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        "function": "Seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha. Might therefore contribute to the lack of inflammatory reaction seen during infection in spite the of extensive necrosis and massive virus production. Does not seem to be involved in activation of primary macrophages. Does not seem to interact specifically with neutrophils., [UniProtKB, PubMed, PubMed, PubMed]; Viroporin that permeabilizes mammalian cell plasma membranes. It acts by altering permeation of ionic compounds and small molecules. This activity may lead to viral enterotoxic activity., [UniProtKB, PubMed, PubMed]",
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        "go_molecular_function": "GO:0015267 channel activity",
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        ],
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        "protein_names_uniprotkb": "Polymerase cofactor VP35; Ebola VP35; eVP35",
        "protein_names_refseq": "polymerase complex protein",
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        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 34,
        "publication_id_list": "10073695;11027311;11062045;12191476;12829834;15464838;16095644;16495261;16698994;16698997;17065211;19122151;19153231;19403681;19557165;20071589;20081868;23493393;23870315;24067086;24495995;25741013;25865894;26962215;28794491;30482729;31562565;31694758;35533195;39293445;40164610;8237108;8482365;9971816",
        "class_list": "",
        "function": "Plays an essential role in viral RNA synthesis and also a role in suppressing innate immune signaling (PubMed:11027311, PubMed:35533195). Acts as a polymerase cofactor in the RNA polymerase transcription and replication complexes (PubMed:16495261, PubMed:24495995, PubMed:9971816). Serves as nucleoprotein/NP monomer chaperone prior to the formation of the large oligomeric RNA-bound complexes (By similarity). Part of the external layer of the nucleocapsid, likely tethering the nucleocapsid to the matrix and membrane (PubMed:39293445). Regulates RNA synthesis by modulating NP-RNA interactions and interacting with DYNLL1 (PubMed:25741013). VP35-NP interaction controls the switch between RNA-bound NP and free NP and thus the switch between genome replication and genome packaging into the nucleocapsid (PubMed:25865894). Prevents establishment of cellular antiviral state, thereby suppressing host DC maturation (PubMed:26962215). Acts by inhibiting host RIGI activation both by shielding dsRNA from detection and by preventing PRKRA binding to RIGI (PubMed:23870315). Blocks virus-induced phosphorylation and activation of interferon regulatory factor 3/IRF3, a transcription factor critical for the induction of interferons alpha and beta (PubMed:12829834). This blockage is produced through the interaction with and inhibition of host IKBKE and TBK1, producing a strong inhibition of the phosphorylation and activation of IRF3 (PubMed:12829834). Also inhibits the antiviral effect mediated by the host interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (PubMed:17065211). Increases PIAS1-mediated SUMOylation of IRF7, thereby repressing interferon transcription (PubMed:19557165). Also acts as a suppressor of RNA silencing by interacting with host DICER1, TARBP2/TRBP and PRKRA/PACT (By similarity). As a dimer, binds and sequesters dsRNA contributing to the inhibition of interferon production (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 8,
        "reported_mutagensis": 15,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q77LU7;Q8JS63",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0140313 molecular sequestering activity",
        "go_cellular_component": "GO:0019013 viral nucleocapsid;GO:0030430 host cell cytoplasm",
        "go_biological_process": "GO:0060965 negative regulation of miRNA-mediated gene silencing;GO:0006351 DNA-templated transcription;GO:0010629 negative regulation of gene expression;GO:0019083 viral transcription;GO:0019079 viral genome replication",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q05127-1",
        "record_type": "protein",
        "filter_code": "0000000.0100100.100000.000001000000000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q05128-1",
        "uniprot_id": [
            {
                "id": "VP40_EBOZM",
                "url": "https://www.uniprot.org/uniprot/Q05128",
                "type": "external"
            }
        ],
        "mass": 35183.0,
        "length": 326,
        "protein_name": "Matrix protein VP40",
        "gene_name": "VP40",
        "organism": "Ebola (EBOV)",
        "refseq_name": "matrix protein",
        "refseq_ac": [
            {
                "id": "NP_066245",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066245",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "VP40",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Matrix protein VP40; Ebola VP40; Membrane-associated protein VP40; eVP40",
        "protein_names_refseq": "matrix protein",
        "tax_id": 128952,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 32,
        "publication_id_list": "10073695;11062045;11095724;11118208;12559917;12679020;12919741;15650213;15892969;15908231;16051823;16698994;16719918;17229682;17699576;21987757;23637409;23953110;25159197;25786915;26753796;27489272;27849047;27872619;28177658;28768865;29339477;29950600;30205953;33673144;8237108;8482365",
        "class_list": "",
        "function": "Plays an essential role virus particle assembly and budding (PubMed:16719918, PubMed:33673144). Acts by interacting with viral ribonucleocapsid and host members of the ESCRT (endosomal sorting complex required for transport) system such as host VPS4, PDCD6IP/ALIX, NEDD4 or TGS101 (PubMed:15892969, PubMed:16719918, PubMed:23637409, PubMed:25786915, PubMed:26753796, PubMed:27489272). The interaction with host E3 ubiquitin ligase SMURF2 also facilitates virus budding (PubMed:33673144). May play a role in immune cell dysfunction by being packaged into exosomes that can decrease the viability of recipient cells (via RNAi suppression and exosome-bystander apoptosis) (PubMed:27872619)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 16,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0039660 structural constituent of virion",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0043657 host cell;GO:0045121 membrane raft;GO:1990904 ribonucleoprotein complex;GO:0055036 virion membrane",
        "go_biological_process": "GO:0039702 viral budding via host ESCRT complex;GO:0075733 intracellular transport of virus;GO:0046755 viral budding;GO:0046761 viral budding from plasma membrane;GO:0140533 symbiont-mediated suppression of host RNAi-mediated antiviral immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "Q05128-1",
        "record_type": "protein",
        "filter_code": "0000000.0100100.100000.000001000000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q05318-1",
        "uniprot_id": [
            {
                "id": "L_EBOZM",
                "url": "https://www.uniprot.org/uniprot/Q05318",
                "type": "external"
            }
        ],
        "mass": 252724.0,
        "length": 2212,
        "protein_name": "RNA-directed RNA polymerase L",
        "gene_name": "L",
        "organism": "Ebola (EBOV)",
        "refseq_name": "RNA-dependent RNA polymerase",
        "refseq_ac": [
            {
                "id": "NP_066251",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066251",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "L",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "RNA-directed RNA polymerase L; G-N7-MTase; Large structural protein; N1-2'-O-MTase; PRNTase; Protein L; Replicase; Transcriptase; mRNA (guanine-N(7)-)-methyltransferase; mRNA (nucleoside-2'-O-)-methyltransferase",
        "protein_names_refseq": "RNA-dependent RNA polymerase",
        "tax_id": 128952,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 6,
        "publication_id_list": "10073695;23582637;28991917;29507309;40164610;8237108",
        "class_list": "",
        "function": "RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymerase binds to the genomic RNA at the 3' leader promoter, and transcribes subsequently all viral mRNAs with a decreasing efficiency. The first gene is the most transcribed, and the last the least transcribed. The viral phosphoprotein acts as a processivity factor. Capping is concomitant with initiation of mRNA transcription. Indeed, a GDP polyribonucleotidyl transferase (PRNTase) adds the cap structure when the nascent RNA chain length has reached few nucleotides. Ribose 2'-O methylation of viral mRNA cap precedes and facilitates subsequent guanine-N-7 methylation, both activities being carried by the viral polymerase. Polyadenylation of mRNAs occur by a stuttering mechanism at a slipery stop site present at the end viral genes. After finishing transcription of a mRNA, the polymerase can resume transcription of the downstream gene., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O39794;Q773N0;Q8JS59;Q9DQD1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003968 RNA-directed RNA polymerase activity;GO:0003924 GTPase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity",
        "go_cellular_component": "GO:0044423 virion component;GO:0030430 host cell cytoplasm",
        "go_biological_process": "GO:0039689 negative stranded viral RNA replication;GO:0039697 negative stranded viral RNA transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q05318-1",
        "record_type": "protein",
        "filter_code": "0000000.0100100.010000.000001000000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q05320-1",
        "uniprot_id": [
            {
                "id": "VGP_EBOZM",
                "url": "https://www.uniprot.org/uniprot/Q05320",
                "type": "external"
            }
        ],
        "mass": 74464.0,
        "length": 676,
        "protein_name": "Envelope glycoprotein",
        "gene_name": "GP",
        "organism": "Ebola (EBOV)",
        "refseq_name": "spike glycoprotein",
        "refseq_ac": [
            {
                "id": "NP_066246",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066246",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GP",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Envelope glycoprotein; GP1,2-delta; GP1,2; GP",
        "protein_names_refseq": "spike glycoprotein",
        "tax_id": 128952,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 50,
        "publication_id_list": "35927436;10077567;10482652;10932225;11024148;11062045;11112476;11152533;11461707;11836430;11877482;12050398;12438572;12504546;1299611;14645601;14990712;15103332;15596847;15681442;15831716;16051836;16571833;16595665;16603527;16775318;18005986;19846529;20202662;21866103;22031933;25412102;26092855;26516900;26984723;27707924;28542576;28878074;29669839;30013549;30085081;32040508;35303429;8237108;8553543;8622982;9499027;9576958;9614872;9882347",
        "class_list": "",
        "function": "Acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in GP2, releasing the fusion hydrophobic peptide., [UniProtKB]; Functions as a decoy for anti-GP1,2 antibodies thereby contributing to viral immune evasion. Interacts and activates host macrophages and dendritic cells inducing up-regulation of cytokine transcription. This effect is mediated throught activation of host TLR4., [UniProtKB, PubMed, PubMed, PubMed]; Responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into dendritic cells (DCs) and endothelial cells (PubMed:16051836). Binding to the macrophage specific lectin CLEC10A also seems to enhance virus infectivity (By similarity). Interaction with FOLR1/folate receptor alpha may be a cofactor for virus entry in some cell types, although results are contradictory. Members of the Tyro3 receptor tyrosine kinase family also seem to be cell entry factors in filovirus infection (By similarity). Once attached, the virions are internalized through clathrin-dependent endocytosis and/or macropinocytosis. After internalization of the virus into the endosomes of the host cell, proteolysis of GP1 by two cysteine proteases, CTSB/cathepsin B and CTSL/cathepsin L removes the glycan cap and allows GP1 binding to the host entry receptor NPC1 (PubMed:21866103, PubMed:32040508). NPC1-binding, Ca(2+) and acidic pH induce a conformational change of GP2, which unmasks its fusion peptide and permit membranes fusion (PubMed:21866103, PubMed:22031933, PubMed:32040508)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; Trimeric GP1,2 complexes form the virion surface spikes and mediate the viral entry processes, with GP1 acting as the receptor-binding subunit and GP2 as the membrane fusion subunit. At later times of infection, down-regulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion (PubMed:11836430). Down-modulates several integrins including ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGAV and ITGB1 (PubMed:11112476). This decrease in cell adhesion molecules may lead to cell detachment, contributing to the disruption of blood vessel integrity and hemorrhages developed during infection (cytotoxicity) (Probable). Interacts with host TLR4 and thereby stimulates the differentiation and activation of monocytes leading to bystander death of T-lymphocytes (PubMed:28542576). Down-regulates as well the function of host natural killer cells (PubMed:30013549). Counteracts the antiviral effect of host BST2/tetherin that restricts release of progeny virions from infected cells (PubMed:26516900, PubMed:27707924, PubMed:29669839). However, cooperates with VP40 and host BST2 to activate canonical NF-kappa-B pathway in a manner dependent on neddylation (PubMed:28878074)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 17,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 17,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 17,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 17,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 76,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 8409,
        "biomarker_type": "",
        "glycan_count": 93,
        "disease_count": 0,
        "glyco_site_count": 17,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q66818;Q77LU5;Q8B9S1;Q8JS62",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0008289 lipid binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0045121 membrane raft;GO:0019031 viral envelope;GO:0055036 virion membrane;GO:0030430 host cell cytoplasm",
        "go_biological_process": "GO:0046718 symbiont entry into host cell;GO:0046761 viral budding from plasma membrane;GO:0039587 symbiont-mediated-mediated suppression of host tetherin activity;GO:0039654 fusion of virus membrane with host endosome membrane;GO:0075512 clathrin-dependent endocytosis of virus by host cell",
        "synthesized_glycan_count": 0,
        "hit_score": 16.1,
        "record_id": "Q05320-1",
        "record_type": "protein",
        "filter_code": "0000000.0100100.100000.000001000000000000.1000000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q05322-1",
        "uniprot_id": [
            {
                "id": "VP24_EBOZM",
                "url": "https://www.uniprot.org/uniprot/Q05322",
                "type": "external"
            }
        ],
        "mass": 28219.0,
        "length": 251,
        "protein_name": "Membrane-associated protein VP24",
        "gene_name": "VP24",
        "organism": "Ebola (EBOV)",
        "refseq_name": "membrane-associated protein",
        "refseq_ac": [
            {
                "id": "NP_066250",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066250",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "VP24",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Membrane-associated protein VP24; Ebola VP24; eVP24",
        "protein_names_refseq": "membrane-associated protein",
        "tax_id": 128952,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 13,
        "publication_id_list": "10073695;11062045;12191476;12525613;15220407;16698996;17928350;22383882;24630991;25121748;28794491;29144446;8237108",
        "class_list": "",
        "function": "Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1 by interacting with the STAT1-binding region of host importins. Alternatively also interacts directly with host STAT1 and may additionally inhibit its non-phosphorylated form. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q773N1;Q8JS60;Q9DQD2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005198 structural molecule activity",
        "go_cellular_component": "GO:0016020 membrane;GO:0055036 virion membrane;GO:0020002 host cell plasma membrane;GO:0033645 host cell endomembrane system",
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        ],
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                "id": "NP_066249",
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        "refseq_name": "alicorn, isoform A",
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        "protein_names_refseq": "CG8057-PA; alc-PA; alicorn, isoform A; beta homologue; beta subunit of the SNF1/AMP-activated protein kinase; lethal (2) 45Ad",
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        "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0006886 intracellular protein transport;GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport;GO:0070863 positive regulation of protein exit from endoplasmic reticulum",
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    },
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            {
                "id": "A1Z875_DROME",
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            }
        ],
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        "protein_name": "Odorant-binding protein 46a",
        "gene_name": "Obp46a",
        "organism": "Fruit fly",
        "refseq_name": "Odorant-binding protein 46a",
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            {
                "id": "NP_610574",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610574",
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            }
        ],
        "gene_names_uniprotkb": "Obp46a; CG12905; DmelObp46a; Dmel\\CG12905; Dmel_CG12905",
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        "protein_names_refseq": "CG12905-PA; Obp46a-PA; Odorant-binding protein 46a",
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    },
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            {
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        ],
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            {
                "id": "NP_610584",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_610584",
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            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG12896; BEST:LD11278; CG12896; Dmel_CG12896; Prx12896; RE05501p; RH54193",
        "gene_names_refseq": "BEST:LD11278; CG12896; Dmel\\CG12896; Prx12896; RE05501p; RH54193",
        "protein_names_uniprotkb": "1-Cys peroxiredoxin",
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        "function": "Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides., [UniProtKB, UniProtKB]",
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        ],
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                "id": "NP_001286290",
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        ],
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        "protein_names_refseq": "CG12934-PB; uncharacterized protein, isoform B",
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        ],
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        "disease": "hereditary systemic amyloidosis 1 (Disease Ontology:DOID:0050638); colorectal adenoma (Disease Ontology:DOID:0050860); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); carpal tunnel syndrome 1 (Disease Ontology:DOID:0070466); dystransthyretinemic hyperthyroxinemia (Disease Ontology:DOID:0080219); stomach cancer (Disease Ontology:DOID:10534); Alzheimer's disease (Disease Ontology:DOID:10652); lung cancer (Disease Ontology:DOID:1324); hyperuricemia (Disease Ontology:DOID:1920); brain ischemia (Disease Ontology:DOID:2316); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cholangiocarcinoma (Disease Ontology:DOID:4947); hepatocellular carcinoma (Disease Ontology:DOID:684); amyloidosis (Disease Ontology:DOID:9120); colorectal cancer (Disease Ontology:DOID:9256)",
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                "id": "NP_610765",
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        "protein_name": "Glial lazarillo, isoform A; Glial lazarillo, isoform B; Glial lazarillo, isoform C; Glial lazarillo, isoform D; Glial lazarillo, isoform E; Glial lazarillo, isoform F",
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        "protein_names_refseq": "CG4604-PB; GLaz-PB; glial lazarillo, isoform B; glial lazarillo",
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        "protein_names_refseq": "CG10799-PA; uncharacterized protein",
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            }
        ],
        "mass": 64509.0,
        "length": 579,
        "protein_name": "Carboxylic ester hydrolase",
        "gene_name": "Jhe",
        "organism": "Fruit fly",
        "refseq_name": "juvenile hormone esterase, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001163166",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163166",
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            }
        ],
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        "gene_names_refseq": "CG8425; DmJhe; Dmel\\CG8425; JHE; JH; Jhe; jhe",
        "protein_names_uniprotkb": "Carboxylic ester hydrolase; 3.1.1.-",
        "protein_names_refseq": "CG8425-PB; JH esterase; JH-esterase; Jhe-PB; juvenile hormone esterase, isoform B; juvenile hormone esterase",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG8425);  (R-DME-2022377);  (R-DME-211945);  (R-DME-5578768);  (R-DME-8964038);  (R-DME-9749641)",
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                "id": "3.1.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.1",
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            },
            {
                "id": "3.1.1.-",
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            }
        ],
        "go_molecular_function": "GO:0004453 juvenile-hormone esterase activity;GO:0106435 carboxylesterase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005739 mitochondrion",
        "go_biological_process": "GO:0060179 male mating behavior;GO:0048149 behavioral response to ethanol;GO:0006719 juvenile hormone catabolic process",
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        ],
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        "protein_name": "Uncharacterized protein",
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        "refseq_name": "uncharacterized protein, isoform B",
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            {
                "id": "NP_001027422",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027422",
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            }
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        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "ATP synthase coupling factor B; CG10731-PB; uncharacterized protein, isoform B",
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            {
                "id": "KRIMP_DROME",
                "url": "https://www.uniprot.org/uniprot/A1ZAC4",
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        ],
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        "length": 746,
        "protein_name": "Tudor domain-containing protein krimp",
        "gene_name": "krimp",
        "organism": "Fruit fly",
        "refseq_name": "krimper",
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            {
                "id": "NP_611103",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611103",
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            }
        ],
        "gene_names_uniprotkb": "krimp; CG15707; mtc",
        "gene_names_refseq": "CG15707; Dmel\\CG15707; KRIMP; Krimper; Krimp; krimp; mtc",
        "protein_names_uniprotkb": "Tudor domain-containing protein krimp; Protein krimper",
        "protein_names_refseq": "CG15707-PA; krimp-PA; krimper; montecristo",
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        "function": "Stable structural component of the perinuclear meiotic nuage, a germline-specific subcellular membraneless ribonucleoprotein compartment involved in production of transposable element-repressing Piwi-interacting RNA (piRNA)-induced silencing complexes (piRISCs), which are essential for maintaining germline integrity during oogenesis (PubMed:17428915, PubMed:26212455, PubMed:26295961). Scaffold component of the ping-pong piRNA processing (4P) complex that recruits the Piwi proteins aub and AGO3 to specific subregions of the nuage where it coordinates their activity in the ping-pong amplification step of secondary piRNA biogenesis (PubMed:26295961, PubMed:34210982). Binds methylated aub, which is associated with piRNA, and unmethylated AGO3, which is not associated with piRNA, bringing the Piwi proteins into close proximity and facilitating the loading of freshly cut piRNAs generated by aub onto AGO3 (PubMed:34210982). Promotes asymmetric ping-pong amplification by aub and AGO3 to bias production towards antisense piRNAs capable of silencing transposable elements (PubMed:26212455). Required for symmetrical dimethylation of AGO3, probably by recruitment to the nuage where methylosome components are located; dimethylation promotes AGO3 dissociation and interaction with other tudor-domain containing proteins such as tud (PubMed:26212455). Required for the recruitment of mael to the perinuclear meiotic nuage (PubMed:17428915). Required for the recruitment of aub to the nuage in testes but not in ovaries (PubMed:22303351). Involved in repression of long interspersed nuclear elements (LINEs) including HeT-A, I-element LINEs and possibly mst40, but not TART LINEs (PubMed:17428915)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]",
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            }
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        "protein_names_refseq": "CG8060-PA; uncharacterized protein",
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        "class_list": "",
        "function": "Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
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        "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism",
        "go_cellular_component": "GO:0016020 membrane;GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain",
        "go_biological_process": "GO:0007035 vacuolar acidification;GO:1902600 proton transmembrane transport",
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    },
    {
        "uniprot_canonical_ac": "A1ZAN6-1",
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            {
                "id": "A1ZAN6_DROME",
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            }
        ],
        "mass": 280808.0,
        "length": 2559,
        "protein_name": "Rho guanine nucleotide exchange factor 2, isoform D; Rho guanine nucleotide exchange factor 2, isoform F",
        "gene_name": "RhoGEF2",
        "organism": "Fruit fly",
        "refseq_name": "Rho guanine nucleotide exchange factor 2, isoform D",
        "refseq_ac": [
            {
                "id": "NP_477317",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477317",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RhoGEF2; CG9635; DRhoGEF2; DRhoGEF; Dmel\\CG9635; Dmel_CG9635; DrhoGEF2; Gef2; RG2; Rho-GEF2; RhoGEF; RhoGF2; RhoGef2; Su(Rho1)2B; T2; dRhoGEF2; dRhoGEF; l(2)04291; rhoGEF2; rhogef2; shar",
        "gene_names_refseq": "CG9635; DRhoGEF2; DRhoGEF; Dmel\\CG9635; DrhoGEF2; Gef2; RG2; Rho-GEF2; RhoGEF2; RhoGEF; RhoGF2; RhoGef2; Su(Rho1)2B; T2; dRhoGEF2; dRhoGEF; l(2)04291; rhoGEF2; rhogef2; shar",
        "protein_names_uniprotkb": "Rho guanine nucleotide exchange factor 2, isoform D; Rho guanine nucleotide exchange factor 2, isoform F",
        "protein_names_refseq": "CG9635-PD; Rho guanine nucleotide exchange factor 2, isoform D; RhoGEF2-PD; akkordion; guanine nucleotide exchange factor 2; shar pei; transcription unit 2",
        "tax_id": 7227,
        "disease": "immunodeficiency 62 (Disease Ontology:DOID:0111991)",
        "pathway": " (dme:Dmel_CG9635);  (R-DME-193648);  (R-DME-416482);  (R-DME-416572);  (R-DME-8980692);  (R-DME-9013148);  (R-DME-9013149)",
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        "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0045179 apical cortex;GO:0005737 cytoplasm;GO:0045177 apical part of cell;GO:0045178 basal part of cell;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0007015 actin filament organization;GO:0007186 G protein-coupled receptor signaling pathway;GO:0030036 actin cytoskeleton organization;GO:0009611 response to wounding",
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    },
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        "uniprot_canonical_ac": "A1ZAW3-1",
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            {
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        ],
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        "protein_name": "Rho GTPase activating protein at 54D, isoform A; Rho GTPase activating protein at 54D, isoform C",
        "gene_name": "RhoGAP54D",
        "organism": "Fruit fly",
        "refseq_name": "Rho GTPase activating protein at 54D, isoform C",
        "refseq_ac": [
            {
                "id": "NP_001261060",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001261060",
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            }
        ],
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        "gene_names_refseq": "CG6477; Dmel\\CG6477; RhoGAP54D",
        "protein_names_uniprotkb": "Rho GTPase activating protein at 54D, isoform A; Rho GTPase activating protein at 54D, isoform C",
        "protein_names_refseq": "CG6477-PC; Rho GTPase activating protein at 54D, isoform C; RhoGAP54D-PC",
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        "go_molecular_function": "GO:0005096 GTPase activator activity",
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        "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction;GO:0007264 small GTPase-mediated signal transduction;GO:0007480 imaginal disc-derived leg morphogenesis",
        "synthesized_glycan_count": 0,
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    {
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            {
                "id": "A1ZB08_DROME",
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            }
        ],
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        "length": 197,
        "protein_name": "MORN repeat-containing protein 3",
        "gene_name": "Dmel\\CG14490",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_611274",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611274",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG14490; CG14490; Dmel_CG14490",
        "gene_names_refseq": "CG14490; Dmel\\CG14490",
        "protein_names_uniprotkb": "MORN repeat-containing protein 3",
        "protein_names_refseq": "CG14490-PA; uncharacterized protein",
        "tax_id": 7227,
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        "pathway": " (dme:Dmel_CG14490)",
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        "class_list": "",
        "function": "Assembles a suppression complex (suppresome) by tethering SIRT1 and MDM2 to regulate composite modifications of p53/TP53. Confers both deacetylation-mediated functional inactivation, by SIRT1, and ubiquitination-dependent degradation, by MDM2, of p53/TP53, promoting a proliferative and cell survival behaviors. May play a role in the regulation of spermatogenesis., [UniProtKB, UniProtKB]",
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        ],
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        "protein_name": "C-type lectin domain-containing protein",
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        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
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            {
                "id": "NP_611309",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611309",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG14500; CG14500; Dmel_CG14500",
        "gene_names_refseq": "CG14500; Dmel\\CG14500",
        "protein_names_uniprotkb": "C-type lectin domain-containing protein",
        "protein_names_refseq": "CG14500-PA; uncharacterized protein",
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        "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0038187 pattern recognition receptor activity",
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        ],
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        "length": 154,
        "protein_name": "Bomanin bicipital 2, isoform A; Bomanin bicipital 2, isoform B",
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            {
                "id": "NP_001163193",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163193",
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            }
        ],
        "gene_names_uniprotkb": "BomBc2; Bom067; CG15067; Dmel\\CG15067; Dmel_CG15067; anon-EST:Posey85",
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        "protein_names_uniprotkb": "Bomanin bicipital 2, isoform A; Bomanin bicipital 2, isoform B",
        "protein_names_refseq": "BomBc2-PB; CG15067-PB; bomanin 067; bomanin Bc2; bomanin bicipital 2, isoform B",
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        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0045087 innate immune response",
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        ],
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        "protein_name": "2.5.1.18; Glutathione S transferase E8, isoform A; Glutathione S transferase E8, isoform B",
        "gene_name": "GstE8",
        "organism": "Fruit fly",
        "refseq_name": "glutathione S transferase E8, isoform B",
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        "gene_names_refseq": "BcDNA:GM08326; CG17533; DmGSTE8; Dmel\\CG17533; GST3-2; GSTE8; Gst3-2; GstE8; gste8",
        "protein_names_uniprotkb": "2.5.1.18; Glutathione S transferase E8, isoform A; Glutathione S transferase E8, isoform B",
        "protein_names_refseq": "CG17533-PB; Glutathione-S-transferase E8; GstE8-PB; glutathione S transferase E8, isoform B",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG17533)",
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        "publication_count": 11,
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        "function": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004364 glutathione transferase activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006749 glutathione metabolic process",
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        "hit_score": 1.2,
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        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A1ZB84-1",
        "uniprot_id": [
            {
                "id": "A1ZB84_DROME",
                "url": "https://www.uniprot.org/uniprot/A1ZB84",
                "type": "external"
            }
        ],
        "mass": 121330.0,
        "length": 1077,
        "protein_name": "GPI ethanolamine phosphate transferase 3, catalytic subunit",
        "gene_name": "PIG-O",
        "organism": "Fruit fly",
        "refseq_name": "phosphatidylinositol glycan anchor biosynthesis class O",
        "refseq_ac": [
            {
                "id": "NP_611332",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_611332",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PIG-O; CG12263; DmPIG-O; Dmel\\CG12263; Dmel_CG12263; PIGO; anon-WO0140519.205",
        "gene_names_refseq": "CG12263; DmPIG-O; Dmel\\CG12263; PIG-O; PIGO; anon-WO0140519.205",
        "protein_names_uniprotkb": "GPI ethanolamine phosphate transferase 3, catalytic subunit; Phosphatidylinositol-glycan biosynthesis class O protein",
        "protein_names_refseq": "CG12263-PA; PIG-O-PA; phosphatidylinositol glycan anchor biosynthesis class O",
        "tax_id": 7227,
        "disease": "hyperphosphatasia with impaired intellectual development syndrome 2 (Disease Ontology:DOID:0070434)",
        "pathway": " (dme:Dmel_CG12263)",
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        "class_list": "",
        "function": "Catalytic subunit of the ethanolamine phosphate transferase 3 complex that transfers an ethanolamine phosphate (EtNP) from a phosphatidylethanolamine (PE) to the 6-OH position of the third alpha-1,2-linked mannose of the a 2-acyl-6-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H6) intermediate to generate a a 2-acyl-6-[6-phosphoethanolamine-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H7) and participates in the tenth step of the glycosylphosphatidylinositol-anchor biosynthesis., [UniProtKB, UniProtKB]",
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        "biomarker_type": "",
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        "ec_number_list": [],
        "go_molecular_function": "GO:0051377 mannose-ethanolamine phosphotransferase activity",
        "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane",
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    },
    {
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            {
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            }
        ],
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            {
                "id": "NP_611349",
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            }
        ],
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        ],
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        ],
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        ],
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        ],
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        "protein_name": "2-oxoglutarate dehydrogenase, mitochondrial",
        "gene_name": "Ogdh1",
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                "id": "NP_001097629",
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        "protein_names_uniprotkb": "2-oxoglutarate dehydrogenase, mitochondrial; 1.2.4.2; 2-oxoglutarate dehydrogenase complex component E1; Alpha-ketoglutarate dehydrogenase",
        "protein_names_refseq": "CG11661-PI; Ogdh-PI; alpha-ketoglutarate dehydrogenase E1 subunit; at 73EF; neural conserved at 73EF; neural conserved at 73KF; neural conserved; oxoglutarate dehydrogenase, isoform I",
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        "disease": "Yoon-Bellen neurodevelopmental syndrome (Disease Ontology:DOID:0070468); oxoglutarate dehydrogenase deficiency (Disease Ontology:DOID:0081326); dilated cardiomyopathy (Disease Ontology:DOID:12930)",
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        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
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        "disease_count": 1,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z077",
        "ec_number_list": [
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "3.4.19.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-",
                "type": "external"
            },
            {
                "id": "5.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.5",
                "type": "external"
            },
            {
                "id": "2.4.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-",
                "type": "external"
            },
            {
                "id": "2.4.2.30",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0072572 poly-ADP-D-ribose binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016055 Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "B7Z078-1",
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        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "B7Z0E2-1",
        "uniprot_id": [
            {
                "id": "UNR_DROME",
                "url": "https://www.uniprot.org/uniprot/B7Z0E2",
                "type": "external"
            }
        ],
        "mass": 116560.0,
        "length": 1039,
        "protein_name": "RNA-binding protein Unr",
        "gene_name": "Unr",
        "organism": "Fruit fly",
        "refseq_name": "upstream of N-ras, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001137912",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137912",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Unr; CG7015",
        "gene_names_refseq": "BcDNA:LD13080; CG7015; CR32028; Dmel\\CG7015; MRE30; UNR; Unr; dUNR; dUnr; dunr; unr",
        "protein_names_uniprotkb": "RNA-binding protein Unr; Protein upstream of N-ras homolog",
        "protein_names_refseq": "CG7015-PB; Unr-PB; upstream of N-ras, isoform B; upstream of N-ras",
        "tax_id": 7227,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041)",
        "pathway": " (dme:Dmel_CG7015)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "10731132;12537569;12537572;16452508;16452509;18203923;19168682;19941818;25158899;25209665;32697992;36688322",
        "class_list": "",
        "function": "RNA-binding protein that acts as a regulator of dosage compensation in both males and females (PubMed:16452508, PubMed:16452509, PubMed:18203923, PubMed:19168682, PubMed:19941818, PubMed:25158899). In males, acts as positive regulator of dosage compensation by promoting assembly of the MSL complex, a multiprotein complex that mediates X-chromosome dosage compensation (PubMed:19168682, PubMed:25158899). Promotes MSL complex assembly via association with roX1 and roX2 non-coding RNA components of the MSL complex, facilitating the interaction between non-coding RNAs and mle (PubMed:19168682, PubMed:25158899). In females, acts as an inhibitor of dosage compensation together with Sxl by preventing production of msl-2 protein, an essential component of the MSL complex (PubMed:16452508, PubMed:16452509, PubMed:18203923, PubMed:19941818). Specifically binds to the 3'-UTR of msl-2 transcripts, and cooperates with Sxl to prevent translation initiation of msl-2 transcripts (PubMed:16452508, PubMed:16452509, PubMed:18203923, PubMed:19941818). Mechanistically, Sxl and Unr inhibit translation initiation by preventing ribosome recruitment after pAbp-mediated recruitment of the eIF4F complex (PubMed:19941818)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
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        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "M9ND61;Q960S8;Q9VSK3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:1905172 RISC complex binding;GO:0003723 RNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0140517 protein-RNA adaptor activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0070937 CRD-mediated mRNA stability complex;GO:0106002 mCRD-mediated mRNA stability complex",
        "go_biological_process": "GO:0070934 CRD-mediated mRNA stabilization;GO:0030154 cell differentiation;GO:0045947 negative regulation of translational initiation;GO:0007548 sex differentiation;GO:0042714 dosage compensation complex assembly",
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        "hit_score": 1.3,
        "record_id": "B7Z0E2-1",
        "record_type": "protein",
        "filter_code": "0000000.0100111.010000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
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            {
                "id": "B7Z0I2_DROME",
                "url": "https://www.uniprot.org/uniprot/B7Z0I2",
                "type": "external"
            }
        ],
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        "length": 1267,
        "protein_name": "SESTD1-like spectrin repeats region domain-containing protein",
        "gene_name": "Dmel\\CG15822",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform G",
        "refseq_ac": [
            {
                "id": "NP_001137872",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137872",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG15822; CG15822; Dmel_CG15822",
        "gene_names_refseq": "CG15822; Dmel\\CG15822",
        "protein_names_uniprotkb": "SESTD1-like spectrin repeats region domain-containing protein",
        "protein_names_refseq": "CG15822-PG; uncharacterized protein, isoform G",
        "tax_id": 7227,
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        "ec_number_list": [],
        "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding",
        "go_cellular_component": "",
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        "record_id": "B7Z0I2-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.010000.000000100000000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "B7Z0N9-1",
        "uniprot_id": [
            {
                "id": "B7Z0N9_DROME",
                "url": "https://www.uniprot.org/uniprot/B7Z0N9",
                "type": "external"
            }
        ],
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        "length": 217,
        "protein_name": "Uncharacterized protein",
        "gene_name": "Tes87",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_001138096",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138096",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Tes87; BEST:LP09246; BcDNA:LP09246; CG13414; CG31178; CT32770; Dmel\\CG31178; Dmel_CG31178",
        "gene_names_refseq": "BEST:LP09246; BcDNA:LP09246; CG13414; CG31178; CT32770; Dmel\\CG31178; Dromel_CG31178_FBtr0084138_mORF; Tes87",
        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG31178-PB; uncharacterized protein",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG31178)",
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        "publication_count": 11,
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                "id": "E1JGK3_DROME",
                "url": "https://www.uniprot.org/uniprot/E1JGK3",
                "type": "external"
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        ],
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        "protein_name": "Uncharacterized protein",
        "gene_name": "Dmel\\CG4984",
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        "refseq_name": "uncharacterized protein, isoform C",
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            {
                "id": "NP_001163182",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163182",
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            }
        ],
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        "gene_names_refseq": "CG4984; Dmel\\CG4984",
        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG4984-PC; uncharacterized protein, isoform C",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG4984)",
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        ],
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        "length": 1577,
        "protein_name": "2.7.10.1; PDGF- and VEGF-receptor related, isoform J",
        "gene_name": "Pvr",
        "organism": "Fruit fly",
        "refseq_name": "PDGF- and VEGF-receptor related, isoform J",
        "refseq_ac": [
            {
                "id": "NP_001162911",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162911",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Pvr; 8222; CG8222; CT24332; DmVEGFR; Dmel\\CG8222; Dmel_CG8222; PVR; PvR; VEGFR-A; VEGFR; VGR1; Vegfr-b; Vegfr-c; Vegfr; Vegf; Vgr1; pvr; stai; vgr1",
        "gene_names_refseq": "8222; CG8222; CT24332; DmVEGFR; Dmel\\CG8222; PVR; PvR; Pvr; VEGFR-A; VEGFR; VGR1; Vegfr-b; Vegfr-c; Vegfr; Vegf; Vgr1; pvr; stai; vgr1",
        "protein_names_uniprotkb": "2.7.10.1; PDGF- and VEGF-receptor related, isoform J",
        "protein_names_refseq": "CG8222-PJ; PDGF receptor; PDGF- and VEGF receptor related; PDGF- and VEGF- receptor related; PDGF- and VEGF-Receptor related; PDGF- and VEGF-receptor related, isoform J; PDGF- and VEGF-related receptor; PDGF/VEGF receptor; PVF receptor; Pvr-PJ; VEGF receptor; platelet-derived growth factor/vascular endothelial growth factor receptor; stasis; vascular endothelial growth factor receptor-1 like; vascular endothelial growth factor receptor",
        "tax_id": 7227,
        "disease": "pterygium (Disease Ontology:DOID:0002116); hereditary lymphedema (Disease Ontology:DOID:0050580); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); oral squamous cell carcinoma (Disease Ontology:DOID:0050866); medulloblastoma (Disease Ontology:DOID:0050902); salivary gland carcinoma (Disease Ontology:DOID:0050904); stroke (Disease Ontology:DOID:0051061); ductal carcinoma in situ (Disease Ontology:DOID:0060074); brain glioma (Disease Ontology:DOID:0060108); colitis (Disease Ontology:DOID:0060180); atrial fibrillation (Disease Ontology:DOID:0060224); basal ganglia calcification (Disease Ontology:DOID:0060230); cerebral cavernous malformation (Disease Ontology:DOID:0060669); arteriovenous malformations of the brain (Disease Ontology:DOID:0060688); hereditary lymphedema IA (Disease Ontology:DOID:0070210); infantile myofibromatosis 1 (Disease Ontology:DOID:0070666); colorectal carcinoma (Disease Ontology:DOID:0080199); adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (Disease Ontology:DOID:0080523); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); acute myelomonocytic leukemia (Disease Ontology:DOID:0081082); prostate cancer (Disease Ontology:DOID:10283); Hirschsprung's disease (Disease Ontology:DOID:10487); stomach cancer (Disease Ontology:DOID:10534); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); urinary bladder cancer (Disease Ontology:DOID:11054); prostatic hypertrophy (Disease Ontology:DOID:11132); sarcoma (Disease Ontology:DOID:1115); corneal neovascularization (Disease Ontology:DOID:11382); sciatic neuropathy (Disease Ontology:DOID:11446); bronchopulmonary dysplasia (Disease Ontology:DOID:11650); oligohydramnios (Disease Ontology:DOID:12215); leukemia (Disease Ontology:DOID:1240); retinopathy of prematurity (Disease Ontology:DOID:13025); proliferative diabetic retinopathy (Disease Ontology:DOID:13207); background diabetic retinopathy (Disease Ontology:DOID:13208); lung cancer (Disease Ontology:DOID:1324); Kawasaki disease (Disease Ontology:DOID:13378); extrahepatic cholestasis (Disease Ontology:DOID:13619); adhesions of uterus (Disease Ontology:DOID:13812); lymphangioma (Disease Ontology:DOID:1475); limited scleroderma (Disease Ontology:DOID:1577); diffuse scleroderma (Disease Ontology:DOID:1580); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); impotence (Disease Ontology:DOID:1875); melanoma (Disease Ontology:DOID:1909); leiomyosarcoma (Disease Ontology:DOID:1967); nephroblastoma (Disease Ontology:DOID:2154); myeloproliferative neoplasm (Disease Ontology:DOID:2226); brain ischemia (Disease Ontology:DOID:2316); colon adenocarcinoma (Disease Ontology:DOID:234); arteriosclerosis (Disease Ontology:DOID:2349); prostate adenocarcinoma (Disease Ontology:DOID:2526); hemangiopericytoma (Disease Ontology:DOID:264); transitional cell carcinoma (Disease Ontology:DOID:2671); Leydig cell tumor (Disease Ontology:DOID:2696); asthma (Disease Ontology:DOID:2841); endometriosis (Disease Ontology:DOID:289); granulosa cell tumor (Disease Ontology:DOID:2999); invasive ductal carcinoma (Disease Ontology:DOID:3008); allergic contact dermatitis (Disease Ontology:DOID:3042); carcinoma (Disease Ontology:DOID:305); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); interstitial lung disease (Disease Ontology:DOID:3082); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); inverted papilloma (Disease Ontology:DOID:3179); neurilemmoma (Disease Ontology:DOID:3192); piebaldism (Disease Ontology:DOID:3263); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); breast carcinoma (Disease Ontology:DOID:3459); mastocytosis (Disease Ontology:DOID:350); middle cerebral artery infarction (Disease Ontology:DOID:3525); choriocarcinoma (Disease Ontology:DOID:3594); cervical squamous cell carcinoma (Disease Ontology:DOID:3744); pulmonary fibrosis (Disease Ontology:DOID:3770); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); craniopharyngioma (Disease Ontology:DOID:3840); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); thyroid gland carcinoma (Disease Ontology:DOID:3963); systemic scleroderma (Disease Ontology:DOID:418); brain stem glioma (Disease Ontology:DOID:4202); endometrial stromal sarcoma (Disease Ontology:DOID:4226); scimitar syndrome (Disease Ontology:DOID:4297); seminoma (Disease Ontology:DOID:4440); dysgerminoma (Disease Ontology:DOID:4441); macular degeneration (Disease Ontology:DOID:4448); macular retinal edema (Disease Ontology:DOID:4449); renal cell carcinoma (Disease Ontology:DOID:4450); breast angiosarcoma (Disease Ontology:DOID:4511); pancreatic carcinoma (Disease Ontology:DOID:4905); esophagus adenocarcinoma (Disease Ontology:DOID:4914); cholangiocarcinoma (Disease Ontology:DOID:4947); myelofibrosis (Disease Ontology:DOID:4971); liver cirrhosis (Disease Ontology:DOID:5082); oxyphilic adenoma (Disease Ontology:DOID:5389); lung small cell carcinoma (Disease Ontology:DOID:5409); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); myocardial infarction (Disease Ontology:DOID:5844); nephrolithiasis (Disease Ontology:DOID:585); uveal melanoma (Disease Ontology:DOID:6039); uterine carcinosarcoma (Disease Ontology:DOID:6171); hepatocellular carcinoma (Disease Ontology:DOID:684); retinal telangiectasia (Disease Ontology:DOID:7736); osteoarthritis (Disease Ontology:DOID:8398); chronic ulcer of skin (Disease Ontology:DOID:8549); ulcerative colitis (Disease Ontology:DOID:8577); prostate carcinoma in situ (Disease Ontology:DOID:8634); myeloid sarcoma (Disease Ontology:DOID:8683); myeloid leukemia (Disease Ontology:DOID:8692); decubitus ulcer (Disease Ontology:DOID:8717); in situ carcinoma (Disease Ontology:DOID:8719); vascular dementia (Disease Ontology:DOID:8725); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); cervix uteri carcinoma in situ (Disease Ontology:DOID:8991); acute myeloid leukemia (Disease Ontology:DOID:9119); gastrointestinal stromal tumor (Disease Ontology:DOID:9253); colorectal cancer (Disease Ontology:DOID:9256); nasopharynx carcinoma (Disease Ontology:DOID:9261); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); neurofibroma (Disease Ontology:DOID:962); acute lymphoblastic leukemia (Disease Ontology:DOID:9952); hypereosinophilic syndrome (Disease Ontology:DOID:999)",
        "pathway": " (dme:Dmel_CG8222);  (R-DME-109704);  (R-DME-1257604);  (R-DME-1433557);  (R-DME-1433559);  (R-DME-186763);  (R-DME-186797);  (R-DME-216083);  (R-DME-4420097);  (R-DME-5673001);  (R-DME-6811558);  (R-DME-9607240)",
        "pathway_count": 12,
        "publication_count": 11,
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        "class_list": "",
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 134,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "3.2.1.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.21",
                "type": "external"
            },
            {
                "id": "3.2.1.46",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.46",
                "type": "external"
            },
            {
                "id": "3.1.4.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0038085 vascular endothelial growth factor binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0016020 membrane",
        "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0016322 neuron remodeling;GO:0030335 positive regulation of cell migration;GO:0043066 negative regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "E1JHB7-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "E1JHK9-1",
        "uniprot_id": [
            {
                "id": "E1JHK9_DROME",
                "url": "https://www.uniprot.org/uniprot/E1JHK9",
                "type": "external"
            }
        ],
        "mass": 83477.0,
        "length": 746,
        "protein_name": "Coiled-coil domain-containing protein",
        "gene_name": "Dmel\\CG10283",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform C",
        "refseq_ac": [
            {
                "id": "NP_001163006",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163006",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG10283; CG10283; Dmel_CG10283",
        "gene_names_refseq": "CG10283; Dmel\\CG10283",
        "protein_names_uniprotkb": "Coiled-coil domain-containing protein",
        "protein_names_refseq": "CG10283-PC; uncharacterized protein, isoform C",
        "tax_id": 7227,
        "disease": "mantle cell lymphoma (Disease Ontology:DOID:0050746); autosomal dominant nonsyndromic deafness 44 (Disease Ontology:DOID:0110569)",
        "pathway": " (dme:Dmel_CG10283)",
        "pathway_count": 1,
        "publication_count": 11,
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        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding",
        "go_cellular_component": "GO:0005737 cytoplasm",
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        "record_id": "E1JHK9-1",
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        "kg_view_protein": true
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    {
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        "uniprot_id": [
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                "id": "E1JHL3_DROME",
                "url": "https://www.uniprot.org/uniprot/E1JHL3",
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        ],
        "mass": 55125.0,
        "length": 470,
        "protein_name": "Male-specific transcript 36Fb",
        "gene_name": "Mst36Fb",
        "organism": "Fruit fly",
        "refseq_name": "Male-specific transcript 36Fb",
        "refseq_ac": [
            {
                "id": "NP_001163010",
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            }
        ],
        "gene_names_uniprotkb": "Mst36Fb; CG15165; CG31791; CG42626; Dmel\\CG42626; Dmel_CG42626; mst36Fb",
        "gene_names_refseq": "CG15165; CG31791; CG42626; Dmel\\CG42626; Mst36Fb; mst36Fb",
        "protein_names_uniprotkb": "Male-specific transcript 36Fb",
        "protein_names_refseq": "CG42626-PB; Male-specific transcript 36Fb; Mst36Fb-PB",
        "tax_id": 7227,
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        "go_biological_process": "GO:0007283 spermatogenesis",
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                "type": "external"
            }
        ],
        "mass": 40817.0,
        "length": 351,
        "protein_name": "Cdc23 domain-containing protein",
        "gene_name": "CG31687-PA",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001163022",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163022",
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            }
        ],
        "gene_names_uniprotkb": "CG31687-PA; CG31687; Dmel\\CG31687; Dmel_CG31687",
        "gene_names_refseq": "CG31687-PA; CG31687; Dmel\\CG31687",
        "protein_names_uniprotkb": "Cdc23 domain-containing protein",
        "protein_names_refseq": "CG31687-PB; Cdc23-like; uncharacterized protein, isoform B",
        "tax_id": 7227,
        "disease": "infertility (Disease Ontology:DOID:5223)",
        "pathway": " (dme:Dmel_CG31687)",
        "pathway_count": 1,
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        "go_cellular_component": "GO:0005680 anaphase-promoting complex",
        "go_biological_process": "GO:0051301 cell division",
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        "hit_score": 1.2,
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        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
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        "uniprot_id": [
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                "id": "E1JHS5_DROME",
                "url": "https://www.uniprot.org/uniprot/E1JHS5",
                "type": "external"
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        ],
        "mass": 8462.0,
        "length": 73,
        "protein_name": "BPTI/Kunitz inhibitor domain-containing protein",
        "gene_name": "Dmel\\CG42465",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_001162864",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001162864",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG42465; CG42465; Dmel_CG42465",
        "gene_names_refseq": "CG42465; Dmel\\CG42465",
        "protein_names_uniprotkb": "BPTI/Kunitz inhibitor domain-containing protein",
        "protein_names_refseq": "CG42465-PA; uncharacterized protein",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG42465)",
        "pathway_count": 1,
        "publication_count": 11,
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            {
                "id": "NP_001261796",
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        "gene_names_refseq": "0024/05; 0641/17; CG11280; CT31487; Dmel\\CG11280; Tartan; Trn; anon-EST:fe2B1; trn",
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        "protein_names_refseq": "CG2278-PB; uncharacterized protein, isoform B",
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        "go_biological_process": "GO:0008057 eye pigment granule organization;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0046718 symbiont entry into host cell;GO:0016192 vesicle-mediated transport;GO:0009306 protein secretion",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
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        "gene_names_uniprotkb": "Etf-QO; CG12140; ETF:QO",
        "gene_names_refseq": "CG 12140; CG12140; Dmel\\CG12140; ETF:QO; ETFDH; ETFD; Etf-QO; EtfQ0; I; l(2)46Ca",
        "protein_names_uniprotkb": "Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; 1.5.5.1; ETF dehydrogenase; ETF-QO; ETF-ubiquinone oxidoreductase; Electron-transferring-flavoprotein dehydrogenase",
        "protein_names_refseq": "CG12140-PB; Etf-QO-PB; electron transfer flavoprotein-ubiquinone oxidoreductase, isoform B; electron transfer flavoprotein-ubiquinone oxidoreductase; electron transfer flavoprotein:ubiquinone oxidoreductase; group I; lethal (2) 46Ca",
        "tax_id": 7227,
        "disease": "multiple acyl-CoA dehydrogenase deficiency (Disease Ontology:DOID:0060358)",
        "pathway": " (dme:Dmel_CG12140);  (R-DME-611105)",
        "pathway_count": 2,
        "publication_count": 3,
        "publication_id_list": "10731132;12537572;22580358",
        "class_list": "",
        "function": "Links fatty acid beta-oxidation and amino acid catabolism to the respiratory chain by transferring electrons from the electron transfer flavoprotein (ETF) to ubiquinone., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "1.5.5.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.5.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0004174 electron-transferring-flavoprotein dehydrogenase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane",
        "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0022900 electron transport chain",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q7JWF1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7K332-1",
        "uniprot_id": [
            {
                "id": "MISO1_DROME",
                "url": "https://www.uniprot.org/uniprot/Q7K332",
                "type": "external"
            }
        ],
        "mass": 27611.0,
        "length": 239,
        "protein_name": "Mitochondrial inner membrane subdomain organizer",
        "gene_name": "MISO",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform C",
        "refseq_ac": [
            {
                "id": "NP_001163069",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001163069",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MISO; CG30159",
        "gene_names_refseq": "CG30159; CG3364; Dmel\\CG30159",
        "protein_names_uniprotkb": "Mitochondrial inner membrane subdomain organizer",
        "protein_names_refseq": "CG30159-PC; uncharacterized protein, isoform C",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG30159)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "10731132;12537569;12537572;41398051",
        "class_list": "",
        "function": "Plays a role in regulation of mitochondrial morphology by promoting mitochondrial fragmentation., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
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        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q7K332-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7KRS9-1",
        "uniprot_id": [
            {
                "id": "ZMYD8_DROME",
                "url": "https://www.uniprot.org/uniprot/Q7KRS9",
                "type": "external"
            }
        ],
        "mass": 181889.0,
        "length": 1664,
        "protein_name": "MYND-type zinc finger-containing chromatin reader Zmynd8",
        "gene_name": "Zmynd8",
        "organism": "Fruit fly",
        "refseq_name": "zinc finger MYND-type containing 8, isoform C",
        "refseq_ac": [
            {
                "id": "NP_651881",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_651881",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Zmynd8; CG1815",
        "gene_names_refseq": "CG1815; Dmel\\CG1815; Zmynd8; cg1815",
        "protein_names_uniprotkb": "MYND-type zinc finger-containing chromatin reader Zmynd8",
        "protein_names_refseq": "CG1815-PC; Zmynd8-PC; zinc finger MYND-type containing 8, isoform C",
        "tax_id": 7227,
        "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888)",
        "pathway": " (dme:Dmel_CG1815)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "10731132;12537572;35916866",
        "class_list": "",
        "function": "Chromatin reader that recognizes specific histone signatures to regulate transcription (By similarity). Plays a role in neuronal development (PubMed:35916866)., [UniProtKB, UniProtKB, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8IMG3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0140015 histone H3K14ac reader activity;GO:0140109 histone H3K4me1 reader activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q7KRS9-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.010000.000000100000000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7KRU8-1",
        "uniprot_id": [
            {
                "id": "FRIH_DROME",
                "url": "https://www.uniprot.org/uniprot/Q7KRU8",
                "type": "external"
            }
        ],
        "mass": 23146.0,
        "length": 205,
        "protein_name": "Ferritin heavy chain",
        "gene_name": "Fer1HCH",
        "organism": "Fruit fly",
        "refseq_name": "ferritin 1 heavy chain homologue, isoform A",
        "refseq_ac": [
            {
                "id": "NP_524873",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_524873",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Fer1HCH; 1HCH; BEST:LD36673; CG2216; Dmel\\CG2216; Dmel_CG2216; FER1HCH; FER1; Fe1HCH; Fer-L; Fer1HC; Fer1H; Fer1; FerHCH; HCH; T21; T9; fer1HCH; fer1hch; fer1; l(3)00451; l(3)j10B4",
        "gene_names_refseq": "1HCH; BEST:LD36673; CG2216; Dmel\\CG2216; FER1HCH; FER1; Fe1HCH; Fer-L; Fer1HCH; Fer1HC; Fer1H; Fer1; FerHCH; HCH; T21; T9; fer1HCH; fer1hch; fer1; l(3)00451; l(3)j10B4",
        "protein_names_uniprotkb": "Ferritin heavy chain; 1.16.3.1",
        "protein_names_refseq": "CG2216-PA; Fer1HCH-PA; Ferritin-Heavy; Ferritin-Light; Ferritin1; ferritin 1 heavy chain homologue, isoform A; ferritin 1 heavy chain homolog; ferritin 1 heavy chain; ferritin 1HCH; ferritin HCH; ferritin heavy chain; ferritin subunit 1; ferritin-1 heavy chain homolog",
        "tax_id": 7227,
        "disease": "congestive heart failure (Disease Ontology:DOID:6000); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (dme:Dmel_CG2216);  (R-DME-432722);  (R-DME-6798695);  (R-DME-917937)",
        "pathway_count": 4,
        "publication_count": 23,
        "publication_id_list": "10619605;10731132;11804801;12537568;12537569;12537572;12537573;12537574;16110336;17569856;17569867;17603097;22885802;23064556;23771129;25589440;26109356;26109357;26192321;29237257;31568497;9266686;9801172",
        "class_list": "",
        "function": "Stores iron in a soluble, non-toxic, readily available form (By similarity) (PubMed:23771129). Important for iron homeostasis (By similarity) (PubMed:23064556, PubMed:23771129). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity) (PubMed:17603097, PubMed:23771129). Ferritin is composed of a heavy (H) chain which is responsible for the oxidation and uptake of ferrous iron, and a light (L) chain which facilitates the nucleation of the ferrihydrite iron core (PubMed:23771129). Required for dietary iron absorption in the midgut (PubMed:23064556). Involved in tissue iron detoxification by exporting excess iron (PubMed:23064556). Functions as an antioxidant and protects the developing organs from cell-mediated ferroptosis (PubMed:31568497). Required for embryo and larval development (PubMed:26192321). Plays a role in blood cell (haemocyte) differentiation in the lymph gland at the larval stage (PubMed:29237257). May also store Zn(2+) and Mn(2+) and thus may play a role in zinc and manganese homeostasis (PubMed:23771129)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "H1UUD2;Q7KMQ5;Q8I0T0",
        "ec_number_list": [
            {
                "id": "2.4.1.186",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186",
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            {
                "id": "5.4.2.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7",
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            },
            {
                "id": "5.4.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.-",
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            {
                "id": "3.5.2.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.17",
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            {
                "id": "3.2.1.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17",
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            {
                "id": "3.2.1.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31",
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            {
                "id": "1.1.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42",
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                "id": "3.5.1.28",
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                "id": "3.2.1.14",
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                "id": "3.1.3.48",
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                "id": "2.7.11.13",
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            {
                "id": "3.4.22.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-",
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                "id": "3.6.4.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1",
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                "id": "2.3.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5",
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                "id": "3.2.1.-",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26",
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                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
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                "id": "2.7.1.1",
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                "id": "5.2.1.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8",
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            {
                "id": "3.4.19.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-",
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                "id": "1.11.1.24",
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        "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0030681 multimeric ribonuclease P complex;GO:0005634 nucleus;GO:0000172 ribonuclease MRP complex",
        "go_biological_process": "GO:0006396 RNA processing;GO:0008033 tRNA processing;GO:0006364 rRNA processing;GO:0001682 tRNA 5'-leader removal",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q7KVW2-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000100000000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
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            {
                "id": "Q7KW26_DROME",
                "url": "https://www.uniprot.org/uniprot/Q7KW26",
                "type": "external"
            }
        ],
        "mass": 31730.0,
        "length": 301,
        "protein_name": "Uncharacterized protein",
        "gene_name": "EG:34F3.10",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_569862",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569862",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EG:34F3.10; CG13358; Dmel\\CG13358; Dmel_CG13358",
        "gene_names_refseq": "CG13358; Dmel\\CG13358; EG:34F3.10",
        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG13358-PD; uncharacterized protein",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG13358)",
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    },
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        "uniprot_canonical_ac": "Q7PL72-1",
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            {
                "id": "Q7PL72_DROME",
                "url": "https://www.uniprot.org/uniprot/Q7PL72",
                "type": "external"
            }
        ],
        "mass": 20433.0,
        "length": 171,
        "protein_name": "Uncharacterized protein",
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        "refseq_name": "uncharacterized protein, isoform A",
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            {
                "id": "NP_001036404",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036404",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Dmel\\CG40439; CG40439; CG46302; Dmel\\CG46302; Dmel_CG40439; Dmel_CG46302",
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        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG40439-PA; uncharacterized protein, isoform A",
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        "disease": "",
        "pathway": " (dme:Dmel_CG40439);  (dme:Dmel_CG46302)",
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        "record_id": "Q7PL72-1",
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        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7PLE6-1",
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            {
                "id": "Q7PLE6_DROME",
                "url": "https://www.uniprot.org/uniprot/Q7PLE6",
                "type": "external"
            }
        ],
        "mass": 40266.0,
        "length": 364,
        "protein_name": "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial",
        "gene_name": "Bckdhb",
        "organism": "Fruit fly",
        "refseq_name": "branched chain keto acid dehydrogenase E1 subunit beta, isoform E",
        "refseq_ac": [
            {
                "id": "NP_001015354",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015354",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Bckdhb; BckdhB; CG17691; Dmel\\CG17691; Dmel_CG17691; bckdhB",
        "gene_names_refseq": "BckdhB; CG17691; Dmel\\CG17691; bckdhB",
        "protein_names_uniprotkb": "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial; 1.2.4.4; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain",
        "protein_names_refseq": "BckdhB-PE; CG17691-PE; branched chain keto acid dehydrogenase E1 subunit beta, isoform E; branched-chain a-keto acid dehydrogenase",
        "tax_id": 7227,
        "disease": "maple syrup urine disease type IB (Disease Ontology:DOID:0061206); maple syrup urine disease (Disease Ontology:DOID:9269)",
        "pathway": " (dme:Dmel_CG17691);  (R-DME-9859138)",
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        "class_list": "",
        "function": "Together with BCKDHA forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction., [UniProtKB, UniProtKB]",
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        "secondary_ac_list": "A8QHW9",
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            {
                "id": "1.2.4.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.4",
                "type": "external"
            },
            {
                "id": "1.8.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4",
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            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003863 branched-chain 2-oxo acid dehydrogenase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0160157 branched-chain alpha-ketoacid dehydrogenase complex",
        "go_biological_process": "GO:0007584 response to nutrient;GO:0009083 branched-chain amino acid catabolic process;GO:0006574 L-valine catabolic process;GO:0006552 L-leucine catabolic process;GO:0006550 L-isoleucine catabolic process",
        "synthesized_glycan_count": 0,
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7PLG1-1",
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            {
                "id": "Q7PLG1_DROME",
                "url": "https://www.uniprot.org/uniprot/Q7PLG1",
                "type": "external"
            }
        ],
        "mass": 91770.0,
        "length": 780,
        "protein_name": "DnaJ homolog subfamily C member 16",
        "gene_name": "l(3)80Fg",
        "organism": "Fruit fly",
        "refseq_name": "lethal (3) 80Fg, isoform A",
        "refseq_ac": [
            {
                "id": "NP_001015187",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015187",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "l(3)80Fg; 80Fg; CG40178; Dmel\\CG40178; Dmel_CG40178; l(3)Lh4A; l4A",
        "gene_names_refseq": "80Fg; CG40178; Dmel\\CG40178; l(3)80Fg; l(3)Lh4A; l4A",
        "protein_names_uniprotkb": "DnaJ homolog subfamily C member 16; Endoplasmic reticulum DNA J domain-containing protein 8",
        "protein_names_refseq": "CG40178-PA; l(3)80Fg-PA; lethal (3) 80Fg, isoform A; lethal 4A; lethal4A",
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        "disease": "",
        "pathway": " (dme:Dmel_CG40178)",
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        "function": "Plays an important role in regulating the size of autophagosomes during the formation process., [UniProtKB, UniProtKB]",
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        "secondary_ac_list": "Q5BII3",
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        "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006914 autophagy",
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        "record_id": "Q7PLG1-1",
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        "filter_code": "0000000.0000101.100000.000000100000000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7PLL3-1",
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            {
                "id": "Q7PLL3_DROME",
                "url": "https://www.uniprot.org/uniprot/Q7PLL3",
                "type": "external"
            }
        ],
        "mass": 52202.0,
        "length": 459,
        "protein_name": "Eukaryotic translation initiation factor 4B, isoform B",
        "gene_name": "eIF4B",
        "organism": "Fruit fly",
        "refseq_name": "eukaryotic translation initiation factor 4B, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001015319",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015319",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "eIF4B; CG10837; Dm-eIF4B; Dmel\\CG10837; Dmel_CG10837; EIF-4B; EIF4B; Eif4B; eIF-4B-L; eIF-4B-S; eIF-4B; eIF-4b; eIF4B-L; eIF4B-S; eIf4b",
        "gene_names_refseq": "CG10837; Dm-eIF4B; Dmel\\CG10837; EIF-4B; EIF4B; Eif4B; eIF-4B-L; eIF-4B-S; eIF-4B; eIF-4b; eIF4B-L; eIF4B-S; eIF4B; eIf4b",
        "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4B, isoform B",
        "protein_names_refseq": "CG10837-PB; eIF4B-PB; eukaryotic initiation factor 4B; eukaryotic translation initiation factor 4B, isoform B",
        "tax_id": 7227,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); major depressive disorder (Disease Ontology:DOID:1470)",
        "pathway": " (dme:Dmel_CG10837)",
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        "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity",
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        "record_id": "Q7PLL3-1",
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    },
    {
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        ],
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        "length": 177,
        "protein_name": "Uncharacterized protein",
        "gene_name": "Dmel\\CG33189",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_788599",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788599",
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            }
        ],
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        "gene_names_refseq": "CG33189; Dmel\\CG33189",
        "protein_names_uniprotkb": "Uncharacterized protein",
        "protein_names_refseq": "CG33189-PA; uncharacterized protein",
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        "pathway": " (dme:Dmel_CG33189)",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86BH3-1",
        "uniprot_id": [
            {
                "id": "Q86BH3_DROME",
                "url": "https://www.uniprot.org/uniprot/Q86BH3",
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        ],
        "mass": 23852.0,
        "length": 212,
        "protein_name": "2'-phosphotransferase",
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        "organism": "Fruit fly",
        "refseq_name": "tRNA 2'-phosphotransferase, isoform B",
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            {
                "id": "NP_001286980",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001286980",
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            }
        ],
        "gene_names_uniprotkb": "Tpt; CG33057; Dmel\\CG33057; Dmel_CG33057; Tpt1",
        "gene_names_refseq": "CG33057; Dmel\\CG33057; Tpt1; Tpt",
        "protein_names_uniprotkb": "2'-phosphotransferase; 2.7.1.160",
        "protein_names_refseq": "CG33057-PB; Tpt-PB; tRNA 2'-phosphotransferase, isoform B",
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        "class_list": "",
        "function": "Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate., [UniProtKB, UniProtKB]",
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            {
                "id": "2.7.1.160",
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            }
        ],
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    },
    {
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            {
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        ],
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        "length": 430,
        "protein_name": "Z band alternatively spliced PDZ-motif protein 66, isoform E",
        "gene_name": "Zasp66",
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        "refseq_name": "Z band alternatively spliced PDZ-motif protein 66, isoform E",
        "refseq_ac": [
            {
                "id": "NP_729395",
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                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Zasp66; CG6416; Dmel\\CG6416; Dmel_CG6416; ZASP66; Zaps66; anon-WO0153538.30",
        "gene_names_refseq": "CG6416; Dmel\\CG6416; ZASP66; Zaps66; Zasp66; anon-WO0153538.30",
        "protein_names_uniprotkb": "Z band alternatively spliced PDZ-motif protein 66, isoform E",
        "protein_names_refseq": "CG6416-PE; Z band alternatively spliced PDZ-motif protein 66, isoform E; Zasp66-PE",
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        "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0008157 protein phosphatase 1 binding;GO:0003779 actin binding",
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    },
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            {
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        ],
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            {
                "id": "NP_788522",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788522",
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            }
        ],
        "gene_names_uniprotkb": "Polr3G; CG33051; CG3882; Dmel\\CG33051; Dmel_CG33051; RPC31",
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        "protein_names_uniprotkb": "DNA-directed RNA polymerase III subunit",
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        "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs., [UniProtKB, UniProtKB]",
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        ],
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            {
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                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285922",
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        ],
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        "protein_names_uniprotkb": "Hemese, isoform B; Hemese, isoform C",
        "protein_names_refseq": "CG31770-PC; He-PC; gustav; hemese, isoform C; hemese; hemes",
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        "disease": "Netherton syndrome (Disease Ontology:DOID:0050474); late onset Parkinson's disease (Disease Ontology:DOID:0060892); Parkinsonism (Disease Ontology:DOID:0080855); Gaucher's disease type I (Disease Ontology:DOID:0110957); Gaucher's disease type II (Disease Ontology:DOID:0110958); Gaucher's disease type III (Disease Ontology:DOID:0110959); Gaucher's disease perinatal lethal (Disease Ontology:DOID:0110960); Gaucher's disease type IIIC (Disease Ontology:DOID:0112250); Lewy body dementia (Disease Ontology:DOID:12217); Parkinson's disease (Disease Ontology:DOID:14330); Gaucher's disease (Disease Ontology:DOID:1926); psoriasis (Disease Ontology:DOID:8893)",
        "pathway": " (dme:Dmel_CG31414);  (R-DME-9840310)",
        "pathway_count": 2,
        "publication_count": 11,
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        "class_list": "glycogene;glycosylhydrolase",
        "function": "",
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        "ec_number_list": [
            {
                "id": "3.2.1.45",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.45",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004348 glucosylceramidase activity;GO:0046527 glucosyltransferase activity",
        "go_cellular_component": "GO:0016020 membrane;GO:0005764 lysosome",
        "go_biological_process": "GO:0006680 glucosylceramide catabolic process;GO:0007613 memory;GO:0008344 adult locomotory behavior;GO:0070050 neuron cellular homeostasis;GO:0034620 cellular response to unfolded protein",
        "synthesized_glycan_count": 0,
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    },
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            {
                "id": "Q9VCN7_DROME",
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            }
        ],
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        "protein_name": "Oo18 RNA-binding protein, isoform A; Oo18 RNA-binding protein, isoform G",
        "gene_name": "orb",
        "organism": "Fruit fly",
        "refseq_name": "oo18 RNA-binding protein, isoform G",
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            {
                "id": "NP_001262870",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001262870",
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            }
        ],
        "gene_names_uniprotkb": "orb; 151666_s_at; CG10868; Dmel\\CG10868; Dmel_CG10868; ORB1; ORB; Oo18; Orb1; Orb; fs(3)00107; oo18",
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        "protein_names_uniprotkb": "Oo18 RNA-binding protein, isoform A; Oo18 RNA-binding protein, isoform G",
        "protein_names_refseq": "CG10868-PG; ORB; Oo18 RNA-binding protein; oo18 RNA binding protein; oo18 RNA binding; oo18 RNA-binding protein, isoform G; orb-PG",
        "tax_id": 7227,
        "disease": "portal hypertension (Disease Ontology:DOID:10762); primary biliary cholangitis (Disease Ontology:DOID:12236); glioblastoma (Disease Ontology:DOID:3068); liver cirrhosis (Disease Ontology:DOID:5082)",
        "pathway": "",
        "pathway_count": 0,
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        "go_cellular_component": "GO:0005737 cytoplasm;GO:1990904 ribonucleoprotein complex;GO:0005634 nucleus;GO:0005938 cell cortex;GO:0045202 synapse",
        "go_biological_process": "GO:0006397 mRNA processing;GO:0007281 germ cell development;GO:0007310 oocyte dorsal/ventral axis specification;GO:0007314 oocyte anterior/posterior axis specification;GO:0008069 dorsal/ventral axis specification, ovarian follicular epithelium",
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        ],
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        "protein_name": "GPR158/179 extracellular domain-containing protein",
        "gene_name": "Dmel\\CG31195",
        "organism": "Fruit fly",
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            {
                "id": "NP_732553",
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        ],
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            {
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        "function": "Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)., [UniProtKB, UniProtKB]",
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                "id": "NP_731135",
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    },
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            {
                "id": "Q8IPI3_DROME",
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            }
        ],
        "mass": 131604.0,
        "length": 1190,
        "protein_name": "Anion exchange protein",
        "gene_name": "Ndae1",
        "organism": "Fruit fly",
        "refseq_name": "Na[+]-driven anion exchanger 1, isoform C",
        "refseq_ac": [
            {
                "id": "NP_723263",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_723263",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Ndae1; 153385_at; CG31906; CG42253; CG4675; Dmel\\CG42253; Dmel_CG42253; NDAE1; Ndae-1; anon-WO0257455.13; l(2)k10316; ndae1",
        "gene_names_refseq": "153385_at; CG31906; CG42253; CG4675; Dmel\\CG42253; NDAE1; Ndae-1; Ndae1; anon-WO0257455.13; l(2)k10316; ndae1",
        "protein_names_uniprotkb": "Anion exchange protein",
        "protein_names_refseq": "CG42253-PC; Na[+]-driven anion exchanger 1, isoform C; Ndae1-PC",
        "tax_id": 7227,
        "disease": "proximal renal tubular acidosis-ocular anomaly syndrome (Disease Ontology:DOID:0061195); Usher syndrome type 2C (Disease Ontology:DOID:0110839); hypertension (Disease Ontology:DOID:10763); prediabetes syndrome (Disease Ontology:DOID:11716); nephrogenic diabetes insipidus (Disease Ontology:DOID:12387); renal tubular acidosis (Disease Ontology:DOID:14219); anemia (Disease Ontology:DOID:2355); cholangiocarcinoma (Disease Ontology:DOID:4947)",
        "pathway": " (dme:Dmel_CG42253);  (R-DME-425381);  (R-DME-9013406);  (R-DME-9013407);  (R-DME-9035034)",
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        "go_molecular_function": "GO:0008509 monoatomic anion transmembrane transporter activity;GO:0005452 solute:inorganic anion antiporter activity;GO:0008510 sodium:bicarbonate symporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane",
        "go_biological_process": "GO:0055085 transmembrane transport;GO:0015701 bicarbonate transport;GO:0051453 regulation of intracellular pH;GO:1902476 chloride transmembrane transport;GO:0035725 sodium ion transmembrane transport",
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    },
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                "id": "Q8IPI4_DROME",
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            }
        ],
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        "length": 424,
        "protein_name": "Male specific transcript 27D, isoform A; Male specific transcript 27D, isoform B",
        "gene_name": "Mst27D",
        "organism": "Fruit fly",
        "refseq_name": "male specific transcript 27D, isoform B",
        "refseq_ac": [
            {
                "id": "NP_001285705",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001285705",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Mst27D; CG31907; Dmel\\CG31907; Dmel_CG31907; NEST:bs06f02; NEST:bs25f07; NEST:bs29b10",
        "gene_names_refseq": "CG31907; Dmel\\CG31907; Mst27D; NEST:bs06f02; NEST:bs25f07; NEST:bs29b10",
        "protein_names_uniprotkb": "Male specific transcript 27D, isoform A; Male specific transcript 27D, isoform B",
        "protein_names_refseq": "CG31907-PB; Mst27D-PB; male specific transcript 27D, isoform B",
        "tax_id": 7227,
        "disease": "",
        "pathway": " (dme:Dmel_CG31907)",
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        "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0051225 spindle assembly;GO:0035372 protein localization to microtubule",
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    },
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            }
        ],
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        "protein_name": "Trichohyalin",
        "gene_name": "CG11005",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein",
        "refseq_ac": [
            {
                "id": "NP_730971",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_730971",
                "type": "external"
            }
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        "gene_names_uniprotkb": "CG11005; CG31551; Dmel\\CG31551; Dmel_CG31551",
        "gene_names_refseq": "CG11005; CG31551; Dmel\\CG31551",
        "protein_names_uniprotkb": "Trichohyalin",
        "protein_names_refseq": "CG31551-PA; uncharacterized protein",
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            }
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            }
        ],
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        "protein_name": "ADP-ribose glycohydrolase OARD1",
        "gene_name": "Targ1",
        "organism": "Fruit fly",
        "refseq_name": "terminal ADP-ribose protein glycohydrolase 1, isoform B",
        "refseq_ac": [
            {
                "id": "NP_788553",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788553",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "Targ1; CG10167; CG10517; CG33054; Dmel\\CG33054; Dmel_CG33054; dTarg1",
        "gene_names_refseq": "CG10167; CG10517; CG33054; Dmel\\CG33054; Targ1; dTarg1",
        "protein_names_uniprotkb": "ADP-ribose glycohydrolase OARD1; O-acetyl-ADP-ribose deacetylase 1; Terminal ADP-ribose protein glycohydrolase 1; [Protein ADP-ribosylglutamate] hydrolase OARD1",
        "protein_names_refseq": "CG33054-PB; Targ1-PB; terminal ADP-ribose protein glycohydrolase 1, isoform B",
        "tax_id": 7227,
        "disease": "",
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        "class_list": "",
        "function": "ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose. Specifically acts as a glutamate mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to glutamate residues on proteins. Does not act on poly-ADP-ribosylated proteins: the poly-ADP-ribose chain of poly-ADP-ribosylated glutamate residues must by hydrolyzed into mono-ADP-ribosylated glutamate by PARG to become a substrate for OARD1. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively., [UniProtKB, UniProtKB, UniProtKB]",
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        "go_molecular_function": "GO:0001883 purine nucleoside binding;GO:0140293 ADP-ribosylglutamate hydrolase activity;GO:0047407 ADP-ribosyl-[dinitrogen reductase] hydrolase activity;GO:0016787 hydrolase activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005694 chromosome",
        "go_biological_process": "GO:0006974 DNA damage response;GO:0042278 purine nucleoside metabolic process",
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        "protein_name": "ABC transporter domain-containing protein",
        "gene_name": "CK02656; Dmel\\CG3164",
        "organism": "Fruit fly",
        "refseq_name": "uncharacterized protein, isoform A",
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            {
                "id": "NP_722605",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_722605",
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        ],
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        "gene_names_refseq": "BEST:CK02656; CG3164; CK02656; DmCG3164; Dmel\\CG3164; l(2)21Ba",
        "protein_names_uniprotkb": "ABC transporter domain-containing protein",
        "protein_names_refseq": "CG3164-PA; lethal (2) 21Ba; uncharacterized protein, isoform A",
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        "disease": "end stage renal disease (Disease Ontology:DOID:783)",
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                "id": "5.3.1.6",
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        ],
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            {
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            {
                "id": "NP_726048",
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        "function": "A broad-specificity exonuclease, capable of degrading both structure-specific DNA and RNA targets without sequence specificity in vitro (PubMed:17135487). Requires two to five unpaired nucleotides in the 3' region for efficient binding and nuclease activity (PubMed:17135487). Binds with higher affinity to RNA and DNA stem-loop substrates compared to single-stranded substrate (PubMed:17135487). Binds to the 3'-end of histone mRNAs and degrades them, suggesting that it might play a role in histone mRNA decay after replication (PubMed:17135487). Can readily cleave the histone stem-loop RNA beyond the -12 (UUU) position in the loop to produce -14 and then -16 oligonucleotide fragments for both the stem-loop and the reverse stem-loop (PubMed:17135487). Cleaves both the single-stranded 3' flank as well as the double-stranded stem portion of histone stem-loop RNA (PubMed:17135487). Might affect histone mRNA 3' processing thereby regulating histone protein expression (PubMed:28626879). Has an important role in development and tissue formation (PubMed:28626879). Might have a role in 5.8S rRNA precursor processing (PubMed:28626879)., [UniProtKB, PubMed, PubMed]",
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        "go_biological_process": "GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0060906 negative regulation of regulatory ncRNA-mediated heterochromatin formation",
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        "protein_name": "BBSome complex member BBS5",
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        "gene_names_refseq": "BBS5; CG1126; Dmel\\CG1126",
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        "disease": "ciliopathy (Disease Ontology:DOID:0060340); Bardet-Biedl syndrome 5 (Disease Ontology:DOID:0110127); Bardet-Biedl syndrome (Disease Ontology:DOID:1935)",
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