T009;Q9VHY4", "ec_number_list": [ { "id": "2.4.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.14", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0004044 amidophosphoribosyltransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0040016 embryonic cleavage;GO:0048477 oogenesis;GO:0008340 determination of adult lifespan;GO:0009113 purine nucleobase biosynthetic process;GO:0006164 purine nucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q27601-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VB70-1", "uniprot_id": [ { "id": "LST2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VB70", "type": "external" } ], "mass": 108800.0, "length": 989, "protein_name": "Lateral signaling target protein 2 homolog", "gene_name": "blr2", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001097943", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097943", "type": "external" } ], "gene_names_uniprotkb": "blr2; CG6051; Dmel\\CG6051; Dmel_CG6051", "gene_names_refseq": "CG6051; Dmel\\CG6051; blr2", "protein_names_uniprotkb": "Lateral signaling target protein 2 homolog", "protein_names_refseq": "CG6051-PB; blade runner 2; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6051)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Negative regulator of epidermal growth factor receptor (EGFR) signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q86P84;Q8T0G9", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0004721 phosphoprotein phosphatase activity;GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0031901 early endosome membrane;GO:0016020 membrane", "go_biological_process": "GO:0046474 glycerophospholipid biosynthetic process;GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway;GO:0046856 phosphatidylinositol dephosphorylation;GO:0061952 midbody abscission", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VB70-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q960E8-1", "uniprot_id": [ { "id": "TF2H1_DROME", "url": "https://www.uniprot.org/uniprot/Q960E8", "type": "external" } ], "mass": 66339.0, "length": 585, "protein_name": "General transcription factor IIH subunit 1", "gene_name": "Tfb1", "organism": "Fruit fly", "refseq_name": "transcription factor B1, isoform D", "refseq_ac": [ { "id": "NP_001246321", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246321", "type": "external" } ], "gene_names_uniprotkb": "Tfb1; CG8151; Dmel\\CG8151; Dmel_CG8151; Dmp62; TFB1; TfBl; l(2)06949; l(2)06950; p62", "gene_names_refseq": "CG8151; Dmel\\CG8151; Dmp62; TFB1; TfBl; Tfb1; l(2)06949; l(2)06950; p62", "protein_names_uniprotkb": "General transcription factor IIH subunit 1; TFIIH basal transcription factor complex subunit 1", "protein_names_refseq": "CG8151-PD; TFB1 ortholog; TfBl; Tfb1-PD; transcription factor B1, isoform D", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8151); (R-DME-112382); (R-DME-113418); (R-DME-5696395); (R-DME-5696400); (R-DME-674695); (R-DME-6781823); (R-DME-6782135); (R-DME-6782210); (R-DME-6796648); (R-DME-72086); (R-DME-73772); (R-DME-73776); (R-DME-73779); (R-DME-75953); (R-DME-75955); (R-DME-76042); (R-DME-77075)", "pathway_count": 18, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZH0;Q0E978", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005675 transcription factor TFIIH holo complex;GO:0000439 transcription factor TFIIH core complex", "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:0006281 DNA repair;GO:0009411 response to UV;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q960E8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VBG6-1", "uniprot_id": [ { "id": "HGH1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VBG6", "type": "external" } ], "mass": 41799.0, "length": 369, "protein_name": "Co-chaperone protein HGH1 homolog", "gene_name": "Dmel\\CG6073", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001247313", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247313", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG6073; CG6073; Dmel_CG6073", "gene_names_refseq": "CG6073; Dmel\\CG6073", "protein_names_uniprotkb": "Co-chaperone protein HGH1 homolog", "protein_names_refseq": "CG6073-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6073)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Co-chaperone involved in the folding of nascent eukaryotic elongation factor eEF2, an essential component of the translation machinery. Recognizes a non-native conformation in the central domain of eEF2 and recruits the chaperonin-containing T-complex (TRiC) to the C-terminal region of the nascent polypeptide, preventing unproductive interactions and promoting efficient folding of the N-terminal GTPase domain. May also assist in eEF2 maturation by recruiting the molecular chaperone Hsp90., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95S85", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VBG6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9NKV0-1", "uniprot_id": [ { "id": "MLF_DROME", "url": "https://www.uniprot.org/uniprot/Q9NKV0", "type": "external" } ], "mass": 41377.0, "length": 376, "protein_name": "Myeloid leukemia factor", "gene_name": "Mlf", "organism": "Fruit fly", "refseq_name": "Myelodysplasia/myeloid leukemia factor, isoform A", "refseq_ac": [ { "id": "NP_523753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523753", "type": "external" } ], "gene_names_uniprotkb": "Mlf; BcDNA:SD18148; CG8295; Dmel\\CG8295; Dmel_CG8295; MLF; dMLF; dmlf; mlf", "gene_names_refseq": "BcDNA:SD18148; CG8295; Dmel\\CG8295; MLF; Mlf; dMLF; dmlf; mlf", "protein_names_uniprotkb": "Myeloid leukemia factor; Myelodysplasia-myeloid leukemia factor; dMLF", "protein_names_refseq": "CG8295-PA; Mlf-PA; Myelodysplasia/myeloid leukemia factor, isoform A; drosophila myeloid leukemia factor", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8295)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;11137299;12354791;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A1ZA61;A1ZA62;Q540Y3;Q8IG90;Q95P43;Q9V7G3", "ec_number_list": [], "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0005705 polytene chromosome interband", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0050821 protein stabilization;GO:0042691 positive regulation of crystal cell differentiation;GO:2000495 regulation of cell proliferation involved in compound eye morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9NKV0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V8F3-1", "uniprot_id": [ { "id": "GSKIP_DROME", "url": "https://www.uniprot.org/uniprot/Q9V8F3", "type": "external" } ], "mass": 13534.0, "length": 119, "protein_name": "Protein GSKIP homolog", "gene_name": "Dmel\\CG14505", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001036558", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036558", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG14505; CG14505; Dmel_CG14505", "gene_names_refseq": "CG14505; Dmel\\CG14505", "protein_names_uniprotkb": "Protein GSKIP homolog", "protein_names_refseq": "CG14505-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14505)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051018 protein kinase A binding;GO:0019207 kinase regulator activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0060828 regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9V8F3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9N2P6-1", "uniprot_id": [ { "id": "VEPD_DROME", "url": "https://www.uniprot.org/uniprot/Q9N2P6", "type": "external" } ], "mass": 9605.0, "length": 81, "protein_name": "Ventrally expressed gene D protein", "gene_name": "VepD", "organism": "Fruit fly", "refseq_name": "Ventrally-expressed protein D, isoform B", "refseq_ac": [ { "id": "NP_001246459", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246459", "type": "external" } ], "gene_names_uniprotkb": "VepD; CG33200; Dmel\\CG33200; Dmel_CG33200; D; anon-EST:CL57; ventrally-expressed-protein-D; vepD", "gene_names_refseq": "CG33200; Dmel\\CG33200; D; VepD; anon-EST:CL57; ventrally-expressed-protein-D; vepD", "protein_names_uniprotkb": "Ventrally expressed gene D protein", "protein_names_refseq": "CG33200-PB; Ventrally-expressed protein D, isoform B; VepD-PB; ventrally expressed protein-D; ventrally-expressed-protein-D", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33200)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8816799", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9N2P6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9BJZ5-1", "uniprot_id": [ { "id": "FUSIL_DROME", "url": "https://www.uniprot.org/uniprot/Q9BJZ5", "type": "external" } ], "mass": 102743.0, "length": 967, "protein_name": "RNA-binding protein fusilli", "gene_name": "fus", "organism": "Fruit fly", "refseq_name": "fusilli, isoform D", "refseq_ac": [ { "id": "NP_524691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524691", "type": "external" } ], "gene_names_uniprotkb": "fus; CG8205; Dmel\\CG8205; Dmel_CG8205; E(cact[E10])7; FUS; Fus; cg8205", "gene_names_refseq": "CG8205; Dmel\\CG8205; E(cact[E10])7; FUS; Fus; cg8205; fus", "protein_names_uniprotkb": "RNA-binding protein fusilli", "protein_names_refseq": "CG8205-PD; enhancer of cactus[E10], number 7; fus-PD; fusilli, isoform D; fusilli", "tax_id": 7227, "disease": "autosomal recessive nonsyndromic deafness 109 (Disease Ontology:DOID:0111639)", "pathway": " (dme:Dmel_CG8205)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;11133153;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;19285943;25589440;26109356;26109357;33925313", "class_list": "", "function": "mRNA splicing factor that regulates alternative splicing od specific genes. Has a maternal role in embryonic dorsal-ventral patterning; such role is probably indirect and due to its function as mRNA splicing factor regulator., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1ZA30;A1ZA31;Q1EBX1;Q7JR39;Q960H4", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9BJZ5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q95RW8-1", "uniprot_id": [ { "id": "OPTIX_DROME", "url": "https://www.uniprot.org/uniprot/Q95RW8", "type": "external" } ], "mass": 52419.0, "length": 487, "protein_name": "Protein Optix", "gene_name": "Optix", "organism": "Fruit fly", "refseq_name": "optix, isoform A", "refseq_ac": [ { "id": "NP_524695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524695", "type": "external" } ], "gene_names_uniprotkb": "Optix; CG18455; D-Six3; Dmel\\CG18455; Dmel_CG18455; Dsix3; OPTIX; Six3; anon-WO0153538.79; optix; opt; opx; six3", "gene_names_refseq": "CG18455; D-Six3; Dmel\\CG18455; Dsix3; OPTIX; Optix; Six3; anon-WO0153538.79; optix; opt; opx; six3", "protein_names_uniprotkb": "Protein Optix; D-Six3; Homeobox protein SIX3", "protein_names_refseq": "CG18455-PA; Optix-PA; optix, isoform A; optix", "tax_id": 7227, "disease": "optic disc anomalies with retinal and/or macular dystrophy (Disease Ontology:DOID:0080635); holoprosencephaly 2 (Disease Ontology:DOID:0110872); holoprosencephaly (Disease Ontology:DOID:4621)", "pathway": " (dme:Dmel_CG18455)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10381573;10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;9724757", "class_list": "", "function": "May be involved in head or eye development; development of the clypeolabrum and several head sensory organs., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O76291;Q8MKN3;Q9UA64;Q9V355", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0048749 compound eye development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0048813 dendrite morphogenesis;GO:0001745 compound eye morphogenesis;GO:0001751 compound eye photoreceptor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q95RW8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V8P9-1", "uniprot_id": [ { "id": "TOPRS_DROME", "url": "https://www.uniprot.org/uniprot/Q9V8P9", "type": "external" } ], "mass": 113313.0, "length": 1038, "protein_name": "E3 ubiquitin-protein ligase Topors", "gene_name": "Topors", "organism": "Fruit fly", "refseq_name": "topoisomerase I-interacting protein, isoform B", "refseq_ac": [ { "id": "NP_001261083", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261083", "type": "external" } ], "gene_names_uniprotkb": "Topors; CG15104; Dmel\\CG15104; Dmel_CG15104; TOPORS; dTopors; dtopors; nbl", "gene_names_refseq": "CG15104; Dmel\\CG15104; TOPORS; Topors; dTopors; dtopors; nbl", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Topors; 2.3.2.27; RING-type E3 ubiquitin transferase Topors; SUMO1-protein E3 ligase Topors; Topoisomerase I-binding RING finger protein; Topoisomerase I-binding arginine/serine-rich protein; dTopors", "protein_names_refseq": "CG15104-PB; Topors-PB; nuclear blebber; topoisomerase I-interacting protein, isoform B", "tax_id": 7227, "disease": "retinitis pigmentosa 31 (Disease Ontology:DOID:0110391)", "pathway": " (dme:Dmel_CG15104)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;14871887;16110336;16209949;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Functions as a ubiquitin-protein E3 ligase. Negatively regulates the transcriptional repressor hairy/hry by promoting its ubiquitination and subsequent degradation. Also directs the nuclear organization of the gypsy chromatin insulator. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them, and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may require the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein may promote formation of nuclear insulator bodies by recruiting individual insulator complexes to the nuclear lamina., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0005521 lamin binding;GO:0019789 SUMO transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005652 nuclear lamina;GO:0005700 polytene chromosome", "go_biological_process": "GO:0007060 male meiosis chromosome segregation;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9V8P9-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V359-1", "uniprot_id": [ { "id": "VPS28_DROME", "url": "https://www.uniprot.org/uniprot/Q9V359", "type": "external" } ], "mass": 24512.0, "length": 210, "protein_name": "Vacuolar protein sorting-associated protein 28 homolog", "gene_name": "Vps28", "organism": "Fruit fly", "refseq_name": "vacuolar protein sorting 28, isoform B", "refseq_ac": [ { "id": "NP_001260796", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260796", "type": "external" } ], "gene_names_uniprotkb": "Vps28; CG12770; DmVps28; Dmel\\CG12770; Dmel_CG12770; Dvps28; ESCRT-II; ESCRT-I; dVps28; dvps28; l(2)k16503; vps28", "gene_names_refseq": "CG12770; DmVps28; Dmel\\CG12770; Dvps28; ESCRT-II; ESCRT-I; Vps28; dVps28; dvps28; l(2)k16503; vps28", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 28 homolog; ESCRT-I complex subunit VPS28", "protein_names_refseq": "CG12770-PB; Vps28-PB; vacuolar protein sorting 28, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12770); (R-DME-917729)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15728719;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process., [UniProtKB, UniProtKB]; Component of the ESCRT-I complex, a regulator of vesicular trafficking process., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0010008 endosome membrane;GO:0000813 ESCRT I complex", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0097352 autophagosome maturation;GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0016322 neuron remodeling;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9V359-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7PLI2-1", "uniprot_id": [ { "id": "NIPB_DROME", "url": "https://www.uniprot.org/uniprot/Q7PLI2", "type": "external" } ], "mass": 236729.0, "length": 2077, "protein_name": "Nipped-B protein", "gene_name": "Nipped-B", "organism": "Fruit fly", "refseq_name": "Nipped-B, isoform F", "refseq_ac": [ { "id": "NP_001036451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036451", "type": "external" } ], "gene_names_uniprotkb": "Nipped-B; CG17704; CG40281; Dmel\\CG17704; Dmel_CG17704; NIPPED-B; Nip-B; NipB; l(2)02047; nipped-B", "gene_names_refseq": "CG17704; CG40281; Dmel\\CG17704; NIPPED-B; Nip-B; NipB; Nipped-B; l(2)02047; nipped-B", "protein_names_uniprotkb": "Nipped-B protein; SCC2 homolog", "protein_names_refseq": "CG17704-PF; NipB; Nipped-B, isoform F; Nipped-B-PF; NippedB; nipped B", "tax_id": 7227, "disease": "Cornelia de Lange syndrome 1 (Disease Ontology:DOID:0080505); Cornelia de Lange syndrome (Disease Ontology:DOID:11725); cancer (Disease Ontology:DOID:162)", "pathway": " (dme:Dmel_CG17704); (R-DME-2470946)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10353901;10731132;12537568;12537572;12537573;12537574;15060134;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Plays a structural role in chromatin. Involved in sister chromatid cohesion, probably via an interaction with the cohesin complex. Participates in the transcriptional activation mediated by remote enhancers on genes such as cut and Ubx, possibly by alleviating the cohesin-mediated blocking of enhancer-promoter communication., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UZ37;Q058T3;Q058T4;Q7PLI3;Q9XYM2", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0061775 cohesin loader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000791 euchromatin;GO:0032116 SMC loading complex;GO:0090694 Scc2-Scc4 cohesin loading complex;GO:0005700 polytene chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007612 learning;GO:0010628 positive regulation of gene expression;GO:0006355 regulation of DNA-templated transcription;GO:0007614 short-term memory", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q7PLI2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VN12-1", "uniprot_id": [ { "id": "NCKXH_DROME", "url": "https://www.uniprot.org/uniprot/Q9VN12", "type": "external" } ], "mass": 69570.0, "length": 633, "protein_name": "Probable sodium/potassium/calcium exchanger CG1090", "gene_name": "Dmel\\CG1090", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform I", "refseq_ac": [ { "id": "NP_001262252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262252", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG1090; CG1090; Dmel_CG1090", "gene_names_refseq": "CG1090; Dmel\\CG1090", "protein_names_uniprotkb": "Probable sodium/potassium/calcium exchanger CG1090; Na(+)/K(+)/Ca(2+)-exchange protein CG1090", "protein_names_refseq": "CG1090-PI; uncharacterized protein, isoform I", "tax_id": 7227, "disease": "ocular albinism 1 (Disease Ontology:DOID:0050633); oculocutaneous albinism type VI (Disease Ontology:DOID:0080614)", "pathway": " (dme:Dmel_CG1090); (R-DME-425561)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17018572;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "May function in the removal and maintenance of calcium homeostasis. Transports one Ca(2+) and 1 K(+) in exchange for 4 Na(+) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IPM4;Q8SXA2", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0015293 symporter activity;GO:0008273 calcium, potassium:sodium antiporter activity;GO:0015297 antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0070588 calcium ion transmembrane transport;GO:0006814 sodium ion transport;GO:0006813 potassium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VN12-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VHB4-1", "uniprot_id": [ { "id": "Q9VHB4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VHB4", "type": "external" } ], "mass": 95730.0, "length": 831, "protein_name": "ATPase AAA-type core domain-containing protein", "gene_name": "Dmel\\CG16789", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": [ { "id": "NP_649910", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649910", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG16789; CG16789; Dmel_CG16789", "gene_names_refseq": "CG16789; Dmel\\CG16789", "protein_names_uniprotkb": "ATPase AAA-type core domain-containing protein", "protein_names_refseq": "CG16789-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG16789)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VHB4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VGE8-1", "uniprot_id": [ { "id": "TACHY_DROME", "url": "https://www.uniprot.org/uniprot/Q9VGE8", "type": "external" } ], "mass": 31678.0, "length": 289, "protein_name": "Tachykinins", "gene_name": "Tk", "organism": "Fruit fly", "refseq_name": "tachykinin, isoform A", "refseq_ac": [ { "id": "NP_650141", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650141", "type": "external" } ], "gene_names_uniprotkb": "Tk; CG14734; DTK-1; DTK-2; DTK-3; DTK-4; DTK-5; DTK-6; DTK1; DTK; DTk; DmTK6; Dmel\\CG14734; Dmel_CG14734; Drm-TK-1; Drm-TK-2; Drm-TK-3; Drm-TK-4; Drm-TK-5; Drm-TK-6; Drm-TK; Dtk; TAP-5; TK-1; TK; Tachykinin 1; Tachykinin 2; Tachykinin 4; Tachykinin 5; Tyk; dTK; dtk", "gene_names_refseq": "CG14734; DTK-1; DTK-2; DTK-3; DTK-4; DTK-5; DTK-6; DTK1; DTK; DTk; DmTK6; Dmel\\CG14734; Drm-TK-1; Drm-TK-2; Drm-TK-3; Drm-TK-4; Drm-TK-5; Drm-TK-6; Drm-TK; Dtk; TAP-5; TK-1; TK; Tachykinin 1; Tachykinin 2; Tachykinin 4; Tachykinin 5; Tk; Tyk; dTK; dtk", "protein_names_uniprotkb": "Tachykinins; AALSDSYDLRGKQQRFADFNSKFVAVR-amide; APLAFVGLR-amide; APNGFLGMR-amide; APTGFTGMR-amide; APTSSFIGMR-amide; APVNSFVGMR-amide; Brain peptide DVSHQHY; Brain peptide PALLAGDDDAEADEATELQQ; Brain peptide SDLEGNGVGIGDDHEQALVHPWLYLWGE; DEEHDTSEGNWLGSGPDPLDYADEEADSSYAEN-amide; FIPINNRLSDVLQSLEEERLRDSLLQDFFDRVAGRDGSAV-amide; dTk", "protein_names_refseq": "CG14734-PA; Tachykinin-related; Tk-PA; neurokinin; preprotachykinin; tachykinin, isoform A; tachykinin-1; tachykinin-3; tachykinin-6; tachykinin-like peptide", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14734)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;10801863;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;21214272;25589440;26083710;26109356;26109357", "class_list": "", "function": "Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Stimulates gut muscle contractions (PubMed:10801863). Required for the response to the male sex pheromone CH503 which is transferred from males to females during mating and inhibits courtship behavior by other males (PubMed:26083710). The Gr68a gustatory receptor is required for detection of the pheromone and Gr68a-expressing neurons in the male foreleg relay signals to the suboesophageal zone (SEZ) which leads to courtship suppression through release of tachykinin from a cluster of 8-10 neurons in the SEZ (PubMed:26083710)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5RJL9;Q8SZ21;Q9NBJ5", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002121 inter-male aggressive behavior;GO:0060450 positive regulation of hindgut contraction;GO:0006629 lipid metabolic process;GO:0007218 neuropeptide signaling pathway;GO:0007628 adult walking behavior", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VGE8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6AWG9-1", "uniprot_id": [ { "id": "Y5098_DROME", "url": "https://www.uniprot.org/uniprot/Q6AWG9", "type": "external" } ], "mass": 133869.0, "length": 1238, "protein_name": "Uncharacterized protein CG5098", "gene_name": "Dmel\\CG5098", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001097363", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097363", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG5098; CG5098; Dmel_CG5098", "gene_names_refseq": "CG5098; Dmel\\CG5098", "protein_names_uniprotkb": "Uncharacterized protein CG5098", "protein_names_refseq": "CG5098-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); Phelan-McDermid syndrome (Disease Ontology:DOID:0080354)", "pathway": " (dme:Dmel_CG5098)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A8DYH9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q6AWG9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VFI9-1", "uniprot_id": [ { "id": "PDE6_DROME", "url": "https://www.uniprot.org/uniprot/Q9VFI9", "type": "external" } ], "mass": 124325.0, "length": 1118, "protein_name": "cGMP-specific 3',5'-cyclic phosphodiesterase", "gene_name": "Pde6", "organism": "Fruit fly", "refseq_name": "phosphodiesterase 6, isoform D", "refseq_ac": [ { "id": "NP_001287327", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287327", "type": "external" } ], "gene_names_uniprotkb": "Pde6; 6; CG8279; DmPDE6; Dmel\\CG8279; Dmel_CG8279; PDE6", "gene_names_refseq": "CG8279; DmPDE5/6; DmPDE6; Dmel\\CG8279; PDE5/6; PDE6; Pde6", "protein_names_uniprotkb": "cGMP-specific 3',5'-cyclic phosphodiesterase; 3.1.4.35; DmPDE5/6; DmPDE6", "protein_names_refseq": "CG8279-PD; Pde6-PD; phosphodiesterase 6, isoform D", "tax_id": 7227, "disease": "cone-rod dystrophy (Disease Ontology:DOID:0050572); retinitis pigmentosa 40 (Disease Ontology:DOID:0110375); retinitis pigmentosa 43 (Disease Ontology:DOID:0110379); congenital stationary night blindness autosomal dominant 2 (Disease Ontology:DOID:0110863); retinitis pigmentosa (Disease Ontology:DOID:10584); achromatopsia (Disease Ontology:DOID:13911); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (dme:Dmel_CG8279)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15673286;16110336;16232123;17569856;17569867;18503409;25589440;26109356;26109357", "class_list": "", "function": "Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes (PubMed:15673286). Has cAMP phosphodiesterase activity in vitro but not in vivo (PubMed:15673286). Has a role regulating cGMP transport in Malpighian tubule principal cells (PubMed:16232123)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q95TW8", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0046068 cGMP metabolic process;GO:0032240 negative regulation of nucleobase-containing compound transport;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VFI9-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VFJ3-1", "uniprot_id": [ { "id": "HTRA2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VFJ3", "type": "external" } ], "mass": 46000.0, "length": 422, "protein_name": "Serine protease HTRA2, mitochondrial", "gene_name": "HtrA2", "organism": "Fruit fly", "refseq_name": "HTRA2-related serine protease, isoform B", "refseq_ac": [ { "id": "NP_001262565", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262565", "type": "external" } ], "gene_names_uniprotkb": "HtrA2; CG8464; DmHtrA2; Dmel\\CG8464; Dmel_CG8464; HTRA2; HtrA2; Omi; dOmi; domi; htrA2; omi", "gene_names_refseq": "CG8464; DmHtrA2; Dmel\\CG8464; Dmel_CG8464; HTRA2; HtrA2/Omi; HtrA2; Omi/HtrA2; Omi; dOmi; domi; htrA2/omi; htrA2; omi", "protein_names_uniprotkb": "Serine protease HTRA2, mitochondrial; 3.4.21.108; DmHtrA2; High temperature requirement protein A2; HtrA2; Omi stress-regulated endoprotease; dOmi", "protein_names_refseq": "CG8464-PB; HTRA2-related serine protease, isoform B; HtrA2-PB; high temperature requirement A2; serine protease HTRA2", "tax_id": 7227, "disease": "vitelliform macular dystrophy (Disease Ontology:DOID:0050661); patterned macular dystrophy (Disease Ontology:DOID:0060863); autosomal recessive cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 2 (Disease Ontology:DOID:0061228); 3-methylglutaconic aciduria type 8 (Disease Ontology:DOID:0070000); age related macular degeneration 7 (Disease Ontology:DOID:0110019); autosomal dominant cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 2 (Disease Ontology:DOID:0111036); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); age related macular degeneration (Disease Ontology:DOID:10871); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); esophageal carcinoma (Disease Ontology:DOID:1107); asphyxia neonatorum (Disease Ontology:DOID:11088); cryptorchidism (Disease Ontology:DOID:11383); endometrial cancer (Disease Ontology:DOID:1380); Parkinson's disease (Disease Ontology:DOID:14330); malignant mesothelioma (Disease Ontology:DOID:1790); status epilepticus (Disease Ontology:DOID:1824); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); motor neuron disease (Disease Ontology:DOID:231); ovarian cancer (Disease Ontology:DOID:2394); middle cerebral artery infarction (Disease Ontology:DOID:3525); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684); ulcerative colitis (Disease Ontology:DOID:8577); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351)", "pathway": " (dme:Dmel_CG8464); (R-DME-9837999)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17397804;17557079;17569856;17569867;18259196;19048081;25589440;26109356;26109357;40245499", "class_list": "", "function": "Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th/Diap1 by directly inducing the degradation of th/Diap1., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 31, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.108", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.108", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0017171 serine hydrolase activity;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol;GO:0031966 mitochondrial membrane;GO:0016006 Nebenkern", "go_biological_process": "GO:0006508 proteolysis;GO:0007283 spermatogenesis;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9VFJ3-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9I7K0-1", "uniprot_id": [ { "id": "JUPIT_DROME", "url": "https://www.uniprot.org/uniprot/Q9I7K0", "type": "external" } ], "mass": 22319.0, "length": 208, "protein_name": "Microtubule-associated protein Jupiter", "gene_name": "Jupiter", "organism": "Fruit fly", "refseq_name": "jupiter, isoform D", "refseq_ac": [ { "id": "NP_731595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_731595", "type": "external" } ], "gene_names_uniprotkb": "Jupiter; BEST:LP05168; BcDNA:GH06373; BcDNA:LD21358; BcDNA:LD43690; BcDNA:RH53211; CG17238; CG18762; CG18763; CG31363; Dmel\\CG31363; Dmel_CG31363; G147; anon-EST:Liang-1.76; anon-WO0140519.173; clone 1.76; jupiter; jup", "gene_names_refseq": "BEST:LP05168; BcDNA:GH06373; BcDNA:LD21358; BcDNA:LD43690; BcDNA:RH53211; CG17238; CG18762; CG18763; CG31363; Dmel\\CG31363; Jupiter; anon-EST:Liang-1.76; anon-WO0140519.173; clone 1.76; jupiter; jup", "protein_names_uniprotkb": "Microtubule-associated protein Jupiter", "protein_names_refseq": "CG31363-PD; Jupiter-PD; jupiter, isoform D; jupiter", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31363)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;11742088;12537568;12537569;12537572;12537573;12537574;16110336;16518797;17372656;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Binds to all microtubule populations., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8IGC9;Q8IGZ9;Q8IH61;Q8INK0;Q8INK1;Q8SXM9;Q8T0S5;Q9I7K1;Q9VGL5;Q9VGL6", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005819 spindle;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005875 microtubule associated complex", "go_biological_process": "GO:0031116 positive regulation of microtubule polymerization", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9I7K0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IN81-1", "uniprot_id": [ { "id": "FRU_DROME", "url": "https://www.uniprot.org/uniprot/Q8IN81", "type": "external" } ], "mass": 102880.0, "length": 955, "protein_name": "Sex determination protein fruitless", "gene_name": "fru", "organism": "Fruit fly", "refseq_name": "fruitless, isoform N", "refseq_ac": [ { "id": "NP_001163648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163648", "type": "external" } ], "gene_names_uniprotkb": "fru; BTB-VI; BtbVI; CG14307; CG7688; CG7689; CG7690; CT22773; Dmel\\CG14307; Dmel_CG14307; Dmfru; FRU-PI; FRU; FruM; Fru; cg7688; cg7689; fruC; fry; fty; ms(3)06411; sat", "gene_names_refseq": "BTB-VI; BtbVI; CG14307; CG7688; CG7689; CG7690; CT22773; Dmel\\CG14307; Dmfru; FRU-PI; FRU; FruM; Fru; cg7688; cg7689; fruC; fru; fry; fty; ms(3)06411; sat", "protein_names_uniprotkb": "Sex determination protein fruitless", "protein_names_refseq": "BTB-protein-VI; CG14307-PN; fru-PN; fru-satori; fruitless, isoform N; fruitless; fruity", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14307)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10731132;10934470;12435630;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;7938017;8790392;8978612;9418892", "class_list": "", "function": "Probably acts as a transcriptional regulator. Part of the somatic sex determination hierarchy; sex determination genes transformer (tra) and transformer-2 (tra-2) switch fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site. Vital for the development of males and females. Controls the development of the male specific abdominal muscle of Lawrence. Plays a role in male courtship behavior and sexual orientation. Enhances male-specific expression of takeout in brain-associated fat body., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V334;O44708;P91618;P91619;Q24004;Q29QE0;Q7KSD2;Q7KSD5;Q7KSD6;Q8IN80;Q8IN82;Q8IN83;Q8IS35;Q8IS36;Q9GU18;Q9GU19;Q9GU20;Q9GU21;Q9GU22;Q9VE64;Q9VE65;Q9VE66;Q9VE67", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007530 sex determination;GO:0008049 male courtship behavior;GO:0046661 male sex differentiation;GO:0060179 male mating behavior;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q8IN81-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q86B91-1", "uniprot_id": [ { "id": "TINC_DROME", "url": "https://www.uniprot.org/uniprot/Q86B91", "type": "external" } ], "mass": 163381.0, "length": 1513, "protein_name": "Protein tincar", "gene_name": "tinc", "organism": "Fruit fly", "refseq_name": "tincar, isoform G", "refseq_ac": [ { "id": "NP_001262686", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262686", "type": "external" } ], "gene_names_uniprotkb": "tinc; CG14319; CG14320; CG31246; CG31247; CG7723; Dmel\\CG31247; Dmel_CG31247", "gene_names_refseq": "CG14319; CG14320; CG31246; CG31247; CG7723; Dmel\\CG31247; tinc", "protein_names_uniprotkb": "Protein tincar", "protein_names_refseq": "CG31247-PG; tinc-PG; tincar, isoform G; tincar", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31247)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;14516698;15654626;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Involved in eye morphogenesis. May be essential for the normal differentiation of ommatidial cells., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4V318;Q1EBX7;Q1EBX9;Q6NP49;Q86B90;Q8MUW7;Q8MZ15;Q9VEE7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0042478 regulation of eye photoreceptor cell development", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q86B91-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7JQF1-1", "uniprot_id": [ { "id": "OAMB_DROME", "url": "https://www.uniprot.org/uniprot/Q7JQF1", "type": "external" } ], "mass": 71702.0, "length": 645, "protein_name": "Octopamine receptor Oamb", "gene_name": "Oamb", "organism": "Fruit fly", "refseq_name": "octopamine receptor in mushroom bodies, isoform B", "refseq_ac": [ { "id": "NP_524669", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524669", "type": "external" } ], "gene_names_uniprotkb": "Oamb; CG15698; CG3856; Dm-OAMB; DmOA1A; DmOA1B; DmOAMB; DmOCT1B; DmOctalpha1Rb; Dmel\\CG3856; Dmel_CG3856; Dmoa1; GPCR; OAMB-1a; OAMB-AS; OAMB-K3; OAMBII; OAMB; OCTR; Oamb a; Oamb b; Oamb1; Oct&agr-1R; OctR1; OctR; oa1; oamb", "gene_names_refseq": "CG15698; CG3856; Dm-OAMB; DmOA1A; DmOA1B; DmOAMB; DmOCT1B; DmOctalpha1Rb; Dmel\\CG3856; Dmoa1; GPCR; OAMB-1a; OAMB-AS; OAMB-K3; OAMBII; OAMB; OCTR; Oamb a; Oamb b; Oamb1; Oamb; Oct&agr-1R; OctR1; OctR; oamb", "protein_names_uniprotkb": "Octopamine receptor Oamb; Octopamine receptor in mushroom bodies", "protein_names_refseq": "CG3856-PB; OAMB; Oamb-PB; octopamine mushroom body receptor; octopamine receptor OAMB; octopamine receptor in mushroom bodies, isoform B; octopamine receptor; octopamine-activated G-protein-coupled receptor", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3856)", "pathway_count": 1, "publication_count": 23, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;14623240;15816867;16110336;17569856;17569867;19262750;20223202;23055498;23103875;23345239;24923784;25589440;25728694;25743690;26109356;26109357;26473732;9570796", "class_list": "", "function": "Receptor for octopamine (OA) which is a neurotransmitter, neurohormone and neuromodulator in invertebrates (PubMed:15816867, PubMed:9570796). Stimulates intracellular accumulation of cAMP and Ca(2+) following ligand binding (PubMed:15816867, PubMed:9570796). Required for ovulation (PubMed:14623240, PubMed:19262750). Following activation on mature follicle cells by OA, induces activity of the metalloprotease Mmp2 which leads to breakdown of the posterior follicle wall, resulting in ovulation (PubMed:26473732). Ligand binding probably also leads to activation of CamKII which is also required for ovulation (PubMed:19262750). Modulates sleep/wake behavior by acting in neurons of the pars intercerebralis to promote wakefulness (PubMed:20223202). Plays a role in courtship conditioning where the courtship behavior of males rejected by already mated females is inhibited with further females (PubMed:23055498). Required in the mushroom body for appetitive olfactory learning (PubMed:23103875, PubMed:23345239). Specifically conveys the short-term reinforcing effects of sweet taste (PubMed:23103875, PubMed:25728694). In insulin-producing cells of the brain, plays a role in inhibiting transcription of insulin-like peptide Ilp3 (PubMed:24923784). Also plays a role in social behavior by modulating male agression (PubMed:24923784)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O61730;Q9VDJ6", "ec_number_list": [], "go_molecular_function": "GO:0030594 neurotransmitter receptor activity;GO:0004989 octopamine receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0008049 male courtship behavior;GO:0060279 positive regulation of ovulation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006979 response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q7JQF1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VI58-1", "uniprot_id": [ { "id": "TUTT_DROME", "url": "https://www.uniprot.org/uniprot/Q9VI58", "type": "external" } ], "mass": 63945.0, "length": 560, "protein_name": "Terminal uridylyltransferase Tailor", "gene_name": "Tailor", "organism": "Fruit fly", "refseq_name": "tailor, isoform B", "refseq_ac": [ { "id": "NP_649693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649693", "type": "external" } ], "gene_names_uniprotkb": "Tailor; CG1091; DmTailor; Dmel\\CG1091; Dmel_CG1091; TAIL; TUTase6; anon-WO0118547.222; tailor", "gene_names_refseq": "CG1091; DmTailor; Dmel\\CG1091; TAIL; TUTase6; Tailor; anon-WO0118547.222; tailor", "protein_names_uniprotkb": "Terminal uridylyltransferase Tailor; 2.7.7.52; TUTase Tailor", "protein_names_refseq": "3' terminal uridylyl transferase 6; CG1091-PB; TUTase; Tailor-PB; tailor, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1091)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;26145174;26145176", "class_list": "", "function": "Uridylyltransferase which mediates terminal uridylation of miRNAs, leading to their degradation. Has high specificity for splicing-derived miRNAs (mirtrons) and other miRNA substrates containing a 3'-G terminal nucleotide. Appears to be a major suppressor of mirtron biogenesis., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0050265 RNA uridylyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0031047 regulatory ncRNA-mediated gene silencing;GO:2000627 positive regulation of miRNA catabolic process;GO:2000632 negative regulation of pre-miRNA processing;GO:0031123 RNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VI58-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VCG3-1", "uniprot_id": [ { "id": "OPA32_DROME", "url": "https://www.uniprot.org/uniprot/Q9VCG3", "type": "external" } ], "mass": 28691.0, "length": 255, "protein_name": "Putative OPA3-like protein CG13603", "gene_name": "Dmel\\CG13601", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": [ { "id": "NP_651192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651192", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG13601; CG13601; Dmel_CG13601", "gene_names_refseq": "CG13601; Dmel\\CG13601", "protein_names_uniprotkb": "Putative OPA3-like protein CG13603", "protein_names_refseq": "CG13601-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "3-methylglutaconic aciduria type 3 (Disease Ontology:DOID:0110004); optic atrophy 3 (Disease Ontology:DOID:0111433)", "pathway": " (dme:Dmel_CG13601)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0019216 regulation of lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VCG3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VG09-1", "uniprot_id": [ { "id": "YELF_DROME", "url": "https://www.uniprot.org/uniprot/Q9VG09", "type": "external" } ], "mass": 49108.0, "length": 429, "protein_name": "L-dopachrome tautomerase yellow-f", "gene_name": "yellow-f", "organism": "Fruit fly", "refseq_name": "yellow-f, isoform A", "refseq_ac": [ { "id": "NP_524335", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524335", "type": "external" } ], "gene_names_uniprotkb": "yellow-f; CG18550; DCDT; DI; Dmel\\CG18550; Dmel_CG18550; Yellow-F; Yellow-f; yell-f; yellow f", "gene_names_refseq": "CG18550; DCDT; DI; Dmel\\CG18550; Yellow-F; Yellow-f; yell-f; yellow f; yellow-f", "protein_names_uniprotkb": "L-dopachrome tautomerase yellow-f; 5.3.3.12", "protein_names_refseq": "CG18550-PA; Yellow-F; dopachrome decarboxylase/tautomerase; dopachrome isomerase; yellow f; yellow-f, isoform A; yellow-f-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18550)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12164780;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Tautomerization of L-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). Also catalyzes the tautomerization of the methyl ester of L-dopachrome and dopamine chrome. May play a role in melanization reactions during late pupal and adult stages. May play a role in melanization reactions during larval and early pupal stages., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q86NV9", "ec_number_list": [ { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" } ], "go_molecular_function": "GO:0004167 dopachrome isomerase activity;GO:0106417 dopaminechrome tautomerase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0048066 developmental pigmentation;GO:0006583 melanin biosynthetic process from tyrosine;GO:0042435 indole-containing compound biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VG09-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VBM6-1", "uniprot_id": [ { "id": "Q9VBM6_DROME", "url": "https://www.uniprot.org/uniprot/Q9VBM6", "type": "external" } ], "mass": 32196.0, "length": 276, "protein_name": "Palmitoyltransferase", "gene_name": "CG17196-PA; Dmel\\CG17196", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": [ { "id": "NP_651426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651426", "type": "external" } ], "gene_names_uniprotkb": "CG17196-PA; Dmel\\CG17196; CG17196-PA; CG17196; Dmel\\CG17196; Dmel_CG17196", "gene_names_refseq": "CG17196-PA; CG17196; Dmel\\CG17196", "protein_names_uniprotkb": "Palmitoyltransferase; 2.3.1.225", "protein_names_refseq": "CG17196-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17196)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006612 protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VBM6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VB11-1", "uniprot_id": [ { "id": "UNC80_DROME", "url": "https://www.uniprot.org/uniprot/Q9VB11", "type": "external" } ], "mass": 367919.0, "length": 3303, "protein_name": "Protein unc-80 homolog", "gene_name": "unc80", "organism": "Fruit fly", "refseq_name": "uncoordinated 80, isoform C", "refseq_ac": [ { "id": "NP_651577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651577", "type": "external" } ], "gene_names_uniprotkb": "unc80; CG18437; Dmel\\CG18437; Dmel_CG18437; Dunc80; UNC80", "gene_names_refseq": "CG18437; Dmel\\CG18437; Dunc80; UNC80; unc80", "protein_names_uniprotkb": "Protein unc-80 homolog", "protein_names_refseq": "CG18437-PC; unc80-PC; uncoordinated 80, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18437); (R-DME-2672351)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17350263;17569856;17569867;24223770;25589440;26109356;26109357", "class_list": "", "function": "Component of the na (narrow abdomen) sodium channel complex. In the circadian clock neurons it functions with na and unc79 to promote circadian rhythmicity., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005261 monoatomic cation channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0030424 axon", "go_biological_process": "GO:0006812 monoatomic cation transport;GO:0045475 locomotor rhythm;GO:0055080 monoatomic cation homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VB11-1", "record_type": "protein", "filter_code": "0000000.0000101.001000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VCR3-1", "uniprot_id": [ { "id": "COW_DROME", "url": "https://www.uniprot.org/uniprot/Q9VCR3", "type": "external" } ], "mass": 71474.0, "length": 629, "protein_name": "Proteoglycan Cow", "gene_name": "Cow", "organism": "Fruit fly", "refseq_name": "carrier of wingless, isoform D", "refseq_ac": [ { "id": "NP_001097883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097883", "type": "external" } ], "gene_names_uniprotkb": "Cow; CG13830; Dmel\\CG13830; Dmel_CG13830; cow", "gene_names_refseq": "CG13830; Cow; Dmel\\CG13830; cow", "protein_names_uniprotkb": "Proteoglycan Cow; Carrier of wg; Carrier of wingless", "protein_names_refseq": "CG13830-PD; Cow-PD; carrier of wingless, isoform D; carrier of wingless", "tax_id": 7227, "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dme:Dmel_CG13830)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25360738;25589440;26109356;26109357", "class_list": "", "function": "Binds to the Wnt signaling protein wg, stabilizes it and promotes its extracellular distribution. This is required for establishment of a wg gradient during development to allow for regulation of target genes at different levels., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B5RJH8", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005509 calcium ion binding;GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0006858 extracellular transport;GO:0007367 segment polarity determination;GO:0048190 wing disc dorsal/ventral pattern formation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VCR3-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VEV4-1", "uniprot_id": [ { "id": "CL16A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VEV4", "type": "external" } ], "mass": 119367.0, "length": 1067, "protein_name": "Protein CLEC16A homolog", "gene_name": "ema", "organism": "Fruit fly", "refseq_name": "endosomal maturation defective, isoform B", "refseq_ac": [ { "id": "NP_001034058", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034058", "type": "external" } ], "gene_names_uniprotkb": "ema; CG12753; Dmel\\CG12753; Dmel_CG12753; Ema", "gene_names_refseq": "CG12753; Dmel\\CG12753; Ema; ema", "protein_names_uniprotkb": "Protein CLEC16A homolog; Endosomal maturation defective protein", "protein_names_refseq": "CG12753-PB; ema-PB; endosomal maturation defective, isoform B", "tax_id": 7227, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); Addison's disease (Disease Ontology:DOID:13774); multiple sclerosis (Disease Ontology:DOID:2377); rheumatoid arthritis (Disease Ontology:DOID:7148); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dme:Dmel_CG12753)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;20194640;22493244;25589440;26109356;26109357", "class_list": "", "function": "Required for mitophagy, autophagy and endosome maturation, possibly by acting in multiple membrane trafficking pathways (PubMed:20194640, PubMed:22493244). Required for endosome trafficking and maturation (PubMed:20194640). Functions with the class C Vps-HOPS complex member Vps16a to promote endosomal maturation into degradative late endosomes and lysosomes (PubMed:20194640). In response to starvation, functions at an early stage of autophagy to promote autophagosome growth and efficient autophagy (PubMed:22493244). Essential for the recruitment of lva-positive Golgi elements to autophagosomes (PubMed:22493244). Likely to function by promoting membrane traffic from the Golgi complex to the developing autophagosomes (PubMed:22493244). Also regulates synaptic growth at the neuromuscular junctions (NMJ) by down-regulating BMP signaling (PubMed:20194640)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BIH5;Q8MRD4", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0007034 vacuolar transport;GO:0006914 autophagy;GO:0008333 endosome to lysosome transport;GO:0016197 endosomal transport;GO:1901096 regulation of autophagosome maturation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VEV4-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VFC8-1", "uniprot_id": [ { "id": "GYS_DROME", "url": "https://www.uniprot.org/uniprot/Q9VFC8", "type": "external" } ], "mass": 81754.0, "length": 709, "protein_name": "Glycogen [starch] synthase", "gene_name": "Glys", "organism": "Fruit fly", "refseq_name": "glycogen synthase, isoform D", "refseq_ac": [ { "id": "NP_001262583", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262583", "type": "external" } ], "gene_names_uniprotkb": "Glys; CG6904; CG6940; Dmel\\CG6904; Dmel_CG6904; GS; GlyS; Gys; anon-WO0118547.108; dGS", "gene_names_refseq": "CG6904; CG6940; Dmel\\CG6904; GS; GlyS; Glys; Gys; anon-WO0118547.108; dGS", "protein_names_uniprotkb": "Glycogen [starch] synthase; 2.4.1.11; Glycogen synthase", "protein_names_refseq": "CG6904-PD; Glys-PD; glycogen synthase, isoform D; glycogen synthase", "tax_id": 7227, "disease": "cardiovascular system disease (Disease Ontology:DOID:1287); glycogen storage disease (Disease Ontology:DOID:2747); Lafora disease (Disease Ontology:DOID:3534)", "pathway": " (dme:Dmel_CG6904); (R-DME-3322077)", "pathway_count": 2, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17372656;17569856;17569867;18327897;24265594;25589440;26109356;26109357", "class_list": "glycogene;glycosyltransferase", "function": "Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan., [UniProtKB, UniProtKB]; Transfers the glycosyl residue from UDPG to the non-reducing end of alpha-1,4-glucan. In larval skeletal muscle, isoform B is required for the formation of autophagosomes during starvation and during cloroquine-induced vacuolar myopathy., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4V2X5", "ec_number_list": [ { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "2.4.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.18", "type": "external" }, { "id": "2.4.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.11", "type": "external" } ], "go_molecular_function": "GO:0004373 alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle;GO:0005776 autophagosome", "go_biological_process": "GO:0005978 glycogen biosynthetic process;GO:0009267 cellular response to starvation;GO:0009744 response to sucrose;GO:0071329 cellular response to sucrose stimulus;GO:0160249 glycogen biosynthetic process via UDP-glucose", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VFC8-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000001001.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MT36-1", "uniprot_id": [ { "id": "NSD_DROME", "url": "https://www.uniprot.org/uniprot/Q8MT36", "type": "external" } ], "mass": 159028.0, "length": 1427, "protein_name": "Nuclear receptor binding SET domain protein", "gene_name": "NSD", "organism": "Fruit fly", "refseq_name": "nuclear receptor binding SET domain protein, isoform A", "refseq_ac": [ { "id": "NP_733239", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_733239", "type": "external" } ], "gene_names_uniprotkb": "NSD; CG4976; Dmel\\CG4976; Dmel_CG4976; MES-4; Mes-4; dMES-4; dMes-4", "gene_names_refseq": "CG4976; Dmel\\CG4976; MES-4; Mes-4; NSD; dMES-4; dMes-4", "protein_names_uniprotkb": "Nuclear receptor binding SET domain protein; 2.1.1.357; Maternal-effect sterile 4 homolog; Probable histone-lysine N-methyltransferase Mes-4", "protein_names_refseq": "CG4976-PA; Mes-4; NSD-PA; nuclear receptor binding SET domain protein, isoform A", "tax_id": 7227, "disease": "Wolf-Hirschhorn syndrome (Disease Ontology:DOID:0050460); Sotos syndrome 1 (Disease Ontology:DOID:0112103); microcephaly (Disease Ontology:DOID:10907); Sotos syndrome (Disease Ontology:DOID:14748); syndrome (Disease Ontology:DOID:225); lung non-small cell carcinoma (Disease Ontology:DOID:3908); neuroblastoma (Disease Ontology:DOID:769); myeloid leukemia (Disease Ontology:DOID:8692); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (dme:Dmel_CG4976)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Probable histone methyltransferase. Histone methylation gives specific tags for epigenetic transcriptional activation or repression (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q1LZ05;Q9VAY5", "ec_number_list": [ { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0031490 chromatin DNA binding;GO:0042054 histone methyltransferase activity;GO:0046975 histone H3K36 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0000228 nuclear chromosome;GO:0000792 heterochromatin;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8MT36-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3LHL9-1", "uniprot_id": [ { "id": "WGE_DROME", "url": "https://www.uniprot.org/uniprot/Q3LHL9", "type": "external" } ], "mass": 178316.0, "length": 1658, "protein_name": "Protein winged eye", "gene_name": "wge", "organism": "Fruit fly", "refseq_name": "winged eye, isoform C", "refseq_ac": [ { "id": "NP_001036746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036746", "type": "external" } ], "gene_names_uniprotkb": "wge; CG17621; CG31151; CG4902; Dmel\\CG31151; Dmel_CG31151; Wge", "gene_names_refseq": "CG17621; CG31151; CG4902; Dmel\\CG31151; Wge; wge", "protein_names_uniprotkb": "Protein winged eye", "protein_names_refseq": "CG31151-PC; wge-PC; winged eye, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31151)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;16247005;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Functions in the determination of disk-specific identity, downstream of Hox genes. Overexpression induces ectopic wings with antero-posterior and dorso-ventral axes in the eye field. Overexpression is sufficient for ectopic expression of vg in eye disks., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "C6TPA0;Q7KS56;Q8MSX3;Q9VCV6", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0000785 chromatin;GO:0035363 histone locus body", "go_biological_process": "GO:0030154 cell differentiation;GO:0010468 regulation of gene expression;GO:0031453 positive regulation of heterochromatin formation;GO:0007560 imaginal disc morphogenesis;GO:0141005 transposable element silencing by heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q3LHL9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VCI3-1", "uniprot_id": [ { "id": "LSD1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VCI3", "type": "external" } ], "mass": 48833.0, "length": 431, "protein_name": "Lipid storage droplets surface-binding protein 1", "gene_name": "Lsd-1", "organism": "Fruit fly", "refseq_name": "lipid storage droplet-1, isoform D", "refseq_ac": [ { "id": "NP_001262883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262883", "type": "external" } ], "gene_names_uniprotkb": "Lsd-1; CG10374; DmPLIN1; Dmel\\CG10374; Dmel_CG10374; LSD-1; LSD1; LSDP1; Lsd1; Lsdp1; PLIN1; Plin1; dLSD1; dPlin1; dmPLIN1; lsd-1; lsd1; plin1", "gene_names_refseq": "CG10374; DmPLIN1; Dmel\\CG10374; LSD-1; LSD1; LSDP1; Lsd-1; Lsd1; Lsdp1; PLIN1; Plin1; dLSD1; dPlin1; dmPLIN1; lsd-1; lsd1; plin1", "protein_names_uniprotkb": "Lipid storage droplets surface-binding protein 1", "protein_names_refseq": "CG10374-PD; Lsd-1-PD; lipid storage droplet protein 1; lipid storage droplet-1, isoform D; lipid storage droplets surface binding protein; perilipin 1; perilipin", "tax_id": 7227, "disease": "obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG10374)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12077142;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Required for normal deposition of neutral lipids in the oocyte., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7KS41;Q9BIJ6;Q9VCI1;Q9VCI2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0032994 protein-lipid complex", "go_biological_process": "GO:0006869 lipid transport;GO:0010898 positive regulation of triglyceride catabolic process;GO:0010890 positive regulation of triglyceride storage;GO:0019915 lipid storage;GO:0010883 regulation of lipid storage", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VCI3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VCA2-1", "uniprot_id": [ { "id": "ORCT_DROME", "url": "https://www.uniprot.org/uniprot/Q9VCA2", "type": "external" } ], "mass": 61003.0, "length": 548, "protein_name": "Organic cation transporter protein", "gene_name": "Orct", "organism": "Fruit fly", "refseq_name": "organic cation transporter, isoform B", "refseq_ac": [ { "id": "NP_001262908", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262908", "type": "external" } ], "gene_names_uniprotkb": "Orct; 13; CG6331; Dmel\\CG6331; Dmel_CG6331; SLC22A5; orct", "gene_names_refseq": "CG6331; Dmel\\CG6331; Orct; SLC22A5/13; SLC22A5; orct", "protein_names_uniprotkb": "Organic cation transporter protein", "protein_names_refseq": "CG6331-PB; Orct-PB; organic cation transporter, isoform B", "tax_id": 7227, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); myelodysplastic syndrome (Disease Ontology:DOID:0050908); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); kidney failure (Disease Ontology:DOID:1074); extrahepatic cholestasis (Disease Ontology:DOID:13619); systemic primary carnitine deficiency disease (Disease Ontology:DOID:14365); intrahepatic cholestasis (Disease Ontology:DOID:1852); hyperuricemia (Disease Ontology:DOID:1920); asthma (Disease Ontology:DOID:2841); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); congestive heart failure (Disease Ontology:DOID:6000); inherited metabolic disorder (Disease Ontology:DOID:655); rheumatoid arthritis (Disease Ontology:DOID:7148); end stage renal disease (Disease Ontology:DOID:783); Crohn's disease (Disease Ontology:DOID:8778)", "pathway": " (dme:Dmel_CG6331); (R-DME-112311); (R-DME-181430); (R-DME-196807); (R-DME-200425); (R-DME-2161517); (R-DME-442660); (R-DME-549127); (R-DME-561048); (R-DME-917937); (R-DME-9749641); (R-DME-9793528)", "pathway_count": 12, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;19349973;25589440;26109356;26109357;9409773", "class_list": "", "function": "Probably transports organic cations., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 16, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O01383;O01384", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VCA2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V4K2-1", "uniprot_id": [ { "id": "GR43A_DROME", "url": "https://www.uniprot.org/uniprot/Q9V4K2", "type": "external" } ], "mass": 47573.0, "length": 427, "protein_name": "Gustatory receptor for sugar taste 43a", "gene_name": "Gr43a", "organism": "Fruit fly", "refseq_name": "gustatory receptor 43a, isoform A", "refseq_ac": [ { "id": "NP_523650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523650", "type": "external" } ], "gene_names_uniprotkb": "Gr43a; 43C.1; 43C1; CG1712; DmGr43a; Dmel\\CG1712; Dmel_CG1712; GR43.1; GR43C.1; GR43a; Gr43C1; gr43a", "gene_names_refseq": "43C.1; 43C1; CG1712; DmGr43a; Dmel\\CG1712; GR43C.1; GR43a; Gr43C1; Gr43a; gr43a", "protein_names_uniprotkb": "Gustatory receptor for sugar taste 43a", "protein_names_refseq": "CG1712-PA; Gr43a-PA; gustatory receptor 43C.1; gustatory receptor 43a, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1712)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10710312;10731132;11516643;12537568;12537572;12537573;12537574;16110336;17569856;17569867;21709218;22031876;23178127;23850280;25589440;26109356;26109357;38305684", "class_list": "", "function": "Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates., [UniProtKB, UniProtKB, UniProtKB]; Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr43a is the main sugar receptor in larvae. Functions as a narrowly tuned fructose receptor in taste neurons but also as a fructose receptor in the brain. Necessary and sufficient to sense hemolymph fructose and promote feeding in hungry flies but suppress feeding in satiated flies., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 21, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V4B7", "ec_number_list": [], "go_molecular_function": "GO:0033041 sweet taste receptor activity;GO:0008527 taste receptor activity;GO:0099094 ligand-gated monoatomic cation channel activity;GO:0170023 ionotropic sweet taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0008049 male courtship behavior;GO:0007165 signal transduction;GO:0032098 regulation of appetite;GO:0098655 monoatomic cation transmembrane transport;GO:0008343 adult feeding behavior", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9V4K2-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7JWR9-1", "uniprot_id": [ { "id": "ZC3HF_DROME", "url": "https://www.uniprot.org/uniprot/Q7JWR9", "type": "external" } ], "mass": 45292.0, "length": 404, "protein_name": "Zinc finger CCCH domain-containing protein 15 homolog", "gene_name": "Dmel\\CG8635", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001286202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286202", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG8635; CG8635; Dmel_CG8635", "gene_names_refseq": "CG8635; Dmel\\CG8635", "protein_names_uniprotkb": "Zinc finger CCCH domain-containing protein 15 homolog; DRG family regulatory protein 1 homolog", "protein_names_refseq": "CG8635-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8635); (R-DME-9629569)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15676025;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q7JWR9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V5E1-1", "uniprot_id": [ { "id": "PAL1_DROME", "url": "https://www.uniprot.org/uniprot/Q9V5E1", "type": "external" } ], "mass": 59642.0, "length": 541, "protein_name": "Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 1", "gene_name": "Pal1", "organism": "Fruit fly", "refseq_name": "Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 1, isoform D", "refseq_ac": [ { "id": "NP_001137630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137630", "type": "external" } ], "gene_names_uniprotkb": "Pal1; CG12130; DPAL1; Dmel\\CG12130; Dmel_CG12130; PAL1; anon-WO0149856.3; dPAL1; ta", "gene_names_refseq": "CG12130; DPAL1; Dmel\\CG12130; PAL1; Pal1; anon-WO0149856.3; dPAL1; ta", "protein_names_uniprotkb": "Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 1; 4.3.2.5; Peptidylamidoglycolate lyase 1; dPAL1", "protein_names_refseq": "CG12130-PD; Pal1-PD; Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 1, isoform D; tapered", "tax_id": 7227, "disease": "hypothyroidism (Disease Ontology:DOID:1459); prostate adenocarcinoma (Disease Ontology:DOID:2526)", "pathway": " (dme:Dmel_CG12130)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15198673;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Peptidyl-alpha-hydroxylglycine alpha-amidating lyase that catalyzes an essential reaction in C-terminal alpha-amidation of peptides. Mediates the dismutation of the unstable peptidyl(2-hydroxyglycine) intermediate to glyoxylate and the corresponding desglycine peptide amide. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q960U4", "ec_number_list": [ { "id": "4.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.5", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004598 peptidylamidoglycolate lyase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0016020 membrane", "go_biological_process": "GO:0006518 peptide metabolic process;GO:0007619 courtship behavior;GO:0044719 regulation of imaginal disc-derived wing size", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9V5E1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6WV20-1", "uniprot_id": [ { "id": "GALT1_DROME", "url": "https://www.uniprot.org/uniprot/Q6WV20", "type": "external" } ], "mass": 68961.0, "length": 601, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 1", "gene_name": "Pgant1", "organism": "Fruit fly", "refseq_name": "polypeptide N-Acetylgalactosaminyltransferase 1, isoform A", "refseq_ac": [ { "id": "NP_611043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611043", "type": "external" } ], "gene_names_uniprotkb": "Pgant1; CG8182; Dmel\\CG8182; Dmel_CG8182; GalNAc-T1; pgant1", "gene_names_refseq": "CG8182; Dmel\\CG8182; GalNAc-T1; Pgant1; pgant1", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 1; 2.4.1.41; Protein-UDP acetylgalactosaminyltransferase 1; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1; pp-GaNTase 1", "protein_names_refseq": "CG8182-PA; GalNAc-T1; N-acetylgalactosaminyltransferase; Pgant1-PA; polypeptide GalNAc transferase 1; polypeptide N-Acetylgalactosaminyltransferase 1, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8182); (R-DME-190372); (R-DME-913709)", "pathway_count": 3, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;12829714;16110336;16251381;17569856;17569867;25589440;26109356;26109357", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:12829714). It can both act as a peptide transferase that transfers GalNAc onto unmodified peptide substrates, and as a glycopeptide transferase that requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Prefers the monoglycosylated Muc5AC-3 as substrate (PubMed:12829714)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0E964;Q9V7C8", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity;GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005795 Golgi stack", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q6WV20-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q86BE9-1", "uniprot_id": [ { "id": "PEN2_DROME", "url": "https://www.uniprot.org/uniprot/Q86BE9", "type": "external" } ], "mass": 11725.0, "length": 101, "protein_name": "Gamma-secretase subunit pen-2", "gene_name": "pen-2", "organism": "Fruit fly", "refseq_name": "presenilin enhancer, isoform B", "refseq_ac": [ { "id": "NP_001286566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286566", "type": "external" } ], "gene_names_uniprotkb": "pen-2; CG33198; Dmel\\CG33198; Dmel_CG33198; PEN2; Pen-2; anon-AE003800.1; dPEN2; dPen-2", "gene_names_refseq": "CG33198; Dmel\\CG33198; PEN2; Pen-2; anon-AE003800.1; dPEN2; dPen-2; pen-2", "protein_names_uniprotkb": "Gamma-secretase subunit pen-2; Presenilin enhancer protein 2", "protein_names_refseq": "CG33198-PB; pen-2-PB; presenilin enhancer 2; presenilin enhancer, isoform B", "tax_id": 7227, "disease": "hidradenitis suppurativa (Disease Ontology:DOID:2280)", "pathway": " (dme:Dmel_CG33198); (R-DME-1251985); (R-DME-3928665)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10731132;12110170;12537568;12537572;12537573;12537574;12660785;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8E6Z8;Q8MUT4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0055037 recycling endosome;GO:0005770 late endosome;GO:0070765 gamma-secretase complex", "go_biological_process": "GO:0035333 Notch receptor processing, ligand-dependent;GO:0006509 membrane protein ectodomain proteolysis;GO:0007219 Notch signaling pathway;GO:0007220 Notch receptor processing;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q86BE9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V6M7-1", "uniprot_id": [ { "id": "UFSP1_DROME", "url": "https://www.uniprot.org/uniprot/Q4V6M7", "type": "external" } ], "mass": 25791.0, "length": 234, "protein_name": "Probable Ufm1-specific protease 1", "gene_name": "Ufsp1", "organism": "Fruit fly", "refseq_name": "UFM1 specific peptidase 1, isoform B", "refseq_ac": [ { "id": "NP_001286151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286151", "type": "external" } ], "gene_names_uniprotkb": "Ufsp1; CG30157; Dmel\\CG30157; Dmel_CG30157; UfSP1", "gene_names_refseq": "CG30157; Dmel\\CG30157; UfSP1; Ufsp1", "protein_names_uniprotkb": "Probable Ufm1-specific protease 1; 3.4.22.-; UfSP1", "protein_names_refseq": "CG30157-PB; UFM1 specific peptidase 1, isoform B; Ufsp1-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG30157)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0071567 deUFMylase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q4V6M7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V8R9-1", "uniprot_id": [ { "id": "EPB41_DROME", "url": "https://www.uniprot.org/uniprot/Q9V8R9", "type": "external" } ], "mass": 184168.0, "length": 1698, "protein_name": "Protein 4.1 homolog", "gene_name": "cora", "organism": "Fruit fly", "refseq_name": "coracle, isoform A", "refseq_ac": [ { "id": "NP_523791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523791", "type": "external" } ], "gene_names_uniprotkb": "cora; CG11949; COR; Coracle; Cora; Cor; D4.1; Dmel\\CG11949; Dmel_CG11949; cor; l(2)k08713; mdcds_14526", "gene_names_refseq": "CG11949; COR; Coracle; Cora; Cor; D4.1; Dmel\\CG11949; cora; cor; l(2)k08713; mdcds_14526", "protein_names_uniprotkb": "Protein 4.1 homolog; Protein coracle", "protein_names_refseq": "CG11949-PA; D4.1-Coracle; cora-PA; coracle, isoform A; coracle", "tax_id": 7227, "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); autosomal dominant intellectual developmental disorder 11 (Disease Ontology:DOID:0070041); hereditary elliptocytosis (Disease Ontology:DOID:2373); meningioma (Disease Ontology:DOID:3565); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748)", "pathway": " (dme:Dmel_CG11949); (R-DME-6794361)", "pathway_count": 2, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17372656;17569856;17569867;18327897;25589440;26109356;26109357;40245499;8162854", "class_list": "", "function": "An integral component of the septate junction. May play a role in cell-cell interactions that are necessary for proper development. Vital for embryonic development., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "A1ZBI0;Q1WWD0;Q24440;Q24441;Q24442;Q9V8R8;Q9V8S0", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005918 septate junction;GO:0005920 smooth septate junction;GO:0071944 cell periphery", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0006612 protein targeting to membrane;GO:0031032 actomyosin structure organization;GO:0060857 establishment of glial blood-brain barrier;GO:0045216 cell-cell junction organization", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9V8R9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q961C9-1", "uniprot_id": [ { "id": "TNG11_DROME", "url": "https://www.uniprot.org/uniprot/Q961C9", "type": "external" } ], "mass": 31541.0, "length": 277, "protein_name": "Transport and Golgi organization protein 11", "gene_name": "Tango11", "organism": "Fruit fly", "refseq_name": "transport and golgi organization 11, isoform A", "refseq_ac": [ { "id": "NP_726111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_726111", "type": "external" } ], "gene_names_uniprotkb": "Tango11; BEST:LD33633; BcDNA:LD22567; CG30404; Dmel\\CG30404; Dmel_CG30404; TANGO11; anon-EST:fe1F11; tango11", "gene_names_refseq": "BEST:LD33633; BcDNA:LD22567; CG30404; Dmel\\CG30404; TANGO11; Tango11; anon-EST:fe1F11; tango11", "protein_names_uniprotkb": "Transport and Golgi organization protein 11; Tango-11", "protein_names_refseq": "CG30404-PA; Tango11-PA; anon-fast-evolving-1F11; tango11; transport and golgi organization 11, isoform A; transport and golgi organization", "tax_id": 7227, "disease": "encephalopathy due to defective mitochondrial and peroxisomal fission 2 (Disease Ontology:DOID:0060994); transient cerebral ischemia (Disease Ontology:DOID:224)", "pathway": " (dme:Dmel_CG30404)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;16452979;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "May play a role in mitochondrial and peroxisomal fission., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016559 peroxisome fission;GO:0009306 protein secretion;GO:0000266 mitochondrial fission", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q961C9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MSU3-1", "uniprot_id": [ { "id": "FRRS1_DROME", "url": "https://www.uniprot.org/uniprot/Q8MSU3", "type": "external" } ], "mass": 70285.0, "length": 647, "protein_name": "Ferric reductase 1", "gene_name": "sdr2", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": [ { "id": "NP_611079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611079", "type": "external" } ], "gene_names_uniprotkb": "sdr2; CG8399; Dmel\\CG8399; Dmel_CG8399; SDR2; anon-EST:ParkEST009", "gene_names_refseq": "CG8399; Dmel\\CG8399; SDR2; anon-EST:ParkEST009; sdr2", "protein_names_uniprotkb": "Ferric reductase 1; 1.-.-.-; stromal cell-derived receptor 2", "protein_names_refseq": "CG8399-PA; stromal cell-derived receptor 2; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8399)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;14499595;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Ferric reductase that reduces Fe(3+) to Fe(2+) and could play a role in iron import into cells (PubMed:14499595). The electron donor and therefore the reaction mechanism are not known (PubMed:14499595)., [UniProtKB, PubMed]; Ferric reductase that reduces Fe(3+) to Fe(2+) and could play a role in iron import into cells. The electron donor and therefore the reaction mechanism are not known., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9V7I1", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016722 oxidoreductase activity, acting on metal ions;GO:0140571 transmembrane ascorbate ferrireductase activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8MSU3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VGA2-1", "uniprot_id": [ { "id": "TI17C_DROME", "url": "https://www.uniprot.org/uniprot/Q9VGA2", "type": "external" } ], "mass": 24159.0, "length": 222, "protein_name": "Probable mitochondrial import inner membrane translocase subunit Tim17 3", "gene_name": "Tim17a1", "organism": "Fruit fly", "refseq_name": "Tim17a1, isoform B", "refseq_ac": [ { "id": "NP_001287301", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287301", "type": "external" } ], "gene_names_uniprotkb": "Tim17a1; CG10090; Dmel\\CG10090; Dmel_CG10090; Tim17 a1", "gene_names_refseq": "CG10090; Dmel\\CG10090; Tim17 a1; Tim17a1", "protein_names_uniprotkb": "Probable mitochondrial import inner membrane translocase subunit Tim17 3", "protein_names_refseq": "CG10090-PB; Tim17a1, isoform B; Tim17a1-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10090); (R-DME-1268020)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5RJ92;Q8MZE4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005744 TIM23 mitochondrial import inner membrane translocase complex;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0030150 protein import into mitochondrial matrix;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VGA2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VED0-1", "uniprot_id": [ { "id": "TAPT1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VED0", "type": "external" } ], "mass": 75566.0, "length": 676, "protein_name": "Protein TAPT1 homolog", "gene_name": "Dmel\\CG7218", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001287385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287385", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG7218; CG7218; Dmel_CG7218", "gene_names_refseq": "CG7218; Dmel\\CG7218", "protein_names_uniprotkb": "Protein TAPT1 homolog", "protein_names_refseq": "CG7218-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7218)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0036064 ciliary basal body;GO:0016020 membrane", "go_biological_process": "GO:0045724 positive regulation of cilium assembly", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VED0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q94547-1", "uniprot_id": [ { "id": "RGA_DROME", "url": "https://www.uniprot.org/uniprot/Q94547", "type": "external" } ], "mass": 59973.0, "length": 585, "protein_name": "Regulator of gene activity", "gene_name": "Rga", "organism": "Fruit fly", "refseq_name": "regena, isoform C", "refseq_ac": [ { "id": "NP_001287183", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287183", "type": "external" } ], "gene_names_uniprotkb": "Rga; CG2138; CG2161; Dmel\\CG2161; Dmel_CG2161; NOT2; Not2; RGA; l(3)03834; not2; rga", "gene_names_refseq": "CG2138; CG2161; Dmel\\CG2161; NOT2; Not2; RGA; Rga; l(3)03834; not2; rga", "protein_names_uniprotkb": "Regulator of gene activity; CCR4-NOT transcription complex subunit 2 homolog; CNOT2; Not2; Protein regena", "protein_names_refseq": "CG2161-PC; Rga-PC; ragena; regena, isoform C; regena", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2161)", "pathway_count": 1, "publication_count": 18, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;20504953;23303381;25589440;26109356;26109357;29887366;33925313;40245499;9475742", "class_list": "", "function": "Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:20504953, PubMed:23303381). Additional complex functions may be a consequence of its influence on mRNA expression (PubMed:23303381). Essential for viability (PubMed:9475742). Acts as a suppressor of position effect variegation (PEV) at the white locus and regulates the expression of several unrelated genes (PubMed:9475742). Plays a role in germline stem cell differentiation in the ovaries (PubMed:29887366)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q1LZ18;Q8IPQ1;Q8T3L5;Q9VNE5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000932 P-body;GO:0030014 CCR4-NOT complex;GO:0030015 CCR4-NOT core complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0017148 negative regulation of translation;GO:0006402 mRNA catabolic process;GO:0031047 regulatory ncRNA-mediated gene silencing", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q94547-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VAS7-1", "uniprot_id": [ { "id": "INX3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VAS7", "type": "external" } ], "mass": 45357.0, "length": 395, "protein_name": "Innexin inx3", "gene_name": "Inx3", "organism": "Fruit fly", "refseq_name": "innexin 3, isoform B", "refseq_ac": [ { "id": "NP_001263050", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263050", "type": "external" } ], "gene_names_uniprotkb": "Inx3; CG1448; Dm-Inx3; Dm-inx3; Dmel\\CG1448; Dmel_CG1448; FBpp0084719; INX-3; Ix3; anon-EST:fe2B11; inx-3; inx3; inx", "gene_names_refseq": "CG1448; Dm-Inx3; Dm-inx3; Dmel\\CG1448; FBpp0084719; INX-3; Inx3; Ix3; anon-EST:fe2B11; inx-3; inx3", "protein_names_uniprotkb": "Innexin inx3; Innexin-3", "protein_names_refseq": "CG1448-PB; Innexin-3; Inx3-PB; anon-fast-evolving-2B11; innexin 3, isoform B; innexin 3; innexin3", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1448)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10731132;10888681;11960713;12537568;12537569;12537572;12537573;12537574;16110336;16436513;17569856;17569867;18327897;19038051;25589440;26109356;26109357", "class_list": "", "function": "Structural component of the gap junctions., [UniProtKB, UniProtKB]; Structural components of the gap junctions. Essential for proper epithelial development of the epidermis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016328 lateral plasma membrane;GO:0005921 gap junction", "go_biological_process": "GO:0034220 monoatomic ion transmembrane transport;GO:0007603 phototransduction, visible light;GO:0007602 phototransduction;GO:0010496 intercellular transport;GO:0007391 dorsal closure", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q9VAS7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VNJ0-1", "uniprot_id": [ { "id": "Q9VNJ0_DROME", "url": "https://www.uniprot.org/uniprot/Q9VNJ0", "type": "external" } ], "mass": 35173.0, "length": 319, "protein_name": "Degringolade, isoform A", "gene_name": "dgrn", "organism": "Fruit fly", "refseq_name": "degringolade, isoform A", "refseq_ac": [ { "id": "NP_649596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649596", "type": "external" } ], "gene_names_uniprotkb": "dgrn; CG10981; Dgrn; Dmel\\CG10981; Dmel_CG10981; STUbL", "gene_names_refseq": "CG10981; Dgrn; Dmel\\CG10981; STUbL; dgrn", "protein_names_uniprotkb": "Degringolade, isoform A", "protein_names_refseq": "CG10981-PA; degringolade, isoform A; degringolade; dgrn-PA", "tax_id": 7227, "disease": "Angelman syndrome (Disease Ontology:DOID:1932)", "pathway": " (dme:Dmel_CG10981); (R-DME-983168)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0032183 SUMO binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0034399 nuclear periphery;GO:0033768 SUMO-targeted ubiquitin ligase complex", "go_biological_process": "GO:0007530 sex determination;GO:0045893 positive regulation of DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0022008 neurogenesis;GO:0045995 regulation of embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VNJ0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KVH9-1", "uniprot_id": [ { "id": "TFP8L_DROME", "url": "https://www.uniprot.org/uniprot/Q7KVH9", "type": "external" } ], "mass": 21387.0, "length": 188, "protein_name": "Protein salivary glands marred", "gene_name": "sigmar", "organism": "Fruit fly", "refseq_name": "salivary glands marred, isoform B", "refseq_ac": [ { "id": "NP_611820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611820", "type": "external" } ], "gene_names_uniprotkb": "sigmar; CG4091; Dmel\\CG4091; Dmel_CG4091", "gene_names_refseq": "CG4091; Dmel\\CG4091; sigmar", "protein_names_uniprotkb": "Protein salivary glands marred; TNF alpha-induced protein 8-like protein; Tumor necrosis factor alpha-induced protein 8-like protein", "protein_names_refseq": "CG4091-PB; salivary glands marred, isoform B; sigmar-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4091); (R-DME-1483255)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;25836674;26109356;26109357", "class_list": "", "function": "Important for modulating JNK signaling, cytoskeletal remodeling and autophagy in larval salivary glands (PubMed:25836674). During salivary gland development, involved in the positive regulation of the JNK signaling pathway, acting downstream of the TNF ligand egr and upstream of bsk (PubMed:25836674)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W1L0", "ec_number_list": [], "go_molecular_function": "GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0042995 cell projection", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0043065 positive regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:1902531 regulation of intracellular signal transduction;GO:0007435 salivary gland morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q7KVH9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VNS0-1", "uniprot_id": [ { "id": "MAEL_DROME", "url": "https://www.uniprot.org/uniprot/Q9VNS0", "type": "external" } ], "mass": 51601.0, "length": 459, "protein_name": "Protein maelstrom", "gene_name": "mael", "organism": "Fruit fly", "refseq_name": "maelstrom, isoform D", "refseq_ac": [ { "id": "NP_001303390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303390", "type": "external" } ], "gene_names_uniprotkb": "mael; CG11254; Dmel\\CG11254; Dmel_CG11254; MAEL; Mael; mae1", "gene_names_refseq": "CG11254; Dmel\\CG11254; MAEL; Mael; mae1; mael", "protein_names_uniprotkb": "Protein maelstrom", "protein_names_refseq": "CG11254-PD; mael-PD; maelstrom, isoform D; maelstrom", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11254)", "pathway_count": 1, "publication_count": 19, "publication_id_list": "10731132;11277405;12537568;12537569;12537572;12537573;12537574;12538514;16110336;17428915;17569856;17569867;19758565;23159368;23913921;25589440;26109356;26109357;9409682", "class_list": "", "function": "Involved both in the piRNA and miRNA metabolic processes. As a component of the meiotic nuage, plays a central role during oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Repression of transposable elements is mediated via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the repression of transposons. As a nuclear component, it is required for proper differentiation in the germline stem cell (GSC) lineage by repressing microRNA-7 (miR-7), thereby acting as an indirect regulator of bag-of-marbles (Bam). Acts by binding to the promoter of miR-7 gene and repressing its expression; miR-7 repression alleviates the Bam repression by miR-7, thereby allowing differentiation in the germline stem cell (GSC) lineage. Indirectly required to position the microtubule organizing center in stage 2-6 oocytes. Involved in repression of long interspersed nuclear elements (LINEs) including HeT-A, I-element, TART and possibly mst40 LINEs; may have a role in production of piwi-interacting RNA (piRNA) (PubMed:17428915)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O17317;Q86BG5", "ec_number_list": [], "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding;GO:0043565 sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0043186 P granule", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0060964 regulation of miRNA-mediated gene silencing;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q9VNS0-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VN27-1", "uniprot_id": [ { "id": "LIPT2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VN27", "type": "external" } ], "mass": 26034.0, "length": 234, "protein_name": "Putative lipoyltransferase 2, mitochondrial", "gene_name": "Lipt2", "organism": "Fruit fly", "refseq_name": "Lipoyl(octanoyl) transferase 2, isoform B", "refseq_ac": [ { "id": "NP_001303459", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303459", "type": "external" } ], "gene_names_uniprotkb": "Lipt2; CG9804; Dmel\\CG9804; Dmel_CG9804", "gene_names_refseq": "CG9804; Dmel\\CG9804; Lipt2", "protein_names_uniprotkb": "Putative lipoyltransferase 2, mitochondrial; 2.3.1.181; Lipoate-protein ligase B; Lipoyl/octanoyl transferase; Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase", "protein_names_refseq": "CG9804-PB; Lipoyl(octanoyl) transferase 2, isoform B; Lipt2-PB", "tax_id": 7227, "disease": "dystonia (Disease Ontology:DOID:543); glycine encephalopathy (Disease Ontology:DOID:9268)", "pathway": " (dme:Dmel_CG9804); (R-DME-9857492)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.181", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.181", "type": "external" } ], "go_molecular_function": "GO:0033819 lipoyl(octanoyl) transferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0009249 protein lipoylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VN27-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VEJ2-1", "uniprot_id": [ { "id": "NOP14_DROME", "url": "https://www.uniprot.org/uniprot/Q9VEJ2", "type": "external" } ], "mass": 97552.0, "length": 852, "protein_name": "Nucleolar protein 14 homolog", "gene_name": "l(3)07882", "organism": "Fruit fly", "refseq_name": "lethal (3) 07882, isoform B", "refseq_ac": [ { "id": "NP_001303435", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303435", "type": "external" } ], "gene_names_uniprotkb": "l(3)07882; CG5824; Dmel\\CG5824; Dmel_CG5824", "gene_names_refseq": "CG5824; Dmel\\CG5824; l(3)07882", "protein_names_uniprotkb": "Nucleolar protein 14 homolog; Nucleolar complex protein 14 homolog", "protein_names_refseq": "CG5824-PB; l(3)07882-PB; lethal (3) 07882, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5824); (R-DME-6791226)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030515 snoRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0030692 Noc4p-Nop14p complex;GO:0032040 small-subunit processome", "go_biological_process": "GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis;GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VEJ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6NN40-1", "uniprot_id": [ { "id": "NTM1_DROME", "url": "https://www.uniprot.org/uniprot/Q6NN40", "type": "external" } ], "mass": 30602.0, "length": 276, "protein_name": "Alpha N-terminal protein methyltransferase 1", "gene_name": "Ntmt", "organism": "Fruit fly", "refseq_name": "N-terminal methyltransferase, isoform A", "refseq_ac": [ { "id": "NP_610528", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610528", "type": "external" } ], "gene_names_uniprotkb": "Ntmt; CG1675; Dmel\\CG1675; Dmel_CG1675; dNTMT", "gene_names_refseq": "CG1675; Dmel\\CG1675; Ntmt; dNTMT", "protein_names_uniprotkb": "Alpha N-terminal protein methyltransferase 1; 2.1.1.244; NTM1; X-Pro-Lys N-terminal protein methyltransferase 1", "protein_names_refseq": "CG1675-PA; N-terminal methyltransferase, isoform A; Ntmt-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1675)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.244", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.244", "type": "external" } ], "go_molecular_function": "GO:0071885 N-terminal protein N-methyltransferase activity;GO:0042054 histone methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q6NN40-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9U1H9-1", "uniprot_id": [ { "id": "NXF1_DROME", "url": "https://www.uniprot.org/uniprot/Q9U1H9", "type": "external" } ], "mass": 76249.0, "length": 672, "protein_name": "Nuclear RNA export factor 1", "gene_name": "sbr", "organism": "Fruit fly", "refseq_name": "small bristles, isoform A", "refseq_ac": [ { "id": "NP_524660", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524660", "type": "external" } ], "gene_names_uniprotkb": "sbr; CG1664; CG17335; CT4634; DNXF-1; Dm nxf1; DmNXF1; Dmel\\CG1664; Dmel_CG1664; NFX1; NXF1-p15; NXF1; Nxf1; PABPr; SBR; Sbr; dNXF1; dNxf1; dTap; l(1)9Fd; l(1)G1; l(1)ts403; l(1)ts; nfx1; nxf1; sbt", "gene_names_refseq": "CG1664; CG17335; CT4634; DNXF-1; Dm nxf1; DmNXF1; Dmel\\CG1664; NFX1; NXF1-p15; NXF1; Nxf1; PABPr; SBR; Sbr; dNXF1; dNxf1; dTap; l(1)9Fd; l(1)G1; l(1)ts403; l(1)ts; nfx1; nxf1; sbr; sbt", "protein_names_uniprotkb": "Nuclear RNA export factor 1; Protein small bristles; Protein tip-associating", "protein_names_refseq": "CG1664-PA; Nxf1; locus 1; nuclear export factor 1; sbr-PA; shorter-bristles; small bristles, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1664); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236)", "pathway_count": 5, "publication_count": 22, "publication_id_list": "10731132;11779805;11780633;11780634;12537568;12537569;12537572;12537573;12537574;14729961;16110336;17569856;17569867;18327897;19364924;25589440;26109356;26109357;27016737;31570835;33856346;40245499", "class_list": "", "function": "Mediates the export of the majority of mRNAs from the nucleus to the cytoplasm (PubMed:11779805, PubMed:11780633, PubMed:11780634, PubMed:27016737). In ovarian follicle cells, plays a role in transposable element silencing regulation by enabling the nuclear export of flamenco (flam) transcripts and subsequent piRNA biogenesis (PubMed:33856346)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9NFQ2;Q9NFQ3;Q9VZ65;Q9VZ68", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006406 mRNA export from nucleus;GO:0051168 nuclear export;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9U1H9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8SWU7-1", "uniprot_id": [ { "id": "OLA1_DROME", "url": "https://www.uniprot.org/uniprot/Q8SWU7", "type": "external" } ], "mass": 44910.0, "length": 397, "protein_name": "Obg-like ATPase 1", "gene_name": "Dmel\\CG1354", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform E", "refseq_ac": [ { "id": "NP_001259389", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259389", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG1354; CG1354; Dmel_CG1354", "gene_names_refseq": "CG1354; Dmel\\CG1354", "protein_names_uniprotkb": "Obg-like ATPase 1", "protein_names_refseq": "CG1354-PE; uncharacterized protein, isoform E", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1354); (R-DME-114608)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17372656;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IRM4;Q9W317", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8SWU7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VA70-1", "uniprot_id": [ { "id": "NCASE_DROME", "url": "https://www.uniprot.org/uniprot/Q9VA70", "type": "external" } ], "mass": 78232.0, "length": 704, "protein_name": "Pan-ceramidase", "gene_name": "CDase", "organism": "Fruit fly", "refseq_name": "ceramidase, isoform F", "refseq_ac": [ { "id": "NP_001263109", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263109", "type": "external" } ], "gene_names_uniprotkb": "CDase; CG1471; Cdase; Dmel\\CG1471; Dmel_CG1471; anon-WO0118547.407; cdase; fcd; slab", "gene_names_refseq": "CDase; CG1471; Cdase; Dmel\\CG1471; anon-WO0118547.407; cdase; fcd; slab", "protein_names_uniprotkb": "Pan-ceramidase; 3.5.1.23; N-CDase; NCDase; Neutral N-acylsphingosine amidohydrolase; Neutral acylsphingosine deacylase; Neutral ceramidase; Protein slug-a-bed", "protein_names_refseq": "CDase-PF; CG1471-PF; ceramidase, isoform F; ceramidase; slug-a-bed", "tax_id": 7227, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700)", "pathway": " (dme:Dmel_CG1471); (R-DME-9840310)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "10731132;12153720;12537568;12537572;12537573;12537574;12637747;14769922;15356190;16110336;17569856;17569867;18184565;21148295;25589440;26109356;26109357;40245499", "class_list": "", "function": "Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-7.5 (PubMed:15356190). Major contributor of biochemical ceramidase activity in flies; functions over a broad pH range from 5.0 to 11.0 as a pan-ceramidase (PubMed:21148295). Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface (PubMed:15356190). Regulates synaptic vesicle exocytosis and trafficking by controlling presynaptic terminal sphingolipid composition (PubMed:15356190). Functions in a cell-nonautonomous manner to suppress photoreceptor degeneration; required for the maintenance of photoreceptor homeostasis through regulation of endocytosis and apoptosis (PubMed:18184565)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q7YTD8;Q86NP1", "ec_number_list": [ { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" } ], "go_molecular_function": "GO:0017040 N-acylsphingosine amidohydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0098793 presynapse", "go_biological_process": "GO:0006665 sphingolipid metabolic process;GO:0007268 chemical synaptic transmission;GO:0046512 sphingosine biosynthetic process;GO:0046514 ceramide catabolic process;GO:0045494 photoreceptor cell maintenance", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9VA70-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9U1M2-1", "uniprot_id": [ { "id": "TM120_DROME", "url": "https://www.uniprot.org/uniprot/Q9U1M2", "type": "external" } ], "mass": 45487.0, "length": 387, "protein_name": "Transmembrane protein 120 homolog", "gene_name": "CG2716", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform D", "refseq_ac": [ { "id": "NP_001245509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245509", "type": "external" } ], "gene_names_uniprotkb": "CG2716; CG2766; CG32795; Dmel\\CG32795; Dmel_CG32795; EG:BACN33B1.2", "gene_names_refseq": "CG2716; CG2766; CG32795; Dmel\\CG32795; EG:BACN33B1.2", "protein_names_uniprotkb": "Transmembrane protein 120 homolog", "protein_names_refseq": "CG32795-PD; uncharacterized protein, isoform D", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32795)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;10731137;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0KHW4;Q9W4V5;Q9W4V6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0045089 positive regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9U1M2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q960Z0-1", "uniprot_id": [ { "id": "KI10A_DROME", "url": "https://www.uniprot.org/uniprot/Q960Z0", "type": "external" } ], "mass": 88672.0, "length": 805, "protein_name": "Kinesin-like protein Klp10A", "gene_name": "Klp10A", "organism": "Fruit fly", "refseq_name": "Kinesin-like protein at 10A, isoform F", "refseq_ac": [ { "id": "NP_001285109", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285109", "type": "external" } ], "gene_names_uniprotkb": "Klp10A; CG1453; C; DmCG1453; DmKLP10A; DmKlp10A; Dmel\\CG1453; Dmel_CG1453; KIF 2A; KLP10A; KLP10a; Kif2A; anon-WO03040301.142; klp10A; klp10a", "gene_names_refseq": "CG1453; DmCG1453; DmKLP10A; DmKlp10A; Dmel\\CG1453; KIF 2A; KIF2A/B/C; KLP10A; KLP10a; Kif2A; Klp10A; anon-WO03040301.142; klp10A; klp10a", "protein_names_uniprotkb": "Kinesin-like protein Klp10A; Kinesin-like protein at cytological position 10A", "protein_names_refseq": "CG1453-PF; Kinesin-like protein at 10A, isoform F; Kinesin13B; Klp10A-PF; kinesin-13 motor; kinesin-like protein 10A; kinesin-like protein at 10A", "tax_id": 7227, "disease": "complex cortical dysplasia with other brain malformations 3 (Disease Ontology:DOID:0090134); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG1453); (R-DME-983189)", "pathway_count": 2, "publication_count": 19, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;14681690;16110336;17372656;17569856;17569867;18327897;19687256;20946984;24100293;25589440;26109356;26109357;26659188", "class_list": "", "function": "Required during anaphase to drive sister chromatid separation to promote flux by actively depolymerizing kinetochore microtubules at their pole-associated minus ends, thereby moving chromatids through a 'poleward flux' (PubMed:14681690, PubMed:20946984, PubMed:24100293). Involved in asymmetric cell division of sensory organ precursor (SOP) cells by playing a role in the asymmetric localization of Sara-expressing endosomes to the pIIa daughter cell but not to the pIIb cell. Klp98A targets Sara-expressing endosomes to the central spindle which is symmetrically arranged in early cell division. During late cytokinesis, central spindle asymmetry is generated by enrichment of Patronin on the pIIb side which protects microtubules from depolymerization by Klp10A while unprotected microtubules on the pIIa side are disassembled by Klp10A, leading to the asymmetric delivery of Sara-expressing endosomes to the pIIa daughter cell (PubMed:26659188)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity;GO:0008574 plus-end-directed microtubule motor activity", "go_cellular_component": "GO:0005828 kinetochore microtubule;GO:0055028 cortical microtubule;GO:0090619 meiotic spindle pole;GO:0000922 spindle pole;GO:0005737 cytoplasm", "go_biological_process": "GO:0070462 plus-end specific microtubule depolymerization;GO:0051301 cell division;GO:0007018 microtubule-based movement;GO:1905515 non-motile cilium assembly;GO:0051298 centrosome duplication", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q960Z0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VT70-1", "uniprot_id": [ { "id": "NDE1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VT70", "type": "external" } ], "mass": 36239.0, "length": 317, "protein_name": "Nuclear distribution protein nudE homolog", "gene_name": "nudE", "organism": "Fruit fly", "refseq_name": "nudE, isoform A", "refseq_ac": [ { "id": "NP_648373", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648373", "type": "external" } ], "gene_names_uniprotkb": "nudE; CG8104; Dmel\\CG8104; Dmel_CG8104; DnudE; NudE", "gene_names_refseq": "CG8104; Dmel\\CG8104; DnudE; NudE; nudE", "protein_names_uniprotkb": "Nuclear distribution protein nudE homolog", "protein_names_refseq": "CG8104-PA; nudE, isoform A; nudE-PA", "tax_id": 7227, "disease": "lissencephaly (Disease Ontology:DOID:0050453); lissencephaly 4 (Disease Ontology:DOID:0112235); epilepsy (Disease Ontology:DOID:1826); Rubinstein-Taybi syndrome (Disease Ontology:DOID:1933); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dme:Dmel_CG8104)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;26490864", "class_list": "", "function": "Chaperone protein with functions in nuclear localization (PubMed:26490864). Required for centrosome duplication and formation and function of the mitotic spindle (By similarity). In postmitotic neurons, acts with nudC downstream of dar1 to ensure correct positioning of the nuclei in primary dendrites and as a consequence, is required for determining multipolar neuron morphology (PubMed:26490864)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95RM2", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule;GO:0030424 axon", "go_biological_process": "GO:0007060 male meiosis chromosome segregation;GO:0007059 chromosome segregation;GO:0007409 axonogenesis;GO:0016477 cell migration;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VT70-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VYB7-1", "uniprot_id": [ { "id": "TPST_DROME", "url": "https://www.uniprot.org/uniprot/Q9VYB7", "type": "external" } ], "mass": 58050.0, "length": 499, "protein_name": "Protein-tyrosine sulfotransferase", "gene_name": "Tpst", "organism": "Fruit fly", "refseq_name": "tyrosylprotein sulfotransferase, isoform C", "refseq_ac": [ { "id": "NP_001096973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096973", "type": "external" } ], "gene_names_uniprotkb": "Tpst; CG1573; CG15758; CG15759; CG32629; CG32632; DmTPST; Dmel\\CG32632; Dmel_CG32632; TANGO13; TPST; Tango13", "gene_names_refseq": "CG1573; CG15758; CG15759; CG32629/CG32632; CG32629; CG32632; DmTPST; Dmel\\CG32632; TANGO13; TPST; Tango13; Tpst", "protein_names_uniprotkb": "Protein-tyrosine sulfotransferase; 2.8.2.20; Tango-13; Transport and Golgi organization protein 13; Tyrosylprotein sulfotransferase", "protein_names_refseq": "CG32632-PC; Tpst-PC; transport and golgi organization 13; tyrosylprotein sulfotransferase, isoform C; tyrosylprotein sulfotransferase", "tax_id": 7227, "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861)", "pathway": " (dme:Dmel_CG32632)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;16452979;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides (By similarity). Has a role in protein secretion., [UniProtKB, UniProtKB, PubMed]; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q58CJ7;Q8MM59", "ec_number_list": [ { "id": "2.8.2.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.20", "type": "external" } ], "go_molecular_function": "GO:0008476 protein-tyrosine sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0009306 protein secretion", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VYB7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VXE6-1", "uniprot_id": [ { "id": "NU153_DROME", "url": "https://www.uniprot.org/uniprot/Q9VXE6", "type": "external" } ], "mass": 196585.0, "length": 1883, "protein_name": "Nuclear pore complex protein Nup153", "gene_name": "Nup153", "organism": "Fruit fly", "refseq_name": "nucleoporin 153kD, isoform C", "refseq_ac": [ { "id": "NP_001138206", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138206", "type": "external" } ], "gene_names_uniprotkb": "Nup153; CG4453; Dmel\\CG4453; Dmel_CG4453; NUP153; Nup 153; dNup153; dmNup153; nup153", "gene_names_refseq": "CG4453; Dmel\\CG4453; NUP153; Nup 153; Nup153; dNup153; dmNup153; nup153", "protein_names_uniprotkb": "Nuclear pore complex protein Nup153; 153 kDa nucleoporin; Nucleoporin Nup153", "protein_names_refseq": "CG4453-PC; Nup153-PC; nucleoporin 153kD, isoform C; nucleoporin 153", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4453); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236); (R-DME-1855170); (R-DME-1855196); (R-DME-1855229); (R-DME-3108214); (R-DME-3301854); (R-DME-3371453); (R-DME-4085377); (R-DME-4551638); (R-DME-4615885)", "pathway_count": 14, "publication_count": 22, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;16543150;17569856;17569867;17682050;18562695;20174442;20547758;25589440;26109356;26109357;26502056;28604694;33925313;40245499;7641726", "class_list": "", "function": "Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (PubMed:17682050). Functions as a scaffolding element in the nuclear phase of the NPC (PubMed:17682050). Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in a Importin alpha/Importin beta receptor-dependent manner (PubMed:17682050). Required for nuclear import of Mad (PubMed:20547758). Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment (PubMed:20174442). Binds chromatin to nucleoporin-associated regions (NARs) that define transcriptionally active regions of the genome (PubMed:20174442). Associates with extended chromosomal regions that alternate between domains of high density binding with those of low occupancy (PubMed:20174442). Preferentially binds to NARs of the male X chromosome (PubMed:20174442). In males, together with Mgtor, required for the localization of the male-specific lethal (MSL) histone acetyltransferase complex to the X chromosome and therefore for the transcription of dosage compensation genes (PubMed:16543150). May play a role in double strand break DNA repair (PubMed:26502056)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 38, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 38, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 38, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 40, "binding_glycan_count": 0, "secondary_ac_list": "Q1LZ48", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031490 chromatin DNA binding;GO:0017056 structural constituent of nuclear pore;GO:0008139 nuclear localization sequence binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005819 spindle;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006999 nuclear pore organization;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006913 nucleocytoplasmic transport;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 6.2, "record_id": "Q9VXE6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7PLP5-1", "uniprot_id": [ { "id": "Q7PLP5_DROME", "url": "https://www.uniprot.org/uniprot/Q7PLP5", "type": "external" } ], "mass": 124525.0, "length": 1124, "protein_name": "Rabankyrin-5", "gene_name": "BEST:GM10035; Dmel\\CG41099; GM10035", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": [ { "id": "NP_001015359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015359", "type": "external" } ], "gene_names_uniprotkb": "BEST:GM10035; Dmel\\CG41099; GM10035; BEST:GM10035; CG17416; CG17419; CG41099; Dmel\\CG41099; Dmel_CG41099; FBgn0039955; GM10035; Rabankyrin", "gene_names_refseq": "BEST:GM10035; CG17416; CG17419; CG41099; Dmel\\CG41099; FBgn0039955; GM10035; Rabankyrin", "protein_names_uniprotkb": "Rabankyrin-5", "protein_names_refseq": "CG41099-PC; D-Rabankyrin; Rabankyrin-5; rabankyrin; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "Charlevoix-Saguenay spastic ataxia (Disease Ontology:DOID:0050946)", "pathway": " (dme:Dmel_CG41099)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005773 vacuole", "go_biological_process": "GO:0006897 endocytosis;GO:0048598 embryonic morphogenesis;GO:0003382 epithelial cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7PLP5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V7N5-1", "uniprot_id": [ { "id": "VATC_DROME", "url": "https://www.uniprot.org/uniprot/Q9V7N5", "type": "external" } ], "mass": 92390.0, "length": 836, "protein_name": "V-type proton ATPase subunit C", "gene_name": "Vha44", "organism": "Fruit fly", "refseq_name": "vacuolar H[+] ATPase 44kD subunit, isoform F", "refseq_ac": [ { "id": "NP_001137679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137679", "type": "external" } ], "gene_names_uniprotkb": "Vha44; 6072; ATP6V1C1; ATP6V1C; CG8048; Dmel\\CG8048; Dmel_CG8048; l(2)02836a; l(2)02836; l(2)06072; l(2)6072; l(2)SH1339; l(2)SH2 1339; vha44", "gene_names_refseq": "6072; ATP6V1C1; ATP6V1C; CG8048; Dmel\\CG8048; Vha44; l(2)02836a; l(2)02836; l(2)6072; l(2)SH1339; l(2)SH2 1339; vha44", "protein_names_uniprotkb": "V-type proton ATPase subunit C; V-ATPase subunit C; Vacuolar proton pump subunit C", "protein_names_refseq": "CG8048-PF; V-ATPase C subunit; Vha44-PF; lethal (2) 02836a; lethal (2) SH1339; vacuolar ATPase C-subunit; vacuolar H+ ATPase 44kD C subunit; vacuolar H[+] ATPase 44 kDa subunit; vacuolar H[+] ATPase 44kD C subunit; vacuolar H[+] ATPase 44kD subunit, isoform F", "tax_id": 7227, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); cancer (Disease Ontology:DOID:162); stomach carcinoma (Disease Ontology:DOID:5517)", "pathway": " (dme:Dmel_CG8048); (R-DME-1222556); (R-DME-77387); (R-DME-917977); (R-DME-9639288); (R-DME-983712)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;32269334;9584098", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity (By similarity). In enterocytes, acts as part of a pHCl-2 sensory pathway which mediates Tor-dependent larval growth and metabolism in response to zinc availability (PubMed:32269334). Likely acts in maintaining enterocyte lysosomal acidification which consequently promotes Tor activation at the lysosome membrane (PubMed:32269334)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O18365;Q0E956;Q5U1B8;Q869C0;Q95RY7;Q9V7N6;Q9V7N7", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0033181 plasma membrane proton-transporting V-type ATPase complex;GO:0033180 proton-transporting V-type ATPase, V1 domain", "go_biological_process": "GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9V7N5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V4L4-1", "uniprot_id": [ { "id": "KBRAS_DROME", "url": "https://www.uniprot.org/uniprot/Q9V4L4", "type": "external" } ], "mass": 22807.0, "length": 201, "protein_name": "NF-kappa-B inhibitor-interacting Ras-like protein", "gene_name": "kappaB-Ras", "organism": "Fruit fly", "refseq_name": "kappaB-Ras, isoform B", "refseq_ac": [ { "id": "NP_001137613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137613", "type": "external" } ], "gene_names_uniprotkb": "kappaB-Ras; B7YZS7; BcDNA:RH38596; CG1669; Dmel\\CG1669; Dmel_CG1669; Q9V4L4-1; dkappaB-Ras", "gene_names_refseq": "B7YZS7; BcDNA:RH38596; CG1669; Dmel\\CG1669; Q9V4L4-1; dkappaB-Ras; kappaB-Ras", "protein_names_uniprotkb": "NF-kappa-B inhibitor-interacting Ras-like protein; Kappa B-Ras; KappaB-Ras", "protein_names_refseq": "CG1669-PB; kappaB-Ras, isoform B; kappaB-Ras-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1669); (R-DME-1810476); (R-DME-445989); (R-DME-933542)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10657303;10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Atypical Ras-like protein that may act as a regulator of NF-kappa-B activity, possibly by preventing the degradation of NF-kappa-B inhibitor cactus., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86P69;Q9NH91", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0032794 GTPase activating protein binding;GO:0106137 IkappaB kinase complex binding", "go_cellular_component": "", "go_biological_process": "GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0032484 Ral protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9V4L4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VJJ7-1", "uniprot_id": [ { "id": "TRPG_DROME", "url": "https://www.uniprot.org/uniprot/Q9VJJ7", "type": "external" } ], "mass": 127109.0, "length": 1128, "protein_name": "Transient receptor potential-gamma protein", "gene_name": "Trpgamma", "organism": "Fruit fly", "refseq_name": "transient receptor potential cation channel gamma, isoform A", "refseq_ac": [ { "id": "NP_609802", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609802", "type": "external" } ], "gene_names_uniprotkb": "Trpgamma; CG5996; DmTRPgamma; Dmel\\CG5996; Dmel_CG5996; TRPgamma; Trp-gamma; dTRPgamma; dTRPg; trp-gamma; trpgamma", "gene_names_refseq": "CG5996; DmTRPgamma; Dmel\\CG5996; TRPgamma; Trp-gamma; Trpgamma; dTRPgamma; dTRPg; trp-gamma; trpgamma", "protein_names_uniprotkb": "Transient receptor potential-gamma protein; TRPgamma; Transient receptor potential cation channel gamma", "protein_names_refseq": "CG5996-PA; Trpgamma-PA; transient receptor potential cation channel gamma, isoform A; trpgamma", "tax_id": 7227, "disease": "nicotine dependence (Disease Ontology:DOID:0050742); autism spectrum disorder (Disease Ontology:DOID:0060041); dilated cardiomyopathy 1H (Disease Ontology:DOID:0110429); stomach cancer (Disease Ontology:DOID:10534); lung cancer (Disease Ontology:DOID:1324); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dme:Dmel_CG5996); (R-DME-3295583); (R-DME-5578775); (R-DME-983695)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10731132;10896160;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction (By similarity). Forms a regulated cation channel when heteromultimerized with trpl., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V0S8;Q9N6L1", "ec_number_list": [], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005262 calcium channel activity;GO:0005261 monoatomic cation channel activity;GO:0008381 mechanosensitive monoatomic ion channel activity;GO:0015279 store-operated calcium channel activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:1990635 proximal dendrite;GO:0016028 rhabdomere", "go_biological_process": "GO:0006816 calcium ion transport;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0006812 monoatomic cation transport;GO:0007628 adult walking behavior;GO:0070588 calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VJJ7-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VVX3-1", "uniprot_id": [ { "id": "FRIZ2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VVX3", "type": "external" } ], "mass": 75451.0, "length": 694, "protein_name": "Frizzled-2", "gene_name": "fz2", "organism": "Fruit fly", "refseq_name": "frizzled 2, isoform C", "refseq_ac": [ { "id": "NP_001097643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097643", "type": "external" } ], "gene_names_uniprotkb": "fz2; CG9739; D-Fz2; D-fz2; DFZ2; DFz-2; DFz2C; DFz2; Dfrz2; Dfz2; Dfz[[2]]; Dm Fz2; Dmel\\CG9739; Dmel_CG9739; FZ2; Frizzled 2; Fz2R; Fz2; dFz2; dfz(2); dfz2r; dfz2; frz2; fz-2", "gene_names_refseq": "CG9739; D-Fz2; D-fz2; DFZ2; DFz-2; DFz2C; DFz2; Dfrz2; Dfz2; Dfz[[2]]; Dm Fz2; Dmel\\CG9739; FZ2; Frizzled 2; Fz2R; Fz2; dFz2; dfz(2); dfz2r; dfz2; frz2; fz-2; fz2", "protein_names_uniprotkb": "Frizzled-2; dFz2", "protein_names_refseq": "CG9739-PC; D-frizzled2; DFrizzled2; Dfrizzled[[2]]; dfrizzled 2; drosophila frizzled 2; drosophila frizzled2; frizzled 2, isoform C; frizzled-2; fz2-PC", "tax_id": 7227, "disease": "coloboma (Disease Ontology:DOID:12270)", "pathway": " (dme:Dmel_CG9739); (R-DME-209387); (R-DME-209440); (R-DME-209472); (R-DME-4608870); (R-DME-5140745)", "pathway_count": 6, "publication_count": 28, "publication_id_list": "10097073;10196136;10421629;10731132;10846164;10949033;11336703;12205098;12537568;12537572;12537573;12537574;12636921;12781135;14636582;14731402;15459103;16110336;16163385;16341016;16987508;17569856;17569867;20579883;25589440;26109356;26109357;8717036", "class_list": "", "function": "Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A8JNV7;Q494J1;Q94916;Q9VVX2", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0030165 PDZ domain binding;GO:0017147 Wnt-protein binding;GO:0042813 Wnt receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:1990909 Wnt signalosome;GO:1990851 Wnt-Frizzled-LRP5/6 complex", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0016477 cell migration;GO:0050808 synapse organization;GO:0007494 midgut development;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.9, "record_id": "Q9VVX3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VW27-1", "uniprot_id": [ { "id": "TEY_DROME", "url": "https://www.uniprot.org/uniprot/Q9VW27", "type": "external" } ], "mass": 76716.0, "length": 717, "protein_name": "Protein Teyrha-meyrha", "gene_name": "tey", "organism": "Fruit fly", "refseq_name": "teyrha-meyrha, isoform A", "refseq_ac": [ { "id": "NP_649140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649140", "type": "external" } ], "gene_names_uniprotkb": "tey; CG8780; Dmel\\CG8780; Dmel_CG8780; Tey", "gene_names_refseq": "CG8780; Dmel\\CG8780; Tey; tey", "protein_names_uniprotkb": "Protein Teyrha-meyrha", "protein_names_refseq": "CG8780-PA; tey-PA; teyrha meyrha; teyrha-meyhra; teyrha-meyrha, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8780)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17028348;17569856;17569867;20504957;25589440;26109356;26109357", "class_list": "", "function": "Required for the correct synaptic targeting of motoneurons RP5 and V to muscle 12 (M12) (PubMed:20504957). May be involved in the negative regulation of Tl in M12 (PubMed:20504957). Involved in the correct patterning of veins in the proximal (costal) region of the wing blade (PubMed:17028348)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045892 negative regulation of DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0008039 synaptic target recognition", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VW27-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VNX8-1", "uniprot_id": [ { "id": "EIF2A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VNX8", "type": "external" } ], "mass": 70071.0, "length": 638, "protein_name": "Eukaryotic translation initiation factor 2A", "gene_name": "eIF2A", "organism": "Fruit fly", "refseq_name": "eukaryotic translation initiation factor 2A, isoform D", "refseq_ac": [ { "id": "NP_001137996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137996", "type": "external" } ], "gene_names_uniprotkb": "eIF2A; CG7414; Dmel\\CG7414; Dmel_CG7414; EIF2A; anon-WO0118547.243; dEIF2A", "gene_names_refseq": "CG7414; Dmel\\CG7414; EIF2A; anon-WO0118547.243; dEIF2A; eIF2A", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2A; eIF-2A", "protein_names_refseq": "CG7414-PD; eIF2A-PD; eukaryotic translation initiation factor 2A, isoform D", "tax_id": 7227, "disease": "borna disease (Disease Ontology:DOID:5154)", "pathway": " (dme:Dmel_CG7414)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0000049 tRNA binding;GO:0043022 ribosome binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005850 eukaryotic translation initiation factor 2 complex", "go_biological_process": "GO:0006417 regulation of translation;GO:0006413 translational initiation;GO:0007291 sperm individualization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VNX8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VC99-1", "uniprot_id": [ { "id": "UCK_DROME", "url": "https://www.uniprot.org/uniprot/Q9VC99", "type": "external" } ], "mass": 29213.0, "length": 260, "protein_name": "Uridine-cytidine kinase", "gene_name": "Uck", "organism": "Fruit fly", "refseq_name": "Uridine-cytidine kinase, isoform D", "refseq_ac": [ { "id": "NP_001247281", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247281", "type": "external" } ], "gene_names_uniprotkb": "Uck; CG6364; CR42873; Dmel\\CG6364; Dmel_CG6364; Uck2", "gene_names_refseq": "CG6364; CR42873; Dmel\\CG6364; Uck2; Uck", "protein_names_uniprotkb": "Uridine-cytidine kinase; 2.7.1.48; Cytidine monophosphokinase; UCK; Uridine monophosphokinase", "protein_names_refseq": "CG6364-PD; Uck-PD; Uridine-cytidine kinase, isoform D", "tax_id": 7227, "disease": "pancreatic cancer (Disease Ontology:DOID:1793); nerve compression syndrome (Disease Ontology:DOID:573)", "pathway": " (dme:Dmel_CG6364); (R-DME-73614)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;22851751;23306065;25589440;26109356;26109357", "class_list": "", "function": "(Microbial infection) Required for optimal replication of E.chaffeensis in the immune tissues, hemocytes, and fat body., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "H1UUH6", "ec_number_list": [ { "id": "2.7.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.48", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004849 uridine kinase activity;GO:0043771 cytidine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0044206 UMP salvage;GO:0044211 CTP salvage", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VC99-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VEU6-1", "uniprot_id": [ { "id": "GCYDA_DROME", "url": "https://www.uniprot.org/uniprot/Q9VEU6", "type": "external" } ], "mass": 76146.0, "length": 667, "protein_name": "Soluble guanylate cyclase 89Da", "gene_name": "Gyc89Da", "organism": "Fruit fly", "refseq_name": "guanylyl cyclase at 89Da, isoform C", "refseq_ac": [ { "id": "NP_001036718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036718", "type": "external" } ], "gene_names_uniprotkb": "Gyc89Da; CG14885; Dmel\\CG14885; Dmel_CG14885; GYCb; Gyc-89Da", "gene_names_refseq": "CG14885; Dmel\\CG14885; GYCb; Gyc-89Da; Gyc89Da", "protein_names_uniprotkb": "Soluble guanylate cyclase 89Da; 4.6.1.2", "protein_names_refseq": "CG14885-PC; Gyc89Da-PC; guanylyl cyclase at 89Da, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14885)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;15159437;15485853;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Heterodimers with Gyc-89Da and Gyc-89Db are activated in response to changing oxygen concentrations, alerting flies to hypoxic environments. Under normal oxygen concentrations, oxygen binds to the heme group and results in low levels of guanylyl cyclase activity. When exposed to reduced oxygen concentrations, the oxygen dissociates from the heme group resulting in activation of the enzyme., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0KI63;Q4V501", "ec_number_list": [ { "id": "4.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0005525 GTP binding;GO:0019899 enzyme binding;GO:0046872 metal ion binding;GO:0020037 heme binding", "go_cellular_component": "GO:0008074 guanylate cyclase complex, soluble", "go_biological_process": "GO:0001666 response to hypoxia;GO:0000302 response to reactive oxygen species;GO:0038060 nitric oxide-cGMP-mediated signaling;GO:0070482 response to oxygen levels", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VEU6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VHY5-1", "uniprot_id": [ { "id": "TAF7_DROME", "url": "https://www.uniprot.org/uniprot/Q9VHY5", "type": "external" } ], "mass": 55065.0, "length": 479, "protein_name": "Transcription initiation factor TFIID subunit 7", "gene_name": "Taf7", "organism": "Fruit fly", "refseq_name": "TBP-associated factor 7, isoform A", "refseq_ac": [ { "id": "NP_649748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649748", "type": "external" } ], "gene_names_uniprotkb": "Taf7; CG2670; Dmel\\CG2670; Dmel_CG2670; E; TAF55; TAF7; TAF[[II]]55; TAF[[II]]; TAF; TFIID; Taf55; anon-84Ec; dTAF[[II]]55; taf7", "gene_names_refseq": "CG2670; Dmel\\CG2670; E; TAF55; TAF7; TAF[[II]]55; TAF[[II]]; TAF; TFIID; Taf55; Taf7; anon-84Ec; dTAF[[II]]55; taf7", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 7; TAFII-55; TAFII55; Transcription initiation factor TFIID 55 kDa subunit", "protein_names_refseq": "CG2670-PA; TBP-associated factor 55kD; TBP-associated factor 7, isoform A; Taf7-PA", "tax_id": 7227, "disease": "oligospermia (Disease Ontology:DOID:14228)", "pathway": " (dme:Dmel_CG2670); (R-DME-674695); (R-DME-6804756); (R-DME-73776); (R-DME-73779); (R-DME-75953); (R-DME-76042)", "pathway_count": 7, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;9601978", "class_list": "", "function": "TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O76207;Q8T087", "ec_number_list": [], "go_molecular_function": "GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VHY5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VI13-1", "uniprot_id": [ { "id": "PAK_DROME", "url": "https://www.uniprot.org/uniprot/Q9VI13", "type": "external" } ], "mass": 76187.0, "length": 704, "protein_name": "Serine/threonine-protein kinase Pak", "gene_name": "Pak", "organism": "Fruit fly", "refseq_name": "p21-activated kinase, isoform E", "refseq_ac": [ { "id": "NP_001262309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262309", "type": "external" } ], "gene_names_uniprotkb": "Pak; CG10295; D-Pak; DPAK; DPak1; DPak; DmPAK1; Dmel\\CG10295; Dmel_CG10295; Dpak1; Dpak; PAK-1; PAK1; PAK2; PAK; PaK; Pak1; dPAK1; dPAK; dPak; dpak1; dpak; l(3)psg4; p65[PAK]; pak1; pak; psg4", "gene_names_refseq": "CG10295; D-Pak; DPAK; DPak1; DPak; DmPAK1; Dmel\\CG10295; Dpak1; Dpak; PAK-1; PAK1; PAK2; PAK; PaK; Pak1; Pak; dPAK1; dPAK; dPak; dpak1; dpak; l(3)psg4; p65[PAK]; pak1; pak; psg4", "protein_names_uniprotkb": "Serine/threonine-protein kinase Pak; 2.7.11.1", "protein_names_refseq": "CG10295-PE; P21-activated kinase; P21-activating kinase; PAK kinase; PAK-kinase; Pak-PE; Pak1 kinase; lethal (3) persistent salivary gland 4; p-21 activated kinase; p21 activated kinase; p21- activated kinase; p21-activated kinase, isoform E; p21-activated serine/threonine kinase; p21-associated kinase", "tax_id": 7227, "disease": "stroke (Disease Ontology:DOID:0051061); autism spectrum disorder (Disease Ontology:DOID:0060041); ductal carcinoma in situ (Disease Ontology:DOID:0060074); non-syndromic X-linked intellectual disability 30 (Disease Ontology:DOID:0112051); Alzheimer's disease (Disease Ontology:DOID:10652); breast cancer (Disease Ontology:DOID:1612); nephroblastoma (Disease Ontology:DOID:2154); brain ischemia (Disease Ontology:DOID:2316); transitional cell carcinoma (Disease Ontology:DOID:2671); ovarian carcinoma (Disease Ontology:DOID:4001); renal cell carcinoma (Disease Ontology:DOID:4450); ureteral obstruction (Disease Ontology:DOID:5199); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dme:Dmel_CG10295); (R-DME-2029482); (R-DME-2871796); (R-DME-389359); (R-DME-3928662); (R-DME-3928664); (R-DME-445144); (R-DME-5218920); (R-DME-5621575); (R-DME-5627123); (R-DME-5687128); (R-DME-8964616); (R-DME-9013149); (R-DME-9013406); (R-DME-9013407); (R-DME-9013420); (R-DME-9013423); (R-DME-9013424)", "pathway_count": 18, "publication_count": 16, "publication_id_list": "10399914;10731132;10892653;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18996366;25589440;26109356;26109357;8628256", "class_list": "", "function": "Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. May be required for the formation of dendritic spines and excitatory synapses (By similarity). During muscle embryogenesis, promotes proper muscle morphogenesis, as well as guidance and targeting of subsets of myotubes (PubMed:18996366). In the developing eye, required for guidance and targeting of photoreceptor (R cell) axon projections but not for axon outgrowth, differentiation or target induction (PubMed:10399914). Is recruited to membranes by dock/dreadlocks, probably when dock/dreadlocks is associated with activated receptors (PubMed:10399914)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q24190;Q24213", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0017124 SH3 domain binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005925 focal adhesion;GO:0030426 growth cone", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0007155 cell adhesion;GO:0016477 cell migration;GO:0035556 intracellular signal transduction;GO:0050803 regulation of synapse structure or activity", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9VI13-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VAJ4-1", "uniprot_id": [ { "id": "OB99A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VAJ4", "type": "external" } ], "mass": 15995.0, "length": 142, "protein_name": "General odorant-binding protein 99a", "gene_name": "Obp99a", "organism": "Fruit fly", "refseq_name": "Odorant-binding protein 99a, isoform B", "refseq_ac": [ { "id": "NP_001287586", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287586", "type": "external" } ], "gene_names_uniprotkb": "Obp99a; 99a; BcDNA:RH70762; CG18111; DmelObp99a; Dmel\\CG18111; Dmel_CG18111; OBP99A; OBP99a; obp99a", "gene_names_refseq": "99a; BcDNA:RH70762; CG18111; DmelObp99a; Dmel\\CG18111; OBP99A; OBP99a; Obp99a; obp99a", "protein_names_uniprotkb": "General odorant-binding protein 99a", "protein_names_refseq": "CG18111-PB; Obp99a-PB; Odorant-binding protein 99a, isoform B; odorant binding protein 99a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18111)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;11729153;12505997;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;17720903;25589440;26109356;26109357", "class_list": "", "function": "Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9QIH3;A9QII9;A9QIJ4;A9QIU5", "ec_number_list": [], "go_molecular_function": "GO:0005549 odorant binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0012505 endomembrane system", "go_biological_process": "GO:0042048 olfactory behavior;GO:0007608 sensory perception of smell;GO:0019236 response to pheromone;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VAJ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7PLL6-1", "uniprot_id": [ { "id": "Q7PLL6_DROME", "url": "https://www.uniprot.org/uniprot/Q7PLL6", "type": "external" } ], "mass": 293910.0, "length": 2630, "protein_name": "Lethal (3) 80Fj, isoform A", "gene_name": "l(3)80Fj", "organism": "Fruit fly", "refseq_name": "lethal (3) 80Fj, isoform A", "refseq_ac": [ { "id": "NP_001015316", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015316", "type": "external" } ], "gene_names_uniprotkb": "l(3)80Fj; 80Fj; CG17514; Dmel\\CG17514; Dmel_CG17514; l(3)Lh1; l1; lethal 1", "gene_names_refseq": "80Fj; CG17514; Dmel\\CG17514; l(3)80Fj; l(3)Lh1; l1; lethal 1", "protein_names_uniprotkb": "Lethal (3) 80Fj, isoform A", "protein_names_refseq": "CG17514-PA; l(3)80Fj-PA; lethal (3) 80Fj, isoform A; lethal 1; lethal1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17514)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019887 protein kinase regulator activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006417 regulation of translation;GO:0000226 microtubule cytoskeleton organization;GO:0034198 cellular response to amino acid starvation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7PLL6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MLV9-1", "uniprot_id": [ { "id": "Q8MLV9_DROME", "url": "https://www.uniprot.org/uniprot/Q8MLV9", "type": "external" } ], "mass": 31003.0, "length": 277, "protein_name": "Peptidase S1 domain-containing protein", "gene_name": "Dmel\\CG30286; SP37", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_726082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_726082", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG30286; SP37; CG10450; CG30286; Dmel\\CG30286; Dmel_CG30286; SP223; SP37; SPH37", "gene_names_refseq": "CG10450; CG30286; Dmel\\CG30286; SP223; SP37; SPH37", "protein_names_uniprotkb": "Peptidase S1 domain-containing protein", "protein_names_refseq": "CG30286-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG30286)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8MLV9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7K3L1-1", "uniprot_id": [ { "id": "MARS_DROME", "url": "https://www.uniprot.org/uniprot/Q7K3L1", "type": "external" } ], "mass": 101946.0, "length": 921, "protein_name": "Guanylate kinase-associated protein mars", "gene_name": "mars", "organism": "Fruit fly", "refseq_name": "mars, isoform B", "refseq_ac": [ { "id": "NP_001163142", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163142", "type": "external" } ], "gene_names_uniprotkb": "mars; CG17064; D-HURP; Dmel\\CG17064; Dmel_CG17064; HURP; Mars; d-hurp; gkap", "gene_names_refseq": "CG17064; D-HURP; Dmel\\CG17064; HURP; Mars; d-hurp; dhrp/gkap; gkap; mars", "protein_names_uniprotkb": "Guanylate kinase-associated protein mars", "protein_names_refseq": "CG17064-PB; mars, isoform B; mars-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17064)", "pathway_count": 1, "publication_count": 17, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15261830;15922738;16110336;17372656;17569856;17569867;18327897;25589440;26109356;26109357;40245499", "class_list": "", "function": "Cell cycle regulator., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0008157 protein phosphatase 1 binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0007059 chromosome segregation;GO:0007346 regulation of mitotic cell cycle;GO:0023052 signaling;GO:0007051 spindle organization", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q7K3L1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IPJ3-1", "uniprot_id": [ { "id": "LUBEL_DROME", "url": "https://www.uniprot.org/uniprot/Q8IPJ3", "type": "external" } ], "mass": 320914.0, "length": 2892, "protein_name": "E3 ubiquitin-protein ligase lubel", "gene_name": "LUBEL", "organism": "Fruit fly", "refseq_name": "linear ubiquitin E3 ligase, isoform F", "refseq_ac": [ { "id": "NP_001260156", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260156", "type": "external" } ], "gene_names_uniprotkb": "LUBEL; AAF52435.2; CG11321; Dmel\\CG11321; Dmel_CG11321; Lubel; lubel", "gene_names_refseq": "AAF52435.2; CG11321; Dmel\\CG11321; LUBEL; Lubel; lubel", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase lubel; 2.3.2.31; Linear Ubiquitin E3 ligase", "protein_names_refseq": "CG11321-PF; LUBEL-PF; linear ubiquitin E3 ligase, isoform F", "tax_id": 7227, "disease": "immunodeficiency 115 (Disease Ontology:DOID:0061081)", "pathway": " (dme:Dmel_CG11321)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;27702987;30026495", "class_list": "", "function": "E3 ubiquitin-protein ligase which conjugates linear 'Met-1'- and 'Lys-63'-linked polyubiquitin chains to substrates and plays a crucial role in the NF-kappa-B intestinal inflammatory response to oral infection and in the heat stress response (PubMed:27702987, PubMed:30026495). Preferentially interacts with 'Lys-63'-linked, and to a lesser extent 'Lys-48'-linked, polyubiquitin chains (PubMed:27702987). Upon oral infection with a Gram-negative bacterium E.carotovora subsp. carotovora 15, functions with the E2 ubiquitin-conjugating enzyme Ubc10 to mediate the conjugation of 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains to the substrate key which is essential for activation of the NF-kappa-B signaling cascade in the adult intestinal epithelium (PubMed:27702987, PubMed:30026495). It is not required for systemic immune response to septic infection with either E.carotovora subsp. carotovora 15 or Gram-positive M.luteus bacteria (PubMed:30026495). Function in controlling linear ubiquitination is also essential for regulating the heat stress response in adults. This function may require the E2 ubiquitin-conjugating enzymes Ubc10 or eff (PubMed:27702987)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 12, "predicted_n_glycosites": 0, "predicted_o_glycosites": 12, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "M9PB55;M9PCD7;M9PCS0;Q9VM88", "ec_number_list": [], "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0071797 LUBAC complex", "go_biological_process": "GO:0097039 protein linear polyubiquitination;GO:0050829 defense response to Gram-negative bacterium;GO:0000209 protein polyubiquitination;GO:0002376 immune system process;GO:0010286 heat acclimation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8IPJ3-1", "record_type": "protein", "filter_code": "0000000.0100111.001000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VK68-1", "uniprot_id": [ { "id": "PITH1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VK68", "type": "external" } ], "mass": 23917.0, "length": 211, "protein_name": "PITH domain-containing protein CG6153", "gene_name": "6153", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": [ { "id": "NP_001162966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162966", "type": "external" } ], "gene_names_uniprotkb": "6153; CG6153; Dmel\\CG6153; Dmel_CG6153", "gene_names_refseq": "6153; CG6153; Dmel\\CG6153", "protein_names_uniprotkb": "PITH domain-containing protein CG6153", "protein_names_refseq": "CG6153-PC; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6153)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7K2H3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0045654 positive regulation of megakaryocyte differentiation;GO:0080090 regulation of primary metabolic process;GO:0060255 regulation of macromolecule metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VK68-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VIF3-1", "uniprot_id": [ { "id": "Q9VIF3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VIF3", "type": "external" } ], "mass": 34379.0, "length": 310, "protein_name": "Ubiquinone biosynthesis O-methyltransferase, mitochondrial", "gene_name": "Coq3", "organism": "Fruit fly", "refseq_name": "coenzyme Q3, isoform A", "refseq_ac": [ { "id": "NP_610092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610092", "type": "external" } ], "gene_names_uniprotkb": "Coq3; CG9249; Dmel\\CG9249; Dmel_CG9249", "gene_names_refseq": "CG9249; Coq3; Dmel\\CG9249", "protein_names_uniprotkb": "Ubiquinone biosynthesis O-methyltransferase, mitochondrial; 2.1.1.-; 2.1.1.114; 2.1.1.64; 3-demethylubiquinol 3-O-methyltransferase; 3-demethylubiquinone 3-O-methyltransferase; Polyprenyldihydroxybenzoate methyltransferase", "protein_names_refseq": "CG9249-PA; Coq3-PA; coenzyme Q3, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9249); (R-DME-2142789)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.114", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.114", "type": "external" }, { "id": "2.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.64", "type": "external" }, { "id": "1.14.15.45", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.45", "type": "external" }, { "id": "1.14.15.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.46", "type": "external" }, { "id": "4.1.1.130", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.130", "type": "external" }, { "id": "2.1.1.201", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.201", "type": "external" }, { "id": "1.14.99.60", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.60", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0010420 polyprenyldihydroxybenzoate methyltransferase activity;GO:0061542 3-demethylubiquinol 3-O-methyltransferase activity;GO:0120537 3-demethylubiquinone 3-O-methyltransferase activity", "go_cellular_component": "GO:0031314 extrinsic component of mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0110142 ubiquinone biosynthesis complex", "go_biological_process": "GO:0032259 methylation;GO:0042060 wound healing;GO:0006744 ubiquinone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VIF3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W0T1-1", "uniprot_id": [ { "id": "NU301_DROME", "url": "https://www.uniprot.org/uniprot/Q9W0T1", "type": "external" } ], "mass": 300686.0, "length": 2669, "protein_name": "Nucleosome-remodeling factor subunit NURF301", "gene_name": "E(bx)", "organism": "Fruit fly", "refseq_name": "enhancer of bithorax, isoform E", "refseq_ac": [ { "id": "NP_001163304", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163304", "type": "external" } ], "gene_names_uniprotkb": "E(bx); CG10894; CG17135; CG32346; CG32478; CG7022; Dmel\\CG32346; Dmel_CG32346; E(BX); E(Bx); Ebx; En-bx; NURF 215; NURF-215; NURF-301; NURF215; NURF301; NURF; NuRF301; Nurf 301; Nurf-215; Nurf301; Nurf; dNURF301; dNURF; e(Bx); e(bx); l(3)122; l(3)ry122; nurf301; p215; p301", "gene_names_refseq": "CG10894; CG17135; CG32346; CG32478; CG7022; Dmel\\CG32346; E(BX); E(Bx); E(bx); Ebx; En-bx; NURF 215; NURF-215; NURF-301; NURF215; NURF301; NURF; NuRF301; Nurf 301; Nurf-215; Nurf301; Nurf; dNURF301; dNURF; e(Bx); e(bx); l(3)122; l(3)ry122; nurf301; p215; p301", "protein_names_uniprotkb": "Nucleosome-remodeling factor subunit NURF301; Enhancer of bithorax; NURF-215; Nucleosome-remodeling factor 215 kDa subunit", "protein_names_refseq": "CG32346-PE; E(bx)-PE; enhancer of bithorax, isoform E; nucleosome remodeling factor - 215kD; nucleosome remodeling factor", "tax_id": 7227, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); neurodevelopmental disorder with dysmorphic facies and distal limb anomalies (Disease Ontology:DOID:0070514); Alzheimer's disease (Disease Ontology:DOID:10652); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); Kaposi's sarcoma (Disease Ontology:DOID:8632)", "pathway": " (dme:Dmel_CG32346)", "pathway_count": 1, "publication_count": 21, "publication_id_list": "10731132;11583616;12502740;12537568;12537569;12537572;12537573;12537574;15952742;16110336;16264191;16728976;17569856;17569867;18327897;25589440;26109356;26109357;33925313;40245499;8521501", "class_list": "", "function": "Histone-binding component of NURF (nucleosome remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. Required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 8, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 8, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 8, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 5, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q4V464;Q7KVD8;Q95VB8;Q960Y3;Q9W0T2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0016922 nuclear receptor binding;GO:0140002 histone H3K4me3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016589 NURF complex", "go_biological_process": "GO:0034728 nucleosome organization;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 3.1, "record_id": "Q9W0T1-1", "record_type": "protein", "filter_code": "0000000.0000111.001000.000000100000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9GQF1-1", "uniprot_id": [ { "id": "JIP3_DROME", "url": "https://www.uniprot.org/uniprot/Q9GQF1", "type": "external" } ], "mass": 136712.0, "length": 1227, "protein_name": "JNK-interacting protein 3", "gene_name": "syd", "organism": "Fruit fly", "refseq_name": "sunday driver, isoform A", "refseq_ac": [ { "id": "NP_524652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524652", "type": "external" } ], "gene_names_uniprotkb": "syd; CG8110; Dmel\\CG8110; Dmel_CG8110; JIP-3; Syd; dsyd-1; jip3", "gene_names_refseq": "CG8110; Dmel\\CG8110; JIP-3; Syd; dsyd-1; jip3; syd", "protein_names_uniprotkb": "JNK-interacting protein 3; Protein sunday driver", "protein_names_refseq": "CG8110-PA; sunday driver, isoform A; sunday driver; syd-PA", "tax_id": 7227, "disease": "endometrial cancer (Disease Ontology:DOID:1380); liver cirrhosis (Disease Ontology:DOID:5082); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dme:Dmel_CG8110); (R-DME-525793)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;11106729;12537568;12537569;12537572;12537573;12537574;16110336;17018572;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK-signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Syd is required for efficient kinesin-I mediated axonal transport., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5U182;Q8IGL6;Q95SK0;Q9VSC0", "ec_number_list": [], "go_molecular_function": "GO:0019894 kinesin binding;GO:0005078 MAP-kinase scaffold activity;GO:0030159 signaling receptor complex adaptor activity;GO:0008432 JUN kinase binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0043005 neuron projection;GO:0030140 trans-Golgi network transport vesicle", "go_biological_process": "GO:0008088 axo-dendritic transport;GO:0043066 negative regulation of apoptotic process;GO:0007416 synapse assembly;GO:0050821 protein stabilization;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9GQF1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IQC1-1", "uniprot_id": [ { "id": "TVP23_DROME", "url": "https://www.uniprot.org/uniprot/Q8IQC1", "type": "external" } ], "mass": 25527.0, "length": 223, "protein_name": "Uncharacterized Golgi apparatus membrane protein-like protein CG5021", "gene_name": "Dmel\\CG5021", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": [ { "id": "NP_001163390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163390", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG5021; CG5021; Dmel_CG5021", "gene_names_refseq": "CG5021; Dmel\\CG5021", "protein_names_uniprotkb": "Uncharacterized Golgi apparatus membrane protein-like protein CG5021", "protein_names_refseq": "CG5021-PC; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5021)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SYV2;Q9VSR9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0009306 protein secretion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8IQC1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VCF0-1", "uniprot_id": [ { "id": "Y5902_DROME", "url": "https://www.uniprot.org/uniprot/Q9VCF0", "type": "external" } ], "mass": 28179.0, "length": 243, "protein_name": "Uncharacterized protein CG5902", "gene_name": "anon-WO0118547.372", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": [ { "id": "NP_001163705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163705", "type": "external" } ], "gene_names_uniprotkb": "anon-WO0118547.372; CG5902; Dmel\\CG5902; Dmel_CG5902", "gene_names_refseq": "CG5902; Dmel\\CG5902; anon-WO0118547.372", "protein_names_uniprotkb": "Uncharacterized protein CG5902", "protein_names_refseq": "CG5902-PC; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "midface hypoplasia, hearing impairment, elliptocytosis, and nephrocalcinosis (Disease Ontology:DOID:0111859)", "pathway": " (dme:Dmel_CG5902)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V3B3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VCF0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VCE8-1", "uniprot_id": [ { "id": "ACTMP_DROME", "url": "https://www.uniprot.org/uniprot/Q9VCE8", "type": "external" } ], "mass": 29224.0, "length": 267, "protein_name": "Actin maturation protease", "gene_name": "Dmel\\CG33108", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": [ { "id": "NP_788728", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788728", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG33108; BcDNA:RE26840; C19orf54Nt; CG33108; CG5926; Dmel_CG33108", "gene_names_refseq": "BcDNA:RE26840; C19orf54Nt; CG33108; CG5926; Dmel\\CG33108", "protein_names_uniprotkb": "Actin maturation protease; 3.4.11.-; Actin aminopeptidase ACTMAP", "protein_names_refseq": "CG33108-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33108)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Actin maturation protease that specifically mediates the cleavage of immature acetylated N-terminal actin, thereby contributing to actin maturation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" } ], "go_molecular_function": "GO:0070005 cysteine-type aminopeptidase activity;GO:0004239 initiator methionyl aminopeptidase activity;GO:0004177 aminopeptidase activity", "go_cellular_component": "", "go_biological_process": "GO:0016485 protein processing;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VCE8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VB98-1", "uniprot_id": [ { "id": "Y5521_DROME", "url": "https://www.uniprot.org/uniprot/Q9VB98", "type": "external" } ], "mass": 216326.0, "length": 1958, "protein_name": "Probable Rho GTPase-activating protein CG5521", "gene_name": "EP3527", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001163748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163748", "type": "external" } ], "gene_names_uniprotkb": "EP3527; CG5521; Dmel\\CG5521; Dmel_CG5521; FBpp0084441", "gene_names_refseq": "CG5521; Dmel\\CG5521; EP3527; FBpp0084441", "protein_names_uniprotkb": "Probable Rho GTPase-activating protein CG5521", "protein_names_refseq": "CG5521-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5521); (R-DME-9013407)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17372656;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q058W5", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VB98-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VYX0-1", "uniprot_id": [ { "id": "Q9VYX0_DROME", "url": "https://www.uniprot.org/uniprot/Q9VYX0", "type": "external" } ], "mass": 62490.0, "length": 544, "protein_name": "Transcription factor grauzone", "gene_name": "Dmel\\CG11695", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": [ { "id": "NP_572732", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572732", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG11695; CG11695; Dmel_CG11695", "gene_names_refseq": "CG11695; Dmel\\CG11695", "protein_names_uniprotkb": "Transcription factor grauzone", "protein_names_refseq": "CG11695-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11695)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VYX0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KNF2-1", "uniprot_id": [ { "id": "PABP2_DROME", "url": "https://www.uniprot.org/uniprot/Q7KNF2", "type": "external" } ], "mass": 24978.0, "length": 224, "protein_name": "Polyadenylate-binding protein 2", "gene_name": "Pabp2", "organism": "Fruit fly", "refseq_name": "Pabp2, isoform A", "refseq_ac": [ { "id": "NP_476902", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_476902", "type": "external" } ], "gene_names_uniprotkb": "Pabp2; CG2163; Dmel\\CG2163; Dmel_CG2163; PABP2; PABPN1; ROX2; Rox2; dpabII; pAbp2; pabp2; rox2", "gene_names_refseq": "CG2163; Dmel\\CG2163; PABP2; PABPN1; Pabp2; ROX2; Rox2; dpabII; pAbp2; pabp2; rox2", "protein_names_uniprotkb": "Polyadenylate-binding protein 2; Nuclear poly(A)-binding protein 1; PABII; PABP-2; Poly(A)-binding protein 2; Poly(A)-binding protein II; Polyadenylate-binding nuclear protein 1; Protein rox2; dPABP2", "protein_names_refseq": "CG2163-PA; Pabp2, isoform A; Pabp2-PA; nuclear poly(A)-binding protein; poly-A binding protein 2; polyA-binding protein II", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2163); (R-DME-73856); (R-DME-77595); (R-DME-9770562); (R-DME-9930044)", "pathway_count": 5, "publication_count": 17, "publication_id_list": "10481015;10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;19364924;21203496;25589440;26109356;26109357;28190776;7890163", "class_list": "", "function": "Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (PubMed:10481015). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and also controls the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Binds to poly(A) and to poly(G) with high affinity (PubMed:10481015). May protect the poly(A) tail from degradation (By similarity). Plays a role in the positive regulation of alpha-1,3 fucosylation, possibly by cooperating with swm which regulates nuclear export of fucosyltransferase FucTA (PubMed:21203496). Involved in germline stem cell transit amplification, differentiation and mitosis-to-meiosis transition (PubMed:28190776)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1Z7B1;Q27926;Q7JQ60", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008143 poly(A) binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0071013 catalytic step 2 spliceosome;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0031124 mRNA 3'-end processing;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening;GO:0180010 co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q7KNF2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7JUR5-1", "uniprot_id": [ { "id": "Y2744_DROME", "url": "https://www.uniprot.org/uniprot/Q7JUR5", "type": "external" } ], "mass": 18593.0, "length": 160, "protein_name": "Uncharacterized zinc finger protein CG12744", "gene_name": "Dmel\\CG12744", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_610530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610530", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG12744; CG12744; Dmel_CG12744", "gene_names_refseq": "CG12744; Dmel\\CG12744", "protein_names_uniprotkb": "Uncharacterized zinc finger protein CG12744", "protein_names_refseq": "CG12744-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12744)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q7JUR5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7K4H4-1", "uniprot_id": [ { "id": "NO66_DROME", "url": "https://www.uniprot.org/uniprot/Q7K4H4", "type": "external" } ], "mass": 73098.0, "length": 653, "protein_name": "Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66", "gene_name": "NO66", "organism": "Fruit fly", "refseq_name": "nucleolar protein 66, isoform B", "refseq_ac": [ { "id": "NP_572160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572160", "type": "external" } ], "gene_names_uniprotkb": "NO66; CG2982; Dmel\\CG2982; Dmel_CG2982; anon-4Bd", "gene_names_refseq": "CG2982; Dmel\\CG2982; NO66; anon-4Bd", "protein_names_uniprotkb": "Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; 1.14.11.-; 1.14.11.27; Histone lysine demethylase NO66", "protein_names_refseq": "CG2982-PB; NO66-PB; anon-4Bd; nucleolar protein 66, isoform B", "tax_id": 7227, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (dme:Dmel_CG2982); (R-DME-9629569)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17372656;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.27", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" } ], "go_molecular_function": "GO:0051864 histone H3K36 demethylase activity;GO:0034647 histone H3K4me/H3K4me2/H3K4me3 demethylase activity;GO:0032453 histone H3K4 demethylase activity;GO:0005506 iron ion binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0048149 behavioral response to ethanol;GO:0048512 circadian behavior;GO:0045471 response to ethanol", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q7K4H4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VJ79-1", "uniprot_id": [ { "id": "PDE11_DROME", "url": "https://www.uniprot.org/uniprot/Q9VJ79", "type": "external" } ], "mass": 160930.0, "length": 1451, "protein_name": "Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11", "gene_name": "Pde11", "organism": "Fruit fly", "refseq_name": "phosphodiesterase 11, isoform C", "refseq_ac": [ { "id": "NP_001097177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097177", "type": "external" } ], "gene_names_uniprotkb": "Pde11; CG10231; CG15159; CG34341; Dmel\\CG34341; Dmel_CG34341; PDE11; pde11", "gene_names_refseq": "CG10231; CG15159; CG34341; Dmel\\CG34341; PDE11; Pde11; pde11", "protein_names_uniprotkb": "Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11; 3.1.4.35; 3.1.4.53; PDE11; cAMP and cGMP phosphodiesterase 11", "protein_names_refseq": "CG34341-PC; Pde11-PC; phosphodiesterase 11, isoform C", "tax_id": 7227, "disease": "stroke (Disease Ontology:DOID:0051061); primary pigmented nodular adrenocortical disease 2 (Disease Ontology:DOID:0070547); pre-eclampsia (Disease Ontology:DOID:10591); primary biliary cholangitis (Disease Ontology:DOID:12236); impotence (Disease Ontology:DOID:1875); IgA glomerulonephritis (Disease Ontology:DOID:2986); vasculogenic impotence (Disease Ontology:DOID:4762); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432)", "pathway": " (dme:Dmel_CG34341); (R-DME-418457); (R-DME-445355); (R-DME-9013422)", "pathway_count": 4, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15673286;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Dual-specificity phosphodiesterase that catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MQW0;Q9VJ78", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0046058 cAMP metabolic process;GO:0007165 signal transduction;GO:0046068 cGMP metabolic process;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VJ79-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VMR8-1", "uniprot_id": [ { "id": "TOTM_DROME", "url": "https://www.uniprot.org/uniprot/Q9VMR8", "type": "external" } ], "mass": 14967.0, "length": 131, "protein_name": "Protein Turandot M", "gene_name": "TotM", "organism": "Fruit fly", "refseq_name": "turandot M, isoform B", "refseq_ac": [ { "id": "NP_001245887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245887", "type": "external" } ], "gene_names_uniprotkb": "TotM; CG14027; Dmel\\CG14027; Dmel_CG14027; TOTM; Tot M; Tot-M; totM; tot", "gene_names_refseq": "CG14027; Dmel\\CG14027; TOTM; Tot M; Tot-M; TotM; totM; tot", "protein_names_uniprotkb": "Protein Turandot M", "protein_names_refseq": "CG14027-PB; TotM-PB; Turandot-M; turandot M, isoform B; turandot", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14027)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;11409894;12537568;12537572;12537573;12537574;16110336;16611243;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "A humoral factor that may play a role in stress tolerance. Requires Mekk1 expression in the fat body to regulate response to septic injury and consequent immune response., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q962D7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0034605 cellular response to heat;GO:0009617 response to bacterium;GO:0009408 response to heat", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VMR8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8I7C3-1", "uniprot_id": [ { "id": "LASP1_DROME", "url": "https://www.uniprot.org/uniprot/Q8I7C3", "type": "external" } ], "mass": 74247.0, "length": 657, "protein_name": "LIM and SH3 domain protein Lasp", "gene_name": "Lasp", "organism": "Fruit fly", "refseq_name": "lasp, isoform A", "refseq_ac": [ { "id": "NP_648912", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648912", "type": "external" } ], "gene_names_uniprotkb": "Lasp; CG3849; Dmel\\CG3849; Dmel_CG3849; anon-73Bd; cDNA B; lasp", "gene_names_refseq": "CG3849; Dmel\\CG3849; Lasp; anon-73Bd; cDNA B; lasp", "protein_names_uniprotkb": "LIM and SH3 domain protein Lasp", "protein_names_refseq": "CG3849-PA; Lasp-PA; lasp, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3849)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17372656;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q59E31;Q9VV91", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005925 focal adhesion;GO:0030018 Z disc;GO:0031672 A band;GO:0070864 sperm individualization complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0045214 sarcomere organization;GO:0007291 sperm individualization;GO:0071689 muscle thin filament assembly;GO:0007279 pole cell formation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8I7C3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3J8-1", "uniprot_id": [ { "id": "WDS_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3J8", "type": "external" } ], "mass": 39041.0, "length": 361, "protein_name": "Protein will die slowly", "gene_name": "wds", "organism": "Fruit fly", "refseq_name": "will die slowly, isoform B", "refseq_ac": [ { "id": "NP_001245503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245503", "type": "external" } ], "gene_names_uniprotkb": "wds; CG17437; Dmel\\CG17437; Dmel_CG17437; EG:BACR25B3.7; WD5; WDR5; WDS; Wds; dWds; l(1)16-94; l(1)3Ad; l(1)G0251; l(1)zw8; zw-8; zw8", "gene_names_refseq": "CG17437; Dmel\\CG17437; EG:BACR25B3.7; WD5; WDR5; WDS; Wds; dWds; l(1)16-94; l(1)3Ad; l(1)G0251; l(1)zw8; wds; zw-8; zw8", "protein_names_uniprotkb": "Protein will die slowly", "protein_names_refseq": "CG17437-PB; lethal(1)3Ad; wds-PB; will die slowly, isoform B; will die slowly", "tax_id": 7227, "disease": "congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (dme:Dmel_CG17437); (R-DME-201722); (R-DME-3214847); (R-DME-8936459); (R-DME-8951664); (R-DME-9772755); (R-DME-9909649); (R-DME-9943962)", "pathway_count": 8, "publication_count": 20, "publication_id_list": "10731132;10731137;12471440;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327268;21694722;21875999;22048023;25310983;25589440;26109356;26109357;30078725", "class_list": "", "function": "Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:25310983). In neurons and together with DNA N6-methyl adenine demethylase Tet, plays a role in the maintenance of transcriptional activation for specific sets of genes (PubMed:30078725)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0044666 MLL3/4 complex;GO:0048188 Set1C/COMPASS complex;GO:0044545 NSL complex;GO:0044665 MLL1/2 complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0007507 heart development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9V3J8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VWA0-1", "uniprot_id": [ { "id": "Q9VWA0_DROME", "url": "https://www.uniprot.org/uniprot/Q9VWA0", "type": "external" } ], "mass": 162266.0, "length": 1465, "protein_name": "DUF4211 domain-containing protein", "gene_name": "CG6918; Dmel\\CG17233", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": [ { "id": "NP_730500", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_730500", "type": "external" } ], "gene_names_uniprotkb": "CG6918; Dmel\\CG17233; CG17233; CG6918; Dmel\\CG17233; Dmel_CG17233", "gene_names_refseq": "CG17233; CG6918; Dmel\\CG17233", "protein_names_uniprotkb": "DUF4211 domain-containing protein", "protein_names_refseq": "CG17233-PC; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17233)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9VW99", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VWA0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27889-1", "uniprot_id": [ { "id": "PP2B2_DROME", "url": "https://www.uniprot.org/uniprot/Q27889", "type": "external" } ], "mass": 63101.0, "length": 570, "protein_name": "Serine/threonine-protein phosphatase 2B catalytic subunit 2", "gene_name": "Pp2B-14D", "organism": "Fruit fly", "refseq_name": "protein phosphatase 2B at 14D, isoform C", "refseq_ac": [ { "id": "NP_001245715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245715", "type": "external" } ], "gene_names_uniprotkb": "Pp2B-14D; CG9842; CaNA; CaN; CanA14D; CanA; CnA; CnnA14D; D33; DmPp2B-14D; Dmel\\CG9842; Dmel_CG9842; PP2B 14D; PP2B-14D; PP2B; Pp12-14D; Pp2B-14DF; Pp2B; Pp2b-14D; PpD33; calneur; canA", "gene_names_refseq": "CG9842; CaNA; CaN; CanA14D; CanA; CnA; CnnA14D; D33; DmPp2B-14D; Dmel\\CG9842; PP2B 14D; PP2B-14D; PP2B; Pp12-14D; Pp2B-14D/CaN; Pp2B-14DF; Pp2B-14D; Pp2B; Pp2b-14D; PpD33; calneur; canA", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2B catalytic subunit 2; 3.1.3.16; Calmodulin-dependent calcineurin A2 subunit", "protein_names_refseq": "CG9842-PC; Pp2B-14D-PC; calcineurin; protein phosphatase 2B at 14D, isoform C; protein phosphatase D33; protein phosphatase from PCR fragment D33", "tax_id": 7227, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); developmental and epileptic encephalopathy 91 (Disease Ontology:DOID:0080472); dilated cardiomyopathy (Disease Ontology:DOID:12930); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); aortic valve stenosis (Disease Ontology:DOID:1712); cholangiocarcinoma (Disease Ontology:DOID:4947); schizophrenia (Disease Ontology:DOID:5419); kidney disease (Disease Ontology:DOID:557)", "pathway": " (dme:Dmel_CG9842); (R-DME-2025928); (R-DME-2871809); (R-DME-4086398); (R-DME-5607763)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;16860743;17569856;17569867;22421435;25589440;26109356;26109357;8313960;8849894", "class_list": "", "function": "Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q26248;Q9VXF2", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0033192 calmodulin-dependent protein phosphatase activity;GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004723 calcium-dependent protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005955 calcineurin complex", "go_biological_process": "GO:0097720 calcineurin-mediated signaling;GO:0030431 sleep;GO:0007143 female meiotic nuclear division;GO:0051321 meiotic cell cycle;GO:0045995 regulation of embryonic development", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q27889-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VXB0-1", "uniprot_id": [ { "id": "NECAP_DROME", "url": "https://www.uniprot.org/uniprot/Q9VXB0", "type": "external" } ], "mass": 26611.0, "length": 246, "protein_name": "NECAP-like protein CG9132", "gene_name": "Dmel\\CG9132", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": [ { "id": "NP_001245720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245720", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG9132; CG32566; CG9132; Dmel_CG9132", "gene_names_refseq": "CG32566; CG9132; Dmel\\CG9132", "protein_names_uniprotkb": "NECAP-like protein CG9132", "protein_names_refseq": "CG9132-PC; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "developmental and epileptic encephalopathy 21 (Disease Ontology:DOID:0080443)", "pathway": " (dme:Dmel_CG9132); (R-DME-432722); (R-DME-8856825); (R-DME-8856828)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "May be involved in endocytosis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IR06", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:0005905 clathrin-coated pit;GO:0016020 membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VXB0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VTX8-1", "uniprot_id": [ { "id": "ODR4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VTX8", "type": "external" } ], "mass": 54587.0, "length": 492, "protein_name": "Protein odr-4 homolog", "gene_name": "Dmel\\CG10616", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": [ { "id": "NP_001287048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287048", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG10616; CG10616; Dmel_CG10616", "gene_names_refseq": "CG10616; Dmel\\CG10616", "protein_names_uniprotkb": "Protein odr-4 homolog", "protein_names_refseq": "CG10616-PC; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10616)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "May play a role in the trafficking of a subset of G protein coupled receptors., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VTX8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VXF1-1", "uniprot_id": [ { "id": "PP2B3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VXF1", "type": "external" } ], "mass": 64285.0, "length": 584, "protein_name": "Serine/threonine-protein phosphatase 2B catalytic subunit 3", "gene_name": "CanA-14F", "organism": "Fruit fly", "refseq_name": "calcineurin A at 14F, isoform C", "refseq_ac": [ { "id": "NP_001245717", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245717", "type": "external" } ], "gene_names_uniprotkb": "CanA-14F; CG9819; CaNA-14F; CaN; CanA14F; CnnA14D(I); CnnA14D; D27; DmCanA-14F; Dmel\\CG9819; Dmel_CG9819; MRE12; PP2B; PpD27; canA-14F", "gene_names_refseq": "CG9819; CaNA-14F; CaN; CanA-14F; CanA14F; CnnA14D(I); CnnA14D; D27; DmCanA-14F; Dmel\\CG9819; MRE12; PP2B; PpD27; canA-14F", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2B catalytic subunit 3; 3.1.3.16; Calmodulin-dependent calcineurin A3 subunit", "protein_names_refseq": "CG9819-PC; CanA-14F-PC; calcineurin A at 14F, isoform C; calcineurin A at 14F; mRNA-like ncRNA in embryogenesis 12; protein phosphatase D27; protein phosphatase from PCR fragment D27", "tax_id": 7227, "disease": "developmental and epileptic encephalopathy 91 (Disease Ontology:DOID:0080472); dilated cardiomyopathy (Disease Ontology:DOID:12930); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); aortic valve stenosis (Disease Ontology:DOID:1712); cholangiocarcinoma (Disease Ontology:DOID:4947); schizophrenia (Disease Ontology:DOID:5419); kidney disease (Disease Ontology:DOID:557)", "pathway": " (dme:Dmel_CG9819); (R-DME-2025928); (R-DME-2871809); (R-DME-4086398); (R-DME-5607763)", "pathway_count": 5, "publication_count": 15, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;16860743;17569856;17569867;18327897;22421435;25589440;26109356;26109357;8849894", "class_list": "", "function": "Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q27573;Q86NL0", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0033192 calmodulin-dependent protein phosphatase activity;GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005955 calcineurin complex", "go_biological_process": "GO:0097720 calcineurin-mediated signaling;GO:0030431 sleep", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VXF1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VX91-1", "uniprot_id": [ { "id": "UBR1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VX91", "type": "external" } ], "mass": 208361.0, "length": 1824, "protein_name": "E3 ubiquitin-protein ligase UBR1", "gene_name": "Ubr1", "organism": "Fruit fly", "refseq_name": "Ubr1 ubiquitin ligase, isoform B", "refseq_ac": [ { "id": "NP_001245723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245723", "type": "external" } ], "gene_names_uniprotkb": "Ubr1; 2; CG9086; Dmel\\CG9086; Dmel_CG9086; UBR1; ubr1", "gene_names_refseq": "CG9086; Dmel\\CG9086; UBR1/2; UBR1; Ubr1; ubr1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase UBR1; 2.3.2.27; N-recognin; RING-type E3 ubiquitin transferase UBR1; Ubiquitin-protein ligase E3-alpha", "protein_names_refseq": "CG9086-PB; Ubr1 ubiquitin ligase, isoform B; Ubr1-PB", "tax_id": 7227, "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); cardiovascular system disease (Disease Ontology:DOID:1287); neurodegenerative disease (Disease Ontology:DOID:1289); Johanson-Blizzard syndrome (Disease Ontology:DOID:14694); atherosclerosis (Disease Ontology:DOID:1936)", "pathway": " (dme:Dmel_CG9086); (R-DME-983168)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation., [UniProtKB]; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5RIU9;Q8SX71", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0016874 ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VX91-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VQK0-1", "uniprot_id": [ { "id": "U518_DROME", "url": "https://www.uniprot.org/uniprot/Q9VQK0", "type": "external" } ], "mass": 113845.0, "length": 1041, "protein_name": "FHIP family protein CG3558", "gene_name": "Dmel\\CG3558", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": [ { "id": "NP_001137777", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137777", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG3558; BEST:LD23852; CG3558; Dmel_CG3558; LD23852; c4.3", "gene_names_refseq": "BEST:LD23852; CG3558; Dmel\\CG3558; LD23852; c4.3", "protein_names_uniprotkb": "FHIP family protein CG3558", "protein_names_refseq": "CG3558-PC; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3558)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B7Z000;Q8IPZ4;Q95SN7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VQK0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VLT5-1", "uniprot_id": [ { "id": "POE_DROME", "url": "https://www.uniprot.org/uniprot/Q9VLT5", "type": "external" } ], "mass": 590702.0, "length": 5322, "protein_name": "Protein purity of essence", "gene_name": "poe", "organism": "Fruit fly", "refseq_name": "purity of essence, isoform B", "refseq_ac": [ { "id": "NP_001260222", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260222", "type": "external" } ], "gene_names_uniprotkb": "poe; 3420; CG14472; Calo; Dmel\\CG14472; Dmel_CG14472; POE_DROME; POE; Poe; UBR4; Ubr4; calo; ms(2)01659; ms(2)27C; ms(2)3420; ms(2)5970; push", "gene_names_refseq": "3420; CG14472; Calo; Dmel\\CG14472; POE/UBR4; POE_DROME; POE; Poe; UBR4; Ubr4; calo; ms(2)01659; ms(2)27C; ms(2)3420; ms(2)5970; poe; push", "protein_names_uniprotkb": "Protein purity of essence; Interaction calmodulin and colossal molecular mass protein; Protein Calossin; Protein pushover", "protein_names_refseq": "CG14472-PB; calossin; male sterile(2)27C; male sterile(2)3420; poe-PB; purity of essence, isoform B; purity of essence; pushover", "tax_id": 7227, "disease": "intellectual disability (Disease Ontology:DOID:1059)", "pathway": " (dme:Dmel_CG14472); (R-DME-6798695); (R-DME-983168)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "10731132;11517334;12537568;12537569;12537572;12537573;12537574;16110336;17372656;17569856;17569867;18327897;25589440;26109356;26109357;27552662;8244010;9813038", "class_list": "", "function": "Has a role in growth of the perineurial glial layer of the larval peripheral nerve (PubMed:27552662). May have a role in male fertility and eye development or function (PubMed:27552662). Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the E2 enzyme Unc6 and the putative E3 ligases Kcmf1 and Ufd4 to mediate the ubiquitination and proteasomal degradation of rl/MAPK (PubMed:27552662)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O96958;Q8MS98;Q9XYD1;Q9XYD2", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0043186 P granule", "go_biological_process": "GO:2000020 positive regulation of male gonad development;GO:0007601 visual perception;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0007291 sperm individualization", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9VLT5-1", "record_type": "protein", "filter_code": "0000000.0000111.000100.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VL63-1", "uniprot_id": [ { "id": "ARGL1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VL63", "type": "external" } ], "mass": 35526.0, "length": 290, "protein_name": "Arginine and glutamate-rich protein 1", "gene_name": "Arglu1", "organism": "Fruit fly", "refseq_name": "arginine and glutamate rich 1, isoform A", "refseq_ac": [ { "id": "NP_609327", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609327", "type": "external" } ], "gene_names_uniprotkb": "Arglu1; CG31712; CG5879; Dmel\\CG31712; Dmel_CG31712; dArglu1", "gene_names_refseq": "Arglu1; CG31712; CG5879; Dmel\\CG31712; dArglu1", "protein_names_uniprotkb": "Arginine and glutamate-rich protein 1; dArglu1", "protein_names_refseq": "Arglu1-PA; CG31712-PA; arginine and glutamate rich 1, isoform A; arginine and glutamate-rich protein 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31712)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;36533631", "class_list": "", "function": "Post-transcriptional regulator of gene expression; modulates splicing and premature cleavage at cryptic polyadenylation sites of its own pre-mRNA through binding and regulation of the U1-snRNP complex., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8T0F4", "ec_number_list": [], "go_molecular_function": "GO:1990446 U1 snRNP binding;GO:0036002 pre-mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0016607 nuclear speck", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VL63-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VKQ3-1", "uniprot_id": [ { "id": "WDR12_DROME", "url": "https://www.uniprot.org/uniprot/Q9VKQ3", "type": "external" } ], "mass": 47222.0, "length": 420, "protein_name": "Ribosome biogenesis protein WDR12 homolog", "gene_name": "Dmel\\CG6724", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": [ { "id": "NP_609452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609452", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG6724; CG6724; Dmel_CG6724", "gene_names_refseq": "CG6724; Dmel\\CG6724", "protein_names_uniprotkb": "Ribosome biogenesis protein WDR12 homolog", "protein_names_refseq": "CG6724-PA; ribosome biogenesis protein WDR12 homolog; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6724); (R-DME-6791226); (R-DME-8951664); (R-DME-983168)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030687 preribosome, large subunit precursor;GO:0070545 PeBoW complex", "go_biological_process": "GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VKQ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZL6-1", "uniprot_id": [ { "id": "LTOR4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZL6", "type": "external" } ], "mass": 13262.0, "length": 120, "protein_name": "Ragulator complex protein LAMTOR4 homolog", "gene_name": "Lamtor4", "organism": "Fruit fly", "refseq_name": "late endosomal/lysosomal adaptor, MAPK and MTOR activator 4, isoform A", "refseq_ac": [ { "id": "NP_647834", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647834", "type": "external" } ], "gene_names_uniprotkb": "Lamtor4; BcDNA:RH34338; CG14977; Dmel\\CG14977; Dmel_CG14977; dC7orf59", "gene_names_refseq": "BcDNA:RH34338; CG14977; Dmel\\CG14977; Lamtor4; dC7orf59", "protein_names_uniprotkb": "Ragulator complex protein LAMTOR4 homolog; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4", "protein_names_refseq": "CG14977-PA; Lamtor4-PA; late endosomal/lysosomal adaptor, MAPK and MTOR activator 4, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14977); (R-DME-1632852); (R-DME-165159); (R-DME-166208); (R-DME-380972); (R-DME-5628897); (R-DME-8943724); (R-DME-9639288)", "pathway_count": 8, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;22980980;25589440;26109356;26109357", "class_list": "", "function": "Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B3DML9;Q8SXW8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005764 lysosome;GO:0071986 Ragulator complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0032008 positive regulation of TOR signaling;GO:0038202 TORC1 signaling;GO:0071230 cellular response to amino acid stimulus;GO:0061462 protein localization to lysosome", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VZL6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VQB7-1", "uniprot_id": [ { "id": "EOGT_DROME", "url": "https://www.uniprot.org/uniprot/Q9VQB7", "type": "external" } ], "mass": 60083.0, "length": 520, "protein_name": "EGF domain-specific O-linked N-acetylglucosamine transferase", "gene_name": "Eogt", "organism": "Fruit fly", "refseq_name": "EGF-domain O-GlcNAc transferase, isoform B", "refseq_ac": [ { "id": "NP_001259934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259934", "type": "external" } ], "gene_names_uniprotkb": "Eogt; CG9867; Dmel\\CG9867; Dmel_CG9867; EOGT; eogt", "gene_names_refseq": "CG9867; Dmel\\CG9867; EOGT; Eogt; eogt", "protein_names_uniprotkb": "EGF domain-specific O-linked N-acetylglucosamine transferase; 2.4.1.255; Extracellular O-linked N-acetylglucosamine transferase", "protein_names_refseq": "CG9867-PB; EGF-domain O-GlcNAc transferase, isoform B; EGF-domain specific O-GlcNAc transferase; Eogt-PB", "tax_id": 7227, "disease": "Adams-Oliver syndrome (Disease Ontology:DOID:0060227)", "pathway": " (dme:Dmel_CG9867)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;22158438;25589440;26109356;26109357", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains. Involved in epithelial cell adhesion/interaction with the extracellular matrix by mediating glycosylation of proteins in the secretory pathway, such as Dumpy (Dp)., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.255", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.255", "type": "external" } ], "go_molecular_function": "GO:0097363 protein O-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0008363 larval chitin-based cuticle development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VQB7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VQX4-1", "uniprot_id": [ { "id": "PNCB_DROME", "url": "https://www.uniprot.org/uniprot/Q9VQX4", "type": "external" } ], "mass": 62165.0, "length": 555, "protein_name": "Nicotinate phosphoribosyltransferase", "gene_name": "Naprt", "organism": "Fruit fly", "refseq_name": "nicotinate phosphoribosyltransferase, isoform F", "refseq_ac": [ { "id": "NP_001097077", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097077", "type": "external" } ], "gene_names_uniprotkb": "Naprt; AAF51037; CG3714; Dmel\\CG3714; Dmel_CG3714", "gene_names_refseq": "AAF51037; CG3714; Dmel\\CG3714; Naprt", "protein_names_uniprotkb": "Nicotinate phosphoribosyltransferase; 6.3.4.21; NAPRTase", "protein_names_refseq": "CG3714-PF; Naprt-PF; nicotinate phosphoribosyltransferase, isoform F", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3714); (R-DME-196807); (R-DME-6798695)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;40245499", "class_list": "", "function": "Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8MRQ7", "ec_number_list": [ { "id": "3.5.2.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.17", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "1.11.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.-", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016740 transferase activity;GO:0004516 nicotinate phosphoribosyltransferase activity;GO:0016757 glycosyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0034355 NAD+ biosynthetic process via the salvage pathway;GO:0009435 NAD+ biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9VQX4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VR35-1", "uniprot_id": [ { "id": "MXT_DROME", "url": "https://www.uniprot.org/uniprot/Q9VR35", "type": "external" } ], "mass": 70148.0, "length": 653, "protein_name": "Eukaryotic translation initiation factor 4E-binding protein Mextli", "gene_name": "mxt", "organism": "Fruit fly", "refseq_name": "mextli, isoform D", "refseq_ac": [ { "id": "NP_001162874", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162874", "type": "external" } ], "gene_names_uniprotkb": "mxt; BcDNA:GH06479; CG2950; Dmel\\CG2950; Dmel_CG2950; Mxt; cg2950", "gene_names_refseq": "BcDNA:GH06479; CG2950; Dmel\\CG2950; Mxt; cg2950; mxt", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4E-binding protein Mextli", "protein_names_refseq": "CG2950-PD; mextli, isoform D; mextli; mxt-PD", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2950)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;23716590;25589440;26109356;26109357;26294658", "class_list": "", "function": "Plays a role in promoting translation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E1JHT5", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008190 eukaryotic initiation factor 4E binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0034518 RNA cap binding complex", "go_biological_process": "GO:0045727 positive regulation of translation;GO:1901190 regulation of formation of translation initiation ternary complex;GO:0036099 female germ-line stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VR35-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3U2-1", "uniprot_id": [ { "id": "NHP2_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3U2", "type": "external" } ], "mass": 17724.0, "length": 160, "protein_name": "H/ACA ribonucleoprotein complex subunit 2", "gene_name": "NHP2", "organism": "Fruit fly", "refseq_name": "NHP2, isoform B", "refseq_ac": [ { "id": "NP_001261849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261849", "type": "external" } ], "gene_names_uniprotkb": "NHP2; CG5258; Dmel\\CG5258; Dmel_CG5258; nhp2", "gene_names_refseq": "CG5258; Dmel\\CG5258; NHP2; nhp2", "protein_names_uniprotkb": "H/ACA ribonucleoprotein complex subunit 2; H/ACA snoRNP protein NHP2; Nucleolar protein family A member 2-like protein", "protein_names_refseq": "CG5258-PB; NHP2, isoform B; NHP2-PB", "tax_id": 7227, "disease": "autosomal recessive dyskeratosis congenita 2 (Disease Ontology:DOID:0070017)", "pathway": " (dme:Dmel_CG5258)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;37343092", "class_list": "", "function": "Component of the box H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (Probable). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (Probable). Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (Probable). Required for ribosome biogenesis (By similarity). H/ACA snoRNP complex-dependent ribosome biogenesis is important in female germline cell differentiation during oogenesis (PubMed:37343092)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q494M4", "ec_number_list": [], "go_molecular_function": "GO:0034513 box H/ACA snoRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0031429 box H/ACA snoRNP complex;GO:0005732 sno(s)RNA-containing ribonucleoprotein complex;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0031118 rRNA pseudouridine synthesis;GO:0031120 snRNA pseudouridine synthesis;GO:0000454 snoRNA guided rRNA pseudouridine synthesis;GO:0048142 germarium-derived cystoblast division;GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9V3U2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VQW7-1", "uniprot_id": [ { "id": "Q9VQW7_DROME", "url": "https://www.uniprot.org/uniprot/Q9VQW7", "type": "external" } ], "mass": 146497.0, "length": 1332, "protein_name": "Echinoid, isoform A; Echinoid, isoform B", "gene_name": "ed", "organism": "Fruit fly", "refseq_name": "echinoid, isoform B", "refseq_ac": [ { "id": "NP_001260013", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260013", "type": "external" } ], "gene_names_uniprotkb": "ed; 1X5; CG12676; CG15424; CG16842; CT13476; CT35484; Dmel\\CG12676; Dmel_CG12676; E(Elp)24D; E(Elp)[24D]; EN2-7; Echinoid; Ed; l(2)k01102", "gene_names_refseq": "1X5; CG12676; CG15424; CG16842; CT13476; CT35484; Dmel\\CG12676; E(Elp)24D; E(Elp)[24D]; EN2-7; Echinoid; Ed; ed; l(2)k01102", "protein_names_uniprotkb": "Echinoid, isoform A; Echinoid, isoform B", "protein_names_refseq": "CG12676-PB; echinoid, isoform B; echinoid; ed-PB; enhancer of NA9 2-7", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12676); (R-DME-373753)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050839 cell adhesion molecule binding;GO:0005154 epidermal growth factor receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005938 cell cortex;GO:0005769 early endosome;GO:0005911 cell-cell junction", "go_biological_process": "GO:0090138 regulation of actin cytoskeleton organization by cell-cell adhesion;GO:0032956 regulation of actin cytoskeleton organization;GO:0098609 cell-cell adhesion;GO:0008360 regulation of cell shape;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VQW7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27597-1", "uniprot_id": [ { "id": "NCPR_DROME", "url": "https://www.uniprot.org/uniprot/Q27597", "type": "external" } ], "mass": 76347.0, "length": 679, "protein_name": "NADPH--cytochrome P450 reductase", "gene_name": "Cpr", "organism": "Fruit fly", "refseq_name": "cytochrome P450 reductase, isoform C", "refseq_ac": [ { "id": "NP_001260128", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260128", "type": "external" } ], "gene_names_uniprotkb": "Cpr; CCR; CG11567; CPR; DMR; DmCPR; Dmel\\CG11567; Dmel_CG11567; NCPR; P450; cpr", "gene_names_refseq": "CCR; CG11567; CPR; Cpr; DMR; DmCPR; Dmel\\CG11567; NCPR; P450; cpr", "protein_names_uniprotkb": "NADPH--cytochrome P450 reductase; 1.6.2.4; CPR; P450R", "protein_names_refseq": "CG11567-PC; Cpr-PC; NADPH--ferrihemoprotein reductase; NADPH-cytochrome P450 oxidoreductase; NADPH-cytochrome P450 reductase; cytochrome P450 reductase, isoform C; cytochrome c reductase (NADPH)", "tax_id": 7227, "disease": "Antley-Bixler syndrome with disordered steroidogenesis (Disease Ontology:DOID:0050462); congenital adrenal hyperplasia (Disease Ontology:DOID:0050811); cytochrome P450 oxidoreductase deficiency (Disease Ontology:DOID:0080925)", "pathway": " (dme:Dmel_CG11567)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;22927409;25589440;26109356;26109357;30917324;9168130", "class_list": "", "function": "This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5., [UniProtKB, HAMAP]; This enzyme is required for electron transfer from NADP to cytochrome p450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome b5 (By similarity). Together with Cyp4g1 involved in production of cuticular hydrocarbons used for waterproofing and chemical communication (PubMed:22927409). May function to clear the olfactory organ (antennae) from accumulating chemicals (PubMed:9168130)., [UniProtKB, HAMAP, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VMF2", "ec_number_list": [ { "id": "1.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.4", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0010181 FMN binding;GO:0050661 NADP binding;GO:0003958 NADPH-hemoprotein reductase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0009725 response to hormone;GO:0006809 nitric oxide biosynthetic process;GO:0006723 cuticle hydrocarbon biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q27597-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VVY3-1", "uniprot_id": [ { "id": "GBS76_DROME", "url": "https://www.uniprot.org/uniprot/Q9VVY3", "type": "external" } ], "mass": 73967.0, "length": 681, "protein_name": "Glycogen-binding subunit 76A", "gene_name": "Gbs-76A", "organism": "Fruit fly", "refseq_name": "glycogen binding subunit 76A, isoform B", "refseq_ac": [ { "id": "NP_001262043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262043", "type": "external" } ], "gene_names_uniprotkb": "Gbs-76A; 149039_at; CG9619; Dmel\\CG9619; Dmel_CG9619; GBS-76A", "gene_names_refseq": "149039_at; CG9619; Dmel\\CG9619; GBS-76A; Gbs-76A", "protein_names_uniprotkb": "Glycogen-binding subunit 76A; CBM21 domain-containing protein CG9619", "protein_names_refseq": "CG9619-PB; Gbs-76A-PB; glycogen binding subunit 76A, isoform B", "tax_id": 7227, "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352); hypoglycemia (Disease Ontology:DOID:9993)", "pathway": " (dme:Dmel_CG9619); (R-DME-3322077)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17372656;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "C3KGL1;Q8T0I8", "ec_number_list": [], "go_molecular_function": "GO:0008157 protein phosphatase 1 binding;GO:2001069 glycogen binding", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex", "go_biological_process": "GO:0045818 negative regulation of glycogen catabolic process;GO:0045725 positive regulation of glycogen biosynthetic process;GO:0005979 regulation of glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VVY3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q94920-1", "uniprot_id": [ { "id": "VDAC_DROME", "url": "https://www.uniprot.org/uniprot/Q94920", "type": "external" } ], "mass": 30550.0, "length": 282, "protein_name": "Voltage-dependent anion-selective channel", "gene_name": "porin", "organism": "Fruit fly", "refseq_name": "porin, isoform C", "refseq_ac": [ { "id": "NP_001033899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033899", "type": "external" } ], "gene_names_uniprotkb": "porin; CG6647; DVDAC; DmPorin1; DmVDAC; Dmel\\CG6647; Dmel_CG6647; POR-1; PORIN; Porin; VDAC1; VDAC; Vdac1; Vdac; anon-WO02059370.56; cg6647; l(2)k05123", "gene_names_refseq": "CG6647; DVDAC; DmPorin1; DmVDAC; Dmel\\CG6647; POR-1; PORIN; Porin; VDAC1; VDAC; Vdac1; Vdac; anon-WO02059370.56; cg6647; l(2)k05123; porin", "protein_names_uniprotkb": "Voltage-dependent anion-selective channel; DmVDAC; Porin", "protein_names_refseq": "CG6647-PC; VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL; mitochondrial porin; porin 1; porin, isoform C; porin-PC; voltage-dependent anion channel", "tax_id": 7227, "disease": "Parkinsonism (Disease Ontology:DOID:0080855); prostate cancer (Disease Ontology:DOID:10283); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); temporal lobe epilepsy (Disease Ontology:DOID:3328); myocardial infarction (Disease Ontology:DOID:5844); retinal degeneration (Disease Ontology:DOID:8466)", "pathway": " (dme:Dmel_CG6647); (R-DME-5205685); (R-DME-5689880); (R-DME-70268)", "pathway_count": 4, "publication_count": 17, "publication_id_list": "10071211;10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;32047033;8797793;9271262;9688565", "class_list": "", "function": "Forms a channel through the mitochondrial outer membrane and also the plasma membrane (By similarity). The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis (By similarity). It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity). The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). In depolarized mitochondria, acts downstream of park to promote mitophagy or prevent apoptosis; polyubiquitination by park promotes mitophagy, while monoubiquitination by park decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29QZ3;Q94997;Q9VKP1", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0015288 porin activity;GO:0008308 voltage-gated monoatomic anion channel activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0046930 pore complex;GO:0016006 Nebenkern", "go_biological_process": "GO:0030382 sperm mitochondrion organization;GO:0006811 monoatomic ion transport;GO:0043066 negative regulation of apoptotic process;GO:0007005 mitochondrion organization;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q94920-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VIK9-1", "uniprot_id": [ { "id": "EFNMT_DROME", "url": "https://www.uniprot.org/uniprot/Q9VIK9", "type": "external" } ], "mass": 76003.0, "length": 673, "protein_name": "eEF1A lysine and N-terminal methyltransferase homolog", "gene_name": "38D.29", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": [ { "id": "NP_610045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610045", "type": "external" } ], "gene_names_uniprotkb": "38D.29; CG2614; Dmel\\CG2614; Dmel_CG2614; METTL13", "gene_names_refseq": "38D.29; CG2614; Dmel\\CG2614; METTL13", "protein_names_uniprotkb": "eEF1A lysine and N-terminal methyltransferase homolog", "protein_names_refseq": "CG2614-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dme:Dmel_CG2614)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Dual methyltransferase. It catalyzes N-terminal methylation of target proteins via its C-terminus. It catalyzes dimethylation on lysine residues of target proteins via its N-terminus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VIK9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3J1-1", "uniprot_id": [ { "id": "VATH_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3J1", "type": "external" } ], "mass": 53734.0, "length": 468, "protein_name": "V-type proton ATPase subunit H", "gene_name": "VhaSFD", "organism": "Fruit fly", "refseq_name": "vacuolar H[+]-ATPase SFD subunit, isoform E", "refseq_ac": [ { "id": "NP_001260510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260510", "type": "external" } ], "gene_names_uniprotkb": "VhaSFD; 144191_at; ATP6V1H; CG17332; Dmel\\CG17332; Dmel_CG17332; V-ATPase; V-type H+-ATPase; V1H; VA; v-ATPase; vhaSFD", "gene_names_refseq": "144191_at; ATP6V1H; CG17332; Dmel\\CG17332; V-ATPase; V-type H+-ATPase; V1H; VA; VhaSFD; v-ATPase; vhaSFD", "protein_names_uniprotkb": "V-type proton ATPase subunit H; V-ATPase subunit H; Vacuolar proton pump subunit H; Vacuolar proton pump subunit SFD", "protein_names_refseq": "CG17332-PE; V-ATPase H-subunit; V-ATPase subunit H; V-ATPase subunit V1H; V1 H subunit; VhaSFD-PE; vacuolar H+-ATPase SFD subunit; vacuolar H[+]-ATPase SFD subunit, isoform E", "tax_id": 7227, "disease": "osteoporosis (Disease Ontology:DOID:11476)", "pathway": " (dme:Dmel_CG17332); (R-DME-1222556); (R-DME-77387); (R-DME-917977); (R-DME-9639288); (R-DME-983712)", "pathway_count": 6, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Subunit H is essential for V-ATPase activity, but not for the assembly of the complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IP12;Q960C9;Q9VJJ2", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0033181 plasma membrane proton-transporting V-type ATPase complex", "go_biological_process": "GO:0007042 lysosomal lumen acidification;GO:0008340 determination of adult lifespan;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9V3J1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KVW5-1", "uniprot_id": [ { "id": "KCNN_DROME", "url": "https://www.uniprot.org/uniprot/Q7KVW5", "type": "external" } ], "mass": 101868.0, "length": 927, "protein_name": "Small conductance calcium-activated potassium channel protein", "gene_name": "SK", "organism": "Fruit fly", "refseq_name": "small conductance calcium-activated potassium channel, isoform N", "refseq_ac": [ { "id": "NP_001096885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096885", "type": "external" } ], "gene_names_uniprotkb": "SK; BcDNA:GM01744; CG10706; CG12733; CG4179; Dmel\\CG10706; Dmel_CG10706; Sk; dSK", "gene_names_refseq": "BcDNA:GM01744; CG10706; CG12733; CG4179; Dmel\\CG10706; SK; Sk; dSK", "protein_names_uniprotkb": "Small conductance calcium-activated potassium channel protein; Protein SK; dSK", "protein_names_refseq": "CG10706-PN; SK-PN; small conductance calcium-activated potassium channel, isoform N", "tax_id": 7227, "disease": "myoclonic dystonia 34 (Disease Ontology:DOID:0060957); paranoid schizophrenia (Disease Ontology:DOID:1229); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); essential tremor (Disease Ontology:DOID:4990); schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dme:Dmel_CG10706); (R-DME-1296052)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17018572;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4V3Z5;A8WHR7;Q058W0;Q7KVW6;Q8IRR8;Q8IS28;Q8IS29;Q8MRM1;Q8MRR6;Q9W4C6;Q9W4C7", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0016286 small conductance calcium-activated potassium channel activity;GO:0009881 photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043025 neuronal cell body;GO:0043005 neuron projection", "go_biological_process": "GO:0006813 potassium ion transport;GO:0071805 potassium ion transmembrane transport;GO:0016057 regulation of membrane potential in photoreceptor cell", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q7KVW5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W0E3-1", "uniprot_id": [ { "id": "IML1_DROME", "url": "https://www.uniprot.org/uniprot/Q9W0E3", "type": "external" } ], "mass": 176732.0, "length": 1544, "protein_name": "GATOR complex protein Iml1", "gene_name": "Iml1", "organism": "Fruit fly", "refseq_name": "increased minichromosome loss 1, isoform B", "refseq_ac": [ { "id": "NP_647618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647618", "type": "external" } ], "gene_names_uniprotkb": "Iml1; CG12090; DEPDC5; Dmel\\CG12090; Dmel_CG12090; GATOR1; IMl1; SEA1; iml1; iml", "gene_names_refseq": "CG12090; Dmel\\CG12090; GATOR1; IMl1; Iml1; SEA1; iml1; iml", "protein_names_uniprotkb": "GATOR complex protein Iml1; Increased minichromosome loss 1", "protein_names_refseq": "CG12090-PB; Iml1-PB; increased minichromosome loss 1, isoform B", "tax_id": 7227, "disease": "familial focal epilepsy with variable foci 1 (Disease Ontology:DOID:0081421); developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); cancer (Disease Ontology:DOID:162); epilepsy (Disease Ontology:DOID:1826); focal epilepsy (Disease Ontology:DOID:2234)", "pathway": " (dme:Dmel_CG12090)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;23723238;25512509;25589440;26109356;26109357;27166823;27672113", "class_list": "", "function": "An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:25512509, PubMed:27672113). The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:23723238, PubMed:25512509, PubMed:27672113). The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid or complete starvation by inhibiting TORC1-dependent cell growth and promoting catabolic metabolism and autophagy (PubMed:23723238, PubMed:25512509, PubMed:27672113). GATOR1 and GATOR2 act at different stages of oogenesis to regulate TORC1 in order to control meiotic entry and promote oocyte growth and development (PubMed:25512509, PubMed:27672113). After exactly four mitotic cyst divisions, the GATOR1 complex members (Iml1, Nprl2 and Nprl3) down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition (PubMed:25512509, PubMed:27672113). At later stages of oogenesis, the mio and Nup44A components of the GATOR2 complex inhibit GATOR1 and thus activate TORC1 to promote meiotic progression, and drive oocyte growth and development (PubMed:25512509, PubMed:27672113)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E8NH72;Q8IRG9;Q8SY36", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:1990130 GATOR1 complex;GO:0035859 Seh1-associated complex", "go_biological_process": "GO:0010508 positive regulation of autophagy;GO:0032007 negative regulation of TOR signaling;GO:0045792 negative regulation of cell size;GO:0034198 cellular response to amino acid starvation;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9W0E3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VRX6-1", "uniprot_id": [ { "id": "INX4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VRX6", "type": "external" } ], "mass": 42784.0, "length": 367, "protein_name": "Innexin inx4", "gene_name": "zpg", "organism": "Fruit fly", "refseq_name": "zero population growth, isoform B", "refseq_ac": [ { "id": "NP_001261478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261478", "type": "external" } ], "gene_names_uniprotkb": "zpg; CG10125; Dm-inx4; Dmel\\CG10125; Dmel_CG10125; FBpp0076692; Inx4; Zpg; innexin4; inx-4; inx4; inx", "gene_names_refseq": "CG10125; Dm-inx4; Dmel\\CG10125; FBpp0076692; Inx4; Zpg; innexin4; inx-4; inx4; zpg", "protein_names_uniprotkb": "Innexin inx4; Innexin-4; Protein zero population growth", "protein_names_refseq": "CG10125-PB; Innexin-4; innexin 4; zero population growth, isoform B; zpg-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10125)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;11960713;11973283;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Structural component of the gap junctions in germline cells. Required for differentiation and survival of germline cysts in females and of spermatogonia in males; gap junctional communication between spermatogonia and somatic cyst cells may be required for normal differentiation and survival of spermatogonia., [UniProtKB, PubMed, PubMed]; Structural component of the gap junctions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0055077 gap junction hemi-channel activity;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005921 gap junction", "go_biological_process": "GO:0007283 spermatogenesis;GO:0034220 monoatomic ion transmembrane transport;GO:0007281 germ cell development;GO:0007602 phototransduction;GO:0036098 male germ-line stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VRX6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IQ13-1", "uniprot_id": [ { "id": "EIF1A_DROME", "url": "https://www.uniprot.org/uniprot/Q8IQ13", "type": "external" } ], "mass": 18538.0, "length": 159, "protein_name": "Probable RNA-binding protein EIF1AD", "gene_name": "Dmel\\CG31957", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001260011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260011", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG31957; CG31957; Dmel_CG31957", "gene_names_refseq": "CG31957; Dmel\\CG31957", "protein_names_uniprotkb": "Probable RNA-binding protein EIF1AD; Eukaryotic translation initiation factor 1A domain-containing protein", "protein_names_refseq": "CG31957-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31957)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q8IQ13-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VY93-1", "uniprot_id": [ { "id": "MTNB_DROME", "url": "https://www.uniprot.org/uniprot/Q9VY93", "type": "external" } ], "mass": 26011.0, "length": 227, "protein_name": "Probable methylthioribulose-1-phosphate dehydratase", "gene_name": "1", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001259530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259530", "type": "external" } ], "gene_names_uniprotkb": "1; CG11134; Dmel\\CG11134; Dmel_CG11134", "gene_names_refseq": "1; CG11134; Dmel\\CG11134", "protein_names_uniprotkb": "Probable methylthioribulose-1-phosphate dehydratase; 4.2.1.109; MTRu-1-P dehydratase", "protein_names_refseq": "CG11134-PB; transcript 1; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11134); (R-DME-111458); (R-DME-9627069)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P)., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.22.61", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.61", "type": "external" }, { "id": "4.2.1.109", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.109", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046570 methylthioribulose 1-phosphate dehydratase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0019509 L-methionine salvage from methylthioadenosine", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VY93-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VTE9-1", "uniprot_id": [ { "id": "ULA1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VTE9", "type": "external" } ], "mass": 58717.0, "length": 524, "protein_name": "Nedd8-activating enzyme E1 regulatory subunit", "gene_name": "APP-BP1", "organism": "Fruit fly", "refseq_name": "beta-Amyloid precursor protein binding protein 1, isoform B", "refseq_ac": [ { "id": "NP_001261699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261699", "type": "external" } ], "gene_names_uniprotkb": "APP-BP1; APPBP1; APP; CG7828; Dmel\\CG7828; Dmel_CG7828; anon-WO0140519.225; dAPP-BP1; dAPPBP1", "gene_names_refseq": "APP-BP1; APPBP1; APP; CG7828; Dmel\\CG7828; anon-WO0140519.225; dAPP-BP1; dAPPBP1", "protein_names_uniprotkb": "Nedd8-activating enzyme E1 regulatory subunit; Beta-amyloid precursor binding protein 1; dAPP-BP1", "protein_names_refseq": "APP-BP1-PB; CG7828-PB; beta-Amyloid precursor protein binding protein 1, isoform B", "tax_id": 7227, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); middle cerebral artery infarction (Disease Ontology:DOID:3525)", "pathway": " (dme:Dmel_CG7828)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;16628230;17569856;17569867;21931660;25589440;26109356;26109357", "class_list": "", "function": "Regulatory subunit of the dimeric Uba3-APP-BP1 E1 enzyme. E1 activates Nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a Nedd8-Uba3 thioester and free AMP. E1 finally transfers Nedd8 to the catalytic cysteine of UbcE2M. Required for Cul1 and Cul3 neddylation. Appl and APP-BP1 interact antagonistically during development., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B6IDX9;Q8IHE1", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0001540 amyloid-beta binding;GO:0019781 NEDD8 activating enzyme activity", "go_cellular_component": "GO:0120500 NAE1-UBA3 complex", "go_biological_process": "GO:0045116 protein neddylation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VTE9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VM65-1", "uniprot_id": [ { "id": "FGOP2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VM65", "type": "external" } ], "mass": 35150.0, "length": 315, "protein_name": "FGFR1 oncogene partner 2 homolog", "gene_name": "Fgop2", "organism": "Fruit fly", "refseq_name": "fibroblast growth factor receptor 1 oncogene partner 2, isoform B", "refseq_ac": [ { "id": "NP_001260171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260171", "type": "external" } ], "gene_names_uniprotkb": "Fgop2; CG10158; Dmel\\CG10158; Dmel_CG10158; FGFR1OP2; FGOP2", "gene_names_refseq": "CG10158; Dmel\\CG10158; FGFR1OP2; FGOP2; Fgop2", "protein_names_uniprotkb": "FGFR1 oncogene partner 2 homolog", "protein_names_refseq": "CG10158-PB; Fgop2-PB; fibroblast growth factor receptor 1 oncogene partner 2 ortholog; fibroblast growth factor receptor 1 oncogene partner 2, isoform B; fibroblast growth factor receptor 1 oncogene partner 2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10158)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0090443 FAR/SIN/STRIPAK complex", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0035330 regulation of hippo signaling;GO:0035331 negative regulation of hippo signaling", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VM65-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VTV1-1", "uniprot_id": [ { "id": "THOC6_DROME", "url": "https://www.uniprot.org/uniprot/Q9VTV1", "type": "external" } ], "mass": 39221.0, "length": 350, "protein_name": "THO complex subunit 6", "gene_name": "thoc6", "organism": "Fruit fly", "refseq_name": "thoc6, isoform B", "refseq_ac": [ { "id": "NP_001261750", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261750", "type": "external" } ], "gene_names_uniprotkb": "thoc6; CG5632; Dmel\\CG5632; Dmel_CG5632; THOC6; Thoc6", "gene_names_refseq": "CG5632; Dmel\\CG5632; THOC6; Thoc6; thoc6", "protein_names_uniprotkb": "THO complex subunit 6", "protein_names_refseq": "CG5632-PB; thoc6, isoform B; thoc6-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5632); (R-DME-159236)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15133499;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q705B9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000347 THO complex;GO:0000346 transcription export complex", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0034587 piRNA processing;GO:0031990 mRNA export from nucleus in response to heat stress", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VTV1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VWV9-1", "uniprot_id": [ { "id": "PORCN_DROME", "url": "https://www.uniprot.org/uniprot/Q9VWV9", "type": "external" } ], "mass": 59195.0, "length": 525, "protein_name": "Protein-serine O-palmitoleoyltransferase porcupine", "gene_name": "por", "organism": "Fruit fly", "refseq_name": "porcupine, isoform B", "refseq_ac": [ { "id": "NP_001259679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259679", "type": "external" } ], "gene_names_uniprotkb": "por; 15175; CG6205; Dmel\\CG6205; Dmel_CG6205; Porc; Por; dmPorc; l(1)17Ac; poc; porc", "gene_names_refseq": "15175; CG6205; Dmel\\CG6205; Porc; Por; dmPorc; l(1)17Ac; poc; porc; por", "protein_names_uniprotkb": "Protein-serine O-palmitoleoyltransferase porcupine; 2.3.1.250", "protein_names_refseq": "CG6205-PB; por-PB; porcupine, isoform B; porcupine", "tax_id": 7227, "disease": "focal dermal hypoplasia (Disease Ontology:DOID:2120)", "pathway": " (dme:Dmel_CG6205)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;11821428;12537568;12537569;12537572;12537573;12537574;15166250;16110336;17569856;17569867;22108505;25589440;26109356;26109357;8985181", "class_list": "", "function": "Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt proteins. Serine palmitoleoylation of Wnt proteins is required for efficient binding to frizzled receptors (By similarity). Also facilitates the glycosylation of Wnt family members, including wg and Wnt5. The cotranslational disulfide bond formation of wg competes with the N-glycosylation. Porc stimulates the post-translational N-glycosylation by anchoring wg at the ER membrane, probably through acylation (PubMed:11821428, PubMed:15166250, PubMed:22108505, PubMed:8985181)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 1, "mined_n_glycosites": 0, "mined_o_glycosites": 1, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q94549", "ec_number_list": [ { "id": "2.3.1.250", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.250", "type": "external" } ], "go_molecular_function": "GO:0017147 Wnt-protein binding;GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups;GO:1990698 palmitoleoyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016486 peptide hormone processing;GO:0016055 Wnt signaling pathway;GO:0030111 regulation of Wnt signaling pathway;GO:0008104 intracellular protein localization;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 1.7, "record_id": "Q9VWV9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000010000000.010.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VUI3-1", "uniprot_id": [ { "id": "EMAL_DROME", "url": "https://www.uniprot.org/uniprot/Q9VUI3", "type": "external" } ], "mass": 119255.0, "length": 1076, "protein_name": "Echinoderm microtubule-associated protein-like CG42247", "gene_name": "DCX-EMAP", "organism": "Fruit fly", "refseq_name": "Doublecortin-domain-containing echinoderm-microtubule-associated protein, isoform C", "refseq_ac": [ { "id": "NP_648728", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648728", "type": "external" } ], "gene_names_uniprotkb": "DCX-EMAP; CG13466; CG13467; CG42247; Dmel\\CG42247; Dmel_CG42247; anon-71Aa; dmEMAP", "gene_names_refseq": "CG13466; CG13467; CG42247; DCX-EMAP; Dmel\\CG42247; anon-71Aa; dmEMAP", "protein_names_uniprotkb": "Echinoderm microtubule-associated protein-like CG42247", "protein_names_refseq": "CG42247-PC; DCX-EMAP-PC; Doublecortin-domain-containing echinoderm-microtubule-associated protein ortholog; Doublecortin-domain-containing echinoderm-microtubule-associated protein, isoform C; doublecortin-domain-containing echinoderm-microtubule-associated protein", "tax_id": 7227, "disease": "subcortical band heterotopia (Disease Ontology:DOID:0111169); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); epilepsy (Disease Ontology:DOID:1826); congenital nervous system abnormality (Disease Ontology:DOID:2490); skin melanoma (Disease Ontology:DOID:8923)", "pathway": " (dme:Dmel_CG42247); (R-DME-9648025)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10603347;10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4IJ53;Q8IGY9;Q9NII4;Q9VUI2", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0140778 microtubule stabilizing activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005874 microtubule;GO:0071683 sensory dendrite;GO:0005856 cytoskeleton", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:0035556 intracellular signal transduction;GO:0007605 sensory perception of sound;GO:0071260 cellular response to mechanical stimulus;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VUI3-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9U6L4-1", "uniprot_id": [ { "id": "TTY1_DROME", "url": "https://www.uniprot.org/uniprot/Q9U6L4", "type": "external" } ], "mass": 105828.0, "length": 970, "protein_name": "Protein tweety", "gene_name": "tty", "organism": "Fruit fly", "refseq_name": "tweety, isoform A", "refseq_ac": [ { "id": "NP_542443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_542443", "type": "external" } ], "gene_names_uniprotkb": "tty; CG1693; Dmel\\CG1693; Dmel_CG1693; TTYH1; twe", "gene_names_refseq": "CG1693; Dmel\\CG1693; TTYH1; tty; twe", "protein_names_uniprotkb": "Protein tweety; Dttyh1", "protein_names_refseq": "CG1693-PA; tty-PA; tweety, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1693); (R-DME-2672351)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;10731138;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;8552658;9520435", "class_list": "", "function": "Non-essential protein that probably acts as a chloride channel., [UniProtKB]; Probable chloride channel., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "O61343;Q8IQ48;Q9VRG9", "ec_number_list": [], "go_molecular_function": "GO:0072320 volume-sensitive chloride channel activity;GO:0005229 intracellularly calcium-gated chloride channel activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0034707 chloride channel complex;GO:0036020 endolysosome membrane", "go_biological_process": "GO:1901098 positive regulation of autophagosome maturation;GO:0006821 chloride transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9U6L4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VTY4-1", "uniprot_id": [ { "id": "KXDL1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VTY4", "type": "external" } ], "mass": 23411.0, "length": 212, "protein_name": "KxDL motif-containing protein CG10681", "gene_name": "Dmel\\CG10681", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001261766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261766", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG10681; CG10681; Dmel_CG10681", "gene_names_refseq": "CG10681; Dmel\\CG10681", "protein_names_uniprotkb": "KxDL motif-containing protein CG10681", "protein_names_refseq": "CG10681-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)", "pathway": " (dme:Dmel_CG10681)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098574 cytoplasmic side of lysosomal membrane;GO:0099078 BORC complex", "go_biological_process": "GO:0032418 lysosome localization;GO:0072384 organelle transport along microtubule", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VTY4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VUU5-1", "uniprot_id": [ { "id": "KLHDB_DROME", "url": "https://www.uniprot.org/uniprot/Q9VUU5", "type": "external" } ], "mass": 68923.0, "length": 623, "protein_name": "Kelch-like protein diablo", "gene_name": "dbo", "organism": "Fruit fly", "refseq_name": "diablo, isoform A", "refseq_ac": [ { "id": "NP_524989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524989", "type": "external" } ], "gene_names_uniprotkb": "dbo; CG6224; DIABLO; Dbo; Dm.DBO; Dmel\\CG6224; Dmel_CG6224; Smac; henji", "gene_names_refseq": "CG6224; DIABLO; Dbo; Dm.DBO; Dmel\\CG6224; Smac; dbo; henji", "protein_names_uniprotkb": "Kelch-like protein diablo", "protein_names_refseq": "CG6224-PA; DIABLO; dDiablo; dbo-PA; diablo, isoform A; henji", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6224); (R-DME-8951664); (R-DME-983168)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;16408305;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May have a role in synapse differentiation and growth., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9NGX7", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0045886 negative regulation of synaptic assembly at neuromuscular junction", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VUU5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VUV4-1", "uniprot_id": [ { "id": "Q9VUV4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VUV4", "type": "external" } ], "mass": 95257.0, "length": 861, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "sff", "organism": "Fruit fly", "refseq_name": "sugar-free frosting, isoform A", "refseq_ac": [ { "id": "NP_648814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648814", "type": "external" } ], "gene_names_uniprotkb": "sff; BRSK1; CG6114; Dmel\\CG6114; Dmel_CG6114", "gene_names_refseq": "BRSK1; CG6114; Dmel\\CG6114; sff", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "CG6114-PA; SNF1-related; sff-PA; sugar-free frosting, isoform A", "tax_id": 7227, "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (dme:Dmel_CG6114)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity;GO:0050321 tau-protein kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007399 nervous system development;GO:0007528 neuromuscular junction development;GO:0006487 protein N-linked glycosylation;GO:0007409 axonogenesis;GO:0000086 G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VUV4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VK45-1", "uniprot_id": [ { "id": "TOR_DROME", "url": "https://www.uniprot.org/uniprot/Q9VK45", "type": "external" } ], "mass": 281033.0, "length": 2470, "protein_name": "Serine/threonine-protein kinase mTor", "gene_name": "mTor", "organism": "Fruit fly", "refseq_name": "mechanistic target of rapamycin, isoform A", "refseq_ac": [ { "id": "NP_524891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524891", "type": "external" } ], "gene_names_uniprotkb": "mTor; 5092; CG5092; CT16317; CT24745; CT24817; DmTOR; Dmel\\CG5092; Dmel_CG5092; MTOR; Mtor; TOR-C1; TORC1; TOR; Tor-C1; Torc1; Tor; dTORC1; dTOR; dTor; dtor; l(2)k17004; mTOR; mtor; tor", "gene_names_refseq": "5092; CG5092; CT16317; CT24745; CT24817; DmTOR; Dmel\\CG5092; FRAP/TOR; MTOR; Mtor; TOR-C1; TORC1; TOR; Tor-C1; Torc1; Tor; dTORC1; dTOR; dTor; dtor; l(2)k17004; mTOR; mTor; mtor; tor", "protein_names_uniprotkb": "Serine/threonine-protein kinase mTor; 2.7.11.1; Target of rapamycin; mechanistic Target of rapamycin", "protein_names_refseq": "CG5092-PA; Target-of-rapamycin; mTOR; mTor-PA; mechanistic target of rapamycin, isoform A; target of rapamycin complex 1; target of rapamycin kinase", "tax_id": 7227, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); polycystic kidney disease (Disease Ontology:DOID:0080322); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); prostate cancer (Disease Ontology:DOID:10283); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); crescentic glomerulonephritis (Disease Ontology:DOID:13139); interstitial cystitis (Disease Ontology:DOID:13949); cancer (Disease Ontology:DOID:162); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); colon cancer (Disease Ontology:DOID:219); transient cerebral ischemia (Disease Ontology:DOID:224); idiopathic interstitial pneumonia (Disease Ontology:DOID:2797); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); temporal lobe epilepsy (Disease Ontology:DOID:3328); chondrosarcoma (Disease Ontology:DOID:3371); middle cerebral artery infarction (Disease Ontology:DOID:3525); renal cell carcinoma (Disease Ontology:DOID:4450); ureteral obstruction (Disease Ontology:DOID:5199); lung small cell carcinoma (Disease Ontology:DOID:5409); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); muscular atrophy (Disease Ontology:DOID:767); end stage renal disease (Disease Ontology:DOID:783); kidney angiomyolipoma (Disease Ontology:DOID:8411); vascular dementia (Disease Ontology:DOID:8725); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG5092); (R-DME-1257604); (R-DME-1632852); (R-DME-165159); (R-DME-166208); (R-DME-3371571); (R-DME-380972); (R-DME-389357); (R-DME-5218920); (R-DME-5628897); (R-DME-8943724); (R-DME-9639288); (R-DME-9856530)", "pathway_count": 13, "publication_count": 25, "publication_id_list": "10731132;11069885;11069888;12537568;12537572;12537573;12537574;12559758;14505573;15454083;16110336;16219781;16469695;17569856;17569867;18086911;18604198;18992839;19211682;19225150;25356674;25589440;25920570;26109356;26109357", "class_list": "", "function": "Promotes cell and tissue growth, maintains tissue homeostasis and controls responses to environmental stress and aging (PubMed:11069885, PubMed:11069888, PubMed:19211682, PubMed:19225150). Regulates growth during animal development by coupling growth factor signaling to nutrient availability (PubMed:11069888). Central regulators of autophagy (PubMed:18604198, PubMed:19225150). May be involved in atg1 phosphorylation (PubMed:19225150). May also be involved, directly or indirectly, in the control of neuronal function (PubMed:15454083). Phosphorylates S6K/p70S6K, in vitro (PubMed:11069888). May regulate the activity of S6K (PubMed:11069885). Overexpression inhibits growth and reduces cell size (PubMed:14505573). Affects the timing of neuronal cell differentiation (PubMed:15454083). Hyperactivation of the signaling leads to accelerated differentiation, whereas inhibition of the signaling retards differentiation (PubMed:15454083). Thus, in addition to controlling growth of the cell in which it resides, it can also influence growth of distant cells and organs during development via a humoral mechanism (PubMed:14505573). As part of the TORC1 complex regulates energy homeostasis and promotes certain aspects of larval growth by negatively regulating REPTOR (PubMed:25920570). REPTOR functions downstream of TORC1 to regulate the expression of stress response genes in response to TORC1 inhibition resulting from nutrient deprivation (PubMed:25920570). When TORC1 activity is high it phosphorylates REPTOR which inhibits its recruitment into the nucleus and antagonizes their function (PubMed:25920570). This function is essential under normal feeding conditions to promote TORC1-dependent growth during larval development and, in adults and larvae to prevent the REPTOR-dependent expression of nutrient stress response genes (PubMed:25920570). In short, during development, it primarily controls growth, whereas in the adult, where there is relatively little growth, it controls aging and other aspects of nutrient-related physiology (PubMed:11069885, PubMed:11069888, PubMed:19211682, PubMed:19225150). Rag GTPases act as activators of TORC1 in response to amino acid signals (PubMed:18604198). Regulates ribosome biogenesis through regulation of RNA polymerase I-specific transcription initiation factor Tif-IA levels (PubMed:18086911, PubMed:25356674). Required in muscle to drive systemic growth in a Tif-IA-dependent manner (PubMed:25356674)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 35, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0044877 protein-containing complex binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031931 TORC1 complex;GO:0031932 TORC2 complex", "go_biological_process": "GO:0031670 cellular response to nutrient;GO:0043066 negative regulation of apoptotic process;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0016236 macroautophagy;GO:0035264 multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 2.6, "record_id": "Q9VK45-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VVA0-1", "uniprot_id": [ { "id": "Y9705_DROME", "url": "https://www.uniprot.org/uniprot/Q9VVA0", "type": "external" } ], "mass": 15779.0, "length": 143, "protein_name": "Cold shock domain-containing protein CG9705", "gene_name": "Dmel\\CG9705", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": [ { "id": "NP_001261972", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261972", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG9705; CG9705; Dmel_CG9705", "gene_names_refseq": "CG9705; Dmel\\CG9705", "protein_names_uniprotkb": "Cold shock domain-containing protein CG9705", "protein_names_refseq": "CG9705-PC; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9705)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17372656;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0043488 regulation of mRNA stability;GO:0048813 dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VVA0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VUY0-1", "uniprot_id": [ { "id": "MOX11_DROME", "url": "https://www.uniprot.org/uniprot/Q9VUY0", "type": "external" } ], "mass": 79456.0, "length": 698, "protein_name": "MOXD1 homolog 1", "gene_name": "Dmel\\CG5235", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001261921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261921", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG5235; CG5235; Dmel_CG5235", "gene_names_refseq": "CG5235; Dmel\\CG5235", "protein_names_uniprotkb": "MOXD1 homolog 1; 1.14.17.-", "protein_names_refseq": "CG5235-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5235)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;11900973;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q8SYE9", "ec_number_list": [], "go_molecular_function": "GO:0005507 copper ion binding;GO:0004500 dopamine beta-monooxygenase activity;GO:0004836 tyramine-beta hydroxylase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030667 secretory granule membrane", "go_biological_process": "GO:0042420 dopamine catabolic process;GO:0006589 octopamine biosynthetic process;GO:0042421 norepinephrine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VUY0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VW17-1", "uniprot_id": [ { "id": "Q9VW17_DROME", "url": "https://www.uniprot.org/uniprot/Q9VW17", "type": "external" } ], "mass": 19284.0, "length": 182, "protein_name": "Uncharacterized protein", "gene_name": "BcDNA:RH51268", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": [ { "id": "NP_730432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_730432", "type": "external" } ], "gene_names_uniprotkb": "BcDNA:RH51268; CG9368; Dmel\\CG9368; Dmel_CG9368", "gene_names_refseq": "BcDNA:RH51268; CG9368; Dmel\\CG9368", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG9368-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9368)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VW17-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VVR0-1", "uniprot_id": [ { "id": "Y3380_DROME", "url": "https://www.uniprot.org/uniprot/Q9VVR0", "type": "external" } ], "mass": 19725.0, "length": 169, "protein_name": "Uncharacterized protein CG13380", "gene_name": "Dmel\\CG13380", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001034030", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034030", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG13380; CG13380; Dmel_CG13380", "gene_names_refseq": "CG13380; Dmel\\CG13380", "protein_names_uniprotkb": "Uncharacterized protein CG13380", "protein_names_refseq": "CG13380-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13380)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17372656;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VVR0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9NBK5-1", "uniprot_id": [ { "id": "TRC_DROME", "url": "https://www.uniprot.org/uniprot/Q9NBK5", "type": "external" } ], "mass": 53333.0, "length": 463, "protein_name": "Serine/threonine-protein kinase tricornered", "gene_name": "trc", "organism": "Fruit fly", "refseq_name": "tricornered, isoform B", "refseq_ac": [ { "id": "NP_001262071", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262071", "type": "external" } ], "gene_names_uniprotkb": "trc; 17; CG8637; Dmel\\CG8637; Dmel_CG8637; NDR; Ndr; RE-D; Trc; dmTRC; l(3)76BDa; l(3)S066917", "gene_names_refseq": "0669/17; CG8637; Dmel\\CG8637; NDR; Ndr; RE-D; Trc; dmTRC; l(3)76BDa; l(3)S066917; trc", "protein_names_uniprotkb": "Serine/threonine-protein kinase tricornered; 2.7.11.1; NDR protein kinase; Serine/threonine-protein kinase 38-like; Serine/threonine-protein kinase tricorner", "protein_names_refseq": "CG8637-PB; nuclear Dbf2-related protein kinase; trc-PB; tricornered, isoform B; tricornered; tricorner", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8637); (R-DME-9013418); (R-DME-9013422)", "pathway_count": 3, "publication_count": 18, "publication_id_list": "10731132;11102376;12537568;12537569;12537572;12537573;12537574;15479641;15975907;16110336;17569856;17569867;20406475;25589440;26109356;26109357;32022690;7761441", "class_list": "", "function": "Serine/threonine-protein kinase involved in controlling cell structure and proliferation of a variety of polarized outgrowths including epidermal hairs, bristles, arista laterals, and dendrites (PubMed:11102376, PubMed:15479641, PubMed:32022690). Together with fry, maintains the integrity of epidermal hairs and is an essential component of the signaling pathway regulating dendritic branching of sensory neurons (PubMed:15479641). Reduces neurite outgrowth by phosphorylating pav, thereby inhibiting its function in microtubule-microtubule sliding (PubMed:32022690)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24464;Q9NGW6;Q9VW46", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005938 cell cortex;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0035556 intracellular signal transduction;GO:0048814 regulation of dendrite morphogenesis;GO:0048813 dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9NBK5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9U4L6-1", "uniprot_id": [ { "id": "TO401_DROME", "url": "https://www.uniprot.org/uniprot/Q9U4L6", "type": "external" } ], "mass": 36336.0, "length": 344, "protein_name": "Mitochondrial import receptor subunit TOM40 homolog 1", "gene_name": "Tom40", "organism": "Fruit fly", "refseq_name": "translocase of outer membrane 40, isoform C", "refseq_ac": [ { "id": "NP_001259313", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259313", "type": "external" } ], "gene_names_uniprotkb": "Tom40; CG12157; Dmel\\CG12157; Dmel_CG12157; dtom40; l(1)G0216; mit; ms(1)15; ms15; tom40", "gene_names_refseq": "CG12157; Dmel\\CG12157; Tom40; dtom40; l(1)G0216; mit; ms(1)15; ms15; tom40", "protein_names_uniprotkb": "Mitochondrial import receptor subunit TOM40 homolog 1; Male sterile protein 15; Translocase of outer membrane 40 kDa subunit homolog 1; dtom40", "protein_names_refseq": "CG12157-PC; Tom40-PC; membrane import protein; translocase of outer membrane 40, isoform C", "tax_id": 7227, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); cerebral infarction (Disease Ontology:DOID:3526)", "pathway": " (dme:Dmel_CG12157)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;15304338;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Channel-forming protein essential for import of protein precursors into mitochondria., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V439;Q9W3P9", "ec_number_list": [], "go_molecular_function": "GO:0015288 porin activity;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0046930 pore complex;GO:0005742 mitochondrial outer membrane translocase complex", "go_biological_process": "GO:0045040 protein insertion into mitochondrial outer membrane;GO:0006811 monoatomic ion transport;GO:0071456 cellular response to hypoxia;GO:0006626 protein targeting to mitochondrion;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9U4L6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3I5-1", "uniprot_id": [ { "id": "JIL1_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3I5", "type": "external" } ], "mass": 137045.0, "length": 1207, "protein_name": "Chromosomal serine/threonine-protein kinase JIL-1", "gene_name": "JIL-1", "organism": "Fruit fly", "refseq_name": "JIL-1 kinase, isoform C", "refseq_ac": [ { "id": "NP_001261697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261697", "type": "external" } ], "gene_names_uniprotkb": "JIL-1; 2Ab17; CG6297; Dmel\\CG6297; Dmel_CG6297; IL-1; JIL1; JIL; JiL-1; Jil-1; Jil1; MSK1; MSK; Su(var)3-103; Su(var)3-1; Su-var(3)103; Su-var(3)1; anon-WO0118547.379; jil-1; mAb2A", "gene_names_refseq": "2Ab17; CG6297; Dmel\\CG6297; IL-1; JIL-1; JIL1; JIL; JiL-1; Jil-1; Jil1; MSK1; MSK; Su(var)3-103; Su(var)3-1; Su-var(3)103; Su-var(3)1; anon-WO0118547.379; jil-1; mAb2A", "protein_names_uniprotkb": "Chromosomal serine/threonine-protein kinase JIL-1; 2.7.11.1", "protein_names_refseq": "CG6297-PC; JIL-1 histone H3S10 kinase; JIL-1 histone kinase; JIL-1 kinase, isoform C; JIL-1-PC; suppressor of variegation 3-1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6297); (R-DME-198753); (R-DME-199920); (R-DME-375165); (R-DME-5621575)", "pathway_count": 5, "publication_count": 21, "publication_id_list": "10445035;10731132;10831604;11371341;12537568;12537569;12537572;12537573;12537574;12538650;14668387;15574598;15986206;16110336;17569856;17569867;18327897;23723094;25589440;26109356;26109357", "class_list": "", "function": "Phosphorylates 'Ser-10' of histone H3. May regulate gene expression by establishing or maintaining the structure of more open chromatin regions. Also required for normal polytene chromosome structure, for oogenesis and for viability throughout development. Regulates the structure of polytene chromosomes in salivary glands. May phosphorylate 'Ser-1' of histone H2A., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5RJL0;Q0E8F9;Q95RY3", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0035175 histone H3S10 kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0000228 nuclear chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0043687 post-translational protein modification;GO:0006355 regulation of DNA-templated transcription;GO:0000723 telomere maintenance;GO:0046777 protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9V3I5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VP05-1", "uniprot_id": [ { "id": "MED1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VP05", "type": "external" } ], "mass": 149531.0, "length": 1475, "protein_name": "Mediator of RNA polymerase II transcription subunit 1", "gene_name": "MED1", "organism": "Fruit fly", "refseq_name": "mediator complex subunit 1, isoform A", "refseq_ac": [ { "id": "NP_649341", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649341", "type": "external" } ], "gene_names_uniprotkb": "MED1; CG7162; Dmel\\CG7162; Dmel_CG7162; FBgn0037109; Med1; TRAP220; Trap220; dTRAP220", "gene_names_refseq": "CG7162; Dmel\\CG7162; FBgn0037109; MED1; Med1/SOP3/TRAP220; Med1; Trap220; dTRAP220", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 1; Mediator complex subunit 1; dTRAP220", "protein_names_refseq": "CG7162-PA; MED1-PA; mediator complex subunit 1, isoform A; mediator", "tax_id": 7227, "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (dme:Dmel_CG7162); (R-DME-383280); (R-DME-400206); (R-DME-9018519); (R-DME-9707564); (R-DME-9841922)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;16751183;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "B5RJH3;Q9GYW7", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VP05-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VXK0-1", "uniprot_id": [ { "id": "NIPSN_DROME", "url": "https://www.uniprot.org/uniprot/Q9VXK0", "type": "external" } ], "mass": 31965.0, "length": 273, "protein_name": "Protein NipSnap", "gene_name": "Nipsnap", "organism": "Fruit fly", "refseq_name": "nipsnap, isoform F", "refseq_ac": [ { "id": "NP_001285316", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285316", "type": "external" } ], "gene_names_uniprotkb": "Nipsnap; CG9212; Dmel\\CG9212; Dmel_CG9212", "gene_names_refseq": "CG9212; Dmel\\CG9212; Nipsnap", "protein_names_uniprotkb": "Protein NipSnap", "protein_names_refseq": "CG9212-PF; Nipsnap-PF; nipsnap, isoform F", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9212); (R-DME-9013407)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V4K8;Q9U5W0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VXK0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VXY7-1", "uniprot_id": [ { "id": "LSD2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VXY7", "type": "external" } ], "mass": 38229.0, "length": 352, "protein_name": "Lipid storage droplets surface-binding protein 2", "gene_name": "Lsd-2", "organism": "Fruit fly", "refseq_name": "lipid storage droplet-2, isoform A", "refseq_ac": [ { "id": "NP_572996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572996", "type": "external" } ], "gene_names_uniprotkb": "Lsd-2; 145098_at; CG9057; DmPLIN2; Dmel\\CG9057; Dmel_CG9057; LSD-2; LSD2; LSD; LSP-2; Lsd2; PLIN2; Plin2; dPlin2; dmPLIN2; lsd-2; lsd2; plin2", "gene_names_refseq": "145098_at; CG9057; DmPLIN2; Dmel\\CG9057; LSD-2; LSD2; LSD; LSP-2; Lsd-2; Lsd2; PLIN2; Plin2; dPlin2; dmPLIN2; lsd-2; lsd2; plin2", "protein_names_uniprotkb": "Lipid storage droplets surface-binding protein 2; Lsd2", "protein_names_refseq": "CG9057-PA; Lipid-storage Droplet-2; Lsd-2-PA; Perilipin2; lipid storage droplet 2 gene; lipid storage droplet 2; lipid storage droplet protein 2; lipid storage droplet-2, isoform A; lipid storage droplet-2; perilipin-2; perilipin", "tax_id": 7227, "disease": "familial partial lipodystrophy type 4 (Disease Ontology:DOID:0070205); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG9057)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10731132;12077142;12537568;12537569;12537572;12537573;12537574;12676093;14550535;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Essential for embryogenesis. Required for normal deposition of neutral lipids in the oocyte., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005829 cytosol", "go_biological_process": "GO:0006869 lipid transport;GO:0050995 negative regulation of lipid catabolic process;GO:0010890 positive regulation of triglyceride storage;GO:0019915 lipid storage;GO:0034389 lipid droplet organization", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q9VXY7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2PE14-1", "uniprot_id": [ { "id": "ZCHC8_DROME", "url": "https://www.uniprot.org/uniprot/Q2PE14", "type": "external" } ], "mass": 62405.0, "length": 553, "protein_name": "Zinc finger CCHC domain-containing protein 8 homolog", "gene_name": "CG4622", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": [ { "id": "NP_001033971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033971", "type": "external" } ], "gene_names_uniprotkb": "CG4622", "gene_names_refseq": "CG4622; Dmel\\CG4622; Itp; ZCCHC8; ZCHC8; dZcchc8", "protein_names_uniprotkb": "Zinc finger CCHC domain-containing protein 8 homolog", "protein_names_refseq": "CG4622-PC; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4622); (R-DME-9930044)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18327897", "class_list": "", "function": "Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. May be involved in pre-mRNA splicing., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BHV6;Q9W153", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0006396 RNA processing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q2PE14-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V516-1", "uniprot_id": [ { "id": "DRC7_DROME", "url": "https://www.uniprot.org/uniprot/Q4V516", "type": "external" } ], "mass": 105242.0, "length": 897, "protein_name": "Coiled-coil domain-containing protein lobo", "gene_name": "lobo", "organism": "Fruit fly", "refseq_name": "lost boys", "refseq_ac": [ { "id": "NP_001036757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036757", "type": "external" } ], "gene_names_uniprotkb": "lobo; CG13662", "gene_names_refseq": "CG13661; CG13662; CG34110; Dmel\\CG34110; lobo", "protein_names_uniprotkb": "Coiled-coil domain-containing protein lobo; Lost boys protein", "protein_names_refseq": "CG34110-PC; lobo-PC; lost boys", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG34110)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;17534367;21289096", "class_list": "", "function": "Key component of the nexin-dynein regulatory complex (N-DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility (By similarity). Involved in sperm motility. Required for the sperm to enter in the coiled storage seminal receptacle (SR) tubule (PubMed:21289096)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031514 motile cilium;GO:0005930 axoneme", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0046693 sperm storage", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q4V516-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4V5A3-1", "uniprot_id": [ { "id": "UNPG_DROME", "url": "https://www.uniprot.org/uniprot/Q4V5A3", "type": "external" } ], "mass": 52230.0, "length": 485, "protein_name": "Homeobox protein unplugged", "gene_name": "unpg", "organism": "Fruit fly", "refseq_name": "unplugged", "refseq_ac": [ { "id": "NP_477146", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477146", "type": "external" } ], "gene_names_uniprotkb": "unpg; CG1650; unp", "gene_names_refseq": "1912; CG1650; Dmel\\CG1650; Gbx; anon-45C; unpg; unp; upg", "protein_names_uniprotkb": "Homeobox protein unplugged", "protein_names_refseq": "CG1650-PA; unpg-PA; unplugged", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1650)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;12702651;8582298", "class_list": "", "function": "Plays a regulatory role in neural branching of the tracheae: segment-specific aspects of these neural branching patterns appear to be generated by homeotic regulation of expression. May have a role with oc/otd in the postembryonic development of the brain., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q24136", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0007420 brain development;GO:0051960 regulation of nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q4V5A3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q59DY6-1", "uniprot_id": [ { "id": "LEDL2_DROME", "url": "https://www.uniprot.org/uniprot/Q59DY6", "type": "external" } ], "mass": 21380.0, "length": 186, "protein_name": "C-type lectin 37Da", "gene_name": "lectin-37Da", "organism": "Fruit fly", "refseq_name": "lectin-37Da, isoform A", "refseq_ac": [ { "id": "NP_001014489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014489", "type": "external" } ], "gene_names_uniprotkb": "lectin-37Da; CG33532; DL2", "gene_names_refseq": "AC 007082B; AC007082b; CG33532; CG9978; DL2; Dmel\\CG33532; lectin-37Da", "protein_names_uniprotkb": "C-type lectin 37Da", "protein_names_refseq": "CG33532-PA; Lectin-37 Da; drosophila lectin 2; lectin-37Da, isoform A; lectin-37Da-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33532)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;16475980;17287021", "class_list": "", "function": "Galactose-specific lectin that displays calcium-dependent activity (PubMed:16475980, PubMed:17287021). Binds to the surface of hemocytes and enhances hemocyte encapsulation and melanization (PubMed:17287021). This is likely by interacting with carbohydrates on the surface of the hemocytes (PubMed:17287021). Also displays agglutination activity against the Gram-negative bacterium E.coli (PubMed:17287021)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4V3L4;Q65Y01", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0038187 pattern recognition receptor activity;GO:0005534 galactose binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0035006 melanization defense response;GO:0035010 encapsulation of foreign target", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q59DY6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q59DY8-1", "uniprot_id": [ { "id": "Q59DY8_DROME", "url": "https://www.uniprot.org/uniprot/Q59DY8", "type": "external" } ], "mass": 18404.0, "length": 157, "protein_name": "RING-type domain-containing protein", "gene_name": "Dmel\\CG33552", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_001014488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014488", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG33552; CG33552; Dmel_CG33552", "gene_names_refseq": "CG33552; Dmel\\CG33552", "protein_names_uniprotkb": "RING-type domain-containing protein", "protein_names_refseq": "CG33552-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33552)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0036297 interstrand cross-link repair", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q59DY8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VNA4-1", "uniprot_id": [ { "id": "Y1161_DROME", "url": "https://www.uniprot.org/uniprot/Q9VNA4", "type": "external" } ], "mass": 24654.0, "length": 227, "protein_name": "Uncharacterized protein CG1161", "gene_name": "Dmel\\CG1161", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": [ { "id": "NP_649528", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649528", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG1161; CG1161; Dmel_CG1161", "gene_names_refseq": "CG1161; Dmel\\CG1161", "protein_names_uniprotkb": "Uncharacterized protein CG1161", "protein_names_refseq": "CG1161-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1161)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005765 lysosomal membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VNA4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q70PY2-1", "uniprot_id": [ { "id": "PGSB1_DROME", "url": "https://www.uniprot.org/uniprot/Q70PY2", "type": "external" } ], "mass": 20998.0, "length": 190, "protein_name": "Peptidoglycan-recognition protein SB1", "gene_name": "PGRP-SB1", "organism": "Fruit fly", "refseq_name": "peptidoglycan recognition protein SB1", "refseq_ac": [ { "id": "NP_648917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648917", "type": "external" } ], "gene_names_uniprotkb": "PGRP-SB1; CG9681", "gene_names_refseq": "142657_at; CG9681; Dmel\\CG9681; PGRP SB1; PGRP-SB1; PGRP-SB", "protein_names_uniprotkb": "Peptidoglycan-recognition protein SB1; 3.5.1.28", "protein_names_refseq": "CG9681-PA; PGRP-SB1-PA; Peptidoglycan-recognition protein-SB1 precursor; peptidoglycan receptor protein SB1; peptidoglycan recognition protein SB1; peptidoglycan recognition; protein-like", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9681); (R-DME-6798695); (R-DME-6803157)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;11106397;12537572;14738318;17046713", "class_list": "", "function": "N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN), preferentially DAP-type PGNs. Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0FIQ1;A0JQ53;Q4V3W6;Q70PY3;Q70PY4;Q70PY7;Q9VV97", "ec_number_list": [ { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.5.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.28", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "3.4.17.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.13", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0008745 N-acetylmuramoyl-L-alanine amidase activity;GO:0008270 zinc ion binding;GO:0016019 peptidoglycan immune receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006955 immune response;GO:0045087 innate immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0009253 peptidoglycan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q70PY2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q76NQ1-1", "uniprot_id": [ { "id": "RHDF1_DROME", "url": "https://www.uniprot.org/uniprot/Q76NQ1", "type": "external" } ], "mass": 157302.0, "length": 1429, "protein_name": "Inactive rhomboid protein 1", "gene_name": "rho-5", "organism": "Fruit fly", "refseq_name": "rhomboid-5", "refseq_ac": [ { "id": "NP_995679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_995679", "type": "external" } ], "gene_names_uniprotkb": "rho-5; CG33304; iRhom", "gene_names_refseq": "CG33304; CG5364; CT17046; Dmel\\CG33304; Rho-related[31D10]; iRhom1; iRhom; rho-5", "protein_names_uniprotkb": "Inactive rhomboid protein 1; Rhomboid family protein rhomboid-5; iRhom1", "protein_names_refseq": "CG33304-PA; rho-5-PA; rhomboid-5", "tax_id": 7227, "disease": "palmoplantar keratoderma-esophageal carcinoma syndrome (Disease Ontology:DOID:0111506)", "pathway": " (dme:Dmel_CG33304)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;21439629;26109405", "class_list": "", "function": "Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor (PubMed:21439629). Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration (PubMed:21439629). Involved in clearance of aggregation-prone proteins, probably by promoting assembly of the proteosome, positively regulating its activity (PubMed:26109405)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E1NZB2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport;GO:0050708 regulation of protein secretion;GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway;GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness;GO:0042058 regulation of epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q76NQ1-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7JR49-1", "uniprot_id": [ { "id": "VAS1_DROME", "url": "https://www.uniprot.org/uniprot/Q7JR49", "type": "external" } ], "mass": 41124.0, "length": 379, "protein_name": "V-type proton ATPase subunit S1", "gene_name": "VhaAC45", "organism": "Fruit fly", "refseq_name": "vacuolar H[+] ATPase AC45 accessory subunit, isoform B", "refseq_ac": [ { "id": "NP_610470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610470", "type": "external" } ], "gene_names_uniprotkb": "VhaAC45; ATP6AP1; CG8029", "gene_names_refseq": "ATP6AP1; CG8029; Dmel\\CG8029; VhaAC45; anon-WO0118547.117; l(2)SH1634; l(2)SH2 1634; vhaAC45", "protein_names_uniprotkb": "V-type proton ATPase subunit S1; Vacuolar H(+) ATPase AC45 accessory subunit", "protein_names_refseq": "CG8029-PB; VhaAC45-PB; lethal (2) SH1634; vacuolar H[+] ATPase AC45 accessory subunit, isoform B; vacuolar H[+] ATPase accessory protein AC45", "tax_id": 7227, "disease": "immunodeficiency 47 (Disease Ontology:DOID:0112002)", "pathway": " (dme:Dmel_CG8029); (R-DME-77387); (R-DME-917977); (R-DME-983712)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10731132;12537572;29127204;29995586", "class_list": "", "function": "Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0033176 proton-transporting V-type ATPase complex;GO:0005789 endoplasmic reticulum membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex", "go_biological_process": "GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly;GO:0030641 regulation of cellular pH", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7JR49-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7JUX9-1", "uniprot_id": [ { "id": "MRRP1_DROME", "url": "https://www.uniprot.org/uniprot/Q7JUX9", "type": "external" } ], "mass": 52529.0, "length": 446, "protein_name": "Mitochondrial ribonuclease P protein 1 homolog", "gene_name": "rswl", "organism": "Fruit fly", "refseq_name": "roswell", "refseq_ac": [ { "id": "NP_611335", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611335", "type": "external" } ], "gene_names_uniprotkb": "rswl; CG5190; MRPP1; trmt10c", "gene_names_refseq": "CG5190; Dmel\\CG5190; MRPP1; TRMT10C; rswl", "protein_names_uniprotkb": "Mitochondrial ribonuclease P protein 1 homolog; 2.1.1.-; Mitochondrial RNase P protein 1; Protein roswell; RNA (guanine-9-)-methyltransferase domain-containing protein 1; tRNA methyltransferase 10 homolog C", "protein_names_refseq": "CG5190-PA; roswell; rswl-PA", "tax_id": 7227, "disease": "combined oxidative phosphorylation deficiency 30 (Disease Ontology:DOID:0111471)", "pathway": " (dme:Dmel_CG5190)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;18327897;27131785;34199774;35663400", "class_list": "", "function": "Mitochondrial tRNA N1-methyltransferase involved in mitochondrial tRNA maturation (PubMed:27131785, PubMed:34199774, PubMed:35663400). Component of mitochondrial ribonuclease P, a complex composed of rswl/MRPP1, scu/MRPP2 and mldr/MRPP3., which cleaves tRNA molecules in their 5'-ends (PubMed:27131785). Essential for the structural and functional integrity of mitochondria (PubMed:27131785, PubMed:34199774, PubMed:35663400). Function is essential for pupal development (PubMed:34199774, PubMed:35663400)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding;GO:0052905 tRNA (guanosine(9)-N1)-methyltransferase activity;GO:0160106 tRNA (adenine(9)-N1)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0030678 mitochondrial ribonuclease P complex", "go_biological_process": "GO:0070131 positive regulation of mitochondrial translation;GO:0070901 mitochondrial tRNA methylation;GO:0090646 mitochondrial tRNA processing;GO:0097745 mitochondrial tRNA 5'-end processing;GO:0140040 mitochondrial polycistronic RNA processing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q7JUX9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7JXV9-1", "uniprot_id": [ { "id": "VPS25_DROME", "url": "https://www.uniprot.org/uniprot/Q7JXV9", "type": "external" } ], "mass": 20608.0, "length": 174, "protein_name": "Vacuolar protein-sorting-associated protein 25", "gene_name": "Vps25", "organism": "Fruit fly", "refseq_name": "vacuolar protein sorting 25", "refseq_ac": [ { "id": "NP_610398", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610398", "type": "external" } ], "gene_names_uniprotkb": "Vps25; CG14750; l(2)44Db", "gene_names_refseq": "CG14750; Dmel\\CG14750; ESCRT-II; ESCRT-I; VPS25; Vps25; dVps25; l(2)44Db; l(2)k08904; vps25", "protein_names_uniprotkb": "Vacuolar protein-sorting-associated protein 25; ESCRT-II complex subunit VPS25; Vacuolar protein sorting 25", "protein_names_refseq": "CG14750-PA; Vps25-PA; lethal (2) 44Db; vacuolar protein sorting 25; vesicle protein sorting 25", "tax_id": 7227, "disease": "cancer (Disease Ontology:DOID:162); carcinoma (Disease Ontology:DOID:305)", "pathway": " (dme:Dmel_CG14750); (R-DME-917729)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537569;12537572;14605208;16256743;16256745;16611691;17088062;17268469;17935992;19132102", "class_list": "", "function": "Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). Seems to function as a tumor suppressor by regulating Notch trafficking, hence preventing non-autonomous overproliferation. May be involved in the regulation of autophagy. ESCRT-II interacts with bicoid mRNA, which is required for the anterior localization of bicoid mRNA in the developing egg., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0000814 ESCRT II complex", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0097352 autophagosome maturation;GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0050680 negative regulation of epithelial cell proliferation;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7JXV9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7JYV7-1", "uniprot_id": [ { "id": "KAD6_DROME", "url": "https://www.uniprot.org/uniprot/Q7JYV7", "type": "external" } ], "mass": 20463.0, "length": 175, "protein_name": "Adenylate kinase isoenzyme 6 homolog", "gene_name": "Ak6", "organism": "Fruit fly", "refseq_name": "adenylate kinase 6", "refseq_ac": [ { "id": "NP_610797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610797", "type": "external" } ], "gene_names_uniprotkb": "Ak6; CG8816", "gene_names_refseq": "Ak6; CG8816; DAK6; Dmel\\CG8816", "protein_names_uniprotkb": "Adenylate kinase isoenzyme 6 homolog; 2.7.4.3; AK/ATPase; AK6; DAK6; Dual activity adenylate kinase/ATPase", "protein_names_refseq": "Ak6-PA; CG8816-PA; adenylate kinase 6", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8816); (R-DME-499943)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18294127", "class_list": "", "function": "Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates (PubMed:18294127). Also has ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis (By similarity). AMP is the best phosphate acceptor, and CMP is also a good substrate. All nucleoside triphosphates ATP, TTP, CTP, GTP, and UTP are accepted as phosphate donors. ATP is the best phosphate donor (PubMed:18294127)., [UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7JYV7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7K0D8-1", "uniprot_id": [ { "id": "NUP50_DROME", "url": "https://www.uniprot.org/uniprot/Q7K0D8", "type": "external" } ], "mass": 59434.0, "length": 564, "protein_name": "Nuclear pore complex protein Nup50", "gene_name": "Nup50", "organism": "Fruit fly", "refseq_name": "nucleoporin 50kD", "refseq_ac": [ { "id": "NP_610355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610355", "type": "external" } ], "gene_names_uniprotkb": "Nup50; CG2158", "gene_names_refseq": "CG2158; Dmel\\CG2158; NUP50; Nup50; Nup; nup50", "protein_names_uniprotkb": "Nuclear pore complex protein Nup50; 50 kDa nucleoporin", "protein_names_refseq": "CG2158-PA; Nup50-PA; nuclear pore protein 50; nucleoporin 50kD; nucleoporin 50", "tax_id": 7227, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dme:Dmel_CG2158); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236); (R-DME-1855170); (R-DME-1855196); (R-DME-1855229); (R-DME-3108214); (R-DME-3301854); (R-DME-3371453); (R-DME-4085377); (R-DME-4551638); (R-DME-4615885)", "pathway_count": 14, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;20144760;28604694;33925313;40245499", "class_list": "", "function": "Component of the nuclear pore complex that has a direct role in nuclear protein import (By similarity). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (By similarity). Binds to transcriptionally active chromatin sites when located in the nucleoplasm and is involved in transcriptional activation (PubMed:20144760)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006913 nucleocytoplasmic transport;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051028 mRNA transport;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q7K0D8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7K4Z4-1", "uniprot_id": [ { "id": "IMD_DROME", "url": "https://www.uniprot.org/uniprot/Q7K4Z4", "type": "external" } ], "mass": 29899.0, "length": 273, "protein_name": "Protein immune deficiency", "gene_name": "imd", "organism": "Fruit fly", "refseq_name": "immune deficiency, isoform B", "refseq_ac": [ { "id": "NP_001286572", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286572", "type": "external" } ], "gene_names_uniprotkb": "imd; CG5576", "gene_names_refseq": "BG5; CG5576; Dmel\\CG5576; IMD; IMd; Imd; anon-WO0172774.166; dsIMD; imd; shadok", "protein_names_uniprotkb": "Protein immune deficiency", "protein_names_refseq": "CG5576-PB; imd-PB; immune deficiency, isoform B; immune deficiency; immune deficient; immunodeficiency", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5576); (R-DME-214397); (R-DME-214399); (R-DME-214411); (R-DME-214416)", "pathway_count": 5, "publication_count": 20, "publication_id_list": "10731132;10934188;11018014;11266367;11269502;11703941;12433364;12537569;12537572;12732719;15657141;16428381;16767093;19763182;19837371;20122400;23919485;25027767;7568155;8808632", "class_list": "", "function": "Essential for the imd/NF-kappa-B (Imd) humoral and epithelial immune response to Gram-negative bacteria (PubMed:11266367, PubMed:12433364, PubMed:7568155, PubMed:8808632). Functions as an adapter protein that transduces immunity signals from the activation of pathogen recognition receptors (PRRs) by bacterial infection to the Imd signaling pathway (PubMed:11269502, PubMed:11703941, PubMed:12433364, PubMed:20122400, PubMed:7568155). Binding of diaminopimelic acid-type (DAP-type) bacterial peptidoglycans (PGN) causes multimerization or clustering of PGRP receptors which activate the Imd cascade probably by recruiting imd, Fadd and Dredd to the receptor complex (PubMed:11269502, PubMed:12433364, PubMed:20122400). Once in proximity, Dredd cleaves imd in a Fadd-dependent manner to enable its association and activation by the ubiquitin E3-ligase DIAP2 (PubMed:20122400). The activated form of imd recruits and activates the Tab2/Tak1 complex thus acting upstream of the IKK complex (ird5 and key) to activate Rel and induce the expression of antimicrobial peptides such as Def, Dpt and Cecropin (PubMed:11266367, PubMed:11703941, PubMed:12433364, PubMed:19837371, PubMed:20122400, PubMed:7568155, PubMed:8808632). Also able to inhibit the viral replication of the Sindbis virus (PubMed:19763182). Involved in promoting the polyubiquitination and stability of faf which in turn, regulates the Imd pathway by controlling imd polyubiquitination and/or stability; they may therefore form a regulatory feedback mechanism within the Imd pathway (PubMed:23919485). Not required for the cuticle melanization immune response to bacterial challenge (PubMed:11266367)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9NHG0", "ec_number_list": [], "go_molecular_function": "GO:0070513 death domain binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006955 immune response;GO:0019731 antibacterial humoral response;GO:0035556 intracellular signal transduction;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q7K4Z4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7K738-1", "uniprot_id": [ { "id": "UBC10_DROME", "url": "https://www.uniprot.org/uniprot/Q7K738", "type": "external" } ], "mass": 17907.0, "length": 154, "protein_name": "Ubiquitin-conjugating enzyme E2-18 kDa", "gene_name": "Ubc10", "organism": "Fruit fly", "refseq_name": "ubiquitin conjugating enzyme 10", "refseq_ac": [ { "id": "NP_477414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477414", "type": "external" } ], "gene_names_uniprotkb": "Ubc10; CG5788; ubcD10", "gene_names_refseq": "CG5788; Dmel\\CG5788; EG:52C10.4; Ubc10; UbcD10; ubcD10; ubc", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2-18 kDa; 2.3.2.23; Ubiquitin conjugating enzyme 10", "protein_names_refseq": "CG5788-PA; Ubc10-PA; ubiquitin conjugating enzyme 10", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5788); (R-DME-5205685); (R-DME-8866652); (R-DME-983168)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10731132;10880484;12537572;21900267;27702987;29689197", "class_list": "", "function": "Ubiquitin-conjugating enzyme E2 that acts with the RBR family ligases LUBEL, ari-1 and possibly parkin (PubMed:21900267, PubMed:27702987, PubMed:29689197). Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (By similarity). Appears to be involved in the selective degradation of short-lived and abnormal proteins (PubMed:21900267, PubMed:27702987, PubMed:29689197). Functions with ari-1 to control the subcellular localization and morphology of muscle nuclei (myonuclei) by regulating the protein levels and distribution of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex (PubMed:29689197). Functions by mediating the monoubiquitination of the LINC complex subunit koi leading to its subsequent proteasomal degradation (PubMed:29689197). Likely to function with ari-1 to control metamorphosis by regulating the proteins levels of EcR isoform A (ECR-A) and its heterodimeric partner usp, via the ubiquitination and subsequent degradation of ECR-A (PubMed:21900267). Able to function with LUBEL to mediate 'Lys-63'- and linear 'Met-1'-linked polyubiquitin involved in the heat stress response (PubMed:27702987)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0016874 ligase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0097039 protein linear polyubiquitination;GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q7K738-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7K7A9-1", "uniprot_id": [ { "id": "FEN1_DROME", "url": "https://www.uniprot.org/uniprot/Q7K7A9", "type": "external" } ], "mass": 42948.0, "length": 385, "protein_name": "Flap endonuclease 1", "gene_name": "Fen1", "organism": "Fruit fly", "refseq_name": "flap endonuclease 1", "refseq_ac": [ { "id": "NP_523765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523765", "type": "external" } ], "gene_names_uniprotkb": "Fen1; CG8648", "gene_names_refseq": "CG8648; DmFEN-1; Dmel\\CG8648; EG:EG0003.3; FEN1; Fen1; fen1", "protein_names_uniprotkb": "Flap endonuclease 1; 3.1.-.-; FEN-1; Flap structure-specific endonuclease 1", "protein_names_refseq": "CG8648-PA; Fen1-PA; flap endonuclease 1; flap endonuclease-1", "tax_id": 7227, "disease": "breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162)", "pathway": " (dme:Dmel_CG8648); (R-DME-5651801); (R-DME-5685939); (R-DME-69166)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10731132;10731137;12537572", "class_list": "", "function": "Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0030145 manganese ion binding;GO:0004519 endonuclease activity;GO:0004523 RNA-DNA hybrid ribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion", "go_biological_process": "GO:0006284 base-excision repair;GO:0043137 DNA replication, removal of RNA primer", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7K7A9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KBL8-1", "uniprot_id": [ { "id": "MED29_DROME", "url": "https://www.uniprot.org/uniprot/Q7KBL8", "type": "external" } ], "mass": 21147.0, "length": 188, "protein_name": "Mediator of RNA polymerase II transcription subunit 29", "gene_name": "ix", "organism": "Fruit fly", "refseq_name": "intersex", "refseq_ac": [ { "id": "NP_610677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610677", "type": "external" } ], "gene_names_uniprotkb": "ix; CG13201; MED29", "gene_names_refseq": "CG13201; Dmel\\CG13201; IX; MED29; Med29; ix", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 29; Mediator complex subunit 29; Protein intersex", "protein_names_refseq": "CG13201-PA; intersex; ix-PA; mediator complex subunit 29", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13201)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12361959;12537572", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for female somatic sexual development., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0IGZ7", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex", "go_biological_process": "GO:0007530 sex determination;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7KBL8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KIN0-1", "uniprot_id": [ { "id": "TOLL7_DROME", "url": "https://www.uniprot.org/uniprot/Q7KIN0", "type": "external" } ], "mass": 160950.0, "length": 1446, "protein_name": "Toll-like receptor 7", "gene_name": "Toll-7", "organism": "Fruit fly", "refseq_name": "Toll-7", "refseq_ac": [ { "id": "NP_523797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523797", "type": "external" } ], "gene_names_uniprotkb": "Toll-7; CG8595", "gene_names_refseq": "CG8595; CT24947; Dmel\\CG8595; TOLL 7; Tl-7; Toll 7; Toll-7; Toll7; Toll; dTLR7; dToll7; toll-7; toll", "protein_names_uniprotkb": "Toll-like receptor 7", "protein_names_refseq": "CG8595-PA; Toll-7-PA; Toll-7; Toll-like; Toll7; toll receptor", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8595)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10731132;10973475;12537572;12617819;16120803;21158756;22464169;23892553;25741726", "class_list": "", "function": "Toll-related receptor which binds to the neurotrophins NT1 and spz5 (PubMed:10973475, PubMed:23892553). Essential for antiviral autophagy, it detects and binds to the vesicular stomatitis virus (vsv) following infection (PubMed:22464169). This role is likely to be independent of the canonical Toll, immune deficiency, and JAK-STAT signaling pathways (PubMed:22464169). Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe (PubMed:25741726). Function in the Va1d ORNs is necessary and sufficient for correct targeting to their partner PN dendrites (PubMed:25741726). Also involved in the targeting of other classes of ORN axons (PubMed:25741726). Functions with Toll-6 to regulate motor axon targeting and neuronal survival in the central nervous system (CNS) (PubMed:23892553). May be an upstream component of the NF-kappa-B (rel) regulatory cascade (PubMed:23892553)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E1NZA7;Q2XXU8", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0038187 pattern recognition receptor activity;GO:0005030 neurotrophin receptor activity;GO:0046790 virion binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0010508 positive regulation of autophagy;GO:0007411 axon guidance;GO:0008063 Toll signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q7KIN0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KN79-1", "uniprot_id": [ { "id": "LTV1_DROME", "url": "https://www.uniprot.org/uniprot/Q7KN79", "type": "external" } ], "mass": 57223.0, "length": 493, "protein_name": "Protein LTV1 homolog", "gene_name": "LTV1", "organism": "Fruit fly", "refseq_name": "LTV1 ribosome biogenesis factor, isoform B", "refseq_ac": [ { "id": "NP_001286300", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286300", "type": "external" } ], "gene_names_uniprotkb": "LTV1; CG7686", "gene_names_refseq": "BcDNA:LD21529; CG7686; Dmel\\CG7686; LTV1", "protein_names_uniprotkb": "Protein LTV1 homolog; Low temperature viability protein 1; Ribosome biogenesis factor LTV1", "protein_names_refseq": "CG7686-PB; LTV1 ribosome biogenesis factor, isoform B; LTV1-PB; Low temperature viability protein 1", "tax_id": 7227, "disease": "inflammatory poikiloderma with hair abnormalities and acral keratoses (Disease Ontology:DOID:0070510)", "pathway": " (dme:Dmel_CG7686)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;10731138;12537572;18327897;25858587", "class_list": "", "function": "Necessary for the biogenesis of 40S ribosome subunits by regulating pre-rRNA processing. Non-ribosomal factor required for efficient nuclear export of the ribosomal 40S subunit. Necessary for endoreplication driven by Myc., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4LF59", "ec_number_list": [], "go_molecular_function": "GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0030688 preribosome, small subunit precursor", "go_biological_process": "GO:0006364 rRNA processing;GO:0000056 ribosomal small subunit export from nucleus;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7KN79-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KNM2-1", "uniprot_id": [ { "id": "Q7KNM2_DROME", "url": "https://www.uniprot.org/uniprot/Q7KNM2", "type": "external" } ], "mass": 18148.0, "length": 159, "protein_name": "Lesswright, isoform A; Lesswright, isoform B; Lesswright, isoform C; Lesswright, isoform D", "gene_name": "lwr", "organism": "Fruit fly", "refseq_name": "lesswright, isoform C", "refseq_ac": [ { "id": "NP_001259833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259833", "type": "external" } ], "gene_names_uniprotkb": "lwr; CG3018; DUbc9; DmUbc9; Dmel\\CG3018; Dmel_CG3018; Dmubc9; FBgn0010602; Iwr; Lwr; UBC9; Ubc 9; Ubc-9; Ubc9; UbcD9; dUBC9; dUbc9; dip4; hbl; i105; i56; l(2)01519; l(2)02858; l(2)05486; l(2)05487; semi; ubc9", "gene_names_refseq": "CG3018; DUbc9; DmUbc9; Dmel\\CG3018; Dmubc9; FBgn0010602; Iwr; Lwr; UBC9; Ubc 9; Ubc-9; Ubc9/Lwr; Ubc9; UbcD9; dUBC9; dUbc9; dip4; hbl; i105; i56; l(2)01519; l(2)02858; l(2)05486; l(2)05487; lwr; semi; ubc9", "protein_names_uniprotkb": "Lesswright, isoform A; Lesswright, isoform B; Lesswright, isoform C; Lesswright, isoform D", "protein_names_refseq": "CG3018-PC; hunchback-like; lesswright, isoform C; lesswright; leswright; lwr-PC; semushi; ubiquitin conjugating enzyme 9; ubiquitin-conjugating enzyme 9", "tax_id": 7227, "disease": "urinary bladder cancer (Disease Ontology:DOID:11054); dilated cardiomyopathy (Disease Ontology:DOID:12930); cancer (Disease Ontology:DOID:162); ovarian cancer (Disease Ontology:DOID:2394); hematologic cancer (Disease Ontology:DOID:2531)", "pathway": " (dme:Dmel_CG3018); (R-DME-196791); (R-DME-3108214); (R-DME-3232118); (R-DME-3899300); (R-DME-4085377); (R-DME-4090294); (R-DME-4551638); (R-DME-4570464); (R-DME-4615885); (R-DME-4755510); (R-DME-5696395)", "pathway_count": 12, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0031072 heat shock protein binding;GO:0061656 SUMO conjugating enzyme activity;GO:0033134 ubiquitin activating enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000779 condensed chromosome, centromeric region;GO:0000940 outer kinetochore", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0016321 female meiosis chromosome segregation;GO:0016925 protein sumoylation;GO:0050821 protein stabilization;GO:0007143 female meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7KNM2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KRR5-1", "uniprot_id": [ { "id": "NGLY1_DROME", "url": "https://www.uniprot.org/uniprot/Q7KRR5", "type": "external" } ], "mass": 73316.0, "length": 631, "protein_name": "Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase", "gene_name": "Pngl", "organism": "Fruit fly", "refseq_name": "PNGase-like, isoform A", "refseq_ac": [ { "id": "NP_610192", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610192", "type": "external" } ], "gene_names_uniprotkb": "Pngl; CG7865; PNGase", "gene_names_refseq": "CG7865; Dmel\\CG7865; NGLY1; PNGase; Png1; Pngl; dNGLY1; ngly1; png1; pngl", "protein_names_uniprotkb": "Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; 3.5.1.52; Peptide:N-glycanase", "protein_names_refseq": "CG7865-PA; PNGase-like, isoform A; PNGase; Pngl-PA", "tax_id": 7227, "disease": "congenital disorder of deglycosylation 1 (Disease Ontology:DOID:0060728); congenital disorder of deglycosylation (Disease Ontology:DOID:0060991)", "pathway": " (dme:Dmel_CG7865); (R-DME-532668)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;10831608;12537569;12537572;18327897", "class_list": "", "function": "Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IGW3;Q8MRV8;Q9NBD5;Q9V9J5", "ec_number_list": [ { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.5.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.52", "type": "external" } ], "go_molecular_function": "GO:0000224 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007495 visceral mesoderm-endoderm interaction involved in midgut development;GO:0030513 positive regulation of BMP signaling pathway;GO:0006516 glycoprotein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7KRR5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KSU5-1", "uniprot_id": [ { "id": "Q7KSU5_DROME", "url": "https://www.uniprot.org/uniprot/Q7KSU5", "type": "external" } ], "mass": 36293.0, "length": 313, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG33325", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_996182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996182", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG33325; CG33325; Dmel_CG33325", "gene_names_refseq": "CG33325; Dmel\\CG33325", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG33325-PB; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33325)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7KSU5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KT25-1", "uniprot_id": [ { "id": "Q7KT25_DROME", "url": "https://www.uniprot.org/uniprot/Q7KT25", "type": "external" } ], "mass": 23781.0, "length": 205, "protein_name": "Uncharacterized protein", "gene_name": "38B.19", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_610027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610027", "type": "external" } ], "gene_names_uniprotkb": "38B.19; CG13970; Dmel\\CG13970; Dmel_CG13970", "gene_names_refseq": "38B.19; CG13970; Dmel\\CG13970", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG13970-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13970)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7KT25-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KTX7-1", "uniprot_id": [ { "id": "PRKN_DROME", "url": "https://www.uniprot.org/uniprot/Q7KTX7", "type": "external" } ], "mass": 54105.0, "length": 482, "protein_name": "E3 ubiquitin-protein ligase parkin", "gene_name": "park", "organism": "Fruit fly", "refseq_name": "parkin, isoform B", "refseq_ac": [ { "id": "NP_730600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_730600", "type": "external" } ], "gene_names_uniprotkb": "park; CG10523; parkin", "gene_names_refseq": "AAN12155.1; CG10523; Dmel\\CG10523; Dpark; PARK2; PARKIN; PARK; PK; Parkin; Park; SD01679; dPARKIN; dParkin; dparkin; dpark; dpk; park1; park; pk; prkn", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase parkin; 2.3.2.31", "protein_names_refseq": "CG10523-PB; D-parkin; dparkin; ortholog of PRKN; park-PB; parkin F; parkin, isoform B", "tax_id": 7227, "disease": "opportunistic bacterial infectious disease (Disease Ontology:DOID:0050340); cardiomyopathy (Disease Ontology:DOID:0050700); Parkinson's disease 2 (Disease Ontology:DOID:0060368); Parkinson's disease 6 (Disease Ontology:DOID:0060369); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); Alzheimer's disease (Disease Ontology:DOID:10652); Lewy body dementia (Disease Ontology:DOID:12217); lung cancer (Disease Ontology:DOID:1324); Parkinson's disease (Disease Ontology:DOID:14330); multiple sclerosis (Disease Ontology:DOID:2377); ovarian cancer (Disease Ontology:DOID:2394); cervical cancer (Disease Ontology:DOID:4362); type 2 diabetes mellitus (Disease Ontology:DOID:9352)", "pathway": " (dme:Dmel_CG10523); (R-DME-5205685); (R-DME-5689877); (R-DME-9646399); (R-DME-983168)", "pathway_count": 5, "publication_count": 35, "publication_id_list": "10731132;12537569;12537572;12642658;14646593;15073152;16002472;16672980;16672981;17123504;17456438;18230723;18443288;18799731;18957282;19048081;20194754;20483372;20496123;20869429;22396657;23509287;23650379;23770917;24192653;24898855;24901221;25474007;25565208;27906179;28435104;29497364;31714929;32047033;32138754", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as Paris, Marf, Opa1, Miro, pnut, Septin1, Tom20 and porin (PubMed:16002472, PubMed:17456438, PubMed:20194754, PubMed:23770917, PubMed:24192653, PubMed:24901221, PubMed:25474007, PubMed:27906179, PubMed:31714929, PubMed:32047033, PubMed:32138754). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates, depending on the context (PubMed:18957282, PubMed:23650379, PubMed:24901221, PubMed:25474007, PubMed:27906179, PubMed:31714929, PubMed:32047033). Protects against mitochondrial dysfunction during cellular stress, by acting downstream of Pink1, to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:12642658, PubMed:15073152, PubMed:16672980, PubMed:16672981, PubMed:17123504, PubMed:18230723, PubMed:18443288, PubMed:18799731, PubMed:18957282, PubMed:20194754, PubMed:20496123, PubMed:23509287, PubMed:24192653, PubMed:24901221, PubMed:25474007, PubMed:27906179, PubMed:29497364, PubMed:32047033). Depending on the severity of mitochondrial damage and/or dysfunction, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to regulating mitochondrial dynamics and eliminating severely damaged mitochondria via mitophagy (PubMed:12642658, PubMed:15073152, PubMed:16002472, PubMed:16672980, PubMed:16672981, PubMed:17123504, PubMed:18230723, PubMed:18443288, PubMed:18799731, PubMed:18957282, PubMed:20194754, PubMed:20496123, PubMed:23509287, PubMed:24192653, PubMed:24901221, PubMed:25474007, PubMed:27906179, PubMed:29497364, PubMed:32047033). Appears to be particularly important in maintaining the physiology and function of cells with high energy demands that are undergoing stress or altered metabolic environment, including spermatids, muscle cells and neurons such as the dopaminergic (DA) neurons (PubMed:12642658, PubMed:15073152, PubMed:16002472, PubMed:16672980, PubMed:17123504, PubMed:18799731, PubMed:20483372, PubMed:22396657, PubMed:24901221, PubMed:28435104, PubMed:29497364, PubMed:31714929). Activation and recruitment onto the outer membrane of damaged/dysfunctional mitochondria (OMM) requires Pink1-mediated phosphorylation of both park and ubiquitin (PubMed:18230723, PubMed:18799731, PubMed:18957282, PubMed:20194754, PubMed:22396657, PubMed:24901221, PubMed:25474007, PubMed:27906179). In depolarized mitochondria, mediates the decision between mitophagy or preventing apoptosis by inducing either the poly- or monoubiquitination of porin/VDAC; polyubiquitination of porin promotes mitophagy, while monoubiquitination of porin decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). When cellular stress results in irreversible mitochondrial damage, promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins (PubMed:16672980, PubMed:16672981, PubMed:18957282, PubMed:20194754, PubMed:23509287, PubMed:24192653, PubMed:25474007, PubMed:29497364). Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains following mitochondrial damage, leading to mitophagy (PubMed:23650379, PubMed:32047033). In developing tissues, inhibits JNK-mediated apoptosis by negatively regulating bsk transcription (PubMed:16002472, PubMed:20496123). The Pink1-park pathway also promotes fission and/or inhibits fusion of damaged mitochondria by mediating the ubiquitination and subsequent degradation of proteins involved in mitochondrial fusion/fission such as Marf, Opa1 and fzo (PubMed:17123504, PubMed:18230723, PubMed:18443288, PubMed:18799731, PubMed:20194754, PubMed:23650379, PubMed:24192653, PubMed:24901221, PubMed:29497364). This prevents the refusion of unhealthy mitochondria with the healthy mitochondrial network and/or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed:17123504, PubMed:18230723, PubMed:18443288, PubMed:18799731, PubMed:20194754, PubMed:23650379, PubMed:24192653, PubMed:24901221, PubMed:29497364). Regulates motility of damaged mitochondria by phosphorylating Miro which likely promotes its park-dependent degradation by the proteasome; in motor neurons, this inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria being eliminated in the soma (PubMed:22396657). The Pink1-park pathway is also involved in mitochondrial regeneration processes such as promoting mitochondrial biogenesis, activating localized mitochondrial repair, promoting selective turnover of mitochondrial proteins and initiating the mitochondrial import of endogenous proteins (PubMed:16672980, PubMed:20496123, PubMed:20869429, PubMed:23509287, PubMed:23650379, PubMed:24192653, PubMed:25565208, PubMed:29497364). Involved in mitochondrial biogenesis via the ubiquitination of transcriptional repressor Paris which leads to its subsequent proteasomal degradation and allows activation of the transcription factor srl (PubMed:23509287, PubMed:29497364, PubMed:32138754). Promotes localized mitochondrial repair by activating the translation of specific nuclear-encoded mitochondrial RNAs (nc-mtRNAs) on the mitochondrial surface, including several key electron transport chain component nc-mtRNAs (PubMed:23509287, PubMed:25565208)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 8, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 13, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86CZ3;Q86LE7;Q95TI4", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0030382 sperm mitochondrion organization;GO:1901526 positive regulation of mitophagy;GO:0006979 response to oxidative stress;GO:0007283 spermatogenesis;GO:0008344 adult locomotory behavior", "synthesized_glycan_count": 0, "hit_score": 3.6, "record_id": "Q7KTX7-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KU86-1", "uniprot_id": [ { "id": "URM1_DROME", "url": "https://www.uniprot.org/uniprot/Q7KU86", "type": "external" } ], "mass": 11486.0, "length": 101, "protein_name": "Ubiquitin-related modifier 1 homolog", "gene_name": "Urm1", "organism": "Fruit fly", "refseq_name": "Ubiquitin-related modifier 1", "refseq_ac": [ { "id": "NP_996018", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996018", "type": "external" } ], "gene_names_uniprotkb": "Urm1; CG33276", "gene_names_refseq": "CG33276; Dmel\\CG33276; Urm1; anon-AE003558.1", "protein_names_uniprotkb": "Ubiquitin-related modifier 1 homolog", "protein_names_refseq": "CG33276-PB; Ubiquitin-related modifier 1 ortholog; Ubiquitin-related modifier 1; Urm1-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33276)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;26715182;28953965", "class_list": "", "function": "Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln) (By similarity). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3 (By similarity). The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U (By similarity). Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as Prx2/Jafrac1, Ciao1, Eip71CD and GILT1 (PubMed:26715182, PubMed:28953965). The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates (By similarity). Plays a role in the regulation of JNK signaling in response to oxidative stress (PubMed:26715182)., [UniProtKB, HAMAP, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8E6X7;C1C595", "ec_number_list": [], "go_molecular_function": "GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0034227 tRNA thio-modification;GO:0046329 negative regulation of JNK cascade;GO:0002098 tRNA wobble uridine modification;GO:0032447 protein urmylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7KU86-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KUL4-1", "uniprot_id": [ { "id": "Q7KUL4_DROME", "url": "https://www.uniprot.org/uniprot/Q7KUL4", "type": "external" } ], "mass": 34491.0, "length": 320, "protein_name": "Intermediate neuroblasts defective", "gene_name": "ind", "organism": "Fruit fly", "refseq_name": "intermediate neuroblasts defective", "refseq_ac": [ { "id": "NP_996087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996087", "type": "external" } ], "gene_names_uniprotkb": "ind; CG11551; Dmel\\CG11551; Dmel_CG11551; Gsx; Ind", "gene_names_refseq": "CG11551; Dmel\\CG11551; Ind; ind/Gsx; ind", "protein_names_uniprotkb": "Intermediate neuroblasts defective", "protein_names_refseq": "CG11551-PB; ind-PB; intermediate nerve cord defective; intermediate neuroblast defective; intermediate neuroblasts defective", "tax_id": 7227, "disease": "pancreatic agenesis 1 (Disease Ontology:DOID:0061003); maturity-onset diabetes of the young type 4 (Disease Ontology:DOID:0111103); cerebral infarction (Disease Ontology:DOID:3526); hyperglycemia (Disease Ontology:DOID:4195); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG11551)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010629 negative regulation of gene expression;GO:0007417 central nervous system development;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7KUL4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KUT2-1", "uniprot_id": [ { "id": "LONM_DROME", "url": "https://www.uniprot.org/uniprot/Q7KUT2", "type": "external" } ], "mass": 115033.0, "length": 1024, "protein_name": "Lon protease homolog, mitochondrial", "gene_name": "Lon", "organism": "Fruit fly", "refseq_name": "Lon protease, isoform A", "refseq_ac": [ { "id": "NP_649133", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649133", "type": "external" } ], "gene_names_uniprotkb": "Lon; CG8798", "gene_names_refseq": "CG8798; Dmel\\CG8798; LONP1; LONP; LON; Lon; anon-WO0118547.350; dLon P1", "protein_names_uniprotkb": "Lon protease homolog, mitochondrial; 3.4.21.53", "protein_names_refseq": "CG8798-PA; Lon protease, isoform A; Lon-PA", "tax_id": 7227, "disease": "CODAS syndrome (Disease Ontology:DOID:0111274); brain ischemia (Disease Ontology:DOID:2316); ischemia (Disease Ontology:DOID:326)", "pathway": " (dme:Dmel_CG8798); (R-DME-9837999)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537572;20930118", "class_list": "", "function": "ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. Regulates mitochondrial DNA (mtDNA) copy number and transcription by stabilizing the mitochondrial TFAM:mtDNA ratio via selective degradation of TFAM., [UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VW20", "ec_number_list": [ { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.1.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.40", "type": "external" }, { "id": "1.1.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38", "type": "external" }, { "id": "1.1.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.39", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.51", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "2.7.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.8.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.3.5", "type": "external" }, { "id": "2.3.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.-.-", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.16", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0017171 serine hydrolase activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005777 peroxisome", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0045732 positive regulation of protein catabolic process;GO:0007005 mitochondrion organization;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins;GO:0051131 chaperone-mediated protein complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7KUT2-1", "record_type": "protein", "filter_code": "0000000.0100111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KVA1-1", "uniprot_id": [ { "id": "XYLT_DROME", "url": "https://www.uniprot.org/uniprot/Q7KVA1", "type": "external" } ], "mass": 99098.0, "length": 876, "protein_name": "Xylosyltransferase Oxt", "gene_name": "Oxt", "organism": "Fruit fly", "refseq_name": "peptide O-xylosyltransferase", "refseq_ac": [ { "id": "NP_647705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647705", "type": "external" } ], "gene_names_uniprotkb": "Oxt; CG17771; CG17772; CG32300", "gene_names_refseq": "CG17771; CG17772; CG32300; Dmel\\CG32300; OXT; Oxt; anon-i2; dOXT; dXylT; oxt", "protein_names_uniprotkb": "Xylosyltransferase Oxt; 2.4.2.26; Imaginal disk type I; Peptide O-xylosyltransferase", "protein_names_refseq": "CG32300-PB; O-xylosyltransferase; Peptide-O-xylosyl-transferase; Peptide-o-xylosyltransferase; drosophila peptide O-xylosyltransferase; oxt-PB; peptide O-xylosyltransferase", "tax_id": 7227, "disease": "Desbuquois dysplasia (Disease Ontology:DOID:0060462); polycystic kidney disease (Disease Ontology:DOID:0080322); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); kidney disease (Disease Ontology:DOID:557); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dme:Dmel_CG32300); (R-DME-1971475)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;11929872;12537569;12537572", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the first step in biosynthesis of glycosaminoglycan (PubMed:11929872). Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein (PubMed:11929872)., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q24116;Q9W034;Q9W035", "ec_number_list": [ { "id": "2.4.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.26", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030158 protein xylosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0120532 glycosaminoglycan-protein linkage region biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7KVA1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KVQ0-1", "uniprot_id": [ { "id": "GAR1_DROME", "url": "https://www.uniprot.org/uniprot/Q7KVQ0", "type": "external" } ], "mass": 22665.0, "length": 237, "protein_name": "H/ACA ribonucleoprotein complex subunit 1", "gene_name": "Gar1", "organism": "Fruit fly", "refseq_name": "Gar1 ribonucleoprotein", "refseq_ac": [ { "id": "NP_477043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477043", "type": "external" } ], "gene_names_uniprotkb": "Gar1; CG4038", "gene_names_refseq": "CG4038-PA; CG4038; Dmel\\CG4038; GAR1; GCR 101; GCR101 SnRNP; GCR101; Gar1; Pen101; anon-Pen101; dGAR1", "protein_names_uniprotkb": "H/ACA ribonucleoprotein complex subunit 1; GCR 101 snRNP; Nucleolar protein family A member 1; Ribonucleoprotein Gar1", "protein_names_refseq": "CG4038-PA; Gar1 ribonucleoprotein; Gar1-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4038)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;37343092", "class_list": "", "function": "Component of the box H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (Probable). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (Probable). Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (Probable). Required for ribosome biogenesis (By similarity). H/ACA snoRNP complex-dependent ribosome biogenesis is important in female germline cell differentiation during oogenesis (PubMed:37343092)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24345;Q86R95;Q9W2L8", "ec_number_list": [], "go_molecular_function": "GO:0034513 box H/ACA snoRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0031429 box H/ACA snoRNP complex;GO:0005732 sno(s)RNA-containing ribonucleoprotein complex", "go_biological_process": "GO:0031118 rRNA pseudouridine synthesis;GO:0000454 snoRNA guided rRNA pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7KVQ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KVR8-1", "uniprot_id": [ { "id": "Q7KVR8_DROME", "url": "https://www.uniprot.org/uniprot/Q7KVR8", "type": "external" } ], "mass": 106926.0, "length": 982, "protein_name": "AP-1 complex subunit gamma", "gene_name": "AP-1gamma", "organism": "Fruit fly", "refseq_name": "adaptor protein complex 1, gamma subunit, isoform D", "refseq_ac": [ { "id": "NP_788891", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788891", "type": "external" } ], "gene_names_uniprotkb": "AP-1gamma; AP-1 gamma; AP-1-gamma; AP-1[gamma]; AP-1g; AP-1; AP1gamma1; AP1gamma; Ap-1; CG9113; Dmel\\CG9113; Dmel_CG9113; apl4; cg9113; dgamma; gamma-Ada; gamma", "gene_names_refseq": "AP-1 gamma; AP-1[gamma]; AP-1gamma; AP-1g; AP-1; AP1gamma1; AP1gamma; Ap-1; CG9113; Dmel\\CG9113; apl4; cg9113; dgamma; gamma-Ada; gamma", "protein_names_uniprotkb": "AP-1 complex subunit gamma", "protein_names_refseq": "AP-1gamma-PD; CG9113-PD; adaptor protein complex 1, gamma subunit, isoform D; gamma subunit of AP-1 clathrin; gamma-adaptin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9113); (R-DME-432720); (R-DME-432722)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0030141 secretory granule;GO:0055037 recycling endosome;GO:0030136 clathrin-coated vesicle;GO:0005802 trans-Golgi network;GO:0030121 AP-1 adaptor complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0033363 secretory granule organization;GO:0035652 clathrin-coated vesicle cargo loading;GO:0016192 vesicle-mediated transport;GO:0006896 Golgi to vacuole transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q7KVR8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7KVS9-1", "uniprot_id": [ { "id": "TRF41_DROME", "url": "https://www.uniprot.org/uniprot/Q7KVS9", "type": "external" } ], "mass": 108718.0, "length": 1001, "protein_name": "Non-canonical poly(A) RNA polymerase protein Trf4-1", "gene_name": "Trf4-1", "organism": "Fruit fly", "refseq_name": "topoisomerase related function 4-1, isoform F", "refseq_ac": [ { "id": "NP_001096913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096913", "type": "external" } ], "gene_names_uniprotkb": "Trf4-1; CG11265", "gene_names_refseq": "AAF46390; CG11265; DmTRF4-1; Dmel\\CG11265; Trf4-1; Trf4; dTrf4-1", "protein_names_uniprotkb": "Non-canonical poly(A) RNA polymerase protein Trf4-1; 2.7.7.19; Topoisomerase 1-related protein 4-1", "protein_names_refseq": "CG11265-PF; Trf4-1-PF; topoisomerase related function 4-1, isoform F", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11265)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;18765642;26786835", "class_list": "", "function": "Involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information (PubMed:18765642, PubMed:26786835). Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates (PubMed:26786835). Polyadenylates RNA processing and degradation intermediates of snRNAs and mRNAs (PubMed:18765642, PubMed:26786835)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A8JV36", "ec_number_list": [ { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016853 isomerase activity;GO:1990817 poly(A) RNA polymerase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0031499 TRAMP complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0031123 RNA 3'-end processing;GO:0043634 polyadenylation-dependent ncRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q7KVS9-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7PLS8-1", "uniprot_id": [ { "id": "INT3_DROME", "url": "https://www.uniprot.org/uniprot/Q7PLS8", "type": "external" } ], "mass": 123951.0, "length": 1068, "protein_name": "Integrator complex subunit 3", "gene_name": "IntS3", "organism": "Fruit fly", "refseq_name": "integrator 3", "refseq_ac": [ { "id": "NP_001036437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036437", "type": "external" } ], "gene_names_uniprotkb": "IntS3; CG17665", "gene_names_refseq": "CG17665; Dmel\\CG17665; IR23; Int3; IntS3; NC19; NC28; l(2)IR23; l(2)NC19; l(2)NC28; l(2Rh)IR23", "protein_names_uniprotkb": "Integrator complex subunit 3; SOSS complex subunit A homolog", "protein_names_refseq": "CG17665-PA; IntS3-PA; integrator 3; lethal (2) IR23; lethal (2) NC19; lethal (2) NC28", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17665); (R-DME-6807505)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537569;12537572;18327897;21078872;23097424;31530651;32966759;37995689;39032490;40245499", "class_list": "", "function": "Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:21078872, PubMed:23097424, PubMed:32966759). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity (PubMed:32966759). The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q7PLS7;Q8IH20", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0032039 integrator complex;GO:0160232 INTAC complex", "go_biological_process": "GO:0016180 snRNA processing;GO:0160240 RNA polymerase II transcription initiation surveillance", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q7PLS8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7YU24-1", "uniprot_id": [ { "id": "MARF_DROME", "url": "https://www.uniprot.org/uniprot/Q7YU24", "type": "external" } ], "mass": 91372.0, "length": 810, "protein_name": "Transmembrane GTPase Marf", "gene_name": "Marf", "organism": "Fruit fly", "refseq_name": "mitochondrial assembly regulatory factor, isoform D", "refseq_ac": [ { "id": "NP_572320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572320", "type": "external" } ], "gene_names_uniprotkb": "Marf; CG3869; dmfn", "gene_names_refseq": "CG3869; CG38869; Dmel\\CG3869; MARF; MFN2; MFN; Marf-1; Marf; Mfn-2; Mfn2; Mfn; anon-WO0125274.3; dMARF; dMFN; dMarf; dMfn2; dMfn; dmfn; marf; mfn2; mfn", "protein_names_uniprotkb": "Transmembrane GTPase Marf; 3.6.5.-; Mitochondrial assembly regulatory factor; Mitofusin", "protein_names_refseq": "CG3869-PD; Marf-PD; drosophila mitofusin; mitochondria assembly regulatory factor; mitochondrial assembly regulatory factor, isoform D; mitochondrial assembly regulatory factor; mitochondrial assembly; mitofusin/MARF; mitofusin", "tax_id": 7227, "disease": "Charcot-Marie-Tooth disease type 2 (Disease Ontology:DOID:0050539); Charcot-Marie-Tooth disease type 6 (Disease Ontology:DOID:0080068); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Charcot-Marie-Tooth disease type 2A2A (Disease Ontology:DOID:0110155); Charcot-Marie-Tooth disease type 2A2B (Disease Ontology:DOID:0111557); Charcot-Marie-Tooth disease (Disease Ontology:DOID:10595); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); adult respiratory distress syndrome (Disease Ontology:DOID:11394); prediabetes syndrome (Disease Ontology:DOID:11716); carotid stenosis (Disease Ontology:DOID:13001); dental fluorosis (Disease Ontology:DOID:13711); multiple symmetric lipomatosis (Disease Ontology:DOID:14116); primary pulmonary hypertension (Disease Ontology:DOID:14557); depressive disorder (Disease Ontology:DOID:1596); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); acute kidney failure (Disease Ontology:DOID:3021); pulmonary fibrosis (Disease Ontology:DOID:3770); rhinitis (Disease Ontology:DOID:4483); myocardial infarction (Disease Ontology:DOID:5844); migraine (Disease Ontology:DOID:6364); pulmonary hypertension (Disease Ontology:DOID:6432); chronic kidney disease (Disease Ontology:DOID:784); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG3869); (R-DME-5205685); (R-DME-9013419); (R-DME-983231)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10731132;12128227;12537569;12537572;12598526;18327897;18799731;20194754;20869429;22396657;24192653;24898855;25594180;26214738", "class_list": "", "function": "Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:18799731, PubMed:20869429, PubMed:22396657, PubMed:24192653, PubMed:26214738). Mitochondrial fusion is the physical merging of mitochondria that gives rise to mitochondrial networks, and this process is counterbalanced by mitochondrial fission which fragments networks (PubMed:20869429, PubMed:22396657, PubMed:24192653). Promotes, but is not required for park recruitment to dysfunctional mitochondria (PubMed:20194754)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 28, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0KHV7;Q86DQ3;Q8T3J4;Q9W3Z9", "ec_number_list": [ { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005740 mitochondrial envelope;GO:0005741 mitochondrial outer membrane;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0010636 positive regulation of mitochondrial fusion;GO:0090140 regulation of mitochondrial fission;GO:0008344 adult locomotory behavior;GO:0007005 mitochondrion organization;GO:0008053 mitochondrial fusion", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q7YU24-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7YZA2-1", "uniprot_id": [ { "id": "Y7065_DROME", "url": "https://www.uniprot.org/uniprot/Q7YZA2", "type": "external" } ], "mass": 136767.0, "length": 1231, "protein_name": "Uncharacterized protein CG7065", "gene_name": "CG7065", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_572529", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572529", "type": "external" } ], "gene_names_uniprotkb": "CG7065", "gene_names_refseq": "CG7065; Dmel\\CG7065", "protein_names_uniprotkb": "Uncharacterized protein CG7065", "protein_names_refseq": "CG7065-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7065)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;17372656;18327897", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8T031;Q9W386", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0016592 mediator complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q7YZA2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q86B47-1", "uniprot_id": [ { "id": "Y8611_DROME", "url": "https://www.uniprot.org/uniprot/Q86B47", "type": "external" } ], "mass": 107968.0, "length": 975, "protein_name": "Probable ATP-dependent RNA helicase CG8611", "gene_name": "DmRH11", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": [ { "id": "NP_573214", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573214", "type": "external" } ], "gene_names_uniprotkb": "DmRH11; BcDNA:GH02833; CG8611; Dmel\\CG8611; Dmel_CG8611; cg8611", "gene_names_refseq": "BcDNA:GH02833; CG8611; DmRH11; Dmel\\CG8611; cg8611", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase CG8611; 3.6.4.13", "protein_names_refseq": "CG8611-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8611)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;10731138;12537568;12537572;12537573;12537574;16110336;17372656;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Probable ATP-dependent RNA helicase., [UniProtKB]; RNA helicase., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9VX53;Q9Y159", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "5.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q86B47-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q86BJ3-1", "uniprot_id": [ { "id": "UST_DROME", "url": "https://www.uniprot.org/uniprot/Q86BJ3", "type": "external" } ], "mass": 60260.0, "length": 514, "protein_name": "Uronyl 2-sulfotransferase homolog pip", "gene_name": "pip", "organism": "Fruit fly", "refseq_name": "pipe, isoform A", "refseq_ac": [ { "id": "NP_524158", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524158", "type": "external" } ], "gene_names_uniprotkb": "pip; CG9614", "gene_names_refseq": "CG9614; Dmel\\CG9614; PIP2; Pipe; l(3)76BDp; pipe-ST2; pip", "protein_names_uniprotkb": "Uronyl 2-sulfotransferase homolog pip; 2.8.2.-; Heparan sulfate 2-O-sulfotransferase pipe; Protein pipe; UST", "protein_names_refseq": "CG9614-PA; pip-PA; pipe, isoform A; pipe", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9614); (R-DME-2022870); (R-DME-2022923)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10731132;11076773;11169845;12050143;12537572;12941941;15252019;16566925;17227754;19540119;20605458;9568717;9827800", "class_list": "", "function": "Lacks 2-O-sulfotransferase activity towards CDSNS heparin, chondroitin, and chondroitin sulfate A, B (dermatan sulfate), and C., [UniProtKB, PubMed]; Probably required redundantly with isoform A for dorsoventral axis patterning in embryos., [UniProtKB, PubMed]; Probably required redundantly with isoform H for dorsoventral axis patterning in embryos (PubMed:11169845). Lacks 2-O-sulfotransferase activity towards completely desulfated N-sulfated (CDSNS) heparin, chondroitin, and chondroitin sulfate A, B (dermatan sulfate), and C (PubMed:17227754). Sulfates several components of the eggshell vitelline membrane, including Vml, Vm26Aa, Vm32E and psd/palisade/Fcp26Aa (PubMed:19540119)., [UniProtKB, PubMed, PubMed, PubMed]; Sulfotransferase involved in dorsoventral axis patterning in early embryos (PubMed:9568717, PubMed:9827800). Required for the ventral activation of ea/easter by the protease snk in the perivitelline space between the embryonic membrane and the eggshell; activation of ea requires both activation of the ndl-gd-snk protease cascade and sulfation of a vitelline membrane component by pip (PubMed:16566925, PubMed:20605458, PubMed:9827800). Probably acts by mediating the sulfation of some glycoprotein or glycosaminoglycan stably deposited in the vitelline membrane, whose ventrally localized modification leads to spatially restricted activation of the protease cascade resulting in localized activation of the spz Toll receptor ligand by ea (Probable)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "B9EQT7;E1JI38;E4NKL9;E8NH03;F2FB47;O96662;Q7KNQ1;Q86BJ2;Q86BJ4;Q86BJ5;Q86BJ6;Q86BJ7;Q86BJ8;Q86BJ9;Q86BK0;Q8IQU0;Q968U2;Q9VVY5", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0061133 endopeptidase activator activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005794 Golgi apparatus;GO:0005694 chromosome", "go_biological_process": "GO:0040014 regulation of multicellular organism growth;GO:0009880 embryonic pattern specification;GO:0009950 dorsal/ventral axis specification;GO:0160032 Toll receptor ligand protein activation cascade", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q86BJ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q86LG1-1", "uniprot_id": [ { "id": "PPK28_DROME", "url": "https://www.uniprot.org/uniprot/Q86LG1", "type": "external" } ], "mass": 69225.0, "length": 606, "protein_name": "Pickpocket protein 28", "gene_name": "ppk28", "organism": "Fruit fly", "refseq_name": "pickpocket 28", "refseq_ac": [ { "id": "NP_573169", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573169", "type": "external" } ], "gene_names_uniprotkb": "ppk28; CG4805", "gene_names_refseq": "CG4805; Dmel\\CG4805; PPK-28; PPK28; Ppk28; ppk-28; ppk28", "protein_names_uniprotkb": "Pickpocket protein 28; PPK28", "protein_names_refseq": "CG4805-PA; pickpocket 28; ppk28-PA", "tax_id": 7227, "disease": "Liddle syndrome (Disease Ontology:DOID:0050477); autosomal recessive pseudohypoaldosteronism type 1 (Disease Ontology:DOID:0060854); nephrotic syndrome (Disease Ontology:DOID:1184); neurodegenerative disease (Disease Ontology:DOID:1289); cystic fibrosis (Disease Ontology:DOID:1485); ischemia (Disease Ontology:DOID:326); congenital diaphragmatic hernia (Disease Ontology:DOID:3827)", "pathway": " (dme:Dmel_CG4805)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537572;12571352;12848938;20364123;20445050", "class_list": "", "function": "Osmosensitive ion channel that mediates the cellular and behavioral response to water. Plays an essential role in gustatory water reception. Part of a complex that plays a role in tracheal liquid clearance. Probable role in sodium transport., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86LG0;Q9VXA6", "ec_number_list": [], "go_molecular_function": "GO:0005272 sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0042756 drinking behavior;GO:0035725 sodium ion transmembrane transport;GO:0006814 sodium ion transport;GO:0009415 response to water;GO:0035002 liquid clearance, open tracheal system", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q86LG1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q86PC9-1", "uniprot_id": [ { "id": "TULP_DROME", "url": "https://www.uniprot.org/uniprot/Q86PC9", "type": "external" } ], "mass": 51281.0, "length": 460, "protein_name": "Protein king tubby", "gene_name": "ktub", "organism": "Fruit fly", "refseq_name": "king tubby, isoform C", "refseq_ac": [ { "id": "NP_611549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611549", "type": "external" } ], "gene_names_uniprotkb": "ktub; CG9398; Tulp", "gene_names_refseq": "87D3S; CG9398; D-tulp; Dmel\\CG9398; Dtulp; ESTS:87D3S; King-Tubby; King-tubby; TULP; Tulp; dTULP; dTulp; king-tubby; ktub; tulp", "protein_names_uniprotkb": "Protein king tubby", "protein_names_refseq": "CG9398-PC; Tubby-like; dTULP; king tubby, isoform C; king tubby; king-tubby; ktub-PC; tubby-like protein", "tax_id": 7227, "disease": "ciliopathy (Disease Ontology:DOID:0060340); polycystic kidney disease (Disease Ontology:DOID:0080322); Leber congenital amaurosis 15 (Disease Ontology:DOID:0110189); retinitis pigmentosa 14 (Disease Ontology:DOID:0110381); retinitis pigmentosa (Disease Ontology:DOID:10584); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG9398)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10731132;12204260;12537569;12537572;18327897;23228091;23355467;24068974;26723017", "class_list": "", "function": "Functions in regulating protein trafficking, retinal maintenance and lipid storage (PubMed:23228091, PubMed:23355467, PubMed:24068974, PubMed:26723017). Protects photoreceptor cells R1 to R6 against light-induced retinal degeneration by stimulating norpA-mediated endocytosis of the rhodopsin ninaE (Rh1) (PubMed:23228091). In the auditory receptor neurons, functions as a cilia trafficking regulator of various transient receptor potential (TRP) channel components including iav and nompC (PubMed:24068974, PubMed:26723017). Likely to deliver pre-ciliary vesicles containing membrane proteins such as iav and nompC to the intraflagellar transport complex (IFT) at the cilia base (PubMed:24068974, PubMed:26723017). Plays a role in the inhibition of fat storage (PubMed:23355467)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MUB4;Q9W2L5", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005929 cilium;GO:0043025 neuronal cell body;GO:0060170 ciliary membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0042593 glucose homeostasis;GO:0007605 sensory perception of sound;GO:0070328 triglyceride homeostasis;GO:0009744 response to sucrose", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q86PC9-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8I9B4-1", "uniprot_id": [ { "id": "MT4_DROME", "url": "https://www.uniprot.org/uniprot/Q8I9B4", "type": "external" } ], "mass": 4545.0, "length": 44, "protein_name": "Metallothionein-4", "gene_name": "MtnD", "organism": "Fruit fly", "refseq_name": "metallothionein D", "refseq_ac": [ { "id": "NP_788695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788695", "type": "external" } ], "gene_names_uniprotkb": "MtnD; CG33192", "gene_names_refseq": "CG33192; Dmel\\CG33192; MTND; MT; MtnD; mtnD", "protein_names_uniprotkb": "Metallothionein-4; MT-4; Metallothionein D", "protein_names_refseq": "CG33192-PB; MtnD-PB; metallothionein D; metallothionein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33192)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12505988;12537572", "class_list": "", "function": "This protein binds cations of several transition elements. Thought to be involved in metal ion homeostasis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1WW94;Q86B88", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0046688 response to copper ion;GO:0010038 response to metal ion;GO:0140961 cellular detoxification of metal ion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8I9B4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IA41-1", "uniprot_id": [ { "id": "GLT11_DROME", "url": "https://www.uniprot.org/uniprot/Q8IA41", "type": "external" } ], "mass": 64539.0, "length": 557, "protein_name": "Putative inactive polypeptide N-acetylgalactosaminyltransferase 11", "gene_name": "pgant11", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_648799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648799", "type": "external" } ], "gene_names_uniprotkb": "pgant11; CG7579", "gene_names_refseq": "CG7579; Dmel\\CG7579; dppGalNAcT12", "protein_names_uniprotkb": "Putative inactive polypeptide N-acetylgalactosaminyltransferase 11; Inactive UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11; Inactive protein-UDP acetylgalactosaminyltransferase 11; pp-GaNTase 11", "protein_names_refseq": "CG7579-PA; uncharacterized protein", "tax_id": 7227, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (dme:Dmel_CG7579); (R-DME-913709)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;11925450;12537572", "class_list": "", "function": "Probable inactive glycosyltransferase., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9VUT5", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8IA41-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IA44-1", "uniprot_id": [ { "id": "GLT12_DROME", "url": "https://www.uniprot.org/uniprot/Q8IA44", "type": "external" } ], "mass": 65108.0, "length": 563, "protein_name": "Putative inactive polypeptide N-acetylgalactosaminyltransferase 12", "gene_name": "pgant12", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_996098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996098", "type": "external" } ], "gene_names_uniprotkb": "pgant12; CG7304", "gene_names_refseq": "CG7304; Dmel\\CG7304; dppGalNAcT11", "protein_names_uniprotkb": "Putative inactive polypeptide N-acetylgalactosaminyltransferase 12; Inactive UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12; Inactive protein-UDP acetylgalactosaminyltransferase 12; pp-GaNTase 12", "protein_names_refseq": "CG7304-PB; uncharacterized protein", "tax_id": 7227, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (dme:Dmel_CG7304); (R-DME-913709)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;11925450;12537572", "class_list": "", "function": "Probable inactive glycosyltransferase., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q9VUT4", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine;GO:0007618 mating", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8IA44-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IH00-1", "uniprot_id": [ { "id": "NOL6_DROME", "url": "https://www.uniprot.org/uniprot/Q8IH00", "type": "external" } ], "mass": 136385.0, "length": 1193, "protein_name": "Nucleolar protein 6", "gene_name": "Mat89Ba", "organism": "Fruit fly", "refseq_name": "maternal transcript 89Ba", "refseq_ac": [ { "id": "NP_650530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650530", "type": "external" } ], "gene_names_uniprotkb": "Mat89Ba; CG12785", "gene_names_refseq": "CG12785; Dmel\\CG12785; Mat89Ba", "protein_names_uniprotkb": "Nucleolar protein 6; Maternal transcript 89Ba", "protein_names_refseq": "CG12785-PA; Mat89Ba-PA; maternal transcript 89Ba", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12785); (R-DME-6791226)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;18327897;9799434", "class_list": "", "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VEX3", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005730 nucleolus;GO:0032040 small-subunit processome;GO:0032545 CURI complex;GO:0034456 UTP-C complex", "go_biological_process": "GO:0006409 tRNA export from nucleus;GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8IH00-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IMM9-1", "uniprot_id": [ { "id": "NENYA_DROME", "url": "https://www.uniprot.org/uniprot/Q8IMM9", "type": "external" } ], "mass": 25980.0, "length": 219, "protein_name": "RING finger protein nenya", "gene_name": "nenya", "organism": "Fruit fly", "refseq_name": "nenya", "refseq_ac": [ { "id": "NP_733236", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_733236", "type": "external" } ], "gene_names_uniprotkb": "nenya; CG31053", "gene_names_refseq": "CG31053; Dmel\\CG31053; Nenya; nenya", "protein_names_uniprotkb": "RING finger protein nenya", "protein_names_refseq": "CG31053-PA; nenya-PA; nenya", "tax_id": 7227, "disease": "spermatogenic failure 62 (Disease Ontology:DOID:0112351)", "pathway": " (dme:Dmel_CG31053)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;30615609", "class_list": "", "function": "Required for the formation of DNA double-strand breaks together with narya and vilya during the meiotic recombination process (PubMed:30615609). Plays a redundant role with narya in chromosome segregation during female meiosis (PubMed:30615609)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019789 SUMO transferase activity", "go_cellular_component": "GO:0005694 chromosome;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0007129 homologous chromosome pairing at meiosis;GO:0007131 reciprocal meiotic recombination;GO:1903343 positive regulation of meiotic DNA double-strand break formation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8IMM9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IMN6-1", "uniprot_id": [ { "id": "GR98C_DROME", "url": "https://www.uniprot.org/uniprot/Q8IMN6", "type": "external" } ], "mass": 47392.0, "length": 408, "protein_name": "Putative gustatory receptor 98c", "gene_name": "Gr98c", "organism": "Fruit fly", "refseq_name": "gustatory receptor 98c", "refseq_ac": [ { "id": "NP_524531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524531", "type": "external" } ], "gene_names_uniprotkb": "Gr98c; 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CG31280; GR94E.1", "gene_names_refseq": "94E.1; CG31280; Dmel\\CG31280; GR94E.1; GR94a; Gr94E1; Gr94a", "protein_names_uniprotkb": "Putative gustatory receptor 94a", "protein_names_refseq": "CG31280-PA; Gr94a-PA; gustatory receptor 94E.1; gustatory receptor 94a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31280)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10710312;10731132;12537572;22031876", "class_list": "", "function": "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007165 signal transduction;GO:0034220 monoatomic ion transmembrane transport;GO:0050909 sensory perception of taste", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8IMZ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IN05-1", "uniprot_id": [ { "id": "Q8IN05_DROME", "url": "https://www.uniprot.org/uniprot/Q8IN05", "type": "external" } ], "mass": 158013.0, "length": 1415, "protein_name": "Liquid facets-Related, isoform D", "gene_name": "lqfR", "organism": "Fruit fly", "refseq_name": "liquid facets-Related, isoform D", "refseq_ac": [ { "id": "NP_732736", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_732736", "type": "external" } ], "gene_names_uniprotkb": "lqfR; CG13853; CG13854; CG31170; CG31285; CG42250; Dmel\\CG42250; Dmel_CG42250; Epsin; LqfR; Lqfr; Tel2; XII-10; dTel2; epsin-like; epsin02; epsinR; epsin; l(3)03685; l(3)A9; l(3)SG62; l(3)XII-10; l(3)dsl-9; l(3)dsl9", "gene_names_refseq": "CG13853; CG13854; CG31170; CG31285; CG42250; Dmel\\CG42250; Epsin; LqfR; Lqfr; Tel2; XII-10; dTel2; epsin-like; epsin02; epsinR; epsin; l(3)03685; l(3)A9; l(3)SG62; l(3)XII-10; l(3)dsl-9; l(3)dsl9; lqfR", "protein_names_uniprotkb": "Liquid facets-Related, isoform D", "protein_names_refseq": "CG42250-PD; EpsinR; epsin-2; epsin-like; lethal (3) SG62; liquid facet related; liquid facets related; liquid facets-Related, isoform D; liquid facets-Related; liquid-facets related; lqfR-PD", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG42250); (R-DME-432722)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0030276 clathrin binding", "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome", "go_biological_process": "GO:0006897 endocytosis;GO:0048477 oogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8IN05-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IN42-1", "uniprot_id": [ { "id": "TOTZ_DROME", "url": "https://www.uniprot.org/uniprot/Q8IN42", "type": "external" } ], "mass": 16179.0, "length": 147, "protein_name": "Protein Turandot Z", "gene_name": "TotZ", "organism": "Fruit fly", "refseq_name": "turandot Z", "refseq_ac": [ { "id": "NP_536782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536782", "type": "external" } ], "gene_names_uniprotkb": "TotZ; CG31507", "gene_names_refseq": "CG31507; Dmel\\CG31507; TotZ; Totz; tot", "protein_names_uniprotkb": "Protein Turandot Z", "protein_names_refseq": "CG31507-PA; TotZ-PA; turandot Z", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31507)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;11409894;12537572", "class_list": "", "function": "A humoral factor that may play a role in stress tolerance., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q962D5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0045087 innate immune response;GO:0034605 cellular response to heat;GO:0009617 response to bacterium;GO:0034599 cellular response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8IN42-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IN44-1", "uniprot_id": [ { "id": "TOTA_DROME", "url": "https://www.uniprot.org/uniprot/Q8IN44", "type": "external" } ], "mass": 14220.0, "length": 129, "protein_name": "Protein Turandot A", "gene_name": "TotA", "organism": "Fruit fly", "refseq_name": "turandot A", "refseq_ac": [ { "id": "NP_536778", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536778", "type": "external" } ], "gene_names_uniprotkb": "TotA; CG31509", "gene_names_refseq": "CG31509; DIM 31; Dmel\\CG31509; Tot A; Tot-A; TotA; Tot; Turt; totA; tot", "protein_names_uniprotkb": "Protein Turandot A", "protein_names_refseq": "CG31509-PA; Stress-inducible humoral factor turandot A; TotA-PA; Turandot-A; turandot A; turandot", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31509)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;11369236;11409894;12537572;12967563;16611243", "class_list": "", "function": "A humoral factor that plays a role in stress tolerance; gives increased resistance to the lethal effects of bacterial challenge and stress. Regulated by the JAK/STAT pathway and NF-KB-like Relish pathway in the fat body, upd3 in the hemocytes and Mekk1 in response to septic injury and consequent immune response., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q95NS3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0009409 response to cold;GO:0045087 innate immune response;GO:0034605 cellular response to heat;GO:0009617 response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8IN44-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IN78-1", "uniprot_id": [ { "id": "TIM22_DROME", "url": "https://www.uniprot.org/uniprot/Q8IN78", "type": "external" } ], "mass": 21032.0, "length": 195, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim22", "gene_name": "Tim22", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_732364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_732364", "type": "external" } ], "gene_names_uniprotkb": "Tim22; CG31229", "gene_names_refseq": "CG31229; Dmel\\CG31229", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim22", "protein_names_refseq": "CG31229-PA; uncharacterized protein", "tax_id": 7227, "disease": "combined oxidative phosphorylation deficiency 43 (Disease Ontology:DOID:0112116); mitochondrial myopathy (Disease Ontology:DOID:699)", "pathway": " (dme:Dmel_CG31229); (R-DME-1268020)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V6C7", "ec_number_list": [], "go_molecular_function": "GO:0008320 protein transmembrane transporter activity;GO:0030943 mitochondrion targeting sequence binding", "go_cellular_component": "GO:0042721 TIM22 mitochondrial import inner membrane insertion complex", "go_biological_process": "GO:0045039 protein insertion into mitochondrial inner membrane", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8IN78-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8INC0-1", "uniprot_id": [ { "id": "Q8INC0_DROME", "url": "https://www.uniprot.org/uniprot/Q8INC0", "type": "external" } ], "mass": 60291.0, "length": 552, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG32855", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_732112", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_732112", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG32855; CG32855; Dmel_CG32855", "gene_names_refseq": "CG32855; Dmel\\CG32855", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG32855-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32855)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8INC0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IND4-1", "uniprot_id": [ { "id": "Q8IND4_DROME", "url": "https://www.uniprot.org/uniprot/Q8IND4", "type": "external" } ], "mass": 26616.0, "length": 225, "protein_name": "Uncharacterized protein", "gene_name": "NEST:bs25d10", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_732055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_732055", "type": "external" } ], "gene_names_uniprotkb": "NEST:bs25d10; BcDNA:AT21457; CG31294; Dmel\\CG31294; Dmel_CG31294; NEST:bs15e12", "gene_names_refseq": "BcDNA:AT21457; CG31294; Dmel\\CG31294; NEST:bs15e12; NEST:bs25d10", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG31294-PA; uncharacterized protein", "tax_id": 7227, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); primary ciliary dyskinesia 45 (Disease Ontology:DOID:0111857); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); drug dependence (Disease Ontology:DOID:9974); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dme:Dmel_CG31294)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8IND4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8INI8-1", "uniprot_id": [ { "id": "HSP72_DROME", "url": "https://www.uniprot.org/uniprot/Q8INI8", "type": "external" } ], "mass": 70181.0, "length": 641, "protein_name": "Major heat shock 70 kDa protein Ba", "gene_name": "Hsp70Ba", "organism": "Fruit fly", "refseq_name": "heat shock protein 70 Ba", "refseq_ac": [ { "id": "NP_731716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_731716", "type": "external" } ], "gene_names_uniprotkb": "Hsp70Ba; CG31449", "gene_names_refseq": "CG31449; Dm-hsp70; Dmel\\CG31449; HSP70cA3; HSP70; Hsp 70; Hsp-70; Hsp70(87C); Hsp70Ba; Hsp70B; Hsp70; dHsp70; dhsp70; hsp-70; hsp70 87C; hsp70 Ba; hsp70Ba; hsp70B; hsp70ba; hsp70b; hsp70", "protein_names_uniprotkb": "Major heat shock 70 kDa protein Ba; HSP70-87C1; Heat shock protein 70Ba", "protein_names_refseq": "70 kDa heat shock protein, cytosolic A 3; 87C locus; CG31449-PA; Heat-shock-protein-70Ba; Hsp70Ba-PA; heat shock 70; heat shock protein 70 Ba; heat shock protein 70BA; heat-shock protein 70; hsp70 87C; protein 70", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31359); (dme:Dmel_CG31449); (dme:Dmel_CG6489)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10731132;11441029;11493638;11687637;11965431;12537572;18344983", "class_list": "", "function": "Stress-response chaperone protein that prevents toxic aggregation of proteins., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "C7LA76;P02824;Q95NK0;Q95W08;Q9BIS1;Q9BIS3;Q9BIS4;Q9I7J6", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0001666 response to hypoxia;GO:0009408 response to heat;GO:0042026 protein refolding;GO:0006986 response to unfolded protein;GO:0035080 heat shock-mediated polytene chromosome puffing", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8INI8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8INZ1-1", "uniprot_id": [ { "id": "GL36A_DROME", "url": "https://www.uniprot.org/uniprot/Q8INZ1", "type": "external" } ], "mass": 48502.0, "length": 410, "protein_name": "Gustatory receptor-like 36a", "gene_name": "Grl36a", "organism": "Fruit fly", "refseq_name": "gustatory receptor-like 36a", "refseq_ac": [ { "id": "NP_724041", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724041", "type": "external" } ], "gene_names_uniprotkb": "Grl36a; CG31750", "gene_names_refseq": "CG31750; Dmel\\CG31750; Gr36d; Grl36a", "protein_names_uniprotkb": "Gustatory receptor-like 36a", "protein_names_refseq": "CG31750-PA; Gr36d; Grl36a-PA; gustatory receptor-like 36a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31750)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022834 ligand-gated channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8INZ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8INZ2-1", "uniprot_id": [ { "id": "GR36C_DROME", "url": "https://www.uniprot.org/uniprot/Q8INZ2", "type": "external" } ], "mass": 45264.0, "length": 390, "protein_name": "Putative gustatory receptor 36c", "gene_name": "Gr36c", "organism": "Fruit fly", "refseq_name": "gustatory receptor 36c", "refseq_ac": [ { "id": "NP_724040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724040", "type": "external" } ], "gene_names_uniprotkb": "Gr36c; CG31748", "gene_names_refseq": "CG15137; CG31748; Dmel\\CG31748; GR36c; Gr36B.3; Gr36B3; Gr36c", "protein_names_uniprotkb": "Putative gustatory receptor 36c", "protein_names_refseq": "CG31748-PA; Gr36c-PA; gustatory receptor 36B3; gustatory receptor 36c", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31748)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;11516643;12537572;22031876", "class_list": "", "function": "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0008527 taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007165 signal transduction;GO:0034220 monoatomic ion transmembrane transport;GO:0050909 sensory perception of taste", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8INZ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IP68-1", "uniprot_id": [ { "id": "NEMU_DROME", "url": "https://www.uniprot.org/uniprot/Q8IP68", "type": "external" } ], "mass": 19196.0, "length": 172, "protein_name": "Protein nemuri", "gene_name": "nur", "organism": "Fruit fly", "refseq_name": "nemuri, isoform B", "refseq_ac": [ { "id": "NP_001285906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285906", "type": "external" } ], "gene_names_uniprotkb": "nur; CG31813", "gene_names_refseq": "BG:DS08249.4; BcDNA:RE62259; CG31813; Dmel\\CG31813; nur", "protein_names_uniprotkb": "Protein nemuri", "protein_names_refseq": "CG31813-PB; nemuri, isoform B; nemuri; nur-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31813)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;30705188", "class_list": "", "function": "Antimicrobial protein which is essential for the homeostatic regulation of sleep. Promotes sleep following sleep deprivation or bacterial infection and increases survival following bacterial infection. Likely to promote survival to bacterial infection in two ways; by contributing to the innate immune response and by promoting sleep during sickness to aid recovery., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IGM6", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0045087 innate immune response;GO:0030431 sleep;GO:0042742 defense response to bacterium;GO:0019730 antimicrobial humoral response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8IP68-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IPJ1-1", "uniprot_id": [ { "id": "Q8IPJ1_DROME", "url": "https://www.uniprot.org/uniprot/Q8IPJ1", "type": "external" } ], "mass": 21129.0, "length": 207, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG17377; anon-WO0140519.32", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform E", "refseq_ac": [ { "id": "NP_723220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_723220", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG17377; anon-WO0140519.32; BEST:LP06279; CG17377; Dmel\\CG17377; Dmel_CG17377; anon-WO0140519.32", "gene_names_refseq": "BEST:LP06279; CG17377; Dmel\\CG17377; anon-WO0140519.32", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG17377-PE; uncharacterized protein, isoform E", "tax_id": 7227, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8IPJ1-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IPK4-1", "uniprot_id": [ { "id": "GLT25_DROME", "url": "https://www.uniprot.org/uniprot/Q8IPK4", "type": "external" } ], "mass": 71149.0, "length": 612, "protein_name": "Glycosyltransferase 25 family member", "gene_name": "CG31915", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_723087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_723087", "type": "external" } ], "gene_names_uniprotkb": "CG31915", "gene_names_refseq": "CG31915; CG6922; Dmel\\CG31915", "protein_names_uniprotkb": "Glycosyltransferase 25 family member; 2.-.-.-", "protein_names_refseq": "CG31915-PA; uncharacterized protein", "tax_id": 7227, "disease": "brain small vessel disease 3 (Disease Ontology:DOID:0112315)", "pathway": " (dme:Dmel_CG31915); (R-DME-1650814)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A9UNF8", "ec_number_list": [ { "id": "2.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.-.-.-", "type": "external" } ], "go_molecular_function": "GO:0050211 procollagen galactosyltransferase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:1904028 positive regulation of collagen fibril organization;GO:0180062 protein O-linked glycosylation via galactose", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8IPK4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IPQ6-1", "uniprot_id": [ { "id": "Q8IPQ6_DROME", "url": "https://www.uniprot.org/uniprot/Q8IPQ6", "type": "external" } ], "mass": 47992.0, "length": 431, "protein_name": "Polymerase (DNA-directed), delta interacting protein 2, isoform B", "gene_name": "POLDIP2", "organism": "Fruit fly", "refseq_name": "polymerase (DNA-directed), delta interacting protein 2, isoform B", "refseq_ac": [ { "id": "NP_730934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_730934", "type": "external" } ], "gene_names_uniprotkb": "POLDIP2; CG12162; Dmel\\CG12162; Dmel_CG12162", "gene_names_refseq": "CG12162; Dmel\\CG12162; POLDIP2", "protein_names_uniprotkb": "Polymerase (DNA-directed), delta interacting protein 2, isoform B", "protein_names_refseq": "CG12162-PB; POLDIP2-PB; polymerase (DNA-directed), delta interacting protein 2, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12162)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0070987 error-free translesion synthesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8IPQ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IQ05-1", "uniprot_id": [ { "id": "CTF18_DROME", "url": "https://www.uniprot.org/uniprot/Q8IQ05", "type": "external" } ], "mass": 111749.0, "length": 993, "protein_name": "Chromosome transmission fidelity protein 18 homolog", "gene_name": "cutlet", "organism": "Fruit fly", "refseq_name": "cutlet", "refseq_ac": [ { "id": "NP_787969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787969", "type": "external" } ], "gene_names_uniprotkb": "cutlet; CG33122", "gene_names_refseq": "CG10030; CG33122; Ctf18; Dmel\\CG33122; chl12; ctl; cutlet", "protein_names_uniprotkb": "Chromosome transmission fidelity protein 18 homolog; CTF18; Cutlet protein", "protein_names_refseq": "CG33122-PA; cutlet-PA; cutlet; gilead", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33122); (R-DME-174411)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;11161570;12537572", "class_list": "", "function": "Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA and has weak ATPase activity. The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q95WV5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031390 Ctf18 RFC-like complex", "go_biological_process": "GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8IQ05-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IQ70-1", "uniprot_id": [ { "id": "MCU_DROME", "url": "https://www.uniprot.org/uniprot/Q8IQ70", "type": "external" } ], "mass": 42478.0, "length": 366, "protein_name": "Calcium uniporter protein, mitochondrial", "gene_name": "MCU", "organism": "Fruit fly", "refseq_name": "mitochondrial calcium uniporter, isoform H", "refseq_ac": [ { "id": "NP_001246647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246647", "type": "external" } ], "gene_names_uniprotkb": "MCU; CG18769", "gene_names_refseq": "CG18769; CG8352; Dmel\\CG18769; MCU; Mcu; dMCU1; mcu", "protein_names_uniprotkb": "Calcium uniporter protein, mitochondrial; Mitochondrial calcium uniporter", "protein_names_refseq": "CG18769-PH; MCU-PH; mitochondrial calcium uniporter, isoform H; mitochondrial calcium uniporter", "tax_id": 7227, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700)", "pathway": " (dme:Dmel_CG18769); (R-DME-8949215); (R-DME-8949664)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;12537572;27568554;28726639;33296646", "class_list": "", "function": "Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:28726639, PubMed:33296646). Constitutes a pore-forming and calcium-conducting subunit (PubMed:28726639, PubMed:33296646). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways (PubMed:28726639). Together with Itpr, has a role in oxidative stress-induced ER-mitochondria calcium transfer (PubMed:28726639). During pupation, required for memory function in mushroom body neurons (PubMed:27568554)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E1NZC4;M9NF23;Q7KU70;X2JAQ2", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0015292 uniporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:1990246 uniplex complex", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0006851 mitochondrial calcium ion transmembrane transport;GO:0036444 calcium import into the mitochondrion;GO:0051560 mitochondrial calcium ion homeostasis;GO:0007615 anesthesia-resistant memory", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8IQ70-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IQJ5-1", "uniprot_id": [ { "id": "Q8IQJ5_DROME", "url": "https://www.uniprot.org/uniprot/Q8IQJ5", "type": "external" } ], "mass": 69570.0, "length": 648, "protein_name": "Uncharacterized protein", "gene_name": "tono", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_001097599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097599", "type": "external" } ], "gene_names_uniprotkb": "tono; CG32121; Dmel\\CG32121; Dmel_CG32121", "gene_names_refseq": "CG32121; Dmel\\CG32121", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG32121-PB; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32121)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0003006 developmental process involved in reproduction;GO:0006357 regulation of transcription by RNA polymerase II;GO:0048468 cell development;GO:0048513 animal organ development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8IQJ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IQV9-1", "uniprot_id": [ { "id": "NU205_DROME", "url": "https://www.uniprot.org/uniprot/Q8IQV9", "type": "external" } ], "mass": 235147.0, "length": 2090, "protein_name": "Nuclear pore complex protein Nup205", "gene_name": "Nup205", "organism": "Fruit fly", "refseq_name": "nucleoporin 205kD, isoform A", "refseq_ac": [ { "id": "NP_608362", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608362", "type": "external" } ], "gene_names_uniprotkb": "Nup205; CG11943", "gene_names_refseq": "CG11943; Dmel\\CG11943; Nup205; Ov4; anon-EST:Posey281; nup205", "protein_names_uniprotkb": "Nuclear pore complex protein Nup205; 205 kDa nucleoporin; Nucleoporin Nup205", "protein_names_refseq": "CG11943-PA; Nup205-PA; nucleoporin 205kD, isoform A; nucleoporin 205", "tax_id": 7227, "disease": "nephrotic syndrome type 13 (Disease Ontology:DOID:0080381)", "pathway": " (dme:Dmel_CG11943); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236); (R-DME-1855170); (R-DME-1855196); (R-DME-1855229); (R-DME-3108214); (R-DME-3301854); (R-DME-3371453); (R-DME-4085377); (R-DME-4551638); (R-DME-4615885); (R-DME-9615933)", "pathway_count": 15, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;15917496;20547758", "class_list": "", "function": "Plays a role in the nuclear pore complex (NPC) assembly and maintenance, but with limited role in NPC permeability. Required for specific nuclear import pathways such as Mad import., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B6IDH1;Q3YMV0;Q8MSV6;Q9VWB8", "ec_number_list": [], "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0044611 nuclear pore inner ring", "go_biological_process": "GO:0006999 nuclear pore organization;GO:0006913 nucleocytoplasmic transport;GO:0051028 mRNA transport;GO:0006606 protein import into nucleus;GO:0042332 gravitaxis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8IQV9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IR22-1", "uniprot_id": [ { "id": "Q8IR22_DROME", "url": "https://www.uniprot.org/uniprot/Q8IR22", "type": "external" } ], "mass": 1769756.0, "length": 16223, "protein_name": "Mucin 14A", "gene_name": "Muc14A", "organism": "Fruit fly", "refseq_name": "mucin 14A", "refseq_ac": [ { "id": "NP_727928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_727928", "type": "external" } ], "gene_names_uniprotkb": "Muc14A; CG32580; Dmel\\CG32580; Dmel_CG32580; muc14a", "gene_names_refseq": "CG32580; Dmel\\CG32580; Muc14A; muc14a", "protein_names_uniprotkb": "Mucin 14A", "protein_names_refseq": "CG32580-PA; Muc14A-PA; Mucin14A; mucin 14A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32580)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q8IR22-1", "record_type": "protein", "filter_code": "0000000.0000101.000010.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IRH5-1", "uniprot_id": [ { "id": "INDRA_DROME", "url": "https://www.uniprot.org/uniprot/Q8IRH5", "type": "external" } ], "mass": 81992.0, "length": 733, "protein_name": "Zinc finger protein indra", "gene_name": "indra", "organism": "Fruit fly", "refseq_name": "indra, isoform C", "refseq_ac": [ { "id": "NP_001261252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261252", "type": "external" } ], "gene_names_uniprotkb": "indra; CG2199", "gene_names_refseq": "CG2199; Dmel\\CG2199; FBpp0072605; indra", "protein_names_uniprotkb": "Zinc finger protein indra", "protein_names_refseq": "CG2199-PC; indra, isoform C; indra-PC", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2199)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;17372656;18327897;35895823", "class_list": "", "function": "Required for rDNA copy number maintenance and non-random sister chromatid segregation (NRSS) following unequal sister chromatid exchange (PubMed:35895823). Binds ribosomal DNA (rDNA) preferentially binding to intergenic spacers (IGS) regions on both X and Y chromosomes (PubMed:35895823). Essential for NRSS, a mechanism which contributes to the recovery and maintenance of inherently unstable rDNA copy numbers so that the integrity of the germline genome is upheld over generations and germline immortality is sustained (PubMed:35895823). May be involved in transcriptional regulation (Probable)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9UNC2;H0RNL4;M9PBH8;Q29R03;Q6NNC3;Q960W3;Q9W0G3", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000182 rDNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0043007 maintenance of rDNA", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8IRH5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IRI6-5", "uniprot_id": [ { "id": "GTR1_DROME", "url": "https://www.uniprot.org/uniprot/Q8IRI6", "type": "external" } ], "mass": 158555.0, "length": 1440, "protein_name": "Glucose transporter type 1", "gene_name": "Glut1", "organism": "Fruit fly", "refseq_name": "glucose transporter 1, isoform D", "refseq_ac": [ { "id": "NP_001097467", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097467", "type": "external" } ], "gene_names_uniprotkb": "Glut1; CG43946", "gene_names_refseq": "0074/12; CG1086; CG13908; CG43946; DmGLUT1; DmGluT1; Dmel\\CG43946; Dmglut1; GLUT1; GLUT; GLU; Glt1; Glu T1; Glut-1; Glut1; Glut; glut1; l(3)61Ea; l(3)L1H; l(3)S007412", "protein_names_uniprotkb": "Glucose transporter type 1", "protein_names_refseq": "CG43946-PD; Glut1-PD; glucose transporter 1, isoform D; glucose transporter 1; lethal (3) S007412", "tax_id": 7227, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); myelomeningocele (Disease Ontology:DOID:0060326); glucose transporter type 1 deficiency syndrome (Disease Ontology:DOID:0070560); glucose transporter type 1 deficiency syndrome 1 (Disease Ontology:DOID:0070561); dystonia 9 (Disease Ontology:DOID:0090044); glucose transporter type 1 deficiency syndrome 2 (Disease Ontology:DOID:0090045); Hirschsprung's disease (Disease Ontology:DOID:10487); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hypothyroidism (Disease Ontology:DOID:1459); childhood absence epilepsy (Disease Ontology:DOID:1825); nephroblastoma (Disease Ontology:DOID:2154); hemangioma (Disease Ontology:DOID:255); acanthosis nigricans (Disease Ontology:DOID:3138); middle cerebral artery infarction (Disease Ontology:DOID:3525); cataract (Disease Ontology:DOID:83); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG43946); (R-DME-189200); (R-DME-196836); (R-DME-422356); (R-DME-5653890); (R-DME-6798695); (R-DME-8981373)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "10479996;10731132;12537569;12537572", "class_list": "", "function": "Facilitative glucose transporter., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 20, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A8JNH6;A8JNH8;A8JNH9;M9PBH4;M9PBH5;M9PDK7;M9PDL1;M9PDS4;M9PDS9;M9PE46;M9PGN5;M9PGP2;O77131;Q0E8K0;Q6NNA9;Q95TE8;Q9V409;Q9W0L2", "ec_number_list": [], "go_molecular_function": "GO:0015149 hexose transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0042593 glucose homeostasis;GO:0090277 positive regulation of peptide hormone secretion;GO:0015749 monosaccharide transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8IRI6-5", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IRL8-1", "uniprot_id": [ { "id": "GR09A_DROME", "url": "https://www.uniprot.org/uniprot/Q8IRL8", "type": "external" } ], "mass": 39131.0, "length": 341, "protein_name": "Putative gustatory receptor 9a", "gene_name": "Gr9a", "organism": "Fruit fly", "refseq_name": "gustatory receptor 9a", "refseq_ac": [ { "id": "NP_727392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_727392", "type": "external" } ], "gene_names_uniprotkb": "Gr9a; CG32693", "gene_names_refseq": "CG32693; Dmel\\CG32693; GR9a; Gr9a", "protein_names_uniprotkb": "Putative gustatory receptor 9a", "protein_names_refseq": "CG32693-PA; Gr9a-PA; gustatory receptor 9a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32693)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;22031876", "class_list": "", "function": "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0008527 taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0008049 male courtship behavior;GO:0007165 signal transduction;GO:0034220 monoatomic ion transmembrane transport;GO:0007635 chemosensory behavior;GO:0050912 detection of chemical stimulus involved in sensory perception of taste", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8IRL8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IRW8-1", "uniprot_id": [ { "id": "TRR_DROME", "url": "https://www.uniprot.org/uniprot/Q8IRW8", "type": "external" } ], "mass": 259828.0, "length": 2431, "protein_name": "Histone-lysine N-methyltransferase trr", "gene_name": "trr", "organism": "Fruit fly", "refseq_name": "trithorax-related, isoform C", "refseq_ac": [ { "id": "NP_525040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525040", "type": "external" } ], "gene_names_uniprotkb": "trr; CG3848; KMT2C", "gene_names_refseq": "CG3848; Dmel\\CG3848; EG:63B12.3; TRR; Trr; anon-2Bb; dmll3/4; trr", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase trr; 2.1.1.354; Lysine N-methyltransferase 2C; Trithorax-related protein", "protein_names_refseq": "CG3848-PC; Trithorax-related; Trx-related; trithorax related; trithorax-related protein; trithorax-related, isoform C; trr-PC", "tax_id": 7227, "disease": "oral squamous cell carcinoma (Disease Ontology:DOID:0050866); Kabuki syndrome (Disease Ontology:DOID:0060473); Kleefstra syndrome 2 (Disease Ontology:DOID:0080598); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); intracranial aneurysm (Disease Ontology:DOID:10941); colon carcinoma (Disease Ontology:DOID:1520); breast cancer (Disease Ontology:DOID:1612); congenital heart disease (Disease Ontology:DOID:1682); breast carcinoma (Disease Ontology:DOID:3459); meningioma (Disease Ontology:DOID:3565); gastric adenocarcinoma (Disease Ontology:DOID:3717); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); papillary thyroid carcinoma (Disease Ontology:DOID:3969); lung small cell carcinoma (Disease Ontology:DOID:5409); primary ovarian insufficiency (Disease Ontology:DOID:5426); rheumatoid arthritis (Disease Ontology:DOID:7148); gastrointestinal lymphoma (Disease Ontology:DOID:903)", "pathway": " (dme:Dmel_CG3848); (R-DME-8936459); (R-DME-9772755); (R-DME-9909649)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "10354481;10731132;10731137;12537569;12537572;14603321;18327897;21875999;22726846;23197473;33925313;40245499", "class_list": "", "function": "Histone methyltransferase that acts as a coactivator for the ecdysone receptor during development. Specifically trimethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation. Recruited by EcR in an ecdysone-dependent manner causing H3 'Lys-4' trimethylation at ecdysone-inducible promoters, leading to activate expression. Plays a central role in the developing compound eye, during the progression of the morphogenetic furrow and in post-furrow differentiation of the retinal epithelium, notably by activating expression of hh (PubMed:14603321, PubMed:23197473). Also required for wing and abdominal development (PubMed:14603321, PubMed:22726846, PubMed:23197473)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 20, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O46083;Q8MYR5;Q8T9I7;Q9W548", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.370", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.370", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0005102 signaling receptor binding;GO:0008270 zinc ion binding;GO:0001046 core promoter sequence-specific DNA binding;GO:0042800 histone H3K4 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0044666 MLL3/4 complex;GO:0005700 polytene chromosome;GO:0005703 polytene chromosome puff", "go_biological_process": "GO:0048749 compound eye development;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "Q8IRW8-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IRZ5-1", "uniprot_id": [ { "id": "OR19B_DROME", "url": "https://www.uniprot.org/uniprot/Q8IRZ5", "type": "external" } ], "mass": 44157.0, "length": 387, "protein_name": "Putative odorant receptor 19b", "gene_name": "Or19b", "organism": "Fruit fly", "refseq_name": "odorant receptor 19b", "refseq_ac": [ { "id": "NP_728315", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_728315", "type": "external" } ], "gene_names_uniprotkb": "Or19b; CG32825", "gene_names_refseq": "CG32825; Dmel\\CG32825; OR19b; Odorant receptor-19b; Or-19b; Or19b", "protein_names_uniprotkb": "Putative odorant receptor 19b", "protein_names_refseq": "CG32825-PA; Or19b-PA; odorant receptor 19b", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32825)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;14608037", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8IRZ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8IS44-1", "uniprot_id": [ { "id": "DRD2L_DROME", "url": "https://www.uniprot.org/uniprot/Q8IS44", "type": "external" } ], "mass": 95057.0, "length": 905, "protein_name": "Dopamine D2-like receptor", "gene_name": "Dop2R", "organism": "Fruit fly", "refseq_name": "dopamine 2-like receptor, isoform F", "refseq_ac": [ { "id": "NP_001014757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014757", "type": "external" } ], "gene_names_uniprotkb": "Dop2R; CG17004; D2R", "gene_names_refseq": "CG17004; CG33517; CG9569; D2R; DD2R; DmDOP3; Dmel\\CG33517; Dop2R; Dop2r; anon-WO0170980.130; anon-WO0170980.131; anon-WO0170980.31; anon-WO0170980.32; d2r; dD2R", "protein_names_uniprotkb": "Dopamine D2-like receptor; DD2R", "protein_names_refseq": "CG33517-PF; D2 autoreceptor; D2-like receptor; D[[2]] receptor; D[[2]]-like receptor; Dop2R-PF; dopamine 2-like receptor, isoform F; dopamine 2-like receptor; dopamine D2 receptor", "tax_id": 7227, "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); nicotine dependence (Disease Ontology:DOID:0050742); absence epilepsy (Disease Ontology:DOID:0070309); Parkinsonism (Disease Ontology:DOID:0080855); traumatic brain injury (Disease Ontology:DOID:0081292); essential tremor 1 (Disease Ontology:DOID:0111428); migraine with aura (Disease Ontology:DOID:10024); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); amnestic disorder (Disease Ontology:DOID:10914); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); hyperprolactinemia (Disease Ontology:DOID:12700); dementia (Disease Ontology:DOID:1307); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); drug psychosis (Disease Ontology:DOID:1742); anxiety disorder (Disease Ontology:DOID:2030); brain ischemia (Disease Ontology:DOID:2316); alcohol-induced mental disorder (Disease Ontology:DOID:251); opiate dependence (Disease Ontology:DOID:2559); morphine dependence (Disease Ontology:DOID:2560); toxic encephalopathy (Disease Ontology:DOID:3602); primary hyperaldosteronism (Disease Ontology:DOID:446); movement disease (Disease Ontology:DOID:480); essential tremor (Disease Ontology:DOID:4990); schizophrenia (Disease Ontology:DOID:5419); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); cocaine dependence (Disease Ontology:DOID:9975); heroin dependence (Disease Ontology:DOID:9976)", "pathway": " (dme:Dmel_CG33517); (R-DME-390651); (R-DME-418594)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10731132;12391323;12537572", "class_list": "", "function": "Receptor for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase., [UniProtKB, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 8, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 35, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "Q4ABK5;Q59E80;Q59E81;Q59E82;Q6AWL2;Q8IS43;Q8IS45;Q9W5X7;Q9W5X8;X2JLE1", "ec_number_list": [], "go_molecular_function": "GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go;GO:0004930 G protein-coupled receptor activity;GO:0008227 G protein-coupled amine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045202 synapse", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007212 G protein-coupled dopamine receptor signaling pathway;GO:0007615 anesthesia-resistant memory", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8IS44-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MKL1-1", "uniprot_id": [ { "id": "U598_DROME", "url": "https://www.uniprot.org/uniprot/Q8MKL1", "type": "external" } ], "mass": 25465.0, "length": 215, "protein_name": "UPF0598 protein CG30010", "gene_name": "CG30010", "organism": "Fruit fly", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CG30010", "gene_names_refseq": "", "protein_names_uniprotkb": "UPF0598 protein CG30010", "protein_names_refseq": "", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG30010)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4KFH5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0042060 wound healing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8MKL1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MLV1-1", "uniprot_id": [ { "id": "LBR_DROME", "url": "https://www.uniprot.org/uniprot/Q8MLV1", "type": "external" } ], "mass": 83185.0, "length": 741, "protein_name": "Lamin-B receptor", "gene_name": "LBR", "organism": "Fruit fly", "refseq_name": "lamin B receptor, isoform A", "refseq_ac": [ { "id": "NP_611608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611608", "type": "external" } ], "gene_names_uniprotkb": "LBR; CG17952", "gene_names_refseq": "CG17952; Dmel\\CG17952; LBR; dLBR", "protein_names_uniprotkb": "Lamin-B receptor; dLBR", "protein_names_refseq": "CG17952-PA; LBR-PA; lamin B receptor, isoform A; lamin B receptor; lamin-B receptor", "tax_id": 7227, "disease": "Greenberg dysplasia (Disease Ontology:DOID:0111588); primary biliary cholangitis (Disease Ontology:DOID:12236); Behcet's disease (Disease Ontology:DOID:13241); Smith-Lemli-Opitz syndrome (Disease Ontology:DOID:14692); ichthyosis vulgaris (Disease Ontology:DOID:1702); systemic lupus erythematosus (Disease Ontology:DOID:9074); Pelger-Huet anomaly (Disease Ontology:DOID:9631)", "pathway": " (dme:Dmel_CG17952); (R-DME-2995383); (R-DME-6807047)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;15054108;18327897;33925313;40245499", "class_list": "", "function": "Anchors the lamina and the heterochromatin to the inner nuclear membrane., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 11, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 11, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 11, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q0E8Z1;Q709R7;Q9W2D2", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005521 lamin binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0016126 sterol biosynthetic process;GO:0006997 nucleus organization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8MLV1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MLZ7-1", "uniprot_id": [ { "id": "IDGF3_DROME", "url": "https://www.uniprot.org/uniprot/Q8MLZ7", "type": "external" } ], "mass": 49255.0, "length": 441, "protein_name": "Chitinase-like protein Idgf3", "gene_name": "Idgf3", "organism": "Fruit fly", "refseq_name": "imaginal disc growth factor 3, isoform D", "refseq_ac": [ { "id": "NP_001285982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285982", "type": "external" } ], "gene_names_uniprotkb": "Idgf3; CG4559", "gene_names_refseq": "BG:DS02780.2; CG4559; DmIDGF3; Dmel\\CG4559; FBgn0020414; IDGF-3; IDGF3; IDGF; Idgf3; idgf3; lincRNA.163", "protein_names_uniprotkb": "Chitinase-like protein Idgf3; Imaginal disk growth factor protein 3", "protein_names_refseq": "CG4559-PD; Idgf3-PD; imaginal disc growth factor 3, isoform D; imaginal disc growth factor 3", "tax_id": 7227, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); small cell carcinoma (Disease Ontology:DOID:0050685); colorectal carcinoma (Disease Ontology:DOID:0080199); prostate carcinoma (Disease Ontology:DOID:10286); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); temporal arteritis (Disease Ontology:DOID:13375); pulmonary sarcoidosis (Disease Ontology:DOID:13406); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); arteriosclerosis (Disease Ontology:DOID:2349); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); glioblastoma (Disease Ontology:DOID:3068); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); chondrosarcoma (Disease Ontology:DOID:3371); coronary artery disease (Disease Ontology:DOID:3393); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); neuromyelitis optica (Disease Ontology:DOID:8869); acute myeloid leukemia (Disease Ontology:DOID:9119); type 2 diabetes mellitus (Disease Ontology:DOID:9352); bacterial meningitis (Disease Ontology:DOID:9470); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dme:Dmel_CG4559); (R-DME-189085); (R-DME-6798695)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10471707;10731132;12242232;12537569;12537572;9847235", "class_list": "", "function": "Cooperates with insulin-like peptides to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 33, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4V0S4;O96666;Q8MM23;Q8MX33;Q8MX34;Q8MX35;Q8MX36;Q8MX37;Q8MX38;Q8MX39;Q9V3B9;X2JA18", "ec_number_list": [], "go_molecular_function": "GO:0008061 chitin binding;GO:0008084 imaginal disc growth factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0042060 wound healing;GO:0006032 chitin catabolic process;GO:0007444 imaginal disc development;GO:0018990 ecdysis, chitin-based cuticle", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8MLZ7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MM24-1", "uniprot_id": [ { "id": "IDGF1_DROME", "url": "https://www.uniprot.org/uniprot/Q8MM24", "type": "external" } ], "mass": 49376.0, "length": 439, "protein_name": "Chitinase-like protein Idgf1", "gene_name": "Idgf1", "organism": "Fruit fly", "refseq_name": "imaginal disc growth factor 1", "refseq_ac": [ { "id": "NP_477258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477258", "type": "external" } ], "gene_names_uniprotkb": "Idgf1; CG4472", "gene_names_refseq": "BG:DS02780.5; CG4472; DmIDGF1; Dmel\\CG4472; IDGF-1; IDGF1; IDGF; Idgf1; idgf1; ldgf1", "protein_names_uniprotkb": "Chitinase-like protein Idgf1; Imaginal disk growth factor protein 1", "protein_names_refseq": "CG4472-PA; Idgf1-PA; imaginal disc growth factor 1; imaginal disc growth factor1", "tax_id": 7227, "disease": "invasive aspergillosis (Disease Ontology:DOID:0050073); idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); small cell carcinoma (Disease Ontology:DOID:0050685); colorectal carcinoma (Disease Ontology:DOID:0080199); prostate carcinoma (Disease Ontology:DOID:10286); pre-eclampsia (Disease Ontology:DOID:10591); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); temporal arteritis (Disease Ontology:DOID:13375); pulmonary sarcoidosis (Disease Ontology:DOID:13406); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); arteriosclerosis (Disease Ontology:DOID:2349); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); glioblastoma (Disease Ontology:DOID:3068); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); chondrosarcoma (Disease Ontology:DOID:3371); coronary artery disease (Disease Ontology:DOID:3393); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); neuromyelitis optica (Disease Ontology:DOID:8869); acute myeloid leukemia (Disease Ontology:DOID:9119); type 2 diabetes mellitus (Disease Ontology:DOID:9352); bacterial meningitis (Disease Ontology:DOID:9470); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dme:Dmel_CG4472); (R-DME-189085); (R-DME-6798695)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "10471707;10731132;12242232;12537569;12537572;17893096;9847235", "class_list": "", "function": "Cooperates with insulin-like peptides to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 33, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O96664;Q8MM30;Q8MM31;Q8MM38;Q8MM92;Q8MX42;Q8MX43;Q8MX44;Q8MX45;Q8MX46;Q8MX47;Q8MX48;Q8MX49;Q8MX50;Q9V3P8", "ec_number_list": [], "go_molecular_function": "GO:0008061 chitin binding;GO:0008084 imaginal disc growth factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0042060 wound healing;GO:0006032 chitin catabolic process;GO:2000035 regulation of stem cell division;GO:0007444 imaginal disc development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q8MM24-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MMF9-1", "uniprot_id": [ { "id": "OB57D_DROME", "url": "https://www.uniprot.org/uniprot/Q8MMF9", "type": "external" } ], "mass": 15747.0, "length": 136, "protein_name": "General odorant-binding protein 57d", "gene_name": "Obp57d", "organism": "Fruit fly", "refseq_name": "Odorant-binding protein 57d", "refseq_ac": [ { "id": "NP_725973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_725973", "type": "external" } ], "gene_names_uniprotkb": "Obp57d; CG30150", "gene_names_refseq": "57d; CG30150; DmelObp57d; Dmel\\CG30150; Dmel\\Obp57d; OBP57d; Obp-g; Obp57d; Obp57e; anon-AE003791.1", "protein_names_uniprotkb": "General odorant-binding protein 57d", "protein_names_refseq": "CG30150-PB; Obp57d-PB; Odorant-binding protein 57d", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG30150)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12119098;12213773;12537572", "class_list": "", "function": "Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5KS14;Q5KS20;Q5KS26;Q5KS32;Q5KS34;Q8MVX5", "ec_number_list": [], "go_molecular_function": "GO:0005549 odorant binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007608 sensory perception of smell;GO:0007606 sensory perception of chemical stimulus;GO:1990834 response to odorant", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8MMF9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MPP0-1", "uniprot_id": [ { "id": "NIJA_DROME", "url": "https://www.uniprot.org/uniprot/Q8MPP0", "type": "external" } ], "mass": 26491.0, "length": 245, "protein_name": "Ninjurin-A", "gene_name": "NijA", "organism": "Fruit fly", "refseq_name": "ninjurin A, isoform D", "refseq_ac": [ { "id": "NP_001261687", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261687", "type": "external" } ], "gene_names_uniprotkb": "NijA; CG6449; ninA", "gene_names_refseq": "CG6449; Dmel\\CG6449; NINJ-A; NijA; nijA; nija; ninA", "protein_names_uniprotkb": "Ninjurin-A; dNINJ-A", "protein_names_refseq": "CG6449-PD; NijA-PD; ninjurin A, isoform D; ninjurin A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6449)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;16815999;23028562;33472215", "class_list": "", "function": "Effector of non-apoptotic necrotic cell death that mediates plasma membrane rupture (cytolysis): oligomerizes in response to death stimuli and promotes plasma membrane rupture by introducing hydrophilic faces of 2 alpha helices into the hydrophobic membrane, leading to release intracellular molecules that propagate the inflammatory response (PubMed:23028562, PubMed:33472215). Also acts as a homophilic transmembrane adhesion molecule that promotes cell adhesion by mediating homophilic interactions via its extracellular region (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Secreted form generated by cleavage, which acts as a negative regulator of cell adhesion (PubMed:16815999). Promotes the loss of cell adhesion in a cell non-autonomous manner (PubMed:16815999)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "M9PHZ8;Q8MPN9;Q8SYI2;Q9VTB5", "ec_number_list": [], "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0042246 tissue regeneration;GO:0031640 killing of cells of another organism;GO:0019835 cytolysis;GO:0012501 programmed cell death", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8MPP0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MR62-1", "uniprot_id": [ { "id": "PHLP2_DROME", "url": "https://www.uniprot.org/uniprot/Q8MR62", "type": "external" } ], "mass": 27440.0, "length": 240, "protein_name": "Phosducin-like protein 2", "gene_name": "PhLP2", "organism": "Fruit fly", "refseq_name": "viral IAP-associated factor", "refseq_ac": [ { "id": "NP_524032", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524032", "type": "external" } ], "gene_names_uniprotkb": "PhLP2; CG18593; viaf1; viaf", "gene_names_refseq": "CG18593; Dmel\\CG18593; VIAF; Viaf; anon-WO0134798.17; anon-WO0134798.18; viaf1; viaf", "protein_names_uniprotkb": "Phosducin-like protein 2; Viral IAP-associated factor; Viral inhibitor of apoptosis-associated factor homolog", "protein_names_refseq": "CG18593-PA; viaf-PA; viral IAP-associated factor", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18593)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;15371430;18327897", "class_list": "", "function": "Modulates the activation of caspases during apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86G89;Q9VTS2", "ec_number_list": [], "go_molecular_function": "GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0006915 apoptotic process;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8MR62-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MRQ4-1", "uniprot_id": [ { "id": "LMBD2_DROME", "url": "https://www.uniprot.org/uniprot/Q8MRQ4", "type": "external" } ], "mass": 78440.0, "length": 694, "protein_name": "LMBR1 domain-containing protein 2 homolog", "gene_name": "CG8135", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_649890", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649890", "type": "external" } ], "gene_names_uniprotkb": "CG8135", "gene_names_refseq": "CG8135; Dmel\\CG8135", "protein_names_uniprotkb": "LMBR1 domain-containing protein 2 homolog", "protein_names_refseq": "CG8135-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8135)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9VHE2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8MRQ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MSS1-1", "uniprot_id": [ { "id": "LVA_DROME", "url": "https://www.uniprot.org/uniprot/Q8MSS1", "type": "external" } ], "mass": 315900.0, "length": 2779, "protein_name": "Protein lava lamp", "gene_name": "lva", "organism": "Fruit fly", "refseq_name": "lava lamp, isoform D", "refseq_ac": [ { "id": "NP_001284849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284849", "type": "external" } ], "gene_names_uniprotkb": "lva; ABP2; CG#6450; CG6450; Dmel\\CG6450; Dmel_CG6450; LVA_DROME; LVA; Lava; Lva; Lvl; lava; lvl", "gene_names_refseq": "ABP2; CG#6450; CG6450; Dmel\\CG6450; LVA_DROME; LVA; Lava; Lva; Lvl; lava; lva; lvl", "protein_names_uniprotkb": "Protein lava lamp", "protein_names_refseq": "CG6450-PD; LAVA LAMP; Lava-Lamp; actin-binding protein 2; lava lamp, isoform D; lavalamp; lva-PD", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6450)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;11076973;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;22493244;25589440;26109356;26109357;40245499", "class_list": "", "function": "Lva and spectrin may form a Golgi-based scaffold that mediates interaction of Golgi bodies with microtubules and facilitates Golgi-derived membrane secretion required for the formation of furrows during cellularization (PubMed:11076973). Under starvation conditions recruited by ema to developing autophagsosomes where it may function in autophagosome growth (PubMed:22493244)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9W4N7", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0051015 actin filament binding;GO:0030507 spectrin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0031410 cytoplasmic vesicle;GO:0032982 myosin filament;GO:0005776 autophagosome", "go_biological_process": "GO:0051683 establishment of Golgi localization;GO:0050775 positive regulation of dendrite morphogenesis;GO:0007349 cellularization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q8MSS1-1", "record_type": "protein", "filter_code": "0000000.0000101.001000.000000100000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8MVS5-1", "uniprot_id": [ { "id": "GLT35_DROME", "url": "https://www.uniprot.org/uniprot/Q8MVS5", "type": "external" } ], "mass": 71828.0, "length": 632, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 35A", "gene_name": "Pgant35A", "organism": "Fruit fly", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 35A", "refseq_ac": [ { "id": "NP_652069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_652069", "type": "external" } ], "gene_names_uniprotkb": "Pgant35A; CG7480", "gene_names_refseq": "A3; BG:DS01068.8; CG7480; Dmel\\CG7480; GalNAc-T; Pgant35A; Pgant35a; br12; dGalNAc-T1; l(2)35Aa; l(2)br12; l35Aa; pgant35A; pgant35; ppGalNAcT35A", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 35A; 2.4.1.41; Protein l(2)35Aa; Protein-UDP acetylgalactosaminyltransferase 35A; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 35A; dGalNAc-T1; pp-GaNTase 35A", "protein_names_refseq": "CG7480-PA; Pgant35A-PA; lethal 12 in the black-reduced region; lethal group A3; polypeptide N-acetylgalactosaminyltransferase 35A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7480); (R-DME-913709)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10471707;10731132;11925446;11925450;12537569;12537572;12829714;16251381;17893096;20422447;20807760;22157008;25253852", "class_list": "glycogene;glycosyltransferase", "function": "Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:11925450, PubMed:12829714). Displays the same enzyme activity toward MUC1, MUC4, and EA2 (PubMed:11925450, PubMed:12829714). Not involved in glycosylation of erythropoietin (EPO) (PubMed:11925450). It can both act as a peptide transferase that transfers GalNAc onto unmodified peptide substrates, and as a glycopeptide transferase that requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties (PubMed:11925450, PubMed:12829714). Protein modification by this enzyme might be important for cytokinesis and tube formation during embryogenesis (PubMed:16251381, PubMed:20807760). Together with Pgant3, regulates integrin levels and activity-dependent integrin signaling at the synapse in neurons and muscles (PubMed:25253852)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q8MVS2;Q8MVS3;Q8MVS4;Q8SYF1;Q965E4;Q9V3C9", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005112 Notch binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005795 Golgi stack", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine;GO:0008593 regulation of Notch signaling pathway;GO:0007424 open tracheal system development", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q8MVS5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000011000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8SXT3-1", "uniprot_id": [ { "id": "HFW2_DROME", "url": "https://www.uniprot.org/uniprot/Q8SXT3", "type": "external" } ], "mass": 58032.0, "length": 499, "protein_name": "Protein singed wings 2", "gene_name": "swi2", "organism": "Fruit fly", "refseq_name": "swi2", "refseq_ac": [ { "id": "NP_611247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611247", "type": "external" } ], "gene_names_uniprotkb": "swi2; CG14485", "gene_names_refseq": "CG14485; Dmel\\CG14485; swi2", "protein_names_uniprotkb": "Protein singed wings 2", "protein_names_refseq": "CG14485-PA; swi2-PA; swi2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14485); (R-DME-388844)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;15189568", "class_list": "", "function": "Has a role in the ecdysone induced cascade; probably indirect control of 'late' ecdysone genes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V863", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0035073 pupariation;GO:0035075 response to ecdysone", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8SXT3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8SXY6-1", "uniprot_id": [ { "id": "TMEDA_DROME", "url": "https://www.uniprot.org/uniprot/Q8SXY6", "type": "external" } ], "mass": 23692.0, "length": 206, "protein_name": "Transmembrane emp24 domain-containing protein bai", "gene_name": "bai", "organism": "Fruit fly", "refseq_name": "baiser", "refseq_ac": [ { "id": "NP_651323", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651323", "type": "external" } ], "gene_names_uniprotkb": "bai; CG11785", "gene_names_refseq": "150547_at; BAI; Bai; BcDNA:RE52411; CG11785; Dmel\\CG11785; bai; p23; p24", "protein_names_uniprotkb": "Transmembrane emp24 domain-containing protein bai; Protein baiser", "protein_names_refseq": "CG11785-PA; bai-PA; baiser", "tax_id": 7227, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (dme:Dmel_CG11785); (R-DME-6807878); (R-DME-6811434)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;15327786;16951084;19126864", "class_list": "", "function": "Eca and bai are essential, though not redundant, for dorsoventral patterning of the embryo. Specifically required during early embryogenesis for the activity of maternal tkv, while the zygotic tkv is not affected., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AQ60;A0AQ63;A0AQ65;C0MKQ9;Q9VBZ4", "ec_number_list": [], "go_molecular_function": "GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0012505 endomembrane system", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0009953 dorsal/ventral pattern formation;GO:0007030 Golgi organization;GO:0048193 Golgi vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8SXY6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8SY96-1", "uniprot_id": [ { "id": "NFU1_DROME", "url": "https://www.uniprot.org/uniprot/Q8SY96", "type": "external" } ], "mass": 31296.0, "length": 283, "protein_name": "NFU1 iron-sulfur cluster scaffold homolog, mitochondrial", "gene_name": "CG32500; CG32857; CG33502", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_728443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_728443", "type": "external" } ], "gene_names_uniprotkb": "CG32500; CG32857; CG33502", "gene_names_refseq": "CG32857; Dmel\\CG32857; Nfu", "protein_names_uniprotkb": "NFU1 iron-sulfur cluster scaffold homolog, mitochondrial", "protein_names_refseq": "CG32857-PA; uncharacterized protein", "tax_id": 7227, "disease": "hereditary spastic paraplegia 93 (Disease Ontology:DOID:0070645); multiple mitochondrial dysfunctions syndrome 1 (Disease Ontology:DOID:0080133)", "pathway": " (dme:Dmel_CG32500); (dme:Dmel_CG32857); (dme:Dmel_CG33502); (R-DME-9857492)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Molecular scaffold for [Fe-S] cluster assembly of mitochondrial iron-sulfur proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9I806;Q9U4F4", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0051539 4 iron, 4 sulfur cluster binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8SY96-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8SZ63-1", "uniprot_id": [ { "id": "GOGA5_DROME", "url": "https://www.uniprot.org/uniprot/Q8SZ63", "type": "external" } ], "mass": 58680.0, "length": 516, "protein_name": "Golgin-84", "gene_name": "Golgin84", "organism": "Fruit fly", "refseq_name": "Golgin-84", "refseq_ac": [ { "id": "NP_651250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651250", "type": "external" } ], "gene_names_uniprotkb": "Golgin84; CG17785", "gene_names_refseq": "CG17785; Dmel\\CG17785; Golgin84; g84", "protein_names_uniprotkb": "Golgin-84", "protein_names_refseq": "CG17785-PA; Golgin-84 ortholog; Golgin-84; Golgin84-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17785)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12429822;12537569;12537572;18327897", "class_list": "", "function": "May be involved in maintaining Golgi structure and in intra-Golgi transport., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SYC2;Q9VC88", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042803 protein homodimerization activity;GO:0031267 small GTPase binding;GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0033106 cis-Golgi network membrane;GO:0031985 Golgi cisterna", "go_biological_process": "GO:0007030 Golgi organization;GO:0048193 Golgi vesicle transport;GO:0000301 retrograde transport, vesicle recycling within Golgi;GO:0099041 vesicle tethering to Golgi;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q8SZ63-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8SZZ8-1", "uniprot_id": [ { "id": "ICE2_DROME", "url": "https://www.uniprot.org/uniprot/Q8SZZ8", "type": "external" } ], "mass": 78896.0, "length": 684, "protein_name": "Little elongation complex subunit 2", "gene_name": "Ice2", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_650946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650946", "type": "external" } ], "gene_names_uniprotkb": "Ice2; CG10825", "gene_names_refseq": "CG10825; Dmel\\CG10825; Ice2", "protein_names_uniprotkb": "Little elongation complex subunit 2; Interactor of little elongator complex ELL subunit 2", "protein_names_refseq": "uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10825)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;22195968", "class_list": "", "function": "Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VDE0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0008023 transcription elongation factor complex;GO:0032783 super elongation complex", "go_biological_process": "GO:1905382 positive regulation of snRNA transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8SZZ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8T053-1", "uniprot_id": [ { "id": "KIPF_DROME", "url": "https://www.uniprot.org/uniprot/Q8T053", "type": "external" } ], "mass": 50496.0, "length": 434, "protein_name": "Zinc finger protein kipf", "gene_name": "kipf", "organism": "Fruit fly", "refseq_name": "kipferl, isoform B", "refseq_ac": [ { "id": "NP_001246973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246973", "type": "external" } ], "gene_names_uniprotkb": "kipf; CG2678; anon-84Eb", "gene_names_refseq": "B; CG2678; Dmel\\CG2678; Kipf; anon-84Eb; kipf", "protein_names_uniprotkb": "Zinc finger protein kipf; Protein kipferl", "protein_names_refseq": "CG2678-PB; kipf-PB; kipferl, isoform B; transcript B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2678)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;18327897;36193674;9601978", "class_list": "", "function": "DNA-binding zinc finger protein that recruits chromo domain protein rhino/rhi to specific chromatin regions enriched in H3K9me2/3 histone methylation, mediating piRNA (piwi-interacting RNA) biogenesis (PubMed:36193674). May bind to GC rich DNA sequences including a 5'-GRGGN-3' sequence motif (PubMed:36193674). Nucleates rhi/rhino accumulation and stabilizes its expansion (PubMed:36193674). Involved in piRNA transposon repression, particularly in the female ovary during oogenesis (PubMed:36193674)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D4G7A6;D4G7A7;O76205;Q9VHY3", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0031490 chromatin DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005694 chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0140543 positive regulation of piRNA transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8T053-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8T0B1-1", "uniprot_id": [ { "id": "NEPR1_DROME", "url": "https://www.uniprot.org/uniprot/Q8T0B1", "type": "external" } ], "mass": 14877.0, "length": 131, "protein_name": "Nuclear envelope phosphatase-regulatory subunit 1 homolog", "gene_name": "Cnep1r2", "organism": "Fruit fly", "refseq_name": "CTD nuclear envelope phosphatase 1 regulatory subunit 2, isoform B", "refseq_ac": [ { "id": "NP_648400", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648400", "type": "external" } ], "gene_names_uniprotkb": "Cnep1r2; CG8009", "gene_names_refseq": "BcDNA:LD14173; CG8009; Cnep1r2; Dmel\\CG8009; Nep1r2; NepIr2", "protein_names_uniprotkb": "Nuclear envelope phosphatase-regulatory subunit 1 homolog; CTD nuclear envelope phosphatase 1 regulatory subunit 2; Transmembrane protein 188", "protein_names_refseq": "CG8009-PB; CTD nuclear envelope phosphatase 1 regulatory subunit 2, isoform B; Cnep1r2-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8009); (R-DME-4419969)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "May form with the serine/threonine protein phosphatase l(1)G0269 an active complex dephosphorylating and activating lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VTA4", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0071595 Nem1-Spo7 phosphatase complex", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0010867 positive regulation of triglyceride biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8T0B1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8T0R7-1", "uniprot_id": [ { "id": "IDGF5_DROME", "url": "https://www.uniprot.org/uniprot/Q8T0R7", "type": "external" } ], "mass": 50108.0, "length": 444, "protein_name": "Chitinase-like protein Idgf5", "gene_name": "Idgf5", "organism": "Fruit fly", "refseq_name": "imaginal disc growth factor 5", "refseq_ac": [ { "id": "NP_611321", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611321", "type": "external" } ], "gene_names_uniprotkb": "Idgf5; CG5154", "gene_names_refseq": "CG5154; Cht14; DmIDGF5; Dmel\\CG5154; IDGF-5; IDGF5; IDGF; Idgf5; idgf5", "protein_names_uniprotkb": "Chitinase-like protein Idgf5; Imaginal disk growth factor protein 5", "protein_names_refseq": "CG5154-PA; Idgf5-PA; imaginal disc growth factor 5", "tax_id": 7227, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); small cell carcinoma (Disease Ontology:DOID:0050685); colorectal carcinoma (Disease Ontology:DOID:0080199); prostate carcinoma (Disease Ontology:DOID:10286); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); temporal arteritis (Disease Ontology:DOID:13375); pulmonary sarcoidosis (Disease Ontology:DOID:13406); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); arteriosclerosis (Disease Ontology:DOID:2349); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); glioblastoma (Disease Ontology:DOID:3068); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); chondrosarcoma (Disease Ontology:DOID:3371); coronary artery disease (Disease Ontology:DOID:3393); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); neuromyelitis optica (Disease Ontology:DOID:8869); acute myeloid leukemia (Disease Ontology:DOID:9119); type 2 diabetes mellitus (Disease Ontology:DOID:9352); bacterial meningitis (Disease Ontology:DOID:9470); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dme:Dmel_CG5154); (R-DME-189085); (R-DME-6798695)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Probably required to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 33, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9V8G4", "ec_number_list": [], "go_molecular_function": "GO:0008061 chitin binding;GO:0008084 imaginal disc growth factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0042060 wound healing;GO:0006032 chitin catabolic process;GO:0007444 imaginal disc development;GO:0040003 chitin-based cuticle development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8T0R7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8T3L6-1", "uniprot_id": [ { "id": "FABD_DROME", "url": "https://www.uniprot.org/uniprot/Q8T3L6", "type": "external" } ], "mass": 42086.0, "length": 379, "protein_name": "Probable malonyl-CoA-acyl carrier protein transacylase, mitochondrial", "gene_name": "beg", "organism": "Fruit fly", "refseq_name": "bad egg", "refseq_ac": [ { "id": "NP_648950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648950", "type": "external" } ], "gene_names_uniprotkb": "beg; CG7842", "gene_names_refseq": "CG7842; Dmel\\CG7842; beg", "protein_names_uniprotkb": "Probable malonyl-CoA-acyl carrier protein transacylase, mitochondrial; 2.3.1.39; Bad egg; MCT; [Acyl-carrier-protein] malonyltransferase", "protein_names_refseq": "CG7842-PA; bad egg; beg-PA", "tax_id": 7227, "disease": "optic atrophy (Disease Ontology:DOID:5723)", "pathway": " (dme:Dmel_CG7842); (R-DME-77289)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18245854", "class_list": "", "function": "Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the ACP protein. This suggests the existence of the biosynthesis of fatty acids in mitochondria (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B6IDQ4;Q9VVD5", "ec_number_list": [ { "id": "1.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100", "type": "external" }, { "id": "1.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.39", "type": "external" }, { "id": "2.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.38", "type": "external" }, { "id": "2.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.39", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "2.3.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.85", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "4.2.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.59", "type": "external" } ], "go_molecular_function": "GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity;GO:0140691 RNA folding chaperone", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0180026 mitochondrial small ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8T3L6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8T4E1-1", "uniprot_id": [ { "id": "GPI8_DROME", "url": "https://www.uniprot.org/uniprot/Q8T4E1", "type": "external" } ], "mass": 40368.0, "length": 355, "protein_name": "Putative GPI-anchor transamidase", "gene_name": "PIG-K", "organism": "Fruit fly", "refseq_name": "phosphatidylinositol glycan anchor biosynthesis class K", "refseq_ac": [ { "id": "NP_569968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569968", "type": "external" } ], "gene_names_uniprotkb": "PIG-K; CG4406", "gene_names_refseq": "CG4406; Dmel\\CG4406; EG:133E12.3; PIG-K; PIGK; cg4406", "protein_names_uniprotkb": "Putative GPI-anchor transamidase; 3.-.-.-; GPI transamidase; Phosphatidylinositol glycan anchor biosynthesis protein class K", "protein_names_refseq": "CG4406-PA; PIG-K-PA; phosphatidylinositol glycan anchor biosynthesis class K", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4406)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;10731137;12537569;12537572", "class_list": "", "function": "Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O46047;Q9W538", "ec_number_list": [], "go_molecular_function": "GO:0003923 GPI-anchor transamidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0042765 GPI-anchor transamidase complex", "go_biological_process": "GO:0006508 proteolysis;GO:0006506 GPI anchor biosynthetic process;GO:0016255 attachment of GPI anchor to protein", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8T4E1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8T8R1-1", "uniprot_id": [ { "id": "CNBP_DROME", "url": "https://www.uniprot.org/uniprot/Q8T8R1", "type": "external" } ], "mass": 17615.0, "length": 165, "protein_name": "CCHC-type zinc finger nucleic acid binding protein", "gene_name": "CNBP", "organism": "Fruit fly", "refseq_name": "CCHC-type zinc finger nucleic acid binding protein, isoform B", "refseq_ac": [ { "id": "NP_001188992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188992", "type": "external" } ], "gene_names_uniprotkb": "CNBP; CG3800", "gene_names_refseq": "BEST:GM06241; CG11716; CG3800; CNBP; Dmel\\CG3800; anon-EST:fe1B4; anon-EST:fe2B6; dCNBP", "protein_names_uniprotkb": "CCHC-type zinc finger nucleic acid binding protein; CCHC-type zinc finger protein CG3800", "protein_names_refseq": "CCHC-type zinc finger nucleic acid binding protein, isoform B; CG3800-PB; CNBP-PB; anon-fast-evolving-1B4; anon-fast-evolving-2B6", "tax_id": 7227, "disease": "myotonic dystrophy type 2 (Disease Ontology:DOID:0050759)", "pathway": " (dme:Dmel_CG3800)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;17372656;18327897;24275942", "class_list": "", "function": "Single-stranded DNA/RNA-binding protein with sequence specificity (By similarity). Binds G-rich elements in target mRNA coding sequences (By similarity). Prevents G-quadruplex structure formation in vitro, suggesting a role in supporting translation by resolving stable structures on mRNAs (By similarity). IRES trans-acting factor (ITAF) that can promote IRES-dependent translation of Myc mRNA (PubMed:24275942). Involved in the control of wing size by regulating Myc levels (PubMed:24275942)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4JD46", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0003727 single-stranded RNA binding;GO:0045182 translation regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:2000767 positive regulation of cytoplasmic translation;GO:0002192 IRES-dependent translational initiation of linear mRNA;GO:0007472 wing disc morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8T8R1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8T9B6-1", "uniprot_id": [ { "id": "MESD_DROME", "url": "https://www.uniprot.org/uniprot/Q8T9B6", "type": "external" } ], "mass": 21002.0, "length": 180, "protein_name": "LDLR chaperone boca", "gene_name": "boca", "organism": "Fruit fly", "refseq_name": "boca", "refseq_ac": [ { "id": "NP_724578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724578", "type": "external" } ], "gene_names_uniprotkb": "boca; CG30498", "gene_names_refseq": "Boca; CG1364; CG30498; Dmel\\CG30498; boca; dmBoca; l(2)43Ea", "protein_names_uniprotkb": "LDLR chaperone boca", "protein_names_refseq": "CG30498-PA; boca-PA; boca; lethal(2)43Ea", "tax_id": 7227, "disease": "osteogenesis imperfecta type 20 (Disease Ontology:DOID:0111849)", "pathway": " (dme:Dmel_CG30498)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;12581524", "class_list": "", "function": "Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wg pathway, since some LDLRs are coreceptors for the canonical Wnt pathway., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1Z712", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0045177 apical part of cell;GO:0012505 endomembrane system", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006457 protein folding;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8T9B6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q94526-1", "uniprot_id": [ { "id": "ORK1_DROME", "url": "https://www.uniprot.org/uniprot/Q94526", "type": "external" } ], "mass": 109290.0, "length": 1001, "protein_name": "Open rectifier potassium channel protein 1", "gene_name": "Ork1", "organism": "Fruit fly", "refseq_name": "open rectifier K[+] channel 1, isoform D", "refseq_ac": [ { "id": "NP_001285096", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285096", "type": "external" } ], "gene_names_uniprotkb": "Ork1; CG1615; Dmel\\CG1615; Dmel_CG1615; DorK; KCNK0; K[[2P]]; ORK-1; ORK1; ORK; Ork; anon-WO0161006.1; anon-WO0161006.22; anon-WO0161006.23; d-ORK1; dORK1; dORKC1; dORK; dOrk1; dOrk; ork1; ork", "gene_names_refseq": "CG1615; Dmel\\CG1615; DorK; KCNK0; K[[2P]]; ORK-1; ORK1; ORK; Ork1; Ork; anon-WO0161006.1; anon-WO0161006.22; anon-WO0161006.23; d-ORK1; dORK1; dORKC1; dORK; dOrk1; dOrk; ork1; ork", "protein_names_uniprotkb": "Open rectifier potassium channel protein 1; Two pore domain potassium channel Ork1", "protein_names_refseq": "CG1615-PD; Ork1-PD; open rectifier K+ channel 1; open rectifier K[+] channel 1, isoform D; open rectifier potassium channel", "tax_id": 7227, "disease": "heart conduction disease (Disease Ontology:DOID:10273); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (dme:Dmel_CG1615); (R-DME-1299344); (R-DME-1299503); (R-DME-5576886)", "pathway_count": 4, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;8917578", "class_list": "", "function": "Background potassium channel. Rectification is dependent on external potassium concentration. Acts as an outwardly rectifying channel but as external potassium levels increase, this is reversed., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "B5RIM4;Q0KHU1;Q32KC8;Q95TX7", "ec_number_list": [], "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity;GO:0042803 protein homodimerization activity;GO:0005267 potassium channel activity", "go_cellular_component": "GO:0034705 potassium channel complex;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0045475 locomotor rhythm;GO:0002027 regulation of heart rate;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q94526-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q94901-1", "uniprot_id": [ { "id": "LARK_DROME", "url": "https://www.uniprot.org/uniprot/Q94901", "type": "external" } ], "mass": 39912.0, "length": 352, "protein_name": "RNA-binding protein lark", "gene_name": "lark", "organism": "Fruit fly", "refseq_name": "lark, isoform A", "refseq_ac": [ { "id": "NP_523957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523957", "type": "external" } ], "gene_names_uniprotkb": "lark; CG8597", "gene_names_refseq": "CG8597; Dmel\\CG8597; LARK; Lark; dLARK; lark", "protein_names_uniprotkb": "RNA-binding protein lark", "protein_names_refseq": "CG8597-PA; lark, isoform A; lark-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8597); (R-DME-8941326)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "10731132;11560900;12537569;12537572;15452872;18327897;8307324;9120432;9491990", "class_list": "", "function": "Essential RNA-binding protein. May be required for circadian repression of eclosion. Also essential for nurse cell dumping during oogenesis, the process whereby the cytoplasmic contents of nurse cells are transferred to the oocyte late in its development., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V1L0", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0071013 catalytic step 2 spliceosome;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:2000767 positive regulation of cytoplasmic translation;GO:0009792 embryo development ending in birth or egg hatching;GO:0000278 mitotic cell cycle;GO:0030036 actin cytoskeleton organization;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q94901-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q95RG8-1", "uniprot_id": [ { "id": "GIT_DROME", "url": "https://www.uniprot.org/uniprot/Q95RG8", "type": "external" } ], "mass": 80773.0, "length": 731, "protein_name": "ARF GTPase-activating protein Git", "gene_name": "Git", "organism": "Fruit fly", "refseq_name": "G protein-coupled receptor kinase interacting ArfGAP", "refseq_ac": [ { "id": "NP_610599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610599", "type": "external" } ], "gene_names_uniprotkb": "Git; CG16728; arfgap2", "gene_names_refseq": "CG16728; CT37209; Dmel\\CG16728; GIT; Git; arfgap2; dGit; dgit; git", "protein_names_uniprotkb": "ARF GTPase-activating protein Git; ARF GAP GIT; G protein-coupled receptor kinase interacting ArfGAP; dGIT protein", "protein_names_refseq": "CG16728-PA; G protein-coupled receptor kinase interacting ArfGAP; G-protein-coupled receptor kinase-interacting protein; Git-PA", "tax_id": 7227, "disease": "attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); Huntington's disease (Disease Ontology:DOID:12858)", "pathway": " (dme:Dmel_CG16728); (R-DME-3928664); (R-DME-9013149); (R-DME-9013406); (R-DME-9013420); (R-DME-9013423); (R-DME-9013424)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;18996366;25792865", "class_list": "", "function": "GTPase-activating protein for ADP ribosylation factor family members, including ARF1. Multidomain scaffold protein that interacts with numerous proteins and therefore participates in many cellular functions, including receptor internalization, focal adhesion remodeling, and signaling by both G protein-coupled receptors and tyrosine kinase receptors (By similarity). Through Pak activation, may positively regulate microtubule nucleation during interphase. May play a role in the regulation of cytokinesis (By similarity). During embryogenesis, promotes proper muscle morphogenesis and proper guidance and targeting of subsets of myotubes (PubMed:18996366). Required for the recruitment of Pak to muscle attachments in the embryo, probably indirectly through pix/dPIX (PubMed:18996366). May be important for brain development (PubMed:25792865)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9V5N5", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005925 focal adhesion;GO:0030027 lamellipodium", "go_biological_process": "GO:0007525 somatic muscle development;GO:0046621 negative regulation of organ growth;GO:0099504 synaptic vesicle cycle;GO:0007420 brain development;GO:0036465 synaptic vesicle recycling", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q95RG8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q95RX5-1", "uniprot_id": [ { "id": "KCMF1_DROME", "url": "https://www.uniprot.org/uniprot/Q95RX5", "type": "external" } ], "mass": 62398.0, "length": 599, "protein_name": "E3 ubiquitin-protein ligase Kcmf1", "gene_name": "Kcmf1", "organism": "Fruit fly", "refseq_name": "potassium channel modulatory factor 1, isoform E", "refseq_ac": [ { "id": "NP_001163560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163560", "type": "external" } ], "gene_names_uniprotkb": "Kcmf1; CG11984", "gene_names_refseq": "CG11984; Dmel\\CG11984; KCMF1; Kcmf1; kcmf1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Kcmf1; 2.3.2.27", "protein_names_refseq": "CG11984-PE; Kcmf1-PE; potassium channel modulatory factor 1, isoform E; potassium channel modulatory factor 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11984); (R-DME-6798695)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;27552662;40245499", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (By similarity). Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the E2 enzyme Unc6 and the putative E3 ligases poe and Ufd4 to mediate the ubiquitination and proteasomal degradation of rl/MAPK (PubMed:27552662)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q0KI99", "ec_number_list": [ { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "5.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.-", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "5.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0099536 synaptic signaling", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q95RX5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q960C5-1", "uniprot_id": [ { "id": "LRCH_DROME", "url": "https://www.uniprot.org/uniprot/Q960C5", "type": "external" } ], "mass": 87106.0, "length": 809, "protein_name": "Leucine-rich repeat and calponin homology domain-containing protein", "gene_name": "Lrch", "organism": "Fruit fly", "refseq_name": "Leucine-rich-repeats and calponin homology domain protein, isoform A", "refseq_ac": [ { "id": "NP_724046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724046", "type": "external" } ], "gene_names_uniprotkb": "Lrch; CG6860; CT21229; Dmel\\CG6860; Dmel_CG6860; dLRCH", "gene_names_refseq": "CG6860; CT21229; Dmel\\CG6860; Lrch; dLRCH", "protein_names_uniprotkb": "Leucine-rich repeat and calponin homology domain-containing protein; dLRCH", "protein_names_refseq": "CG6860-PA; Leucine-rich-repeats and calponin homology domain protein, isoform A; Lrch-PA", "tax_id": 7227, "disease": "multiple sclerosis (Disease Ontology:DOID:2377)", "pathway": " (dme:Dmel_CG6860); (R-DME-6803207)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;20805893;25589440;26109356;26109357;40245499", "class_list": "", "function": "May play a role in the stabilization of the actin-rich cell cortex during cell division., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 4, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 4, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 4, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005938 cell cortex;GO:0032154 cleavage furrow", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 2.0, "record_id": "Q960C5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q960X8-1", "uniprot_id": [ { "id": "HRS_DROME", "url": "https://www.uniprot.org/uniprot/Q960X8", "type": "external" } ], "mass": 85415.0, "length": 760, "protein_name": "Hepatocyte growth factor-regulated tyrosine kinase substrate", "gene_name": "Hrs", "organism": "Fruit fly", "refseq_name": "hepatocyte growth factor regulated tyrosine kinase substrate, isoform B", "refseq_ac": [ { "id": "NP_525099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525099", "type": "external" } ], "gene_names_uniprotkb": "Hrs; CG2903", "gene_names_refseq": "CG2903; DmHRS; Dmel\\CG2903; HRS-2; HRS; Hrs; Vps27; dHrs; hrs; l(2)23AB5; l(2)23Ad(Hrs); l(2)23Ad; vps27", "protein_names_uniprotkb": "Hepatocyte growth factor-regulated tyrosine kinase substrate", "protein_names_refseq": "CG2903-PB; F[[1]]F[[0]] ATPase; HGF-regulated tyrosine kinase substrate; Hrs-PB; hepatocyte growth factor regulated tyrosine kinase substrate, isoform B; hepatocyte growth factor regulated tyrosine kinase; hepatocyte growth factor-regulated tyrosine kinase substrate; hepatocyte growth factor-regulated tyrosine substrate; hepatocyte growth-factor-regulated substrate", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2903); (R-DME-182971); (R-DME-432720); (R-DME-5689880); (R-DME-8856825); (R-DME-8856828); (R-DME-9013420); (R-DME-917729)", "pathway_count": 8, "publication_count": 6, "publication_id_list": "10693761;10731132;11832215;12537569;12537572;18327897", "class_list": "", "function": "Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4V018;Q8IGU6;Q9VQF2;Q9VQF3", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0035091 phosphatidylinositol binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005938 cell cortex;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:1990182 exosomal secretion;GO:0006897 endocytosis;GO:0016322 neuron remodeling", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q960X8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q967D7-2", "uniprot_id": [ { "id": "TUTL_DROME", "url": "https://www.uniprot.org/uniprot/Q967D7", "type": "external" } ], "mass": 168217.0, "length": 1508, "protein_name": "Protein turtle", "gene_name": "tutl", "organism": "Fruit fly", "refseq_name": "turtle, isoform G", "refseq_ac": [ { "id": "NP_001162869", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162869", "type": "external" } ], "gene_names_uniprotkb": "tutl; CG15427", "gene_names_refseq": "CG15426; CG15427; CG15428; CT35489; CT35490; Dmel\\CG15427; Tutl; jf4; l(2)01085; l(2)24Df; l(2)jf4; mdcds_7441; tutl", "protein_names_uniprotkb": "Protein turtle", "protein_names_refseq": "CG15427-PG; lethal(2)24Df; turtle, isoform G; turtle; tutl-PG", "tax_id": 7227, "disease": "depressive disorder (Disease Ontology:DOID:1596)", "pathway": " (dme:Dmel_CG15427); (R-DME-1474228); (R-DME-210991); (R-DME-216083); (R-DME-428542); (R-DME-433692); (R-DME-9749641)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "10731132;11312296;12537572;24174674", "class_list": "", "function": "Essential protein that plays a role in the establishment of coordinated motor control (PubMed:11312296). In the developing eye, involved in axonal targeting of the R7 photoreceptor (PubMed:24174674)., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "E1JHS9;Q6NR34;Q8IQ17;Q967D8;Q967D9;Q967E0;Q9VQY0;Q9VQY1;Q9VQY2", "ec_number_list": [], "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0007638 mechanosensory behavior;GO:0008344 adult locomotory behavior;GO:0016199 axon midline choice point recognition;GO:0048814 regulation of dendrite morphogenesis;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q967D7-2", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9BIR7-1", "uniprot_id": [ { "id": "HSP75_DROME", "url": "https://www.uniprot.org/uniprot/Q9BIR7", "type": "external" } ], "mass": 70195.0, "length": 641, "protein_name": "Major heat shock 70 kDa protein Bc", "gene_name": "Hsp70Bc", "organism": "Fruit fly", "refseq_name": "heat shock protein 70 Bc", "refseq_ac": [ { "id": "NP_650209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650209", "type": "external" } ], "gene_names_uniprotkb": "Hsp70Bc; CG6489", "gene_names_refseq": "Bc; CG6489; Dm-hsp70; Dmel\\CG6489; HSP70Bc; HSP70cA6; HSP70; Hsp 70; Hsp-70Bc; Hsp-70; Hsp70(87C); Hsp70-BC; Hsp70A7d; Hsp70Bbc; Hsp70Bc; Hsp70Bd; Hsp70B; Hsp70bc; Hsp70; dHsp70; dhsp70; hsp-70; hsp70 87C; hsp70Bc; hsp70B; hsp70", "protein_names_uniprotkb": "Major heat shock 70 kDa protein Bc; HSP70-87C1; Heat shock protein 70Bc", "protein_names_refseq": "70 kDa heat shock protein, cytosolic A 6; 87C locus; CG6489-PA; Heat-shock-protein-70Bc; Hsp70Bc-PA; heat shock 70; heat shock protein 70 Bc; heat shock protein 70; heat-shock protein 70; heat-shock-protein 70bc", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31359); (dme:Dmel_CG6489)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10731132;11493638;11965431;12537572;18344983;6777045", "class_list": "", "function": "Stress-response chaperone protein that prevents toxic aggregation of proteins., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P02824;Q53XF0;Q9BIR8;Q9BIR9;Q9BIS0;Q9I7J6", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0001666 response to hypoxia;GO:0009636 response to toxic substance;GO:0009408 response to heat;GO:0042026 protein refolding;GO:0006986 response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9BIR7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9I7K5-1", "uniprot_id": [ { "id": "TMEDE_DROME", "url": "https://www.uniprot.org/uniprot/Q9I7K5", "type": "external" } ], "mass": 25159.0, "length": 216, "protein_name": "Transmembrane emp24 domain-containing protein eca", "gene_name": "eca", "organism": "Fruit fly", "refseq_name": "eclair", "refseq_ac": [ { "id": "NP_788616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788616", "type": "external" } ], "gene_names_uniprotkb": "eca; CG33104", "gene_names_refseq": "CG33104; CG9443; Dmel\\CG33104; ECA; Eca; eca; p24", "protein_names_uniprotkb": "Transmembrane emp24 domain-containing protein eca; Protein eclair", "protein_names_refseq": "CG33104-PA; eca-PA; eclair", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33104); (R-DME-6807878); (R-DME-6811434)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;15327786;21383842", "class_list": "", "function": "Eca and bai are essential, though not redundant, for dorsoventral patterning of the embryo. Specifically required during early embryogenesis for the activity of maternal tkv, while the zygotic tkv is not affected. Involved in Golgi organization., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q961C1", "ec_number_list": [], "go_molecular_function": "GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0009953 dorsal/ventral pattern formation;GO:0007030 Golgi organization;GO:0048193 Golgi vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9I7K5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9I7K6-1", "uniprot_id": [ { "id": "NASP_DROME", "url": "https://www.uniprot.org/uniprot/Q9I7K6", "type": "external" } ], "mass": 51890.0, "length": 492, "protein_name": "Nuclear autoantigenic sperm protein homolog", "gene_name": "Nasp", "organism": "Fruit fly", "refseq_name": "nuclear autoantigenic sperm protein, isoform B", "refseq_ac": [ { "id": "NP_001246993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246993", "type": "external" } ], "gene_names_uniprotkb": "Nasp; CG8223", "gene_names_refseq": "CG8223; Dmel\\CG8223; FBgn0037624; NASP; Nasp", "protein_names_uniprotkb": "Nuclear autoantigenic sperm protein homolog", "protein_names_refseq": "CG8223-PB; Nasp-PB; nuclear autoantigenic sperm protein, isoform B", "tax_id": 7227, "disease": "ovarian cancer (Disease Ontology:DOID:2394)", "pathway": " (dme:Dmel_CG8223)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;17372656;18327897;36930688", "class_list": "", "function": "Component of the histone chaperone network (PubMed:36930688). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (PubMed:36930688). May also bind and stabilize monomeric H3 (PubMed:36930688). Maternal effect gene essential for early embryogenesis (PubMed:36930688)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A126BEE6", "ec_number_list": [], "go_molecular_function": "GO:0042393 histone binding;GO:0140713 histone chaperone activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0050821 protein stabilization;GO:0006335 DNA replication-dependent chromatin assembly;GO:0034080 CENP-A containing chromatin assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9I7K6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9I7S6-1", "uniprot_id": [ { "id": "PDE9A_DROME", "url": "https://www.uniprot.org/uniprot/Q9I7S6", "type": "external" } ], "mass": 162819.0, "length": 1526, "protein_name": "High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A", "gene_name": "Pde9", "organism": "Fruit fly", "refseq_name": "phosphodiesterase 9, isoform E", "refseq_ac": [ { "id": "NP_001259495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259495", "type": "external" } ], "gene_names_uniprotkb": "Pde9; CG1627; CG32648; CG3754; CG3761; CG3765; CG42276; Dmel\\CG42276; Dmel_CG42276; PDE9", "gene_names_refseq": "CG1627; CG32648; CG3754; CG3761; CG3765; CG42276; Dmel\\CG42276; PDE9; Pde9", "protein_names_uniprotkb": "High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; 3.1.4.35; Phosphodiesterase 9", "protein_names_refseq": "CG42276-PE; Pde9-PE; phosphodiesterase 9, isoform E", "tax_id": 7227, "disease": "Huntington's disease (Disease Ontology:DOID:12858); dilated cardiomyopathy (Disease Ontology:DOID:12930); congestive heart failure (Disease Ontology:DOID:6000)", "pathway": " (dme:Dmel_CG42276)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;15673286;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction;GO:0009187 cyclic nucleotide metabolic process;GO:0046069 cGMP catabolic process;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9I7S6-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9I7T7-1", "uniprot_id": [ { "id": "LAR4_DROME", "url": "https://www.uniprot.org/uniprot/Q9I7T7", "type": "external" } ], "mass": 161994.0, "length": 1531, "protein_name": "La-related protein Larp4B", "gene_name": "Larp4B", "organism": "Fruit fly", "refseq_name": "La-related protein 4B, isoform B", "refseq_ac": [ { "id": "NP_647793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647793", "type": "external" } ], "gene_names_uniprotkb": "Larp4B; CG11505", "gene_names_refseq": "CG11505; Dmel\\CG11505; Larp4B; larp4B", "protein_names_uniprotkb": "La-related protein Larp4B; La ribonucleoprotein domain family member Larp4B", "protein_names_refseq": "CG11505-PB; La-related protein 4B, isoform B; Larp4B-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11505)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;12537572;17372656;18327897;29462618;33925313;40245499", "class_list": "", "function": "Probable RNA binding protein. Negatively regulates myc at the protein level, via an unknown mechanism, and may therefore have a role in growth. Has no effect on myc mRNA levels., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 12, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 12, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 12, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "A0A0H4YFU3;Q7KV72;Q7YTX9;Q9VZS2", "ec_number_list": [], "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0030308 negative regulation of cell growth;GO:0017148 negative regulation of translation;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 2.1, "record_id": "Q9I7T7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9N658-1", "uniprot_id": [ { "id": "GFI1_DROME", "url": "https://www.uniprot.org/uniprot/Q9N658", "type": "external" } ], "mass": 61306.0, "length": 541, "protein_name": "Zinc finger protein sens", "gene_name": "sens", "organism": "Fruit fly", "refseq_name": "senseless", "refseq_ac": [ { "id": "NP_524818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524818", "type": "external" } ], "gene_names_uniprotkb": "sens; CG32120; Lyra", "gene_names_refseq": "1228/04; CG10714; CG32120; Dmel\\CG32120; Gfi1; Ly-1; Ly; SENS; Senseless; Sens; Sen; Ss; l(3)70Ad; sense; sens; sen", "protein_names_uniprotkb": "Zinc finger protein sens; Protein senseless", "protein_names_refseq": "CG32120-PA; lyra; sens-PA; senseless; sensesless; sensless", "tax_id": 7227, "disease": "alcohol use disorder (Disease Ontology:DOID:1574)", "pathway": " (dme:Dmel_CG32120)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;10975525;11709152;12537572;12782275", "class_list": "", "function": "Transcription factor both necessary and sufficient for proper development of most cell types of the embryonic and adult peripheral nervous system (PNS). Essential component of the proneural Notch signaling pathway required for proper sensory organ precursor (SOP) differentiation. Correct expression requires expression of scalloped (sd). Repression of rough (ro) in R8 photoreceptor is an essential mechanism of R8 cell fate determination., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V6Z2", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9N658-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9NEF6-1", "uniprot_id": [ { "id": "VATD2_DROME", "url": "https://www.uniprot.org/uniprot/Q9NEF6", "type": "external" } ], "mass": 28138.0, "length": 249, "protein_name": "V-type proton ATPase subunit D 2", "gene_name": "Vha36-3", "organism": "Fruit fly", "refseq_name": "vacuolar H[+] ATPase 36kD subunit 3, isoform C", "refseq_ac": [ { "id": "NP_001284828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284828", "type": "external" } ], "gene_names_uniprotkb": "Vha36-3; CG8310; Dmel\\CG8310; Dmel_CG8310; EG:BACR25B3.4; vha36-3", "gene_names_refseq": "CG8310; Dmel\\CG8310; EG:BACR25B3.4; Vha36-3; vha36-3", "protein_names_uniprotkb": "V-type proton ATPase subunit D 2; V-ATPase subunit D 2; Vacuolar H+ ATPase subunit 36-3; Vacuolar proton pump subunit D 2", "protein_names_refseq": "CG8310-PC; Vha36-3-PC; vacuolar H[+] ATPase 36kD subunit 3, isoform C; vacuolar H[+] ATPase subunit 36-3", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8310)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;10731137;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9I7X1", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0033176 proton-transporting V-type ATPase complex", "go_biological_process": "GO:0007035 vacuolar acidification;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9NEF6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9NG98-1", "uniprot_id": [ { "id": "TOP3A_DROME", "url": "https://www.uniprot.org/uniprot/Q9NG98", "type": "external" } ], "mass": 136137.0, "length": 1250, "protein_name": "DNA topoisomerase 3-alpha", "gene_name": "Top3alpha", "organism": "Fruit fly", "refseq_name": "topoisomerase 3alpha", "refseq_ac": [ { "id": "NP_523602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523602", "type": "external" } ], "gene_names_uniprotkb": "Top3alpha; CG10123", "gene_names_refseq": "CG10123; DmTop3alpha; Dmel\\CG10123; Top3alpha; Top3a; Topo IIIalpha; dTopoIIIa; top3alpha; top3a; topo IIIalpha", "protein_names_uniprotkb": "DNA topoisomerase 3-alpha; 5.6.2.1; DNA topoisomerase III alpha", "protein_names_refseq": "CG10123-PA; Top 3alpha; Top3alpha-PA; Topoisomerase3alpha; topoisomerase 3-alpha; topoisomerase 3alpha; topoisomerase IIIalpha; topoisomerase IIIa", "tax_id": 7227, "disease": "autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 5 (Disease Ontology:DOID:0111524)", "pathway": " (dme:Dmel_CG10123)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Weakly relaxes negative supercoils and displays a distinct preference for binding single-stranded DNA., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6AWG6;Q9VIV1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity;GO:0003916 DNA topoisomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0042645 mitochondrial nucleoid;GO:0031422 RecQ family helicase-topoisomerase III complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0000724 double-strand break repair via homologous recombination;GO:0006265 DNA topological change;GO:0006264 mitochondrial DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9NG98-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9NI63-1", "uniprot_id": [ { "id": "PMYT1_DROME", "url": "https://www.uniprot.org/uniprot/Q9NI63", "type": "external" } ], "mass": 61131.0, "length": 533, "protein_name": "Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase", "gene_name": "Myt1", "organism": "Fruit fly", "refseq_name": "Myt1", "refseq_ac": [ { "id": "NP_647987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647987", "type": "external" } ], "gene_names_uniprotkb": "Myt1; CG32417", "gene_names_refseq": "CG10569; CG32417; Dmel\\CG32417; Dmyt1; MYT 1; MYT1; Myt1; Myt; dMyt1; myt1", "protein_names_uniprotkb": "Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; 2.7.11.1; Myt1 kinase; dMyt1", "protein_names_refseq": "CG32417-PA; Myt1-PA; Myt1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32417); (R-DME-156711); (R-DME-69273); (R-DME-69478)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "10731132;11882391;12072468;12537569;12537572;15581871;18327897", "class_list": "", "function": "Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of Cdk1 specifically when Cdk1 is complexed to cyclins (PubMed:11882391, PubMed:12072468, PubMed:15581871). Mediates phosphorylation of Cdk1 predominantly on 'Thr-14' (PubMed:11882391). Also involved in Golgi fragmentation (PubMed:11882391). May be involved in phosphorylation of Cdk1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:11882391). May be a downstream target of Notch signaling pathway during eye development (PubMed:12072468)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q961T4;Q9VRP6", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004712 protein serine/threonine/tyrosine kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0000086 G2/M transition of mitotic cell cycle;GO:0045930 negative regulation of mitotic cell cycle;GO:0007143 female meiotic nuclear division;GO:0045793 positive regulation of cell size", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9NI63-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9U3Z7-1", "uniprot_id": [ { "id": "NH2L1_DROME", "url": "https://www.uniprot.org/uniprot/Q9U3Z7", "type": "external" } ], "mass": 13883.0, "length": 127, "protein_name": "NHP2-like protein 1 homolog", "gene_name": "hoip", "organism": "Fruit fly", "refseq_name": "hoi-polloi, isoform B", "refseq_ac": [ { "id": "NP_001260293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260293", "type": "external" } ], "gene_names_uniprotkb": "hoip; CG3949", "gene_names_refseq": "CG3949; Dmel\\CG3949; FE3; HOIP; Hoip; hoip; l(2)FE3", "protein_names_uniprotkb": "NHP2-like protein 1 homolog; Protein hoi-polloi", "protein_names_refseq": "CG3949-PB; Hoi polloi; hoi-polloi, isoform B; hoip-PB; lethal (2) FE3", "tax_id": 7227, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dme:Dmel_CG3949); (R-DME-6791226)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VL98", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0071011 precatalytic spliceosome;GO:0031428 box C/D methylation guide snoRNP complex;GO:0030532 small nuclear ribonucleoprotein complex;GO:0046540 U4/U6 x U5 tri-snRNP complex", "go_biological_process": "GO:0010608 post-transcriptional regulation of gene expression;GO:0045727 positive regulation of translation;GO:0000398 mRNA splicing, via spliceosome;GO:0030490 maturation of SSU-rRNA;GO:0060415 muscle tissue morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9U3Z7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9U5V6-1", "uniprot_id": [ { "id": "GDLO_DROME", "url": "https://www.uniprot.org/uniprot/Q9U5V6", "type": "external" } ], "mass": 4203.0, "length": 39, "protein_name": "Gonadal protein gdl-ORF39", "gene_name": "gdl-ORF39", "organism": "Fruit fly", "refseq_name": "gdl-ORF39", "refseq_ac": [ { "id": "NP_001027126", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027126", "type": "external" } ], "gene_names_uniprotkb": "gdl-ORF39; CG33755", "gene_names_refseq": "CG33088; CG33755; CG7268; Dmel\\CG33755; ORF39; gdl-ORF39", "protein_names_uniprotkb": "Gonadal protein gdl-ORF39", "protein_names_refseq": "CG33755-PA; gdl-ORF39-PA; gdl-ORF39", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG33755)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;2117521;2497054", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9U5V6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9U915-1", "uniprot_id": [ { "id": "KAD2_DROME", "url": "https://www.uniprot.org/uniprot/Q9U915", "type": "external" } ], "mass": 26543.0, "length": 240, "protein_name": "Adenylate kinase 2", "gene_name": "Ak2", "organism": "Fruit fly", "refseq_name": "adenylate kinase 2", "refseq_ac": [ { "id": "NP_523836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523836", "type": "external" } ], "gene_names_uniprotkb": "Ak2; Adk2; CG3140; Dak2", "gene_names_refseq": "ADK-2; Adk2-44B; Adk2-60B; Adk2; Ak2; BcDNA:SD09634; CG3140; Dak2; Dmel\\CG3140; anon-Dak2; l(2)04201; l(2)04209; l(2)k04201; l(2)k04209; l(2)k16120", "protein_names_uniprotkb": "Adenylate kinase 2; 2.7.4.3; ATP-AMP transphosphorylase; ATP:AMP phosphotransferase; Adenylate kinase cytosolic and mitochondrial; Adenylate monophosphate kinase", "protein_names_refseq": "Adk2-44B; Adk2-60B; Ak2-PA; CG3140-PA; adenylate kinase 2; adenylate kinase-2", "tax_id": 7227, "disease": "reticular dysgenesis (Disease Ontology:DOID:0060020); temporal lobe epilepsy (Disease Ontology:DOID:3328)", "pathway": " (dme:Dmel_CG3140); (R-DME-499943)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10731132;10786623;12537572;18327897;19416704;24705759", "class_list": "", "function": "Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP (By similarity) (PubMed:19416704). Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways (By similarity). Essential for viability (PubMed:19416704)., [UniProtKB, HAMAP, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9W1D0", "ec_number_list": [ { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0006172 ADP biosynthetic process;GO:0046033 AMP metabolic process;GO:0046034 ATP metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9U915-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9U9P7-1", "uniprot_id": [ { "id": "PITC1_DROME", "url": "https://www.uniprot.org/uniprot/Q9U9P7", "type": "external" } ], "mass": 31730.0, "length": 273, "protein_name": "Cytoplasmic phosphatidylinositol transfer protein 1", "gene_name": "rdgBbeta", "organism": "Fruit fly", "refseq_name": "rdgBbeta", "refseq_ac": [ { "id": "NP_611248", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611248", "type": "external" } ], "gene_names_uniprotkb": "rdgBbeta; CG17818", "gene_names_refseq": "BcDNA.LD14189; BcDNA:LD14189; CG17818; Dmel\\CG17818; DrdgBbeta; RdgB-beta; RdgBbeta; rdgBbeta; rdgbeta", "protein_names_uniprotkb": "Cytoplasmic phosphatidylinositol transfer protein 1; RdgBbeta; Retinal degeneration B homolog beta", "protein_names_refseq": "CG17818-PA; rdgBbeta-PA; rdgBbeta", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17818)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;10731138;12537572", "class_list": "", "function": "Phosphatidylinositol transfer proteins mediate the monomeric transport of lipids by shielding a lipid from the aqueous environment and binding the lipid in a hydrophobic cavity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding;GO:0008526 phosphatidylinositol transfer activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9U9P7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3C5-1", "uniprot_id": [ { "id": "RIC1_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3C5", "type": "external" } ], "mass": 159157.0, "length": 1429, "protein_name": "Guanine nucleotide exchange factor subunit Rich", "gene_name": "Rich", "organism": "Fruit fly", "refseq_name": "RIC1 homolog, isoform B", "refseq_ac": [ { "id": "NP_001262205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262205", "type": "external" } ], "gene_names_uniprotkb": "Rich; CG9063", "gene_names_refseq": "3L6; BcDNA:GH03694; BcDNAGH03694; CG9063; Dmel\\CG9063; Rich; rich", "protein_names_uniprotkb": "Guanine nucleotide exchange factor subunit Rich; Protein RIC1 homolog", "protein_names_refseq": "CG9063-PB; RIC1 homolog, isoform B; Rich-PB; ric1 homologue", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9063); (R-DME-6811440); (R-DME-8876198)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;10731138;12537572;18327897;21835342", "class_list": "", "function": "Probable component of a guanine nucleotide exchange factor (GEF) that may be required for efficient fusion of endosome-derived vesicles with the Golgi (By similarity). Plays a role in regulating Rab6-dependent CadN transport in photoreceptor cells which is required for the formation of normal synaptic connections between axons from the inner photoreceptor cells in the eye and postsynaptic cells in the brain medulla layer M6, and for the generation of normal postsynaptic responses., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "M9PG00", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0034066 Ric1-Rgp1 guanyl-nucleotide exchange factor complex;GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0032483 regulation of Rab protein signal transduction;GO:0006886 intracellular protein transport;GO:0043547 positive regulation of GTPase activity;GO:0050808 synapse organization;GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9V3C5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3D4-1", "uniprot_id": [ { "id": "IDGF2_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3D4", "type": "external" } ], "mass": 49159.0, "length": 440, "protein_name": "Chitinase-like protein Idgf2", "gene_name": "Idgf2", "organism": "Fruit fly", "refseq_name": "imaginal disc growth factor 2, isoform A", "refseq_ac": [ { "id": "NP_477257", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477257", "type": "external" } ], "gene_names_uniprotkb": "Idgf2; CG4475", "gene_names_refseq": "BG:DS02780.4; CG4475; DmIDGF2; Dmel\\CG4475; IDGF-2; IDGF2; IDGF; Idgf2; idgf2; ldgf2", "protein_names_uniprotkb": "Chitinase-like protein Idgf2; Imaginal disk growth factor protein 2", "protein_names_refseq": "CG4475-PA; Idgf2-PA; imaginal disc growth factor 2, isoform A; imaginal disc growth factor 2", "tax_id": 7227, "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); small cell carcinoma (Disease Ontology:DOID:0050685); colorectal carcinoma (Disease Ontology:DOID:0080199); prostate carcinoma (Disease Ontology:DOID:10286); pre-eclampsia (Disease Ontology:DOID:10591); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); temporal arteritis (Disease Ontology:DOID:13375); pulmonary sarcoidosis (Disease Ontology:DOID:13406); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); melanoma (Disease Ontology:DOID:1909); arteriosclerosis (Disease Ontology:DOID:2349); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); ovarian cancer (Disease Ontology:DOID:2394); asthma (Disease Ontology:DOID:2841); glioblastoma (Disease Ontology:DOID:3068); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); chondrosarcoma (Disease Ontology:DOID:3371); coronary artery disease (Disease Ontology:DOID:3393); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); systemic scleroderma (Disease Ontology:DOID:418); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); neuromyelitis optica (Disease Ontology:DOID:8869); acute myeloid leukemia (Disease Ontology:DOID:9119); type 2 diabetes mellitus (Disease Ontology:DOID:9352); bacterial meningitis (Disease Ontology:DOID:9470); multiple myeloma (Disease Ontology:DOID:9538); type 1 diabetes mellitus (Disease Ontology:DOID:9744)", "pathway": " (dme:Dmel_CG4475); (R-DME-189085); (R-DME-6798695)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10471707;10731132;11821393;12537569;12537572;9847235", "class_list": "", "function": "Cooperates with insulin-like peptides to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 32, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O96665", "ec_number_list": [], "go_molecular_function": "GO:0008061 chitin binding;GO:0008084 imaginal disc growth factor receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0005975 carbohydrate metabolic process;GO:0006032 chitin catabolic process;GO:0007444 imaginal disc development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9V3D4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3J3-1", "uniprot_id": [ { "id": "MS57C_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3J3", "type": "external" } ], "mass": 8452.0, "length": 76, "protein_name": "Accessory gland-specific peptide 57Dc", "gene_name": "Mst57Dc", "organism": "Fruit fly", "refseq_name": "Male-specific transcript 57Dc", "refseq_ac": [ { "id": "NP_524498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524498", "type": "external" } ], "gene_names_uniprotkb": "Mst57Dc; CG4986", "gene_names_refseq": "Acp57Dc; CG4986; Dmel\\CG4986; Mst57Dc; Mst75Dc; mst(2)ag-1; mst-1", "protein_names_uniprotkb": "Accessory gland-specific peptide 57Dc; 45 kDa cAMP-dependent phosphoprotein; Male accessory gland secretory protein 57Dc; Pp45", "protein_names_refseq": "CG4986-PB; Male-specific transcript 57Dc; Mst57Dc-PB; Mst57dc for male accessory gland protein; male specific transcript 57D; male-specific RNA 57dc", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4986)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10451922;10731132;12537572;15944345;7711745", "class_list": "", "function": "Transferred from male to female during mating and may affect egglaying and behavior after mating., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24392;Q3HKR0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007320 insemination;GO:0007618 mating;GO:0045924 regulation of female receptivity;GO:0018991 egg-laying behavior", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9V3J3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3Q2-1", "uniprot_id": [ { "id": "OR35A_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3Q2", "type": "external" } ], "mass": 47388.0, "length": 409, "protein_name": "Odorant receptor 35a", "gene_name": "Or35a", "organism": "Fruit fly", "refseq_name": "odorant receptor 35a", "refseq_ac": [ { "id": "NP_723916", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_723916", "type": "external" } ], "gene_names_uniprotkb": "Or35a; CG17868", "gene_names_refseq": "35a; 36E.1; BACR44L22.5; BG:BACR44L22.5; CG17868; DOR91; Dmel\\CG17868; OR35a; Or35a", "protein_names_uniprotkb": "Odorant receptor 35a", "protein_names_refseq": "CG17868-PB; Or35a-PB; odorant receptor 35a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17868)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10471707;10731132;10943836;12537572;16162917;16615896;21613503;21677030;21857978;22038943", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Forms a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to esters. Involved in the behavioral responses to butanol, pentanol, hexanol, octanol, propyl acetate, and butyl acetate., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8IP41", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0099094 ligand-gated monoatomic cation channel activity;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0098655 monoatomic cation transmembrane transport;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9V3Q2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3Q6-1", "uniprot_id": [ { "id": "M3K7_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3Q6", "type": "external" } ], "mass": 75675.0, "length": 678, "protein_name": "Mitogen-activated protein kinase kinase kinase 7", "gene_name": "Tak1", "organism": "Fruit fly", "refseq_name": "TGF-beta activated kinase 1, isoform A", "refseq_ac": [ { "id": "NP_524080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524080", "type": "external" } ], "gene_names_uniprotkb": "Tak1; CG1388; CG18492; D-TAK; D-tak; D10; DTAK1; DTak1; DTak; DmTak1; Dmel\\CG18492; Dmel_CG18492; TAK-1; TAK1; TAK; Tak 1; Tak; dTAK-1; dTAK1; dTAK; dTak1; dTak; dtak1; tak1; tak", "gene_names_refseq": "CG1388; CG18492; D-TAK; D-tak; D10; DTAK1; DTak1; DTak; DmTak1; Dmel\\CG18492; TAK-1; TAK1; TAK; Tak 1; Tak1; Tak; dTAK-1; dTAK1; dTAK; dTak1; dTak; dtak1; tak1; tak", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase 7; 2.7.11.25; TGF-beta-activated kinase 1; dTAK1", "protein_names_refseq": "CG18492-PA; TGF beta-activated kinase 1; TGF-beta activated kinase 1, isoform A; TGF-beta activated-kinase 1; TGFbeta-activated kinase 1; Tak1-PA; transforming growth factor beta-activated kinase; transforming growth factor-beta activated kinase 1; transforming growth factor-beta-activated kinase 1", "tax_id": 7227, "disease": "frontometaphyseal dysplasia (Disease Ontology:DOID:0111785); frontometaphyseal dysplasia 2 (Disease Ontology:DOID:0111787); prostate cancer (Disease Ontology:DOID:10283); benign hypertensive renal disease (Disease Ontology:DOID:11520); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); arteriosclerosis (Disease Ontology:DOID:2349); coronary artery disease (Disease Ontology:DOID:3393); Wolff-Parkinson-White syndrome (Disease Ontology:DOID:384); myocardial infarction (Disease Ontology:DOID:5844); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (dme:Dmel_CG18492); (R-DME-209447); (R-DME-214399); (R-DME-4086398); (R-DME-445989); (R-DME-450302); (R-DME-450321)", "pathway_count": 7, "publication_count": 21, "publication_id_list": "10731132;10757786;11018014;12537568;12537569;12537572;12537573;12537574;12732719;14519762;15037551;16081424;16110336;16311020;16894030;17158449;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Responsible for activation of the JNK MAPK pathway (basket, bsk and hemipterous, hep) in response to LPS. Component of the NF-kappa-B pathway; relish-mediated JNK inhibition involves proteasomal degradation of Tak1; certain targets of Relish that are induced during immune responses may facilitate destruction of Tak1 and switch off the JNK cascade. Participates in diverse roles such as control of cell shape and regulation of apoptosis., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0004709 MAP kinase kinase kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0048749 compound eye development;GO:0006955 immune response;GO:0010506 regulation of autophagy;GO:0010628 positive regulation of gene expression;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 2.2, "record_id": "Q9V3Q6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3W0-1", "uniprot_id": [ { "id": "UK114_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3W0", "type": "external" } ], "mass": 14876.0, "length": 138, "protein_name": "RutC family protein UK114", "gene_name": "UK114", "organism": "Fruit fly", "refseq_name": "UK114, isoform B", "refseq_ac": [ { "id": "NP_001260465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260465", "type": "external" } ], "gene_names_uniprotkb": "UK114; CG15261", "gene_names_refseq": "BG:DS07851.3; BcDNA:GM01181; CG15261; DUK 114; DUK114; Dmel\\CG15261; UK114", "protein_names_uniprotkb": "RutC family protein UK114", "protein_names_refseq": "CG15261-PB; UK114, isoform B; UK114-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15261); (R-DME-8849175)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537572;15250825", "class_list": "", "function": "Molecular chaperone. Seems to fulfill an ATP-independent, HSP70-like function in protein folding. May protect essential factors of cell proliferation during heat shock. No role in calpain activation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019239 deaminase activity;GO:0044183 protein folding chaperone;GO:0120242 2-iminobutanoate deaminase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006457 protein folding;GO:0017148 negative regulation of translation;GO:0006402 mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9V3W0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3W6-1", "uniprot_id": [ { "id": "INX7_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3W6", "type": "external" } ], "mass": 50669.0, "length": 438, "protein_name": "Innexin inx7", "gene_name": "Inx7", "organism": "Fruit fly", "refseq_name": "innexin 7", "refseq_ac": [ { "id": "NP_788872", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788872", "type": "external" } ], "gene_names_uniprotkb": "Inx7; CG2977; prp7", "gene_names_refseq": "CG2977; CG32731; D-inx-7; Dm-inx7; Dmel\\CG2977; FBpp0070994; Inx7; inx-7; inx7; prp7", "protein_names_uniprotkb": "Innexin inx7; Gap junction protein prp7; Innexin-7; Pas-related protein 7", "protein_names_refseq": "CG2977-PA; Inx7-PA; innexin 7; innexin7; pas related protein 7", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2977)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10352230;10731132;12537569;12537572", "class_list": "", "function": "Structural components of the gap junctions., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "C6TP24;Q961J1", "ec_number_list": [], "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005921 gap junction", "go_biological_process": "GO:0034220 monoatomic ion transmembrane transport;GO:0007602 phototransduction;GO:0010496 intercellular transport;GO:0072375 medium-term memory", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9V3W6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V3Z1-1", "uniprot_id": [ { "id": "TRIB_DROME", "url": "https://www.uniprot.org/uniprot/Q9V3Z1", "type": "external" } ], "mass": 54077.0, "length": 484, "protein_name": "Tribbles", "gene_name": "trbl", "organism": "Fruit fly", "refseq_name": "tribbles", "refseq_ac": [ { "id": "NP_524672", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524672", "type": "external" } ], "gene_names_uniprotkb": "trbl; CG5408", "gene_names_refseq": "CG5408; Dmel\\CG5408; Trbl; trbl; trb", "protein_names_uniprotkb": "Tribbles", "protein_names_refseq": "CG5408-PA; trbl-PA; tribbless; tribbles", "tax_id": 7227, "disease": "glucose metabolism disease (Disease Ontology:DOID:4194)", "pathway": " (dme:Dmel_CG5408); (R-DME-1257604); (R-DME-165158); (R-DME-199418); (R-DME-389357); (R-DME-5218920)", "pathway_count": 6, "publication_count": 13, "publication_id_list": "10731132;10837248;10850493;10850494;10949024;12537572;15581871;18430923;23290551;23305818;25329475;28669782;29025897", "class_list": "", "function": "Adapter protein that negatively regulates different signaling pathways to coordinate cell differentiation, proliferation, migration and growth (PubMed:10837248, PubMed:10850493, PubMed:10850494, PubMed:10949024, PubMed:23305818, PubMed:25329475). Functions by binding to key regulatory proteins and either blocks their activity or regulates their turnover by the proteasome (PubMed:10837248, PubMed:10850493, PubMed:10850494, PubMed:10949024, PubMed:23305818, PubMed:25329475). In various developing tissues functions as a cell cycle regulator that mediates cell proliferation according to the requirements of the developmental program (PubMed:10837248, PubMed:10850493, PubMed:10850494, PubMed:15581871). Acts by inducing the proteasomal degradation of the CD25 mitotic activators stg and twe at critical stages of development to delay entry into mitosis and thus mediate cell proliferation (PubMed:10837248, PubMed:10850493, PubMed:10850494, PubMed:15581871, PubMed:23290551, PubMed:29025897). During gastrulation, negatively regulates stg to delay mitosis in the ventral region of the embryonic mesoderm thus allowing invagination to be completed before cell division takes place (PubMed:10837248, PubMed:10850493, PubMed:10850494). Delaying stg-dependent mitosis during bristle development and in migrating germline pole cells also arrests their cell divisions, whereas in cystocytes it promotes their cell divisions (PubMed:10837248, PubMed:10850493, PubMed:15581871). Involved in the regulation of the mid-blastula transition; promotes the destruction of twe resulting in the cell cycle arrest in G2 of cycle 14 which delays mitosis and thus reduces cell proliferation allowing cell fate specification and morphogenesis to take place (PubMed:23290551). In germline cells, blocks border cell migration during oogenesis by binding to slbo/C/EBP and promoting its ubiquitination and degradation by the proteasome (PubMed:10949024, PubMed:23305818, PubMed:29025897). May function in a negative feedback loop with slbo to coordinate proper border cell migration (PubMed:23305818). During tissue growth negatively regulates insulin signaling by binding to Akt1 and blocking its phosphorylation-dependent activation (PubMed:25329475, PubMed:29025897). However it may also function downstream in the insulin signaling pathway, acting with Akt1 to direct foxo degradation (PubMed:25329475). Essential for the proper formation of operant place and aversive olfactory memories (PubMed:18430923, PubMed:28669782)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0031434 mitogen-activated protein kinase kinase binding;GO:0004860 protein kinase inhibitor activity;GO:0030291 protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005938 cell cortex", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0010888 negative regulation of lipid storage;GO:0042593 glucose homeostasis;GO:0045793 positive regulation of cell size;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9V3Z1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V439-1", "uniprot_id": [ { "id": "MED22_DROME", "url": "https://www.uniprot.org/uniprot/Q9V439", "type": "external" } ], "mass": 16594.0, "length": 143, "protein_name": "Mediator of RNA polymerase II transcription subunit 22", "gene_name": "MED22", "organism": "Fruit fly", "refseq_name": "mediator complex subunit 22", "refseq_ac": [ { "id": "NP_569870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569870", "type": "external" } ], "gene_names_uniprotkb": "MED22; CG3034; Med24", "gene_names_refseq": "144358_at; CG18830; CG3034; Dmel\\CG3034; EG:BACR7A4.6; MED22; Med22; Med24; Srb6/Surf5; anon-EST:Liang-1.82; clone 1.82; dMED24; med22", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 22; Mediator complex subunit 22; dMED24", "protein_names_refseq": "CG3034-PA; MED22-PA; mediator complex subunit 22", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3034)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;10731137;12021283;12537569;12537572", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000785 chromatin;GO:0016592 mediator complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9V439-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V447-1", "uniprot_id": [ { "id": "KRH2_DROME", "url": "https://www.uniprot.org/uniprot/Q9V447", "type": "external" } ], "mass": 31215.0, "length": 276, "protein_name": "Krueppel homolog 2", "gene_name": "Kr-h2", "organism": "Fruit fly", "refseq_name": "kruppel homolog 2, isoform B", "refseq_ac": [ { "id": "NP_001162894", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162894", "type": "external" } ], "gene_names_uniprotkb": "Kr-h2; CG9159; Dmel\\CG9159; Dmel_CG9159; Kr-H2; Kr-h; anon-26Ba", "gene_names_refseq": "CG9159; Dmel\\CG9159; Kr-H2; Kr-h2; Kr-h; anon-26Ba", "protein_names_uniprotkb": "Krueppel homolog 2; Protein Kr-h2", "protein_names_refseq": "CG9159-PB; Kr-h2-PB; anon-26Ba; kruppel homolog 2, isoform B; kruppel homolog", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9159)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "10731132;10816971;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Member of the dosage-dependent hierarchy effective upon white gene expression., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C0PV57;E1JHA1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:0061024 membrane organization", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9V447-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V466-1", "uniprot_id": [ { "id": "NU107_DROME", "url": "https://www.uniprot.org/uniprot/Q9V466", "type": "external" } ], "mass": 97382.0, "length": 845, "protein_name": "Nuclear pore complex protein Nup107", "gene_name": "Nup107", "organism": "Fruit fly", "refseq_name": "nucleoporin 107kD", "refseq_ac": [ { "id": "NP_609446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609446", "type": "external" } ], "gene_names_uniprotkb": "Nup107; CG6743", "gene_names_refseq": "BcDNA:LD18761; CG6743; Dmel\\CG6743; Nup 107; Nup107; Nup170; Nup; dmNup107; nup107", "protein_names_uniprotkb": "Nuclear pore complex protein Nup107; Nucleoporin Nup107", "protein_names_refseq": "CG6743-PA; Nup107-PA; Nup170; nucleoporin 107kD; nucleoporin 107", "tax_id": 7227, "disease": "nephrotic syndrome type 11 (Disease Ontology:DOID:0080385); ovarian dysgenesis 6 (Disease Ontology:DOID:0080498); Galloway-Mowat syndrome (Disease Ontology:DOID:0080694); 46 XX gonadal dysgenesis (Disease Ontology:DOID:14450)", "pathway": " (dme:Dmel_CG6743); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236); (R-DME-1855170); (R-DME-1855196); (R-DME-1855229); (R-DME-3108214); (R-DME-3301854); (R-DME-3371453); (R-DME-4085377); (R-DME-4551638); (R-DME-4615885); (R-DME-9615933)", "pathway_count": 15, "publication_count": 10, "publication_id_list": "10731132;10731138;12537572;18562695;20547758;26485283;26502056;27402967;31626769;31784359", "class_list": "", "function": "Plays a role in nuclear pore complex (NPC) assembly and maintenance (PubMed:20547758). Required for nuclear import of Mad (PubMed:20547758). Mediates the association between the nuclear pore complex and a subset of active chromatin regions adjacent to lamin-associated domains (PubMed:31784359). Plays a role in double strand break repair by relocalizing the heterochromatic double strand breaks (DSBs) to the nuclear periphery as part of the homologous recombination (HR) repair process (PubMed:26502056). Regulates cytokinesis during spermatocyte meiosis by maintaining type-B lamin Lam localization to the spindle envelope (PubMed:27402967). Regulates female gonad development and oogenesis (PubMed:26485283)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0031080 nuclear pore outer ring;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005819 spindle;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006281 DNA repair;GO:0006406 mRNA export from nucleus;GO:0006913 nucleocytoplasmic transport;GO:0046822 regulation of nucleocytoplasmic transport;GO:0008585 female gonad development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9V466-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V468-1", "uniprot_id": [ { "id": "Y9776_DROME", "url": "https://www.uniprot.org/uniprot/Q9V468", "type": "external" } ], "mass": 140295.0, "length": 1260, "protein_name": "Zinc finger matrin-type protein CG9776", "gene_name": "CG9776", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": [ { "id": "NP_649455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649455", "type": "external" } ], "gene_names_uniprotkb": "CG9776", "gene_names_refseq": "BcDNA:LD19168; CG9776; Dmel\\CG9776", "protein_names_uniprotkb": "Zinc finger matrin-type protein CG9776", "protein_names_refseq": "CG9776-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9776)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;10731138;12537569;12537572;17372656;18327897", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q7JRP8;Q8I092", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9V468-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V492-1", "uniprot_id": [ { "id": "MPV17_DROME", "url": "https://www.uniprot.org/uniprot/Q9V492", "type": "external" } ], "mass": 19521.0, "length": 168, "protein_name": "Mitochondrial inner membrane protein Mpv17", "gene_name": "Mpv17", "organism": "Fruit fly", "refseq_name": "mitochondrial inner membrane protein MPV17", "refseq_ac": [ { "id": "NP_651944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651944", "type": "external" } ], "gene_names_uniprotkb": "Mpv17; CG11077", "gene_names_refseq": "CG11077; Dmel\\CG11077; MPV17; Mpv17; PMP22; dMpv17", "protein_names_uniprotkb": "Mitochondrial inner membrane protein Mpv17; Mpv17-like protein; dMpv17", "protein_names_refseq": "CG11077-PA; Mpv17-PA; mitochondrial inner membrane protein MPV17", "tax_id": 7227, "disease": "mitochondrial DNA depletion syndrome (Disease Ontology:DOID:0070329); mitochondrial DNA depletion syndrome 3 (Disease Ontology:DOID:0080121); mitochondrial DNA depletion syndrome 6 (Disease Ontology:DOID:0080125); Alport syndrome 2 (Disease Ontology:DOID:0110033); Charcot-Marie-Tooth disease type 2EE (Disease Ontology:DOID:0111559); nephrotic syndrome (Disease Ontology:DOID:1184); mitochondrial metabolism disease (Disease Ontology:DOID:700)", "pathway": " (dme:Dmel_CG11077); (R-DME-9033241)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;36587049;37810222", "class_list": "", "function": "Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis (PubMed:37810222). Can translocate uridine, but not orotate, across a lipid membrane (PubMed:37810222). Involved in maintenance of mitochondrial ultrastructure (PubMed:37810222). May be involved in mitochondrial DNA (mtDNA) maintenance but does not appear to be directly involved in mitochondrial deoxynucleoside triphosphate (dNTP) pool homeostasis (PubMed:37810222). May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation (PubMed:36587049)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015213 uridine transmembrane transporter activity;GO:0005216 monoatomic ion channel activity;GO:0015267 channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0015862 uridine transmembrane transport;GO:0034220 monoatomic ion transmembrane transport;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9V492-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V4F9-1", "uniprot_id": [ { "id": "MED26_DROME", "url": "https://www.uniprot.org/uniprot/Q9V4F9", "type": "external" } ], "mass": 165516.0, "length": 1483, "protein_name": "Mediator of RNA polymerase II transcription subunit 26", "gene_name": "MED26", "organism": "Fruit fly", "refseq_name": "mediator complex subunit 26, isoform A", "refseq_ac": [ { "id": "NP_651936", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651936", "type": "external" } ], "gene_names_uniprotkb": "MED26; Arc70; CG1793; CG1823", "gene_names_refseq": "ARC 70; Arc70; CG1793; CG1823; Dmel\\CG1793; MED26; Med26; dARC70; med26", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 26; Mediator complex subunit 26; dARC70", "protein_names_refseq": "CG1793-PA; MED26-PA; mediator complex subunit 26, isoform A; mediator subunit 26", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1793)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;16751183;18327897;40245499", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA gene., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6AWG8;Q86P16;Q8SX84", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000785 chromatin;GO:0005721 pericentric heterochromatin;GO:0016592 mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9V4F9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V4Z9-1", "uniprot_id": [ { "id": "LINES_DROME", "url": "https://www.uniprot.org/uniprot/Q9V4Z9", "type": "external" } ], "mass": 96292.0, "length": 858, "protein_name": "Protein lines", "gene_name": "lin", "organism": "Fruit fly", "refseq_name": "lines", "refseq_ac": [ { "id": "NP_524815", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524815", "type": "external" } ], "gene_names_uniprotkb": "lin; CG11770", "gene_names_refseq": "CG11770; Dmel\\CG11770; Lin; lin", "protein_names_uniprotkb": "Protein lines", "protein_names_refseq": "CG11770-PA; lin-PA; lines", "tax_id": 7227, "disease": "autosomal recessive intellectual developmental disorder 27 (Disease Ontology:DOID:0081193)", "pathway": " (dme:Dmel_CG11770)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;10837029;11784087;12117814;12537572;14568103;8620835;9477325", "class_list": "", "function": "Has a dual role as a segment polarity protein and as a modulator of the Abd-B protein. Required for Abd-B to activate the transcription of genes (including ems, cut and sal) that are involved in posterior spiracle morphogenesis. Also required for Abd-B to form an eighth abdominal denticle belt. Acts in a hierarchy downstream of drm and upstream of bowl during foregut and hindgut patterning and morphogenesis. Involved in cell rearrangement during elongation of the embryonic hindgut. Required to regulate expression of embryonic hindgut patterning genes in order to establish the large intestine and at least some rectum, and to repress small intestine fate. Required for late wingless (wg)-dependent cell fate specification in the dorsal embryonic epidermis. Acts in concert with wg to regulate expression of wg itself and also to regulate wg-target genes. May have a role in ventral epidermal patterning, independent of wg signaling., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0048619 embryonic hindgut morphogenesis;GO:0007442 hindgut morphogenesis;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008544 epidermis development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9V4Z9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V521-1", "uniprot_id": [ { "id": "PPO2_DROME", "url": "https://www.uniprot.org/uniprot/Q9V521", "type": "external" } ], "mass": 79285.0, "length": 684, "protein_name": "Phenoloxidase 2", "gene_name": "PPO2", "organism": "Fruit fly", "refseq_name": "prophenoloxidase 2", "refseq_ac": [ { "id": "NP_610443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610443", "type": "external" } ], "gene_names_uniprotkb": "PPO2; CG8193; proPO45; proPo-A3", "gene_names_refseq": "CG8193; DmePPO2; Dmel\\CG8193; PO45; PPO2; PPO; Ppo2; ProPO45; ppo2; proPO45; proPOA(3); proPo-A3", "protein_names_uniprotkb": "Phenoloxidase 2; 1.14.18.1; PO A3; Phenoloxidase subunit A3; Pro-phenoloxidase A3; Processed phenoloxidase A3", "protein_names_refseq": "CG8193-PA; PPO2-PA; phenoloxidase A3; phenoloxidase subunit A3; prophenoloxidase 2; prophenoloxidase 45", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8193)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;12834045;19141111", "class_list": "", "function": "This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6 dihydroxyindole to indole-5'6 quinonee (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9BLD9", "ec_number_list": [ { "id": "1.14.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.18.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004503 tyrosinase activity;GO:0004097 catechol oxidase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol", "go_biological_process": "GO:0050830 defense response to Gram-positive bacterium;GO:0042417 dopamine metabolic process;GO:0042438 melanin biosynthetic process;GO:0050832 defense response to fungus;GO:0035006 melanization defense response", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9V521-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V5P6-1", "uniprot_id": [ { "id": "NOP10_DROME", "url": "https://www.uniprot.org/uniprot/Q9V5P6", "type": "external" } ], "mass": 7634.0, "length": 64, "protein_name": "H/ACA ribonucleoprotein complex subunit 3", "gene_name": "Nop10", "organism": "Fruit fly", "refseq_name": "Nop10 ribonucleoprotein", "refseq_ac": [ { "id": "NP_610610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610610", "type": "external" } ], "gene_names_uniprotkb": "Nop10; CG7637", "gene_names_refseq": "CG7637; Dmel\\CG7637; NOP10; Nop10", "protein_names_uniprotkb": "H/ACA ribonucleoprotein complex subunit 3; Nucleolar protein 10; Nucleolar protein family A member 3; Ribonucleoprotein Nop10; snoRNP protein dNop10", "protein_names_refseq": "CG7637-PA; Nop10 ribonucleoprotein; Nop10-PA", "tax_id": 7227, "disease": "autosomal recessive dyskeratosis congenita 1 (Disease Ontology:DOID:0070015); dyskeratosis congenita (Disease Ontology:DOID:2729)", "pathway": " (dme:Dmel_CG7637)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12426388;12537572;37343092", "class_list": "", "function": "Component of the box H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:37343092). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (Probable). Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (Probable). Required for ribosome biogenesis (PubMed:37343092). H/ACA snoRNP complex-dependent ribosome biogenesis is important in female germline cell differentiation during oogenesis (PubMed:37343092)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4QPR2", "ec_number_list": [], "go_molecular_function": "GO:0030515 snoRNA binding;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0031429 box H/ACA snoRNP complex", "go_biological_process": "GO:0042254 ribosome biogenesis;GO:0031118 rRNA pseudouridine synthesis;GO:0031120 snRNA pseudouridine synthesis;GO:0000454 snoRNA guided rRNA pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9V5P6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V6A9-1", "uniprot_id": [ { "id": "OR49A_DROME", "url": "https://www.uniprot.org/uniprot/Q9V6A9", "type": "external" } ], "mass": 46463.0, "length": 396, "protein_name": "Odorant receptor 49a", "gene_name": "Or49a", "organism": "Fruit fly", "refseq_name": "odorant receptor 49a", "refseq_ac": [ { "id": "NP_523711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523711", "type": "external" } ], "gene_names_uniprotkb": "Or49a; CG13158", "gene_names_refseq": "49A.1; 49a; CG13158; DOR10; DmOr49a; Dmel\\CG13158; OR49a; Or49a", "protein_names_uniprotkb": "Odorant receptor 49a", "protein_names_refseq": "CG13158-PA; Or49a-PA; odorant receptor 49a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13158)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;21613503;21857978", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to butanol and 2-heptanone., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0042048 olfactory behavior;GO:0007165 signal transduction;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9V6A9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V6H2-1", "uniprot_id": [ { "id": "OR49B_DROME", "url": "https://www.uniprot.org/uniprot/Q9V6H2", "type": "external" } ], "mass": 43899.0, "length": 375, "protein_name": "Odorant receptor 49b", "gene_name": "Or49b", "organism": "Fruit fly", "refseq_name": "odorant receptor 49b", "refseq_ac": [ { "id": "NP_523721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523721", "type": "external" } ], "gene_names_uniprotkb": "Or49b; AN13; CG17584", "gene_names_refseq": "49D.1; 49b; AN13; CG17584; DOR105; DmOr49b; Dmel\\CG17584; OR49b; Or-49b; Or49b", "protein_names_uniprotkb": "Odorant receptor 49b", "protein_names_refseq": "CG17584-PA; Or49b-PA; odorant receptor 49b", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17584)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10458908;10731132;10943836;12537572;16615896", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29QF2;Q9U6X5", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9V6H2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V6U8-1", "uniprot_id": [ { "id": "UBA3_DROME", "url": "https://www.uniprot.org/uniprot/Q9V6U8", "type": "external" } ], "mass": 50032.0, "length": 450, "protein_name": "Nedd8-activating enzyme E1 catalytic subunit", "gene_name": "Uba3", "organism": "Fruit fly", "refseq_name": "Ubiquitin-like activating enzyme 3", "refseq_ac": [ { "id": "NP_610913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610913", "type": "external" } ], "gene_names_uniprotkb": "Uba3; CG13343", "gene_names_refseq": "CG13343; Dmel\\CG13343; Uba3; dUba3; l(2)SH2 2028; l(2)SH2028", "protein_names_uniprotkb": "Nedd8-activating enzyme E1 catalytic subunit; 6.2.1.64; Ubiquitin-activating enzyme 3 homolog", "protein_names_refseq": "CG13343-PA; Uba3-PA; Ubiquitin-like activating enzyme 3; human Uba3 homologue; lethal (2) SH2028; ubiquitin activating enzyme 3", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13343); (R-DME-983168)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;21931660", "class_list": "", "function": "Catalytic subunit of the dimeric Uba3-APP-BP1 E1 enzyme. E1 activates Nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a Nedd8-Uba3 thioester and free AMP. E1 finally transfers Nedd8 to the catalytic cysteine of UbcE2M. Required for Cul1 and Cul3 neddylation. Negatively regulates full-length ci stability and hedgehog signaling., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4QPQ3;Q960K2", "ec_number_list": [ { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "6.2.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019781 NEDD8 activating enzyme activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0120500 NAE1-UBA3 complex", "go_biological_process": "GO:0045116 protein neddylation;GO:0045879 negative regulation of smoothened signaling pathway;GO:0061059 positive regulation of peptidoglycan recognition protein signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9V6U8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V7D2-1", "uniprot_id": [ { "id": "VATD1_DROME", "url": "https://www.uniprot.org/uniprot/Q9V7D2", "type": "external" } ], "mass": 27627.0, "length": 246, "protein_name": "V-type proton ATPase subunit D 1", "gene_name": "Vha36-1", "organism": "Fruit fly", "refseq_name": "vacuolar H[+] ATPase 36kD subunit 1", "refseq_ac": [ { "id": "NP_651987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651987", "type": "external" } ], "gene_names_uniprotkb": "Vha36-1; CG8186; Vha36", "gene_names_refseq": "ATP6V1D; CG8186; Dmel\\CG8186; Vha36-1; Vha36; VhaD; anon-WO0153538.20; anon-WO0153538.21; anon-WO0153538.28; anon-WO02059370.27; l(2)k07207; vha36-1; vha36", "protein_names_uniprotkb": "V-type proton ATPase subunit D 1; V-ATPase subunit D 1; Vacuolar H+ ATPase subunit 36-1; Vacuolar proton pump subunit D 1; dV-ATPase D", "protein_names_refseq": "CG8186-PA; Vha36-1-PA; vacuolar H-ATPase subunit D; vacuolar H[+] ATPase 36kD subunit 1; vacuolar H[+] ATPase subunit 36-1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8186); (R-DME-1222556); (R-DME-6798695); (R-DME-77387); (R-DME-917977); (R-DME-9639288); (R-DME-983712)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0033176 proton-transporting V-type ATPase complex;GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain;GO:0033181 plasma membrane proton-transporting V-type ATPase complex", "go_biological_process": "GO:0007035 vacuolar acidification;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9V7D2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V7H4-1", "uniprot_id": [ { "id": "TM131_DROME", "url": "https://www.uniprot.org/uniprot/Q9V7H4", "type": "external" } ], "mass": 173321.0, "length": 1567, "protein_name": "Transmembrane protein 131 homolog", "gene_name": "Tmem131", "organism": "Fruit fly", "refseq_name": "transmembrane protein 131, isoform B", "refseq_ac": [ { "id": "NP_001286471", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286471", "type": "external" } ], "gene_names_uniprotkb": "Tmem131; CG8370", "gene_names_refseq": "CG8370; Dmel\\CG8370; Tmem131; tmem131", "protein_names_uniprotkb": "Transmembrane protein 131 homolog", "protein_names_refseq": "CG8370-PB; Tmem131-PB; transmembrane protein 131, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8370)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;18327897;32095531", "class_list": "", "function": "Collagen binding transmembrane protein involved in collagen secretion, probably by recruiting the ER-to-Golgi transport complex TRAPPIII., [UniProtKB, PubMed]", "predicted_glycosites": 16, "predicted_n_glycosites": 13, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4LFJ4;Q0IGX2;Q960K9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0032964 collagen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9V7H4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V817-1", "uniprot_id": [ { "id": "MTH4_DROME", "url": "https://www.uniprot.org/uniprot/Q9V817", "type": "external" } ], "mass": 59240.0, "length": 517, "protein_name": "Probable G protein-coupled receptor Mth-like 4", "gene_name": "mthl4", "organism": "Fruit fly", "refseq_name": "methuselah-like 4", "refseq_ac": [ { "id": "NP_788394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788394", "type": "external" } ], "gene_names_uniprotkb": "mthl4; CG6536", "gene_names_refseq": "CG6536; Dmel\\CG6536; Mthl4; anon-WO0170980.55; anon-WO0170980.56; mthl4", "protein_names_uniprotkb": "Probable G protein-coupled receptor Mth-like 4; Protein methuselah-like 4", "protein_names_refseq": "CG6536-PB; Mth-like 4; methuselah-like 4; mthl4-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6536)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;10908591;12537572", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A1ZAT1", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0042594 response to starvation;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9V817-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V998-1", "uniprot_id": [ { "id": "UBL5_DROME", "url": "https://www.uniprot.org/uniprot/Q9V998", "type": "external" } ], "mass": 8570.0, "length": 73, "protein_name": "Ubiquitin-like protein 5", "gene_name": "ubl", "organism": "Fruit fly", "refseq_name": "ubiquitin like", "refseq_ac": [ { "id": "NP_610239", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610239", "type": "external" } ], "gene_names_uniprotkb": "ubl; CG3450; l(2)k03203", "gene_names_refseq": "CG3450; Dmel\\CG3450; Ubl; dubl; l(2)k03203; mut182; ubl", "protein_names_uniprotkb": "Ubiquitin-like protein 5", "protein_names_refseq": "CG3450-PA; drosophila ubiquitin like; lethal (2) k03203; ubiquitin like; ubl-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3450)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4QPS6", "ec_number_list": [], "go_molecular_function": "GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9V998-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V9A8-1", "uniprot_id": [ { "id": "PHTF_DROME", "url": "https://www.uniprot.org/uniprot/Q9V9A8", "type": "external" } ], "mass": 97635.0, "length": 880, "protein_name": "Protein phtf", "gene_name": "phtf", "organism": "Fruit fly", "refseq_name": "phtf", "refseq_ac": [ { "id": "NP_610232", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610232", "type": "external" } ], "gene_names_uniprotkb": "phtf; CG3268", "gene_names_refseq": "BcDNA.GH08636; BcDNA:GH08636; CG3268; Dmel\\CG3268; d-phtf; phtf", "protein_names_uniprotkb": "Protein phtf", "protein_names_refseq": "CG3268-PA; phtf-PA; phtf; putative homeodomain transcription factor", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3268)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10729229;10731132;10731138;12537572;18327897", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9TW25", "ec_number_list": [], "go_molecular_function": "GO:0015267 channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9V9A8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V9I4-1", "uniprot_id": [ { "id": "OR42B_DROME", "url": "https://www.uniprot.org/uniprot/Q9V9I4", "type": "external" } ], "mass": 46074.0, "length": 399, "protein_name": "Odorant receptor 42b", "gene_name": "Or42b", "organism": "Fruit fly", "refseq_name": "odorant receptor 42b", "refseq_ac": [ { "id": "NP_523624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523624", "type": "external" } ], "gene_names_uniprotkb": "Or42b; CG12754", "gene_names_refseq": "41E.1; 42b; CG12754; DOR118; Dmel\\CG12754; OR42b; Or42b; Or42", "protein_names_uniprotkb": "Odorant receptor 42b", "protein_names_refseq": "CG12754-PA; Or42b-PA; odorant receptor 42b", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12754)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;10943836;12537572;21613503;21857978", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to ethyl acetate and pentyl acetate., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9V9I4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9V9X4-1", "uniprot_id": [ { "id": "MTNA_DROME", "url": "https://www.uniprot.org/uniprot/Q9V9X4", "type": "external" } ], "mass": 39108.0, "length": 364, "protein_name": "Methylthioribose-1-phosphate isomerase 1", "gene_name": "Mri1", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": [ { "id": "NP_001263144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263144", "type": "external" } ], "gene_names_uniprotkb": "Mri1; CG11334", "gene_names_refseq": "CG11334; Dmel\\CG11334", "protein_names_uniprotkb": "Methylthioribose-1-phosphate isomerase 1; 5.3.1.23; M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase; Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein", "protein_names_refseq": "CG11334-PC; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11334); (R-DME-1237112)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)., [UniProtKB, HAMAP]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4KI38", "ec_number_list": [ { "id": "5.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.23", "type": "external" } ], "go_molecular_function": "GO:0046523 S-methyl-5-thioribose-1-phosphate isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0019509 L-methionine salvage from methylthioadenosine", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9V9X4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VA14-1", "uniprot_id": [ { "id": "Q9VA14_DROME", "url": "https://www.uniprot.org/uniprot/Q9VA14", "type": "external" } ], "mass": 58654.0, "length": 521, "protein_name": "Proton-coupled folate transporter", "gene_name": "Dmel\\CG15553", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_651841", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651841", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG15553; CG15553; Dmel_CG15553", "gene_names_refseq": "CG15553; Dmel\\CG15553", "protein_names_uniprotkb": "Proton-coupled folate transporter", "protein_names_refseq": "CG15553-PC; uncharacterized protein", "tax_id": 7227, "disease": "hereditary folate malabsorption (Disease Ontology:DOID:0111678); chronic kidney disease (Disease Ontology:DOID:784)", "pathway": " (dme:Dmel_CG15553); (R-DME-196757); (R-DME-917937); (R-DME-9707616)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VA14-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VA38-1", "uniprot_id": [ { "id": "WARTS_DROME", "url": "https://www.uniprot.org/uniprot/Q9VA38", "type": "external" } ], "mass": 122488.0, "length": 1105, "protein_name": "Serine/threonine-protein kinase Warts", "gene_name": "wts", "organism": "Fruit fly", "refseq_name": "warts", "refseq_ac": [ { "id": "NP_733403", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_733403", "type": "external" } ], "gene_names_uniprotkb": "wts; CG12072", "gene_names_refseq": "CG12072; Dlats; Dmel\\CG12072; LATS1; LATS; Lats/Warts; Lats1/2; Lats; MENE (3R)-G; WTS/LATS; WTS; Warts/Lats; Warts; Wts/Lats; Wts; dmLATS; l(3)100Aa; lats; lts; warts/lats; wart; wts/lats; wts", "protein_names_uniprotkb": "Serine/threonine-protein kinase Warts; 2.7.11.1", "protein_names_refseq": "CG12072-PA; LATS1/2; Warts/Lats; large tumor suppressor; large tumor supressor; miracle-gro; warts kinase; warts/D-lats; warts/large tumour suppressor; warts; wts-PA", "tax_id": 7227, "disease": "benign neoplasm (Disease Ontology:DOID:0060072); neurodegenerative disease (Disease Ontology:DOID:1289); cancer (Disease Ontology:DOID:162); kidney cancer (Disease Ontology:DOID:263); carcinoma (Disease Ontology:DOID:305); peripheral nerve sheath neoplasm (Disease Ontology:DOID:3193); autosomal dominant polycystic kidney disease (Disease Ontology:DOID:898); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG12072); (R-DME-2028269); (R-DME-390089); (R-DME-390098); (R-DME-390150); (R-DME-390178); (R-DME-451806)", "pathway_count": 7, "publication_count": 23, "publication_id_list": "10731132;12202036;12223493;12537572;12941273;12941274;14502294;14502295;14561774;15766530;16096061;16980976;17174922;17347649;17889654;18245354;18256197;18818081;19289086;19330023;19710173;19733165;20303269", "class_list": "", "function": "Negative regulator of Yorkie (Yki) in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Inhibits nuclear localization of Yki. Regulates salivary gland degradation in a PI3K-dependent manner and Yki- and Sd-independent, mechanism., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 8, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "5.6.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.8", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0106037 apicomedial cortex", "go_biological_process": "GO:0001708 cell fate specification;GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0048814 regulation of dendrite morphogenesis;GO:0090090 negative regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 2.4, "record_id": "Q9VA38-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VAG4-1", "uniprot_id": [ { "id": "VP16B_DROME", "url": "https://www.uniprot.org/uniprot/Q9VAG4", "type": "external" } ], "mass": 50412.0, "length": 447, "protein_name": "Vacuolar protein sorting-associated protein 16B", "gene_name": "Vps16B", "organism": "Fruit fly", "refseq_name": "vacuolar protein sorting 16B", "refseq_ac": [ { "id": "NP_651731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651731", "type": "external" } ], "gene_names_uniprotkb": "Vps16B; CG18112; fob", "gene_names_refseq": "CG18112; Dmel\\CG18112; Vps16B; Vps16b; dVps16B; fob", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 16B; Protein full-of-bacteria", "protein_names_refseq": "CG18112-PA; Vps16B-PA; full-of-bacteria; vacuolar protein sorting 16B", "tax_id": 7227, "disease": "ARC syndrome (Disease Ontology:DOID:0050763); arthrogryposis, renal dysfunction, and cholestasis 2 (Disease Ontology:DOID:0111354)", "pathway": " (dme:Dmel_CG18112)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;21282466;24554766", "class_list": "", "function": "Essential for phagosome maturation and the innate immune response to bacteria. During phagosome maturation it is required for the fusion of late endosomes/lysosomes and phagosomes (PubMed:21282466). Not required for autophagic flux (PubMed:24554766)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030897 HOPS complex;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0007034 vacuolar transport;GO:0090382 phagosome maturation;GO:0035542 regulation of SNARE complex assembly;GO:0006886 intracellular protein transport;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VAG4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VAK8-1", "uniprot_id": [ { "id": "DIE_DROME", "url": "https://www.uniprot.org/uniprot/Q9VAK8", "type": "external" } ], "mass": 12448.0, "length": 115, "protein_name": "Protein Diedel", "gene_name": "Diedel", "organism": "Fruit fly", "refseq_name": "diedel", "refseq_ac": [ { "id": "NP_651695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651695", "type": "external" } ], "gene_names_uniprotkb": "Diedel; CG11501; die", "gene_names_refseq": "BcDNA:RH38110; CG11501; Diedel; Die; Dmel\\CG11501; diedel; die", "protein_names_uniprotkb": "Protein Diedel", "protein_names_refseq": "CG11501-PA; Diedel-PA; diedel", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11501)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;22442689;26739560;30036358", "class_list": "", "function": "Cytokine which promotes survival following infection by Sindbis virus by suppressing the immune deficiency pathway (PubMed:26739560). Following infection by the enteropathogenic bacteria E.carotovora limits intestinal stem cells proliferation (PubMed:30036358). When secreted from muscle or adipose tissue, can attenuate age-related intestinal tissue degeneration by inhibiting apoptosis (PubMed:30036358)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0051607 defense response to virus;GO:0009617 response to bacterium;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VAK8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VAM9-1", "uniprot_id": [ { "id": "MESH1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VAM9", "type": "external" } ], "mass": 20569.0, "length": 179, "protein_name": "Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1", "gene_name": "Mesh1", "organism": "Fruit fly", "refseq_name": "metazoan SpoT homolog-1", "refseq_ac": [ { "id": "NP_651682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651682", "type": "external" } ], "gene_names_uniprotkb": "Mesh1; CG11900", "gene_names_refseq": "CG11900; Dmel\\CG11900; Mesh1; Q9VAM9", "protein_names_uniprotkb": "Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1; (ppGpp)ase; 3.1.7.2; Mesh1; Metazoan SpoT homolog 1; Penta-phosphate guanosine-3'-pyrophosphohydrolase", "protein_names_refseq": "CG11900-PA; Mesh1-PA; metazoan SpoT homolog-1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11900)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;20818390", "class_list": "", "function": "ppGpp hydrolyzing enzyme involved in starvation response., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.7.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.7.2", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008893 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity", "go_cellular_component": "", "go_biological_process": "GO:0042594 response to starvation;GO:0015971 guanosine tetraphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VAM9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VAT2-1", "uniprot_id": [ { "id": "DCA10_DROME", "url": "https://www.uniprot.org/uniprot/Q9VAT2", "type": "external" } ], "mass": 69566.0, "length": 621, "protein_name": "DDB1- and CUL4-associated factor 10 homolog", "gene_name": "CG1523", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_651635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651635", "type": "external" } ], "gene_names_uniprotkb": "CG1523", "gene_names_refseq": "CG1523; Dmel\\CG1523", "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 10 homolog; WD repeat-containing protein 32 homolog", "protein_names_refseq": "CG1523-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1523); (R-DME-8951664)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18327897", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q960M2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0080008 Cul4-RING E3 ubiquitin ligase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VAT2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VAY3-1", "uniprot_id": [ { "id": "MFRN_DROME", "url": "https://www.uniprot.org/uniprot/Q9VAY3", "type": "external" } ], "mass": 41795.0, "length": 379, "protein_name": "Mitoferrin", "gene_name": "mfrn", "organism": "Fruit fly", "refseq_name": "mitoferrin", "refseq_ac": [ { "id": "NP_651600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651600", "type": "external" } ], "gene_names_uniprotkb": "mfrn; CG4963", "gene_names_refseq": "CG4963; Dmel\\CG4963; HD35059; Mfrn; anon-EST:fe2H5; dmfrn; mfrn", "protein_names_uniprotkb": "Mitoferrin; dmfrn", "protein_names_refseq": "CG4963-PA; anon-fast-evolving-2H5; mfrn-PA; mitoferrin", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4963)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;19453295;9275195", "class_list": "", "function": "Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9NHY6", "ec_number_list": [], "go_molecular_function": "GO:0015093 ferrous iron transmembrane transporter activity;GO:0005381 iron ion transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0048515 spermatid differentiation;GO:0060586 multicellular organismal-level iron ion homeostasis;GO:0048250 iron import into the mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VAY3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VB25-1", "uniprot_id": [ { "id": "KL98A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VB25", "type": "external" } ], "mass": 141562.0, "length": 1265, "protein_name": "Kinesin-like protein Klp98A", "gene_name": "Klp98A", "organism": "Fruit fly", "refseq_name": "Kinesin-like protein at 98A, isoform B", "refseq_ac": [ { "id": "NP_001247339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247339", "type": "external" } ], "gene_names_uniprotkb": "Klp98A; CG5658", "gene_names_refseq": "CG5658; DmKlp98A; DmSNX23; Dmel\\CG5658; KIF 16A; KIF16A/B; KLP6; KLP98A; Klp6; Klp98A; Klp98a; Snx23; klp98A", "protein_names_uniprotkb": "Kinesin-like protein Klp98A", "protein_names_refseq": "CG5658-PB; Kinesin-like protein at 98A, isoform B; Kinesin7B; Klp98A-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5658)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;1924306;26659188;26763909", "class_list": "", "function": "Plus end-directed motor protein involved in asymmetric cell division of sensory organ precursor (SOP) cells by playing a role in the asymmetric localization of Sara-expressing endosomes to the pIIa daughter cell but not to the pIIb cell. Targets Sara-expressing endosomes to the central spindle which is symmetrically arranged in early cell division. During late cytokinesis, central spindle asymmetry is generated by enrichment of Patronin on the pIIb side which protects microtubules from depolymerization by Klp10A while unprotected microtubules on the pIIa side are disassembled by Klp10A, leading to the asymmetric delivery of Sara-expressing endosomes to the pIIa daughter cell (PubMed:26659188). Also plays a role in regulation of autophagosome formation, fusion and positioning and is required for normal localization of Rab14 (PubMed:26763909)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4K7N6;Q00088;Q8SZH6", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:1901981 phosphatidylinositol phosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005874 microtubule;GO:0005871 kinesin complex", "go_biological_process": "GO:0006914 autophagy;GO:0045022 early endosome to late endosome transport;GO:0045056 transcytosis;GO:0047496 vesicle transport along microtubule;GO:0045167 asymmetric protein localization involved in cell fate determination", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VB25-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VB26-1", "uniprot_id": [ { "id": "GR98B_DROME", "url": "https://www.uniprot.org/uniprot/Q9VB26", "type": "external" } ], "mass": 46852.0, "length": 403, "protein_name": "Putative gustatory receptor 98b", "gene_name": "Gr98b", "organism": "Fruit fly", "refseq_name": "gustatory receptor 98b", "refseq_ac": [ { "id": "NP_733213", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_733213", "type": "external" } ], "gene_names_uniprotkb": "Gr98b; CG31059; GR98B.2", "gene_names_refseq": "98B.2; CG12884; CG31059; Dmel\\CG31059; GR98B.2; GR98b; Gr98A1; Gr98B2; Gr98b", "protein_names_uniprotkb": "Putative gustatory receptor 98b", "protein_names_refseq": "CG31059-PA; Gr98b-PA; gustatory receptor 98B.2; gustatory receptor 98b", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31059)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10710312;10731132;12537572", "class_list": "", "function": "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007165 signal transduction;GO:0034220 monoatomic ion transmembrane transport;GO:0050909 sensory perception of taste;GO:1901354 response to L-canavanine", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VB26-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VB30-1", "uniprot_id": [ { "id": "GR98A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VB30", "type": "external" } ], "mass": 45536.0, "length": 391, "protein_name": "Putative gustatory receptor 98a", "gene_name": "Gr98a", "organism": "Fruit fly", "refseq_name": "gustatory receptor 98a", "refseq_ac": [ { "id": "NP_651564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651564", "type": "external" } ], "gene_names_uniprotkb": "Gr98a; CG13976; GR98B.4", "gene_names_refseq": "98B.4; CG13976; Dmel\\CG13976; GR98B.4; GR98a; Gr98B4; Gr98a", "protein_names_uniprotkb": "Putative gustatory receptor 98a", "protein_names_refseq": "CG13976-PA; Gr98a-PA; gustatory receptor 98B.4; gustatory receptor 98a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13976)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10710312;10731132;12537572", "class_list": "", "function": "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0008049 male courtship behavior;GO:0007165 signal transduction;GO:0034220 monoatomic ion transmembrane transport;GO:0007635 chemosensory behavior;GO:0050909 sensory perception of taste", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VB30-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VBE7-1", "uniprot_id": [ { "id": "Q9VBE7_DROME", "url": "https://www.uniprot.org/uniprot/Q9VBE7", "type": "external" } ], "mass": 58915.0, "length": 523, "protein_name": "Transmembrane protein 26", "gene_name": "Dmel\\CG14238", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_651480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651480", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG14238; CG14238; Dmel_CG14238", "gene_names_refseq": "CG14238; Dmel\\CG14238", "protein_names_uniprotkb": "Transmembrane protein 26", "protein_names_refseq": "CG14238-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14238)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VBE7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VBL5-1", "uniprot_id": [ { "id": "A4GT2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VBL5", "type": "external" } ], "mass": 44328.0, "length": 395, "protein_name": "Alpha1,4-N-acetylgalactosaminyltransferase 2", "gene_name": "alpha4GT2", "organism": "Fruit fly", "refseq_name": "alpha1,4-galactosyltransferase 2", "refseq_ac": [ { "id": "NP_651434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651434", "type": "external" } ], "gene_names_uniprotkb": "alpha4GT2; CG5878", "gene_names_refseq": "CG5878; Dmel\\CG5878; alpha4GT2", "protein_names_uniprotkb": "Alpha1,4-N-acetylgalactosaminyltransferase 2; 2.4.1.-; Alpha1,4-galactosyltransferase 2; UDP-GalNAc:betaGalNAc alpha1-4GalNAc-transferase", "protein_names_refseq": "CG5878-PB; alpha1,4-galactosyltransferase 2; alpha4GT2-PB", "tax_id": 7227, "disease": "pancreatic cancer (Disease Ontology:DOID:1793)", "pathway": " (dme:Dmel_CG5878); (R-DME-913709)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537572;17498683;20176925", "class_list": "", "function": "An alpha1,4-N-acetylgalactosaminyltransferase that catalyzes the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc in an alpha-1,4 linkage to substrates with a terminal GalNAc (PubMed:17498683). Functions downstream of beta4GalNAcTA or beta4GalNAcTB to add the 5th sugar during glycosphingolipid elongation to form GalNAc-alpha1-4GalNAc-beta1-4GlcNAc-beta1-3Man-beta1-4Glc-beta1-1Cer (N5) from GalNAc-beta1-4GlcNAc-beta1-3Man-beta1-4Glc-beta1-1Cer (N4) (PubMed:17498683, PubMed:20176925). Non-essential regulator of Notch signaling; alters the glycosphingolipid makeup of the cell membrane, which affects the endocytosis and subcellular localization of Notch ligands (PubMed:20176925)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0035248 alpha-1,4-N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006688 glycosphingolipid biosynthetic process;GO:0006679 glucosylceramide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VBL5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VBL7-1", "uniprot_id": [ { "id": "MS57B_DROME", "url": "https://www.uniprot.org/uniprot/Q9VBL7", "type": "external" } ], "mass": 4184.0, "length": 40, "protein_name": "Accessory gland-specific peptide 57Db", "gene_name": "Mst57Db", "organism": "Fruit fly", "refseq_name": "Male-specific RNA 57Db", "refseq_ac": [ { "id": "NP_524499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524499", "type": "external" } ], "gene_names_uniprotkb": "Mst57Db; CG5016", "gene_names_refseq": "CG5016; Dmel\\CG5016; Mst57Db; mst(2)ag-1; mst-1", "protein_names_uniprotkb": "Accessory gland-specific peptide 57Db; Male accessory gland secretory protein 57Db", "protein_names_refseq": "CG5016-PA; Male-specific RNA 57Db; Mst57Db-PA; male specific transcript 57D", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5016)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;7711745", "class_list": "", "function": "Transferred from male to female during mating and may affect egglaying and behavior after mating., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24391", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007320 insemination;GO:0007618 mating;GO:0045924 regulation of female receptivity;GO:0018991 egg-laying behavior", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VBL7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VBP9-1", "uniprot_id": [ { "id": "NPL4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VBP9", "type": "external" } ], "mass": 73361.0, "length": 652, "protein_name": "Nuclear protein localization protein 4 homolog", "gene_name": "Npl4", "organism": "Fruit fly", "refseq_name": "nuclear protein localization 4, isoform D", "refseq_ac": [ { "id": "NP_001163731", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163731", "type": "external" } ], "gene_names_uniprotkb": "Npl4; CG4673", "gene_names_refseq": "CG4673; Dmel\\CG4673; NPL4; Npl4; dNPLOC4; dNp14; dNpl4; npl4", "protein_names_uniprotkb": "Nuclear protein localization protein 4 homolog", "protein_names_refseq": "CG4673-PD; Npl4 ortholog; Npl4-PD; nuclear protein localization 4, isoform D", "tax_id": 7227, "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)", "pathway": " (dme:Dmel_CG4673); (R-DME-110320); (R-DME-8951664); (R-DME-9755511)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10731132;12537572;15899868;17372656;18327897;26471729", "class_list": "", "function": "May be part of a complex that binds ubiquitinated proteins and that is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "C9QPJ1;E1JIX5;H8F4R9;Q8IMS6;Q95U63", "ec_number_list": [], "go_molecular_function": "GO:0071795 K11-linked polyubiquitin modification-dependent protein binding;GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0098586 cellular response to virus;GO:0045879 negative regulation of smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VBP9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VBR8-1", "uniprot_id": [ { "id": "Q9VBR8_DROME", "url": "https://www.uniprot.org/uniprot/Q9VBR8", "type": "external" } ], "mass": 165927.0, "length": 1426, "protein_name": "Zinc finger protein Xfin", "gene_name": "anon-96CDa", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_651389", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651389", "type": "external" } ], "gene_names_uniprotkb": "anon-96CDa; CG11902; Dmel\\CG11902; Dmel_CG11902", "gene_names_refseq": "CG11902; Dmel\\CG11902; anon-96CDa", "protein_names_uniprotkb": "Zinc finger protein Xfin", "protein_names_refseq": "CG11902-PB; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11902)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9Y089", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VBR8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VBY8-1", "uniprot_id": [ { "id": "UN13B_DROME", "url": "https://www.uniprot.org/uniprot/Q9VBY8", "type": "external" } ], "mass": 131921.0, "length": 1153, "protein_name": "Protein unc-13 homolog 4B", "gene_name": "stac", "organism": "Fruit fly", "refseq_name": "staccato, isoform D", "refseq_ac": [ { "id": "NP_001097909", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097909", "type": "external" } ], "gene_names_uniprotkb": "stac; CG34349; Unc-13-4B", "gene_names_refseq": "BP1013; CG11819; CG34037; CG34349; Dmel\\CG34349; Stac; Unc-13-4B; dunc-13-4B; stac; unc-13-4B", "protein_names_uniprotkb": "Protein unc-13 homolog 4B; Protein Staccato", "protein_names_refseq": "CG34349-PD; Unc-13 ortholog 4B; Uncoordinated-13 4B; stac-PD; staccato, isoform D", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG34349)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;27323327;9813038", "class_list": "", "function": "Essential for tracheal development in embryos. Functions with the GTPase Rab39 and downstream of dnd, to regulate lumen fusion between previously separate tracheal branches (anastomosis). Essential component of secretory lysosome-related organelles (SLs) that are present in the tracheal fusion tip cells (FCs). Mediates intracellular fusion of the extending tracheal stalk cell lumen in the FCs by recruiting the SNARE complex component Syx1A to the SLs, this may then enable the SLs to interact with complementary SNAREs (such as Syb) present in the apical membrane of the FC-FC interface and the membranes of the separate tracheal stalk cells. May also function in the maturation and exocytosis of the SLs., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4KHI5;A8JRA6;B3DN10;C6SV37", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0099503 secretory vesicle;GO:0005856 cytoskeleton;GO:0005764 lysosome;GO:0005770 late endosome;GO:0030175 filopodium", "go_biological_process": "GO:0007269 neurotransmitter secretion;GO:0016082 synaptic vesicle priming;GO:0035147 branch fusion, open tracheal system", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VBY8-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VBZ5-1", "uniprot_id": [ { "id": "YTHDF_DROME", "url": "https://www.uniprot.org/uniprot/Q9VBZ5", "type": "external" } ], "mass": 78916.0, "length": 700, "protein_name": "YTH domain-containing family protein", "gene_name": "Ythdf", "organism": "Fruit fly", "refseq_name": "YTH N6-methyladenosine RNA binding protein, isoform C", "refseq_ac": [ { "id": "NP_001097905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001097905", "type": "external" } ], "gene_names_uniprotkb": "Ythdf; CG6422", "gene_names_refseq": "CG6422; Dmel\\CG6422; YTHDF; Ythdf; ythdf", "protein_names_uniprotkb": "YTH domain-containing family protein", "protein_names_refseq": "CG6422-PC; YTH N6-methyladenosine RNA binding protein, isoform C; Ythdf-PC", "tax_id": 7227, "disease": "disease of metabolism (Disease Ontology:DOID:0014667); colorectal cancer (Disease Ontology:DOID:9256)", "pathway": " (dme:Dmel_CG6422)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;12537569;12537572;27919077;27919081;28675155;33428246", "class_list": "", "function": "Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:28675155, PubMed:33428246). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA processing and stability (PubMed:28675155, PubMed:33428246). Together with Fmr1, regulates axonal growth in the mushroom bodies and neuromuscular junctions by repressing the translation of several mRNAs, such as those of chic and futsch (PubMed:33428246)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8JRA4;Q8IGP2;Q8IMU5", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0003729 mRNA binding;GO:1990247 N6-methyladenosine-containing RNA reader activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0061157 mRNA destabilization;GO:0030517 negative regulation of axon extension", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9VBZ5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VC07-1", "uniprot_id": [ { "id": "TRF42_DROME", "url": "https://www.uniprot.org/uniprot/Q9VC07", "type": "external" } ], "mass": 44997.0, "length": 407, "protein_name": "Inactive non-canonical poly(A) RNA polymerase protein Trf4-2", "gene_name": "Trf4-2", "organism": "Fruit fly", "refseq_name": "topoisomerase related function 4-2, isoform B", "refseq_ac": [ { "id": "NP_001262941", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262941", "type": "external" } ], "gene_names_uniprotkb": "Trf4-2; CG17462", "gene_names_refseq": "AAF56369; CG17462; DmTRF4-2; Dmel\\CG17462; Trf4-2", "protein_names_uniprotkb": "Inactive non-canonical poly(A) RNA polymerase protein Trf4-2; Topoisomerase 1-related protein 4-2", "protein_names_refseq": "CG17462-PB; Trf4-2-PB; topoisomerase related function 4-2, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17462)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18765642", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:1990817 poly(A) RNA polymerase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0031499 TRAMP complex", "go_biological_process": "GO:0031123 RNA 3'-end processing;GO:0071046 nuclear polyadenylation-dependent ncRNA catabolic process;GO:0043634 polyadenylation-dependent ncRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VC07-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VC76-1", "uniprot_id": [ { "id": "Q9VC76_DROME", "url": "https://www.uniprot.org/uniprot/Q9VC76", "type": "external" } ], "mass": 37149.0, "length": 331, "protein_name": "F-box only protein 11", "gene_name": "Dmel\\CG13615", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_651261", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651261", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG13615; CG13615; Dmel_CG13615", "gene_names_refseq": "CG13615; Dmel\\CG13615", "protein_names_uniprotkb": "F-box only protein 11", "protein_names_refseq": "CG13615-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13615)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VC76-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VCG4-1", "uniprot_id": [ { "id": "NDC1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VCG4", "type": "external" } ], "mass": 65387.0, "length": 578, "protein_name": "Nucleoporin Ndc1", "gene_name": "Ndc1", "organism": "Fruit fly", "refseq_name": "nuclear division cycle 1", "refseq_ac": [ { "id": "NP_651191", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651191", "type": "external" } ], "gene_names_uniprotkb": "Ndc1; CG5857", "gene_names_refseq": "CG5857; Dmel\\CG5857; NDC1; Ndc1; ndc1", "protein_names_uniprotkb": "Nucleoporin Ndc1", "protein_names_refseq": "CG5857-PA; Ndc1 ortholog; Ndc1-PA; nuclear division cycle 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5857); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236); (R-DME-1855170); (R-DME-1855196); (R-DME-1855229); (R-DME-3108214); (R-DME-3301854); (R-DME-3371453); (R-DME-4085377); (R-DME-4551638); (R-DME-4615885); (R-DME-9615933)", "pathway_count": 15, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18327897", "class_list": "", "function": "Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3YE69", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0070762 nuclear pore transmembrane ring;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0031965 nuclear membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006999 nuclear pore organization;GO:0006913 nucleocytoplasmic transport;GO:0015031 protein transport;GO:0051292 nuclear pore complex assembly;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VCG4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VCH5-1", "uniprot_id": [ { "id": "NUP98_DROME", "url": "https://www.uniprot.org/uniprot/Q9VCH5", "type": "external" } ], "mass": 210139.0, "length": 1960, "protein_name": "Nuclear pore complex protein Nup98-Nup96", "gene_name": "Nup98-96", "organism": "Fruit fly", "refseq_name": "nucleoporin 98-96kD, isoform C", "refseq_ac": [ { "id": "NP_001247266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247266", "type": "external" } ], "gene_names_uniprotkb": "Nup98-96; CG10198; Nup145; Nup98", "gene_names_refseq": "CG10198; CG10201; Dmel\\CG10198; NUP98-NUP96; NUP98; Nup 96; Nup 98; Nup-98; Nup96-98; Nup96; Nup98-96; Nup98-Nup96; Nup98/96; Nup98; Nup; l(3)95BCd; nup145; nup98-96; nup98", "protein_names_uniprotkb": "Nuclear pore complex protein Nup98-Nup96; 3.4.21.-; Nucleoporin Nup96; Nucleoporin Nup98; Nup96; Nup98", "protein_names_refseq": "CG10198-PC; Nup98-96-PC; nucleoporin 96; nucleoporin 98-96kD, isoform C; nucleoporin 98-96; nucleoporin 98; nucleoporin98-96", "tax_id": 7227, "disease": "T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (dme:Dmel_CG10198); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236); (R-DME-1855170); (R-DME-1855196); (R-DME-1855229); (R-DME-3108214); (R-DME-3301854); (R-DME-3371453); (R-DME-4085377); (R-DME-4551638); (R-DME-4615885); (R-DME-9615933)", "pathway_count": 15, "publication_count": 14, "publication_id_list": "10731132;12537572;20144760;20144761;20547758;21874015;21949861;25197089;25201876;25310983;25852164;28366641;28554770;40245499", "class_list": "", "function": "Part of the nuclear pore complex (NPC) (PubMed:25197089). Required for MAD import as part of the Nup107-160 complex and required for nuclear export of Moe probably via its association with Rae1 (PubMed:20547758, PubMed:28554770). Plays a role in nuclear mRNA export (PubMed:28554770). Promotes cell antiviral response by up-regulating FoxK-dependent antiviral gene transcription (PubMed:25197089, PubMed:25852164). In germline stem cells, involved in their maintenance and division together with the TGF-Beta and EGFR signaling pathways (PubMed:21949861). In larval lymph glands, has a role in the maintenance of hematopoiesis by regulating Pvr expression (PubMed:25201876)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Part of the nuclear pore complex (NPC) (PubMed:25310983). In the nucleoplasm, binds to transcriptionally active chromatin with a preference for regulatory regions; co-localizes with RNA polymerase II in a RNA-independent manner and before transition into transcription elongation (PubMed:20144760, PubMed:20144761, PubMed:28366641). Plays a role in the transcriptional memory process by stabilizing enhancer-promoter loops and by mediating anchoring of chromatin to the nuclear pore complex region (PubMed:28366641). During larval development, interacts with trx and MBD-R2 and regulates transcription of developmental genes including ecdysone-responsive genes such as Eip74 and E23 (PubMed:20144761, PubMed:25310983, PubMed:28366641)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Part of the nuclear pore complex (NPC)., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "B8A421;Q6NP55", "ec_number_list": [ { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0017171 serine hydrolase activity;GO:0031490 chromatin DNA binding;GO:0017056 structural constituent of nuclear pore;GO:0008139 nuclear localization sequence binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006508 proteolysis;GO:0006913 nucleocytoplasmic transport;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9VCH5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VCK1-1", "uniprot_id": [ { "id": "GILT2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VCK1", "type": "external" } ], "mass": 23506.0, "length": 207, "protein_name": "GILT-like protein 2", "gene_name": "GILT2", "organism": "Fruit fly", "refseq_name": "Gamma-interferon-inducible lysosomal thiol reductase 2", "refseq_ac": [ { "id": "NP_651166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651166", "type": "external" } ], "gene_names_uniprotkb": "GILT2; CG10157", "gene_names_refseq": "CG10157; Dmel\\CG10157; GILT2; GILT; anon-EST:Posey120", "protein_names_uniprotkb": "GILT-like protein 2; 1.8.-.-", "protein_names_refseq": "CG10157-PA; GILT2-PA; Gamma-interferon-inducible lysosomal thiol reductase 2; Gamma-interferon-inducible lysosomal thiol reductase", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10157); (R-DME-2132295)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;24491521", "class_list": "", "function": "Probable lysosomal thiol reductase that can reduce protein disulfide bonds (By similarity). Involved in the immune response to bacterial infection (PubMed:24491521)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0016667 oxidoreductase activity, acting on a sulfur group of donors;GO:0016491 oxidoreductase activity;GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:1900426 positive regulation of defense response to bacterium;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VCK1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VCS8-1", "uniprot_id": [ { "id": "OR94B_DROME", "url": "https://www.uniprot.org/uniprot/Q9VCS8", "type": "external" } ], "mass": 45262.0, "length": 383, "protein_name": "Odorant receptor 94b", "gene_name": "Or94b", "organism": "Fruit fly", "refseq_name": "odorant receptor 94b", "refseq_ac": [ { "id": "NP_524456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524456", "type": "external" } ], "gene_names_uniprotkb": "Or94b; CG6679", "gene_names_refseq": "94D.2; 94b; CG6679; DOR109; Dmel\\CG6679; OR94b; Or94b; anon-JP2002534971-A.31; anon-JP2002534971-A.32", "protein_names_uniprotkb": "Odorant receptor 94b", "protein_names_refseq": "CG6679-PA; Or94b-PA; odorant receptor 94b", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6679)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;21613503", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0099604 ligand-gated calcium channel activity;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0070588 calcium ion transmembrane transport;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VCS8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VCY0-1", "uniprot_id": [ { "id": "Q9VCY0_DROME", "url": "https://www.uniprot.org/uniprot/Q9VCY0", "type": "external" } ], "mass": 18715.0, "length": 158, "protein_name": "Buttonless", "gene_name": "btn", "organism": "Fruit fly", "refseq_name": "buttonless", "refseq_ac": [ { "id": "NP_732768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_732768", "type": "external" } ], "gene_names_uniprotkb": "btn; 13; BTN; CG5264; Dmel\\CG5264; Dmel_CG5264; MEOX", "gene_names_refseq": "1261/13; BTN; CG5264; Dmel\\CG5264; btn/MEOX; btn", "protein_names_uniprotkb": "Buttonless", "protein_names_refseq": "CG5264-PA; btn-PA; buttonless", "tax_id": 7227, "disease": "Klippel-Feil syndrome 2 (Disease Ontology:DOID:0080590); Klippel-Feil syndrome (Disease Ontology:DOID:10426); myocardial infarction (Disease Ontology:DOID:5844)", "pathway": " (dme:Dmel_CG5264)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VCY0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VCZ7-1", "uniprot_id": [ { "id": "Q9VCZ7_DROME", "url": "https://www.uniprot.org/uniprot/Q9VCZ7", "type": "external" } ], "mass": 26300.0, "length": 229, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG5376", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_651054", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651054", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG5376; CG5376; Dmel_CG5376", "gene_names_refseq": "CG5376; Dmel\\CG5376", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG5376-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5376)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VCZ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VD09-1", "uniprot_id": [ { "id": "PINTA_DROME", "url": "https://www.uniprot.org/uniprot/Q9VD09", "type": "external" } ], "mass": 31626.0, "length": 273, "protein_name": "Retinol-binding protein pinta", "gene_name": "pinta", "organism": "Fruit fly", "refseq_name": "prolonged depolarization afterpotential (PDA) is not apparent, isoform B", "refseq_ac": [ { "id": "NP_001287466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287466", "type": "external" } ], "gene_names_uniprotkb": "pinta; CG13848", "gene_names_refseq": "CG13848; CT33362; Dmel\\CG13848; PINTA; Pinta; pinta; sec14", "protein_names_uniprotkb": "Retinol-binding protein pinta; Prolonged depolarization afterpotential is not apparent", "protein_names_refseq": "CG13848-PB; Lyso-PA acyltransferase; pinta-PB; prolonged depolarization afterpotential (PDA) is not apparent, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13848); (R-DME-8877627)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537572;15917458", "class_list": "", "function": "Retinoid-binding protein which shows highest affinity for all-trans retinol. Can also bind all-trans forms of retinoic acid and retinal, but has lower affinity for cis form retinoids. Required in retinal pigment cells for rhodopsin biosynthesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1902936 phosphatidylinositol bisphosphate binding;GO:0019841 retinol binding;GO:0016918 retinal binding;GO:0005501 retinoid binding", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0007602 phototransduction;GO:0016063 rhodopsin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VD09-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VD64-1", "uniprot_id": [ { "id": "Q9VD64_DROME", "url": "https://www.uniprot.org/uniprot/Q9VD64", "type": "external" } ], "mass": 20066.0, "length": 179, "protein_name": "ADP-ribosylation factor-like protein 3", "gene_name": "dnd", "organism": "Fruit fly", "refseq_name": "dead end", "refseq_ac": [ { "id": "NP_650995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650995", "type": "external" } ], "gene_names_uniprotkb": "dnd; ARL3; Arl3; CG6560; Dmel\\CG6560; Dmel_CG6560; Dnd; Q9VD64; arl3", "gene_names_refseq": "ARL3; Arl3; CG6560; Dmel\\CG6560; Dnd; Q9VD64; arl3; dnd", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 3", "protein_names_refseq": "ADP-ribosylation factor-like 3; Arf-like 3; Arf-like-3; Arf-like3; CG6560-PA; dead end; dnd-PA", "tax_id": 7227, "disease": "Joubert syndrome (Disease Ontology:DOID:0050777); retinitis pigmentosa 2 (Disease Ontology:DOID:0110415); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); retinitis pigmentosa 83 (Disease Ontology:DOID:0112140)", "pathway": " (dme:Dmel_CG6560)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8SZF9", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0015031 protein transport;GO:0060271 cilium assembly;GO:0016192 vesicle-mediated transport;GO:0051649 establishment of localization in cell;GO:0035147 branch fusion, open tracheal system", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VD64-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VD72-1", "uniprot_id": [ { "id": "Q9VD72_DROME", "url": "https://www.uniprot.org/uniprot/Q9VD72", "type": "external" } ], "mass": 28497.0, "length": 254, "protein_name": "Vacuolar-sorting protein SNF8", "gene_name": "lsn", "organism": "Fruit fly", "refseq_name": "larsen", "refseq_ac": [ { "id": "NP_650987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650987", "type": "external" } ], "gene_names_uniprotkb": "lsn; CG6637; Dmel\\CG6637; Dmel_CG6637; Lsn; Vps22; vps22", "gene_names_refseq": "CG6637; Dmel\\CG6637; Lsn; Vps22; lsn; vps22", "protein_names_uniprotkb": "Vacuolar-sorting protein SNF8", "protein_names_refseq": "CG6637-PA; larsen; lsn-PA", "tax_id": 7227, "disease": "developmental and epileptic encephalopathy (Disease Ontology:DOID:0112202); cancer (Disease Ontology:DOID:162)", "pathway": " (dme:Dmel_CG6637); (R-DME-917729)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000814 ESCRT II complex", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0042981 regulation of apoptotic process;GO:0008104 intracellular protein localization;GO:0090148 membrane fission", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VD72-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VDD9-1", "uniprot_id": [ { "id": "TRM72_DROME", "url": "https://www.uniprot.org/uniprot/Q9VDD9", "type": "external" } ], "mass": 36226.0, "length": 320, "protein_name": "tRNA (guanosine(34)-2'-O)-methyltransferase", "gene_name": "Trm7-34", "organism": "Fruit fly", "refseq_name": "tRNA methyltransferase 7-34", "refseq_ac": [ { "id": "NP_650947", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650947", "type": "external" } ], "gene_names_uniprotkb": "Trm7-34; CG7009", "gene_names_refseq": "CG7009; Dmel\\CG7009; Trm7-34; Trm7_34; dTrm7_34", "protein_names_uniprotkb": "tRNA (guanosine(34)-2'-O)-methyltransferase; 2'-O-ribose RNA methyltransferase TRM7 homolog 2; 2.1.1.-; 2.1.1.207; tRNA methyltransferase 7-34", "protein_names_refseq": "CG7009-PA; Trm7-34-PA; tRNA methyltransferase 7-34", "tax_id": 7227, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); non-syndromic X-linked intellectual disability 9 (Disease Ontology:DOID:0112034)", "pathway": " (dme:Dmel_CG7009)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;31943105;36720500", "class_list": "", "function": "Methylates the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of substrate tRNAs (PubMed:31943105). May require WDR6 for methylation of the nucleotide at position 34 of the anticodon loop of substrate tRNAs (PubMed:31943105). Plays a role in neurogenesis (PubMed:36720500). Requisite for RNA-mediated gene silencing (PubMed:31943105). Modifies position 34 in tRNA(Leu(CAA)), tRNA(Leu(CAG)), tRNA(Phe(GAA)), and tRNA(Trp(CCA)) (PubMed:31943105)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.207", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.207", "type": "external" } ], "go_molecular_function": "GO:0008175 tRNA methyltransferase activity;GO:0016423 tRNA (guanine) methyltransferase activity;GO:1904047 S-adenosyl-L-methionine binding;GO:0141098 tRNA (cytidine(34)-2'-O)-methyltransferase activity;GO:0106340 tRNA (guanosine(34)-2'-O)-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002128 tRNA nucleoside ribose methylation;GO:0030488 tRNA methylation;GO:0022008 neurogenesis;GO:0002181 cytoplasmic translation;GO:0002129 wobble position guanine ribose methylation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VDD9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VDL1-1", "uniprot_id": [ { "id": "LOVG_DROME", "url": "https://www.uniprot.org/uniprot/Q9VDL1", "type": "external" } ], "mass": 30634.0, "length": 279, "protein_name": "Esterase CG5412", "gene_name": "CG5412", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_650895", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650895", "type": "external" } ], "gene_names_uniprotkb": "CG5412", "gene_names_refseq": "CG5412; Dmel\\CG5412", "protein_names_uniprotkb": "Esterase CG5412; 3.1.2.-", "protein_names_refseq": "CG5412-PA; uncharacterized protein", "tax_id": 7227, "disease": "ovarian cancer (Disease Ontology:DOID:2394)", "pathway": " (dme:Dmel_CG5412)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0017171 serine hydrolase activity;GO:0004622 phosphatidylcholine lysophospholipase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VDL1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VDM7-1", "uniprot_id": [ { "id": "Q9VDM7_DROME", "url": "https://www.uniprot.org/uniprot/Q9VDM7", "type": "external" } ], "mass": 42155.0, "length": 364, "protein_name": "Trimethyllysine dioxygenase, mitochondrial", "gene_name": "Tmlh", "organism": "Fruit fly", "refseq_name": "trimethyllysine hydroxylase", "refseq_ac": [ { "id": "NP_650886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650886", "type": "external" } ], "gene_names_uniprotkb": "Tmlh; CG4335; Dmel\\CG4335; Dmel_CG4335; TMLHE; TMLH", "gene_names_refseq": "CG4335; Dmel\\CG4335; TMLHE; TMLH; Tmlh", "protein_names_uniprotkb": "Trimethyllysine dioxygenase, mitochondrial; 1.14.11.8; Epsilon-trimethyllysine 2-oxoglutarate dioxygenase; TML hydroxylase; TML-alpha-ketoglutarate dioxygenase", "protein_names_refseq": "CG4335-PA; TML hydroxylase; Tmlh-PA; trimethyllysine hydroxylase", "tax_id": 7227, "disease": "autistic disorder (Disease Ontology:DOID:12849)", "pathway": " (dme:Dmel_CG4335); (R-DME-71262)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.8", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0050353 trimethyllysine dioxygenase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0045329 carnitine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VDM7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VDN2-1", "uniprot_id": [ { "id": "MT3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VDN2", "type": "external" } ], "mass": 4597.0, "length": 43, "protein_name": "Metallothionein-3", "gene_name": "MtnC", "organism": "Fruit fly", "refseq_name": "metallothionein C", "refseq_ac": [ { "id": "NP_650882", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650882", "type": "external" } ], "gene_names_uniprotkb": "MtnC; CG5097", "gene_names_refseq": "CG5097; Dmel\\CG5097; MTNC; MT; MtnC", "protein_names_uniprotkb": "Metallothionein-3; MT-3; Metallothionein C", "protein_names_refseq": "CG5097-PA; MtnC-PA; metallothionein C; metallothionein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5097)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12505988;12537572", "class_list": "", "function": "This protein binds cations of several transition elements. Thought to be involved in metal ion homeostasis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0010038 response to metal ion;GO:1990748 cellular detoxification;GO:0140961 cellular detoxification of metal ion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VDN2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VDQ7-1", "uniprot_id": [ { "id": "NAA25_DROME", "url": "https://www.uniprot.org/uniprot/Q9VDQ7", "type": "external" } ], "mass": 109110.0, "length": 948, "protein_name": "Phagocyte signaling-impaired protein", "gene_name": "psidin", "organism": "Fruit fly", "refseq_name": "phagocyte signaling impaired", "refseq_ac": [ { "id": "NP_650858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650858", "type": "external" } ], "gene_names_uniprotkb": "psidin; CG4845", "gene_names_refseq": "CG4845; Dmel\\CG4845; Naa25; dNAA25; ird16; psidin; psid; psif", "protein_names_uniprotkb": "Phagocyte signaling-impaired protein; N-terminal acetyltransferase B complex subunit MDM20 homolog; N-terminal acetyltransferase B complex subunit NAA25 homolog", "protein_names_refseq": "CG4845-PA; N(alpha)-acetyltransferase 25; immune response deficient 16; phagocyte signaling impaired; psidin-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4845)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;17208189", "class_list": "", "function": "Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of proteins beginning with Met-Asp or Met-Glu (By similarity). Has 2 roles in the larval immune response: required both for the phagocytic degradation of internalized bacteria and for the induction of Defensin in the fat body. Within the phagocytic blood cells, has a role in detection of infection and activation of the humoral immune response., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7YTX6", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0010698 acetyltransferase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:1990761 growth cone lamellipodium;GO:0005764 lysosome;GO:0043005 neuron projection;GO:0031416 NatB complex", "go_biological_process": "GO:0002253 activation of immune response;GO:0006911 phagocytosis, engulfment;GO:0006955 immune response;GO:0045087 innate immune response;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VDQ7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VDT6-1", "uniprot_id": [ { "id": "MRM2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VDT6", "type": "external" } ], "mass": 28137.0, "length": 250, "protein_name": "rRNA methyltransferase 2, mitochondrial", "gene_name": "Mrm2", "organism": "Fruit fly", "refseq_name": "mitochondrial rRNA methyltransferase 2", "refseq_ac": [ { "id": "NP_650835", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650835", "type": "external" } ], "gene_names_uniprotkb": "Mrm2; CG11447", "gene_names_refseq": "CG11447; DmMRM2; Dmel\\CG11447; Mrm2", "protein_names_uniprotkb": "rRNA methyltransferase 2, mitochondrial; 2.1.1.-; dmMRM2; rRNA (uridine-2'-O)-methyltransferase", "protein_names_refseq": "CG11447-PA; Mrm2-PA; mitochondrial rRNA methyltransferase 2", "tax_id": 7227, "disease": "mitochondrial DNA depletion syndrome 17 (Disease Ontology:DOID:0070448); MELAS syndrome (Disease Ontology:DOID:3687)", "pathway": " (dme:Dmel_CG11447)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;25009282;35177605", "class_list": "", "function": "S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1579 (Um1579) in the mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. This activity may require prior 2'-O-methylguanosine modification at position 1580 (Gm1580) by MRM3. Essential for late-stage assembly of mtLSU required for efficient translation of mitochondrial DNA encoded proteins; methyltransferase activity is not required for this function. Essential for mitochondrial respiratory function., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006364 rRNA processing;GO:1902775 mitochondrial large ribosomal subunit assembly;GO:0001510 RNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VDT6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VE01-1", "uniprot_id": [ { "id": "C12A5_DROME", "url": "https://www.uniprot.org/uniprot/Q9VE01", "type": "external" } ], "mass": 61355.0, "length": 536, "protein_name": "Probable cytochrome P450 12a5, mitochondrial", "gene_name": "Cyp12a5", "organism": "Fruit fly", "refseq_name": "cytochrome P450 12a5", "refseq_ac": [ { "id": "NP_650782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650782", "type": "external" } ], "gene_names_uniprotkb": "Cyp12a5; CG11821", "gene_names_refseq": "12a5; CG11821; CYP12A5; CYP12a5; Cyp12A5; Cyp12a5; Dmel\\CG11821", "protein_names_uniprotkb": "Probable cytochrome P450 12a5, mitochondrial; 1.14.-.-; CYPXIIA5", "protein_names_refseq": "CG11821-PA; Cyp12a5-PA; cytochrome P450 12a5; cytochrome P450", "tax_id": 7227, "disease": "colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); infantile hypercalcemia 1 (Disease Ontology:DOID:0061136); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); childhood-onset asthma (Disease Ontology:DOID:0080815); vitamin D-dependent rickets type 1A (Disease Ontology:DOID:0080886); pre-eclampsia (Disease Ontology:DOID:10591); rickets (Disease Ontology:DOID:10609); gestational diabetes (Disease Ontology:DOID:11714); lung cancer (Disease Ontology:DOID:1324); extrahepatic cholestasis (Disease Ontology:DOID:13619); alcohol use disorder (Disease Ontology:DOID:1574); rectum cancer (Disease Ontology:DOID:1993); hepatitis B (Disease Ontology:DOID:2043); colon cancer (Disease Ontology:DOID:219); colon adenocarcinoma (Disease Ontology:DOID:234); nephrosis (Disease Ontology:DOID:2527); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); acute kidney failure (Disease Ontology:DOID:3021); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); breast carcinoma (Disease Ontology:DOID:3459); ovary adenocarcinoma (Disease Ontology:DOID:3713); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); lung carcinoma (Disease Ontology:DOID:3905); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); cerebrotendinous xanthomatosis (Disease Ontology:DOID:4810); esophagus adenocarcinoma (Disease Ontology:DOID:4914); esophageal cancer (Disease Ontology:DOID:5041); lung small cell carcinoma (Disease Ontology:DOID:5409); ulcerative colitis (Disease Ontology:DOID:8577); Wilson disease (Disease Ontology:DOID:893); colorectal cancer (Disease Ontology:DOID:9256); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG11821)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;15663776", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 37, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6SEI2;Q8MQI5", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0031966 mitochondrial membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VE01-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VEB4-1", "uniprot_id": [ { "id": "MTEF5_DROME", "url": "https://www.uniprot.org/uniprot/Q9VEB4", "type": "external" } ], "mass": 64830.0, "length": 560, "protein_name": "Transcription termination factor 5, mitochondrial", "gene_name": "mTerf5", "organism": "Fruit fly", "refseq_name": "mitochondrial transcription termination factor 5", "refseq_ac": [ { "id": "NP_650693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650693", "type": "external" } ], "gene_names_uniprotkb": "mTerf5; CG7175", "gene_names_refseq": "CG7175; D-MTERF5; Dmel\\CG7175; mTerf5", "protein_names_uniprotkb": "Transcription termination factor 5, mitochondrial; Mitochondrial transcription termination factor 5; mTerf5", "protein_names_refseq": "CG7175-PA; mTerf5-PA; mitochondrial transcription termination factor 5", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7175)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;22784680;24068965", "class_list": "", "function": "Binds promoter DNA and regulates initiation of transcription (PubMed:22784680, PubMed:24068965). Regulates mitochondrial replication and transcription (PubMed:22784680, PubMed:24068965). Required for normal topology and maintenance of mitochondrial DNA (mtDNA) levels (PubMed:22784680, PubMed:24068965). Regulates mtDNA replication by re-activating replication after replication pausing (PubMed:24068965). Likely to regulate replication pausing by coordinating with the mitochondrial termination factor mTTF which promotes replication pausing (PubMed:24068965). Their function in replication pausing prevents unregulated replication that may occur for example by collisions between the machineries of DNA replication and transcription during mtDNA synthesis (PubMed:24068965). This ensures the incorporation of RNA transcripts into replication intermediates at the replication fork and allows for proper fork progression (PubMed:24068965). Possibly functions downstream of Dref which activates genes involved in mtDNA replication and maintenance (PubMed:24068965)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0140416 transcription regulator inhibitor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006393 termination of mitochondrial transcription;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VEB4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VEG3-1", "uniprot_id": [ { "id": "Q9VEG3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VEG3", "type": "external" } ], "mass": 13633.0, "length": 121, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG14321", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_650650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650650", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG14321; CG14321; Dmel_CG14321", "gene_names_refseq": "CG14321; Dmel\\CG14321", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG14321-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14321)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VEG3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VEG9-1", "uniprot_id": [ { "id": "NRM_DROME", "url": "https://www.uniprot.org/uniprot/Q9VEG9", "type": "external" } ], "mass": 28570.0, "length": 253, "protein_name": "Nurim homolog", "gene_name": "nrm", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_650646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650646", "type": "external" } ], "gene_names_uniprotkb": "nrm; CG7655", "gene_names_refseq": "CG7655; Dmel\\CG7655", "protein_names_uniprotkb": "Nurim homolog; Nuclear envelope membrane protein; Nuclear rim protein", "protein_names_refseq": "CG7655-PA; uncharacterized protein", "tax_id": 7227, "disease": "alcohol dependence (Disease Ontology:DOID:0050741)", "pathway": " (dme:Dmel_CG7655)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0031965 nuclear membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VEG9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VEM1-1", "uniprot_id": [ { "id": "Q9VEM1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VEM1", "type": "external" } ], "mass": 31659.0, "length": 280, "protein_name": "3.2.2.27; Single-strand-selective monofunctional uracil-DNA glycosylase", "gene_name": "Smug", "organism": "Fruit fly", "refseq_name": "Single-strand-selective monofunctional uracil-DNA glycosylase", "refseq_ac": [ { "id": "NP_650609", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650609", "type": "external" } ], "gene_names_uniprotkb": "Smug; CG5285_Dm_7300236; CG5285; Dmel\\CG5285; Dmel_CG5285; SMUG1; SMUG; dmSMUG1; ssUDG", "gene_names_refseq": "CG5285_Dm_7300236; CG5285; Dmel\\CG5285; SMUG1; SMUG; Smug; dmSMUG1; ssUDG", "protein_names_uniprotkb": "3.2.2.27; Single-strand-selective monofunctional uracil-DNA glycosylase", "protein_names_refseq": "CG5285-PA; Single-strand-selective monofunctional uracil-DNA glycosylase; Smug-PA; single-strand-specific UDG; single-strand-specific monofunctional uracil-DNA glycosylase 1; uracil-DNA glycosylase", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5285); (R-DME-110329); (R-DME-110357)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.2.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.27", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0004844 uracil DNA N-glycosylase activity;GO:0017065 single-strand selective uracil DNA N-glycosylase activity;GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006284 base-excision repair", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VEM1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VEP1-1", "uniprot_id": [ { "id": "TRM71_DROME", "url": "https://www.uniprot.org/uniprot/Q9VEP1", "type": "external" } ], "mass": 33402.0, "length": 302, "protein_name": "tRNA (cytidine(32)-2'-O)-methyltransferase", "gene_name": "Trm7-32", "organism": "Fruit fly", "refseq_name": "tRNA methyltransferase 7-32", "refseq_ac": [ { "id": "NP_650590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650590", "type": "external" } ], "gene_names_uniprotkb": "Trm7-32; CG5220", "gene_names_refseq": "CG5220; Dm TRM7; Dmel\\CG5220; Trm7-32; Trm7_32; dTrm7_32", "protein_names_uniprotkb": "tRNA (cytidine(32)-2'-O)-methyltransferase; 2'-O-ribose RNA methyltransferase TRM7 homolog 1; 2.1.1.-; tRNA methyltransferase 7-32", "protein_names_refseq": "CG5220-PA; Trm7-32-PA; tRNA methyltransferase 7-32", "tax_id": 7227, "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); non-syndromic X-linked intellectual disability 9 (Disease Ontology:DOID:0112034)", "pathway": " (dme:Dmel_CG5220)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;25404562;31943105;36720500", "class_list": "", "function": "Methylates the 2'-O-ribose of nucleotides at position 32 of the tRNA anticodon loop of substrate tRNAs (PubMed:25404562, PubMed:31943105). Plays a role in neurogenesis (PubMed:36720500). Requisite for RNA-mediated gene silencing (PubMed:31943105). May modify position 32 in tRNA(Arg(ACG)), tRNA(Gln(CUG)), tRNA(Gln(UUG)), tRNA(Gln(CUC)), tRNA(Leu(CAA)), tRNA(Leu(CAG)), tRNA(Phe(GAA)), tRNA(Trp(CCA)), tRNA(Val(TAC)), tRNA(Val(CAC)), and tRNA(Val(AAC)) (PubMed:31943105)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q53YH6", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0008175 tRNA methyltransferase activity;GO:1904047 S-adenosyl-L-methionine binding;GO:0106339 tRNA (cytidine(32)-2'-O)-methyltransferase activity;GO:0106340 tRNA (guanosine(34)-2'-O)-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002128 tRNA nucleoside ribose methylation;GO:0030488 tRNA methylation;GO:0022008 neurogenesis;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VEP1-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VER7-1", "uniprot_id": [ { "id": "Q9VER7_DROME", "url": "https://www.uniprot.org/uniprot/Q9VER7", "type": "external" } ], "mass": 35848.0, "length": 308, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG14907", "organism": "Fruit fly", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "Dmel\\CG14907; CG14907; Dmel_CG14907", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14907)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VER7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VF34-1", "uniprot_id": [ { "id": "Q9VF34_DROME", "url": "https://www.uniprot.org/uniprot/Q9VF34", "type": "external" } ], "mass": 43897.0, "length": 382, "protein_name": "Fibrinogen C-terminal domain-containing protein", "gene_name": "FBpp0082632", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_650493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650493", "type": "external" } ], "gene_names_uniprotkb": "FBpp0082632; AAF55227; CG9593; Dmel\\CG9593; Dmel_CG9593", "gene_names_refseq": "AAF55227; CG9593; Dmel\\CG9593; FBpp0082632", "protein_names_uniprotkb": "Fibrinogen C-terminal domain-containing protein", "protein_names_refseq": "CG9593-PB; Fibrinogen-related protein; uncharacterized protein", "tax_id": 7227, "disease": "autoimmune glomerulonephritis (Disease Ontology:DOID:0040094); stroke (Disease Ontology:DOID:0051061); thrombosis (Disease Ontology:DOID:0060903); cardiovascular system disease (Disease Ontology:DOID:1287); congenital afibrinogenemia (Disease Ontology:DOID:2236); coronary artery disease (Disease Ontology:DOID:3393); carotid artery disease (Disease Ontology:DOID:3407); pancreatitis (Disease Ontology:DOID:4989); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); pulmonary embolism (Disease Ontology:DOID:9477)", "pathway": " (dme:Dmel_CG9593)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 12, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030297 transmembrane receptor protein tyrosine kinase activator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VF34-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VF89-1", "uniprot_id": [ { "id": "RM09_DROME", "url": "https://www.uniprot.org/uniprot/Q9VF89", "type": "external" } ], "mass": 28805.0, "length": 248, "protein_name": "Large ribosomal subunit protein bL9m", "gene_name": "mRpL9", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein L9", "refseq_ac": [ { "id": "NP_524363", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524363", "type": "external" } ], "gene_names_uniprotkb": "mRpL9; CG4923", "gene_names_refseq": "CG31478; CG4923; Dmel\\CG31478; L9; mRPL9; mRpL9", "protein_names_uniprotkb": "Large ribosomal subunit protein bL9m; 39S ribosomal protein L9, mitochondrial; L9mt; MRP-L9", "protein_names_refseq": "CG31478-PA; mRpL9-PA; mitochondrial ribosomal protein L9", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31478); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10731132;11279069;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VF89-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VFB9-1", "uniprot_id": [ { "id": "Q9VFB9_DROME", "url": "https://www.uniprot.org/uniprot/Q9VFB9", "type": "external" } ], "mass": 71859.0, "length": 639, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG6654", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_650429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650429", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG6654; CG6654; Dmel_CG6654", "gene_names_refseq": "CG6654; Dmel\\CG6654", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG6654-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6654)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8T0T1", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VFB9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VFN2-1", "uniprot_id": [ { "id": "OR88A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VFN2", "type": "external" } ], "mass": 47088.0, "length": 401, "protein_name": "Odorant receptor 88a", "gene_name": "Or88a", "organism": "Fruit fly", "refseq_name": "odorant receptor 88a", "refseq_ac": [ { "id": "NP_524348", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524348", "type": "external" } ], "gene_names_uniprotkb": "Or88a; CG14360", "gene_names_refseq": "88A.1; 88a; CG14360; DOR99; DmOr88a; Dmel\\CG14360; OR88a; Or88a; or88a", "protein_names_uniprotkb": "Odorant receptor 88a", "protein_names_refseq": "CG14360-PA; Or88a-PA; odorant receptor 88a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14360)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;10943836;12537572;16615896", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VFN2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VFS2-1", "uniprot_id": [ { "id": "NINAB_DROME", "url": "https://www.uniprot.org/uniprot/Q9VFS2", "type": "external" } ], "mass": 69932.0, "length": 620, "protein_name": "Carotenoid isomerooxygenase", "gene_name": "ninaB", "organism": "Fruit fly", "refseq_name": "neither inactivation nor afterpotential B", "refseq_ac": [ { "id": "NP_650307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650307", "type": "external" } ], "gene_names_uniprotkb": "ninaB; CG9347; beta-diox", "gene_names_refseq": "CG9347; DRPE65; Dmel\\CG9347; RPE65; anon-WO0148162.1; anon-WO0148163.1; beta-diox; ninaB", "protein_names_uniprotkb": "Carotenoid isomerooxygenase; 1.13.11.65; Beta-carotene 15,15'-monooxygenase and retinoid isomerase; Beta-carotene dioxygenase and retinoid isomerase; Neither inactivation nor afterpotential mutant B", "protein_names_refseq": "CG9347-PA; beta-carotene dioxygenase; neither inactivation nor afterpotential B; ninaB-PA", "tax_id": 7227, "disease": "Leber congenital amaurosis 2 (Disease Ontology:DOID:0110016); retinitis pigmentosa 20 (Disease Ontology:DOID:0110353); retinitis pigmentosa 87 (Disease Ontology:DOID:0112144); retinitis pigmentosa (Disease Ontology:DOID:10584); squamous cell carcinoma (Disease Ontology:DOID:1749); basal cell carcinoma (Disease Ontology:DOID:2513)", "pathway": " (dme:Dmel_CG9347); (R-DME-2453902); (R-DME-975634)", "pathway_count": 3, "publication_count": 9, "publication_id_list": "10731132;10766819;11158606;12537569;12537572;14982930;17344064;17452532;19889630", "class_list": "", "function": "Catalyzes the oxidative cleavage at the 15,15'-double bond of carotenoids and the simultaneous all-trans to 11-cis isomerization of one cleavage product. Carotenoids like 11-cis retinal can promote visual pigment biogenesis in the dark. Essential for the biosynthesis of the 3-hydroxyretinal chromophore of rhodopsin from zeaxanthin and for proper photoreceptor development. Also essential for larval light perception., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 6, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.13.11.65", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.65", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003834 beta-carotene 15,15'-dioxygenase activity;GO:0010436 carotenoid dioxygenase activity;GO:0004497 monooxygenase activity;GO:0106422 carotenoid isomerooxygenase activity", "go_cellular_component": "", "go_biological_process": "GO:0042572 retinol metabolic process;GO:0007603 phototransduction, visible light;GO:0042574 retinal metabolic process;GO:0007602 phototransduction;GO:0035238 vitamin A biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9VFS2-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VFX1-1", "uniprot_id": [ { "id": "WNT8_DROME", "url": "https://www.uniprot.org/uniprot/Q9VFX1", "type": "external" } ], "mass": 34777.0, "length": 309, "protein_name": "Wnt inhibitor of Dorsal protein", "gene_name": "wntD", "organism": "Fruit fly", "refseq_name": "wnt inhibitor of dorsal", "refseq_ac": [ { "id": "NP_650272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650272", "type": "external" } ], "gene_names_uniprotkb": "wntD; CG8458; Wnt8", "gene_names_refseq": "CG8458; DWnt-8; DWnt8; DWntD; Dm DWnt8; Dmel\\CG8458; Dwnt-8; Dwnt-D; Dwnt8; Wnt8; WntD; Wntd; wnt8; wntD", "protein_names_uniprotkb": "Wnt inhibitor of Dorsal protein; Protein Wnt-8; dWnt-8", "protein_names_refseq": "CG8458-PA; wnt inhibitor of dorsal; wntD-PA", "tax_id": 7227, "disease": "Hirschsprung's disease (Disease Ontology:DOID:10487)", "pathway": " (dme:Dmel_CG8458); (R-DME-3238698); (R-DME-4641262)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;12717451;18430724;23791946", "class_list": "", "function": "Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0050830 defense response to Gram-positive bacterium;GO:0030182 neuron differentiation;GO:0060070 canonical Wnt signaling pathway;GO:0008354 germ cell migration;GO:0035567 non-canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VFX1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VG08-1", "uniprot_id": [ { "id": "YELF2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VG08", "type": "external" } ], "mass": 51029.0, "length": 452, "protein_name": "L-dopachrome tautomerase yellow-f2", "gene_name": "yellow-f2", "organism": "Fruit fly", "refseq_name": "yellow-f2", "refseq_ac": [ { "id": "NP_650247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650247", "type": "external" } ], "gene_names_uniprotkb": "yellow-f2; CG8063", "gene_names_refseq": "CG8063; DCDT; DI; Dmel\\CG8063; Yellow-f2; yel-f2; yellow-f2", "protein_names_uniprotkb": "L-dopachrome tautomerase yellow-f2; 5.3.3.12", "protein_names_refseq": "CG8063-PA; dopachrome decarboxylase/tautomerase; dopachrome isomerase; yellow-f2-PA; yellow-f2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8063)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12164780;12537569;12537572", "class_list": "", "function": "Tautomerization of L-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI). Also catalyzes the tautomerization of the methyl ester of L-dopachrome and dopamine chrome. May play a role in melanization reactions during late pupal and adult stages., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q95SK7", "ec_number_list": [ { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" } ], "go_molecular_function": "GO:0004167 dopachrome isomerase activity;GO:0106417 dopaminechrome tautomerase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0048066 developmental pigmentation;GO:0006583 melanin biosynthetic process from tyrosine;GO:0042435 indole-containing compound biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VG08-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VG58-1", "uniprot_id": [ { "id": "HSP74_DROME", "url": "https://www.uniprot.org/uniprot/Q9VG58", "type": "external" } ], "mass": 70253.0, "length": 641, "protein_name": "Major heat shock 70 kDa protein Bbb", "gene_name": "Hsp70Bbb", "organism": "Fruit fly", "refseq_name": "heat shock protein 70 Bbb", "refseq_ac": [ { "id": "NP_788663", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788663", "type": "external" } ], "gene_names_uniprotkb": "Hsp70Bbb; CG5834", "gene_names_refseq": "CG31354; CG5834; Dm-hsp70; Dmel\\CG5834; HSP70Bbb; HSP70cA5; HSP70; Hsp-70; Hsp70Bbb; Hsp70Bb; Hsp70B; Hsp70; dHsp70; hsp70Bb-prime; hsp70B; hsp70bBb; hsp70bbb; hsp70", "protein_names_uniprotkb": "Major heat shock 70 kDa protein Bbb; HSP70-87C1; Heat shock protein 70Bbb", "protein_names_refseq": "70 kDa heat shock protein, cytosolic A 5; CG5834-PA; Hsp70Bbb-PA; heat shock protein 70 Bbb; heat shock protein 70; heat-shock protein 70", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5834)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;11493638;12537572;18344983", "class_list": "", "function": "Stress-response chaperone protein that prevents toxic aggregation of proteins., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0001666 response to hypoxia;GO:0009408 response to heat;GO:0042026 protein refolding;GO:0035080 heat shock-mediated polytene chromosome puffing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VG58-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VG82-1", "uniprot_id": [ { "id": "CP9F2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VG82", "type": "external" } ], "mass": 60279.0, "length": 516, "protein_name": "Probable cytochrome P450 9f2", "gene_name": "Cyp9f2", "organism": "Fruit fly", "refseq_name": "cytochrome P450 9f2", "refseq_ac": [ { "id": "NP_650189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650189", "type": "external" } ], "gene_names_uniprotkb": "Cyp9f2; CG11466", "gene_names_refseq": "9f2; CG11466; CYP9F2; Cyp 9f2; Cyp9F2; Cyp9f2; Dmel\\CG11466; anon-EST:Posey150", "protein_names_uniprotkb": "Probable cytochrome P450 9f2; 1.14.-.-; CYPIXF2", "protein_names_refseq": "CG11466-PA; Cyp9f2-PA; cytochrome P450 9f2; cytochrome P450", "tax_id": 7227, "disease": "alcohol dependence (Disease Ontology:DOID:0050741); thrombosis (Disease Ontology:DOID:0060903); alcohol-associated liver disease (Disease Ontology:DOID:0070658); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); Ghosal hematodiaphyseal syndrome (Disease Ontology:DOID:0112251); prostate cancer (Disease Ontology:DOID:10283); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); essential hypertension (Disease Ontology:DOID:10825); membranous glomerulonephritis (Disease Ontology:DOID:10976); hydronephrosis (Disease Ontology:DOID:11111); cholestasis (Disease Ontology:DOID:13580); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); arteriosclerosis (Disease Ontology:DOID:2349); glomerulonephritis (Disease Ontology:DOID:2921); familial Mediterranean fever (Disease Ontology:DOID:2987); brain infarction (Disease Ontology:DOID:3454); cerebral infarction (Disease Ontology:DOID:3526); liver cirrhosis (Disease Ontology:DOID:5082); oral submucous fibrosis (Disease Ontology:DOID:5773); end stage renal disease (Disease Ontology:DOID:783); chronic myeloid leukemia (Disease Ontology:DOID:8552); pulmonary embolism (Disease Ontology:DOID:9477); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dme:Dmel_CG11466)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 26, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0035220 wing disc development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VG82-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VG93-1", "uniprot_id": [ { "id": "GSTD7_DROME", "url": "https://www.uniprot.org/uniprot/Q9VG93", "type": "external" } ], "mass": 25419.0, "length": 224, "protein_name": "Glutathione S-transferase D7", "gene_name": "GstD7", "organism": "Fruit fly", "refseq_name": "glutathione S transferase D7", "refseq_ac": [ { "id": "NP_525114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_525114", "type": "external" } ], "gene_names_uniprotkb": "GstD7; CG4371; GSTD7-7; gstD26", "gene_names_refseq": "CG4371; DmGST26; DmGSTD7; DmGstd7; Dmel\\CG4371; GSTD7; GstD26; GstD7; Gst; gstD26; gstD7; gstd7; gst", "protein_names_uniprotkb": "Glutathione S-transferase D7; 2.5.1.18", "protein_names_refseq": "CG4371-PA; Glutathione-S-transferase D7; GstD7-PA; glutathione S transferase D26; glutathione S transferase D7", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4371)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;22082028;7683659", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (PubMed:22082028). May be involved in detoxification (PubMed:22082028)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q4V3S1;Q9TX87", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.5.1.1", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009636 response to toxic substance;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VG93-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VG97-1", "uniprot_id": [ { "id": "GSTD3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VG97", "type": "external" } ], "mass": 22907.0, "length": 199, "protein_name": "Inactive glutathione S-transferase D3", "gene_name": "GstD3", "organism": "Fruit fly", "refseq_name": "glutathione S transferase D3", "refseq_ac": [ { "id": "NP_788656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788656", "type": "external" } ], "gene_names_uniprotkb": "GstD3; CG4381; GSTD3-3; gstD22", "gene_names_refseq": "BcDNA:LP11313; CG4381; D3; DmGST22; DmGSTD3; Dmel\\CG4381; GST-D3; GSTD3; GstD22; GstD3; Gst; gstD22; gstD3; gstd3; gst", "protein_names_uniprotkb": "Inactive glutathione S-transferase D3", "protein_names_refseq": "CG4381-PA; Glutathione-S-transferase D3; GstD3-PA; glutathione S transferase D22; glutathione S transferase D3", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4381)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;22082028;7683659", "class_list": "", "function": "Has no glutathione S-transferase activity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MT68", "ec_number_list": [], "go_molecular_function": "GO:0003824 catalytic activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VG97-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VGA1-1", "uniprot_id": [ { "id": "Q9VGA1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VGA1", "type": "external" } ], "mass": 24593.0, "length": 210, "protein_name": "2.5.1.18; Glutathione S transferase D10, isoform A; Glutathione S transferase D10, isoform B", "gene_name": "GstD10", "organism": "Fruit fly", "refseq_name": "glutathione S transferase D10, isoform B", "refseq_ac": [ { "id": "NP_001287302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287302", "type": "external" } ], "gene_names_uniprotkb": "GstD10; CG17392; CG18548; DmGSTD10; Dmel\\CG18548; Dmel_CG18548; GSTD10; gstd10", "gene_names_refseq": "CG17392; CG18548; DmGSTD10; Dmel\\CG18548; GSTD10; GstD10; gstd10", "protein_names_uniprotkb": "2.5.1.18; Glutathione S transferase D10, isoform A; Glutathione S transferase D10, isoform B", "protein_names_refseq": "CG18548-PB; GstD10-PB; glutathione S transferase D10, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18548)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;22475449;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004364 glutathione transferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VGA1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VGG5-1", "uniprot_id": [ { "id": "CAD87_DROME", "url": "https://www.uniprot.org/uniprot/Q9VGG5", "type": "external" } ], "mass": 217557.0, "length": 1975, "protein_name": "Cadherin-87A", "gene_name": "Cad87A", "organism": "Fruit fly", "refseq_name": "cadherin 87A", "refseq_ac": [ { "id": "NP_731649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_731649", "type": "external" } ], "gene_names_uniprotkb": "Cad87A; CG6977", "gene_names_refseq": "CG6977; CT21611; Cad87A; Cad87; DCad87A; Dmel\\CG6977", "protein_names_uniprotkb": "Cadherin-87A", "protein_names_refseq": "CG6977-PA; Cad87A-PA; cadherin 87A", "tax_id": 7227, "disease": "autosomal recessive nonsyndromic deafness (Disease Ontology:DOID:0050565); autosomal recessive nonsyndromic deafness 12 (Disease Ontology:DOID:0110467); Usher syndrome type 1D (Disease Ontology:DOID:0110831); pituitary adenoma 5 (Disease Ontology:DOID:0112008)", "pathway": " (dme:Dmel_CG6977); (R-DME-114608); (R-DME-8980692)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;17893096", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells (By similarity)., [UniProtKB]", "predicted_glycosites": 15, "predicted_n_glycosites": 14, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 17, "binding_glycan_count": 0, "secondary_ac_list": "Q8MQL5", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0044331 cell-cell adhesion mediated by cadherin", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VGG5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VGG6-1", "uniprot_id": [ { "id": "IDLC_DROME", "url": "https://www.uniprot.org/uniprot/Q9VGG6", "type": "external" } ], "mass": 28797.0, "length": 250, "protein_name": "Putative inner dynein arm light chain, axonemal", "gene_name": "Dnali1", "organism": "Fruit fly", "refseq_name": "dynein axonemal light intermediate chain 1", "refseq_ac": [ { "id": "NP_650128", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650128", "type": "external" } ], "gene_names_uniprotkb": "Dnali1; CG6971", "gene_names_refseq": "CG6971; DNALI1; Dmel\\CG6971; Dnali1; IDA-Dnali1; anon-WO0140519.67", "protein_names_uniprotkb": "Putative inner dynein arm light chain, axonemal", "protein_names_refseq": "CG6971-PA; Dnali1-PA; dynein axonemal light intermediate chain 1", "tax_id": 7227, "disease": "spermatogenic failure 83 (Disease Ontology:DOID:0070582)", "pathway": " (dme:Dmel_CG6971)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;16951084", "class_list": "", "function": "May play a dynamic role in flagellar motility., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0AMZ0", "ec_number_list": [], "go_molecular_function": "GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0005930 axoneme;GO:0097546 ciliary base;GO:0036156 inner dynein arm;GO:0120293 dynein axonemal particle", "go_biological_process": "GO:0003341 cilium movement;GO:0036159 inner dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VGG6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VGH2-1", "uniprot_id": [ { "id": "Q9VGH2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VGH2", "type": "external" } ], "mass": 48056.0, "length": 425, "protein_name": "LRRCT domain-containing protein", "gene_name": "6959", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform C", "refseq_ac": [ { "id": "NP_001138037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138037", "type": "external" } ], "gene_names_uniprotkb": "6959; CG6959; CT21563; Dmel\\CG6959; Dmel_CG6959", "gene_names_refseq": "6959; CG6959; CT21563; Dmel\\CG6959", "protein_names_uniprotkb": "LRRCT domain-containing protein", "protein_names_refseq": "CG6959-PC; connectin-like; uncharacterized protein, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6959)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0071944 cell periphery", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VGH2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VGL8-1", "uniprot_id": [ { "id": "TBWKD_DROME", "url": "https://www.uniprot.org/uniprot/Q9VGL8", "type": "external" } ], "mass": 42051.0, "length": 363, "protein_name": "TBC1 domain family member whacked", "gene_name": "wkd", "organism": "Fruit fly", "refseq_name": "whacked, isoform A", "refseq_ac": [ { "id": "NP_650089", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_650089", "type": "external" } ], "gene_names_uniprotkb": "wkd; CG5344", "gene_names_refseq": "CG5344; Dmel\\CG5344; Wkd; cg5344; wkd", "protein_names_uniprotkb": "TBC1 domain family member whacked", "protein_names_refseq": "CG5344-PA; whacked, isoform A; whacked; wkd-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5344); (R-DME-6798695); (R-DME-8854214)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10731132;12537572;22407366", "class_list": "", "function": "Essential for ensuring the polarized growth of tracheal seamless tubes. During seamless tube morphogenesis, likely to act as a GTPase-activating protein (GAP) for Rab35 to regulate vesicle trafficking from the recycling endosomes to the lumenal apical membrane to ensure the polarized dynein motor complex-dependent growth of seamless tubes along the proximodistal axis in tracheal terminal cells. When the terminal branch lumen is growing, Rab35-GTP is active and likely directs the transport of apical membrane vesicles from the soma to the distal tip of elongating terminal cell branches thus providing a continuous supply of apical membrane components as the lumen grows. Whereas when Rab35-GDP is inactivated, presumably by this GAP, apical membrane vesicles are transported to a central location adjacent to the terminal cell nucleus., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0098592 cytoplasmic side of apical plasma membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle;GO:0030175 filopodium", "go_biological_process": "GO:0042147 retrograde transport, endosome to Golgi;GO:0010085 polarity specification of proximal/distal axis;GO:0035149 lumen formation, open tracheal system", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VGL8-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VGY5-1", "uniprot_id": [ { "id": "MET15_DROME", "url": "https://www.uniprot.org/uniprot/Q9VGY5", "type": "external" } ], "mass": 39703.0, "length": 356, "protein_name": "Probable methyltransferase-like protein 15 homolog", "gene_name": "CG14683", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_788632", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788632", "type": "external" } ], "gene_names_uniprotkb": "CG14683", "gene_names_refseq": "CG14683; Dmel\\CG14683; METTL15", "protein_names_uniprotkb": "Probable methyltransferase-like protein 15 homolog; 2.1.1.-", "protein_names_refseq": "CG14683-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14683)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Probable S-adenosyl-L-methionine-dependent methyltransferase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0071424 rRNA (cytosine-N4-)-methyltransferase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0070475 rRNA base methylation;GO:0180026 mitochondrial small ribosomal subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VGY5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VH14-1", "uniprot_id": [ { "id": "TIMP_DROME", "url": "https://www.uniprot.org/uniprot/Q9VH14", "type": "external" } ], "mass": 23980.0, "length": 210, "protein_name": "Tissue inhibitor of metalloproteinase", "gene_name": "Timp", "organism": "Fruit fly", "refseq_name": "tissue inhibitor of metalloproteases", "refseq_ac": [ { "id": "NP_731461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_731461", "type": "external" } ], "gene_names_uniprotkb": "Timp; CG6281", "gene_names_refseq": "CG6281; DTIMP; Dmel\\CG6281; Dtimp; TIMP1; TIMP; Timp; dTIMP; timp", "protein_names_uniprotkb": "Tissue inhibitor of metalloproteinase", "protein_names_refseq": "CG6281-PB; Timp-PB; tissue inhibitor of metalloproteases; tissue inhibitor of metalloproteinases", "tax_id": 7227, "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); stroke (Disease Ontology:DOID:0051061); ductal carcinoma in situ (Disease Ontology:DOID:0060074); congenital anomalies of the kidney and urinary tract 2 (Disease Ontology:DOID:0080207); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); Sorsby's fundus dystrophy (Disease Ontology:DOID:0090114); prostate cancer (Disease Ontology:DOID:10283); adrenoleukodystrophy (Disease Ontology:DOID:10588); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); renal hypertension (Disease Ontology:DOID:1073); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); intracranial aneurysm (Disease Ontology:DOID:10941); urinary bladder cancer (Disease Ontology:DOID:11054); heart disease (Disease Ontology:DOID:114); sciatic neuropathy (Disease Ontology:DOID:11446); Duchenne muscular dystrophy (Disease Ontology:DOID:11723); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); Huntington's disease (Disease Ontology:DOID:12858); dilated cardiomyopathy (Disease Ontology:DOID:12930); Moyamoya disease (Disease Ontology:DOID:13099); Kawasaki disease (Disease Ontology:DOID:13378); cholestasis (Disease Ontology:DOID:13580); endometrial cancer (Disease Ontology:DOID:1380); thoracic aortic aneurysm (Disease Ontology:DOID:14004); Down syndrome (Disease Ontology:DOID:14250); Marfan syndrome (Disease Ontology:DOID:14323); cystic fibrosis (Disease Ontology:DOID:1485); breast cancer (Disease Ontology:DOID:1612); vascular disease (Disease Ontology:DOID:178); preretinal fibrosis (Disease Ontology:DOID:2006); nephroblastoma (Disease Ontology:DOID:2154); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); ovarian cancer (Disease Ontology:DOID:2394); transitional cell carcinoma (Disease Ontology:DOID:2671); endometrial carcinoma (Disease Ontology:DOID:2871); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); breast carcinoma (Disease Ontology:DOID:3459); choriocarcinoma (Disease Ontology:DOID:3594); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); pulmonary fibrosis (Disease Ontology:DOID:3770); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); ovarian carcinoma (Disease Ontology:DOID:4001); cervical cancer (Disease Ontology:DOID:4362); renal cell carcinoma (Disease Ontology:DOID:4450); congestive heart failure (Disease Ontology:DOID:6000); abdominal aortic aneurysm (Disease Ontology:DOID:7693); prostate carcinoma in situ (Disease Ontology:DOID:8634); degenerative disc disease (Disease Ontology:DOID:90); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG6281)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10198170;10731132;10961449;12537569;12537572;14567681;16962574;17301221;26808525", "class_list": "", "function": "Metalloproteinase inhibitor that acts on both matrix metalloproteinases Mmp1 and Mmp2 in vitro (PubMed:14567681). Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor (By similarity). Required for wing maturation which is the final step in morphogenesis of the adult fly (PubMed:16962574). Involved in the negative regulation of developmental tissue invasion for imaginal disk eversion during metamorphosis by inhibiting Mmp-mediated basement membrane (BM) degradation (PubMed:17301221). Required for oogenesis and for the long-term maintainance of germarial structure and shape in the adult ovaries. Required for maintaining composition and biophysical properties of the extracellular matrix (ECM), and for the normal organization and cyst production of the germline stem cell (GSC) niche (PubMed:26808525)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 56, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V2N5;O96747", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0030425 dendrite;GO:0031012 extracellular matrix", "go_biological_process": "GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:0007155 cell adhesion;GO:0048477 oogenesis;GO:0071711 basement membrane organization;GO:0060232 delamination", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9VH14-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VH19-1", "uniprot_id": [ { "id": "LMLN_DROME", "url": "https://www.uniprot.org/uniprot/Q9VH19", "type": "external" } ], "mass": 76978.0, "length": 683, "protein_name": "Leishmanolysin-like peptidase", "gene_name": "Invadolysin", "organism": "Fruit fly", "refseq_name": "invadolysin", "refseq_ac": [ { "id": "NP_652072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_652072", "type": "external" } ], "gene_names_uniprotkb": "Invadolysin; CG3953; l(3)IX-14", "gene_names_refseq": "CG3953; DmIX-14; Dmel\\CG3953; IX-14; Invadolysin; invadolysin; inv; l(3)IX-14; l(3)SG34", "protein_names_uniprotkb": "Leishmanolysin-like peptidase; 3.4.24.-; Invadolysin", "protein_names_refseq": "CG3953-PA; Invadolysin-PA; invadolysin; lethal (3) IX-14", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3953)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;15557119", "class_list": "", "function": "Essential for the coordination of mitotic progression, and also plays a role in cell migration., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9NH00", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006508 proteolysis;GO:0007155 cell adhesion;GO:0051301 cell division;GO:0051881 regulation of mitochondrial membrane potential", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VH19-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VH38-1", "uniprot_id": [ { "id": "TFB2M_DROME", "url": "https://www.uniprot.org/uniprot/Q9VH38", "type": "external" } ], "mass": 52175.0, "length": 452, "protein_name": "Dimethyladenosine transferase 2, mitochondrial", "gene_name": "mtTFB2", "organism": "Fruit fly", "refseq_name": "mitochondrial transcription factor B2", "refseq_ac": [ { "id": "NP_649971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649971", "type": "external" } ], "gene_names_uniprotkb": "mtTFB2; CG3910", "gene_names_refseq": "CG3910; Dmel\\CG3910; TFB2M; TFB2; d-TF2BM; d-mtTFB2; mtTFB2", "protein_names_uniprotkb": "Dimethyladenosine transferase 2, mitochondrial; 2.1.1.-; Mitochondrial 12S rRNA dimethylase 2; Mitochondrial transcription factor B2; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2; d-mtTFB2", "protein_names_refseq": "CG3910-PA; mitochondrial transcription factor B2; mtTFB2-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3910); (R-DME-163282)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;15060065", "class_list": "", "function": "Probable S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA. Also regulates mitochondrial DNA copy number. Stimulates transcription independently of the methyltransferase activity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95SS3", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity;GO:0034246 mitochondrial transcription factor activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0031167 rRNA methylation;GO:0006391 transcription initiation at mitochondrial promoter;GO:0006390 mitochondrial transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VH38-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VH39-1", "uniprot_id": [ { "id": "NDUF4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VH39", "type": "external" } ], "mass": 23705.0, "length": 203, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4", "gene_name": "NdufAF4", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_649970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649970", "type": "external" } ], "gene_names_uniprotkb": "NdufAF4; CG11722", "gene_names_refseq": "BcDNA:AT14909; CG11722; Dmel\\CG11722; dNDUFAF4", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4; NADH:ubiquinone oxidoreductase complex assembly factor 4; dNDUFAF4", "protein_names_refseq": "CG11722-PA; uncharacterized protein", "tax_id": 7227, "disease": "nuclear type mitochondrial complex I deficiency 15 (Disease Ontology:DOID:0112077)", "pathway": " (dme:Dmel_CG11722); (R-DME-6799198)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;34386730", "class_list": "", "function": "Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:34386730). Together with NdufAF3, involved in biogenesis of complex 1 modules N, Q and P-peripheral, but not the P-distal module (PubMed:34386730). Required for recruitment of the complex I assembly factor Timmdc1 to complex 1 assembly intermediates (PubMed:34386730)., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VH39-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VH70-1", "uniprot_id": [ { "id": "TOPI_DROME", "url": "https://www.uniprot.org/uniprot/Q9VH70", "type": "external" } ], "mass": 92206.0, "length": 814, "protein_name": "Testis-specific zinc finger protein topi", "gene_name": "topi", "organism": "Fruit fly", "refseq_name": "matotopetli", "refseq_ac": [ { "id": "NP_649945", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649945", "type": "external" } ], "gene_names_uniprotkb": "topi; CG8484", "gene_names_refseq": "CG8484; Dmel\\CG8484; Topi; topi", "protein_names_uniprotkb": "Testis-specific zinc finger protein topi; Protein matotopetli", "protein_names_refseq": "CG8484-PA; matotopetli; topi-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8484)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;15084455", "class_list": "", "function": "Required for male meiotic division and spermatid differentiation. Required for accumulation of aly and comr on chromatin. May function as a transcription factor., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5BHW6;Q8MZ91", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VH70-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VH95-1", "uniprot_id": [ { "id": "TEBPH_DROME", "url": "https://www.uniprot.org/uniprot/Q9VH95", "type": "external" } ], "mass": 20753.0, "length": 184, "protein_name": "Cytosolic Prostaglandin E synthase", "gene_name": "cPges", "organism": "Fruit fly", "refseq_name": "p23, isoform B", "refseq_ac": [ { "id": "NP_001247010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247010", "type": "external" } ], "gene_names_uniprotkb": "cPges; CG16817; p23", "gene_names_refseq": "CG16817; Dmel\\CG16817; YC17; cg16817; p23", "protein_names_uniprotkb": "Cytosolic Prostaglandin E synthase; 5.3.99.3; Prostaglandin E synthase 3 homolog", "protein_names_refseq": "CG16817-PB; homolog to co-chaperone p23; p23, isoform B; p23-PB", "tax_id": 7227, "disease": "breast cancer (Disease Ontology:DOID:1612); atherosclerosis (Disease Ontology:DOID:1936); oligodendroglioma (Disease Ontology:DOID:3181)", "pathway": " (dme:Dmel_CG16817); (R-DME-2162123); (R-DME-3371497); (R-DME-3371511); (R-DME-3371568); (R-DME-8937144); (R-DME-8939211); (R-DME-9018519)", "pathway_count": 8, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;17372656;18327897;38283991", "class_list": "", "function": "Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (By similarity). Through production of PGE2 may regulate the activity of non-muscle myosin II in an autocrine or paracrine fashion; this may influence border cell and nurse cell stiffness to facilitate border cell migration during oogenesis (PubMed:38283991)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A0B4K6D2;E8NH46", "ec_number_list": [ { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0051879 Hsp90 protein binding;GO:0050220 prostaglandin-E synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006457 protein folding;GO:0051131 chaperone-mediated protein complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VH95-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VHB9-1", "uniprot_id": [ { "id": "TRM44_DROME", "url": "https://www.uniprot.org/uniprot/Q9VHB9", "type": "external" } ], "mass": 59384.0, "length": 521, "protein_name": "Probable tRNA (uracil-O(2)-)-methyltransferase", "gene_name": "trmt44", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_649904", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649904", "type": "external" } ], "gene_names_uniprotkb": "trmt44; CG9386", "gene_names_refseq": "CG9386; Dmel\\CG9386; METTL19", "protein_names_uniprotkb": "Probable tRNA (uracil-O(2)-)-methyltransferase; 2.1.1.211", "protein_names_refseq": "CG9386-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9386)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.211", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.211", "type": "external" } ], "go_molecular_function": "GO:0016300 tRNA (uridine) methyltransferase activity;GO:0141101 tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0030488 tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VHB9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VHD2-1", "uniprot_id": [ { "id": "MAAI2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VHD2", "type": "external" } ], "mass": 25975.0, "length": 227, "protein_name": "Probable maleylacetoacetate isomerase 2", "gene_name": "GstZ2", "organism": "Fruit fly", "refseq_name": "glutathione S transferase Z2, isoform A", "refseq_ac": [ { "id": "NP_649895", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649895", "type": "external" } ], "gene_names_uniprotkb": "GstZ2; CG9363", "gene_names_refseq": "CG9363; Dmel\\CG9363; GSTZ2; GstZ2; cg9363; gstZ2; gstz2", "protein_names_uniprotkb": "Probable maleylacetoacetate isomerase 2; 2.5.1.18; 5.2.1.2; Glutathione S-transferase zeta 2; MAAI 2", "protein_names_refseq": "CG9363-PA; GstZ2-PA; glutathione S transferase Z2, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9363); (R-DME-156590); (R-DME-204174); (R-DME-8963684)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;22082028", "class_list": "", "function": "Catalyzes the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid in vitro. Has no glutathione thioltransferase activity with 4-hydroxynonenal (4-HNE), adrenochrome, phenethyl isothiocyanate (PEITC), 5-hydroperoxyeicosatetraenoic acid ((5S)-HpETE), prostaglandin A2 (PGA2) or 2-hydroxyethyldisulfide (HED)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "H0RNF8;H8F4P9;Q8INN9", "ec_number_list": [ { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.5.1.1", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "1.5.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.4.1", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0016034 maleylacetoacetate isomerase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006559 L-phenylalanine catabolic process;GO:0006572 L-tyrosine catabolic process;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VHD2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VHD3-1", "uniprot_id": [ { "id": "MAAI1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VHD3", "type": "external" } ], "mass": 27890.0, "length": 246, "protein_name": "Probable maleylacetoacetate isomerase 1", "gene_name": "GstZ1", "organism": "Fruit fly", "refseq_name": "glutathione S transferase Z1", "refseq_ac": [ { "id": "NP_649894", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649894", "type": "external" } ], "gene_names_uniprotkb": "GstZ1; CG9362", "gene_names_refseq": "CG9362; Dmel\\CG9362; GSTZ1; GstZ1; gstz1", "protein_names_uniprotkb": "Probable maleylacetoacetate isomerase 1; 2.5.1.18; 5.2.1.2; Glutathione S-transferase zeta 1; MAAI 1", "protein_names_refseq": "CG9362-PA; GstZ1-PA; glutathione S transferase Z1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9362)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;22082028", "class_list": "", "function": "Catalyzes the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid in vitro. Possesses low glutathione thioltransferase activity toward 4-hydroxynonenal (4-HNE). Has no glutathione thioltransferase activity with adrenochrome, phenethyl isothiocyanate (PEITC), 5-hydroperoxyeicosatetraenoic acid ((5S)-HpETE), prostaglandin A2 (PGA2) or 2-hydroxyethyldisulfide (HED)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "4.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.5.1.1", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0016034 maleylacetoacetate isomerase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006559 L-phenylalanine catabolic process;GO:0006572 L-tyrosine catabolic process;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VHD3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VHI7-1", "uniprot_id": [ { "id": "IRU_DROME", "url": "https://www.uniprot.org/uniprot/Q9VHI7", "type": "external" } ], "mass": 40319.0, "length": 380, "protein_name": "E3 ubiquitin-protein ligase Iruka", "gene_name": "Iru", "organism": "Fruit fly", "refseq_name": "iruka", "refseq_ac": [ { "id": "NP_649859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649859", "type": "external" } ], "gene_names_uniprotkb": "Iru; CG11982", "gene_names_refseq": "CG11982; Dmel\\CG11982; Iru", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Iruka; 2.3.2.27", "protein_names_refseq": "CG11982-PA; Iru-PA; iruka", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11982); (R-DME-983168)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;30503771", "class_list": "", "function": "E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates (PubMed:30503771). Recognizes miRNA-empty Ago1 and triggers its degradation via polyubiquitination independently of the Bag6 complex (PubMed:30503771). By targeting miRNA-empty Ago1, eliminates dysfunctional Ago1 not able to bind miRNA and thereby plays a role in the quality control of miRNA-mediated silencing (PubMed:30503771)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0000209 protein polyubiquitination;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VHI7-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VHJ6-1", "uniprot_id": [ { "id": "ICH_DROME", "url": "https://www.uniprot.org/uniprot/Q9VHJ6", "type": "external" } ], "mass": 62626.0, "length": 592, "protein_name": "Ichor", "gene_name": "ich", "organism": "Fruit fly", "refseq_name": "ichor, isoform B", "refseq_ac": [ { "id": "NP_001262393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262393", "type": "external" } ], "gene_names_uniprotkb": "ich; CG11966", "gene_names_refseq": "CG11966; Dmel\\CG11966; Ichor; ichorous; ich; l(3)05652", "protein_names_uniprotkb": "Ichor", "protein_names_refseq": "CG11966-PB; ich-PB; ichor, isoform B; ichorous; lethal (3) 05652", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11966)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;29309404", "class_list": "", "function": "Transcriptional activator. In tracheal terminal cells, regulates the transcription of factors involved in the formation of a mature apical extracellular matrix (aECM) which is essential for the integrity and shape of seamless tubes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0AVW9;B7FNR4;T1T717", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0060439 trachea morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VHJ6-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VHN9-1", "uniprot_id": [ { "id": "HPS5_DROME", "url": "https://www.uniprot.org/uniprot/Q9VHN9", "type": "external" } ], "mass": 93620.0, "length": 826, "protein_name": "BLOC-2 complex member HPS5 homolog", "gene_name": "p", "organism": "Fruit fly", "refseq_name": "pink, isoform B", "refseq_ac": [ { "id": "NP_001303455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303455", "type": "external" } ], "gene_names_uniprotkb": "p; CG9770; HPS5", "gene_names_refseq": "CG9770; Dmel\\CG9770; HPS5; NP_649810; dHPS5; p; snb", "protein_names_uniprotkb": "BLOC-2 complex member HPS5 homolog; Hermansky-Pudlak syndrome 5 protein homolog; Protein pink; dHPS5", "protein_names_refseq": "CG9770-PB; drosophila Hermansky-Pudlak syndrome 5 subunit; p-PB; pink, isoform B; pink-peach; sunburst", "tax_id": 7227, "disease": "Hermansky-Pudlak syndrome 5 (Disease Ontology:DOID:0060543); platelet storage pool deficiency (Disease Ontology:DOID:2223); Hermansky-Pudlak syndrome (Disease Ontology:DOID:3753)", "pathway": " (dme:Dmel_CG9770)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;17156100;17632576;9714595", "class_list": "", "function": "Has a role in the biogenesis of eye pigment granules. Eye pigment granules are specialized forms of late endosomes or lysosomes. Biogenesis of pigment granules in the eye requires molecular components required for protein delivery to lysosomes., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SXI1", "ec_number_list": [], "go_molecular_function": "GO:0031409 pigment binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031084 BLOC-2 complex", "go_biological_process": "GO:0007601 visual perception;GO:0006726 eye pigment biosynthetic process;GO:0006622 protein targeting to lysosome;GO:0048066 developmental pigmentation;GO:0006727 ommochrome biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VHN9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VHQ6-1", "uniprot_id": [ { "id": "OR85C_DROME", "url": "https://www.uniprot.org/uniprot/Q9VHQ6", "type": "external" } ], "mass": 45606.0, "length": 389, "protein_name": "Odorant receptor 85c", "gene_name": "Or85c", "organism": "Fruit fly", "refseq_name": "odorant receptor 85c", "refseq_ac": [ { "id": "NP_524280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524280", "type": "external" } ], "gene_names_uniprotkb": "Or85c; CG17911", "gene_names_refseq": "85A.3; 85c; CG17911; DOR78; Dmel\\CG17911; OR85c; Or85c", "protein_names_uniprotkb": "Odorant receptor 85c", "protein_names_refseq": "CG17911-PA; Or85c-PA; odorant receptor 85c", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17911)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;21613503", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VHQ6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VHX7-1", "uniprot_id": [ { "id": "ELOV7_DROME", "url": "https://www.uniprot.org/uniprot/Q9VHX7", "type": "external" } ], "mass": 38355.0, "length": 329, "protein_name": "Very long chain fatty acid elongase 7", "gene_name": "Elovl7", "organism": "Fruit fly", "refseq_name": "ELOVL fatty acid elongase 7", "refseq_ac": [ { "id": "NP_649754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649754", "type": "external" } ], "gene_names_uniprotkb": "Elovl7; CG2781; ELOVL", "gene_names_refseq": "CG2781; Dmel\\CG2781; ELOVL; Elovl7; dELOVL", "protein_names_uniprotkb": "Very long chain fatty acid elongase 7; 2.3.1.199; ELOVL fatty acid elongase 7; Elongation of very long chain fatty acids protein 7; Very-long-chain 3-oxoacyl-CoA synthase", "protein_names_refseq": "CG2781-PA; ELOVL fatty acid elongase 7; ELOVL fatty acid elongase; Elovl7-PA", "tax_id": 7227, "disease": "adrenoleukodystrophy (Disease Ontology:DOID:10588)", "pathway": " (dme:Dmel_CG2781); (R-DME-2046105); (R-DME-2046106); (R-DME-75876)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MS02", "ec_number_list": [ { "id": "2.3.1.199", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.199", "type": "external" } ], "go_molecular_function": "GO:0009922 fatty acid elongase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001676 long-chain fatty acid metabolic process;GO:0030148 sphingolipid biosynthetic process;GO:0030497 fatty acid elongation;GO:0034625 fatty acid elongation, monounsaturated fatty acid;GO:0034626 fatty acid elongation, polyunsaturated fatty acid", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VHX7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VI25-1", "uniprot_id": [ { "id": "NCDN_DROME", "url": "https://www.uniprot.org/uniprot/Q9VI25", "type": "external" } ], "mass": 81629.0, "length": 723, "protein_name": "Neurochondrin homolog", "gene_name": "Neurochondrin", "organism": "Fruit fly", "refseq_name": "neurochondrin", "refseq_ac": [ { "id": "NP_649658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649658", "type": "external" } ], "gene_names_uniprotkb": "Neurochondrin; CG2330", "gene_names_refseq": "CG2330; Dmel\\CG2330; NCDN; Neurochondrin", "protein_names_uniprotkb": "Neurochondrin homolog; dNeurochondrin", "protein_names_refseq": "CG2330-PA; Neurochondrin-PA; dNeurochondrin; neurochondrin", "tax_id": 7227, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dme:Dmel_CG2330)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;16415344", "class_list": "", "function": "Strongly up-regulated in Mhc mutants suggesting a role in muscle function., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8MSV0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0031175 neuron projection development;GO:0048168 regulation of neuronal synaptic plasticity;GO:0003012 muscle system process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VI25-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VI27-1", "uniprot_id": [ { "id": "Q9VI27_DROME", "url": "https://www.uniprot.org/uniprot/Q9VI27", "type": "external" } ], "mass": 38240.0, "length": 342, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG15185", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_649660", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649660", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG15185; CG15185; Dmel_CG15185", "gene_names_refseq": "CG15185; Dmel\\CG15185", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG15185-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15185)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VI27-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VIF1-1", "uniprot_id": [ { "id": "MUT7_DROME", "url": "https://www.uniprot.org/uniprot/Q9VIF1", "type": "external" } ], "mass": 71953.0, "length": 625, "protein_name": "Exonuclease mut-7 homolog", "gene_name": "Nbr", "organism": "Fruit fly", "refseq_name": "nibbler", "refseq_ac": [ { "id": "NP_610094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610094", "type": "external" } ], "gene_names_uniprotkb": "Nbr; CG9247", "gene_names_refseq": "CG9247; Dmel\\CG9247; Nbr; nbr", "protein_names_uniprotkb": "Exonuclease mut-7 homolog; 3.1.-.-; Exonuclease 3'-5' domain-containing protein 3 homolog; Protein nibbler", "protein_names_refseq": "CG9247-PA; Nbr-PA; nibbler", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9247)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;18327897;22055292;22055293", "class_list": "", "function": "Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs, in particular multiple-isoform miRNAs, which represents a critical step in miRNA maturation., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MSZ9", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003676 nucleic acid binding;GO:0008408 3'-5' exonuclease activity;GO:0000175 3'-5'-RNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1990904 ribonucleoprotein complex;GO:0043186 P granule", "go_biological_process": "GO:0035196 miRNA processing;GO:0034587 piRNA processing;GO:0010526 transposable element silencing;GO:0044747 pre-miRNA 3'-end processing;GO:0140990 primary piRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VIF1-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VIP0-1", "uniprot_id": [ { "id": "NESD_DROME", "url": "https://www.uniprot.org/uniprot/Q9VIP0", "type": "external" } ], "mass": 67728.0, "length": 602, "protein_name": "Protein nessun dorma", "gene_name": "nesd", "organism": "Fruit fly", "refseq_name": "nessun dorma, isoform A", "refseq_ac": [ { "id": "NP_610025", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610025", "type": "external" } ], "gene_names_uniprotkb": "nesd; CG10722", "gene_names_refseq": "38B.16; CG10722; Dmel\\CG10722; nesd", "protein_names_uniprotkb": "Protein nessun dorma", "protein_names_refseq": "CG10722-PA; nesd-PA; nessun dorma, isoform A; nessun dorma", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10722)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;21187330", "class_list": "", "function": "Required during male meiosis for completion of spermatocyte cytokinesis and possibly also required in female germline cells. Also involved in ring canal formation in male and female germline cells. Not essential for cleavage furrow ingression but is required for contractile ring stability and the attachment of the furrowing membrane to the actomyosin ring in late telophase. Displays high binding affinity for beta-galactosides., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NP13", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0045171 intercellular bridge;GO:0030496 midbody;GO:0097149 centralspindlin complex;GO:0035323 male germline ring canal;GO:0035324 female germline ring canal", "go_biological_process": "GO:0007283 spermatogenesis;GO:0007112 male meiosis cytokinesis;GO:0008335 female germline ring canal stabilization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VIP0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VIP1-1", "uniprot_id": [ { "id": "Q9VIP1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VIP1", "type": "external" } ], "mass": 15746.0, "length": 136, "protein_name": "Transcription initiation factor TFIID subunit 13", "gene_name": "Taf13", "organism": "Fruit fly", "refseq_name": "TBP-associated factor 13", "refseq_ac": [ { "id": "NP_610024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610024", "type": "external" } ], "gene_names_uniprotkb": "Taf13; 38B.15; CG10756; Dmel\\CG10756; Dmel_CG10756; TAF13; TAF18; TAF[[II]]18; TAF[[II]]; TAF; TFIID; Taf18; dTAF[[II]]18; taf13", "gene_names_refseq": "38B.15; CG10756; Dmel\\CG10756; TAF13; TAF18; TAF[[II]]18; TAF[[II]]; TAF; TFIID; Taf13; Taf18; dTAF[[II]]18; taf13", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 13; Transcription initiation factor TFIID 18 kDa subunit", "protein_names_refseq": "CG10756-PA; TBP-associated factor 13; TBP-associated factor 18kD; TBP-associated factor; Taf13-PA", "tax_id": 7227, "disease": "autosomal recessive intellectual developmental disorder 60 (Disease Ontology:DOID:0081222)", "pathway": " (dme:Dmel_CG10756); (R-DME-674695); (R-DME-6804756); (R-DME-6807505); (R-DME-73776); (R-DME-73779); (R-DME-75953); (R-DME-76042)", "pathway_count": 8, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF13, together with TAF11 and TBP, play key roles during promoter binding by the TFIID and TFIIA transcription factor complexes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VIP1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VIP8-1", "uniprot_id": [ { "id": "VLS_DROME", "url": "https://www.uniprot.org/uniprot/Q9VIP8", "type": "external" } ], "mass": 40608.0, "length": 367, "protein_name": "Protein valois", "gene_name": "vls", "organism": "Fruit fly", "refseq_name": "valois", "refseq_ac": [ { "id": "NP_610019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610019", "type": "external" } ], "gene_names_uniprotkb": "vls; CG10728; vsl", "gene_names_refseq": "38B.5; CG107278; CG10728; Dmel\\CG10728; Vls; dWD45; val; vls", "protein_names_uniprotkb": "Protein valois; MEP50 homolog", "protein_names_refseq": "CG10728-PA; valois; vls-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10728); (R-DME-3214858); (R-DME-9037629)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;15634703;15800004", "class_list": "", "function": "Involved in specific localization of cytoplasmic proteins during the formation of pole plasm. Required for synthesis and/or stability of oskar protein (osk) and localization of tudor (tud) in both the nuage and posterior pole of the oocyte. Required for normal posterior localization of osk in later stages of oogenesis and for posterior localization of the vasa (vas) protein during the entire process of pole plasm assembly. May act by regulating the complex that contains the arginine N-methyltransferase csul., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95SA0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0043186 P granule;GO:0045495 pole plasm", "go_biological_process": "GO:0009880 embryonic pattern specification;GO:0007315 pole plasm assembly;GO:0007349 cellularization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VIP8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VIR2-1", "uniprot_id": [ { "id": "TOTF_DROME", "url": "https://www.uniprot.org/uniprot/Q9VIR2", "type": "external" } ], "mass": 13975.0, "length": 125, "protein_name": "Protein Turandot F", "gene_name": "TotF", "organism": "Fruit fly", "refseq_name": "turandot F", "refseq_ac": [ { "id": "NP_536780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_536780", "type": "external" } ], "gene_names_uniprotkb": "TotF; CG31691", "gene_names_refseq": "CG13963; CG31691; Dmel\\CG31691; Tot F; TotF; tot", "protein_names_uniprotkb": "Protein Turandot F", "protein_names_refseq": "CG31691-PA; TotF-PA; turandot F", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31691)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;11409894;12537572", "class_list": "", "function": "A humoral factor that may play a role in stress tolerance., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q962D8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0045087 innate immune response;GO:0034605 cellular response to heat;GO:0009617 response to bacterium;GO:0009615 response to virus;GO:0009411 response to UV", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VIR2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VIU7-1", "uniprot_id": [ { "id": "DPM1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VIU7", "type": "external" } ], "mass": 27002.0, "length": 241, "protein_name": "Dolichol-phosphate mannosyltransferase subunit 1", "gene_name": "Dpm1", "organism": "Fruit fly", "refseq_name": "Dolichyl-phosphate mannosyltransferase subunit 1", "refseq_ac": [ { "id": "NP_609980", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609980", "type": "external" } ], "gene_names_uniprotkb": "Dpm1; CG10166", "gene_names_refseq": "CG10166; DPM1; Dmel\\CG10166; Dol-P-ManTase; Dpm1; dDPM", "protein_names_uniprotkb": "Dolichol-phosphate mannosyltransferase subunit 1; 2.4.1.83; DPM synthase; Dolichol-phosphate mannose synthase; Dolichyl-phosphate beta-D-mannosyltransferase; MPD synthase; Mannose-P-dolichol synthase", "protein_names_refseq": "CG10166-PA; Dolichol-phosphate mannosyltransferase; Dolichyl-phosphate mannosyltransferase subunit 1; Dpm1-PA", "tax_id": 7227, "disease": "congenital disorder of glycosylation type I (Disease Ontology:DOID:0050570); congenital disorder of glycosylation Ie (Disease Ontology:DOID:0080557)", "pathway": " (dme:Dmel_CG10166); (R-DME-162699)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "glycogene;glycosyltransferase", "function": "Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.83", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.83", "type": "external" } ], "go_molecular_function": "GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0033185 dolichol-phosphate-mannose synthase complex;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0035269 protein O-linked glycosylation via mannose;GO:0006506 GPI anchor biosynthetic process;GO:0180047 dolichol phosphate mannose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VIU7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VJ26-1", "uniprot_id": [ { "id": "EFHD2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VJ26", "type": "external" } ], "mass": 25087.0, "length": 217, "protein_name": "EF-hand domain-containing protein D2 homolog", "gene_name": "Swip-1", "organism": "Fruit fly", "refseq_name": "Swiprosin-1, isoform B", "refseq_ac": [ { "id": "NP_001286079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286079", "type": "external" } ], "gene_names_uniprotkb": "Swip-1; CG10641; DSwip-1; Dmel\\CG10641; Dmel_CG10641; EFhd2; efhd2; efhd; swip1; swip", "gene_names_refseq": "CG10641; DSwip-1; Dmel\\CG10641; EFhd2; Swip-1; efhd2; efhd; swip1; swip", "protein_names_uniprotkb": "EF-hand domain-containing protein D2 homolog; Swiprosin-1 homolog", "protein_names_refseq": "CG10641-PB; EF-hand domain containing 2; Swip-1-PB; Swiprosin-1, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10641)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0005509 calcium ion binding;GO:0061891 calcium ion sensor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0030667 secretory granule membrane", "go_biological_process": "GO:0045055 regulated exocytosis;GO:0051764 actin crosslink formation;GO:0042060 wound healing;GO:0007498 mesoderm development;GO:0007594 puparial adhesion", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VJ26-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VJ29-1", "uniprot_id": [ { "id": "TNG6_DROME", "url": "https://www.uniprot.org/uniprot/Q9VJ29", "type": "external" } ], "mass": 105204.0, "length": 921, "protein_name": "Transport and Golgi organization protein 6", "gene_name": "Tango6", "organism": "Fruit fly", "refseq_name": "transport and golgi organization 6", "refseq_ac": [ { "id": "NP_609922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609922", "type": "external" } ], "gene_names_uniprotkb": "Tango6; CG18398", "gene_names_refseq": "CG18398; Dmel\\CG18398; TANGO6; Tango6; Tango", "protein_names_uniprotkb": "Transport and Golgi organization protein 6", "protein_names_refseq": "CG18398-PA; Tango6-PA; transport and golgi organization 6", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG18398)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;16452979", "class_list": "", "function": "May be involved in protein secretion and Golgi organization., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0009306 protein secretion;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VJ29-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VJ33-1", "uniprot_id": [ { "id": "NEDD8_DROME", "url": "https://www.uniprot.org/uniprot/Q9VJ33", "type": "external" } ], "mass": 9346.0, "length": 84, "protein_name": "Ubiquitin-like protein NEDD8", "gene_name": "Nedd8", "organism": "Fruit fly", "refseq_name": "Nedd8 ubiquitin like modifier, isoform B", "refseq_ac": [ { "id": "NP_001286070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286070", "type": "external" } ], "gene_names_uniprotkb": "Nedd8; CG10679; Dmel\\CG10679; Dmel_CG10679; NEDD8; Nedd; dNEDD8; nedd8", "gene_names_refseq": "CG10679; Dmel\\CG10679; NEDD8; Nedd8; Nedd; dNEDD8; nedd8", "protein_names_uniprotkb": "Ubiquitin-like protein NEDD8; Neddylin", "protein_names_refseq": "CG10679-PB; Nedd8 ubiquitin like modifier, isoform B; Nedd8-PB; neural precursor cell-expressed developmentally downregulated", "tax_id": 7227, "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); Parkinson's disease (Disease Ontology:DOID:14330); malignant astrocytoma (Disease Ontology:DOID:3069)", "pathway": " (dme:Dmel_CG10679); (R-DME-2173789); (R-DME-5689603); (R-DME-8856825); (R-DME-8951664); (R-DME-917937)", "pathway_count": 6, "publication_count": 14, "publication_id_list": "10731132;12231629;12537568;12537572;12537573;12537574;15843622;16110336;16127432;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Ubiquitin-like protein which plays an important role in cell cycle control, embryogenesis and neurogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex Uba3-Ula1 and linkage to the E2 enzyme UbcE2M. Attachment of Nedd8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29QE5", "ec_number_list": [], "go_molecular_function": "GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0008283 cell population proliferation;GO:0030162 regulation of proteolysis;GO:0031647 regulation of protein stability;GO:0030431 sleep;GO:0008589 regulation of smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VJ33-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VJ97-1", "uniprot_id": [ { "id": "JMJD4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VJ97", "type": "external" } ], "mass": 49169.0, "length": 425, "protein_name": "2-oxoglutarate and iron-dependent oxygenase JMJD4 homolog", "gene_name": "JMJD4", "organism": "Fruit fly", "refseq_name": "jumonji domain containing 4, isoform B", "refseq_ac": [ { "id": "NP_001286031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286031", "type": "external" } ], "gene_names_uniprotkb": "JMJD4; CG7200; Dmel\\CG7200; Dmel_CG7200", "gene_names_refseq": "CG7200; Dmel\\CG7200; JMJD4", "protein_names_uniprotkb": "2-oxoglutarate and iron-dependent oxygenase JMJD4 homolog; 1.14.11.-; JmjC domain-containing protein 4 homolog; Jumonji domain-containing protein 4; Lysyl-hydroxylase JMJD4 homolog", "protein_names_refseq": "CG7200-PB; JMJD4-PB; jumonji domain containing 4, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7200); (R-DME-9629569)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;28701701;29339751", "class_list": "", "function": "Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of eRF1 thereby promoting the translational termination efficiency of eRF1 (By similarity). May be involved in regulation of chromatin structure, promoting expansion of heterochromatin (PubMed:28701701)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0043565 sequence-specific DNA binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity;GO:0106156 peptidyl-lysine 4-dioxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0045905 positive regulation of translational termination;GO:0018126 protein hydroxylation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VJ97-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VJF2-1", "uniprot_id": [ { "id": "GR36B_DROME", "url": "https://www.uniprot.org/uniprot/Q9VJF2", "type": "external" } ], "mass": 44890.0, "length": 391, "protein_name": "Putative gustatory receptor 36b", "gene_name": "Gr36b", "organism": "Fruit fly", "refseq_name": "gustatory receptor 36b", "refseq_ac": [ { "id": "NP_724039", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_724039", "type": "external" } ], "gene_names_uniprotkb": "Gr36b; CG31744", "gene_names_refseq": "CG15137; CG31744; Dmel\\CG31744; GR36b; Gr36B.2; Gr36B2; Gr36b", "protein_names_uniprotkb": "Putative gustatory receptor 36b", "protein_names_refseq": "CG31744-PA; Gr36b-PA; gustatory receptor 36B2; gustatory receptor 36b", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG31744)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;11516643;12537572;22031876", "class_list": "", "function": "Probable gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0008527 taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007165 signal transduction;GO:0034220 monoatomic ion transmembrane transport;GO:0050909 sensory perception of taste", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VJF2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VJN2-1", "uniprot_id": [ { "id": "Q9VJN2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VJN2", "type": "external" } ], "mass": 81898.0, "length": 710, "protein_name": "Aminopeptidase", "gene_name": "BG:DS00365.1", "organism": "Fruit fly", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "BG:DS00365.1; CG7653; Dmel\\CG7653; Dmel_CG7653", "gene_names_refseq": "", "protein_names_uniprotkb": "Aminopeptidase", "protein_names_refseq": "", "tax_id": 7227, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VJN2-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VJQ5-1", "uniprot_id": [ { "id": "NC2B_DROME", "url": "https://www.uniprot.org/uniprot/Q9VJQ5", "type": "external" } ], "mass": 20914.0, "length": 183, "protein_name": "Protein Dr1", "gene_name": "NC2beta", "organism": "Fruit fly", "refseq_name": "negative cofactor 2beta", "refseq_ac": [ { "id": "NP_609736", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609736", "type": "external" } ], "gene_names_uniprotkb": "NC2beta; CG4185; Dr1", "gene_names_refseq": "BG:DS00929.3; CG4185; Dmel\\CG4185; Dr1; NC2 beta; NC2beta; Nc2b; dDr1; dNC2beta; dNC2", "protein_names_uniprotkb": "Protein Dr1; Down-regulator of transcription 1; NC2-beta; Negative cofactor 2-beta; dNC2", "protein_names_refseq": "CG4185-PA; NC2beta-PA; negative cofactor 2beta", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4185)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10471707;10731132;11062130;12537569;12537572;16120803;18327268", "class_list": "", "function": "Bifunctional basic transcription factor. Activates transcription of DPE (Downstream Promoter Element) containing promoters while repressing transcription of promoters which contain TATA elements (PubMed:11062130). Together with Chrac-14, promotes nucleosome sliding of ATP-dependent nucleosome remodeling complexes (PubMed:18327268)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2XYD4;Q9NKA2", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0017025 TBP-class protein binding;GO:0001046 core promoter sequence-specific DNA binding;GO:0016251 RNA polymerase II general transcription initiation factor activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0017054 negative cofactor 2 complex;GO:0140672 ATAC complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9VJQ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VJZ5-1", "uniprot_id": [ { "id": "Q9VJZ5_DROME", "url": "https://www.uniprot.org/uniprot/Q9VJZ5", "type": "external" } ], "mass": 43319.0, "length": 380, "protein_name": "Two A-associated protein of 42kDa", "gene_name": "Tap42", "organism": "Fruit fly", "refseq_name": "Two A-associated protein of 42kDa", "refseq_ac": [ { "id": "NP_723811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_723811", "type": "external" } ], "gene_names_uniprotkb": "Tap42; CG31852; CG6537; Dmel\\CG31852; Dmel_CG31852; dTap42", "gene_names_refseq": "CG31852; CG6537; Dmel\\CG31852; Tap-42/CG31852; Tap42; dTap42", "protein_names_uniprotkb": "Two A-associated protein of 42kDa", "protein_names_refseq": "CG31852-PA; Tap42-PA; Two A-associated protein of 42kDa", "tax_id": 7227, "disease": "corpus callosum agenesis-intellectual disability-coloboma-micrognathia syndrome (Disease Ontology:DOID:0060816)", "pathway": " (dme:Dmel_CG31852)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity;GO:0051721 protein phosphatase 2A binding;GO:0004864 protein phosphatase inhibitor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0000159 protein phosphatase type 2A complex", "go_biological_process": "GO:0035303 regulation of dephosphorylation;GO:0009966 regulation of signal transduction;GO:0007052 mitotic spindle organization;GO:0007472 wing disc morphogenesis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VJZ5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VK13-1", "uniprot_id": [ { "id": "MABI_DROME", "url": "https://www.uniprot.org/uniprot/Q9VK13", "type": "external" } ], "mass": 24047.0, "length": 206, "protein_name": "Protein Mabiki", "gene_name": "Mabi", "organism": "Fruit fly", "refseq_name": "mabiki", "refseq_ac": [ { "id": "NP_609624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609624", "type": "external" } ], "gene_names_uniprotkb": "Mabi; CG15479", "gene_names_refseq": "CG15479; DM2; Dmel\\CG15479; Mabi", "protein_names_uniprotkb": "Protein Mabiki", "protein_names_refseq": "CG15479-PA; Mabi-PA; mabiki", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15479); (R-DME-2559582); (R-DME-9616222)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10731132;12537572;24671768", "class_list": "", "function": "Plays a role in inducing apoptosis and is involved in the repair of head patterning defects in the embryo caused by extra maternal copies of the homeotic gene bicoid., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VK13-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VK89-1", "uniprot_id": [ { "id": "TRM1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VK89", "type": "external" } ], "mass": 64957.0, "length": 578, "protein_name": "tRNA (guanine(26)-N(2))-dimethyltransferase", "gene_name": "Trm1", "organism": "Fruit fly", "refseq_name": "tRNA methyltransferase 1", "refseq_ac": [ { "id": "NP_609566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609566", "type": "external" } ], "gene_names_uniprotkb": "Trm1; CG6388", "gene_names_refseq": "CG6388; Dmel\\CG6388; TRM1; Trm1", "protein_names_uniprotkb": "tRNA (guanine(26)-N(2))-dimethyltransferase; 2.1.1.216; tRNA 2,2-dimethylguanosine-26 methyltransferase; tRNA(guanine-26,N(2)-N(2)) methyltransferase; tRNA(m(2,2)G26)dimethyltransferase", "protein_names_refseq": "CG6388-PA; Trm1-PA; tRNA methyltransferase 1", "tax_id": 7227, "disease": "autosomal recessive intellectual developmental disorder 68 (Disease Ontology:DOID:0081229)", "pathway": " (dme:Dmel_CG6388)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;33253256", "class_list": "", "function": "Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.216", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.216", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000049 tRNA binding;GO:0160104 tRNA (guanine(26)-N2)-dimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion", "go_biological_process": "GO:0002940 tRNA N2-guanine methylation;GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VK89-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VKD3-1", "uniprot_id": [ { "id": "NFS1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VKD3", "type": "external" } ], "mass": 51074.0, "length": 462, "protein_name": "Cysteine desulfurase, mitochondrial", "gene_name": "Nfs1", "organism": "Fruit fly", "refseq_name": "Nfs1 cysteine desulfurase", "refseq_ac": [ { "id": "NP_609533", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609533", "type": "external" } ], "gene_names_uniprotkb": "Nfs1; CG12264", "gene_names_refseq": "CG12264-PA; CG12264; CSE; DmNfs1; Dmel\\CG12264; NFS1; Nfs1", "protein_names_uniprotkb": "Cysteine desulfurase, mitochondrial; 2.8.1.7", "protein_names_refseq": "CG12264-PA; IscS homologue; Nfs1 cysteine desulfurase; Nfs1-PA", "tax_id": 7227, "disease": "combined oxidative phosphorylation deficiency 52 (Disease Ontology:DOID:0070425)", "pathway": " (dme:Dmel_CG12264); (R-DME-1362409); (R-DME-947581); (R-DME-9865881)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;20534482;29491838", "class_list": "", "function": "Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VKD4", "ec_number_list": [ { "id": "2.8.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.7", "type": "external" }, { "id": "7.1.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.8", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0046872 metal ion binding;GO:0051536 iron-sulfur cluster binding;GO:0031071 cysteine desulfurase activity;GO:0097163 sulfur carrier activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0099128 mitochondrial [2Fe-2S] assembly complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0044571 [2Fe-2S] cluster assembly;GO:0070903 mitochondrial tRNA thio-modification;GO:0006777 Mo-molybdopterin cofactor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VKD3-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VKI3-1", "uniprot_id": [ { "id": "VTU4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VKI3", "type": "external" } ], "mass": 12100.0, "length": 116, "protein_name": "Vitelline membrane protein Vm32E", "gene_name": "Vm32E", "organism": "Fruit fly", "refseq_name": "vitelline membrane 32E, isoform B", "refseq_ac": [ { "id": "NP_001285837", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285837", "type": "external" } ], "gene_names_uniprotkb": "Vm32E; CG16874", "gene_names_refseq": "CG16874; Dmel\\CG16874; VM321; VM32E; VMP32E; Vm32Ea; Vm32Ec; Vm32E; Vm3", "protein_names_uniprotkb": "Vitelline membrane protein Vm32E", "protein_names_refseq": "CG16874-PB; Vm32E-PB; vitelline membrane 32E, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG16874)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;17244601;19540119;2495206", "class_list": "", "function": "Major early eggshell protein., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4UM13;Q24588;Q29QF0;Q629J1;X2J9F7", "ec_number_list": [], "go_molecular_function": "GO:0008316 structural constituent of vitelline membrane", "go_cellular_component": "GO:0005615 extracellular space;GO:0042600 egg chorion;GO:0060388 vitelline envelope", "go_biological_process": "GO:0007305 vitelline membrane formation involved in chorion-containing eggshell formation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VKI3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VKJ0-1", "uniprot_id": [ { "id": "HGD_DROME", "url": "https://www.uniprot.org/uniprot/Q9VKJ0", "type": "external" } ], "mass": 49398.0, "length": 439, "protein_name": "Homogentisate 1,2-dioxygenase", "gene_name": "Hgd", "organism": "Fruit fly", "refseq_name": "homogentisate 1,2-dioxygenase", "refseq_ac": [ { "id": "NP_523544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523544", "type": "external" } ], "gene_names_uniprotkb": "Hgd; CG4779; Hgo", "gene_names_refseq": "CG4779; Dmel\\CG4779; HGO; Hgo; hgo", "protein_names_uniprotkb": "Homogentisate 1,2-dioxygenase; 1.13.11.5; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase", "protein_names_refseq": "CG4779-PA; hgo-PA; homogentisate 1,2-dioxygenase", "tax_id": 7227, "disease": "alkaptonuria (Disease Ontology:DOID:9270)", "pathway": " (dme:Dmel_CG4779); (R-DME-8963684)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86P40", "ec_number_list": [ { "id": "1.13.11.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.5", "type": "external" } ], "go_molecular_function": "GO:0004411 homogentisate 1,2-dioxygenase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006559 L-phenylalanine catabolic process;GO:0006572 L-tyrosine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VKJ0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VKJ1-1", "uniprot_id": [ { "id": "MPND_DROME", "url": "https://www.uniprot.org/uniprot/Q9VKJ1", "type": "external" } ], "mass": 149953.0, "length": 1412, "protein_name": "MPN domain-containing protein CG4751", "gene_name": "CG4751", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_609495", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609495", "type": "external" } ], "gene_names_uniprotkb": "CG4751", "gene_names_refseq": "CG4751; Dmel\\CG4751; Q9VKJ1", "protein_names_uniprotkb": "MPN domain-containing protein CG4751; 3.4.-.-", "protein_names_refseq": "CG4751-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4751)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18327897", "class_list": "", "function": "Probable protease., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0140492 metal-dependent deubiquitinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VKJ1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VKJ7-1", "uniprot_id": [ { "id": "GR32A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VKJ7", "type": "external" } ], "mass": 52925.0, "length": 461, "protein_name": "Gustatory and pheromone receptor 32a", "gene_name": "Gr32a", "organism": "Fruit fly", "refseq_name": "gustatory receptor 32a", "refseq_ac": [ { "id": "NP_523543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523543", "type": "external" } ], "gene_names_uniprotkb": "Gr32a; CG14916; GR32D.1", "gene_names_refseq": "32D.1; 32D1; CG14916; Dmel\\CG14916; GR32D.1; GR32D1; GR32a; Gr32A; Gr32D1; Gr32a; Gr32d", "protein_names_uniprotkb": "Gustatory and pheromone receptor 32a", "protein_names_refseq": "CG14916-PA; Gr32a-PA; gustatory receptor 32D.1; gustatory receptor 32a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14916)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10710312;10731132;11516643;12537572;18641642;20036540;20797533;21516101;22031876;23106154;23810192", "class_list": "", "function": "Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates. Required for the response to N,N-Diethyl-meta-toluamide (DEET), the most widely used insect repellent worldwide. Functions as a pheromone receptor for a male inhibitory pheromone and promotes male-male aggression and suppresses male-male courtship. Also promotes preferentially virgin females courting over mated females., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0008527 taste receptor activity;GO:0170021 ionotropic taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0008049 male courtship behavior;GO:0007165 signal transduction;GO:0034220 monoatomic ion transmembrane transport;GO:0009636 response to toxic substance;GO:0007635 chemosensory behavior", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VKJ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VKU7-1", "uniprot_id": [ { "id": "GCP4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VKU7", "type": "external" } ], "mass": 74980.0, "length": 650, "protein_name": "Gamma-tubulin complex component 4 homolog", "gene_name": "Grip75", "organism": "Fruit fly", "refseq_name": "Grip75", "refseq_ac": [ { "id": "NP_609412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609412", "type": "external" } ], "gene_names_uniprotkb": "Grip75; 75p; CG6176", "gene_names_refseq": "75p; CG6176; DGrip75; Dgrip75/d75p; Dgrip75s; Dgrip75; Dmel\\CG6176; Grip75; d75p; dGrip75; grip75", "protein_names_uniprotkb": "Gamma-tubulin complex component 4 homolog; Gamma-ring complex protein 75 kDa; d75p; dGrip75", "protein_names_refseq": "CG6176-PA; DGrip75; Grip75-PA; Grip75", "tax_id": 7227, "disease": "microcephaly and chorioretinopathy 3 (Disease Ontology:DOID:0080107)", "pathway": " (dme:Dmel_CG6176)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10562286;10731132;12537572;18327897", "class_list": "", "function": "Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9U1J7", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005874 microtubule;GO:0000930 gamma-tubulin complex;GO:0000931 gamma-tubulin ring complex", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0007020 microtubule nucleation;GO:0051225 spindle assembly;GO:0051321 meiotic cell cycle;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VKU7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VL00-1", "uniprot_id": [ { "id": "OTUBL_DROME", "url": "https://www.uniprot.org/uniprot/Q9VL00", "type": "external" } ], "mass": 30372.0, "length": 262, "protein_name": "Ubiquitin thioesterase otubain-like", "gene_name": "CG4968", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_609375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609375", "type": "external" } ], "gene_names_uniprotkb": "CG4968", "gene_names_refseq": "CG4968; Dmel\\CG4968; OTUB1; Q9VL00", "protein_names_uniprotkb": "Ubiquitin thioesterase otubain-like; 3.4.19.12; Deubiquitinating enzyme otubain-like; Ubiquitin-specific-processing protease otubain-like", "protein_names_refseq": "CG4968-PA; uncharacterized protein", "tax_id": 7227, "disease": "lupus nephritis (Disease Ontology:DOID:0080162); IgA glomerulonephritis (Disease Ontology:DOID:2986)", "pathway": " (dme:Dmel_CG4968); (R-DME-5689880); (R-DME-5689896)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Possible hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0043130 ubiquitin binding;GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0061059 positive regulation of peptidoglycan recognition protein signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VL00-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VL06-1", "uniprot_id": [ { "id": "UFD4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VL06", "type": "external" } ], "mass": 302150.0, "length": 2727, "protein_name": "E3 ubiquitin-protein ligase Ufd4", "gene_name": "Ufd4", "organism": "Fruit fly", "refseq_name": "ubiquitin fusion-degradation 4-like", "refseq_ac": [ { "id": "NP_609369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609369", "type": "external" } ], "gene_names_uniprotkb": "Ufd4; CG5604", "gene_names_refseq": "CG5604; Dmel\\CG5604; Ufd4; ufd4", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Ufd4; 2.3.2.26; Ubiquitin fusion-degradation 4-like", "protein_names_refseq": "CG5604-PA; Ufd4-PA; ubiquitin fusion-degradation 4-like", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5604)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;27552662", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the E2 enzyme Unc6 and the putative E3 ligases poe and Kcmf1 to mediate the ubiquitination and proteasomal degradation of rl/MAPK (PubMed:27552662)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6NR00", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0000209 protein polyubiquitination;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VL06-1", "record_type": "protein", "filter_code": "0000000.0000101.001000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VL13-1", "uniprot_id": [ { "id": "MOB3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VL13", "type": "external" } ], "mass": 25546.0, "length": 220, "protein_name": "MOB kinase activator-like 3", "gene_name": "Mob3", "organism": "Fruit fly", "refseq_name": "MOB kinase activator 3", "refseq_ac": [ { "id": "NP_609364", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609364", "type": "external" } ], "gene_names_uniprotkb": "Mob3; CG4946", "gene_names_refseq": "CG4946; DMob3; Dmel\\CG4946; Dmob3; Mob3; dmob3", "protein_names_uniprotkb": "MOB kinase activator-like 3; Dmob3; Mob as tumor suppressor protein 3; Mps one binder kinase activator-like 3", "protein_names_refseq": "CG4946-PA; MOB kinase activator 3; Mob3-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4946)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;15975907", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VL13-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VL59-1", "uniprot_id": [ { "id": "ZGPAT_DROME", "url": "https://www.uniprot.org/uniprot/Q9VL59", "type": "external" } ], "mass": 58634.0, "length": 513, "protein_name": "Zinc finger CCCH-type with G patch domain-containing protein", "gene_name": "Dmel\\CG4709", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001285788", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285788", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG4709; CG4709; Dmel_CG4709; ZGPAT", "gene_names_refseq": "CG4709; Dmel\\CG4709; ZGPAT", "protein_names_uniprotkb": "Zinc finger CCCH-type with G patch domain-containing protein", "protein_names_refseq": "CG4709-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4709)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Transcription repressor., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VL59-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VL73-1", "uniprot_id": [ { "id": "Q9VL73_DROME", "url": "https://www.uniprot.org/uniprot/Q9VL73", "type": "external" } ], "mass": 55866.0, "length": 510, "protein_name": "MIF4G domain-containing protein", "gene_name": "Dmel\\CG13124", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform E", "refseq_ac": [ { "id": "NP_001162923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162923", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG13124; CG13124; Dmel_CG13124", "gene_names_refseq": "CG13124; Dmel\\CG13124", "protein_names_uniprotkb": "MIF4G domain-containing protein", "protein_names_refseq": "CG13124-PE; uncharacterized protein, isoform E", "tax_id": 7227, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008494 translation activator activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006446 regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VL73-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VL84-1", "uniprot_id": [ { "id": "PPK11_DROME", "url": "https://www.uniprot.org/uniprot/Q9VL84", "type": "external" } ], "mass": 59999.0, "length": 516, "protein_name": "Pickpocket protein 11", "gene_name": "ppk11", "organism": "Fruit fly", "refseq_name": "pickpocket 11", "refseq_ac": [ { "id": "NP_001334672", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334672", "type": "external" } ], "gene_names_uniprotkb": "ppk11; CG34058; CG4110", "gene_names_refseq": "CG34058; CG4110; Dmel\\CG34058; ENaC; PPK11; Ppk11; ppk11", "protein_names_uniprotkb": "Pickpocket protein 11; PPK11", "protein_names_refseq": "CG34058-PA; pickpocket 11; pickpocket11; ppk11-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG34058)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;12571352;12848938", "class_list": "", "function": "Part of a complex that plays a role in tracheal liquid clearance. In both larvae and adults, contributes to the behavioral response to salt. Probable role in sodium transport., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q86LH0", "ec_number_list": [], "go_molecular_function": "GO:0005272 sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0009651 response to salt stress;GO:0035725 sodium ion transmembrane transport;GO:0006814 sodium ion transport;GO:0060025 regulation of synaptic activity;GO:0035002 liquid clearance, open tracheal system", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VL84-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VL96-1", "uniprot_id": [ { "id": "PESC_DROME", "url": "https://www.uniprot.org/uniprot/Q9VL96", "type": "external" } ], "mass": 73863.0, "length": 627, "protein_name": "Pescadillo homolog", "gene_name": "CG4364", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_609305", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609305", "type": "external" } ], "gene_names_uniprotkb": "CG4364", "gene_names_refseq": "CG4364; Dmel\\CG4364", "protein_names_uniprotkb": "Pescadillo homolog", "protein_names_refseq": "CG4364-PA; uncharacterized protein", "tax_id": 7227, "disease": "Shwachman-Diamond syndrome (Disease Ontology:DOID:0060479)", "pathway": " (dme:Dmel_CG4364); (R-DME-6791226)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18327897", "class_list": "", "function": "Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0070545 PeBoW complex", "go_biological_process": "GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VL96-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VLA2-1", "uniprot_id": [ { "id": "GCM2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VLA2", "type": "external" } ], "mass": 65674.0, "length": 606, "protein_name": "Transcription factor glial cells missing 2", "gene_name": "gcm2", "organism": "Fruit fly", "refseq_name": "gcm2", "refseq_ac": [ { "id": "NP_609302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609302", "type": "external" } ], "gene_names_uniprotkb": "gcm2; CG3858", "gene_names_refseq": "CG3858; Dmel\\CG3858; FBgn0019809; GCM-2; Gcm2; dGCM2; gcm2", "protein_names_uniprotkb": "Transcription factor glial cells missing 2; Protein glide-2", "protein_names_refseq": "CG3858-PA; gcm2-PA; gcm2; glial cells missing 2; glide glide2; glide2", "tax_id": 7227, "disease": "familial isolated hypoparathyroidism 2 (Disease Ontology:DOID:0061151); hyperparathyroidism (Disease Ontology:DOID:13543)", "pathway": " (dme:Dmel_CG3858)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;11532931;12167411;12537572", "class_list": "", "function": "Transcription factor with a minor role promoting glial cell differentiation and a more significant role in hematocyte differentiation. Gcm2, together with gcm, is required for the proliferation of plasmatocyte precursors, the expression of Croquemort protein, and the ability of plasmatocytes to convert into macrophages., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V704;Q8N012;Q8WST6;Q9NCQ2", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0021782 glial cell development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030182 neuron differentiation;GO:0048813 dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VLA2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VLB0-1", "uniprot_id": [ { "id": "Q9VLB0_DROME", "url": "https://www.uniprot.org/uniprot/Q9VLB0", "type": "external" } ], "mass": 23522.0, "length": 205, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG13113", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_609296", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609296", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG13113; CG13113; Dmel_CG13113", "gene_names_refseq": "CG13113; Dmel\\CG13113", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG13113-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13113)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0042600 egg chorion", "go_biological_process": "GO:0007306 egg chorion assembly", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VLB0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VLC0-1", "uniprot_id": [ { "id": "VPS54_DROME", "url": "https://www.uniprot.org/uniprot/Q9VLC0", "type": "external" } ], "mass": 105241.0, "length": 940, "protein_name": "Vacuolar protein sorting-associated protein 54", "gene_name": "scat", "organism": "Fruit fly", "refseq_name": "scattered", "refseq_ac": [ { "id": "NP_524905", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524905", "type": "external" } ], "gene_names_uniprotkb": "scat; CG3766", "gene_names_refseq": "CG3766; Dmel\\CG3766; Scat; Vps54; ms(2)05289; ms(2)30B; scat", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 54; Protein scattered", "protein_names_refseq": "CG3766-PA; scat-PA; scattered", "tax_id": 7227, "disease": "amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); Werdnig-Hoffmann disease (Disease Ontology:DOID:13137); motor neuron disease (Disease Ontology:DOID:231)", "pathway": " (dme:Dmel_CG3766); (R-DME-6811440)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;18327897;9550716", "class_list": "", "function": "May be involved in retrograde transport from early and late endosomes to late Golgi (By similarity). Required during spermatogenesis for sperm individualization., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding", "go_cellular_component": "GO:0000938 GARP complex;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0000138 Golgi trans cisterna", "go_biological_process": "GO:0015031 protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0001675 acrosome assembly;GO:0032456 endocytic recycling;GO:0007291 sperm individualization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VLC0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VLC1-1", "uniprot_id": [ { "id": "FUTB_DROME", "url": "https://www.uniprot.org/uniprot/Q9VLC1", "type": "external" } ], "mass": 51801.0, "length": 444, "protein_name": "Inactive alpha(1,3)-fucosyltransferase B", "gene_name": "FucTB", "organism": "Fruit fly", "refseq_name": "alpha1,3-fucosyltransferase B, isoform D", "refseq_ac": [ { "id": "NP_001285779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285779", "type": "external" } ], "gene_names_uniprotkb": "FucTB; CG4435; CT14430; Dmel\\CG4435; Dmel_CG4435", "gene_names_refseq": "CG4435; CT14430; Dmel\\CG4435; FucTB", "protein_names_uniprotkb": "Inactive alpha(1,3)-fucosyltransferase B", "protein_names_refseq": "CG4435-PD; FucTB-PD; alpha1,3-fucosyltransferase B, isoform D; alpha1,3-fucosyltransferase", "tax_id": 7227, "disease": "stomach cancer (Disease Ontology:DOID:10534)", "pathway": " (dme:Dmel_CG4435)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;11382750;12537568;12537572;12537573;12537574;16110336;16314421;17569856;17569867;25589440;26109356;26109357", "class_list": "glycogene;glycosyltransferase", "function": "Lacks glycoprotein 3-alpha-L-fucosyltransferase activity., [UniProtKB, PubMed, PubMed]; Protein O-fucosyltransferase that specifically catalyzes O-fucosylation of serine or threonine residues in EMI domains of target proteins. Attaches fucose through an O-glycosidic linkage. O-fucosylation of EMI domain-containing proteins may be required for facilitating protein folding and secretion., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q4QQB0;Q8I928", "ec_number_list": [], "go_molecular_function": "GO:0008417 fucosyltransferase activity;GO:0046920 alpha-(1->3)-fucosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VLC1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VLE5-1", "uniprot_id": [ { "id": "OR30A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VLE5", "type": "external" } ], "mass": 43868.0, "length": 377, "protein_name": "Odorant receptor 30a", "gene_name": "Or30a", "organism": "Fruit fly", "refseq_name": "odorant receptor 30a", "refseq_ac": [ { "id": "NP_523520", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523520", "type": "external" } ], "gene_names_uniprotkb": "Or30a; CG13106", "gene_names_refseq": "30A.1; 30a; CG13106; DOR56; Dmel\\CG13106; OR30a; Or30a", "protein_names_uniprotkb": "Odorant receptor 30a", "protein_names_refseq": "CG13106-PA; Or30a-PA; odorant receptor 30a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13106)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;21613503;21857978", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to propyl acetate and anisole., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VLE5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VLJ0-1", "uniprot_id": [ { "id": "PDE6D_DROME", "url": "https://www.uniprot.org/uniprot/Q9VLJ0", "type": "external" } ], "mass": 17404.0, "length": 151, "protein_name": "Probable cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PrBP", "organism": "Fruit fly", "refseq_name": "Prenyl-binding protein", "refseq_ac": [ { "id": "NP_609246", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609246", "type": "external" } ], "gene_names_uniprotkb": "PrBP; CG9296", "gene_names_refseq": "CG9296; DmPrBP/delta; DmPrBP; Dmel\\CG9296; PrBP", "protein_names_uniprotkb": "Probable cGMP 3',5'-cyclic phosphodiesterase subunit delta; DmPrBP", "protein_names_refseq": "CG9296-PA; PrBP-PA; Prenyl-binding protein", "tax_id": 7227, "disease": "Joubert syndrome 22 (Disease Ontology:DOID:0110991)", "pathway": " (dme:Dmel_CG9296); (R-DME-9648002)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18503409", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0050953 sensory perception of light stimulus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VLJ0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VLJ8-1", "uniprot_id": [ { "id": "MOCS3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VLJ8", "type": "external" } ], "mass": 50239.0, "length": 453, "protein_name": "Adenylyltransferase and sulfurtransferase MOCS3", "gene_name": "Mocs3", "organism": "Fruit fly", "refseq_name": "Ubiquitin-like activating enzyme 4, isoform B", "refseq_ac": [ { "id": "NP_001260255", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260255", "type": "external" } ], "gene_names_uniprotkb": "Mocs3; CG13090; Uba4", "gene_names_refseq": "CG13090; Dmel\\CG13090; Mocs3; Uba4; dMoaD", "protein_names_uniprotkb": "Adenylyltransferase and sulfurtransferase MOCS3; Adenylyltransferase MOCS3; Molybdenum cofactor synthesis protein 3; Sulfur carrier protein MOCS2A adenylyltransferase; Sulfur carrier protein MOCS2A sulfurtransferase; Sulfurtransferase MOCS3; Ubiquitin activating enzyme 4", "protein_names_refseq": "CG13090-PB; Uba4 homologue; Uba4 ortholog; Uba4-PB; Ubiquitin-like activating enzyme 4, isoform B; ubiquitin activating enzyme 4", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13090); (R-DME-947581)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;18327897;26715182;29491838", "class_list": "", "function": "Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln) (By similarity). Also essential during biosynthesis of the molybdenum cofactor (PubMed:29491838). Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A (PubMed:26715182). Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus (By similarity). The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards URM1 and MOCS2A (By similarity). Subsequently, a transient disulfide bond is formed (PubMed:26715182). Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions (By similarity)., [UniProtKB, HAMAP, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M9PCK7;Q8T486", "ec_number_list": [ { "id": "2.7.7.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.80", "type": "external" }, { "id": "2.8.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.11", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016779 nucleotidyltransferase activity;GO:0004792 thiosulfate-cyanide sulfurtransferase activity;GO:0042292 URM1 activating enzyme activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1990133 molybdopterin adenylyltransferase complex", "go_biological_process": "GO:0002143 tRNA wobble position uridine thiolation;GO:0034227 tRNA thio-modification;GO:0006777 Mo-molybdopterin cofactor biosynthetic process;GO:0032324 molybdopterin cofactor biosynthetic process;GO:0032447 protein urmylation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VLJ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VLN1-1", "uniprot_id": [ { "id": "WDR82_DROME", "url": "https://www.uniprot.org/uniprot/Q9VLN1", "type": "external" } ], "mass": 35355.0, "length": 317, "protein_name": "WD repeat-containing protein 82", "gene_name": "Wdr82", "organism": "Fruit fly", "refseq_name": "WD repeat domain 82", "refseq_ac": [ { "id": "NP_609217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609217", "type": "external" } ], "gene_names_uniprotkb": "Wdr82; CG17293", "gene_names_refseq": "CG17293; Dmel\\CG17293; WDR82; Wdr82; dWdr82; wdr-82; wdr82", "protein_names_uniprotkb": "WD repeat-containing protein 82", "protein_names_refseq": "CG17293-PA; WD repeat domain 82; Wdr82-PA", "tax_id": 7227, "disease": "congenital heart disease (Disease Ontology:DOID:1682)", "pathway": " (dme:Dmel_CG17293); (R-DME-9772755); (R-DME-9930044)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "10731132;12537572;21694722;21875999;23295261;26577379", "class_list": "", "function": "Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 (PubMed:21694722, PubMed:21875999). Together with su(sable), part of a transcription termination checkpoint that promotes transcription termination of aberrant RNAs and their subsequent degradation by the nuclear exosome (PubMed:26577379)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0035097 histone methyltransferase complex;GO:0048188 Set1C/COMPASS complex", "go_biological_process": "GO:0032785 negative regulation of DNA-templated transcription, elongation;GO:0006338 chromatin remodeling;GO:0007507 heart development;GO:0006353 DNA-templated transcription termination;GO:0071027 nuclear RNA surveillance", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VLN1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VLP3-1", "uniprot_id": [ { "id": "MSS4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VLP3", "type": "external" } ], "mass": 14021.0, "length": 122, "protein_name": "Guanine nucleotide exchange factor MSS4 homolog", "gene_name": "strat", "organism": "Fruit fly", "refseq_name": "stratum", "refseq_ac": [ { "id": "NP_609209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609209", "type": "external" } ], "gene_names_uniprotkb": "strat; CG7787", "gene_names_refseq": "BcDNA:RE45155; CG7787; Dmel\\CG7787; Strat; strat", "protein_names_uniprotkb": "Guanine nucleotide exchange factor MSS4 homolog; Guanine nucleotide exchange factor stratum", "protein_names_refseq": "CG7787-PA; strat-PA; stratum", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7787)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;28228250", "class_list": "", "function": "Guanine-nucleotide-releasing protein that acts on members of the sec4/ypt1/rab subfamily such as Rab8. During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins such as trol/Pcan and vkg/Coll IV to the basal surface of follicular epithelial (FE) cells. Likely to function by restricting the activity of the vesicle transport regulator Rab8 to the basal membrane, and thus directs BM protein-containing vesicles to the basal side of the FE cells. This function is independent of the Crag/Rab10 regulation of polarized BM protein secretion in the FE., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IGQ8", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0045180 basal cortex;GO:0005829 cytosol;GO:0016020 membrane;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0015031 protein transport;GO:0007264 small GTPase-mediated signal transduction;GO:0006892 post-Golgi vesicle-mediated transport;GO:0061865 polarized secretion of basement membrane proteins in epithelium", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VLP3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VLP7-1", "uniprot_id": [ { "id": "MET14_DROME", "url": "https://www.uniprot.org/uniprot/Q9VLP7", "type": "external" } ], "mass": 44851.0, "length": 397, "protein_name": "N(6)-adenosine-methyltransferase non-catalytic subunit METTL14", "gene_name": "Mettl14", "organism": "Fruit fly", "refseq_name": "methyltransferase like 14", "refseq_ac": [ { "id": "NP_609205", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609205", "type": "external" } ], "gene_names_uniprotkb": "Mettl14; CG7818; KAR4", "gene_names_refseq": "CG7818; Dmel\\CG7818; METTL14; Mettl14; dKAR4; dMettl14; mettl14", "protein_names_uniprotkb": "N(6)-adenosine-methyltransferase non-catalytic subunit METTL14; Karyogamy protein 4; Methyltransferase-like protein 14; dMettl14", "protein_names_refseq": "CG7818-PA; Mettl14-PA; methyltransferase like 14", "tax_id": 7227, "disease": "traumatic brain injury (Disease Ontology:DOID:0081292)", "pathway": " (dme:Dmel_CG7818); (R-DME-72203)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10731132;12537569;12537572;27919077;27919081;28675155;29535189;29555755", "class_list": "", "function": "Non-catalytic component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination (PubMed:27919077, PubMed:28675155). In the heterodimer formed with Ime4/Mettl3, Mettl14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (By similarity). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy (PubMed:27919077, PubMed:28675155). M6A methylation is also required for neuronal functions (PubMed:27919077)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0016556 mRNA modification;GO:0030154 cell differentiation;GO:0008380 RNA splicing;GO:0007548 sex differentiation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VLP7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VLR9-1", "uniprot_id": [ { "id": "MPPE1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VLR9", "type": "external" } ], "mass": 43319.0, "length": 370, "protein_name": "Metallophosphoesterase 1 homolog", "gene_name": "PGAP5", "organism": "Fruit fly", "refseq_name": "Post-GPI attachment to proteins 5, isoform C", "refseq_ac": [ { "id": "NP_001260231", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260231", "type": "external" } ], "gene_names_uniprotkb": "PGAP5; CG8455", "gene_names_refseq": "CG8455; Dmel\\CG8455; PGAP5", "protein_names_uniprotkb": "Metallophosphoesterase 1 homolog; 3.1.-.-; Post-GPI attachment to proteins 5 ortholog", "protein_names_refseq": "CG8455-PC; PGAP5-PC; Post-GPI attachment to proteins 5 ortholog; Post-GPI attachment to proteins 5, isoform C", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8455)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Metallophosphoesterase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M9PF55;Q8T3Q1", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0062050 GPI-mannose ethanolamine phosphate phosphodiesterase activity", "go_cellular_component": "GO:0016020 membrane;GO:0070971 endoplasmic reticulum exit site;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VLR9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VLT1-1", "uniprot_id": [ { "id": "MON2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VLT1", "type": "external" } ], "mass": 186993.0, "length": 1684, "protein_name": "Protein MON2 homolog", "gene_name": "mon2", "organism": "Fruit fly", "refseq_name": "monensin sensitivity 2, isoform B", "refseq_ac": [ { "id": "NP_001033884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033884", "type": "external" } ], "gene_names_uniprotkb": "mon2; CG14276; CG31756; CG8683; Dmel\\CG8683; Dmel_CG8683; Mon2; noan", "gene_names_refseq": "CG14276; CG31756; CG8683; Dmel\\CG8683; Mon2; mon2; noan", "protein_names_uniprotkb": "Protein MON2 homolog", "protein_names_refseq": "CG8683-PB; mon2-PB; monensin sensitivity 2, isoform B; no anchor", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8683)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;16219684;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "May be required for traffic between late Golgi and early endosomes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8WHI7;Q961N6;Q9VLT2", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0005519 cytoskeletal regulatory protein binding", "go_cellular_component": "GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0031901 early endosome membrane", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0042147 retrograde transport, endosome to Golgi;GO:0006623 protein targeting to vacuole;GO:0007318 pole plasm protein localization;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VLT1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VLT8-1", "uniprot_id": [ { "id": "WASC3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VLT8", "type": "external" } ], "mass": 19501.0, "length": 176, "protein_name": "WASH complex subunit 3", "gene_name": "CCDC53", "organism": "Fruit fly", "refseq_name": "Coiled-coil domain containing 53", "refseq_ac": [ { "id": "NP_609178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609178", "type": "external" } ], "gene_names_uniprotkb": "CCDC53; CG7429", "gene_names_refseq": "CCDC53; CG7429; Ccdc53; Dmel\\CG7429; ccdc53", "protein_names_uniprotkb": "WASH complex subunit 3; Coiled-coil domain-containing protein 53 homolog", "protein_names_refseq": "CCDC53-PA; CG7429-PA; Coiled-coil domain containing 53", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7429)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;20498093;25739458", "class_list": "", "function": "Acts at least in part as component of the WASH complex which may regulate wash nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting (By similarity). During embryogenesis, not involved in the wash-dependent developmental migration of hemocytes anteriorly from the tail (PubMed:25739458)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SYM1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0031901 early endosome membrane;GO:0071203 WASH complex", "go_biological_process": "GO:0015031 protein transport;GO:0045785 positive regulation of cell adhesion;GO:0016197 endosomal transport;GO:0030041 actin filament polymerization;GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VLT8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VLW2-1", "uniprot_id": [ { "id": "KI26L_DROME", "url": "https://www.uniprot.org/uniprot/Q9VLW2", "type": "external" } ], "mass": 120722.0, "length": 1131, "protein_name": "Kinesin-like protein CG14535", "gene_name": "KIF26", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001285726", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285726", "type": "external" } ], "gene_names_uniprotkb": "KIF26; B; CG14535; DmKIF26; Dmel\\CG14535; Dmel_CG14535", "gene_names_refseq": "CG14535; DmKIF26; Dmel\\CG14535; KIF26A/B; KIF26", "protein_names_uniprotkb": "Kinesin-like protein CG14535", "protein_names_refseq": "CG14535-PB; Kinesin11; kinesin superfamily protein 26; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "complex cortical dysplasia with other brain malformations 11 (Disease Ontology:DOID:0061142)", "pathway": " (dme:Dmel_CG14535)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005874 microtubule", "go_biological_process": "GO:2001222 regulation of neuron migration", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VLW2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VLZ1-1", "uniprot_id": [ { "id": "Q9VLZ1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VLZ1", "type": "external" } ], "mass": 48311.0, "length": 429, "protein_name": "Peptidase M14 domain-containing protein", "gene_name": "Dmel\\CG7025", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_609133", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609133", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG7025; CG7025; Dmel_CG7025", "gene_names_refseq": "CG7025; Dmel\\CG7025", "protein_names_uniprotkb": "Peptidase M14 domain-containing protein", "protein_names_refseq": "CG7025-PA; uncharacterized protein", "tax_id": 7227, "disease": "pancreatitis (Disease Ontology:DOID:4989)", "pathway": " (dme:Dmel_CG7025)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Involved in the digestion of the blood meal., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VLZ1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VM21-1", "uniprot_id": [ { "id": "GUDU_DROME", "url": "https://www.uniprot.org/uniprot/Q9VM21", "type": "external" } ], "mass": 73181.0, "length": 669, "protein_name": "Armadillo repeat-containing protein gudu", "gene_name": "gudu", "organism": "Fruit fly", "refseq_name": "gudu", "refseq_ac": [ { "id": "NP_609111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609111", "type": "external" } ], "gene_names_uniprotkb": "gudu; CG5155", "gene_names_refseq": "CG5155; Dmel\\CG5155; Gudu; gudu", "protein_names_uniprotkb": "Armadillo repeat-containing protein gudu", "protein_names_refseq": "CG5155-PA; gudu-PA; gudu", "tax_id": 7227, "disease": "Kartagener syndrome (Disease Ontology:DOID:0050144); visceral heterotaxy (Disease Ontology:DOID:0050545); primary ciliary dyskinesia 23 (Disease Ontology:DOID:0110609)", "pathway": " (dme:Dmel_CG5155)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;24055424", "class_list": "", "function": "Important for spermatogenesis where it may have a role in sperm individualization., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NNW8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0070864 sperm individualization complex", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0007291 sperm individualization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VM21-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VM35-1", "uniprot_id": [ { "id": "U2QL1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VM35", "type": "external" } ], "mass": 33670.0, "length": 306, "protein_name": "Ubiquitin-conjugating enzyme E2Q-like protein CG4502", "gene_name": "CG4502", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform A", "refseq_ac": [ { "id": "NP_609103", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609103", "type": "external" } ], "gene_names_uniprotkb": "CG4502", "gene_names_refseq": "CG4502; Dmel\\CG4502; anon-WO0118547.403", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2Q-like protein CG4502; 2.3.2.23; E2Q-like ubiquitin-conjugating enzyme CG4502", "protein_names_refseq": "CG4502-PA; uncharacterized protein, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4502)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Catalyzes the covalent attachment of ubiquitin to other proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VM35-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VM71-1", "uniprot_id": [ { "id": "XRN2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VM71", "type": "external" } ], "mass": 103960.0, "length": 908, "protein_name": "5'-3' exoribonuclease 2 homolog", "gene_name": "Rat1", "organism": "Fruit fly", "refseq_name": "Rat1 5'-3' exoribonuclease, isoform B", "refseq_ac": [ { "id": "NP_001260166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001260166", "type": "external" } ], "gene_names_uniprotkb": "Rat1; CG10354; Xrn2", "gene_names_refseq": "CG10354; Dmel\\CG10354; RAT1; Rat1; XRN2; Xrn2; dRAT1; dhp1", "protein_names_uniprotkb": "5'-3' exoribonuclease 2 homolog; 3.1.13.-; Ribonucleic acid-trafficking protein 1; dRAT1", "protein_names_refseq": "CG10354-PB; Rat1 5'-3' exoribonuclease, isoform B; Rat1-PB", "tax_id": 7227, "disease": "adenoid cystic carcinoma (Disease Ontology:DOID:0080202); lung cancer (Disease Ontology:DOID:1324); status epilepticus (Disease Ontology:DOID:1824); leiomyosarcoma (Disease Ontology:DOID:1967)", "pathway": " (dme:Dmel_CG10354)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;17363252;18327897;27292797", "class_list": "", "function": "A 5'-3' exoribonuclease (PubMed:27292797). May promote the termination of transcription by RNA polymerase II and promote RNA degradation (PubMed:27292797). Involved in turnover of piRNA precursors (PubMed:27292797)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 4, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B8A3W7;M9PEY6;Q5BI90", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0004534 5'-3' RNA exonuclease activity;GO:0008409 5'-3' exonuclease activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0006369 termination of RNA polymerase II transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VM71-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VM75-1", "uniprot_id": [ { "id": "HEAT1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VM75", "type": "external" } ], "mass": 237220.0, "length": 2096, "protein_name": "HEAT repeat-containing protein 1 homolog", "gene_name": "Heatr1", "organism": "Fruit fly", "refseq_name": "lethal (2) k09022", "refseq_ac": [ { "id": "NP_609079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609079", "type": "external" } ], "gene_names_uniprotkb": "Heatr1; CG10805; l(2)k09022", "gene_names_refseq": "CG10805; Dmel\\CG10805; anon-WO0118547.160; l(2)k09022", "protein_names_uniprotkb": "HEAT repeat-containing protein 1 homolog", "protein_names_refseq": "CG10805-PA; l(2)k09022-PA; lethal (2) k09022", "tax_id": 7227, "disease": "glioblastoma (Disease Ontology:DOID:3068); pancreatic ductal carcinoma (Disease Ontology:DOID:3587)", "pathway": " (dme:Dmel_CG10805); (R-DME-6791226)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;38225354", "class_list": "", "function": "Ribosome biogenesis factor; required for recruitment of Myc to nucleoli (PubMed:38225354). Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). Involved in neuronal-lineage cell proliferation during larval development (PubMed:38225354)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6AWS0;Q8T9E7", "ec_number_list": [], "go_molecular_function": "GO:0030515 snoRNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0034455 t-UTP complex;GO:0030686 90S preribosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0045943 positive regulation of transcription by RNA polymerase I;GO:0061351 neural precursor cell proliferation;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0016072 rRNA metabolic process;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VM75-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VMA7-1", "uniprot_id": [ { "id": "TGO1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VMA7", "type": "external" } ], "mass": 159052.0, "length": 1430, "protein_name": "Transport and Golgi organization protein 1", "gene_name": "Tango1", "organism": "Fruit fly", "refseq_name": "transport and golgi organization 1, isoform A", "refseq_ac": [ { "id": "NP_609058", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_609058", "type": "external" } ], "gene_names_uniprotkb": "Tango1; 2L3443; CG11098; Dmel\\CG11098; Dmel_CG11098; TANGO1; tango1", "gene_names_refseq": "2L3443; CG11098; Dmel\\CG11098; TANGO1; Tango1; tango1", "protein_names_uniprotkb": "Transport and Golgi organization protein 1", "protein_names_refseq": "CG11098-PA; Tango1-PA; transport and golgi organisation 1; transport and golgi organization 1, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11098); (R-DME-381426); (R-DME-5694530); (R-DME-8957275)", "pathway_count": 4, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;16452979;17569856;17569867;18327897;23369713;25589440;26109356;26109357;40245499", "class_list": "", "function": "Required for protein secretion (PubMed:16452979, PubMed:23369713). May participate in cargo loading by binding to COPII coat subunits and guiding SH3-bound proteins into a growing carrier (PubMed:16452979). At basal transitional ER sites in follicle epithelial cells, mediates the exit of basal membrane protein such as vkg, LanB1 and Trol, from the endoplasmic reticulum (ER) to basal Golgi clusters (PubMed:23369713)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q8SY42;Q9VMA8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system;GO:0070971 endoplasmic reticulum exit site", "go_biological_process": "GO:0051047 positive regulation of secretion;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0009306 protein secretion;GO:0006887 exocytosis;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "Q9VMA7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VMK1-1", "uniprot_id": [ { "id": "UCP4C_DROME", "url": "https://www.uniprot.org/uniprot/Q9VMK1", "type": "external" } ], "mass": 38194.0, "length": 335, "protein_name": "Mitochondrial uncoupling protein 4C", "gene_name": "Ucp4C", "organism": "Fruit fly", "refseq_name": "uncoupling protein 4C", "refseq_ac": [ { "id": "NP_608976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608976", "type": "external" } ], "gene_names_uniprotkb": "Ucp4C; CG9064", "gene_names_refseq": "CG9064; DmUCP4C; Dmel\\CG9064; UCP4C; UCP4c; Ucp4C; Ucp4c; anon-WO02079478.1; anon-WO02079478.2; anon-WO0242455.3; anon-WO0242455.4; anon-WO03037362.7; anon-WO03061681.1; anon-WO03061681.2; dUCP4c; dmUCP4c; ucp4C; ucp4c", "protein_names_uniprotkb": "Mitochondrial uncoupling protein 4C", "protein_names_refseq": "CG9064-PA; Ucp4C-PA; uncoupling protein 4C", "tax_id": 7227, "disease": "schizophrenia (Disease Ontology:DOID:5419)", "pathway": " (dme:Dmel_CG9064)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;24639557", "class_list": "", "function": "Mitochondrial protein that is likely to be responsible for thermogenic respiration. Likely to function in mitochondrial uncoupling i.e. creating mitochondrial proton leaks across the inner mitochondrial membrane and can therefore dissipate the mitochondrial proton gradient and convert the energy of substrate oxidation into heat instead of ATP. Involved in cold tolerance, it is required for development to the adult stage at low temperatures., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0009409 response to cold", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VMK1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VMT5-1", "uniprot_id": [ { "id": "C28D1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VMT5", "type": "external" } ], "mass": 57271.0, "length": 502, "protein_name": "Probable cytochrome P450 28d1", "gene_name": "Cyp28d1", "organism": "Fruit fly", "refseq_name": "cytochrome P450 28d1", "refseq_ac": [ { "id": "NP_608912", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608912", "type": "external" } ], "gene_names_uniprotkb": "Cyp28d1; CG10833", "gene_names_refseq": "28d1; CG10833; CYP28d1; Cyp28d1; Dmel\\CG10833", "protein_names_uniprotkb": "Probable cytochrome P450 28d1; 1.14.-.-; CYPXXVIIID1", "protein_names_refseq": "CG10833-PA; Cyp28d1-PA; cytochrome P450 28d1; cytochrome P450", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10833)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VMT5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VMW7-1", "uniprot_id": [ { "id": "ITPA_DROME", "url": "https://www.uniprot.org/uniprot/Q9VMW7", "type": "external" } ], "mass": 21449.0, "length": 191, "protein_name": "Inosine triphosphate pyrophosphatase", "gene_name": "CG8891", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_608890", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608890", "type": "external" } ], "gene_names_uniprotkb": "CG8891", "gene_names_refseq": "CG8891; Dmel\\CG8891", "protein_names_uniprotkb": "Inosine triphosphate pyrophosphatase; 3.6.1.66; ITPase; Inosine triphosphatase; NTPase; Non-canonical purine NTP pyrophosphatase; Non-standard purine NTP pyrophosphatase; Nucleoside-triphosphate diphosphatase; Nucleoside-triphosphate pyrophosphatase; XTP/dITP diphosphatase", "protein_names_refseq": "CG8891-PA; uncharacterized protein", "tax_id": 7227, "disease": "developmental and epileptic encephalopathy 35 (Disease Ontology:DOID:0080458); thrombocytopenia (Disease Ontology:DOID:1588); hepatitis C (Disease Ontology:DOID:1883); anemia (Disease Ontology:DOID:2355); hemolytic anemia (Disease Ontology:DOID:583); rheumatoid arthritis (Disease Ontology:DOID:7148); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)", "pathway": " (dme:Dmel_CG8891); (R-DME-74259); (R-DME-9755088)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;40245499", "class_list": "", "function": "Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.66", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.66", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0047429 nucleoside triphosphate diphosphatase activity;GO:0035870 dITP diphosphatase activity;GO:0036220 ITP diphosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009117 nucleotide metabolic process;GO:0009143 nucleoside triphosphate catabolic process;GO:0009204 deoxyribonucleoside triphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VMW7-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VMW8-1", "uniprot_id": [ { "id": "MPU1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VMW8", "type": "external" } ], "mass": 27546.0, "length": 252, "protein_name": "Mannose-P-dolichol utilization defect 1 protein homolog", "gene_name": "CG3792", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_608889", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608889", "type": "external" } ], "gene_names_uniprotkb": "CG3792", "gene_names_refseq": "CG3792; Dmel\\CG3792; anon-EST:Posey8", "protein_names_uniprotkb": "Mannose-P-dolichol utilization defect 1 protein homolog", "protein_names_refseq": "CG3792-PA; uncharacterized protein", "tax_id": 7227, "disease": "congenital disorder of glycosylation If (Disease Ontology:DOID:0080558)", "pathway": " (dme:Dmel_CG3792); (R-DME-446193)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0009312 oligosaccharide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VMW8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VMX1-1", "uniprot_id": [ { "id": "KBP_DROME", "url": "https://www.uniprot.org/uniprot/Q9VMX1", "type": "external" } ], "mass": 69685.0, "length": 600, "protein_name": "KIF-binding protein", "gene_name": "CG14043", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_608886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608886", "type": "external" } ], "gene_names_uniprotkb": "CG14043", "gene_names_refseq": "CG14043; Dmel\\CG14043", "protein_names_uniprotkb": "KIF-binding protein; Protein KBP", "protein_names_refseq": "CG14043-PA; uncharacterized protein", "tax_id": 7227, "disease": "Goldberg-Shprintzen syndrome (Disease Ontology:DOID:0060481)", "pathway": " (dme:Dmel_CG14043)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NP90", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005856 cytoskeleton", "go_biological_process": "GO:0047497 mitochondrion transport along microtubule;GO:1990535 neuron projection maintenance;GO:0021952 central nervous system projection neuron axonogenesis;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VMX1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VMY2-1", "uniprot_id": [ { "id": "Q9VMY2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VMY2", "type": "external" } ], "mass": 42669.0, "length": 378, "protein_name": "Sayonara", "gene_name": "synr", "organism": "Fruit fly", "refseq_name": "sayonara", "refseq_ac": [ { "id": "NP_608879", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608879", "type": "external" } ], "gene_names_uniprotkb": "synr; CG14044; Dmel\\CG14044; Dmel_CG14044", "gene_names_refseq": "CG14044; Dmel\\CG14044; synr", "protein_names_uniprotkb": "Sayonara", "protein_names_refseq": "CG14044-PA; sayonara; synr-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14044)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0097136 Bcl-2 family protein complex", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0010508 positive regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VMY2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VN25-1", "uniprot_id": [ { "id": "EIF3A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VN25", "type": "external" } ], "mass": 133880.0, "length": 1140, "protein_name": "Eukaryotic translation initiation factor 3 subunit A", "gene_name": "eIF3a", "organism": "Fruit fly", "refseq_name": "eukaryotic translation initiation factor 3 subunit a, isoform A", "refseq_ac": [ { "id": "NP_649470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649470", "type": "external" } ], "gene_names_uniprotkb": "eIF3a; CG9805; eIF3-S10", "gene_names_refseq": "CG9805; Dmel\\CG9805; EIF3-S10; MMAP140; anon-WO0118547.261; eIF3 S10; eIF3-S10; eIF3-s10; eIF3a; eIF3", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit A; Eukaryotic translation initiation factor 3 subunit 10; eIF3a", "protein_names_refseq": "CG9805-PA; eIF3-S10; eIF3a-PA; eukaryotic translation initiation factor 3 subunit a, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9805); (R-DME-156827); (R-DME-72649); (R-DME-72689); (R-DME-72695); (R-DME-72702)", "pathway_count": 6, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;17392269;18327897", "class_list": "", "function": "RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0KID1;Q494J3;Q8IH03;Q8SYE5", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0043614 multi-eIF complex;GO:0071540 eukaryotic translation initiation factor 3 complex, eIF3e", "go_biological_process": "GO:0002188 translation reinitiation;GO:0006413 translational initiation;GO:0006446 regulation of translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VN25-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VN97-1", "uniprot_id": [ { "id": "TI17D_DROME", "url": "https://www.uniprot.org/uniprot/Q9VN97", "type": "external" } ], "mass": 24166.0, "length": 224, "protein_name": "Probable mitochondrial import inner membrane translocase subunit Tim17 4", "gene_name": "Tim17a2", "organism": "Fruit fly", "refseq_name": "Tim17a2", "refseq_ac": [ { "id": "NP_649524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649524", "type": "external" } ], "gene_names_uniprotkb": "Tim17a2; CG14666", "gene_names_refseq": "BcDNA:RH03914; CG14666; Dmel\\CG14666; Tim17a2", "protein_names_uniprotkb": "Probable mitochondrial import inner membrane translocase subunit Tim17 4", "protein_names_refseq": "CG14666-PA; Tim17a2-PA; Tim17a2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14666); (R-DME-1268020)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005744 TIM23 mitochondrial import inner membrane translocase complex", "go_biological_process": "GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VN97-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VNB3-1", "uniprot_id": [ { "id": "OR83A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VNB3", "type": "external" } ], "mass": 52272.0, "length": 453, "protein_name": "Odorant receptor 83a", "gene_name": "Or83a", "organism": "Fruit fly", "refseq_name": "odorant receptor 83a", "refseq_ac": [ { "id": "NP_524234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524234", "type": "external" } ], "gene_names_uniprotkb": "Or83a; CG10612", "gene_names_refseq": "83A.1; 83a; CG10612; DOR44; Dmel\\CG10612; Or83a", "protein_names_uniprotkb": "Odorant receptor 83a", "protein_names_refseq": "CG10612-PA; Or83a-PA; odorant receptor 83a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10612)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;21857978", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to pentanol, ethyl acetate, and propyl acetate., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0032590 dendrite membrane", "go_biological_process": "GO:0042048 olfactory behavior;GO:0007165 signal transduction;GO:0008104 intracellular protein localization;GO:0007608 sensory perception of smell;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VNB3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VNC1-1", "uniprot_id": [ { "id": "Q9VNC1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VNC1", "type": "external" } ], "mass": 36251.0, "length": 321, "protein_name": "Large ribosomal subunit protein mL44", "gene_name": "mRpL44", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein L44", "refseq_ac": [ { "id": "NP_649541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649541", "type": "external" } ], "gene_names_uniprotkb": "mRpL44; CG2109; Dmel\\CG2109; Dmel_CG2109; MRP-L44", "gene_names_refseq": "CG2109; Dmel\\CG2109; MRP-L44; mRpL44", "protein_names_uniprotkb": "Large ribosomal subunit protein mL44", "protein_names_refseq": "CG2109-PA; mRpL44-PA; mitochondrial ribosomal protein L44", "tax_id": 7227, "disease": "combined oxidative phosphorylation deficiency 16 (Disease Ontology:DOID:0111469)", "pathway": " (dme:Dmel_CG2109); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003725 double-stranded RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005634 nucleus", "go_biological_process": "GO:0006396 RNA processing;GO:0070125 mitochondrial translational elongation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VNC1-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VNE4-1", "uniprot_id": [ { "id": "Q9VNE4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VNE4", "type": "external" } ], "mass": 116592.0, "length": 994, "protein_name": "Asterless", "gene_name": "asl", "organism": "Fruit fly", "refseq_name": "asterless", "refseq_ac": [ { "id": "NP_649557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649557", "type": "external" } ], "gene_names_uniprotkb": "asl; ASL; Asl; CG2919; Cep152; DmAsl; Dmel\\CG2919; Dmel_CG2919; MecD; mecD; sdu", "gene_names_refseq": "ASL; Asl; CG2919; Cep152; DmAsl; Dmel\\CG2919; MecD; asl; mecD; sdu", "protein_names_uniprotkb": "Asterless", "protein_names_refseq": "CG2919-PA; asl-PA; asterless; mechanosensory D; mechanosensory mutant D; star dust", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2919)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7YTY4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005815 microtubule organizing center;GO:0005814 centriole;GO:0036064 ciliary basal body;GO:0000242 pericentriolar material", "go_biological_process": "GO:0007338 single fertilization;GO:0007098 centrosome cycle;GO:1905515 non-motile cilium assembly;GO:0008356 asymmetric cell division;GO:1903723 negative regulation of centriole elongation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VNE4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VNI3-1", "uniprot_id": [ { "id": "HPF1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VNI3", "type": "external" } ], "mass": 51100.0, "length": 449, "protein_name": "Histone PARylation factor 1", "gene_name": "Hpf1", "organism": "Fruit fly", "refseq_name": "histone PARylation factor 1", "refseq_ac": [ { "id": "NP_649589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649589", "type": "external" } ], "gene_names_uniprotkb": "Hpf1; CG1218", "gene_names_refseq": "CG1218; Dmel\\CG1218; Hpf1; dHpf1", "protein_names_uniprotkb": "Histone PARylation factor 1", "protein_names_refseq": "CG1218-PA; Hpf1-PA; histone PARylation factor 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1218)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;18327897;20088964;37268618", "class_list": "", "function": "Cofactor for serine ADP-ribosylation that confers serine specificity on Parp1 and may play a key role in DNA damage response (PubMed:37268618). Switches the amino acid specificity of Parp1 from aspartate or glutamate to serine residues, licensing serine ADP-ribosylation of target proteins (By similarity). Acts by completing the active site of Parp1; forms a composite active site composed of residues from Hpf1 and Parp1 (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 4, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8T050", "ec_number_list": [], "go_molecular_function": "GO:0072572 poly-ADP-D-ribose binding;GO:0008270 zinc ion binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0090734 site of DNA damage", "go_biological_process": "GO:0006974 DNA damage response;GO:0006302 double-strand break repair;GO:0140861 DNA repair-dependent chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VNI3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VP65-1", "uniprot_id": [ { "id": "TR112_DROME", "url": "https://www.uniprot.org/uniprot/Q9VP65", "type": "external" } ], "mass": 13920.0, "length": 124, "protein_name": "Multifunctional methyltransferase subunit TRM112-like protein", "gene_name": "Trmt112", "organism": "Fruit fly", "refseq_name": "tRNA methyltransferase subunit 11-2", "refseq_ac": [ { "id": "NP_649293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649293", "type": "external" } ], "gene_names_uniprotkb": "Trmt112; CG12975", "gene_names_refseq": "BcDNA:RE57810; CG12975; Dmel\\CG12975; Trmt112", "protein_names_uniprotkb": "Multifunctional methyltransferase subunit TRM112-like protein; tRNA methyltransferase 112 homolog; tRNA methyltransferase subunit 11-2", "protein_names_refseq": "CG12975-PA; Trmt112-PA; tRNA methyltransferase subunit 11-2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12975); (R-DME-156581); (R-DME-72764)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;32350990", "class_list": "", "function": "Acts as an activator of both RNA and protein methyltransferases (By similarity). Together with methyltransferase Mettl5, specifically methylates the 6th position of adenine in 18S rRNA (PubMed:32350990)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1B2AL65", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0141106 tRNA methyltransferase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0043528 tRNA (m2G10) methyltransferase complex", "go_biological_process": "GO:0031167 rRNA methylation;GO:2000234 positive regulation of rRNA processing;GO:0030490 maturation of SSU-rRNA;GO:0000470 maturation of LSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VP65-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VPD5-1", "uniprot_id": [ { "id": "MTEF3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VPD5", "type": "external" } ], "mass": 41267.0, "length": 354, "protein_name": "Transcription termination factor 3, mitochondrial", "gene_name": "mTerf3", "organism": "Fruit fly", "refseq_name": "mitochondrial transcription termination factor 3", "refseq_ac": [ { "id": "NP_649240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649240", "type": "external" } ], "gene_names_uniprotkb": "mTerf3; CG5047", "gene_names_refseq": "CG5047; D-MTERF3; DmMTERF3; DmMterf3; Dmel\\CG5047; MTERF3; Mterf3; mTerf3", "protein_names_uniprotkb": "Transcription termination factor 3, mitochondrial; Mitochondrial transcription termination factor 3; mTerf3", "protein_names_refseq": "CG5047-PA; mTerf3-PA; mitochondrial transcription termination factor 3; mitochondrial transcription termination factor", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG5047); (R-DME-5205685)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;16787637;23300484", "class_list": "", "function": "Binds promoter DNA and regulates initiation of transcription (By similarity). Regulator of mitochondrial ribosome biogenesis and translation that is essential for development (PubMed:16787637, PubMed:23300484). Required for normal mitochondrial transcription and translation (PubMed:16787637, PubMed:23300484). Required for assembly of mitochondrial respiratory complexes and normal mitochondrial function (PubMed:23300484). Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (PubMed:23300484)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q06YR8", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:1902775 mitochondrial large ribosomal subunit assembly;GO:0061668 mitochondrial ribosome assembly;GO:1903108 regulation of mitochondrial transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VPD5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VPE4-1", "uniprot_id": [ { "id": "VMA21_DROME", "url": "https://www.uniprot.org/uniprot/Q9VPE4", "type": "external" } ], "mass": 11397.0, "length": 105, "protein_name": "Vacuolar ATPase assembly integral membrane protein VMA21 homolog", "gene_name": "CG5969", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_788549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788549", "type": "external" } ], "gene_names_uniprotkb": "CG5969", "gene_names_refseq": "BcDNA:GM09417; BcDNA:RE53796; CG32426; CG5969; Dmel\\CG5969", "protein_names_uniprotkb": "Vacuolar ATPase assembly integral membrane protein VMA21 homolog", "protein_names_refseq": "CG5969-PA; uncharacterized protein", "tax_id": 7227, "disease": "X-linked myopathy with excessive autophagy (Disease Ontology:DOID:0050760); follicular lymphoma (Disease Ontology:DOID:0050873)", "pathway": " (dme:Dmel_CG5969)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8T3M1;Q9VPE5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0012507 ER to Golgi transport vesicle membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VPE4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VPH0-1", "uniprot_id": [ { "id": "INTU_DROME", "url": "https://www.uniprot.org/uniprot/Q9VPH0", "type": "external" } ], "mass": 98133.0, "length": 869, "protein_name": "Protein inturned", "gene_name": "in", "organism": "Fruit fly", "refseq_name": "inturned", "refseq_ac": [ { "id": "NP_788548", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788548", "type": "external" } ], "gene_names_uniprotkb": "in; CG16993", "gene_names_refseq": "B; CG16993; Dmel\\CG16993; In; in", "protein_names_uniprotkb": "Protein inturned", "protein_names_refseq": "CG16993-PA; in-PA; inturned; intwined; transcript B", "tax_id": 7227, "disease": "asphyxiating thoracic dystrophy (Disease Ontology:DOID:0050592); orofaciodigital syndrome XVII (Disease Ontology:DOID:0080289)", "pathway": " (dme:Dmel_CG16993); (R-DME-450728); (R-DME-5610787)", "pathway_count": 3, "publication_count": 11, "publication_id_list": "10570461;10731132;11973308;12537569;12537572;15556868;18701542;18723886;19576201;20351219;8631273", "class_list": "", "function": "Plays a role in the definition of cell polarity via the planar cell polarity (PCP) cascade. Acts downstream of fuz and accumulates asymmetrically in wing cells to regulate planar polarity in the wing. Probably acts by regulating ciliogenesis., [UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q24144", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0007399 nervous system development;GO:0060271 cilium assembly;GO:0016192 vesicle-mediated transport;GO:0035316 non-sensory hair organization;GO:0001737 establishment of imaginal disc-derived wing hair orientation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VPH0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VPK4-1", "uniprot_id": [ { "id": "Q9VPK4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VPK4", "type": "external" } ], "mass": 27626.0, "length": 238, "protein_name": "RRM domain-containing protein", "gene_name": "dRbm7", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_608497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608497", "type": "external" } ], "gene_names_uniprotkb": "dRbm7; CG11454; Dmel\\CG11454; Dmel_CG11454; cg11454", "gene_names_refseq": "CG11454; Dmel\\CG11454; cg11454; dRbm7", "protein_names_uniprotkb": "RRM domain-containing protein", "protein_names_refseq": "CG11454-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11454); (R-DME-9930044)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003727 single-stranded RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VPK4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VPM5-1", "uniprot_id": [ { "id": "MBM_DROME", "url": "https://www.uniprot.org/uniprot/Q9VPM5", "type": "external" } ], "mass": 58629.0, "length": 539, "protein_name": "Protein mushroom body miniature", "gene_name": "mbm", "organism": "Fruit fly", "refseq_name": "mushroom body miniature", "refseq_ac": [ { "id": "NP_608511", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608511", "type": "external" } ], "gene_names_uniprotkb": "mbm; CG11604", "gene_names_refseq": "CG11604; Dmel\\CG11604; mbm; mus", "protein_names_uniprotkb": "Protein mushroom body miniature", "protein_names_refseq": "CG11604-PA; MB miniature; mbm-PA; mushroom bodies miniature; mushroom bodies small; mushroom body miniature; mushroom-body-miniature", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11604)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;15375215;24615015", "class_list": "", "function": "Required for small ribosomal subunit biogenesis in neuroblasts (PubMed:24615015). Plays a role in mushroom body development (PubMed:15375215)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 6, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007612 learning;GO:0007628 adult walking behavior;GO:0008355 olfactory learning;GO:0007632 visual behavior;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VPM5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VPT1-1", "uniprot_id": [ { "id": "GR21A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VPT1", "type": "external" } ], "mass": 51908.0, "length": 447, "protein_name": "Gustatory and odorant receptor 21a", "gene_name": "Gr21a", "organism": "Fruit fly", "refseq_name": "gustatory receptor 21a, isoform B", "refseq_ac": [ { "id": "NP_001259841", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259841", "type": "external" } ], "gene_names_uniprotkb": "Gr21a; CG13948; GR21D.1", "gene_names_refseq": "(GR) 21a; 21D.1; CG13948; DmGr21a; Dmel\\CG13948; GR21D.1; GR21D1; GR21a; Gr21D1; Gr21a; gr21a", "protein_names_uniprotkb": "Gustatory and odorant receptor 21a", "protein_names_refseq": "CG13948-PB; Gr21a-PB; gustatory receptor 21D.1; gustatory receptor 21a, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13948)", "pathway_count": 1, "publication_count": 13, "publication_id_list": "10710312;10731132;11516643;12537572;16809465;17167414;17360684;17493811;19710651;22031876;23105004;23162431;23185459", "class_list": "", "function": "Gustatory and odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr21a and Gr63a together are sufficient for carbon dioxide detection and avoidance behavior. It is possible that the CO(2) receptors Gr63a and Gr21a activate the TRPC channels through Galpha49B and Plc21C. This innate olfactory avoidance behavior can be inhibited by inhibitory interactions of the odors such as 1-hexanol and 2,3-butanedione with Gr21a and Gr63a., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1C3L0;M9PAZ2;Q1WW99", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0004984 olfactory receptor activity;GO:0008527 taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007165 signal transduction;GO:0034220 monoatomic ion transmembrane transport;GO:0050909 sensory perception of taste;GO:0010037 response to carbon dioxide;GO:0003031 detection of carbon dioxide", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VPT1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VPU8-1", "uniprot_id": [ { "id": "KRR1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VPU8", "type": "external" } ], "mass": 39843.0, "length": 345, "protein_name": "KRR1 small subunit processome component homolog", "gene_name": "dbe", "organism": "Fruit fly", "refseq_name": "dribble", "refseq_ac": [ { "id": "NP_477240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477240", "type": "external" } ], "gene_names_uniprotkb": "dbe; CG4258; dribble", "gene_names_refseq": "CG4258; DBE; Dmel\\CG4258; dbe; l(2)k05428; l(2)k06708", "protein_names_uniprotkb": "KRR1 small subunit processome component homolog; KRR-R motif-containing protein 1; Protein dribble", "protein_names_refseq": "CG4258-PA; dbe-PA; dribble", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4258); (R-DME-6791226)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;11359931;12537572;16542639", "class_list": "", "function": "Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Binds to RNA. Required for female germline development, cell viability during eye development and for survival of dividing cells and epithelial cells during early wing disk development., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O02394", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:1990904 ribonucleoprotein complex;GO:0032040 small-subunit processome", "go_biological_process": "GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VPU8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VPW8-1", "uniprot_id": [ { "id": "PINO_DROME", "url": "https://www.uniprot.org/uniprot/Q9VPW8", "type": "external" } ], "mass": 26306.0, "length": 249, "protein_name": "Protein pinocchio", "gene_name": "Pino", "organism": "Fruit fly", "refseq_name": "pinocchio, isoform C", "refseq_ac": [ { "id": "NP_001259854", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259854", "type": "external" } ], "gene_names_uniprotkb": "Pino; CG4710; smi21F", "gene_names_refseq": "CG4710; Dmel\\CG4710; Pino; anon-WO0118547.131; smi21F", "protein_names_uniprotkb": "Protein pinocchio", "protein_names_refseq": "CG4710-PC; Pino-PC; pinocchio, isoform C; pinocchio; smell impaired 21 F; smell impaired 21F; smell imparied 21 F", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4710)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;15719418", "class_list": "", "function": "Plays a role in olfaction., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8T0A4;Q9VPW7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0042048 olfactory behavior;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VPW8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VQ62-1", "uniprot_id": [ { "id": "NPC2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VQ62", "type": "external" } ], "mass": 16021.0, "length": 148, "protein_name": "NPC intracellular cholesterol transporter 2 homolog a", "gene_name": "Npc2a", "organism": "Fruit fly", "refseq_name": "Niemann-Pick type C-2a", "refseq_ac": [ { "id": "NP_608637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608637", "type": "external" } ], "gene_names_uniprotkb": "Npc2a; CG7291; NPC2", "gene_names_refseq": "BEST:GH08376; BcDNA:GH22047; BcDNA:RH53228; CG7291; CT22505; DmML3; Dmel\\CG7291; NPC2; Npc2a; dnpc2a; npc2a", "protein_names_uniprotkb": "NPC intracellular cholesterol transporter 2 homolog a; Niemann Pick type C2 protein homolog", "protein_names_refseq": "CG7291-PA; Niemann-Pick type C-2a; Niemann-Pick type C-2; Npc2a-PA; epididymal secretory protein", "tax_id": 7227, "disease": "Niemann-Pick disease type C2 (Disease Ontology:DOID:0070114); Niemann-Pick disease (Disease Ontology:DOID:14504)", "pathway": " (dme:Dmel_CG7291)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;17804599;40245499", "class_list": "", "function": "Functions redundantly with Npc2b in regulating sterol homeostasis and ecdysteroid biosynthesis, probably by controlling the availability of sterol substrate., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042834 peptidoglycan binding;GO:0015485 cholesterol binding;GO:0001530 lipopolysaccharide binding;GO:0032934 sterol binding;GO:0070891 lipoteichoic acid binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0032367 intracellular cholesterol transport;GO:1900426 positive regulation of defense response to bacterium;GO:0015918 sterol transport;GO:0055092 sterol homeostasis;GO:0008039 synaptic target recognition", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VQ62-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VQ89-1", "uniprot_id": [ { "id": "MIO_DROME", "url": "https://www.uniprot.org/uniprot/Q9VQ89", "type": "external" } ], "mass": 98602.0, "length": 867, "protein_name": "GATOR2 complex protein Mio", "gene_name": "mio", "organism": "Fruit fly", "refseq_name": "missing oocyte", "refseq_ac": [ { "id": "NP_608656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608656", "type": "external" } ], "gene_names_uniprotkb": "mio; CG7074", "gene_names_refseq": "CG15384; CG7074; Dmel\\CG7074; FBtr0077835; GATOR2; Mio; SEA4; Sea4; mio", "protein_names_uniprotkb": "GATOR2 complex protein Mio; Protein missing oocyte", "protein_names_refseq": "CG7074-PA; mio-PA; missing oocyte", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7074)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10731132;12537569;12537572;14973288;21521741;23723238;25512509;27166823;38514639", "class_list": "", "function": "An essential component of the GATOR subcomplex GATOR2 which functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:27166823). The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the mTORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:23723238, PubMed:27166823). GATOR2 activates the mTORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation and growth under nutrient replete conditions and during female oocyte development (PubMed:14973288, PubMed:21521741, PubMed:23723238, PubMed:25512509). This component is required for activating mTORC1 specifically in germline cells to promote cell growth and maintain the oocyte fate (PubMed:21521741, PubMed:23723238, PubMed:27166823). GATOR1 and GATOR2 act at different stages of oogenesis to regulate mTORC1 in order to control meiotic entry and promote oocyte growth and development (PubMed:14973288, PubMed:21521741, PubMed:23723238, PubMed:25512509). After exactly four mitotic cyst divisions, the GATOR1 complex members (Iml1, Nprl2 and Nprl3) down-regulate mTORC1 to slow cellular metabolism and promote the mitotic/meiotic transition (PubMed:25512509). At later stages of oogenesis, the mio and Nup44A components of the GATOR2 complex inhibit GATOR1 and thus activate mTORC1 to promote meiotic progression, and drive oocyte growth and development (PubMed:21521741, PubMed:25512509). In addition to its role in the regulation of the mTORC1 complex, functions independently of mTORC1 to prevent the inappropriate accumulation of autolysosomes in germline tissues (PubMed:27166823)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95RC2", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005764 lysosome;GO:0032991 protein-containing complex;GO:0044754 autolysosome", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0009994 oocyte differentiation;GO:0051301 cell division;GO:0006302 double-strand break repair;GO:0010507 negative regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9VQ89-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VQE8-1", "uniprot_id": [ { "id": "Q9VQE8_DROME", "url": "https://www.uniprot.org/uniprot/Q9VQE8", "type": "external" } ], "mass": 35183.0, "length": 305, "protein_name": "TBP-related factor 5", "gene_name": "Trf5", "organism": "Fruit fly", "refseq_name": "TBP-related factor 5", "refseq_ac": [ { "id": "NP_608700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608700", "type": "external" } ], "gene_names_uniprotkb": "Trf5; CG15398; Dmel\\CG15398; Dmel_CG15398; trf5", "gene_names_refseq": "CG15398; Dmel\\CG15398; Trf5; trf5", "protein_names_uniprotkb": "TBP-related factor 5", "protein_names_refseq": "CG15398-PB; TBP-related factor 5; Trf5-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15398)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "", "go_biological_process": "GO:0006352 DNA-templated transcription initiation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VQE8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VQM4-1", "uniprot_id": [ { "id": "TYDP1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VQM4", "type": "external" } ], "mass": 64194.0, "length": 580, "protein_name": "Tyrosyl-DNA phosphodiesterase 1", "gene_name": "Tdp1", "organism": "Fruit fly", "refseq_name": "glaikit", "refseq_ac": [ { "id": "NP_523465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523465", "type": "external" } ], "gene_names_uniprotkb": "Tdp1; CG8825; CG8826; gkt", "gene_names_refseq": "CG8825; CG8826; Dmel\\CG8825; Gkt; Glaikit; TDP1; Tdp1; anon-23Db; c22; gkt", "protein_names_uniprotkb": "Tyrosyl-DNA phosphodiesterase 1; 3.1.4.-; Protein glaikit; Tyr-DNA phosphodiesterase", "protein_names_refseq": "CG8825-PA; Tyrosyl-DNA phosophodiesterase 1; Tyrosyl-DNA phosphodiesterase 1; anon-23Db; gkt-PA; glaikit", "tax_id": 7227, "disease": "spinocerebellar ataxia with axonal neuropathy 1 (Disease Ontology:DOID:0090115)", "pathway": " (dme:Dmel_CG8825)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10731132;10940635;12537569;12537572;15556867;25331878;28465232", "class_list": "", "function": "DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate (PubMed:25331878). Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate (By similarity). Required for normal polarization of epidermal cells, correct subcellular location of the Crb complex to the apical lateral membrane, and for normal neuronal development during embryonic development (PubMed:15556867). Contributes to maintenance of epithelial cells in response to topoisomerase-1-mediated and oxidative DNA damage (PubMed:25331878). Required for precise axonal bifurcation in mushroom body neurons (PubMed:28465232). Required for maintenance of normal neuronal function (PubMed:25331878)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95SG3;Q9NFM9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003690 double-stranded DNA binding;GO:0004527 exonuclease activity;GO:0003697 single-stranded DNA binding;GO:0017005 3'-tyrosyl-DNA phosphodiesterase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0007417 central nervous system development;GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9VQM4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VQP9-1", "uniprot_id": [ { "id": "OSTC_DROME", "url": "https://www.uniprot.org/uniprot/Q9VQP9", "type": "external" } ], "mass": 16823.0, "length": 149, "protein_name": "Oligosaccharyltransferase complex subunit C", "gene_name": "Ostc", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001259997", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259997", "type": "external" } ], "gene_names_uniprotkb": "Ostc; CG9662", "gene_names_refseq": "BcDNA:AT03617; CG9662; Dmel\\CG9662", "protein_names_uniprotkb": "Oligosaccharyltransferase complex subunit C", "protein_names_refseq": "CG9662-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9662)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E0R7Q5;Q7K050;Q8T985", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0008250 oligosaccharyltransferase complex;GO:0160226 oligosaccharyltransferase complex A", "go_biological_process": "GO:0006487 protein N-linked glycosylation;GO:0180058 protein co-translational transfer of dolichol-linked oligosaccharide", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VQP9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VQS5-1", "uniprot_id": [ { "id": "IFT57_DROME", "url": "https://www.uniprot.org/uniprot/Q9VQS5", "type": "external" } ], "mass": 47173.0, "length": 405, "protein_name": "Intraflagellar transport protein 57 homolog", "gene_name": "IFT57", "organism": "Fruit fly", "refseq_name": "intraflagellar transport 57", "refseq_ac": [ { "id": "NP_608792", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608792", "type": "external" } ], "gene_names_uniprotkb": "IFT57; CG8853; Che-13", "gene_names_refseq": "CG8853; CHE-13; Che-13; Dmel\\CG8853; Hippi; IFT55; IFT57; che-13", "protein_names_uniprotkb": "Intraflagellar transport protein 57 homolog", "protein_names_refseq": "CG8853-PA; Che-13 ortholog; IFT57-PA; hippi; intraflagellar transport 57", "tax_id": 7227, "disease": "ciliopathy (Disease Ontology:DOID:0060340); orofaciodigital syndrome XVIII (Disease Ontology:DOID:0060961)", "pathway": " (dme:Dmel_CG8853); (R-DME-5610787)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Required for the formation of cilia., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D6W4R8;S5MIX7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005929 cilium;GO:0005815 microtubule organizing center;GO:0036064 ciliary basal body;GO:0030992 intraciliary transport particle B", "go_biological_process": "GO:0006915 apoptotic process;GO:0060271 cilium assembly;GO:0042981 regulation of apoptotic process;GO:1905515 non-motile cilium assembly;GO:0042073 intraciliary transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VQS5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VQW6-1", "uniprot_id": [ { "id": "Q9VQW6_DROME", "url": "https://www.uniprot.org/uniprot/Q9VQW6", "type": "external" } ], "mass": 10759.0, "length": 95, "protein_name": "Uncharacterized protein", "gene_name": "CG10039", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_608816", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608816", "type": "external" } ], "gene_names_uniprotkb": "CG10039; CG43774; Dmel\\CG43774; Dmel_CG43774", "gene_names_refseq": "CG10039; CG43774; Dmel\\CG43774", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG43774-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG43774)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VQW6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VQZ6-1", "uniprot_id": [ { "id": "ELP3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VQZ6", "type": "external" } ], "mass": 62821.0, "length": 552, "protein_name": "Elongator complex protein 3", "gene_name": "Elp3", "organism": "Fruit fly", "refseq_name": "elongator complex protein 3", "refseq_ac": [ { "id": "NP_608834", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608834", "type": "external" } ], "gene_names_uniprotkb": "Elp3; CG15433", "gene_names_refseq": "CG15433; D-elp3; Dmel/ELP3; Dmel\\CG15433; Dmel\\ELP3; ELP3; Elp3; HAT; dmHAG408; elp-3; elp3", "protein_names_uniprotkb": "Elongator complex protein 3; 2.3.1.311; 2.3.1.48; tRNA uridine(34) acetyltransferase", "protein_names_refseq": "CG15433-PA; Elp3-PA; elongator complex protein 3; elongator protein 3", "tax_id": 7227, "disease": "familial dysautonomia (Disease Ontology:DOID:11589)", "pathway": " (dme:Dmel_CG15433)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;12537569;12537572;20626565;21288872;22153374;29545390;36302967", "class_list": "", "function": "Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:36302967). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:36302967). Can acetylate proteins including histone H3 and brp/bruchpilot but is not a major acetyltransferase of tubulin; acetylation of brp plays a role in maintaining the organization of the presynaptic active zone (PubMed:22153374). Binding by the elongator complex stabilizes microtubules and promotes their growth (PubMed:36302967). This induces central spindle asymmetry, promoting polarized signaling endosome trafficking during asymmetric cell division and cell fate assignation of sensory organ precursor cells (PubMed:36302967). Required in both motoneurons and muscles to maintain the organization of presynaptic active zones and postsynaptic glutamate receptor clusters (PubMed:22153374). Plays a role in the control of synaptic bouton expansion (PubMed:20626565). Required for larval development (PubMed:21288872). Involved in protein synthesis-dependent long-term memory formation, probably as part of the elongator complex (PubMed:29545390)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" }, { "id": "2.3.1.311", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.311", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0000049 tRNA binding;GO:0016407 acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0048789 cytoskeletal matrix organization at active zone;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006417 regulation of translation;GO:0007626 locomotory behavior;GO:0050808 synapse organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VQZ6-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VR52-1", "uniprot_id": [ { "id": "TILB_DROME", "url": "https://www.uniprot.org/uniprot/Q9VR52", "type": "external" } ], "mass": 45608.0, "length": 395, "protein_name": "Protein tilB", "gene_name": "tilB", "organism": "Fruit fly", "refseq_name": "touch insensitive larva B", "refseq_ac": [ { "id": "NP_608460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608460", "type": "external" } ], "gene_names_uniprotkb": "tilB; CG14620", "gene_names_refseq": "CG14620; Dmel\\CG14620; TilB; tilB", "protein_names_uniprotkb": "Protein tilB; Touch insensitive larva B protein", "protein_names_refseq": "CG14620-PA; TilB; tilB-PA; touch insensitive larva B; touch insensitive larvaeB; touch-insensitive-larva-B", "tax_id": 7227, "disease": "primary ciliary dyskinesia 19 (Disease Ontology:DOID:0110608)", "pathway": " (dme:Dmel_CG14620)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;20215474", "class_list": "", "function": "Cilium-specific protein required for cilia structures in Johnston's sensory organ. Plays a role in motility of cilia and flagella., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0031514 motile cilium", "go_biological_process": "GO:0007605 sensory perception of sound;GO:0036158 outer dynein arm assembly;GO:0035082 axoneme assembly;GO:0060285 cilium-dependent cell motility;GO:0010378 temperature compensation of the circadian clock", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VR52-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VR53-1", "uniprot_id": [ { "id": "Q9VR53_DROME", "url": "https://www.uniprot.org/uniprot/Q9VR53", "type": "external" } ], "mass": 38528.0, "length": 343, "protein_name": "DDB1- and CUL4-associated factor 7", "gene_name": "wap", "organism": "Fruit fly", "refseq_name": "wings apart, isoform C", "refseq_ac": [ { "id": "NP_001245797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245797", "type": "external" } ], "gene_names_uniprotkb": "wap; 15; 16; 19; 20; 21; 22; BcDNA:GM08142; CG14614; Dmel\\CG14614; Dmel_CG14614; Q217; Q464; Riq; WAP; l(1)20Ab; l(1)A-200; l(1)HM33; l(1)Q217; l(1)Q464; riq", "gene_names_refseq": "15; 16; 19; 20; 21; 22; BcDNA:GM08142; CG14614; Dmel\\CG14614; Q217; Q464; Riq; WAP; l(1)20Ab; l(1)A-200; l(1)HM33; l(1)Q217; l(1)Q464; riq; wap", "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 7; WD repeat-containing protein 68; WD repeat-containing protein An11 homolog", "protein_names_refseq": "CG14614-PC; riquiqui; section 15; section 16; section 19; section 20; section 21; section 22; wap-PC; wings apart, isoform C; wings apart; wings-apart", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14614); (R-DME-8951664)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007517 muscle organ development;GO:0045747 positive regulation of Notch signaling pathway;GO:0035331 negative regulation of hippo signaling;GO:0046622 positive regulation of organ growth;GO:0048627 myoblast development", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VR53-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VRH6-1", "uniprot_id": [ { "id": "GUF1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VRH6", "type": "external" } ], "mass": 77919.0, "length": 696, "protein_name": "Translation factor waclaw, mitochondrial", "gene_name": "waw", "organism": "Fruit fly", "refseq_name": "waclaw", "refseq_ac": [ { "id": "NP_001027089", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027089", "type": "external" } ], "gene_names_uniprotkb": "waw; CG1410", "gene_names_refseq": "CG1410; CG32527; Dmel\\CG1410; anon-19Fb; tu2; waw", "protein_names_uniprotkb": "Translation factor waclaw, mitochondrial; 3.6.5.-; EF-4; Elongation factor 4 homolog; GTPase GUF1 homolog; Ribosomal back-translocase", "protein_names_refseq": "CG1410-PA; waclaw; waw-PA", "tax_id": 7227, "disease": "West syndrome (Disease Ontology:DOID:0050562); developmental and epileptic encephalopathy 40 (Disease Ontology:DOID:0080427)", "pathway": " (dme:Dmel_CG1410)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;9520435", "class_list": "", "function": "Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O61347", "ec_number_list": [ { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0097177 mitochondrial ribosome binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006412 translation;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VRH6-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VRI9-1", "uniprot_id": [ { "id": "CP6T1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VRI9", "type": "external" } ], "mass": 60519.0, "length": 529, "protein_name": "Probable cytochrome P450 6t1", "gene_name": "Cyp6t1", "organism": "Fruit fly", "refseq_name": "cytochrome P450 6t1", "refseq_ac": [ { "id": "NP_608457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608457", "type": "external" } ], "gene_names_uniprotkb": "Cyp6t1; CG1644", "gene_names_refseq": "6t1; CG1644; Cyp6T1; Cyp6t1; Dmel\\CG1644", "protein_names_uniprotkb": "Probable cytochrome P450 6t1; 1.14.-.-; CYPVIT1", "protein_names_refseq": "CG1644-PA; Cyp6t1-PA; cytochrome P450 6t1; cytochrome P450", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1644)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046680 response to DDT;GO:0046701 insecticide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VRI9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VRL2-1", "uniprot_id": [ { "id": "GOSR2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VRL2", "type": "external" } ], "mass": 24833.0, "length": 216, "protein_name": "Probable Golgi SNAP receptor complex member 2", "gene_name": "Membrin", "organism": "Fruit fly", "refseq_name": "membrin", "refseq_ac": [ { "id": "NP_647960", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647960", "type": "external" } ], "gene_names_uniprotkb": "Membrin; CG4780", "gene_names_refseq": "BcDNA:SD22572; CG4780; Dmel\\CG4780; Membrin; Memb; SNARE/membrin; membrin", "protein_names_uniprotkb": "Probable Golgi SNAP receptor complex member 2", "protein_names_refseq": "CG4780-PA; Membrin-PA; fmembrin; membrin; moon cheese", "tax_id": 7227, "disease": "progressive myoclonus epilepsy 6 (Disease Ontology:DOID:0111449); progressive myoclonus epilepsy (Disease Ontology:DOID:891)", "pathway": " (dme:Dmel_CG4780); (R-DME-204005); (R-DME-5694530); (R-DME-6807878); (R-DME-6811438)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "10731132;10908590;12537569;12537572", "class_list": "", "function": "Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5RJH1;Q8MRU9", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0031902 late endosome membrane;GO:0012507 ER to Golgi transport vesicle membrane", "go_biological_process": "GO:0015031 protein transport;GO:0016192 vesicle-mediated transport;GO:0006906 vesicle fusion;GO:0035149 lumen formation, open tracheal system", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VRL2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VRL3-1", "uniprot_id": [ { "id": "PFD4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VRL3", "type": "external" } ], "mass": 15936.0, "length": 138, "protein_name": "Probable prefoldin subunit 4", "gene_name": "Pfdn4", "organism": "Fruit fly", "refseq_name": "prefoldin 4", "refseq_ac": [ { "id": "NP_647961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647961", "type": "external" } ], "gene_names_uniprotkb": "Pfdn4; CG10635", "gene_names_refseq": "BcDNA:SD11994; CG10635; Dmel\\CG10635; Pfdn4; pfdn4", "protein_names_uniprotkb": "Probable prefoldin subunit 4", "protein_names_refseq": "CG10635-PA; Pfdn4-PA; prefoldin 4", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10635)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016272 prefoldin complex", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VRL3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VRN5-1", "uniprot_id": [ { "id": "LIN28_DROME", "url": "https://www.uniprot.org/uniprot/Q9VRN5", "type": "external" } ], "mass": 21594.0, "length": 195, "protein_name": "Protein lin-28 homolog", "gene_name": "lin-28", "organism": "Fruit fly", "refseq_name": "lin-28", "refseq_ac": [ { "id": "NP_647983", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647983", "type": "external" } ], "gene_names_uniprotkb": "lin-28; CG17334", "gene_names_refseq": "BcDNA:RE05342; CG17334; Dmel\\CG17334; EP(3)0915; LIN-28; LIN28B; Lin-28; Lin28; lin-28; lin28", "protein_names_uniprotkb": "Protein lin-28 homolog", "protein_names_refseq": "CG17334-PA; Lin28; lin-28-PA; lin-28", "tax_id": 7227, "disease": "nephroblastoma (Disease Ontology:DOID:2154); neuroblastoma (Disease Ontology:DOID:769)", "pathway": " (dme:Dmel_CG17334)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;12798299", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0003730 mRNA 3'-UTR binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0048621 post-embryonic digestive tract morphogenesis;GO:2000648 positive regulation of stem cell proliferation;GO:0010608 post-transcriptional regulation of gene expression;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0031054 pre-miRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VRN5-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VRP8-1", "uniprot_id": [ { "id": "Q9VRP8_DROME", "url": "https://www.uniprot.org/uniprot/Q9VRP8", "type": "external" } ], "mass": 37333.0, "length": 324, "protein_name": "Cellular retinaldehyde binding protein", "gene_name": "Cralbp", "organism": "Fruit fly", "refseq_name": "cellular retinaldehyde binding protein", "refseq_ac": [ { "id": "NP_523939", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523939", "type": "external" } ], "gene_names_uniprotkb": "Cralbp; CG10546; CRALBP; Dmel\\CG10546; Dmel_CG10546", "gene_names_refseq": "CG10546; CRALBP; Cralbp; Dmel\\CG10546", "protein_names_uniprotkb": "Cellular retinaldehyde binding protein", "protein_names_refseq": "CG10546-PA; Cralbp-PA; cellular retinaldehyde binding protein", "tax_id": 7227, "disease": "Bothnia retinal dystrophy (Disease Ontology:DOID:0050683); Newfoundland cone-rod dystrophy (Disease Ontology:DOID:0111015); retinitis pigmentosa (Disease Ontology:DOID:10584); fundus albipunctatus (Disease Ontology:DOID:11105); night blindness (Disease Ontology:DOID:8499)", "pathway": " (dme:Dmel_CG10546); (R-DME-2187335); (R-DME-2453902); (R-DME-432720)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 5, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1902936 phosphatidylinositol bisphosphate binding;GO:0016918 retinal binding", "go_cellular_component": "GO:0005768 endosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VRP8-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VRS5-1", "uniprot_id": [ { "id": "Q9VRS5_DROME", "url": "https://www.uniprot.org/uniprot/Q9VRS5", "type": "external" } ], "mass": 35501.0, "length": 319, "protein_name": "Peptidase S1 domain-containing protein", "gene_name": "SP127", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_648011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648011", "type": "external" } ], "gene_names_uniprotkb": "SP127; CG6462; Dmel\\CG6462; Dmel_CG6462", "gene_names_refseq": "CG6462; Dmel\\CG6462; SP127", "protein_names_uniprotkb": "Peptidase S1 domain-containing protein", "protein_names_refseq": "CG6462-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6462); (R-DME-1474228)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VRS5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VRT5-1", "uniprot_id": [ { "id": "Q9VRT5_DROME", "url": "https://www.uniprot.org/uniprot/Q9VRT5", "type": "external" } ], "mass": 49202.0, "length": 436, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG6602", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_648020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648020", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG6602; CG6602; Dmel_CG6602", "gene_names_refseq": "CG6602; Dmel\\CG6602", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG6602-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6602)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;33925313", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VRT5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VRX2-1", "uniprot_id": [ { "id": "VPS8_DROME", "url": "https://www.uniprot.org/uniprot/Q9VRX2", "type": "external" } ], "mass": 137922.0, "length": 1229, "protein_name": "Vacuolar protein sorting-associated protein 8 homolog", "gene_name": "Vps8", "organism": "Fruit fly", "refseq_name": "vacuolar protein sorting 8", "refseq_ac": [ { "id": "NP_648048", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648048", "type": "external" } ], "gene_names_uniprotkb": "Vps8; CG10144", "gene_names_refseq": "CG10144; Dmel\\CG10144; Vps8; anon-WO0118547.365; vps8", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 8 homolog; Vacuolar protein sorting 8", "protein_names_refseq": "CG10144-PA; Vps8-PA; vacuolar protein sorting 8", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10144)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;27253064;31194677", "class_list": "", "function": "Part of the class C core vacuole/endosome tethering (CORVET) complex involved in endo-lysosomal vesicle trafficking and lysosome biogenesis by facilitating docking and fusion of endosomal vesicles (PubMed:27253064, PubMed:31194677). The CORVET complex acts upstream of the homotypic fusion and vacuole protein sorting (HOPS) tethering complex but is not involved in autophagic flux (PubMed:27253064, PubMed:31194677). The CORVET complex may cooperate with the early endosomal tether Rbsn-5 to mediate endosomal fusion (PubMed:27253064). As part of the CORVET complex recruited to endosomes by activated GTP-bound Rab5 (PubMed:27253064). Specifically required for endocytic trafficking in a subset of cells, such as hemocytes and nephrocytes, which are highly active in endocytosis (PubMed:27253064)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B7FNP6;C5WLL9;D0IQG0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0051020 GTPase binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005770 late endosome;GO:0033263 CORVET complex", "go_biological_process": "GO:0035542 regulation of SNARE complex assembly;GO:0006897 endocytosis;GO:0007032 endosome organization;GO:0016197 endosomal transport;GO:0034058 endosomal vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VRX2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VRX3-1", "uniprot_id": [ { "id": "TBBP_DROME", "url": "https://www.uniprot.org/uniprot/Q9VRX3", "type": "external" } ], "mass": 50729.0, "length": 462, "protein_name": "beta-Tubulin at 65B", "gene_name": "betaTub65B", "organism": "Fruit fly", "refseq_name": "beta-Tubulin at 65B", "refseq_ac": [ { "id": "NP_729172", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_729172", "type": "external" } ], "gene_names_uniprotkb": "betaTub65B; CG32396", "gene_names_refseq": "CG32396; CG8339; CT42364; Dmel\\CG32396; Tub2B; Tubb4b; betaTub65B", "protein_names_uniprotkb": "beta-Tubulin at 65B", "protein_names_refseq": "CG32396-PA; beta-Tubulin at 65B; betaTub65B-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG32396); (R-DME-3371497); (R-DME-6798695); (R-DME-6807878); (R-DME-6811436)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VRX3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VS19-1", "uniprot_id": [ { "id": "Q9VS19_DROME", "url": "https://www.uniprot.org/uniprot/Q9VS19", "type": "external" } ], "mass": 66390.0, "length": 605, "protein_name": "Bardet-Biedl syndrome 1", "gene_name": "BBS1", "organism": "Fruit fly", "refseq_name": "Bardet-Biedl syndrome 1", "refseq_ac": [ { "id": "NP_648080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648080", "type": "external" } ], "gene_names_uniprotkb": "BBS1; CG14825; Dmel\\CG14825; Dmel_CG14825", "gene_names_refseq": "BBS1; CG14825; Dmel\\CG14825", "protein_names_uniprotkb": "Bardet-Biedl syndrome 1", "protein_names_refseq": "BBS1-PA; Bardet-Biedl syndrome 1 ortholog; Bardet-Biedl syndrome 1; CG14825-PA", "tax_id": 7227, "disease": "Bardet-Biedl syndrome 1 (Disease Ontology:DOID:0110123); Bardet-Biedl syndrome (Disease Ontology:DOID:1935); obesity (Disease Ontology:DOID:9970)", "pathway": " (dme:Dmel_CG14825); (R-DME-5620922)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005113 patched binding;GO:0005119 smoothened binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0005930 axoneme;GO:0034464 BBSome", "go_biological_process": "GO:0060271 cilium assembly;GO:1905515 non-motile cilium assembly;GO:0061512 protein localization to cilium", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VS19-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VS46-1", "uniprot_id": [ { "id": "RINT1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VS46", "type": "external" } ], "mass": 83535.0, "length": 724, "protein_name": "RINT1-like protein", "gene_name": "Rint1", "organism": "Fruit fly", "refseq_name": "RAD50 interactor 1", "refseq_ac": [ { "id": "NP_648102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648102", "type": "external" } ], "gene_names_uniprotkb": "Rint1; CG8605", "gene_names_refseq": "CG8605; Dmel\\CG8605; Rint-1; Rint1; Tip20; rint1", "protein_names_uniprotkb": "RINT1-like protein; DmRINT-1", "protein_names_refseq": "CG8605-PA; RAD50 interactor 1; RINT1 ortholog; Rint1-PA", "tax_id": 7227, "disease": "infantile liver failure syndrome (Disease Ontology:DOID:0080716)", "pathway": " (dme:Dmel_CG8605); (R-DME-6811434)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;22685323", "class_list": "", "function": "During cytokinesis in male meiotic cells, required for completion of cleavage furrow ingression possibly in conjunction with Zw10. Required for maintenance of Golgi stack number and morphology. Essential for acroblast assembly., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q961W7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0070939 Dsl1/NZR complex;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0036090 cleavage furrow ingression;GO:0007030 Golgi organization;GO:0048193 Golgi vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VS46-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VS51-1", "uniprot_id": [ { "id": "Q9VS51_DROME", "url": "https://www.uniprot.org/uniprot/Q9VS51", "type": "external" } ], "mass": 61031.0, "length": 546, "protein_name": "Cln7, isoform A; Cln7, isoform B; Cln7, isoform C", "gene_name": "Cln7", "organism": "Fruit fly", "refseq_name": "Cln7, isoform B", "refseq_ac": [ { "id": "NP_001261508", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261508", "type": "external" } ], "gene_names_uniprotkb": "Cln7; CG8596; CLN7; Dmel\\CG8596; Dmel_CG8596; cln7", "gene_names_refseq": "CG8596; CLN7; Cln7; Dmel\\CG8596; cln7", "protein_names_uniprotkb": "Cln7, isoform A; Cln7, isoform B; Cln7, isoform C", "protein_names_refseq": "CG8596-PB; Cln7, isoform B; Cln7-PB", "tax_id": 7227, "disease": "neuronal ceroid lipofuscinosis 7 (Disease Ontology:DOID:0110722)", "pathway": " (dme:Dmel_CG8596)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8T0M3", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0012505 endomembrane system;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VS51-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VS77-1", "uniprot_id": [ { "id": "MTH6_DROME", "url": "https://www.uniprot.org/uniprot/Q9VS77", "type": "external" } ], "mass": 56079.0, "length": 480, "protein_name": "Probable G protein-coupled receptor Mth-like 6", "gene_name": "mthl6", "organism": "Fruit fly", "refseq_name": "methuselah-like 6", "refseq_ac": [ { "id": "NP_788473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788473", "type": "external" } ], "gene_names_uniprotkb": "mthl6; CG16992", "gene_names_refseq": "CG16992; Dmel\\CG16992; Mthl6; anon-WO0170980.127; anon-WO0170980.128; mth16; mthl6", "protein_names_uniprotkb": "Probable G protein-coupled receptor Mth-like 6; Protein methuselah-like 6", "protein_names_refseq": "CG16992-PA; methuselah-like 6; mth-like 6; mthl6-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG16992)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;10908591;12537572", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0042594 response to starvation;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VS77-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VSA4-1", "uniprot_id": [ { "id": "TONSL_DROME", "url": "https://www.uniprot.org/uniprot/Q9VSA4", "type": "external" } ], "mass": 158302.0, "length": 1405, "protein_name": "Tonsoku-like protein", "gene_name": "CG7457", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001303376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303376", "type": "external" } ], "gene_names_uniprotkb": "CG7457", "gene_names_refseq": "CG7457; CT13960; Dmel\\CG7457", "protein_names_uniprotkb": "Tonsoku-like protein", "protein_names_refseq": "CG7457-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "spondyloepimetaphyseal dysplasia, Sponastrime type (Disease Ontology:DOID:5684)", "pathway": " (dme:Dmel_CG7457)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18327897", "class_list": "", "function": "Histone reader involved in homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks. Specifically recognizes and binds histone H3.1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, 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fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_648151", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648151", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG8492; CG8492; Dmel_CG8492", "gene_names_refseq": "CG8492; Dmel\\CG8492", "protein_names_uniprotkb": "lysozyme; 3.2.1.17", "protein_names_refseq": "CG8492-PD; uncharacterized protein", "tax_id": 7227, "disease": "gastroenteritis (Disease Ontology:DOID:2326); viral infectious disease (Disease Ontology:DOID:934)", "pathway": " (dme:Dmel_CG8492); (R-DME-6798695); (R-DME-6803157)", "pathway_count": 3, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357;40245499", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, 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"type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.5.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.28", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "4.6.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.19", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.4.17.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.13", "type": "external" }, { "id": "1.11.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.2.-", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" } ], "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VSA5-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VSE7-2", "uniprot_id": [ { "id": "MTH7_DROME", "url": "https://www.uniprot.org/uniprot/Q9VSE7", "type": "external" } ], "mass": 57383.0, "length": 491, "protein_name": "Probable G protein-coupled receptor Mth-like 7", "gene_name": "mthl7", "organism": "Fruit fly", "refseq_name": "methuselah-like 7, isoform A", "refseq_ac": [ { "id": "NP_648181", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648181", "type": "external" } ], "gene_names_uniprotkb": "mthl7; CG7476", "gene_names_refseq": "CG7476; Dmel\\CG7476; Mthl7; anon-WO0170980.85; anon-WO0170980.86; mthl7", "protein_names_uniprotkb": "Probable G protein-coupled receptor Mth-like 7; Protein methuselah-like 7", "protein_names_refseq": "CG7476-PA; Mth-like 7; methuselah-like 7, isoform A; mthl7-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7476)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;10908591;12537572", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0042594 response to starvation;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VSE7-2", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VSK8-1", "uniprot_id": [ { "id": "ZC3H3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VSK8", "type": "external" } ], "mass": 66322.0, "length": 597, "protein_name": "Zinc finger CCCH domain-containing protein 3", "gene_name": "ZC3H3", "organism": "Fruit fly", "refseq_name": "ZC3H3", "refseq_ac": [ { "id": "NP_648230", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648230", "type": "external" } ], "gene_names_uniprotkb": "ZC3H3; CG6694", "gene_names_refseq": "CG6694; Dmel\\CG6694; ZC3H3; dZC3H3", "protein_names_uniprotkb": "Zinc finger CCCH domain-containing protein 3; dZC3H3", "protein_names_refseq": "CG6694-PA; ZC3H3-PA; ZC3H3", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6694); (R-DME-9930044)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537572;19364924", "class_list": "", "function": "Required for the export of polyadenylated mRNAs from the nucleu; binds to polyadenylated mRNA, and is involved in the regulation of mRNA polyadenylation., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0051168 nuclear export;GO:0010793 regulation of mRNA export from nucleus;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VSK8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VSU7-1", "uniprot_id": [ { "id": "USE1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VSU7", "type": "external" } ], "mass": 28286.0, "length": 250, "protein_name": "Vesicle transport protein USE1", "gene_name": "Use1", "organism": "Fruit fly", "refseq_name": "unconventional SNARE in the ER 1", "refseq_ac": [ { "id": "NP_648289", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648289", "type": "external" } ], "gene_names_uniprotkb": "Use1; CG14181", "gene_names_refseq": "CG14181; Dmel\\CG14181; FBgn 35965; Use1", "protein_names_uniprotkb": "Vesicle transport protein USE1; USE1-like protein", "protein_names_refseq": "CG14181-PA; USE1 ortholog; Use1-PA; unconventional SNARE in the ER 1", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14181); (R-DME-6811434)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537572;16452979", "class_list": "", "function": "SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER (By similarity). Required for protein secretion., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NN76", "ec_number_list": [], "go_molecular_function": "GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum;GO:0012505 endomembrane system;GO:0031201 SNARE complex", "go_biological_process": "GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0009306 protein secretion;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VSU7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VT08-1", "uniprot_id": [ { "id": "OR67A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VT08", "type": "external" } ], "mass": 47046.0, "length": 407, "protein_name": "Odorant receptor 67a", "gene_name": "Or67a", "organism": "Fruit fly", "refseq_name": "odorant receptor 67a", "refseq_ac": [ { "id": "NP_524005", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524005", "type": "external" } ], "gene_names_uniprotkb": "Or67a; CG12526", "gene_names_refseq": "67B.1; 67a; CG12526; DOR84; DmOR67a; DmOr67a; DmelOr67a.P; Dmel\\CG12526; OR67a; Or67a", "protein_names_uniprotkb": "Odorant receptor 67a", "protein_names_refseq": "CG12526-PA; Or67a-PA; odorant receptor 67a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12526)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;10943836;12537572;16615896;20628035;21677030", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. Forms a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to benzaldehyde and acetophenone., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B3DMT0", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VT08-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VT50-1", "uniprot_id": [ { "id": "INSL1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VT50", "type": "external" } ], "mass": 16851.0, "length": 154, "protein_name": "Insulin-like peptide 1", "gene_name": "Ilp1", "organism": "Fruit fly", "refseq_name": "Insulin-like peptide 1", "refseq_ac": [ { "id": "NP_648359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648359", "type": "external" } ], "gene_names_uniprotkb": "Ilp1; CG14173", "gene_names_refseq": "CG14173; DILP 1; DILP-1; DILP1; DILPs; DILP; Dilp 1; Dilp-1; Dilp1-5; Dilp1; Dilp; Dmel\\CG14173; ILP1; ILPs; Ilp-1; Ilp1; Ilp; dILP1; dILP; dilp-1; dilp1; dilp; dlp; ilp1", "protein_names_uniprotkb": "Insulin-like peptide 1; Insulin-related peptide 1; dILP1", "protein_names_refseq": "CG14173-PA; Ilp1-PA; Insulin-like peptide 1; drosophila insulin-like peptide 1; drosophila insulin-like peptide; insulin/insulin-like growth factor", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14173); (R-DME-110478)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10455177;10731132;10801879;11250149;11752451;11872800;12537572;12893776;7628438;8978685;9169420;9368760", "class_list": "", "function": "Possible ligand of InR/insulin-like receptor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0008286 insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VT50-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VT51-1", "uniprot_id": [ { "id": "INSL2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VT51", "type": "external" } ], "mass": 15255.0, "length": 137, "protein_name": "Insulin-like peptide 2", "gene_name": "Ilp2", "organism": "Fruit fly", "refseq_name": "Insulin-like peptide 2", "refseq_ac": [ { "id": "NP_524012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524012", "type": "external" } ], "gene_names_uniprotkb": "Ilp2; CG8167; IRP", "gene_names_refseq": "Akh; CG8167; DILP 2; DILP-2; DILP2; DILPs; DILP; Dilp 2; Dilp-2; Dilp1-5; Dilp2; Dilp; Dmel\\CG8167; ILP-2; ILP2; ILPs; IRP; IlP2; Ilp-2; Ilp2; Ilp; dILP-2; dILP2; dIlp2; dilp 2; dilp-2; dilp2; dilp; dipl2; dlp; ilp2; llp2", "protein_names_uniprotkb": "Insulin-like peptide 2; Insulin-related peptide 2; dILP2", "protein_names_refseq": "CG8167-PA; Dilp2; Ilp2-PA; Insulin- related peptide 2; Insulin-like peptide 2; Insulin-like peptide; Insulin-related peptide; drosophila insulin like peptide 2; drosophila insulin-like peptide 2; drosophila insulin-like receptor; insulin-like 2; insulin-like peptide-2; insulin/insulin-like growth factor", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8167); (R-DME-110478)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "10455177;10731132;10801879;11179818;11250149;11752451;11872800;12537569;12537572;12893776;7628438;8978685;9169420;9368760", "class_list": "", "function": "Plays a role in regulating body size by increasing cell size and cell number of individual organs. Probably mediates its growth effects by acting as a ligand for the insulin receptor and transducing a signal via the Chico/PI3K/Akt(PKB) pathway., [UniProtKB, PubMed]; Possible ligand of InR/insulin-like receptor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0005179 hormone activity;GO:0008083 growth factor activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0060180 female mating behavior;GO:0033500 carbohydrate homeostasis;GO:0045818 negative regulation of glycogen catabolic process;GO:2000252 negative regulation of feeding behavior;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "Q9VT51-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VT52-1", "uniprot_id": [ { "id": "INSL3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VT52", "type": "external" } ], "mass": 13708.0, "length": 120, "protein_name": "Insulin-like peptide 3", "gene_name": "Ilp3", "organism": "Fruit fly", "refseq_name": "Insulin-like peptide 3", "refseq_ac": [ { "id": "NP_648360", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648360", "type": "external" } ], "gene_names_uniprotkb": "Ilp3; CG14167", "gene_names_refseq": "CG14167; DILP 3; DILP-3; DILP3; DILPs; DILP; Dilp 3; Dilp-3; Dilp1-5; Dilp3; Dilp; Dmel\\CG14167; ILP3; ILPs; IlP3; Ilp-3; Ilp3; Ilp; dILP-3; dILP3; dILp3; dIlp3; dilp 3; dilp-3; dilp3; dilp; dipl3; dlp3; dlp; ilp3", "protein_names_uniprotkb": "Insulin-like peptide 3; Insulin-related peptide 3; dILP3", "protein_names_refseq": "CG14167-PA; Ilp3-PA; Insulin-like peptide 3; Insulin-like peptide; drosophila insulin-like peptide 3; insulin/insulin-like growth factor", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14167); (R-DME-110478)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "10455177;10731132;10801879;11250149;11752451;11872800;12537572;12893776;7628438;8978685;9169420;9368760", "class_list": "", "function": "Possible ligand of InR/insulin-like receptor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0060180 female mating behavior;GO:0030431 sleep;GO:0008286 insulin receptor signaling pathway;GO:0009743 response to carbohydrate;GO:0045475 locomotor rhythm", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VT52-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VT53-1", "uniprot_id": [ { "id": "INSL4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VT53", "type": "external" } ], "mass": 15140.0, "length": 134, "protein_name": "Insulin-like peptide 4", "gene_name": "Ilp4", "organism": "Fruit fly", "refseq_name": "Insulin-like peptide 4", "refseq_ac": [ { "id": "NP_648361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648361", "type": "external" } ], "gene_names_uniprotkb": "Ilp4; CG6736", "gene_names_refseq": "A; BcDNA:RE27042; CG6736; DILP 4; DILP-4; DILP4; DILPs; DILP; Dilp 4; Dilp1-5; Dilp4; Dilp; Dirlp; Dmel\\CG6736; ILP4; ILPs; Ilp-4; Ilp4; Ilp; Mes3; anon-EST:CLB3; dILP4; dIlp4; dilp-4; dilp4; dilp; dlp; ilp4; mes3", "protein_names_uniprotkb": "Insulin-like peptide 4; Insulin-related peptide 4; dILP4", "protein_names_refseq": "CG6736-PA; Ilp4-PA; Insulin-like peptide 4; drosophila insulin-like peptide 4; drosophila insulin/relaxin-like peptide; insulin-like peptide-4; insulin/insulin-like growth factor", "tax_id": 7227, "disease": "cryptorchidism (Disease Ontology:DOID:11383)", "pathway": " (dme:Dmel_CG6736); (R-DME-110478); (R-DME-444821)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10455177;10731132;10801879;11250149;11752451;11872800;12537569;12537572;12893776;7628438;8978685;9169420;9368760", "class_list": "", "function": "Possible ligand of InR/insulin-like receptor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0008286 insulin receptor signaling pathway;GO:0030536 larval feeding behavior", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9VT53-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VT92-1", "uniprot_id": [ { "id": "OR67D_DROME", "url": "https://www.uniprot.org/uniprot/Q9VT92", "type": "external" } ], "mass": 44475.0, "length": 391, "protein_name": "Odorant receptor 67d", "gene_name": "Or67d", "organism": "Fruit fly", "refseq_name": "odorant receptor 67d", "refseq_ac": [ { "id": "NP_648390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648390", "type": "external" } ], "gene_names_uniprotkb": "Or67d; CG14157", "gene_names_refseq": "67d; CG14157; DmOr67d; DmelOr67d; Dmel\\CG14157; OR67d; Or67d; or67d", "protein_names_uniprotkb": "Odorant receptor 67d", "protein_names_refseq": "CG14157-PA; Or67d-PA; odorant receptor 67d; olfactory receptor 67d", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14157)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10731132;12537572;16928861;17363250;17392786;17943085;18305480;19966787", "class_list": "", "function": "Odorant receptor for the fatty-acid-derived male pheromone 11-cis vaccenyl acetate (cVA). Acts in concert with Snmp and lush to capture cVA molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. Necessary to mediate behavioral responses to cVA by regulating both male and female mating behavior. Activation of Or67d neurons by cVA inhibits courtship of other males, whereas in females their activation promotes receptivity to other males., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032590 dendrite membrane;GO:0071683 sensory dendrite", "go_biological_process": "GO:0007165 signal transduction;GO:0007608 sensory perception of smell;GO:0019236 response to pheromone;GO:0050911 detection of chemical stimulus involved in sensory perception of smell;GO:0007619 courtship behavior", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VT92-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VTH0-1", "uniprot_id": [ { "id": "PLOD_DROME", "url": "https://www.uniprot.org/uniprot/Q9VTH0", "type": "external" } ], "mass": 82510.0, "length": 721, "protein_name": "Procollagen-lysine,2-oxoglutarate 5-dioxygenase", "gene_name": "Plod", "organism": "Fruit fly", "refseq_name": "procollagen lysyl hydroxylase, isoform A", "refseq_ac": [ { "id": "NP_648451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648451", "type": "external" } ], "gene_names_uniprotkb": "Plod; CG6199", "gene_names_refseq": "CG6199; Dmel\\CG6199; LH3; Plod; RE-H; anon-EST:ParkEST325; anon-WO0118547.416; dPlod; dplod; plod", "protein_names_uniprotkb": "Procollagen-lysine,2-oxoglutarate 5-dioxygenase; 1.14.11.4; Procollagen lysyl hydroxylase", "protein_names_refseq": "CG6199-PA; Plod-PA; drosophila plod; lysyl hydroxylase; procollagen lysyl hydroxylase, isoform A", "tax_id": 7227, "disease": "Bruck syndrome (Disease Ontology:DOID:0060231); BCARD syndrome (Disease Ontology:DOID:0061197); Ehlers-Danlos syndrome kyphoscoliotic type 1 (Disease Ontology:DOID:0080734); Ehlers-Danlos syndrome (Disease Ontology:DOID:13359); hypothyroidism (Disease Ontology:DOID:1459); lung adenocarcinoma (Disease Ontology:DOID:3910); hepatocellular carcinoma (Disease Ontology:DOID:684)", "pathway": " (dme:Dmel_CG6199); (R-DME-1650814)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;20888931;23369713;33925313", "class_list": "", "function": "Forms hydroxylysine residues in collagen type IV (By similarity). Required for the secretion of collagen type IV (vkg) from haemocytes, fat body and follicle cells (PubMed:20888931, PubMed:23369713)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 7, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q86NR6;Q8MSV4", "ec_number_list": [ { "id": "1.14.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.4", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0008475 procollagen-lysine 5-dioxygenase activity;GO:0050211 procollagen galactosyltransferase activity;GO:0033823 procollagen glucosyltransferase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0031012 extracellular matrix;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0030199 collagen fibril organization;GO:0180062 protein O-linked glycosylation via galactose", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VTH0-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VTK2-1", "uniprot_id": [ { "id": "POMT1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VTK2", "type": "external" } ], "mass": 101194.0, "length": 886, "protein_name": "Protein O-mannosyltransferase 1", "gene_name": "rt", "organism": "Fruit fly", "refseq_name": "rotated abdomen", "refseq_ac": [ { "id": "NP_524025", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524025", "type": "external" } ], "gene_names_uniprotkb": "rt; CG6097; POMT1", "gene_names_refseq": "CG6097; DPOMT1; Dmel\\CG6097; POMT-1; POMT1; Rot_abd; Rt; dPOMT1; dPomt1; fs(3)neo1; pomt; roa; rt", "protein_names_uniprotkb": "Protein O-mannosyltransferase 1; 2.4.1.109; Dolichyl-phosphate-mannose--protein mannosyltransferase 1; Protein rotated abdomen; dPOMT1", "protein_names_refseq": "CG6097-PA; drosophila protein O-mannosyltransferase 1; rotated abdomen; rt-PA", "tax_id": 7227, "disease": "lissencephaly (Disease Ontology:DOID:0050453); Walker-Warburg syndrome (Disease Ontology:DOID:0050560); muscular dystrophy-dystroglycanopathy type B1 (Disease Ontology:DOID:0050588); cardiomyopathy (Disease Ontology:DOID:0050700); autosomal recessive limb-girdle muscular dystrophy type 2K (Disease Ontology:DOID:0110297); congenital muscular dystrophy-dystroglycanopathy type A1 (Disease Ontology:DOID:0111237); muscular dystrophy-dystroglycanopathy (Disease Ontology:DOID:0112374); cleft lip (Disease Ontology:DOID:9296); muscular dystrophy (Disease Ontology:DOID:9884)", "pathway": " (dme:Dmel_CG6097); (R-DME-8932504); (R-DME-8932505); (R-DME-8932506)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;15271988;16219785;8650217", "class_list": "glycogene;glycosyltransferase", "function": "Rt/POMT1 and tw/POMT2 function as a protein O-mannosyltransferase in association with each other to generate and maintain normal muscle development., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 9, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q60GL9;Q8SYW7;Q94891", "ec_number_list": [ { "id": "2.4.1.109", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.109", "type": "external" } ], "go_molecular_function": "GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex", "go_biological_process": "GO:0007525 somatic muscle development;GO:0007517 muscle organ development;GO:0045214 sarcomere organization;GO:0035269 protein O-linked glycosylation via mannose;GO:0060025 regulation of synaptic activity", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VTK2-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000011000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VTN0-1", "uniprot_id": [ { "id": "GR68A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VTN0", "type": "external" } ], "mass": 43780.0, "length": 389, "protein_name": "Gustatory receptor 68a", "gene_name": "Gr68a", "organism": "Fruit fly", "refseq_name": "gustatory receptor 68a", "refseq_ac": [ { "id": "NP_524027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524027", "type": "external" } ], "gene_names_uniprotkb": "Gr68a; CG7303; GR68D.1", "gene_names_refseq": "68D.1; CG7303; Dmel\\CG7303; GR68D.1; GR68a; Gr68D1; Gr68a", "protein_names_uniprotkb": "Gustatory receptor 68a", "protein_names_refseq": "CG7303-PA; Gr68a-PA; gustatory receptor 68D.1; gustatory receptor 68a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7303)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;11516643;12537572;12971900;22031876;26083710", "class_list": "", "function": "Dsx-dependent essential component of pheromone-driven courtship behavior (PubMed:12971900). Recognizes a female pheromone involved in the second step (tapping step) of the courtship display which is essential for efficient execution of the entire courtship sequence and timely mating (PubMed:12971900). Required for detection of the male sex pheromone CH503 which is transferred from males to females during mating and inhibits courtship behavior by other males (PubMed:26083710). Gr68a-expressing neurons in the male foreleg relay signals to the suboesophageal zone (SEZ) and courtship suppression is mediated by the release of the neuropeptide tachykinin from a cluster of 8-10 neurons in the SEZ (PubMed:26083710)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0008527 taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0008049 male courtship behavior;GO:0007165 signal transduction;GO:0034220 monoatomic ion transmembrane transport;GO:0007635 chemosensory behavior;GO:0050909 sensory perception of taste", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VTN0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VTT6-1", "uniprot_id": [ { "id": "Q9VTT6_DROME", "url": "https://www.uniprot.org/uniprot/Q9VTT6", "type": "external" } ], "mass": 73277.0, "length": 635, "protein_name": "Ionotropic receptor 68b", "gene_name": "Ir68b", "organism": "Fruit fly", "refseq_name": "ionotropic receptor 68b", "refseq_ac": [ { "id": "NP_648548", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648548", "type": "external" } ], "gene_names_uniprotkb": "Ir68b; 68b; CG17152; CT38092; DmelIR68b; Dmel\\CG17152; Dmel_CG17152; IR68b", "gene_names_refseq": "68b; CG17152; CT38092; DmelIR68b; Dmel\\CG17152; IR68b; Ir68b", "protein_names_uniprotkb": "Ionotropic receptor 68b", "protein_names_refseq": "CG17152-PA; Ir68b-PA; ionotropic receptor 68b", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17152)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0009593 detection of chemical stimulus;GO:0050907 detection of chemical stimulus involved in sensory perception", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VTT6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VU08-1", "uniprot_id": [ { "id": "VP13D_DROME", "url": "https://www.uniprot.org/uniprot/Q9VU08", "type": "external" } ], "mass": 445040.0, "length": 3919, "protein_name": "Intermembrane lipid transfer protein Vps13D", "gene_name": "Vps13D", "organism": "Fruit fly", "refseq_name": "vacuolar protein sorting 13D", "refseq_ac": [ { "id": "NP_729825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_729825", "type": "external" } ], "gene_names_uniprotkb": "Vps13D; CG32113", "gene_names_refseq": "CG11002; CG11003; CG32113; Dmel\\CG32113; Vps13D", "protein_names_uniprotkb": "Intermembrane lipid transfer protein Vps13D; Vacuolar protein sorting-associated protein 13D", "protein_names_refseq": "CG32113-PB; Vps13D-PB; vacuolar protein sorting 13D", "tax_id": 7227, "disease": "autosomal recessive spinocerebellar ataxia 4 (Disease Ontology:DOID:0111611)", "pathway": " (dme:Dmel_CG32113)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537572;29307555;29604224;40245499", "class_list": "", "function": "Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis (PubMed:29307555)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 2, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 1, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0043130 ubiquitin binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0045053 protein retention in Golgi apparatus;GO:0006869 lipid transport;GO:0007005 mitochondrion organization;GO:0000423 mitophagy;GO:0061709 reticulophagy", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VU08-1", "record_type": "protein", "filter_code": "0000000.0100111.001000.000000100000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VU87-1", "uniprot_id": [ { "id": "VPS36_DROME", "url": "https://www.uniprot.org/uniprot/Q9VU87", "type": "external" } ], "mass": 44214.0, "length": 399, "protein_name": "Vacuolar protein-sorting-associated protein 36", "gene_name": "Vps36", "organism": "Fruit fly", "refseq_name": "vacuolar protein sorting 36", "refseq_ac": [ { "id": "NP_648660", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648660", "type": "external" } ], "gene_names_uniprotkb": "Vps36; CG10711", "gene_names_refseq": "CG10711; Dmel\\CG10711; Vps36; l(3)L5212; vps36", "protein_names_uniprotkb": "Vacuolar protein-sorting-associated protein 36; ESCRT-II complex subunit VPS36", "protein_names_refseq": "CG10711-PA; Vps36-PA; lethal (3) L5212; vacuolar protein sorting 36", "tax_id": 7227, "disease": "cancer (Disease Ontology:DOID:162)", "pathway": " (dme:Dmel_CG10711); (R-DME-917729)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;17268469;19132102;29307555", "class_list": "", "function": "Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs (PubMed:19132102). The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation (PubMed:19132102). The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex (By similarity). ESCRT-II interacts, through the Vps36 subunit, with bicoid mRNA (PubMed:17268469). This interaction is required for the anterior localization of bicoid mRNA in the developing egg (PubMed:17268469). Plays a role in promoting mitochondrial autophagy (mitophagy) (PubMed:29307555)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MSB7", "ec_number_list": [], "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0000814 ESCRT II complex;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0043025 neuronal cell body;GO:0031902 late endosome membrane", "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0042981 regulation of apoptotic process;GO:0008104 intracellular protein localization;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VU87-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VUB4-1", "uniprot_id": [ { "id": "NPRL3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VUB4", "type": "external" } ], "mass": 68787.0, "length": 610, "protein_name": "GATOR complex protein NPRL3", "gene_name": "Nprl3", "organism": "Fruit fly", "refseq_name": "nitrogen permease regulator-like 3, isoform C", "refseq_ac": [ { "id": "NP_001261818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261818", "type": "external" } ], "gene_names_uniprotkb": "Nprl3; CG8783", "gene_names_refseq": "CG8783; Dmel\\CG8783; GATOR1; NPR3; Nplr3; Nprl3; nprl3", "protein_names_uniprotkb": "GATOR complex protein NPRL3; Nitrogen permease regulator 3-like protein", "protein_names_refseq": "CG8783-PC; Nprl3-PC; nitrogen permease regulator-like 3, isoform C", "tax_id": 7227, "disease": "familial focal epilepsy with variable foci 3 (Disease Ontology:DOID:0081423)", "pathway": " (dme:Dmel_CG8783)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10731132;12537569;12537572;18327897;23723238;24786828;25512509;27166823;27672113", "class_list": "", "function": "An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:25512509, PubMed:27166823). The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:23723238, PubMed:25512509, PubMed:27166823). The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid or complete starvation by inhibiting TORC1-dependent cell growth and promoting catabolic metabolism and autophagy (PubMed:23723238, PubMed:27166823). In addition, this inhibition of TORC1 is necessary to maintain female fertility under normal conditions and during periods of nutrient stress (PubMed:24786828, PubMed:25512509, PubMed:27672113). GATOR1 and GATOR2 act at different stages of oogenesis to regulate TORC1 in order to control meiotic entry and promote oocyte growth and development (PubMed:25512509). After exactly four mitotic cyst divisions, the GATOR1 complex members (Iml1, Nprl2 and Nprl3) down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition (PubMed:25512509). At later stages of oogenesis, the mio and Nup44A components of the GATOR2 complex inhibit GATOR1 and thus activate TORC1 to promote meiotic progression, and drive oocyte growth and development (PubMed:25512509)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4V1X9;Q95RI3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005764 lysosome;GO:0044754 autolysosome;GO:1990130 GATOR1 complex", "go_biological_process": "GO:0010898 positive regulation of triglyceride catabolic process;GO:0051301 cell division;GO:0010508 positive regulation of autophagy;GO:0032007 negative regulation of TOR signaling;GO:0016239 positive regulation of macroautophagy", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9VUB4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VUG4-1", "uniprot_id": [ { "id": "Q9VUG4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VUG4", "type": "external" } ], "mass": 12609.0, "length": 113, "protein_name": "Goddard", "gene_name": "gdrd", "organism": "Fruit fly", "refseq_name": "goddard", "refseq_ac": [ { "id": "NP_648713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648713", "type": "external" } ], "gene_names_uniprotkb": "gdrd; CG13477; Dmel\\CG13477; Dmel_CG13477", "gene_names_refseq": "CG13477; Dmel\\CG13477; gdrd", "protein_names_uniprotkb": "Goddard", "protein_names_refseq": "CG13477-PA; gdrd-PA; goddard", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13477)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0036126 sperm flagellum", "go_biological_process": "GO:0007291 sperm individualization", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VUG4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VUH5-1", "uniprot_id": [ { "id": "Q9VUH5_DROME", "url": "https://www.uniprot.org/uniprot/Q9VUH5", "type": "external" } ], "mass": 59492.0, "length": 508, "protein_name": "2.4.1.145; Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase b", "gene_name": "Mgat4b", "organism": "Fruit fly", "refseq_name": "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase b", "refseq_ac": [ { "id": "NP_648721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648721", "type": "external" } ], "gene_names_uniprotkb": "Mgat4b; CG17173; Dmel\\CG17173; Dmel_CG17173; MGAT; Magt4b; dMGAT4-2", "gene_names_refseq": "CG17173; Dmel\\CG17173; MGAT; Magt4b; Mgat4b; dMGAT4-2", "protein_names_uniprotkb": "2.4.1.145; Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase b", "protein_names_refseq": "CG17173-PA; Mgat4b-PA; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase b", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17173); (R-DME-975577)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" } ], "go_molecular_function": "GO:0008375 acetylglucosaminyltransferase activity;GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VUH5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VUI7-1", "uniprot_id": [ { "id": "Q9VUI7_DROME", "url": "https://www.uniprot.org/uniprot/Q9VUI7", "type": "external" } ], "mass": 88890.0, "length": 766, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG3349", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_648730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648730", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG3349; CG3349; Dmel_CG3349", "gene_names_refseq": "CG3349; Dmel\\CG3349", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG3349-PB; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3349)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007618 mating", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VUI7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VUM0-1", "uniprot_id": [ { "id": "MSH6_DROME", "url": "https://www.uniprot.org/uniprot/Q9VUM0", "type": "external" } ], "mass": 133136.0, "length": 1190, "protein_name": "Probable DNA mismatch repair protein Msh6", "gene_name": "Msh6", "organism": "Fruit fly", "refseq_name": "Msh6", "refseq_ac": [ { "id": "NP_648755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648755", "type": "external" } ], "gene_names_uniprotkb": "Msh6; CG7003", "gene_names_refseq": "CG7003; Dmel\\CG7003; MSH6; Msh6", "protein_names_uniprotkb": "Probable DNA mismatch repair protein Msh6", "protein_names_refseq": "CG7003-PA; Msh6-PA; Msh6", "tax_id": 7227, "disease": "hereditary nonpolyposis colorectal cancer type 5 (Disease Ontology:DOID:0070272); colorectal carcinoma (Disease Ontology:DOID:0080199); mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); urinary bladder cancer (Disease Ontology:DOID:11054); endometrial cancer (Disease Ontology:DOID:1380); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); osteosarcoma (Disease Ontology:DOID:3347); breast carcinoma (Disease Ontology:DOID:3459); Lynch syndrome (Disease Ontology:DOID:3883); primary ovarian insufficiency (Disease Ontology:DOID:5426)", "pathway": " (dme:Dmel_CG7003); (R-DME-5358565)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537572;17339220;18327897", "class_list": "", "function": "Involved in post-replicative DNA-mismatch repair., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 11, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B6IDV3", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0030983 mismatched DNA binding;GO:0140664 ATP-dependent DNA damage sensor activity", "go_cellular_component": "GO:0032301 MutSalpha complex;GO:0005634 nucleus", "go_biological_process": "GO:0000710 meiotic mismatch repair;GO:0006281 DNA repair;GO:0006298 mismatch repair", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VUM0-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VUR0-1", "uniprot_id": [ { "id": "UFSP2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VUR0", "type": "external" } ], "mass": 68251.0, "length": 607, "protein_name": "Probable Ufm1-specific protease 2", "gene_name": "Ufsp2", "organism": "Fruit fly", "refseq_name": "UFM1 specific peptidase 2", "refseq_ac": [ { "id": "NP_648779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648779", "type": "external" } ], "gene_names_uniprotkb": "Ufsp2; CG16979", "gene_names_refseq": "CG16979; Dmel\\CG16979; UfSP2; Ufsp2", "protein_names_uniprotkb": "Probable Ufm1-specific protease 2; 3.4.22.-; UfSP2", "protein_names_refseq": "CG16979-PA; UFM1 specific peptidase 2; Ufsp2-PA", "tax_id": 7227, "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); developmental and epileptic encephalopathy 106 (Disease Ontology:DOID:0070392); Beukes hip dysplasia (Disease Ontology:DOID:0111367)", "pathway": " (dme:Dmel_CG16979)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0071567 deUFMylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0012505 endomembrane system", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VUR0-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VUT8-1", "uniprot_id": [ { "id": "COMM2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VUT8", "type": "external" } ], "mass": 37728.0, "length": 343, "protein_name": "Protein commissureless 2", "gene_name": "comm2", "organism": "Fruit fly", "refseq_name": "comm2", "refseq_ac": [ { "id": "NP_648801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648801", "type": "external" } ], "gene_names_uniprotkb": "comm2; CG7554", "gene_names_refseq": "CG7554; Comm2; Dmel\\CG7554; comm2", "protein_names_uniprotkb": "Protein commissureless 2", "protein_names_refseq": "CG7554-PA; comm2-PA; comm2", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7554)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;24026811", "class_list": "", "function": "Essential for nerve cord development. Functions downstream of fra to control axon guidance across the central nervous system (CNS) midline., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8MZ29", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VUT8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VUY9-1", "uniprot_id": [ { "id": "PGM_DROME", "url": "https://www.uniprot.org/uniprot/Q9VUY9", "type": "external" } ], "mass": 60766.0, "length": 560, "protein_name": "Phosphoglucomutase 1", "gene_name": "Pgm1", "organism": "Fruit fly", "refseq_name": "phosphoglucose mutase 1", "refseq_ac": [ { "id": "NP_524675", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524675", "type": "external" } ], "gene_names_uniprotkb": "Pgm1; CG5165", "gene_names_refseq": "CG5165; Dmel\\CG5165; PGM-1; PGM1; PGM; Pgm-1; Pgm1; Pgm; dPgm; pgm", "protein_names_uniprotkb": "Phosphoglucomutase 1; 5.4.2.2; Glucose phosphomutase; PGM", "protein_names_refseq": "CG5165-PA; Pgm1-PA; phosphoglucomutase; phosphogluconate mutase; phosphoglucose mutase 1; phosphoglucose mutase", "tax_id": 7227, "disease": "congenital disorder of glycosylation It (Disease Ontology:DOID:0080570); endometrial cancer (Disease Ontology:DOID:1380); teratoma (Disease Ontology:DOID:3307)", "pathway": " (dme:Dmel_CG5165); (R-DME-3322077); (R-DME-6798695); (R-DME-70221); (R-DME-70370)", "pathway_count": 5, "publication_count": 9, "publication_id_list": "10731132;11102370;11290720;11560897;12049662;12537572;18327897;26235423;44190", "class_list": "", "function": "Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (PubMed:44190). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (PubMed:44190). This enzyme participates in both the breakdown and synthesis of glucose (PubMed:44190). Enzyme of the glycolytic pathway (Probable). Glycolysis is essential in glial cells but not in neurons; neurons rely on the citric acid cycle for their energy needs, and on lactate and alanine secreted into the hemolymph by glial cells to fuel it (PubMed:26235423)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q95VC1;Q9GN12;Q9GN65;Q9GN80;Q9GN99;Q9GNA0;Q9GNH5;Q9GNJ1;Q9GQ71;Q9GQ72;Q9GQ73;Q9GQ74;Q9GQ75;Q9GQ76;Q9GQ77;Q9GQ78;Q9GQ79;Q9GQ80", "ec_number_list": [ { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "5.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7", "type": "external" }, { "id": "5.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.-", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "3.5.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.28", "type": "external" }, { "id": "3.2.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "5.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.5", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.4.17.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.13", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004614 phosphoglucomutase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006006 glucose metabolic process;GO:0005978 glycogen biosynthetic process;GO:0019255 glucose 1-phosphate metabolic process;GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q9VUY9-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VV41-1", "uniprot_id": [ { "id": "OSGEP_DROME", "url": "https://www.uniprot.org/uniprot/Q9VV41", "type": "external" } ], "mass": 38486.0, "length": 347, "protein_name": "Probable tRNA N6-adenosine threonylcarbamoyltransferase", "gene_name": "Tcs3", "organism": "Fruit fly", "refseq_name": "Threonyl-carbamoyl synthesis 3", "refseq_ac": [ { "id": "NP_648880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648880", "type": "external" } ], "gene_names_uniprotkb": "Tcs3; CG4933", "gene_names_refseq": "CG4933; Dmel\\CG4933; Tcs3; kae1; l(3)72Fb; tcs3", "protein_names_uniprotkb": "Probable tRNA N6-adenosine threonylcarbamoyltransferase; 2.3.1.234; N6-L-threonylcarbamoyladenine synthase; t(6)A synthase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein Tcs3; tRNA threonylcarbamoyladenosine biosynthesis protein Tcs3", "protein_names_refseq": "CG4933-PA; Tcs3-PA; Threonyl-carbamoyl synthesis 3; black spot; lethal (3) 72Fb; tRNA adenosine(37) threonylcarbamoyltransferase complex, transferase subunit", "tax_id": 7227, "disease": "primary hypomagnesemia (Disease Ontology:DOID:0060879); Galloway-Mowat syndrome 3 (Disease Ontology:DOID:0080245); proteinuria (Disease Ontology:DOID:576)", "pathway": " (dme:Dmel_CG4933)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity., [UniProtKB, HAMAP]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.234", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.234", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0061711 tRNA N(6)-L-threonylcarbamoyladenine synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000408 EKC/KEOPS complex", "go_biological_process": "GO:1990145 maintenance of translational fidelity;GO:0002949 tRNA threonylcarbamoyladenosine modification;GO:0045948 positive regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VV41-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VV72-1", "uniprot_id": [ { "id": "MINP1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VV72", "type": "external" } ], "mass": 53571.0, "length": 467, "protein_name": "Multiple inositol polyphosphate phosphatase 1", "gene_name": "Mipp1", "organism": "Fruit fly", "refseq_name": "multiple inositol polyphosphate phosphatase 1, isoform C", "refseq_ac": [ { "id": "NP_001287082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287082", "type": "external" } ], "gene_names_uniprotkb": "Mipp1; CG4123", "gene_names_refseq": "CG4123; CK2082; Dmel\\CG4123; Mipp1; mipp1", "protein_names_uniprotkb": "Multiple inositol polyphosphate phosphatase 1; 2,3-BPG phosphatase; 2,3-bisphosphoglycerate 3-phosphatase; 3.1.3.62; 3.1.3.80", "protein_names_refseq": "CG4123-PC; Mipp1-PC; multiple inositol polyphosphate phosphatase 1, isoform C", "tax_id": 7227, "disease": "pontocerebellar hypoplasia type 16 (Disease Ontology:DOID:0112333); papillary thyroid carcinoma (Disease Ontology:DOID:3969)", "pathway": " (dme:Dmel_CG4123); (R-DME-1855231)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10087200;10731132;12537569;12537572;26628373;40245499", "class_list": "", "function": "Probable multiple inositol polyphosphate phosphatase that hydrolyzes 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo-inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology (PubMed:26628373). May have a dual substrate specificity, and function as a 2,3-bisphosphoglycerate 3-phosphatase hydrolyzing 2,3-bisphosphoglycerate to 2-phosphoglycerate. 2,3-bisphosphoglycerate (BPG) is formed as part of the Rapoport-Luebering glycolytic bypass (By similarity). Has a role in embryonic tracheal development where it localizes to the leading edge of actively migrating branches (PubMed:26628373). In these leading cells, enhances formation and/or maintenance of filopodia which may drive branch migration and elongation by cell-cell intercalation (PubMed:26628373). The function in tracheal morphogenesis is dependent on its inositol polyphosphate phosphatase activity (PubMed:26628373)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 2, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O96421;Q8SYN4;Q8T3I2", "ec_number_list": [ { "id": "3.1.3.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.62", "type": "external" }, { "id": "3.1.3.80", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.80", "type": "external" } ], "go_molecular_function": "GO:0003993 acid phosphatase activity;GO:0034417 bisphosphoglycerate 3-phosphatase activity;GO:0052745 inositol phosphate phosphatase activity;GO:0016158 inositol hexakisphosphate 3-phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0070062 extracellular exosome;GO:0009897 external side of plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0051491 positive regulation of filopodium assembly;GO:0007424 open tracheal system development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9VV72-1", "record_type": "protein", "filter_code": "0000000.0100111.100000.000000100000000000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VVA8-1", "uniprot_id": [ { "id": "TM258_DROME", "url": "https://www.uniprot.org/uniprot/Q9VVA8", "type": "external" } ], "mass": 8717.0, "length": 78, "protein_name": "Transmembrane protein 258", "gene_name": "kud", "organism": "Fruit fly", "refseq_name": "kuduk, isoform B", "refseq_ac": [ { "id": "NP_001246807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001246807", "type": "external" } ], "gene_names_uniprotkb": "kud; CG9669", "gene_names_refseq": "CG9669; Dmel\\CG9669; Kud; kud", "protein_names_uniprotkb": "Transmembrane protein 258; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258; Oligosaccharyl transferase subunit TMEM258; Protein kuduk; Transmembrane protein 258 homolog", "protein_names_refseq": "CG9669-PB; kud-PB; kuduk, isoform B; kuduk", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9669)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;28716842", "class_list": "", "function": "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). In addition may regulates nuclear envelope (NE) architecture and nuclear positioning through the linker of nucleoskeleton and cytoskeleton (LINC)-dependent and -independent mechanisms (PubMed:28716842)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0062062 oligosaccharyltransferase complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0005640 nuclear outer membrane;GO:0160226 oligosaccharyltransferase complex A;GO:0160227 oligosaccharyltransferase complex B", "go_biological_process": "GO:0006487 protein N-linked glycosylation;GO:0034976 response to endoplasmic reticulum stress;GO:0006998 nuclear envelope organization;GO:0007097 nuclear migration;GO:0180058 protein co-translational transfer of dolichol-linked oligosaccharide", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VVA8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VVG4-1", "uniprot_id": [ { "id": "EXOC1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VVG4", "type": "external" } ], "mass": 102695.0, "length": 889, "protein_name": "Exocyst complex component 1", "gene_name": "Sec3", "organism": "Fruit fly", "refseq_name": "secretory 3", "refseq_ac": [ { "id": "NP_648976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648976", "type": "external" } ], "gene_names_uniprotkb": "Sec3; CG3885", "gene_names_refseq": "CG3885; Dmel\\CG3885; Sec3; sec3", "protein_names_uniprotkb": "Exocyst complex component 1; Exocyst complex component Sec3", "protein_names_refseq": "CG3885-PA; Sec3 ortholog; Sec3-PA; secretory 3", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG3885); (R-DME-264876); (R-DME-5620916)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18327897", "class_list": "", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95R79", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0000145 exocyst", "go_biological_process": "GO:0015031 protein transport;GO:0000281 mitotic cytokinesis;GO:0006887 exocytosis;GO:0006893 Golgi to plasma membrane transport;GO:0090148 membrane fission", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VVG4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VVH3-1", "uniprot_id": [ { "id": "MIC13_DROME", "url": "https://www.uniprot.org/uniprot/Q9VVH3", "type": "external" } ], "mass": 13750.0, "length": 122, "protein_name": "MICOS complex subunit MIC13 homolog QIL1", "gene_name": "QIL1", "organism": "Fruit fly", "refseq_name": "QIL1", "refseq_ac": [ { "id": "NP_648983", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_648983", "type": "external" } ], "gene_names_uniprotkb": "QIL1; CG7603", "gene_names_refseq": "CG7603; Dmel\\CG7603; MIC13; QIL1", "protein_names_uniprotkb": "MICOS complex subunit MIC13 homolog QIL1", "protein_names_refseq": "CG7603-PA; QIL1-PA; QIL1", "tax_id": 7227, "disease": "combined oxidative phosphorylation deficiency 37 (Disease Ontology:DOID:0111499)", "pathway": " (dme:Dmel_CG7603)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;25997101", "class_list": "", "function": "Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0044284 mitochondrial crista junction;GO:0061617 MICOS complex", "go_biological_process": "GO:0042407 cristae formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VVH3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VVS4-1", "uniprot_id": [ { "id": "MED11_DROME", "url": "https://www.uniprot.org/uniprot/Q9VVS4", "type": "external" } ], "mass": 19639.0, "length": 176, "protein_name": "Mediator of RNA polymerase II transcription subunit 11", "gene_name": "MED11", "organism": "Fruit fly", "refseq_name": "mediator complex subunit 11", "refseq_ac": [ { "id": "NP_649057", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649057", "type": "external" } ], "gene_names_uniprotkb": "MED11; CG6884; Med21", "gene_names_refseq": "BcDNA:GH01072; CG6884; Dmel\\CG6884; MED11; Med11; Med21; anon-WO0153538.71; dMED21; med11", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 11; Mediator complex subunit 11; dMED21", "protein_names_refseq": "CG6884-PA; MED11-PA; RNA poll II transcription mediator; mediator complex subunit 11", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6884)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12021283;12537569;12537572", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VVS4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VVT9-1", "uniprot_id": [ { "id": "NIJB_DROME", "url": "https://www.uniprot.org/uniprot/Q9VVT9", "type": "external" } ], "mass": 19930.0, "length": 181, "protein_name": "Ninjurin-B", "gene_name": "NijB", "organism": "Fruit fly", "refseq_name": "ninjurin B", "refseq_ac": [ { "id": "NP_649068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649068", "type": "external" } ], "gene_names_uniprotkb": "NijB; CG11637", "gene_names_refseq": "CG11637; Dmel\\CG11637; NINJ-B; NijB; nijB", "protein_names_uniprotkb": "Ninjurin-B; dNINJ-B", "protein_names_refseq": "CG11637-PA; NijB-PA; ninjurin B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11637)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;16815999;33472215", "class_list": "", "function": "Effector of non-apoptotic necrotic cell death that mediates plasma membrane rupture (cytolysis): oligomerizes in response to death stimuli and promotes plasma membrane rupture by introducing hydrophilic faces of 2 alpha helices into the hydrophobic membrane, leading to release intracellular molecules that propagate the inflammatory response (PubMed:33472215). Also acts as a homophilic transmembrane adhesion molecule that promotes cell adhesion by mediating homophilic interactions via its extracellular region (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4V5W5", "ec_number_list": [], "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0042246 tissue regeneration;GO:0031640 killing of cells of another organism;GO:0019835 cytolysis;GO:0012501 programmed cell death", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VVT9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VVV2-1", "uniprot_id": [ { "id": "OSTA_DROME", "url": "https://www.uniprot.org/uniprot/Q9VVV2", "type": "external" } ], "mass": 37866.0, "length": 328, "protein_name": "Organic solute transporter alpha-like protein", "gene_name": "CG6836", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_649079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649079", "type": "external" } ], "gene_names_uniprotkb": "CG6836", "gene_names_refseq": "CG6836; Dmel\\CG6836", "protein_names_uniprotkb": "Organic solute transporter alpha-like protein; Solute carrier family 51 subunit alpha homolog", "protein_names_refseq": "CG6836-PA; uncharacterized protein", "tax_id": 7227, "disease": "chromosome 3q29 microdeletion syndrome (Disease Ontology:DOID:0060419); progressive familial intrahepatic cholestasis (Disease Ontology:DOID:0070221)", "pathway": " (dme:Dmel_CG6836)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Probable transporter., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q8T0K0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VVV2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VVW8-1", "uniprot_id": [ { "id": "NNRD_DROME", "url": "https://www.uniprot.org/uniprot/Q9VVW8", "type": "external" } ], "mass": 32153.0, "length": 300, "protein_name": "ATP-dependent (S)-NAD(P)H-hydrate dehydratase", "gene_name": "Naxd", "organism": "Fruit fly", "refseq_name": "NAD(P)HX dehydratase", "refseq_ac": [ { "id": "NP_649090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649090", "type": "external" } ], "gene_names_uniprotkb": "Naxd; CG10424", "gene_names_refseq": "CG10424; Dmel\\CG10424; Naxd", "protein_names_uniprotkb": "ATP-dependent (S)-NAD(P)H-hydrate dehydratase; 4.2.1.93; ATP-dependent NAD(P)HX dehydratase", "protein_names_refseq": "CG10424-PA; NAD(P)HX dehydratase; Naxd-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10424); (R-DME-196807)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.93", "type": "external" } ], "go_molecular_function": "GO:0047453 ATP-dependent NAD(P)H-hydrate dehydratase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0046496 nicotinamide nucleotide metabolic process;GO:0110051 metabolite repair", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VVW8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VVX5-1", "uniprot_id": [ { "id": "MBOA5_DROME", "url": "https://www.uniprot.org/uniprot/Q9VVX5", "type": "external" } ], "mass": 57394.0, "length": 497, "protein_name": "Lysophospholipid acyltransferase 5", "gene_name": "nes", "organism": "Fruit fly", "refseq_name": "nessy, isoform A", "refseq_ac": [ { "id": "NP_524157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524157", "type": "external" } ], "gene_names_uniprotkb": "nes; CG9655; nessy", "gene_names_refseq": "CG9655; Dmel\\CG9655; Nes; nes", "protein_names_uniprotkb": "Lysophospholipid acyltransferase 5; 1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerophosphoserine O-acyltransferase; 2.3.1.23; 2.3.1.n6; LPCAT; LPLAT 5; LPSAT; Lyso-PC acyltransferase; Lyso-PS acyltransferase; Lysophosphatidylcholine acyltransferase; Lysophosphatidylserine acyltransferase; Membrane-bound O-acyltransferase domain-containing protein 5; Nes; O-acyltransferase domain-containing protein 5; Protein nessy", "protein_names_refseq": "CG9655-PA; nes-PA; nessy, isoform A; nessy", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9655); (R-DME-1482788); (R-DME-1482801); (R-DME-1482839)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "10446276;10731132;12537569;12537572;18327897;19864461", "class_list": "", "function": "Acyltransferase that mediates the acylation of lysophospholipids to produce phospholipids (glycerophospholipids). Highest activity with lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) producing phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity), but also converts lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) to phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Has a preference for unsaturated fatty acids of at least 16 carbons such as oleoyl-CoA ((9Z)-octadecenoyl-CoA) and palmitoleoyl-CoA ((9Z)-hexadecenoyl-CoA). Glycerophospholipids are important structural and functional components of cellular membrane, acyl-chain remodeling regulates the molecular species distribution of glycerophospholipids which can affect membrane fluidity and curvature. Essential for fertility and viability together with Oysgedart (Oys). Required for germ cells to migrate into the mesoderm., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4V238;Q9XYV9", "ec_number_list": [ { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.n6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6", "type": "external" }, { "id": "2.3.1.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0071617 lysophospholipid acyltransferase activity;GO:0106263 1-acylglycerophosphoserine O-acyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0007009 plasma membrane organization;GO:0006656 phosphatidylcholine biosynthetic process;GO:0036152 phosphatidylethanolamine acyl-chain remodeling;GO:0008354 germ cell migration;GO:0007291 sperm individualization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VVX5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VW51-1", "uniprot_id": [ { "id": "ELL_DROME", "url": "https://www.uniprot.org/uniprot/Q9VW51", "type": "external" } ], "mass": 114915.0, "length": 1059, "protein_name": "RNA polymerase II elongation factor Ell", "gene_name": "Ell", "organism": "Fruit fly", "refseq_name": "suppressor of triplolethal, isoform B", "refseq_ac": [ { "id": "NP_001163477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163477", "type": "external" } ], "gene_names_uniprotkb": "Ell; CG32217; Su(Tpl)", "gene_names_refseq": "0854/01; CG32217; CG8037; CR32216; Dmel\\CG32217; ELL; Ell; SR3-4A; SS3-4; SY3-1; Su(Tpl)/; Su(Tpl); dELL; dEll; l (3)76BD; l(3)76BDs; l(3)S000606; l(3)S085401", "protein_names_uniprotkb": "RNA polymerase II elongation factor Ell; dELL", "protein_names_refseq": "CG32217-PB; Su(Tpl)-PB; eleven-nineteen lysine-rich leukemia; elongation factor RNA polymerase II; suppressor of GMR-sina 3-4; suppressor of triplolethal, isoform B", "tax_id": 7227, "disease": "autosomal recessive nonsyndromic deafness 49 (Disease Ontology:DOID:0110506); cancer (Disease Ontology:DOID:162)", "pathway": " (dme:Dmel_CG32217); (R-DME-112382); (R-DME-351906); (R-DME-674695); (R-DME-6796648); (R-DME-6807505); (R-DME-75955)", "pathway_count": 7, "publication_count": 6, "publication_id_list": "10731132;11689450;12537569;12537572;22195968;23932780", "class_list": "", "function": "Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:11689450). Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95VE6", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0070063 RNA polymerase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0008023 transcription elongation factor complex;GO:0000785 chromatin;GO:0000791 euchromatin", "go_biological_process": "GO:0034243 regulation of transcription elongation by RNA polymerase II;GO:1905382 positive regulation of snRNA transcription by RNA polymerase II;GO:0034605 cellular response to heat;GO:0045893 positive regulation of DNA-templated transcription;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VW51-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VWB4-1", "uniprot_id": [ { "id": "Q9VWB4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VWB4", "type": "external" } ], "mass": 40993.0, "length": 362, "protein_name": "Serpin 77Bb", "gene_name": "Spn77Bb", "organism": "Fruit fly", "refseq_name": "serpin 77Bb", "refseq_ac": [ { "id": "NP_649206", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_649206", "type": "external" } ], "gene_names_uniprotkb": "Spn77Bb; CG6266; CG6663; Dmel\\CG6663; Dmel_CG6663; FBgn0036969; Spn77", "gene_names_refseq": "CG6266; CG6663; Dmel\\CG6663; FBgn0036969; Spn77Bb; Spn77", "protein_names_uniprotkb": "Serpin 77Bb", "protein_names_refseq": "CG6663-PA; Spn77Bb-PA; serpin 77Bb", "tax_id": 7227, "disease": "osteogenesis imperfecta type 10 (Disease Ontology:DOID:0110346); preterm premature rupture of the membranes (Disease Ontology:DOID:0111144); liver cirrhosis (Disease Ontology:DOID:5082)", "pathway": " (dme:Dmel_CG6663); (R-DME-114608); (R-DME-1650814); (R-DME-381426); (R-DME-6798695); (R-DME-8939242); (R-DME-8957275); (R-DME-9855719); (R-DME-9948001)", "pathway_count": 9, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9VWB5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007320 insemination;GO:0050776 regulation of immune response", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VWB4-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VWD4-1", "uniprot_id": [ { "id": "Y4230_DROME", "url": "https://www.uniprot.org/uniprot/Q9VWD4", "type": "external" } ], "mass": 66288.0, "length": 580, "protein_name": "Probable RNA-binding protein CG14230", "gene_name": "CG14230", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_608349", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_608349", "type": "external" } ], "gene_names_uniprotkb": "CG14230", "gene_names_refseq": "CG14230; Dmel\\CG14230; Nol8; anon-18DEe; cg14230; clone 9.42", "protein_names_uniprotkb": "Probable RNA-binding protein CG14230", "protein_names_refseq": "CG14230-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14230); (R-DME-72163); (R-DME-72203); (R-DME-9770562)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10731132;12537572;17372656;18327897", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0016607 nuclear speck", "go_biological_process": "GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VWD4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VWH8-1", "uniprot_id": [ { "id": "KISH_DROME", "url": "https://www.uniprot.org/uniprot/Q9VWH8", "type": "external" } ], "mass": 8176.0, "length": 72, "protein_name": "Protein kish", "gene_name": "ksh", "organism": "Fruit fly", "refseq_name": "kish", "refseq_ac": [ { "id": "NP_652499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_652499", "type": "external" } ], "gene_names_uniprotkb": "ksh; CG14199", "gene_names_refseq": "CG14199; Dmel\\CG14199; ksh", "protein_names_uniprotkb": "Protein kish", "protein_names_refseq": "CG14199-PB; kish; ksh-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14199)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537572;19942856", "class_list": "", "function": "Involved in the early part of the secretory pathway., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0009306 protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VWH8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VWL5-1", "uniprot_id": [ { "id": "INX5_DROME", "url": "https://www.uniprot.org/uniprot/Q9VWL5", "type": "external" } ], "mass": 48978.0, "length": 419, "protein_name": "Innexin inx5", "gene_name": "Inx5", "organism": "Fruit fly", "refseq_name": "innexin 5", "refseq_ac": [ { "id": "NP_573353", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573353", "type": "external" } ], "gene_names_uniprotkb": "Inx5; CG7537", "gene_names_refseq": "CG7537; Dm-inx5; Dmel\\CG7537; FBpp0074467; Innexin5; Inx5; inx-5; inx5", "protein_names_uniprotkb": "Innexin inx5", "protein_names_refseq": "CG7537-PB; Innexin-5; Inx5-PB; innexin 5; inx5", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7537)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;11960713;12537572", "class_list": "", "function": "Structural component of the gap junctions., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8WHD8;Q8MZL3", "ec_number_list": [], "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005921 gap junction", "go_biological_process": "GO:0034220 monoatomic ion transmembrane transport;GO:0007602 phototransduction;GO:0010496 intercellular transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VWL5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VWN5-1", "uniprot_id": [ { "id": "MINY3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VWN5", "type": "external" } ], "mass": 61755.0, "length": 560, "protein_name": "Ubiquitin carboxyl-terminal hydrolase MINDY-3 homolog", "gene_name": "Dmel\\CG7332; mindy3", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001285417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285417", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG7332; mindy3; CG7332; Dmel_CG7332", "gene_names_refseq": "CG7332; Dmel\\CG7332", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase MINDY-3 homolog; 3.4.19.12; Deubiquitinating enzyme MINDY-3; Protein CARP homolog", "protein_names_refseq": "CG7332-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7332)", "pathway_count": 1, "publication_count": 16, "publication_id_list": "10731132;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357;28604694;33925313;40245499", "class_list": "", "function": "Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 7, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 7, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 7, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis;GO:0071108 protein K48-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 2.5, "record_id": "Q9VWN5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VWN9-1", "uniprot_id": [ { "id": "ZSWM8_DROME", "url": "https://www.uniprot.org/uniprot/Q9VWN9", "type": "external" } ], "mass": 223592.0, "length": 2103, "protein_name": "Zinc finger SWIM domain-containing protein 8 homolog", "gene_name": "Dora", "organism": "Fruit fly", "refseq_name": "dorado, isoform B", "refseq_ac": [ { "id": "NP_573336", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573336", "type": "external" } ], "gene_names_uniprotkb": "Dora; CG34401", "gene_names_refseq": "CG15037; CG17757; CG32542; CG34401; CG7307; CG7317; Dmel\\CG34401; Dora; Zswim8; dora; pelado; pldo", "protein_names_uniprotkb": "Zinc finger SWIM domain-containing protein 8 homolog; Protein dorado", "protein_names_refseq": "CG34401-PB; Dora-PB; dorado, isoform B; pelado", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG34401)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;33184237", "class_list": "", "function": "Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (PubMed:33184237). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO1, thereby exposing miRNAs for degradation (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A4D6K2F2;Q95ST9;R9PY27", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0031462 Cul2-RING ubiquitin ligase complex;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:2000627 positive regulation of miRNA catabolic process;GO:0140958 target-directed miRNA degradation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VWN9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VWS2-1", "uniprot_id": [ { "id": "NUP35_DROME", "url": "https://www.uniprot.org/uniprot/Q9VWS2", "type": "external" } ], "mass": 35099.0, "length": 331, "protein_name": "Nucleoporin Nup35", "gene_name": "Nup35", "organism": "Fruit fly", "refseq_name": "nucleoporin 35kDa", "refseq_ac": [ { "id": "NP_573314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573314", "type": "external" } ], "gene_names_uniprotkb": "Nup35; CG6540; Nup53", "gene_names_refseq": "CG6540; Dmel\\CG6540; Nup35; Nup53; nup35", "protein_names_uniprotkb": "Nucleoporin Nup35; 35 kDa nucleoporin; Nuclear pore complex protein Nup35; Nucleoporin Nup53", "protein_names_refseq": "CG6540-PA; Nup35-PA; nucleoporin 35kDa", "tax_id": 7227, "disease": "intestinal pseudo-obstruction (Disease Ontology:DOID:0080072)", "pathway": " (dme:Dmel_CG6540); (R-DME-159227); (R-DME-159230); (R-DME-159231); (R-DME-159236); (R-DME-1855170); (R-DME-1855196); (R-DME-1855229); (R-DME-3108214); (R-DME-3301854); (R-DME-3371453); (R-DME-4085377); (R-DME-4551638); (R-DME-4615885); (R-DME-9615933)", "pathway_count": 15, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;22718353", "class_list": "", "function": "Functions as a component of the nuclear pore complex (NPC) (By similarity). May have a role in the organization of the inner nuclear membrane proteins at the nuclear envelope together with Nup154 (PubMed:22718353)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0003676 nucleic acid binding;GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005635 nuclear envelope;GO:0031965 nuclear membrane;GO:0044613 nuclear pore central transport channel", "go_biological_process": "GO:0006999 nuclear pore organization;GO:0006913 nucleocytoplasmic transport;GO:0051028 mRNA transport;GO:0006607 NLS-bearing protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VWS2-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VWS9-1", "uniprot_id": [ { "id": "Q9VWS9_DROME", "url": "https://www.uniprot.org/uniprot/Q9VWS9", "type": "external" } ], "mass": 38243.0, "length": 332, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG6481", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_573307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573307", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG6481; CG6481; Dmel_CG6481; FBgn0030936", "gene_names_refseq": "CG6481; Dmel\\CG6481; FBgn0030936", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG6481-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG6481)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VWS9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VWY6-1", "uniprot_id": [ { "id": "TAF8_DROME", "url": "https://www.uniprot.org/uniprot/Q9VWY6", "type": "external" } ], "mass": 36649.0, "length": 328, "protein_name": "Transcription initiation factor TFIID subunit 8", "gene_name": "Taf8", "organism": "Fruit fly", "refseq_name": "TBP-associated factor 8", "refseq_ac": [ { "id": "NP_523397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523397", "type": "external" } ], "gene_names_uniprotkb": "Taf8; CG7128; pds; prod", "gene_names_refseq": "CG7128; Dmel\\CG7128; HL-VIII; Prodos; TAF8; TAF[[II]]; TAF; TFIID; Taf8; dmTAF8; l(1)16Fg; pds; prod; pro; taf8", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 8; Protein prodos", "protein_names_refseq": "CG7128-PA; TBP-associated factor 8; TBP-associated factor; Taf8-PA; prodos", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG7128); (R-DME-674695); (R-DME-6804756); (R-DME-6807505); (R-DME-73776); (R-DME-73779); (R-DME-75953); (R-DME-76042)", "pathway_count": 8, "publication_count": 5, "publication_id_list": "10731132;11134347;12537569;12537572;18327897", "class_list": "", "function": "TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O18398;Q8SYE2", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0006367 transcription initiation at RNA polymerase II promoter", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VWY6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VX39-1", "uniprot_id": [ { "id": "TM41_DROME", "url": "https://www.uniprot.org/uniprot/Q9VX39", "type": "external" } ], "mass": 35833.0, "length": 320, "protein_name": "Transmembrane protein 41 homolog", "gene_name": "stas", "organism": "Fruit fly", "refseq_name": "stasimon, isoform B", "refseq_ac": [ { "id": "NP_001138217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138217", "type": "external" } ], "gene_names_uniprotkb": "stas; CG8408", "gene_names_refseq": "CG8408; Dmel\\CG8408; Tmem41b; stas", "protein_names_uniprotkb": "Transmembrane protein 41 homolog; Protein stasimon", "protein_names_refseq": "CG8408-PB; stas-PB; stasimon, isoform B; stasimon; stymied in smn", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG8408)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;23063131;40245499", "class_list": "", "function": "Required in cholinergic neurons, but not in motor neurons, for normal neurotransmitter release by motor neurons. Involved in muscle growth., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "B7Z102;Q95RT5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0032224 positive regulation of synaptic transmission, cholinergic;GO:0000045 autophagosome assembly;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9VX39-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VXB5-1", "uniprot_id": [ { "id": "RM22_DROME", "url": "https://www.uniprot.org/uniprot/Q9VXB5", "type": "external" } ], "mass": 26953.0, "length": 233, "protein_name": "Large ribosomal subunit protein uL22m", "gene_name": "mRpL22", "organism": "Fruit fly", "refseq_name": "mitochondrial ribosomal protein L22", "refseq_ac": [ { "id": "NP_523379", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_523379", "type": "external" } ], "gene_names_uniprotkb": "mRpL22; CG4742", "gene_names_refseq": "CG4742; Dmel\\CG4742; L22; mRpL22", "protein_names_uniprotkb": "Large ribosomal subunit protein uL22m; 39S ribosomal protein L22, mitochondrial; L22mt; MRP-L22", "protein_names_refseq": "CG4742-PA; mRpL22-PA; mitochondrial ribosomal protein L22; ribosomal protein L22", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG4742); (R-DME-5389840); (R-DME-5419276); (R-DME-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "10731132;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8SZC3", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9VXB5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VXH9-1", "uniprot_id": [ { "id": "WASC4_DROME", "url": "https://www.uniprot.org/uniprot/Q9VXH9", "type": "external" } ], "mass": 127348.0, "length": 1102, "protein_name": "WASH complex subunit 4", "gene_name": "SWIP", "organism": "Fruit fly", "refseq_name": "strumpellin and WASH-interacting protein", "refseq_ac": [ { "id": "NP_573116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573116", "type": "external" } ], "gene_names_uniprotkb": "SWIP; CG13957", "gene_names_refseq": "CG13957; Dmel\\CG13957; KIAA1033; SWIP; p116; swip", "protein_names_uniprotkb": "WASH complex subunit 4; Strumpellin and WASH-interacting protein homolog; WASH complex subunit SWIP homolog", "protein_names_refseq": "CG13957-PB; SWIP-PB; strumpellin and WASH-interacting protein", "tax_id": 7227, "disease": "autosomal recessive intellectual developmental disorder 43 (Disease Ontology:DOID:0081207); Wiskott-Aldrich syndrome (Disease Ontology:DOID:9169)", "pathway": " (dme:Dmel_CG13957)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;20498093;25739458", "class_list": "", "function": "Acts at least in part as component of the WASH complex which may regulate wash nucleation-promoting factor (NPF) activity and is required for its membrane targeting during endosomal sorting (By similarity). During embryogenesis, not involved in the wash-dependent developmental migration of hemocytes anteriorly from the tail (PubMed:25739458)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 2, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005768 endosome;GO:0031901 early endosome membrane;GO:0071203 WASH complex", "go_biological_process": "GO:0015031 protein transport;GO:0045785 positive regulation of cell adhesion;GO:0007032 endosome organization;GO:0016197 endosomal transport;GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VXH9-1", "record_type": "protein", "filter_code": "0000000.0000111.010000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VXK6-1", "uniprot_id": [ { "id": "IF5_DROME", "url": "https://www.uniprot.org/uniprot/Q9VXK6", "type": "external" } ], "mass": 51700.0, "length": 464, "protein_name": "Eukaryotic translation initiation factor 5", "gene_name": "eIF5", "organism": "Fruit fly", "refseq_name": "eukaryotic translation initiation factor 5, isoform B", "refseq_ac": [ { "id": "NP_573098", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_573098", "type": "external" } ], "gene_names_uniprotkb": "eIF5; CG9177", "gene_names_refseq": "CG9177; Dmel\\CG9177; EIF5; EIf5; anon-EST:fe3C6; eIF5", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 5; eIF-5", "protein_names_refseq": "CG9177-PB; anon-fast-evolving-3C6; eIF5-PB; eukaryotic translation initiation factor 5, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9177); (R-DME-72702)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18327897", "class_list": "", "function": "Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V4K0;Q0KHS2", "ec_number_list": [], "go_molecular_function": "GO:0071074 eukaryotic initiation factor eIF2 binding;GO:0005525 GTP binding;GO:0003743 translation initiation factor activity;GO:0005092 GDP-dissociation inhibitor activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006413 translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VXK6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VXS3-1", "uniprot_id": [ { "id": "Q9VXS3_DROME", "url": "https://www.uniprot.org/uniprot/Q9VXS3", "type": "external" } ], "mass": 44727.0, "length": 405, "protein_name": "Uncharacterized protein", "gene_name": "Dmel\\CG12708", "organism": "Fruit fly", "refseq_name": "uncharacterized protein, isoform B", "refseq_ac": [ { "id": "NP_001138199", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138199", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG12708; CG12708; Dmel_CG12708", "gene_names_refseq": "CG12708; Dmel\\CG12708", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG12708-PB; uncharacterized protein, isoform B", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12708)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VXS3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VXY4-1", "uniprot_id": [ { "id": "TMA16_DROME", "url": "https://www.uniprot.org/uniprot/Q9VXY4", "type": "external" } ], "mass": 21136.0, "length": 180, "protein_name": "Translation machinery-associated protein 16 homolog", "gene_name": "CG15027", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_572999", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572999", "type": "external" } ], "gene_names_uniprotkb": "CG15027", "gene_names_refseq": "BcDNA:SD22530; CG15027; Dmel\\CG15027", "protein_names_uniprotkb": "Translation machinery-associated protein 16 homolog", "protein_names_refseq": "CG15027-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15027)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MRV0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9VXY4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VY86-1", "uniprot_id": [ { "id": "TM2D2_DROME", "url": "https://www.uniprot.org/uniprot/Q9VY86", "type": "external" } ], "mass": 24360.0, "length": 224, "protein_name": "TM2 domain-containing protein amaretto", "gene_name": "amrt", "organism": "Fruit fly", "refseq_name": "amaretto", "refseq_ac": [ { "id": "NP_001033842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033842", "type": "external" } ], "gene_names_uniprotkb": "amrt; CG11103", "gene_names_refseq": "BcDNA:LP03404; CG11103; Dmel\\CG11103; amrt", "protein_names_uniprotkb": "TM2 domain-containing protein amaretto; TM2D2", "protein_names_refseq": "CG11103-PC; amaretto; amrt-PC", "tax_id": 7227, "disease": "Alzheimer's disease (Disease Ontology:DOID:10652)", "pathway": " (dme:Dmel_CG11103)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;34905536", "class_list": "", "function": "Positive regulator of Notch signaling (PubMed:34905536). Maternal neurogenic factor involved in Notch signaling-dependent neuroectodermal specification during early embryogenesis (PubMed:34905536). Functions cooperatively with amx/TM2D3 and bisc/TM2D1 (PubMed:34905536)., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0045747 positive regulation of Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VY86-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VYD7-1", "uniprot_id": [ { "id": "TIM9_DROME", "url": "https://www.uniprot.org/uniprot/Q9VYD7", "type": "external" } ], "mass": 11098.0, "length": 95, "protein_name": "Mitochondrial import inner membrane translocase subunit Tim9", "gene_name": "Tim9a", "organism": "Fruit fly", "refseq_name": "Tim9a, isoform B", "refseq_ac": [ { "id": "NP_001285208", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285208", "type": "external" } ], "gene_names_uniprotkb": "Tim9a; CG1660; Dmel\\CG1660; Dmel_CG1660; Tim9", "gene_names_refseq": "CG1660; Dmel\\CG1660; Tim9a; Tim9", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit Tim9", "protein_names_refseq": "CG1660-PB; Tim9a, isoform B; Tim9a-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1660); (R-DME-1268020)", "pathway_count": 2, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space., [UniProtKB, UniProtKB, UniProtKB]; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1ECC2", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0140318 protein transporter activity", "go_cellular_component": "GO:0042719 mitochondrial intermembrane space chaperone complex;GO:0005743 mitochondrial inner membrane;GO:0042721 TIM22 mitochondrial import inner membrane insertion complex", "go_biological_process": "GO:0015031 protein transport;GO:0045039 protein insertion into mitochondrial inner membrane", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VYD7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VYQ0-1", "uniprot_id": [ { "id": "MSHN_DROME", "url": "https://www.uniprot.org/uniprot/Q9VYQ0", "type": "external" } ], "mass": 19908.0, "length": 172, "protein_name": "Moonshiner", "gene_name": "moon", "organism": "Fruit fly", "refseq_name": "moonshiner", "refseq_ac": [ { "id": "NP_572784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572784", "type": "external" } ], "gene_names_uniprotkb": "moon; CG12721", "gene_names_refseq": "BcDNA:RE60404; CG12721; Dmel\\CG12721; MOON; Moonshiner; Moon; moon", "protein_names_uniprotkb": "Moonshiner", "protein_names_refseq": "CG12721-PA; moon-PA; moonshiner", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12721)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;28847004", "class_list": "", "function": "Part of a rhi-dependent transcription machinery that enables the generation of piRNA precursors from heterochromatin while maintaining the suppression of transposon-encoded promoters and enhancers. Moonshiner/CG12721 recruits transcriptional machinery to heterochromatin to initiate the bidirectional transcription of piRNA clusters. Functions by forming a complex with transcription initiation factors TfIIA-S and Trf2, and interacting with del which is part of the RDC (rhi, del and cuff) complex that binds to repressive H3K9me3 marks in the chromatin. This mechanism allows transcription to occur in piRNA clusters despite the lack of proper promoter elements and in the presence of the repressive H3K9me3 mark., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017025 TBP-class protein binding", "go_cellular_component": "GO:0000792 heterochromatin;GO:0005672 transcription factor TFIIA complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0140543 positive regulation of piRNA transcription", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VYQ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VYQ8-1", "uniprot_id": [ { "id": "UBP7_DROME", "url": "https://www.uniprot.org/uniprot/Q9VYQ8", "type": "external" } ], "mass": 130446.0, "length": 1129, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 7", "gene_name": "Usp7", "organism": "Fruit fly", "refseq_name": "Ubiquitin-specific protease 7, isoform B", "refseq_ac": [ { "id": "NP_572779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572779", "type": "external" } ], "gene_names_uniprotkb": "Usp7; CG1490; Dmel\\CG1490; Dmel_CG1490; Q9VYQ8; USP7; Usp-7; usp7", "gene_names_refseq": "CG1490; Dmel\\CG1490; Q9VYQ8; USP7; Usp-7; Usp7; usp7", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 7; 3.4.19.12; Deubiquitinating enzyme 7; Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7", "protein_names_refseq": "CG1490-PB; Ubiquitin-specific protease 7, isoform B; Usp7-PB; ubiquitin-specific protease 7", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG1490); (R-DME-5689880); (R-DME-6781823); (R-DME-6782135); (R-DME-6782210); (R-DME-6804757); (R-DME-8866652); (R-DME-8948747)", "pathway_count": 8, "publication_count": 12, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;18327897;25589440;26109356;26109357", "class_list": "", "function": "Hydrolase that deubiquitinates target proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B5RJQ7", "ec_number_list": [ { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0032991 protein-containing complex;GO:0000792 heterochromatin;GO:0005700 polytene chromosome", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability;GO:0035331 negative regulation of hippo signaling", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "Q9VYQ8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VYW7-1", "uniprot_id": [ { "id": "Q9VYW7_DROME", "url": "https://www.uniprot.org/uniprot/Q9VYW7", "type": "external" } ], "mass": 20412.0, "length": 180, "protein_name": "Uncharacterized protein", "gene_name": "BcDNA:AT28768", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_572734", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_572734", "type": "external" } ], "gene_names_uniprotkb": "BcDNA:AT28768; CG2533; Dmel\\CG2533; Dmel_CG2533", "gene_names_refseq": "BcDNA:AT28768; CG2533; Dmel\\CG2533", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "CG2533-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2533)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VYW7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VYZ1-1", "uniprot_id": [ { "id": "OR10A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VYZ1", "type": "external" } ], "mass": 46765.0, "length": 406, "protein_name": "Odorant receptor 10a", "gene_name": "Or10a", "organism": "Fruit fly", "refseq_name": "odorant receptor 10a", "refseq_ac": [ { "id": "NP_511122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_511122", "type": "external" } ], "gene_names_uniprotkb": "Or10a; CG17867", "gene_names_refseq": "10B.1; 10a; CG17867; DOR92; Dmel\\CG17867; Gr10a; OR10a; Or10a", "protein_names_uniprotkb": "Odorant receptor 10a", "protein_names_refseq": "CG17867-PB; Or10a-PB; odorant receptor 10a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17867)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;10943836;12537572;16615896;20628035;22038943", "class_list": "", "function": "Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to esters, and specifically to ethyl hexanoate, benzaldehyde, and acetophenone., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004984 olfactory receptor activity;GO:0005549 odorant binding;GO:0099604 ligand-gated calcium channel activity;GO:0099094 ligand-gated monoatomic cation channel activity;GO:0170020 ionotropic olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032590 dendrite membrane", "go_biological_process": "GO:0098655 monoatomic cation transmembrane transport;GO:0070588 calcium ion transmembrane transport;GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VYZ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZD8-1", "uniprot_id": [ { "id": "THUM1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZD8", "type": "external" } ], "mass": 36207.0, "length": 324, "protein_name": "THUMP domain-containing protein 1 homolog", "gene_name": "CG15014", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_647892", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647892", "type": "external" } ], "gene_names_uniprotkb": "CG15014", "gene_names_refseq": "CG15014; Dmel\\CG15014", "protein_names_uniprotkb": "THUMP domain-containing protein 1 homolog", "protein_names_refseq": "CG15014-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG15014)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10731132;12537569;12537572;17372656;18327897", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "", "go_biological_process": "GO:0006400 tRNA modification", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9VZD8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZE5-1", "uniprot_id": [ { "id": "Q9VZE5_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZE5", "type": "external" } ], "mass": 15257.0, "length": 136, "protein_name": "Shrew", "gene_name": "srw", "organism": "Fruit fly", "refseq_name": "shrew", "refseq_ac": [ { "id": "NP_647886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647886", "type": "external" } ], "gene_names_uniprotkb": "srw; CG11582; Dmel\\CG11582; Dmel_CG11582", "gene_names_refseq": "CG11582; Dmel\\CG11582; srw", "protein_names_uniprotkb": "Shrew", "protein_names_refseq": "CG11582-PB; shrew; srw-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG11582)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0030513 positive regulation of BMP signaling pathway;GO:0009953 dorsal/ventral pattern formation;GO:0030510 regulation of BMP signaling pathway;GO:0007378 amnioserosa formation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VZE5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZI3-1", "uniprot_id": [ { "id": "UN112_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZI3", "type": "external" } ], "mass": 80497.0, "length": 708, "protein_name": "Unc-112-related protein", "gene_name": "Fit1", "organism": "Fruit fly", "refseq_name": "fermitin 1, isoform B", "refseq_ac": [ { "id": "NP_647858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647858", "type": "external" } ], "gene_names_uniprotkb": "Fit1; CG14991", "gene_names_refseq": "CG14991; Dmel\\CG14991; Fit 1; Fit1; anon-WO0118547.421; fit 1; fit1", "protein_names_uniprotkb": "Unc-112-related protein; Fermitin-1", "protein_names_refseq": "CG14991-PB; Fermitin1; Fit1-PB; fermitin 1, isoform B; fermitin 1", "tax_id": 7227, "disease": "Kindler syndrome (Disease Ontology:DOID:0060472); leukocyte adhesion deficiency 1 (Disease Ontology:DOID:0110910); leukocyte adhesion deficiency 3 (Disease Ontology:DOID:0110912); telangiectasis (Disease Ontology:DOID:1272); ovarian cancer (Disease Ontology:DOID:2394); vesiculobullous skin disease (Disease Ontology:DOID:2731); acute myeloid leukemia (Disease Ontology:DOID:9119)", "pathway": " (dme:Dmel_CG14991); (R-DME-114608); (R-DME-446353); (R-DME-9013149); (R-DME-9013423)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;18327897", "class_list": "", "function": "Probably involved in cell adhesion., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 7, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4V1G3;Q95SD2", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030055 cell-substrate junction", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0050829 defense response to Gram-negative bacterium;GO:0007160 cell-matrix adhesion;GO:0048738 cardiac muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9VZI3-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZL7-1", "uniprot_id": [ { "id": "GR63A_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZL7", "type": "external" } ], "mass": 57465.0, "length": 512, "protein_name": "Gustatory and odorant receptor 63a", "gene_name": "Gr63a", "organism": "Fruit fly", "refseq_name": "gustatory receptor 63a", "refseq_ac": [ { "id": "NP_001137883", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137883", "type": "external" } ], "gene_names_uniprotkb": "Gr63a; CG14979", "gene_names_refseq": "CG14979; DmGr63a; Dmel\\CG14979; GR63a; Gr63F1; Gr63a; gr63a", "protein_names_uniprotkb": "Gustatory and odorant receptor 63a", "protein_names_refseq": "CG14979-PB; Gr63a-PB; gustatory receptor 63F1; gustatory receptor 63a", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG14979)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10731132;11257221;11516643;12537572;17167414;17360684;17493811;19710651;23105004;23185459", "class_list": "", "function": "Gustatory and odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. Gr21a and Gr63a together are sufficient for carbon dioxide detection and avoidance behavior. It is possible that the CO(2) receptors Gr63a and Gr21a activate the TRPC channels through Galpha49B and Plc21C. This innate olfactory avoidance behavior can be inhibited by inhibitory interactions of the odors such as 1-hexanol and 2,3-butanedione with Gr21a and Gr63a., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A1C3K8;B7Z0B4", "ec_number_list": [], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0008527 taste receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007165 signal transduction;GO:0034220 monoatomic ion transmembrane transport;GO:0007608 sensory perception of smell;GO:0050909 sensory perception of taste;GO:0008340 determination of adult lifespan", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9VZL7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZN6-1", "uniprot_id": [ { "id": "Q9VZN6_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZN6", "type": "external" } ], "mass": 35156.0, "length": 321, "protein_name": "Lipase domain-containing protein", "gene_name": "Dmel\\CG10357", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_647821", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647821", "type": "external" } ], "gene_names_uniprotkb": "Dmel\\CG10357; CG10357; Dmel_CG10357", "gene_names_refseq": "CG10357; Dmel\\CG10357", "protein_names_uniprotkb": "Lipase domain-containing protein", "protein_names_refseq": "CG10357-PC; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG10357); (R-DME-192456); (R-DME-8963889); (R-DME-8964058)", "pathway_count": 4, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016298 lipase activity;GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9VZN6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9VZQ1-1", "uniprot_id": [ { "id": "YTDC1_DROME", "url": "https://www.uniprot.org/uniprot/Q9VZQ1", "type": "external" } ], "mass": 76259.0, "length": 721, "protein_name": "YTH domain-containing protein 1", "gene_name": "Ythdc1", "organism": "Fruit fly", "refseq_name": "YTH domain containing 1, isoform A", "refseq_ac": [ { "id": "NP_647811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647811", "type": "external" } ], "gene_names_uniprotkb": "Ythdc1; CG12076", "gene_names_refseq": "BcDNA:GH01918; CG12076; Dmel\\CG12076; YT521-B; YT521; Ythdc1; Ythdc; dYT521-B; ythdc", "protein_names_uniprotkb": "YTH domain-containing protein 1; Splicing factor YT521; YT521-B", "protein_names_refseq": "CG12076-PA; YT521-B; YTH domain containing 1, isoform A; Ythdc1-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12076); (R-DME-9930044)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;27919077;27919081;28675155", "class_list": "", "function": "Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:27919077, PubMed:27919081, PubMed:28675155). Acts by acting as a reader of m6A methylation (PubMed:27919077, PubMed:27919081). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy (PubMed:27919077, PubMed:27919081, PubMed:28675155). M6A methylation is also required for neuronal functions (PubMed:27919077)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8IH35;Q8IRD2;Q9Y172", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0003729 mRNA binding;GO:1990247 N6-methyladenosine-containing RNA reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0007530 sex determination;GO:0030154 cell differentiation;GO:0007548 sex differentiation;GO:0000398 mRNA splicing, via spliceosome;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9VZQ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W020-1", "uniprot_id": [ { "id": "NOM1_DROME", "url": "https://www.uniprot.org/uniprot/Q9W020", "type": "external" } ], "mass": 99116.0, "length": 854, "protein_name": "Nucleolar MIF4G domain-containing protein 1 homolog", "gene_name": "CG9004", "organism": "Fruit fly", "refseq_name": "uncharacterized protein", "refseq_ac": [ { "id": "NP_647717", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647717", "type": "external" } ], "gene_names_uniprotkb": "CG9004", "gene_names_refseq": "CG9004; Dmel\\CG9004", "protein_names_uniprotkb": "Nucleolar MIF4G domain-containing protein 1 homolog", "protein_names_refseq": "CG9004-PA; uncharacterized protein", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9004)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10731132;12537569;12537572", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9W020-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W060-1", "uniprot_id": [ { "id": "LYST_DROME", "url": "https://www.uniprot.org/uniprot/Q9W060", "type": "external" } ], "mass": 399853.0, "length": 3535, "protein_name": "Lysosomal-trafficking regulator", "gene_name": "mv", "organism": "Fruit fly", "refseq_name": "mauve", "refseq_ac": [ { "id": "NP_647681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_647681", "type": "external" } ], "gene_names_uniprotkb": "mv; CG11814; CG42863; CG5691", "gene_names_refseq": "CG11814; CG42863; CG5691; Dmel\\CG42863; fs(3)ros; mv; ros", "protein_names_uniprotkb": "Lysosomal-trafficking regulator; Mauve protein", "protein_names_refseq": "CG42863-PB; mauve; mv-PB; rosario", "tax_id": 7227, "disease": "exfoliation syndrome (Disease Ontology:DOID:13641); platelet storage pool deficiency (Disease Ontology:DOID:2223); Chediak-Higashi syndrome (Disease Ontology:DOID:2935)", "pathway": " (dme:Dmel_CG42863)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;22934826;33725482", "class_list": "", "function": "Adapter protein that regulates intracellular membrane fusion reactions (By similarity) (PubMed:33725482). Regulates the fusion of lysosome-related organelles (PubMed:33725482). Promotes microtubules nucleation and centrosomal recruitment of microtubule nucleating proteins such as msps (PubMed:33725482). In syncytial embryos, during the formation of yolk granules, suppresses vesicle fusion events with lipid droplets, possibly via interaction with Rab5 (PubMed:33725482). In the eye, regulates pigment granules size (PubMed:22934826). In hemocytes, required for the late steps of bacteria phagocytosis (PubMed:22934826). In fat body, required for autophagosome maturation (PubMed:22934826)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 3, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005819 spindle;GO:0005764 lysosome;GO:0031982 vesicle", "go_biological_process": "GO:0015031 protein transport;GO:0006909 phagocytosis;GO:0007040 lysosome organization;GO:0043473 pigmentation;GO:0090063 positive regulation of microtubule nucleation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9W060-1", "record_type": "protein", "filter_code": "0000000.0100111.001000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W074-1", "uniprot_id": [ { "id": "HBS1_DROME", "url": "https://www.uniprot.org/uniprot/Q9W074", "type": "external" } ], "mass": 74165.0, "length": 670, "protein_name": "Protein HBS1", "gene_name": "HBS1", "organism": "Fruit fly", "refseq_name": "HBS1, isoform B", "refseq_ac": [ { "id": "NP_001286906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286906", "type": "external" } ], "gene_names_uniprotkb": "HBS1; CG1898", "gene_names_refseq": "CG1898; Dmel\\CG1898; HBS1; Hbs1; hbs1", "protein_names_uniprotkb": "Protein HBS1; 3.6.5.-", "protein_names_refseq": "CG1898-PB; HBS1, isoform B; HBS1-PB", "tax_id": 7227, "disease": "beta thalassemia (Disease Ontology:DOID:12241)", "pathway": " (dme:Dmel_CG1898); (R-DME-429958); (R-DME-9954714)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10731132;12537572;26124316;30824860", "class_list": "", "function": "GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (By similarity). The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel (By similarity). Following ribosome-binding, the Pelota-HBS1L complex promotes recruitment of pix, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway (By similarity). Together with pelo, required for transposon silencing in the ovary and testis (PubMed:26124316). Together with pelo, promotes meiosis and spermatid individualization during spermatogenesis (PubMed:30824860)., [UniProtKB, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 1, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q86NR4", "ec_number_list": [ { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006417 regulation of translation;GO:0050829 defense response to Gram-negative bacterium;GO:0006412 translation;GO:0007291 sperm individualization;GO:0045089 positive regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9W074-1", "record_type": "protein", "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W0G6-1", "uniprot_id": [ { "id": "MSD5_DROME", "url": "https://www.uniprot.org/uniprot/Q9W0G6", "type": "external" } ], "mass": 28461.0, "length": 253, "protein_name": "Augmin complex subunit msd5", "gene_name": "msd5", "organism": "Fruit fly", "refseq_name": "mitotic spindle density 5", "refseq_ac": [ { "id": "NP_612101", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612101", "type": "external" } ], "gene_names_uniprotkb": "msd5; CG2213; dgt7", "gene_names_refseq": "CG2213; Dgt7; Dmel\\CG2213; Msd5; msd5", "protein_names_uniprotkb": "Augmin complex subunit msd5; Mitotic spindle density protein 5", "protein_names_refseq": "CG2213-PA; mitotic spindle density 5; msd5-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG2213)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537569;12537572;19369198", "class_list": "", "function": "As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005819 spindle;GO:0005874 microtubule;GO:0070652 HAUS complex", "go_biological_process": "GO:0010968 regulation of microtubule nucleation;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0007098 centrosome cycle;GO:0051225 spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9W0G6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W0G7-1", "uniprot_id": [ { "id": "MSD1_DROME", "url": "https://www.uniprot.org/uniprot/Q9W0G7", "type": "external" } ], "mass": 15669.0, "length": 138, "protein_name": "Augmin complex subunit msd1", "gene_name": "msd1", "organism": "Fruit fly", "refseq_name": "mitotic spindle density 1", "refseq_ac": [ { "id": "NP_612100", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612100", "type": "external" } ], "gene_names_uniprotkb": "msd1; CG13914; dgt9", "gene_names_refseq": "CG13914; Dgt9; Dmel\\CG13914; Msd1; msd1", "protein_names_uniprotkb": "Augmin complex subunit msd1; Mitotic spindle density protein 1", "protein_names_refseq": "CG13914-PA; mitotic spindle density 1; msd1-PA", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG13914)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10731132;12537572;19369198;19684111", "class_list": "", "function": "As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules. The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules. msd1 is required for microtubule nucleation from within the mitotic spindle and for localization of Grip71 to centrosomes and mitotic spindle., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6NMY7", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005819 spindle;GO:0005874 microtubule;GO:0070652 HAUS complex", "go_biological_process": "GO:0010968 regulation of microtubule nucleation;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0007020 microtubule nucleation;GO:0007098 centrosome cycle", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9W0G7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W0H3-1", "uniprot_id": [ { "id": "LDAH_DROME", "url": "https://www.uniprot.org/uniprot/Q9W0H3", "type": "external" } ], "mass": 35736.0, "length": 307, "protein_name": "Lipid droplet-associated hydrolase", "gene_name": "sturkopf", "organism": "Fruit fly", "refseq_name": "sturkopf, isoform B", "refseq_ac": [ { "id": "NP_612097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612097", "type": "external" } ], "gene_names_uniprotkb": "sturkopf; CG9186", "gene_names_refseq": "CG9186; Dmel\\CG9186; LDAH; Sturkopf; sturkopf", "protein_names_uniprotkb": "Lipid droplet-associated hydrolase; 3.1.1.13; Lipid droplet-associated serine hydrolase", "protein_names_refseq": "CG9186-PB; sturkopf, isoform B; sturkopf-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG9186)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10731132;12537569;12537572;23525007;27836991;30917324", "class_list": "", "function": "Probable serine lipid hydrolase associated with lipid droplets (By similarity). Appears to lack or have very low cholesterol esterase activity (By similarity) (PubMed:27836991). Appears to lack triglyceride lipase activity (PubMed:23525007, PubMed:27836991). Involved in cholesterol and triglyceride homeostasis; stimulates cellular triglyceride accumulation and cellular cholesterol release (By similarity). Involved in negatively regulating juvenile hormone (JH) and possibly, insulin signaling activities such as triacylglycerols (TAG) storage, and thereby plays a role in the endocrine regulation of organismal growth and survival (PubMed:30917324). Likely functions by enhancing the activity of the JH hydrolase enzymes Jheh1 and Jheh2 (PubMed:30917324). Required for lipid droplet positioning and fat storage (PubMed:23525007)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" } ], "go_molecular_function": "GO:0004771 sterol ester esterase activity;GO:0017171 serine hydrolase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0010883 regulation of lipid storage;GO:0034389 lipid droplet organization;GO:0030730 triglyceride storage;GO:0045928 negative regulation of juvenile hormone metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9W0H3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W0P3-1", "uniprot_id": [ { "id": "MED30_DROME", "url": "https://www.uniprot.org/uniprot/Q9W0P3", "type": "external" } ], "mass": 35301.0, "length": 318, "protein_name": "Mediator of RNA polymerase II transcription subunit 30", "gene_name": "MED30", "organism": "Fruit fly", "refseq_name": "mediator complex subunit 30", "refseq_ac": [ { "id": "NP_612046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612046", "type": "external" } ], "gene_names_uniprotkb": "MED30; CG17183; Trap25", "gene_names_refseq": "CG17183; Dmel\\CG17183; MED30; Med11/TRAP25; Med20; Med30; Trap25; dMED20; dTRAP25; med30", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 30; Mediator complex subunit 30; dMED20; dTRAP25", "protein_names_refseq": "CG17183-PA; MED30-PA; mediator complex subunit 30", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17183); (R-DME-9841922)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10731132;12021283;12537572", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9W0P3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W0P8-1", "uniprot_id": [ { "id": "MED14_DROME", "url": "https://www.uniprot.org/uniprot/Q9W0P8", "type": "external" } ], "mass": 172341.0, "length": 1553, "protein_name": "Mediator of RNA polymerase II transcription subunit 14", "gene_name": "MED14", "organism": "Fruit fly", "refseq_name": "mediator complex subunit 14, isoform A", "refseq_ac": [ { "id": "NP_612041", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612041", "type": "external" } ], "gene_names_uniprotkb": "MED14; CG12031; Trap170", "gene_names_refseq": "CG12031; Dmel\\CG12031; MED14; Med14; Trap170; dTRAP170; p160", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 14; Mediator complex subunit 14; dRGR1", "protein_names_refseq": "CG12031-PA; MED14-PA; mediator complex subunit 14, isoform A", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG12031); (R-DME-9841922)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "10731132;11259581;12537569;12537572;16751183;18327897", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5U1E1;Q8IRI9;Q961S0;Q9GYW6", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0060260 regulation of transcription initiation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9W0P8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000000100000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W0Q3-1", "uniprot_id": [ { "id": "Q9W0Q3_DROME", "url": "https://www.uniprot.org/uniprot/Q9W0Q3", "type": "external" } ], "mass": 32847.0, "length": 302, "protein_name": "BLOC-1 related complex subunit 6, isoform A; BLOC-1 related complex subunit 6, isoform B", "gene_name": "BORCS6", "organism": "Fruit fly", "refseq_name": "BLOC-1 related complex subunit 6, isoform B", "refseq_ac": [ { "id": "NP_001261214", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261214", "type": "external" } ], "gene_names_uniprotkb": "BORCS6; CG17180; Dmel\\CG17180; Dmel_CG17180", "gene_names_refseq": "BORCS6; CG17180; Dmel\\CG17180", "protein_names_uniprotkb": "BLOC-1 related complex subunit 6, isoform A; BLOC-1 related complex subunit 6, isoform B", "protein_names_refseq": "BLOC-1 related complex subunit 6, isoform B; BORCS6-PB; CG17180-PB", "tax_id": 7227, "disease": "", "pathway": " (dme:Dmel_CG17180)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "10731132;12537568;12537572;12537573;12537574;16110336;17569856;17569867;25589440;26109356;26109357", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098574 cytoplasmic side of lysosomal membrane;GO:0099078 BORC complex", "go_biological_process": "GO:0032418 lysosome localization;GO:0072384 organelle transport along microtubule", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q9W0Q3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000000100000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W0S3-1", "uniprot_id": [ { "id": "TI50B_DROME", "url": "https://www.uniprot.org/uniprot/Q9W0S3", "type": "external" } ], "mass": 47706.0, "length": 409, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM50-B", "gene_name": "ttm2", "organism": "Fruit fly", "refseq_name": "tiny tim 2", "refseq_ac": [ { "id": "NP_612023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612023", "type": "external" } ], "gene_names_uniprotkb": "ttm2; 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