[ { "uniprot_canonical_ac": "F1MTP5-1", "uniprot_id": [ { "id": "F1MTP5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MTP5", "type": "external" } ], "mass": 67917.0, "length": 623, "protein_name": "WD repeat-containing protein 1", "gene_name": "WDR1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "WDR1", "gene_names_refseq": "", "protein_names_uniprotkb": "WD repeat-containing protein 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-114608)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005911 cell-cell junction;GO:0030864 cortical actin cytoskeleton", "go_biological_process": "GO:0043297 apical junction assembly;GO:0042247 establishment of planar polarity of follicular epithelium;GO:0030834 regulation of actin filament depolymerization;GO:0002446 neutrophil mediated immunity;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MTP5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MTZ4-1", "uniprot_id": [ { "id": "F1MTZ4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MTZ4", "type": "external" } ], "mass": 314516.0, "length": 2912, "protein_name": "Fibrillin-2", "gene_name": "FBN2", "organism": "Bovine", "refseq_name": "fibrillin-2 precursor", "refseq_ac": [ { "id": "NP_001265517", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265517", "type": "external" } ], "gene_names_uniprotkb": "FBN2", "gene_names_refseq": "FBN2", "protein_names_uniprotkb": "Fibrillin-2", "protein_names_refseq": "fibrillin-2 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:540017); (R-BTA-1474228); (R-BTA-1566948); (R-BTA-2129379)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "15612324;19524133", "class_list": "", "function": "Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively., [UniProtKB, UniProtKB]; Hormone secreted by trophoblasts that promotes trophoblast invasiveness. Has glucogenic activity: is able to increase plasma glucose levels., [UniProtKB, UniProtKB]; Hormone that targets the liver to increase plasma glucose levels. Secreted by white adipose tissue and circulates in the plasma. Acts in response to fasting and promotes blood glucose elevation by binding to the surface of hepatocytes. Promotes hepatocyte glucose release by activating the protein kinase A activity in the liver, resulting in rapid glucose release into the circulation., [UniProtKB, UniProtKB, UniProtKB]; The coordinate upregulation of fibrillin-1 and fibrillin-2 expression with the onset of tropoelastin production is consistent with a role in elastic fiber assembly., [RefSeq, PubMed]; This is the first study to investigate the expression and localization of fibrillin proteins and latent TGF-beta binding proteins affecting TGFbeta bioavailability in the ovary., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005179 hormone activity;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0005576 extracellular region;GO:0001527 microfibril;GO:0031012 extracellular matrix", "go_biological_process": "GO:0009887 animal organ morphogenesis;GO:0048598 embryonic morphogenesis;GO:0042593 glucose homeostasis;GO:0006006 glucose metabolic process;GO:0048048 embryonic eye morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1MTZ4-1", "record_type": "protein", "filter_code": "0000000.0000101.001000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MWF6-1", "uniprot_id": [ { "id": "F1MWF6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MWF6", "type": "external" } ], "mass": 94759.0, "length": 851, "protein_name": "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein", "gene_name": "ACAP3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ACAP3", "gene_names_refseq": "", "protein_names_uniprotkb": "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein; Centaurin-beta; Cnt-b", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "GTPase-activating protein for the ADP ribosylation factor family., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0010008 endosome membrane;GO:0030426 growth cone", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MWF6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MW99-1", "uniprot_id": [ { "id": "F1MW99_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MW99", "type": "external" } ], "mass": 49568.0, "length": 446, "protein_name": "DNA repair protein RAD51 homolog 3", "gene_name": "RAD51C", "organism": "Bovine", "refseq_name": "DNA repair protein RAD51 homolog 3 isoform X2", "refseq_ac": [ { "id": "XP_059734376", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734376", "type": "external" } ], "gene_names_uniprotkb": "RAD51C", "gene_names_refseq": "RAD51C", "protein_names_uniprotkb": "DNA repair protein RAD51 homolog 3; RAD51 homolog C; RAD51-like protein 2", "protein_names_refseq": "DNA repair protein RAD51 homolog 3 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:540886); (R-BTA-5685942); (R-BTA-5693537); (R-BTA-5693568); (R-BTA-5693579); (R-BTA-5693616); (R-BTA-983231)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0140664 ATP-dependent DNA damage sensor activity;GO:0000400 four-way junction DNA binding;GO:0008821 crossover junction DNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0048471 perinuclear region of cytoplasm;GO:0043596 nuclear replication fork;GO:0033065 Rad51C-XRCC3 complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0000707 meiotic DNA recombinase assembly;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0007131 reciprocal meiotic recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MW99-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MNU5-1", "uniprot_id": [ { "id": "F1MNU5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MNU5", "type": "external" } ], "mass": 94348.0, "length": 845, "protein_name": "Phospholipase A2", "gene_name": "PLA2G4F", "organism": "Bovine", "refseq_name": "cytosolic phospholipase A2 zeta", "refseq_ac": [ { "id": "NP_001179498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179498", "type": "external" } ], "gene_names_uniprotkb": "PLA2G4F", "gene_names_refseq": "PLA2G4F", "protein_names_uniprotkb": "Phospholipase A2; 3.1.1.4", "protein_names_refseq": "cytosolic phospholipase A2 zeta", "tax_id": 9913, "disease": "", "pathway": " (bta:522866); (R-BTA-1482788); (R-BTA-1482801); (R-BTA-1482839); (R-BTA-1482922); (R-BTA-1482925); (R-BTA-1483115)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.149", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0004623 phospholipase A2 activity;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane;GO:0031982 vesicle;GO:0032587 ruffle membrane", "go_biological_process": "GO:0009395 phospholipid catabolic process;GO:0019370 leukotriene biosynthetic process;GO:0006071 glycerol metabolic process;GO:0001516 prostaglandin biosynthetic process;GO:0046475 glycerophospholipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MNU5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MY41-1", "uniprot_id": [ { "id": "F1MY41_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MY41", "type": "external" } ], "mass": 135642.0, "length": 1191, "protein_name": "Structural maintenance of chromosomes protein", "gene_name": "SMC2", "organism": "Bovine", "refseq_name": "structural maintenance of chromosomes protein 2", "refseq_ac": [ { "id": "XP_015328154", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015328154", "type": "external" } ], "gene_names_uniprotkb": "SMC2", "gene_names_refseq": "SMC2", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein", "protein_names_refseq": "structural maintenance of chromosomes protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:539217); (R-BTA-2299718); (R-BTA-2514853)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003682 chromatin binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0000228 nuclear chromosome;GO:0000794 condensed nuclear chromosome;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0051301 cell division;GO:0030261 chromosome condensation;GO:1905820 positive regulation of chromosome separation;GO:0051984 positive regulation of chromosome segregation;GO:0021987 cerebral cortex development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MY41-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MHF0-1", "uniprot_id": [ { "id": "F1MHF0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MHF0", "type": "external" } ], "mass": 103147.0, "length": 915, "protein_name": "E3 ubiquitin-protein ligase MARCHF6", "gene_name": "MARCHF6", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MARCHF6", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF6; 2.3.2.27; Membrane-associated RING finger protein 6; Membrane-associated RING-CH protein VI", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:1990381 ubiquitin-specific protease binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway;GO:0070936 protein K48-linked ubiquitination;GO:0045541 negative regulation of cholesterol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MHF0-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MWF8-1", "uniprot_id": [ { "id": "F1MWF8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MWF8", "type": "external" } ], "mass": 49478.0, "length": 453, "protein_name": "Replication stress response regulator SDE2", "gene_name": "SDE2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SDE2", "gene_names_refseq": "", "protein_names_uniprotkb": "Replication stress response regulator SDE2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-72163)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress. SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage., [UniProtKB, UniProtKB]; Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3'-splice sites (ss) and high GC content. May recruit CACTIN to the spliceosome., [UniProtKB, UniProtKB]; Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor. Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003684 damaged DNA binding;GO:0030515 snoRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016607 nuclear speck", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0016485 protein processing;GO:0051301 cell division;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MWF8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MUW6-1", "uniprot_id": [ { "id": "F1MUW6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MUW6", "type": "external" } ], "mass": 123351.0, "length": 1095, "protein_name": "TATA element modulatory factor 1", "gene_name": "TMF1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TMF1", "gene_names_refseq": "", "protein_names_uniprotkb": "TATA element modulatory factor 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-6811440)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0050681 nuclear androgen receptor binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030521 androgen receptor signaling pathway;GO:0061136 regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MUW6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MPG0-1", "uniprot_id": [ { "id": "F1MPG0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MPG0", "type": "external" } ], "mass": 84508.0, "length": 758, "protein_name": "DNA mismatch repair protein MLH1", "gene_name": "MLH1", "organism": "Bovine", "refseq_name": "DNA mismatch repair protein Mlh1", "refseq_ac": [ { "id": "NP_001069462", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069462", "type": "external" } ], "gene_names_uniprotkb": "MLH1", "gene_names_refseq": "MLH1", "protein_names_uniprotkb": "DNA mismatch repair protein MLH1; DNA mismatch repair protein Mlh1; MutL protein homolog 1", "protein_names_refseq": "DNA mismatch repair protein Mlh1; MutL protein homolog 1; mutL homolog 1, colon cancer, nonpolyposis type 2", "tax_id": 9913, "disease": "", "pathway": " (bta:533652); (R-BTA-5358565)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23673140", "class_list": "", "function": "Meiosis progression and female age affect expression profile of DNA repair MLH1 gene in bovine oocytes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0030983 mismatched DNA binding;GO:0140664 ATP-dependent DNA damage sensor activity;GO:0003682 chromatin binding", "go_cellular_component": "GO:0031981 nuclear lumen;GO:0005694 chromosome;GO:0032300 mismatch repair complex;GO:0005654 nucleoplasm;GO:0032389 MutLalpha complex", "go_biological_process": "GO:0006298 mismatch repair;GO:0000710 meiotic mismatch repair;GO:0016446 somatic hypermutation of immunoglobulin genes", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MPG0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MI47-1", "uniprot_id": [ { "id": "F1MI47_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MI47", "type": "external" } ], "mass": 69575.0, "length": 669, "protein_name": "RNA-binding protein 14", "gene_name": "RBM14", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RBM14", "gene_names_refseq": "", "protein_names_uniprotkb": "RNA-binding protein 14; RNA-binding motif protein 14", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-8941326)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003713 transcription coactivator activity;GO:0003729 mRNA binding;GO:1990935 splicing factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0010467 gene expression;GO:0098534 centriole assembly;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0002218 activation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MI47-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MU24-1", "uniprot_id": [ { "id": "F1MU24_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MU24", "type": "external" } ], "mass": 96339.0, "length": 843, "protein_name": "Alpha-1,4 glucan phosphorylase", "gene_name": "PYGB", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PYGB", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-1,4 glucan phosphorylase; 2.4.1.1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-6798695)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0008184 glycogen phosphorylase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0005977 glycogen metabolic process;GO:0005980 glycogen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MU24-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MLA4-1", "uniprot_id": [ { "id": "F1MLA4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MLA4", "type": "external" } ], "mass": 26644.0, "length": 245, "protein_name": "Dehydrogenase/reductase SDR family member 6", "gene_name": "BDH2", "organism": "Bovine", "refseq_name": "dehydrogenase/reductase SDR family member 6 isoform X2", "refseq_ac": [ { "id": "XP_024848971", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848971", "type": "external" } ], "gene_names_uniprotkb": "BDH2", "gene_names_refseq": "BDH2; DHRS6", "protein_names_uniprotkb": "Dehydrogenase/reductase SDR family member 6; (R)-beta-hydroxybutyrate dehydrogenase; 1.1.1.104; 1.1.1.30; 3-hydroxybutyrate dehydrogenase type 2; 4-oxo-L-proline reductase; Oxidoreductase UCPA; Short chain dehydrogenase/reductase family 15C member 1", "protein_names_refseq": "dehydrogenase/reductase SDR family member 6 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-77111)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates. Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines. Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis. May act as a 3-hydroxybutyrate dehydrogenase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.104", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.104", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0051287 NAD binding;GO:0003858 3-hydroxybutyrate dehydrogenase activity;GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor;GO:0016617 4-oxoproline reductase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0030855 epithelial cell differentiation;GO:0019290 siderophore biosynthetic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MLA4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MM08-1", "uniprot_id": [ { "id": "F1MM08_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MM08", "type": "external" } ], "mass": 42968.0, "length": 394, "protein_name": "Dual specificity protein phosphatase", "gene_name": "DUSP4", "organism": "Bovine", "refseq_name": "dual specificity protein phosphatase 4", "refseq_ac": [ { "id": "NP_001193882", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193882", "type": "external" } ], "gene_names_uniprotkb": "DUSP4", "gene_names_refseq": "DUSP4", "protein_names_uniprotkb": "Dual specificity protein phosphatase; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "dual specificity protein phosphatase 4", "tax_id": 9913, "disease": "", "pathway": " (bta:540380); (R-BTA-112409); (R-BTA-202670); (R-BTA-5675221)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0001706 endoderm formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MM08-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MV86-1", "uniprot_id": [ { "id": "F1MV86_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MV86", "type": "external" } ], "mass": 32466.0, "length": 292, "protein_name": "G1/S-specific cyclin-D3", "gene_name": "CCND3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CCND3", "gene_names_refseq": "", "protein_names_uniprotkb": "G1/S-specific cyclin-D3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5687128); (R-BTA-69231); (R-BTA-8934593); (R-BTA-9754119)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Shows transcriptional coactivator activity with ATF5 independently of CDK4., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity;GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005815 microtubule organizing center", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0051301 cell division;GO:0000082 G1/S transition of mitotic cell cycle;GO:1900087 positive regulation of G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MV86-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MY37-1", "uniprot_id": [ { "id": "F1MY37_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MY37", "type": "external" } ], "mass": 32847.0, "length": 313, "protein_name": "Zinc transporter ZIP9", "gene_name": "SLC39A9", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SLC39A9", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc transporter ZIP9; Solute carrier family 39 member 9; ZIP-9; Zrt- and Irt-like protein 9", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0004930 G protein-coupled receptor activity;GO:0005497 androgen binding;GO:0022883 zinc efflux transmembrane transporter activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006882 intracellular zinc ion homeostasis;GO:1905562 regulation of vascular endothelial cell proliferation;GO:2000654 regulation of cellular response to testosterone stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MY37-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MLD0-1", "uniprot_id": [ { "id": "F1MLD0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MLD0", "type": "external" } ], "mass": 90269.0, "length": 816, "protein_name": "4'-phosphopantetheine phosphatase", "gene_name": "PANK4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PANK4", "gene_names_refseq": "", "protein_names_uniprotkb": "4'-phosphopantetheine phosphatase; 3.1.3.-", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-199220)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0004594 pantothenate kinase activity;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0015937 coenzyme A biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MLD0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MMI3-1", "uniprot_id": [ { "id": "F1MMI3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MMI3", "type": "external" } ], "mass": 66423.0, "length": 599, "protein_name": "GATOR complex protein NPRL3", "gene_name": "NPRL3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NPRL3", "gene_names_refseq": "", "protein_names_uniprotkb": "GATOR complex protein NPRL3; Nitrogen permease regulator 3-like protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-9639288)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005764 lysosome;GO:1990130 GATOR1 complex;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0032007 negative regulation of TOR signaling;GO:0034198 cellular response to amino acid starvation;GO:0010508 positive regulation of autophagy;GO:1904262 negative regulation of TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MMI3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MTS8-1", "uniprot_id": [ { "id": "F1MTS8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MTS8", "type": "external" } ], "mass": 204184.0, "length": 1813, "protein_name": "E3 ubiquitin-protein ligase listerin", "gene_name": "LTN1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LTN1", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase listerin; 2.3.2.27; RING-type E3 ubiquitin transferase listerin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-983168); (R-BTA-9954709)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005829 cytosol;GO:1990112 RQC complex;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MTS8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MS46-1", "uniprot_id": [ { "id": "F1MS46_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MS46", "type": "external" } ], "mass": 40217.0, "length": 368, "protein_name": "CCN family member 4", "gene_name": "CCN4", "organism": "Bovine", "refseq_name": "CCN family member 4 isoform X1", "refseq_ac": [ { "id": "XP_005215377", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215377", "type": "external" } ], "gene_names_uniprotkb": "CCN4", "gene_names_refseq": "CCN4", "protein_names_uniprotkb": "CCN family member 4; WNT1-inducible-signaling pathway protein 1", "protein_names_refseq": "CCN family member 4 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:539163)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0016055 Wnt signaling pathway;GO:0045595 regulation of cell differentiation;GO:0051239 regulation of multicellular organismal process;GO:0030316 osteoclast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MS46-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MY54-1", "uniprot_id": [ { "id": "F1MY54_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MY54", "type": "external" } ], "mass": 133340.0, "length": 1205, "protein_name": "Nitric oxide synthase", "gene_name": "NOS3", "organism": "Bovine", "refseq_name": "nitric oxide synthase 3", "refseq_ac": [ { "id": "NP_851380", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851380", "type": "external" } ], "gene_names_uniprotkb": "NOS3", "gene_names_refseq": "EC-NOS; NOS3; NOSIII; cNOS; eNOS", "protein_names_uniprotkb": "Nitric oxide synthase; 1.14.13.39", "protein_names_refseq": "NOS type III; constitutive NOS; endothelial NOS; endothelial nitric oxide synthase; nitric oxide synthase 3 (endothelial cell); nitric oxide synthase 3; nitric oxide synthase, endothelial", "tax_id": 9913, "disease": "", "pathway": " (bta:287024); (R-BTA-1222556); (R-BTA-1474151); (R-BTA-203615); (R-BTA-203641); (R-BTA-203754); (R-BTA-392154); (R-BTA-5218920); (R-BTA-9009391); (R-BTA-9856530)", "pathway_count": 10, "publication_count": 5, "publication_id_list": "27073025;27613870;28320874;28684613;33168911", "class_list": "", "function": "Endothelial cell autophagy maintains shear stress-induced nitric oxide generation via glycolysis-dependent ATP/P2Y1 receptor signaling to endothelial nitric oxide synthase., [RefSeq, PubMed]; Produces nitric oxide (NO) which is a messenger molecule with diverse functions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Regulation of O-GlcNAcylation on endothelial nitric oxide synthase by glucose deprivation and identification of its O-GlcNAcylation sites. Publication Status: Online-Only, [RefSeq, PubMed]; S1179D substitution in eNOS increased the rate of flavin reduction, altered the conformational equilibrium of the reductase domain, and increased the rate of its conformational transitions., [RefSeq, PubMed]; TNFalpha reduces eNOS activity in bovine endothelial cells through serine 116 phosphorylation and Pin1 binding., [RefSeq, PubMed]; These data define the mechanism responsible for the repressive effects of nitric oxide (NO) on the transcriptional activity of beta-catenin and link eNOS-derived NO to the modulation by VEGF of Wnt/beta-catenin-induced endothelial cell proliferation. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" } ], "go_molecular_function": "GO:0004517 nitric-oxide synthase activity;GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005856 cytoskeleton;GO:0005901 caveola;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006809 nitric oxide biosynthetic process;GO:0032496 response to lipopolysaccharide;GO:0045766 positive regulation of angiogenesis;GO:0045776 negative regulation of blood pressure;GO:0007263 nitric oxide mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "F1MY54-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MXG0-1", "uniprot_id": [ { "id": "F1MXG0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MXG0", "type": "external" } ], "mass": 80174.0, "length": 700, "protein_name": "Histone-lysine N-methyltransferase SETDB2", "gene_name": "SETDB2", "organism": "Bovine", "refseq_name": "histone-lysine N-methyltransferase SETDB2", "refseq_ac": [ { "id": "NP_001137333", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137333", "type": "external" } ], "gene_names_uniprotkb": "SETDB2", "gene_names_refseq": "SETDB2", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SETDB2; 2.1.1.366; SET domain bifurcated 2", "protein_names_refseq": "SET domain bifurcated 2; histone-lysine N-methyltransferase SETDB2", "tax_id": 9913, "disease": "", "pathway": " (bta:509382); (R-BTA-3214841)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.366", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.366", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140947 histone H3K9me2 methyltransferase activity;GO:0003677 DNA binding;GO:0046974 histone H3K9 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005694 chromosome;GO:0005654 nucleoplasm", "go_biological_process": "GO:0032259 methylation;GO:0000278 mitotic cell cycle;GO:0007059 chromosome segregation;GO:0010629 negative regulation of gene expression;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MXG0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MM23-1", "uniprot_id": [ { "id": "F1MM23_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MM23", "type": "external" } ], "mass": 56788.0, "length": 504, "protein_name": "CDK5 regulatory subunit associated protein 3", "gene_name": "CDK5RAP3", "organism": "Bovine", "refseq_name": "CDK5 regulatory subunit-associated protein 3 isoform X1", "refseq_ac": [ { "id": "XP_005220593", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220593", "type": "external" } ], "gene_names_uniprotkb": "CDK5RAP3", "gene_names_refseq": "CDK5RAP3", "protein_names_uniprotkb": "CDK5 regulatory subunit associated protein 3", "protein_names_refseq": "CDK5 regulatory subunit-associated protein 3 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051019 mitogen-activated protein kinase binding;GO:0051059 NF-kappaB binding;GO:0097371 MDM2/MDM4 family protein binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0044389 ubiquitin-like protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0060318 definitive erythrocyte differentiation;GO:0001889 liver development;GO:0008283 cell population proliferation;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MM23-1", "record_type": "protein", 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It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, 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"F1MYG5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MHT1-1", "uniprot_id": [ { "id": "F1MHT1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MHT1", "type": "external" } ], "mass": 174087.0, "length": 1532, "protein_name": "Glycogen debranching enzyme", "gene_name": "AGL", "organism": "Bovine", "refseq_name": "glycogen debranching enzyme", "refseq_ac": [ { "id": "NP_001179400", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179400", "type": "external" } ], "gene_names_uniprotkb": "AGL", "gene_names_refseq": "AGL", "protein_names_uniprotkb": "Glycogen debranching enzyme; 2.4.1.25; 3.2.1.33; Glycogen debrancher", "protein_names_refseq": "amylo-1, 6-glucosidase, 4-alpha-glucanotransferase; glycogen debranching enzyme", "tax_id": 9913, "disease": "", "pathway": " (bta:517397); (R-BTA-6798695); (R-BTA-70221)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0004134 4-alpha-glucanotransferase activity;GO:0004135 amylo-alpha-1,6-glucosidase activity;GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016604 nuclear body;GO:0016234 inclusion body;GO:0005737 cytoplasm", "go_biological_process": "GO:0005978 glycogen biosynthetic process;GO:0005980 glycogen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MHT1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MN65-1", "uniprot_id": [ { "id": "F1MN65_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MN65", "type": "external" } ], "mass": 68846.0, "length": 638, "protein_name": "Sodium-dependent multivitamin transporter", "gene_name": "SLC5A6", "organism": "Bovine", "refseq_name": "sodium-dependent multivitamin transporter isoform X1", "refseq_ac": [ { "id": "XP_024854381", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024854381", "type": "external" } ], "gene_names_uniprotkb": "SLC5A6", "gene_names_refseq": "SLC5A6", "protein_names_uniprotkb": "Sodium-dependent multivitamin transporter; Solute carrier family 5 member 6", "protein_names_refseq": "sodium-dependent multivitamin transporter isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-196780); (R-BTA-199220); (R-BTA-425397)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide. Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake. Required for biotin and pantothenate uptake in the intestine across the brush border membrane. Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin. Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0090482 vitamin transmembrane transporter activity;GO:0015293 symporter activity;GO:0015075 monoatomic ion transmembrane transporter activity;GO:0008523 sodium-dependent multivitamin transmembrane transporter activity;GO:0015111 iodide transmembrane transporter activity", "go_cellular_component": "GO:0016324 apical plasma membrane", "go_biological_process": "GO:0015887 pantothenate transmembrane transport;GO:0006814 sodium ion transport;GO:0015878 biotin transport;GO:0006768 biotin metabolic process;GO:0150104 transport across blood-brain barrier", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MN65-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MMN6-1", "uniprot_id": [ { "id": "F1MMN6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MMN6", "type": "external" } ], "mass": 130995.0, "length": 1179, "protein_name": "Integrin alpha-1", "gene_name": "ITGA1", "organism": "Bovine", "refseq_name": "integrin alpha-1 isoform X1", "refseq_ac": [ { "id": "XP_059734866", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734866", "type": "external" } ], "gene_names_uniprotkb": "ITGA1", "gene_names_refseq": "ITGA1", "protein_names_uniprotkb": "Integrin alpha-1; CD49 antigen-like family member A; Laminin and collagen receptor; VLA-1", "protein_names_refseq": "integrin alpha-1 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:535951); (R-BTA-216083); (R-BTA-445355)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0019903 protein phosphatase binding;GO:0019211 phosphatase activator activity;GO:0038023 signaling receptor activity;GO:0098639 collagen binding involved in cell-matrix adhesion", "go_cellular_component": "GO:0009986 cell surface;GO:0008305 integrin complex;GO:0005925 focal adhesion;GO:0045178 basal part of cell;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0008285 negative regulation of cell population proliferation;GO:0098609 cell-cell adhesion;GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MMN6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MH37-1", "uniprot_id": [ { "id": "F1MH37_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MH37", "type": "external" } ], "mass": 41039.0, "length": 366, "protein_name": "Growth differentiation factor 3", "gene_name": "GDF3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GDF3", "gene_names_refseq": "", "protein_names_uniprotkb": "Growth differentiation factor 3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:786521)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "GO:0048513 animal organ development;GO:0030509 BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MH37-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MWR7-1", "uniprot_id": [ { "id": "F1MWR7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MWR7", "type": "external" } ], "mass": 72248.0, "length": 653, "protein_name": "Kinesin light chain", "gene_name": "KLC4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "KLC4", "gene_names_refseq": "", "protein_names_uniprotkb": "Kinesin light chain", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2132295); (R-BTA-5625970); (R-BTA-983189)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019894 kinesin binding", "go_cellular_component": "GO:0005874 microtubule;GO:0005871 kinesin complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MWR7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MX65-1", "uniprot_id": [ { "id": "F1MX65_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MX65", "type": "external" } ], "mass": 75906.0, "length": 668, "protein_name": "Endoplasmic reticulum lectin", "gene_name": "OS9", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "OS9", "gene_names_refseq": "", "protein_names_uniprotkb": "Endoplasmic reticulum lectin; Protein OS-9", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-382556); (R-BTA-5358346); (R-BTA-9931269)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lectin component of the HRD1 complex, which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). Specifically recognizes and binds improperly folded glycoproteins as well as hyperglycosylated proteins, retain them in the ER, and transfers them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4 as well as hyperglycosylated HSP90B1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0140032 glycosylation-dependent protein binding", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0000836 Hrd1p ubiquitin ligase complex", "go_biological_process": "GO:0030968 endoplasmic reticulum unfolded protein response;GO:0036503 ERAD pathway;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0006621 protein retention in ER lumen", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MX65-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MGQ1-1", "uniprot_id": [ { "id": "F1MGQ1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MGQ1", "type": "external" } ], "mass": 34936.0, "length": 305, "protein_name": "Deoxyribonuclease", "gene_name": "DNASE1L3", "organism": "Bovine", "refseq_name": "deoxyribonuclease gamma precursor", "refseq_ac": [ { "id": "NP_001192653", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192653", "type": "external" } ], "gene_names_uniprotkb": "DNASE1L3", "gene_names_refseq": "DNASE1L3", "protein_names_uniprotkb": "Deoxyribonuclease", "protein_names_refseq": "deoxyribonuclease I-like 3; deoxyribonuclease gamma precursor; deoxyribonuclease gamma", "tax_id": 9913, "disease": "", "pathway": " (bta:512512)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0004519 endonuclease activity;GO:0004536 DNA nuclease activity;GO:0003677 DNA binding;GO:0004530 deoxyribonuclease I activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006308 DNA catabolic process;GO:0002283 neutrophil activation involved in immune response;GO:0070948 regulation of neutrophil mediated cytotoxicity;GO:0006309 apoptotic DNA fragmentation;GO:0010623 programmed cell death involved in cell development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MGQ1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MW29-1", "uniprot_id": [ { "id": "F1MW29_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MW29", "type": "external" } ], "mass": 100392.0, "length": 916, "protein_name": "Cadherin-4", "gene_name": "CDH4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CDH4", "gene_names_refseq": "", "protein_names_uniprotkb": "Cadherin-4; Retinal cadherin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-418990); (R-BTA-525793)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins., [UniProtKB, UniProtKB]; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030057 desmosome;GO:0005912 adherens junction;GO:0016342 catenin complex", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MW29-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MI56-1", "uniprot_id": [ { "id": "F1MI56_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MI56", "type": "external" } ], "mass": 275820.0, "length": 2623, "protein_name": "Ankyrin repeat domain-containing protein 17", "gene_name": "ANKRD17", "organism": "Bovine", "refseq_name": "ankyrin repeat domain-containing protein 17 isoform X1", "refseq_ac": [ { "id": "XP_024848892", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848892", "type": "external" } ], "gene_names_uniprotkb": "ANKRD17", "gene_names_refseq": "ANKRD17", "protein_names_uniprotkb": "Ankyrin repeat domain-containing protein 17; Gene trap ankyrin repeat protein", "protein_names_refseq": "ankyrin repeat domain-containing protein 17 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0045087 innate immune response;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0006275 regulation of DNA replication;GO:0042742 defense response to bacterium;GO:1900087 positive regulation of G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MI56-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MSR0-1", "uniprot_id": [ { "id": "F1MSR0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MSR0", "type": "external" } ], "mass": 40798.0, "length": 355, "protein_name": "Glucose-6-phosphatase", "gene_name": "G6PC2", "organism": "Bovine", "refseq_name": "glucose-6-phosphatase 2", "refseq_ac": [ { "id": "NP_001178975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178975", "type": "external" } ], "gene_names_uniprotkb": "G6PC2", "gene_names_refseq": "G6PC2", "protein_names_uniprotkb": "Glucose-6-phosphatase; 3.1.3.9", "protein_names_refseq": "glucose-6-phosphatase 2", "tax_id": 9913, "disease": "", "pathway": " (bta:505012); (R-BTA-70263)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.25", "type": "external" }, { "id": "3.1.3.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.9", "type": "external" }, { "id": "3.1.3.94", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.94", "type": "external" } ], "go_molecular_function": "GO:0004346 glucose-6-phosphatase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0042593 glucose homeostasis;GO:0050796 regulation of insulin secretion;GO:0051156 glucose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MSR0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MR35-1", "uniprot_id": [ { "id": "F1MR35_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MR35", "type": "external" } ], "mass": 86747.0, "length": 747, "protein_name": "Angiotensin-converting enzyme", "gene_name": "ACE3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ACE3", "gene_names_refseq": "", "protein_names_uniprotkb": "Angiotensin-converting enzyme; 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Olfactory cyclic nucleotide-gated channel subunit 2", "protein_names_refseq": "cyclic nucleotide-gated channel alpha-4", "tax_id": 9913, "disease": "", "pathway": " (bta:516000); (R-BTA-5620916)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity;GO:0005223 intracellularly cGMP-activated cation channel activity;GO:0005222 intracellularly cAMP-activated cation channel activity;GO:0005249 voltage-gated potassium channel activity;GO:0030552 cAMP binding", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0017071 intracellular cyclic nucleotide activated cation channel complex;GO:0098804 non-motile cilium membrane", "go_biological_process": "GO:0098655 monoatomic cation transmembrane transport;GO:0007608 sensory perception of smell;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MM42-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MGS9-1", "uniprot_id": [ { "id": "F1MGS9_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MGS9", "type": "external" } ], "mass": 60258.0, "length": 554, "protein_name": "Macrophage colony-stimulating factor 1", "gene_name": "CSF1", "organism": "Bovine", "refseq_name": "macrophage colony-stimulating factor 1 isoform X2", "refseq_ac": [ { "id": "XP_005204127", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204127", "type": "external" } ], "gene_names_uniprotkb": "CSF1", "gene_names_refseq": "CSF1", "protein_names_uniprotkb": "Macrophage colony-stimulating factor 1; CSF-1; MCSF", "protein_names_refseq": "macrophage colony-stimulating factor 1 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-381426); (R-BTA-449836); (R-BTA-8957275); (R-BTA-9856649)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0042803 protein homodimerization activity;GO:0005157 macrophage colony-stimulating factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:1990682 CSF1-CSF1R complex;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0030225 macrophage differentiation;GO:0002687 positive regulation of leukocyte migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MGS9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MPA7-1", "uniprot_id": [ { "id": "F1MPA7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MPA7", "type": "external" } ], "mass": 36718.0, "length": 327, "protein_name": "G protein pathway suppressor 2", "gene_name": "GPS2", "organism": "Bovine", "refseq_name": "G protein pathway suppressor 2 isoform X1", "refseq_ac": [ { "id": "XP_005220284", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220284", "type": "external" } ], "gene_names_uniprotkb": "GPS2", "gene_names_refseq": "GPS2", "protein_names_uniprotkb": "G protein pathway suppressor 2", "protein_names_refseq": "G protein pathway suppressor 2 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-3214815); (R-BTA-9029569); (R-BTA-9841922)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003714 transcription corepressor activity;GO:0003712 transcription coregulator activity;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0017053 transcription repressor complex;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010875 positive regulation of cholesterol efflux;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0019216 regulation of lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MPA7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MQ06-1", "uniprot_id": [ { "id": "F1MQ06_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MQ06", "type": "external" } ], "mass": 57077.0, "length": 494, "protein_name": "Cholinergic receptor nicotinic alpha 6 subunit", "gene_name": "CHRNA6", "organism": "Bovine", "refseq_name": "neuronal acetylcholine receptor subunit alpha-6 isoform X1", "refseq_ac": [ { "id": "XP_002698774", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698774", "type": "external" } ], "gene_names_uniprotkb": "CHRNA6", "gene_names_refseq": "CHRNA6", "protein_names_uniprotkb": "Cholinergic receptor nicotinic alpha 6 subunit", "protein_names_refseq": "neuronal acetylcholine receptor subunit alpha-6 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:539113); (R-BTA-629594); (R-BTA-629597)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0032991 protein-containing complex;GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0035094 response to nicotine;GO:0095500 acetylcholine receptor signaling pathway;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MQ06-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MQ36-1", "uniprot_id": [ { "id": "F1MQ36_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MQ36", "type": "external" } ], "mass": 80645.0, "length": 718, "protein_name": "Inhibitor of nuclear factor kappa-B kinase subunit epsilon", "gene_name": "IKBKE", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "IKBKE", "gene_names_refseq": "", "protein_names_uniprotkb": "Inhibitor of nuclear factor kappa-B kinase subunit epsilon; 2.7.11.10; Inducible I kappa-B kinase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-4755510); (R-BTA-5357786); (R-BTA-5357905); (R-BTA-936440); (R-BTA-936964); (R-BTA-9824878); (R-BTA-9860927)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0008384 IkappaB kinase activity;GO:0005524 ATP binding;GO:0031625 ubiquitin protein ligase binding;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016605 PML body;GO:0005829 cytosol;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0006974 DNA damage response;GO:0034097 response to cytokine;GO:0060340 positive regulation of type I interferon-mediated signaling pathway;GO:0048255 mRNA stabilization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MQ36-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MSL2-1", "uniprot_id": [ { "id": "F1MSL2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MSL2", "type": "external" } ], "mass": 36747.0, "length": 349, "protein_name": "Thrombopoietin", "gene_name": "THPO", "organism": "Bovine", "refseq_name": "thrombopoietin isoform X2", "refseq_ac": [ { "id": "XP_005201668", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201668", "type": "external" } ], "gene_names_uniprotkb": "THPO", "gene_names_refseq": "THPO", "protein_names_uniprotkb": "Thrombopoietin", "protein_names_refseq": "thrombopoietin isoform X2", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0008283 cell population proliferation;GO:0009891 positive regulation of biosynthetic process;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0035855 megakaryocyte development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MSL2-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MIE6-1", "uniprot_id": [ { "id": "F1MIE6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MIE6", "type": "external" } ], "mass": 274543.0, "length": 2499, "protein_name": "Cation-independent mannose-6-phosphate receptor", "gene_name": "IGF2R", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "IGF2R", "gene_names_refseq": "", "protein_names_uniprotkb": "Cation-independent mannose-6-phosphate receptor; 300 kDa mannose 6-phosphate receptor; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-432722); (R-BTA-6798695); (R-BTA-6811440); (R-BTA-8856825); (R-BTA-8856828)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005537 D-mannose binding;GO:0038023 signaling receptor activity;GO:0042802 identical protein binding;GO:0051219 phosphoprotein binding;GO:0005520 insulin-like growth factor binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0010008 endosome membrane;GO:0005641 nuclear envelope lumen;GO:0005769 early endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0007041 lysosomal transport;GO:0006622 protein targeting to lysosome;GO:0044794 host-mediated activation of viral process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MIE6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MKV7-1", "uniprot_id": [ { "id": "F1MKV7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MKV7", "type": "external" } ], "mass": 396004.0, "length": 3620, "protein_name": "Cubilin", "gene_name": "CUBN", "organism": "Bovine", "refseq_name": "cubilin precursor", "refseq_ac": [ { "id": "NP_001179504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179504", "type": "external" } ], "gene_names_uniprotkb": "CUBN", "gene_names_refseq": "CUBN", "protein_names_uniprotkb": "Cubilin", "protein_names_refseq": "cubilin (intrinsic factor-cobalamin receptor); cubilin precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:523202); (R-BTA-196791); (R-BTA-8964011); (R-BTA-9758881)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0031419 cobalamin binding;GO:0042803 protein homodimerization activity;GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005905 clathrin-coated pit;GO:0005765 lysosomal membrane;GO:0016324 apical plasma membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0015031 protein transport;GO:0009235 cobalamin metabolic process;GO:0015889 cobalamin transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MKV7-1", "record_type": "protein", "filter_code": "0000000.0000001.001000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MRC2-1", "uniprot_id": [ { "id": "F1MRC2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MRC2", "type": "external" } ], "mass": 223333.0, "length": 1940, "protein_name": "Myosin-2", "gene_name": "MYH2", "organism": "Bovine", "refseq_name": "myosin-2", "refseq_ac": [ { "id": "NP_001159699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159699", "type": "external" } ], "gene_names_uniprotkb": "MYH2", "gene_names_refseq": "MYH2; MyHC-2a", "protein_names_uniprotkb": "Myosin-2; Myosin heavy chain 2a; Myosin heavy chain 2; Myosin heavy chain, skeletal muscle, adult 2", "protein_names_refseq": "myosin, heavy chain 2, skeletal muscle, adult; myosin, heavy polypeptide 2, skeletal muscle, adult; myosin-2; type 2a myosin heavy chain", "tax_id": 9913, "disease": "", "pathway": " (bta:788772)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0003774 cytoskeletal motor activity;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016459 myosin complex;GO:0005911 cell-cell junction;GO:0032982 myosin filament;GO:0030016 myofibril", "go_biological_process": "GO:0006936 muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MRC2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MV53-1", "uniprot_id": [ { "id": "F1MV53_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MV53", "type": "external" } ], "mass": 24055.0, "length": 199, "protein_name": "Single-stranded DNA cytosine deaminase", "gene_name": "AICDA", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AICDA", "gene_names_refseq": "", "protein_names_uniprotkb": "Single-stranded DNA cytosine deaminase; 3.5.4.38; Activation-induced cytidine deaminase; Cytidine aminohydrolase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:539888)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.38", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines;GO:0003723 RNA binding;GO:0004126 cytidine deaminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body", "go_biological_process": "GO:0006397 mRNA processing;GO:0016554 cytidine to uridine editing;GO:0051607 defense response to virus;GO:0070383 DNA cytosine deamination;GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MV53-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MJ26-1", "uniprot_id": [ { "id": "F1MJ26_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MJ26", "type": "external" } ], "mass": 78466.0, "length": 716, "protein_name": "Phospholipid phosphatase-related protein type 4", "gene_name": "PLPPR4", "organism": "Bovine", "refseq_name": "phospholipid phosphatase-related protein type 4 isoform X1", "refseq_ac": [ { "id": "XP_003585912", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585912", "type": "external" } ], "gene_names_uniprotkb": "PLPPR4", "gene_names_refseq": "PLPPR4", "protein_names_uniprotkb": "Phospholipid phosphatase-related protein type 4; Brain-specific phosphatidic acid phosphatase-like protein 1; Inactive 2-lysophosphatidate phosphatase PLPPR4; Lipid phosphate phosphatase-related protein type 4; Plasticity-related gene 1 protein", "protein_names_refseq": "phospholipid phosphatase-related protein type 4 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:513388); (R-BTA-419408)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Postsynaptic density membrane protein that indirectly regulates glutamatergic synaptic transmission through lysophosphatidic acid (LPA)-mediated signaling pathways. Binds lysophosphatidic acid (LPA) and mediates its internalization into cells. Could act as receptor or a transporter of this lipid at the post-synaptic membrane. Modulates lysophosphatidic acid (LPA) activity in neuron axonal outgrowth during development by attenuating phospholipid-induced axon collapse., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008195 phosphatidate phosphatase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0098839 postsynaptic density membrane;GO:0098685 Schaffer collateral - CA1 synapse", "go_biological_process": "GO:0006644 phospholipid metabolic process;GO:0007165 signal transduction;GO:0007409 axonogenesis;GO:0051966 regulation of synaptic transmission, glutamatergic;GO:0046839 phospholipid dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MJ26-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MVN0-1", "uniprot_id": [ { "id": "F1MVN0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MVN0", "type": "external" } ], "mass": 124158.0, "length": 1184, "protein_name": "Atrophin 1", "gene_name": "ATN1", "organism": "Bovine", "refseq_name": "atrophin-1", "refseq_ac": [ { "id": "NP_001192677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192677", "type": "external" } ], "gene_names_uniprotkb": "ATN1", "gene_names_refseq": "ATN1", "protein_names_uniprotkb": "Atrophin 1", "protein_names_refseq": "arginine-glutamic acid dipeptide (RE) repeats; atrophin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:513125)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019904 protein domain specific binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016363 nuclear matrix", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0016477 cell migration;GO:0051402 neuron apoptotic process;GO:0030011 maintenance of cell polarity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MVN0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MMQ8-1", "uniprot_id": [ { "id": "F1MMQ8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MMQ8", "type": "external" } ], "mass": 281839.0, "length": 2419, "protein_name": "Spectrin alpha chain, erythrocytic 1", "gene_name": "SPTA1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SPTA1", "gene_names_refseq": "", "protein_names_uniprotkb": "Spectrin alpha chain, erythrocytic 1; Erythroid alpha-spectrin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:505122); (R-BTA-375165); (R-BTA-5673001); (R-BTA-6807878)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005509 calcium ion binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0016020 membrane;GO:0014731 spectrin-associated cytoskeleton;GO:0008091 spectrin;GO:0005886 plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0008360 regulation of cell shape;GO:0051693 actin filament capping", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MMQ8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MY40-1", "uniprot_id": [ { "id": "F1MY40_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MY40", "type": "external" } ], "mass": 120484.0, "length": 1110, "protein_name": "Guanylate cyclase", "gene_name": "GUCY2D", "organism": "Bovine", "refseq_name": "retinal guanylyl cyclase 1 precursor", "refseq_ac": [ { "id": "NP_776973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776973", "type": "external" } ], "gene_names_uniprotkb": "GUCY2D", "gene_names_refseq": "GUCY2D", "protein_names_uniprotkb": "Guanylate cyclase; 4.6.1.2", "protein_names_refseq": "GC-E; RETGC-1; ROS-GC; guanylate cyclase 2D, membrane (retina-specific); guanylate cyclase E; retinal guanylyl cyclase 1 precursor; retinal guanylyl cyclase 1; rod outer segment membrane guanylate cyclase", "tax_id": 9913, "disease": "", "pathway": " (bta:282245); (R-BTA-2514859)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "14993224;15882072;19111294;25767116", "class_list": "", "function": "Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-associated proteins to the photoreceptor outer segment membrane., [UniProtKB, UniProtKB, UniProtKB]; Mg(2+) binding to GCAPs is critical for setting the actual dynamic range of RetGC regulation by GCAPs at physiological levels of free Ca(2+), [RefSeq, PubMed]; The Tyr965-Asn981 region of rod outer segment membrane guanylate cyclase type 1 (ROS-GC1) houses both the structural and functional components that mediate guanylate cyclase activating protein type 2 (GCAP2) regulation., [RefSeq, PubMed]; The coexpression of ROS-GC1 and its activators in spermatozoa suggests that the Ca(2+)-modulated ROS-GC1 transduction system may be a part of the fertilization machinery, [RefSeq, PubMed]; The findings define a new regulatory mechanism of the ROS-GC system that affects visual transduction and is likely to affect the course of retinal diseases caused by cGMP toxicity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0001653 peptide receptor activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0001750 photoreceptor outer segment;GO:0005886 plasma membrane;GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007601 visual perception;GO:0006182 cGMP biosynthetic process;GO:0007168 receptor guanylyl cyclase signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "F1MY40-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MW01-1", "uniprot_id": [ { "id": "F1MW01_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MW01", "type": "external" } ], "mass": 230942.0, "length": 2109, "protein_name": "separase", "gene_name": "ESPL1", "organism": "Bovine", "refseq_name": "separin", "refseq_ac": [ { "id": "NP_001039414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039414", "type": "external" } ], "gene_names_uniprotkb": "ESPL1", "gene_names_refseq": "ESPL1", "protein_names_uniprotkb": "separase; 3.4.22.49", "protein_names_refseq": "extra spindle pole bodies homolog 1; extra spindle poles like 1; extra spindle poles-like protein 1; separin", "tax_id": 9913, "disease": "", "pathway": " (bta:506740); (R-BTA-2467813)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" } ], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0072686 mitotic spindle", "go_biological_process": "GO:0006508 proteolysis;GO:0098813 nuclear chromosome segregation;GO:0000280 nuclear division;GO:0051307 meiotic chromosome separation;GO:0000070 mitotic sister chromatid segregation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MW01-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MH28-1", "uniprot_id": [ { "id": "F1MH28_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MH28", "type": "external" } ], "mass": 84183.0, "length": 780, "protein_name": "TLE family member 1, transcriptional corepressor", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "TLE family member 1, transcriptional corepressor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-201722); (R-BTA-3769402); (R-BTA-4641265); (R-BTA-9764725)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0016055 Wnt signaling pathway;GO:0090090 negative regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MH28-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MGP5-1", "uniprot_id": [ { "id": "F1MGP5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MGP5", "type": "external" } ], "mass": 77162.0, "length": 695, "protein_name": "Methionine synthase reductase", "gene_name": "MTRR", "organism": "Bovine", "refseq_name": "methionine synthase reductase isoform X1", "refseq_ac": [ { "id": "XP_005221697", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221697", "type": "external" } ], "gene_names_uniprotkb": "MTRR", "gene_names_refseq": "MSR; MTRR", "protein_names_uniprotkb": "Methionine synthase reductase; 1.16.1.8; Aquacobalamin reductase", "protein_names_refseq": "methionine synthase reductase isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-156581); (R-BTA-1614635); (R-BTA-9759218)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.13", "type": "external" }, { "id": "1.16.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.8", "type": "external" }, { "id": "1.16.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.6", "type": "external" }, { "id": "2.5.1.151", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.151", "type": "external" } ], "go_molecular_function": "GO:0010181 FMN binding;GO:0030586 [methionine synthase] reductase (NADPH) activity;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0070402 NADPH binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0009235 cobalamin metabolic process;GO:0046655 folic acid metabolic process;GO:0009086 methionine biosynthetic process;GO:0050667 homocysteine metabolic process;GO:0008652 amino acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MGP5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MNV7-1", "uniprot_id": [ { "id": "F1MNV7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MNV7", "type": "external" } ], "mass": 52179.0, "length": 456, "protein_name": "N(6)-adenosine-methyltransferase non-catalytic subunit METTL14", "gene_name": "METTL14", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "METTL14", "gene_names_refseq": "", "protein_names_uniprotkb": "N(6)-adenosine-methyltransferase non-catalytic subunit METTL14; Methyltransferase-like protein 14", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-72203)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0140640 catalytic activity, acting on a nucleic acid;GO:0001734 mRNA m(6)A methyltransferase activity", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0021861 forebrain radial glial cell differentiation;GO:0007283 spermatogenesis;GO:0016556 mRNA modification;GO:0019827 stem cell population maintenance;GO:0061157 mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MNV7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MRT0-1", "uniprot_id": [ { "id": "F1MRT0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MRT0", "type": "external" } ], "mass": 63454.0, "length": 581, "protein_name": "Family with sequence similarity 83 member D", "gene_name": "FAM83D", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FAM83D", "gene_names_refseq": "", "protein_names_uniprotkb": "Family with sequence similarity 83 member D", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-177929)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0019894 kinesin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0097431 mitotic spindle pole", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0007165 signal transduction;GO:0008283 cell population proliferation;GO:0016477 cell migration;GO:0001837 epithelial to mesenchymal transition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MRT0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MGJ1-1", "uniprot_id": [ { "id": "F1MGJ1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MGJ1", "type": "external" } ], "mass": 32848.0, "length": 308, "protein_name": "Peptide-methionine (R)-S-oxide reductase", "gene_name": "MSRB2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MSRB2", "gene_names_refseq": "", "protein_names_uniprotkb": "Peptide-methionine (R)-S-oxide reductase; 1.8.4.12", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5676934)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.12", "type": "external" }, { "id": "1.8.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.14", "type": "external" } ], "go_molecular_function": "GO:0033743 peptide-methionine (R)-S-oxide reductase activity;GO:0033745 L-methionine-(R)-S-oxide reductase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0030091 protein repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MGJ1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MVI8-1", "uniprot_id": [ { "id": "F1MVI8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MVI8", "type": "external" } ], "mass": 51427.0, "length": 445, "protein_name": "DDB1- and CUL4-associated factor 13", "gene_name": "DCAF13", "organism": "Bovine", "refseq_name": "DDB1- and CUL4-associated factor 13 isoform X1", "refseq_ac": [ { "id": "XP_059730470", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059730470", "type": "external" } ], "gene_names_uniprotkb": "DCAF13", "gene_names_refseq": "DCAF13", "protein_names_uniprotkb": "DDB1- and CUL4-associated factor 13; WD repeat and SOF domain-containing protein 1", "protein_names_refseq": "DDB1- and CUL4-associated factor 13 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:100138632); (R-BTA-6791226); (R-BTA-8951664)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Participates in the 18S rRNA processing in growing oocytes, being essential for oocyte nonsurrounded nucleolus (NSN) to surrounded nucleolus (SN) transition., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030331 nuclear estrogen receptor binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0032040 small-subunit processome;GO:0080008 Cul4-RING E3 ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0046697 decidualization;GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0007056 spindle assembly involved in female meiosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MVI8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MU28-1", "uniprot_id": [ { "id": "F1MU28_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MU28", "type": "external" } ], "mass": 88266.0, "length": 781, "protein_name": "B-cell scaffold protein with ankyrin repeats", "gene_name": "BANK1", "organism": "Bovine", "refseq_name": "B-cell scaffold protein with ankyrin repeats isoform X1", "refseq_ac": [ { "id": "XP_010804255", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010804255", "type": "external" } ], "gene_names_uniprotkb": "BANK1", "gene_names_refseq": "BANK1", "protein_names_uniprotkb": "B-cell scaffold protein with ankyrin repeats", "protein_names_refseq": "B-cell scaffold protein with ankyrin repeats isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005102 signaling receptor binding;GO:0035591 signaling adaptor activity;GO:0043274 phospholipase binding;GO:1990782 protein tyrosine kinase binding", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0042113 B cell activation;GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0051246 regulation of protein metabolic process;GO:0050869 negative regulation of B cell activation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MU28-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MYI7-1", "uniprot_id": [ { "id": "F1MYI7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MYI7", "type": "external" } ], "mass": 57725.0, "length": 506, "protein_name": "Cholinergic receptor nicotinic alpha 3 subunit", "gene_name": "CHRNA3", "organism": "Bovine", "refseq_name": "neuronal acetylcholine receptor subunit alpha-3 precursor", "refseq_ac": [ { "id": "NP_001421950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421950", "type": "external" } ], "gene_names_uniprotkb": "CHRNA3", "gene_names_refseq": "CHRNA3", "protein_names_uniprotkb": "Cholinergic receptor nicotinic alpha 3 subunit", "protein_names_refseq": "cholinergic receptor, nicotinic, alpha 3 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 3; neuronal acetylcholine receptor subunit alpha-3 precursor; neuronal acetylcholine receptor subunit alpha-3", "tax_id": 9913, "disease": "", "pathway": " (bta:282702); (R-BTA-629587); (R-BTA-629594); (R-BTA-629597)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "12438106;12438113;21420959", "class_list": "", "function": "Bovine chromaffin cells express nicotinic alpha3beta4 acetylcholine receptors, [RefSeq, PubMed]; Bovine chromaffin cells have an alpha3alpha7beta4 nicotinic receptor, [RefSeq, PubMed]; Data show that a basic residue at position 210 of alpha3 subunit decreases the assembly of heteromeric neuronal alpha3beta4 nicotinic ACh receptors., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0015464 acetylcholine receptor activity", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0032991 protein-containing complex;GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0007399 nervous system development;GO:0035094 response to nicotine;GO:0035095 behavioral response to nicotine", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "F1MYI7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MEV4-1", "uniprot_id": [ { "id": "F1MEV4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MEV4", "type": "external" } ], "mass": 27482.0, "length": 247, "protein_name": "Amphiregulin", "gene_name": "AREG", "organism": "Bovine", "refseq_name": "amphiregulin isoform X2", "refseq_ac": [ { "id": "XP_059743583", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059743583", "type": "external" } ], "gene_names_uniprotkb": "AREG", "gene_names_refseq": "AREGB; AREG", "protein_names_uniprotkb": "Amphiregulin", "protein_names_refseq": "amphiregulin isoform X2", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1257604); (R-BTA-177929); (R-BTA-179812); (R-BTA-180292); (R-BTA-180336); (R-BTA-182971); (R-BTA-204005); (R-BTA-212718); (R-BTA-5673001); (R-BTA-5694530); (R-BTA-6811558); (R-BTA-8856825); (R-BTA-8856828); (R-BTA-9009391)", "pathway_count": 14, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0005154 epidermal growth factor receptor binding;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity", "go_cellular_component": "GO:0016020 membrane;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0009986 cell surface", "go_biological_process": "GO:0007173 epidermal growth factor receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0038134 ERBB2-EGFR signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MEV4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MM35-1", "uniprot_id": [ { "id": "F1MM35_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MM35", "type": "external" } ], "mass": 360757.0, "length": 3173, "protein_name": "Vacuolar protein sorting 13 homolog A", "gene_name": "VPS13A", "organism": "Bovine", "refseq_name": "intermembrane lipid transfer protein VPS13A isoform X1", "refseq_ac": [ { "id": "XP_024851955", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024851955", "type": "external" } ], "gene_names_uniprotkb": "VPS13A", "gene_names_refseq": "VPS13A", "protein_names_uniprotkb": "Vacuolar protein sorting 13 homolog A", "protein_names_refseq": "intermembrane lipid transfer protein VPS13A isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:519494)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005794 Golgi apparatus;GO:0005811 lipid droplet;GO:0043025 neuronal cell body;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006869 lipid transport;GO:1905146 lysosomal protein catabolic process;GO:0045053 protein retention in Golgi apparatus;GO:0006914 autophagy;GO:0006623 protein targeting to vacuole", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MM35-1", "record_type": "protein", "filter_code": "0000000.0000001.001000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MNH3-1", "uniprot_id": [ { "id": "F1MNH3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MNH3", "type": "external" } ], "mass": 388144.0, "length": 3572, "protein_name": "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1", "gene_name": "SVEP1", "organism": "Bovine", "refseq_name": "sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1", "refseq_ac": [ { "id": "XP_010806541", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010806541", "type": "external" } ], "gene_names_uniprotkb": "SVEP1", "gene_names_refseq": "SVEP1", "protein_names_uniprotkb": "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1; Polydom", "protein_names_refseq": "sushi, von 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"F1MNH3-1", "record_type": "protein", "filter_code": "0000000.0000001.001000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MEX9-1", "uniprot_id": [ { "id": "F1MEX9_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MEX9", "type": "external" } ], "mass": 80282.0, "length": 720, "protein_name": "long-chain-fatty-acid--CoA ligase", "gene_name": "ACSL3", "organism": "Bovine", "refseq_name": "fatty acid CoA ligase Acsl3", "refseq_ac": [ { "id": "NP_001192397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192397", "type": "external" } ], "gene_names_uniprotkb": "ACSL3", "gene_names_refseq": "ACSL3", "protein_names_uniprotkb": "long-chain-fatty-acid--CoA ligase; 6.2.1.3", "protein_names_refseq": "fatty acid CoA ligase Acsl3", "tax_id": 9913, "disease": "", "pathway": " (bta:100138312); (R-BTA-434313); (R-BTA-75876)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", 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0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" } ], "go_molecular_function": "GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005811 lipid droplet;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0001676 long-chain fatty acid metabolic process;GO:0034379 very-low-density lipoprotein particle assembly;GO:0042998 positive regulation of Golgi to plasma membrane protein transport;GO:0051047 positive regulation of secretion;GO:2001247 positive regulation of phosphatidylcholine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MEX9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MU00-1", "uniprot_id": [ { "id": "F1MU00_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MU00", "type": "external" } ], "mass": 92861.0, "length": 835, "protein_name": "Sodium/hydrogen exchanger", "gene_name": "SLC9A3", "organism": "Bovine", "refseq_name": "sodium/hydrogen exchanger 3 precursor", "refseq_ac": [ { "id": "NP_001179083", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179083", "type": "external" } ], "gene_names_uniprotkb": "SLC9A3", "gene_names_refseq": "SLC9A3", "protein_names_uniprotkb": "Sodium/hydrogen exchanger", "protein_names_refseq": "sodium proton exchanger; sodium/hydrogen exchanger 3 precursor; solute carrier family 9 (sodium/hydrogen exchanger), member 3", "tax_id": 9913, "disease": "", "pathway": " (bta:407112); (R-BTA-425986)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "21613579", "class_list": "", "function": "Plasma membrane Na(+)/H(+) antiporter. Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis. Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation., [UniProtKB, UniProtKB, UniProtKB]; The expression of NHE3 in the rumen of sheep and cattle and its role in sodium transport are reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0015386 potassium:proton antiporter activity;GO:0042802 identical protein binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0016324 apical plasma membrane;GO:0031901 early endosome membrane;GO:0055038 recycling endosome membrane;GO:0005886 plasma membrane;GO:0070062 extracellular exosome", "go_biological_process": "GO:0006885 regulation of pH;GO:0006883 intracellular sodium ion homeostasis;GO:0051453 regulation of intracellular pH;GO:0071805 potassium ion transmembrane transport;GO:0098719 sodium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MU00-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MGF3-1", "uniprot_id": [ { "id": "F1MGF3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MGF3", "type": "external" } ], "mass": 44594.0, "length": 401, "protein_name": "Endonuclease 8-like 1", "gene_name": "NEIL1", "organism": "Bovine", "refseq_name": "endonuclease 8-like 1 isoform X3", "refseq_ac": [ { "id": "XP_010815357", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010815357", "type": "external" } ], "gene_names_uniprotkb": "NEIL1", "gene_names_refseq": "NEIL1", "protein_names_uniprotkb": "Endonuclease 8-like 1; 4.2.99.18; DNA glycosylase/AP lyase Neil1; DNA-(apurinic or apyrimidinic site) lyase Neil1; Endonuclease VIII-like 1; Nei homolog 1; Nei-like protein 1", "protein_names_refseq": "endonuclease 8-like 1 isoform X3", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-110328); (R-BTA-110329); (R-BTA-5649702)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1MC42", "ec_number_list": [ { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding;GO:0019104 DNA N-glycosylase activity;GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005694 chromosome", "go_biological_process": "GO:0006284 base-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MGF3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MEW8-1", "uniprot_id": [ { "id": "F1MEW8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MEW8", "type": "external" } ], "mass": 59591.0, "length": 540, "protein_name": "Protein Wnt", "gene_name": "WNT10A", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "WNT10A", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein Wnt", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-3238698)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0048733 sebaceous gland development;GO:0030182 neuron differentiation;GO:0071560 cellular response to transforming growth factor beta stimulus;GO:0042476 odontogenesis;GO:0060070 canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MEW8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MEX6-1", "uniprot_id": [ { "id": "F1MEX6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MEX6", "type": "external" } ], "mass": 62300.0, "length": 582, "protein_name": "RBR-type E3 ubiquitin transferase", "gene_name": "RNF19B", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RNF19B", "gene_names_refseq": "", "protein_names_uniprotkb": "RBR-type E3 ubiquitin transferase; 2.3.2.31", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-983168)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0000151 ubiquitin ligase complex;GO:0044194 cytolytic granule", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MEX6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MEZ2-1", "uniprot_id": [ { "id": "F1MEZ2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MEZ2", "type": "external" } ], "mass": 41589.0, "length": 380, "protein_name": "Dual specificity protein phosphatase", "gene_name": "DUSP9", "organism": "Bovine", "refseq_name": "dual specificity protein phosphatase 9", "refseq_ac": [ { "id": "NP_001179956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179956", "type": "external" } ], "gene_names_uniprotkb": "DUSP9", "gene_names_refseq": "DUSP9", "protein_names_uniprotkb": "Dual specificity protein phosphatase; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "dual specificity protein phosphatase 9", "tax_id": 9913, "disease": "", "pathway": " (bta:614306); (R-BTA-112409); (R-BTA-5675221)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", 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0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0008330 protein tyrosine/threonine phosphatase activity;GO:0033550 MAP kinase tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0070373 negative regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MEZ2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MF30-1", "uniprot_id": [ { "id": "F1MF30_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MF30", "type": "external" } ], "mass": 52571.0, "length": 458, "protein_name": "Neuronal acetylcholine receptor subunit beta-3", "gene_name": "CHRNB3", "organism": "Bovine", "refseq_name": "neuronal acetylcholine receptor subunit beta-3", "refseq_ac": [ { "id": "XP_059738359", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059738359", "type": "external" } ], "gene_names_uniprotkb": "CHRNB3", "gene_names_refseq": "CHRNB3", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit beta-3", "protein_names_refseq": "neuronal acetylcholine receptor subunit beta-3", "tax_id": 9913, "disease": "", "pathway": " (bta:521702); (R-BTA-629594); (R-BTA-629597)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. Has an accessory rather than functional role and is only able to form functional nAChRs when co-assembled with another beta subunit. Participates in pentameric assemblies along with CHRNA3, CHRNA4, CHRNA6, CHRNB2 and CHRNB4. Modulates receptor assembly and increases receptor sensitivity to nicotine when associated with CHRNB2, CHRNA4 and/or CHRNA6 as well as CHRNA3 and CHRNB4. Seems to play a role in nicotine addiction., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0035094 response to nicotine;GO:0095500 acetylcholine receptor signaling pathway;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MF30-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MF35-1", "uniprot_id": [ { "id": "F1MF35_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MF35", "type": "external" } ], "mass": 114474.0, "length": 1020, "protein_name": "Metalloendopeptidase", "gene_name": "TLL2", "organism": "Bovine", "refseq_name": "tolloid-like protein 2 isoform X1", "refseq_ac": [ { "id": "XP_002698454", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698454", "type": "external" } ], "gene_names_uniprotkb": "TLL2", "gene_names_refseq": "TLL2", "protein_names_uniprotkb": "Metalloendopeptidase; 3.4.24.-", "protein_names_refseq": "tolloid-like protein 2 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:504975); (R-BTA-1650814); (R-BTA-2243919)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.13", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0016485 protein processing;GO:0030154 cell differentiation;GO:0009953 dorsal/ventral pattern formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MF35-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MF97-1", "uniprot_id": [ { "id": "F1MF97_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MF97", "type": "external" } ], "mass": 142767.0, "length": 1304, "protein_name": "Nidogen-2", "gene_name": "NID2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NID2", "gene_names_refseq": "", "protein_names_uniprotkb": "Nidogen-2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005604 basement membrane", "go_biological_process": "GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MF97-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MFB5-1", "uniprot_id": [ { "id": "F1MFB5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MFB5", "type": "external" } ], "mass": 65587.0, "length": 615, "protein_name": "E3 ubiquitin-protein ligase", "gene_name": "DTX4", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase DTX4 isoform X1", "refseq_ac": [ { "id": "XP_024831705", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831705", "type": "external" } ], "gene_names_uniprotkb": "DTX4", "gene_names_refseq": "DTX4", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase DTX4 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:528508); (R-BTA-2122948); (R-BTA-3270619)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0007219 Notch signaling pathway;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0070936 protein K48-linked ubiquitination;GO:0045824 negative regulation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MFB5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MFI9-1", "uniprot_id": [ { "id": "F1MFI9_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MFI9", "type": "external" } ], "mass": 62031.0, "length": 543, "protein_name": "Cytochrome P450", "gene_name": "CYP2U1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CYP2U1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450; 1.14.14.-", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-211958); (R-BTA-2142816)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. May down-regulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin., [UniProtKB, UniProtKB]; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "1.14.14.80", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.80", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008395 steroid hydroxylase activity;GO:0052869 arachidonate omega-hydroxylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0097267 omega-hydroxylase P450 pathway;GO:0006805 xenobiotic metabolic process;GO:0008202 steroid metabolic process;GO:0006082 organic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MFI9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MFX7-1", "uniprot_id": [ { "id": "F1MFX7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MFX7", "type": "external" } ], "mass": 89948.0, "length": 802, "protein_name": "E3 ubiquitin-protein ligase UHRF", "gene_name": "UHRF2", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase UHRF2", "refseq_ac": [ { "id": "NP_001421860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421860", "type": "external" } ], "gene_names_uniprotkb": "UHRF2", "gene_names_refseq": "UHRF2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase UHRF; 2.3.2.27; RING-type E3 ubiquitin transferase UHRF; Ubiquitin-like PHD and RING finger domain-containing protein; Ubiquitin-like-containing PHD and RING finger domains protein", "protein_names_refseq": "E3 ubiquitin-protein ligase UHRF2; ubiquitin-like, containing PHD and RING finger domains, 2", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-3899300)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0042393 histone binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:0030154 cell differentiation;GO:0016567 protein ubiquitination;GO:0051865 protein autoubiquitination;GO:0051726 regulation of cell cycle;GO:0044027 negative regulation of gene expression via chromosomal CpG island methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MFX7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MFZ3-1", "uniprot_id": [ { "id": "F1MFZ3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MFZ3", "type": "external" } ], "mass": 73558.0, "length": 661, "protein_name": "Potassium voltage-gated channel subfamily A member 4", "gene_name": "KCNA4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "KCNA4", "gene_names_refseq": "", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily A member 4; Voltage-gated potassium channel subunit Kv1.4", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1296072)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0030955 potassium ion binding;GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0016020 membrane;GO:0030424 axon;GO:0043197 dendritic spine;GO:0008076 voltage-gated potassium channel complex;GO:0043194 axon initial segment", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MFZ3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MG23-1", "uniprot_id": [ { "id": "F1MG23_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MG23", "type": "external" } ], "mass": 50615.0, "length": 444, "protein_name": "Orexin receptor type 2", "gene_name": "HCRTR2", "organism": "Bovine", "refseq_name": "orexin receptor type 2", "refseq_ac": [ { "id": "NP_001179606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179606", "type": "external" } ], "gene_names_uniprotkb": "HCRTR2", "gene_names_refseq": "HCRTR2", "protein_names_uniprotkb": "Orexin receptor type 2; Hypocretin receptor type 2", "protein_names_refseq": "orexin receptor type 2", "tax_id": 9913, "disease": "", "pathway": " (bta:529603); (R-BTA-389397); (R-BTA-416476)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "23635422", "class_list": "", "function": "G-protein coupled receptor that binds neuropeptides orexin-A and orexin-B, two neuropeptides derived from a common precursor, prepro-orexin. Upon neuropeptide ligand binding, HCRTR2 can couple with both G(q)/11 and G(i)/o heterotrimeric G-proteins thereby initiating distinct downstream signaling cascades. Involved in regulating the sleep-wake cycle. Contributes to central regulation of glucose homeostasis., [UniProtKB, UniProtKB]; These data confirmed expression of orexin and its two receptors in the bovine adrenal gland., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016499 orexin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0032870 cellular response to hormone stimulus;GO:0042593 glucose homeostasis;GO:0007631 feeding behavior", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MG23-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MG77-1", "uniprot_id": [ { "id": "F1MG77_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MG77", "type": "external" } ], "mass": 86370.0, "length": 781, "protein_name": "Serine/threonine-protein kinase haspin", "gene_name": "HASPIN", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HASPIN", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase haspin; 2.7.11.1; Germ cell-specific gene 2 protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0072354 histone H3T3 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0071459 protein localization to chromosome, centromeric region;GO:0000278 mitotic cell cycle;GO:0035556 intracellular signal transduction;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0007064 mitotic sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MG77-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MG80-1", "uniprot_id": [ { "id": "F1MG80_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MG80", "type": "external" } ], "mass": 35379.0, "length": 309, "protein_name": "N-myc and STAT interactor", "gene_name": "NMI", "organism": "Bovine", "refseq_name": "N-myc-interactor isoform X1", "refseq_ac": [ { "id": "XP_005202486", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202486", "type": "external" } ], "gene_names_uniprotkb": "NMI", "gene_names_refseq": "NMI", "protein_names_uniprotkb": "N-myc and STAT interactor", "protein_names_refseq": "N-myc-interactor isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 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"reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0045087 innate immune response;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0009615 response to virus;GO:0050729 positive regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MG80-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MG82-1", "uniprot_id": [ { "id": "F1MG82_BOVIN", "url": 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"type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.2.1.143", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.143", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" } ], "go_molecular_function": "GO:0004649 poly(ADP-ribose) glycohydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0009225 nucleotide-sugar metabolic process;GO:0006282 regulation of DNA repair;GO:1990966 ATP generation from poly-ADP-D-ribose", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MG95-1", 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"https://www.rhea-db.org/rhea/?query=ec:1.14.15.4", "type": "external" }, { "id": "1.14.15.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.5", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004507 steroid 11-beta-monooxygenase activity;GO:0047783 corticosterone 18-monooxygenase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0006704 glucocorticoid biosynthetic process;GO:0071375 cellular response to peptide hormone stimulus;GO:0032342 aldosterone biosynthetic process;GO:0034650 cortisol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MG97-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MGA6-1", "uniprot_id": [ { "id": "F1MGA6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MGA6", "type": "external" } ], "mass": 56386.0, "length": 515, "protein_name": "Alpha-1B adrenergic receptor", "gene_name": "ADRA1B", "organism": "Bovine", "refseq_name": "alpha-1B adrenergic receptor", "refseq_ac": [ { "id": "NP_001178068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178068", "type": "external" } ], "gene_names_uniprotkb": "ADRA1B", "gene_names_refseq": "ADRA1B", "protein_names_uniprotkb": "Alpha-1B adrenergic receptor; Alpha-1B adrenoreceptor", "protein_names_refseq": "adrenergic, alpha-1B-, receptor; alpha-1B adrenergic receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:407140); (R-BTA-390696); (R-BTA-416476); (R-BTA-416482)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C. ADRA1B binds the catecholamine ligands norepinephrine and epinephrine. Can also couple to G(14) and G(16) proteins. Nuclear ADRA1B forms heterooligomers with ADRA1A to regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. At the plasma membrane, ADRA1B interacts with CAVIN4/MURC to regulates ERK activation in cardiomyocytes, contributing to the regulation of cardiac hypertrophy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0004937 alpha1-adrenergic receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0005901 caveola", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007267 cell-cell signaling;GO:0043410 positive regulation of MAPK cascade;GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0019229 regulation of vasoconstriction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MGA6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MGD1-1", "uniprot_id": [ { "id": "F1MGD1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MGD1", "type": "external" } ], "mass": 47058.0, "length": 424, "protein_name": "E3 ubiquitin-protein ligase RNF135", "gene_name": "RNF135", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RNF135", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF135; 2.3.2.27; RING finger protein 135; RING-type E3 ubiquitin transferase RNF135", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0045087 innate immune response;GO:0000209 protein polyubiquitination;GO:0039529 RIG-I signaling pathway;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MGD1-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MGG3-1", "uniprot_id": [ { "id": "ELL3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MGG3", "type": "external" } ], "mass": 44890.0, "length": 395, "protein_name": "RNA polymerase II elongation factor ELL3", "gene_name": "ELL3", "organism": "Bovine", "refseq_name": "RNA polymerase II elongation factor ELL3", "refseq_ac": [ { "id": "NP_001039591", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039591", "type": "external" } ], "gene_names_uniprotkb": "ELL3", "gene_names_refseq": "ELL3", "protein_names_uniprotkb": "RNA polymerase II elongation factor ELL3", "protein_names_refseq": "RNA polymerase II elongation factor ELL3; 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Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2KI53", "ec_number_list": [], "go_molecular_function": "GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0008023 transcription elongation factor complex", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048863 stem cell differentiation;GO:0006366 transcription by RNA polymerase II;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MGG3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MGH9-1", "uniprot_id": [ { "id": "F1MGH9_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MGH9", "type": "external" } ], "mass": 31203.0, "length": 264, "protein_name": "Alkaline ceramidase", "gene_name": "ACER1", "organism": "Bovine", "refseq_name": "alkaline ceramidase 1", "refseq_ac": [ { "id": "NP_001421888", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421888", "type": "external" } ], "gene_names_uniprotkb": "ACER1", "gene_names_refseq": "ACER1; ASAH3", "protein_names_uniprotkb": "Alkaline ceramidase; 3.5.1.-", "protein_names_refseq": "N-acylsphingosine amidohydrolase (alkaline ceramidase) 3; alkaline ceramidase 1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-9845614)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.60", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0017040 N-acylsphingosine amidohydrolase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0048733 sebaceous gland development;GO:0010446 response to alkaline pH;GO:0046512 sphingosine biosynthetic process;GO:0046514 ceramide catabolic process;GO:0030216 keratinocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MGH9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MGK4-1", "uniprot_id": [ { "id": "F1MGK4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MGK4", "type": "external" } ], "mass": 62584.0, "length": 573, "protein_name": "Eyes absent homolog", "gene_name": "EYA3", "organism": "Bovine", "refseq_name": "protein phosphatase EYA3", "refseq_ac": [ { "id": "NP_001193660", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193660", "type": "external" } ], "gene_names_uniprotkb": "EYA3", "gene_names_refseq": "EYA3", "protein_names_uniprotkb": "Eyes absent homolog; 3.1.3.48", "protein_names_refseq": "eyes absent homolog 3; protein phosphatase EYA3", "tax_id": 9913, "disease": "", "pathway": " (bta:514364); (R-BTA-5693565)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004725 protein tyrosine phosphatase activity;GO:0140793 histone H2AXY142 phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045739 positive regulation of DNA repair;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MGK4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MGK5-1", "uniprot_id": [ { "id": "F1MGK5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MGK5", "type": "external" } ], "mass": 255048.0, "length": 2323, "protein_name": "Receptor-type tyrosine-protein phosphatase zeta", "gene_name": "PTPRZ1", "organism": "Bovine", "refseq_name": "receptor-type tyrosine-protein phosphatase zeta isoform X3", "refseq_ac": [ { "id": "XP_010802704", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802704", "type": "external" } ], "gene_names_uniprotkb": "PTPRZ1", "gene_names_refseq": "PTPRZ1", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase zeta; 3.1.3.48", "protein_names_refseq": "receptor-type tyrosine-protein phosphatase zeta isoform X3", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-449836); (R-BTA-9851151)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0005178 integrin binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0072534 perineuronal net", "go_biological_process": "GO:0007165 signal transduction;GO:0007611 learning or memory;GO:0031175 neuron projection development;GO:0043524 negative regulation of neuron apoptotic process;GO:0031641 regulation of myelination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MGK5-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MGU7-1", "uniprot_id": [ { "id": "F1MGU7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MGU7", "type": "external" } ], "mass": 50232.0, "length": 443, "protein_name": "Fibrinogen gamma chain", "gene_name": "FGG", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FGG", "gene_names_refseq": "", "protein_names_uniprotkb": "Fibrinogen gamma chain", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:280792)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030674 protein-macromolecule adaptor activity;GO:0046872 metal ion binding;GO:0005198 structural molecule activity;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0005577 fibrinogen complex;GO:0031091 platelet alpha granule", "go_biological_process": "GO:0051592 response to calcium ion;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0007160 cell-matrix adhesion;GO:0050714 positive regulation of protein secretion;GO:0042730 fibrinolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MGU7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MGX8-1", "uniprot_id": [ { "id": "F1MGX8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MGX8", "type": "external" } ], "mass": 64333.0, "length": 556, "protein_name": "Protein Spindly", "gene_name": "SPDL1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SPDL1; CCDC99", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein Spindly; Coiled-coil domain-containing protein 99; Spindle apparatus coiled-coil domain-containing protein 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-141430); (R-BTA-141444); (R-BTA-2467813); (R-BTA-2500257); (R-BTA-5663220); (R-BTA-9648025)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for the localization of dynein and dynactin to the mitotic kinetochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Plays a role in cell migration., [UniProtKB, UniProtKB]; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0043515 kinetochore binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005813 centrosome;GO:0000940 outer kinetochore", "go_biological_process": "GO:0016477 cell migration;GO:0051301 cell division;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0007080 mitotic metaphase chromosome alignment;GO:0000132 establishment of mitotic spindle orientation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MGX8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MH30-1", "uniprot_id": [ { "id": "F1MH30_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MH30", "type": "external" } ], "mass": 70898.0, "length": 615, "protein_name": "Phosphodiesterase", "gene_name": "PDE9A", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PDE9A", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphodiesterase; 3.1.4.-", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP. Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart. Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein. In brain, involved in cognitive function, such as learning and long-term memory., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0042383 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"0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MH45-1", "uniprot_id": [ { "id": "F1MH45_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MH45", "type": "external" } ], "mass": 195786.0, "length": 1719, "protein_name": "Serine/threonine-protein kinase MRCK alpha", "gene_name": "CDC42BPA", "organism": "Bovine", "refseq_name": "serine/threonine-protein kinase MRCK alpha", "refseq_ac": [ { "id": "NP_001179866", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179866", "type": "external" } ], "gene_names_uniprotkb": "CDC42BPA", "gene_names_refseq": "CDC42BPA", "protein_names_uniprotkb": "Serine/threonine-protein kinase MRCK alpha; 2.7.11.1; CDC42-binding protein kinase alpha", "protein_names_refseq": "serine/threonine-protein kinase MRCK alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:538392)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", 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"2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030027 lamellipodium", "go_biological_process": "GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MH45-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MHC2-1", "uniprot_id": [ { "id": "F1MHC2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MHC2", "type": "external" } ], "mass": 66666.0, "length": 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neutrophil degranulation;GO:0001909 leukocyte mediated cytotoxicity;GO:0099525 presynaptic dense core vesicle exocytosis;GO:1903305 regulation of regulated secretory pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MHC2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MHC6-1", "uniprot_id": [ { "id": "F1MHC6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MHC6", "type": "external" } ], "mass": 23792.0, "length": 207, "protein_name": "Fibroblast growth factor", "gene_name": "FGF16", "organism": "Bovine", "refseq_name": "fibroblast growth factor 16", "refseq_ac": [ { "id": "NP_001179706", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179706", "type": "external" } ], "gene_names_uniprotkb": "FGF16", "gene_names_refseq": "FGF16; FGF4C", "protein_names_uniprotkb": "Fibroblast growth factor; FGF", "protein_names_refseq": "fibroblast growth 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Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0051781 positive regulation of cell division;GO:0030334 regulation of cell migration;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MHC6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MHH5-1", "uniprot_id": [ { "id": "F1MHH5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MHH5", "type": "external" } ], "mass": 358650.0, "length": 3314, "protein_name": "Cadherin EGF LAG seven-pass G-type receptor 3", "gene_name": "CELSR3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CELSR3", "gene_names_refseq": "", "protein_names_uniprotkb": "Cadherin EGF LAG seven-pass G-type receptor 3; 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(R-BTA-190861)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Structural component of eye lens gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore., [UniProtKB, UniProtKB]; Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage. Involved in intercellular innate immune signaling. Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:1990349 gap junction-mediated intercellular transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MHI7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MHP6-1", "uniprot_id": [ { "id": "F1MHP6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MHP6", "type": "external" } ], "mass": 55465.0, "length": 490, "protein_name": "Adenylosuccinate lyase", "gene_name": "ADSL", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ADSL", "gene_names_refseq": "", "protein_names_uniprotkb": "Adenylosuccinate lyase; 4.3.2.2; ASL; Adenylosuccinase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-73817)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.3.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.2", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity;GO:0070626 (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity", "go_cellular_component": "GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006177 GMP biosynthetic process;GO:0006189 'de novo' IMP biosynthetic process;GO:0044208 'de novo' AMP biosynthetic process;GO:0097294 'de novo' XMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MHP6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MHQ5-1", "uniprot_id": [ { "id": "F1MHQ5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MHQ5", "type": "external" } ], "mass": 55136.0, "length": 477, "protein_name": "mRNA cap guanine-N(7) methyltransferase", "gene_name": "RNMT", "organism": "Bovine", "refseq_name": "mRNA cap guanine-N(7) methyltransferase isoform X1", "refseq_ac": [ { "id": "XP_005224214", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224214", "type": "external" } ], "gene_names_uniprotkb": "RNMT", "gene_names_refseq": "RNMT", "protein_names_uniprotkb": "mRNA cap guanine-N(7) methyltransferase; 2.1.1.56; mRNA (guanine-N(7))-methyltransferase; mRNA cap methyltransferase", "protein_names_refseq": "mRNA cap guanine-N(7) methyltransferase isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-72086); (R-BTA-77075)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.1.1.56", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.56", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0043235 receptor complex;GO:0001650 fibrillar center;GO:0031533 mRNA capping enzyme complex", "go_biological_process": "GO:0006370 7-methylguanosine mRNA capping", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MHQ5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MHS9-1", "uniprot_id": [ { "id": "F1MHS9_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MHS9", "type": "external" } ], "mass": 35453.0, "length": 320, "protein_name": "Olfactory receptor", "gene_name": "OR51E2", "organism": "Bovine", "refseq_name": "olfactory receptor 51E2", "refseq_ac": [ { "id": "NP_001377694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001377694", "type": "external" } ], "gene_names_uniprotkb": "OR51E2", "gene_names_refseq": "OR51E2", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 51E2", "tax_id": 9913, "disease": "", "pathway": " (bta:112441490); (R-BTA-381753)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Putative odorant or sperm cell receptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0003707 nuclear steroid receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:1900135 positive regulation of renin secretion into blood stream;GO:0097325 melanocyte proliferation;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0016477 cell migration;GO:0045777 positive regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MHS9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MHU6-1", "uniprot_id": [ { "id": "F1MHU6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MHU6", "type": "external" } ], "mass": 38203.0, "length": 341, "protein_name": "Renin receptor", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Renin receptor; ATPase H(+)-transporting lysosomal accessory protein 2; ATPase H(+)-transporting lysosomal-interacting protein 2; Renin/prorenin receptor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0009897 external side of plasma membrane;GO:0030665 clathrin-coated vesicle membrane", "go_biological_process": "GO:0030177 positive regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MHU6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MHU9-1", "uniprot_id": [ { "id": "F1MHU9_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MHU9", "type": "external" } ], "mass": 267743.0, "length": 2383, "protein_name": "CCR4-NOT transcription complex subunit 1", "gene_name": "CNOT1", "organism": "Bovine", "refseq_name": "CCR4-NOT transcription complex subunit 1 isoform X7", "refseq_ac": [ { "id": "XP_010812834", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010812834", "type": "external" } ], "gene_names_uniprotkb": "CNOT1", "gene_names_refseq": "CNOT1", "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 1; CCR4-associated factor 1", "protein_names_refseq": "CCR4-NOT transcription complex subunit 1 isoform X7", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-429947); (R-BTA-6804115)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0030331 nuclear estrogen receptor binding;GO:0042974 nuclear retinoic acid receptor binding;GO:0004535 poly(A)-specific ribonuclease activity;GO:0070016 armadillo repeat domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000932 P-body;GO:0030015 CCR4-NOT core complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0001829 trophectodermal cell differentiation;GO:0017148 negative regulation of translation;GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MHU9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MI99-1", "uniprot_id": [ { "id": "F1MI99_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MI99", "type": "external" } ], "mass": 39544.0, "length": 367, "protein_name": "Dual specificity protein phosphatase", "gene_name": "DUSP1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DUSP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Dual specificity protein phosphatase; 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Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. May play a role in clathrin-mediated endocytosis and intracellular trafficking, and in the dynamics of clathrin assembly/disassembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "3.4.17.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.22", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0030276 clathrin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005925 focal adhesion;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0010977 negative regulation of neuron projection development;GO:0048268 clathrin coat assembly;GO:0072583 clathrin-dependent endocytosis;GO:0090160 Golgi to lysosome transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MIB2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MIH1-1", "uniprot_id": [ { "id": "F1MIH1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MIH1", "type": "external" } ], "mass": 29692.0, "length": 284, "protein_name": "Paired like homeobox 2A", "gene_name": "PHOX2A", "organism": "Bovine", "refseq_name": "paired mesoderm homeobox protein 2A", "refseq_ac": [ { "id": "NP_001179086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179086", "type": "external" } ], "gene_names_uniprotkb": "PHOX2A", "gene_names_refseq": "PHOX2A", "protein_names_uniprotkb": "Paired like homeobox 2A", "protein_names_refseq": "paired mesoderm homeobox protein 2A", "tax_id": 9913, "disease": "", "pathway": " (bta:507670)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 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"Solute carrier family 22 member 6", "gene_name": "SLC22A6", "organism": "Bovine", "refseq_name": "solute carrier family 22 member 6", "refseq_ac": [ { "id": "NP_001001143", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001143", "type": "external" } ], "gene_names_uniprotkb": "SLC22A6", "gene_names_refseq": "SLC22A6", "protein_names_uniprotkb": "Solute carrier family 22 member 6", "protein_names_refseq": "ROAT1; organic anion transporter 1; renal organic anion transporter 1; solute carrier family 22 member 6", "tax_id": 9913, "disease": "", "pathway": " (bta:407180); (R-BTA-561048)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015139 alpha-ketoglutarate transmembrane transporter activity;GO:0042910 xenobiotic transmembrane transporter activity;GO:0005452 solute:inorganic anion antiporter activity;GO:0015132 prostaglandin transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0015711 organic anion transport;GO:0097254 renal tubular secretion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MIJ1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MIU2-1", "uniprot_id": [ { "id": "F1MIU2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MIU2", "type": "external" } ], "mass": 62124.0, "length": 585, "protein_name": "BAG family molecular chaperone regulator 3", "gene_name": "BAG3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "BAG3", "gene_names_refseq": "", "protein_names_uniprotkb": "BAG family molecular chaperone regulator 3; Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis", 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"hit_score": 0.1, "record_id": "F1MIU2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MIW8-1", "uniprot_id": [ { "id": "F1MIW8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MIW8", "type": "external" } ], "mass": 112329.0, "length": 1043, "protein_name": "Desmoglein-1", "gene_name": "DSG1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DSG1", "gene_names_refseq": "", "protein_names_uniprotkb": "Desmoglein-1; Desmosomal glycoprotein 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-351906); (R-BTA-6798695); (R-BTA-6805567); (R-BTA-6809371); (R-BTA-9696264); (R-BTA-9696270)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion., [UniProtKB, UniProtKB]; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045295 gamma-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0009898 cytoplasmic side of plasma membrane;GO:0030057 desmosome", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0050821 protein stabilization;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MIW8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MIX5-1", "uniprot_id": [ { "id": "F1MIX5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MIX5", "type": "external" } ], "mass": 46541.0, "length": 407, "protein_name": "Substance-P receptor", "gene_name": "TACR1", "organism": "Bovine", "refseq_name": "substance-P receptor", "refseq_ac": [ { "id": "XP_002691234", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691234", "type": "external" } ], "gene_names_uniprotkb": "TACR1", "gene_names_refseq": "TACR1", "protein_names_uniprotkb": "Substance-P receptor; NK-1 receptor; Tachykinin receptor 1", "protein_names_refseq": "substance-P receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:407133); (R-BTA-380095); (R-BTA-416476); (R-BTA-8856825); (R-BTA-8856828)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016496 substance P receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0097225 sperm midpiece", "go_biological_process": "GO:1902093 positive regulation of flagellated sperm motility", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MIX5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MJ11-1", "uniprot_id": [ { "id": "F1MJ11_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MJ11", "type": "external" } ], "mass": 126142.0, "length": 1138, "protein_name": "Plakophilin 4", "gene_name": "PKP4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PKP4", "gene_names_refseq": "", "protein_names_uniprotkb": "Plakophilin 4", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-6805567); (R-BTA-6809371); (R-BTA-9696264); (R-BTA-9696270); (R-BTA-9696273)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0045296 cadherin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0035023 regulation of Rho protein signal transduction;GO:0007043 cell-cell junction assembly;GO:0032467 positive regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MJ11-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MJ84-1", "uniprot_id": [ { "id": "F1MJ84_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MJ84", "type": "external" } ], "mass": 86007.0, "length": 781, "protein_name": "Vacuolar protein sorting-associated protein 51 homolog", "gene_name": "VPS51", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "VPS51", "gene_names_refseq": "", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 51 homolog", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-6811440)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000938 GARP complex;GO:1990745 EARP complex;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006605 protein targeting;GO:0006914 autophagy;GO:0042147 retrograde transport, endosome to Golgi;GO:0048854 brain morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MJ84-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MK34-1", "uniprot_id": [ { "id": "F1MK34_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MK34", "type": "external" } ], "mass": 55542.0, "length": 487, "protein_name": "Phosphatidylinositol 4-kinase type 2", "gene_name": "PI4K2B", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PI4K2B", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphatidylinositol 4-kinase type 2; 2.7.1.67", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1483248); (R-BTA-1660499); (R-BTA-1660514); (R-BTA-1660516)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004430 1-phosphatidylinositol 4-kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007032 endosome organization;GO:0007030 Golgi organization;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MK34-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MK52-1", "uniprot_id": [ { "id": "F1MK52_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MK52", "type": "external" } ], "mass": 99802.0, "length": 879, "protein_name": "Prominin 1", "gene_name": "PROM1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PROM1", "gene_names_refseq": "", "protein_names_uniprotkb": "Prominin 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, 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"mass": 508289.0, "length": 4424, "protein_name": "Dynein axonemal heavy chain 2", "gene_name": "DNAH2", "organism": "Bovine", "refseq_name": "dynein axonemal heavy chain 2", "refseq_ac": [ { "id": "NP_001178178", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178178", "type": "external" } ], "gene_names_uniprotkb": "DNAH2", "gene_names_refseq": "DNAH2", "protein_names_uniprotkb": "Dynein axonemal heavy chain 2; Axonemal beta dynein heavy chain 2; Ciliary dynein heavy chain 2", "protein_names_refseq": "dynein axonemal heavy chain 2", "tax_id": 9913, "disease": "", "pathway": " (bta:789044)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "39743588", "class_list": "", "function": "As part of the axonemal inner dynein arm complex plays a central role in ciliary beat. Expressed in sperm flagellum, it is required for sperm motility. Dyneins are microtubule-based molecular motors possessing ATPase activities that can convert the chemical energy of ATP into relative sliding between adjacent microtubule doublets to generate ciliary bending., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0097229 sperm end piece;GO:0005874 microtubule;GO:0005930 axoneme;GO:0030286 dynein complex;GO:0036156 inner dynein arm", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0036159 inner dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MK55-1", "record_type": "protein", "filter_code": "0000000.0000101.000100.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MKB5-1", "uniprot_id": [ { "id": "F1MKB5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MKB5", "type": "external" } ], "mass": 39603.0, "length": 360, "protein_name": "Forkhead box protein H1", "gene_name": "FOXH1", "organism": "Bovine", "refseq_name": "forkhead box protein H1", "refseq_ac": [ { "id": "NP_001008414", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008414", "type": "external" } ], "gene_names_uniprotkb": "FOXH1", "gene_names_refseq": "FAST1; FOXH1", "protein_names_uniprotkb": "Forkhead box protein H1; Forkhead activin signal transducer 1; Forkhead activin signal transducer 2", "protein_names_refseq": "forkhead activin signal transducer 1; forkhead box protein H1", "tax_id": 9913, "disease": "", "pathway": " (bta:493733)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070410 co-SMAD binding;GO:0019904 protein domain specific binding;GO:0003714 transcription corepressor activity;GO:0000976 transcription cis-regulatory region binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0000785 chromatin;GO:0032444 activin responsive factor complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0001947 heart looping", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MKB5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MKD1-1", "uniprot_id": [ { "id": "F1MKD1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MKD1", "type": "external" } ], "mass": 25258.0, "length": 223, "protein_name": "N-terminal Xaa-Pro-Lys N-methyltransferase 1", "gene_name": "NTMT1", "organism": "Bovine", "refseq_name": "N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X1", "refseq_ac": [ { "id": "XP_005213456", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213456", "type": "external" } ], "gene_names_uniprotkb": "NTMT1", "gene_names_refseq": "C11H9orf32; C9orf32; METTL11A; NTM1A; NTMT1", "protein_names_uniprotkb": "N-terminal Xaa-Pro-Lys N-methyltransferase 1; 2.1.1.244; Alpha N-terminal protein methyltransferase 1A; Methyltransferase-like protein 11A; X-Pro-Lys N-terminal protein methyltransferase 1A", "protein_names_refseq": "N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by NTMT2-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.244", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.244", "type": "external" } ], "go_molecular_function": "GO:0071885 N-terminal protein N-methyltransferase activity;GO:0042054 histone methyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007059 chromosome segregation;GO:0032259 methylation;GO:0007051 spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MKD1-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MKE9-1", "uniprot_id": [ { "id": "F1MKE9_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MKE9", "type": "external" } ], "mass": 268421.0, "length": 2331, "protein_name": "Spectrin beta chain", "gene_name": "SPTB", "organism": "Bovine", "refseq_name": "spectrin beta chain, erythrocytic", "refseq_ac": [ { "id": "XP_003586637", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586637", "type": "external" } ], "gene_names_uniprotkb": "SPTB", "gene_names_refseq": "SPTB", "protein_names_uniprotkb": "Spectrin beta chain", "protein_names_refseq": "spectrin beta chain, erythrocytic", "tax_id": 9913, "disease": "", "pathway": " (bta:527711); (R-BTA-375165); (R-BTA-5673001); (R-BTA-6807878)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005543 phospholipid binding;GO:0051015 actin filament binding;GO:0030506 ankyrin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0014731 spectrin-associated cytoskeleton", "go_biological_process": "GO:0098885 modification of postsynaptic actin cytoskeleton;GO:0030036 actin cytoskeleton organization;GO:0051693 actin filament capping", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MKE9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MKK7-1", "uniprot_id": [ { "id": "F1MKK7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MKK7", "type": "external" } ], "mass": 54261.0, "length": 497, "protein_name": "Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase", "gene_name": "PKMYT1", "organism": "Bovine", "refseq_name": "membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase", "refseq_ac": [ { "id": "XP_005224691", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005224691", "type": "external" } ], "gene_names_uniprotkb": "PKMYT1", "gene_names_refseq": "PKMYT1", "protein_names_uniprotkb": "Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; 2.7.11.1; Myt1 kinase", "protein_names_refseq": "membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase", "tax_id": 9913, "disease": "", "pathway": " (bta:522613); (R-BTA-156711); (R-BTA-69273); (R-BTA-69478)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0010972 negative regulation of G2/M transition of mitotic cell cycle;GO:0051321 meiotic cell cycle;GO:0110031 negative regulation of G2/MI transition of meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MKK7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MKN2-1", "uniprot_id": [ { "id": "F1MKN2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MKN2", "type": "external" } ], "mass": 31258.0, "length": 285, "protein_name": "DNA-3-methyladenine glycosylase", "gene_name": "MPG", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MPG", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA-3-methyladenine glycosylase; 3-alkyladenine DNA glycosylase; 3-methyladenine DNA glycosidase; 3.2.2.21; ADPG; N-methylpurine-DNA glycosylase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:618306); (R-BTA-110331); (R-BTA-110357)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, 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"0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MKP4-1", "uniprot_id": [ { "id": "F1MKP4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MKP4", "type": "external" } ], "mass": 11897.0, "length": 112, "protein_name": "Urocortin 2", "gene_name": "UCN2", "organism": "Bovine", "refseq_name": "urocortin-2", "refseq_ac": [ { "id": "XP_024839044", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839044", "type": "external" } ], "gene_names_uniprotkb": "UCN2", "gene_names_refseq": "UCN2", "protein_names_uniprotkb": "Urocortin 2", "protein_names_refseq": "urocortin-2", "tax_id": 9913, "disease": "", "pathway": " (bta:751828); (R-BTA-373080)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051429 corticotropin-releasing hormone receptor binding;GO:0042562 hormone binding;GO:0005179 hormone activity;GO:0051431 corticotropin-releasing hormone receptor 2 binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0009755 hormone-mediated signaling pathway;GO:0007586 digestion;GO:0031669 cellular response to nutrient levels", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MKP4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MKU4-1", "uniprot_id": [ { "id": "F1MKU4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MKU4", "type": "external" } ], "mass": 88473.0, "length": 783, "protein_name": "Ubiquitin carboxyl-terminal hydrolase", "gene_name": "USP1", "organism": "Bovine", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 1 isoform X1", "refseq_ac": [ { "id": "XP_059740389", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059740389", "type": "external" } ], "gene_names_uniprotkb": "USP1", "gene_names_refseq": "USP1", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase; 3.4.19.12", "protein_names_refseq": "ubiquitin carboxyl-terminal hydrolase 1 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-110314); (R-BTA-6783310)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB]; Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006281 DNA repair;GO:0006508 proteolysis;GO:0031647 regulation of protein stability;GO:0009411 response to UV;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MKU4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MKW8-1", "uniprot_id": [ { "id": "F1MKW8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MKW8", "type": "external" } ], "mass": 113404.0, "length": 1026, "protein_name": "Serine/threonine-protein kinase SIK3", "gene_name": "SIK2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SIK2", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase SIK3; 2.7.11.1; Salt-inducible kinase 3; Serine/threonine-protein kinase QSK", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 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"secondary_ac_list": "A0A8J8XJQ0;V6F855", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:1904294 positive regulation of ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MKW8-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1ML54-1", "uniprot_id": [ { "id": "F1ML54_BOVIN", "url": "https://www.uniprot.org/uniprot/F1ML54", "type": "external" } ], "mass": 54103.0, "length": 483, "protein_name": "Matrix metallopeptidase 20", "gene_name": "MMP20", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MMP20", "gene_names_refseq": "", "protein_names_uniprotkb": "Matrix metallopeptidase 20", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1442490)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030574 collagen catabolic process;GO:0097186 amelogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1ML54-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1ML62-1", "uniprot_id": [ { "id": "F1ML62_BOVIN", "url": "https://www.uniprot.org/uniprot/F1ML62", "type": "external" } ], "mass": 49276.0, "length": 451, "protein_name": "Photoreceptor-specific nuclear receptor", "gene_name": "NR2E3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NR2E3", "gene_names_refseq": "", "protein_names_uniprotkb": "Photoreceptor-specific nuclear receptor; Nuclear receptor subfamily 2 group E member 3; Retina-specific nuclear receptor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-383280)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F6PQ28", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1ML62-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MLB8-1", "uniprot_id": [ { "id": "F1MLB8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MLB8", "type": "external" } ], "mass": 59690.0, "length": 553, "protein_name": "ATP synthase subunit alpha", "gene_name": "ATP5F1A", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ATP5F1A; LOC512953", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP synthase subunit alpha", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-163210); (R-BTA-8949613); (R-BTA-9837999)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Produces ATP from ADP in the presence of a proton gradient across the membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0043531 ADP binding;GO:0043532 angiostatin binding;GO:0046933 proton-transporting ATP synthase activity, rotational mechanism;GO:0042288 MHC class I protein binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0001937 negative regulation of endothelial cell proliferation;GO:0043536 positive regulation of blood vessel endothelial cell migration;GO:0015986 proton motive force-driven ATP synthesis;GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MLB8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MLI8-1", "uniprot_id": [ { "id": "F1MLI8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MLI8", "type": "external" } ], "mass": 53637.0, "length": 505, "protein_name": "Podocalyxin", "gene_name": "PODXL", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PODXL", "gene_names_refseq": "", "protein_names_uniprotkb": "Podocalyxin; Podocalyxin-like protein 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030027 lamellipodium;GO:0045121 membrane raft;GO:0016324 apical plasma membrane;GO:0030175 filopodium;GO:0001726 ruffle", "go_biological_process": "GO:0007155 cell adhesion;GO:0016477 cell migration;GO:0022408 negative regulation of cell-cell adhesion;GO:0033634 positive regulation of cell-cell adhesion mediated by integrin;GO:0032534 regulation of microvillus assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MLI8-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MLX0-1", "uniprot_id": [ { "id": "FAH2A_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MLX0", "type": "external" } ], "mass": 34541.0, "length": 314, "protein_name": "Oxaloacetate tautomerase FAHD2A, mitochondrial", "gene_name": "FAHD2A", "organism": "Bovine", "refseq_name": "fumarylacetoacetate hydrolase domain-containing protein 2 isoform X1", "refseq_ac": [ { "id": "XP_024854139", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024854139", "type": "external" } ], "gene_names_uniprotkb": "FAHD2A", "gene_names_refseq": "FAHD2A; FAHD2B; FAHD2; OAT1-A; OAT1-B", "protein_names_uniprotkb": "Oxaloacetate tautomerase FAHD2A, mitochondrial; 5.3.2.2; Fumarylacetoacetate hydrolase domain-containing protein 2A; OAT1-A; Oxaloacetate tautomerase 1-A", "protein_names_refseq": "fumarylacetoacetate hydrolase domain-containing protein 2 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "19393038;38287013", "class_list": "", "function": "Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate (PubMed:38287013). It is thereby required to maximize aerobic respiration efficiency by preventing succinate dehydrogenase inhibition (PubMed:38287013)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.3.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.2", "type": "external" }, { "id": "3.7.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.7.1.5", "type": "external" }, { "id": "4.1.1.112", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.112", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0050163 oxaloacetate tautomerase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006107 oxaloacetate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1MLX0-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MM68-1", "uniprot_id": [ { "id": "F1MM68_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MM68", "type": "external" } ], "mass": 53403.0, "length": 469, "protein_name": "interstitial collagenase", "gene_name": "MMP1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MMP1", "gene_names_refseq": "", "protein_names_uniprotkb": "interstitial collagenase; 3.4.24.7", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:281308)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MM68-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MM86-1", "uniprot_id": [ { "id": "F1MM86_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MM86", "type": "external" } ], "mass": 104537.0, "length": 932, "protein_name": "Complement component C6", "gene_name": "C6", "organism": "Bovine", "refseq_name": "complement component C6 isoform X1", "refseq_ac": [ { "id": "XP_010815084", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010815084", "type": "external" } ], "gene_names_uniprotkb": "C6", "gene_names_refseq": "C6", "protein_names_uniprotkb": "Complement component C6", "protein_names_refseq": "complement component C6 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Together with component C5b, involved in MAC complex assembly: complement C5b and C6 associate with the outer leaflet of target cell membrane, reducing the energy for membrane bending., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022829 wide pore channel activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005579 membrane attack complex;GO:0044218 other organism cell membrane", "go_biological_process": "GO:0045766 positive regulation of angiogenesis;GO:0031640 killing of cells of another organism;GO:0006958 complement activation, classical pathway;GO:0001970 positive regulation of activation of membrane attack complex;GO:0160257 complement activation, GZMK pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MM86-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MM88-1", "uniprot_id": [ { "id": "F1MM88_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MM88", "type": "external" } ], "mass": 108246.0, "length": 989, "protein_name": "Serine/threonine-protein kinase Nek9", "gene_name": "NEK9", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NEK9", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase Nek9; 2.7.11.38; Nercc1 kinase; Never in mitosis A-related kinase 9", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2980767); (R-BTA-3301854); (R-BTA-9648025)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MM88-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MMS1-1", "uniprot_id": [ { "id": "F1MMS1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MMS1", "type": "external" } ], "mass": 106733.0, "length": 1045, "protein_name": "TATA-box binding protein associated factor 4", "gene_name": "TAF4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TAF4", "gene_names_refseq": "", "protein_names_uniprotkb": "TATA-box binding protein associated factor 4", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-674695); (R-BTA-6804756); (R-BTA-73776); (R-BTA-73779); (R-BTA-75953); (R-BTA-76042)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0017162 aryl hydrocarbon receptor binding;GO:0001046 core promoter sequence-specific DNA binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0033276 transcription factor TFTC complex;GO:0071339 MLL1 complex;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0042789 mRNA transcription by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MMS1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MMU1-1", "uniprot_id": [ { "id": "F1MMU1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MMU1", "type": "external" } ], "mass": 41783.0, "length": 377, "protein_name": "5-hydroxytryptamine receptor 1D", "gene_name": "HTR1D", "organism": "Bovine", "refseq_name": "5-hydroxytryptamine receptor 1D", "refseq_ac": [ { "id": "XP_015316318", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015316318", "type": "external" } ], "gene_names_uniprotkb": "HTR1D", "gene_names_refseq": "HTR1D", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 1D; Serotonin receptor 1D", "protein_names_refseq": "5-hydroxytryptamine receptor 1D", "tax_id": 9913, "disease": "", "pathway": " (bta:407136); (R-BTA-390666); (R-BTA-418594)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004993 G protein-coupled serotonin receptor activity;GO:0030594 neurotransmitter receptor activity;GO:0051378 serotonin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0006939 smooth muscle contraction;GO:0040012 regulation of locomotion;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MMU1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MMW2-1", "uniprot_id": [ { "id": "F1MMW2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MMW2", "type": "external" } ], "mass": 40940.0, "length": 357, "protein_name": "Deoxyribonuclease-2-beta", "gene_name": "DNASE2B", "organism": "Bovine", "refseq_name": "deoxyribonuclease-2-beta isoform X1", "refseq_ac": [ { "id": "XP_024845141", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024845141", "type": "external" } ], "gene_names_uniprotkb": "DNASE2B", "gene_names_refseq": "DNASE2B", "protein_names_uniprotkb": "Deoxyribonuclease-2-beta; 3.1.22.1; DNase II-like acid DNase; DNase2-like acid DNase; Deoxyribonuclease II beta; Endonuclease DLAD", "protein_names_refseq": "deoxyribonuclease-2-beta isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004531 deoxyribonuclease II activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005764 lysosome", "go_biological_process": "GO:0006309 apoptotic DNA fragmentation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MMW2-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MN84-1", "uniprot_id": [ { "id": "F1MN84_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MN84", "type": "external" } ], "mass": 109402.0, "length": 965, "protein_name": "Aminopeptidase", "gene_name": "ANPEP", "organism": "Bovine", "refseq_name": "aminopeptidase N isoform X1", "refseq_ac": [ { "id": "XP_024837385", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837385", "type": "external" } ], "gene_names_uniprotkb": "ANPEP", "gene_names_refseq": "ANPEP; APN; CD13; P150", "protein_names_uniprotkb": "Aminopeptidase; 3.4.11.-", "protein_names_refseq": "aminopeptidase N isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0001618 virus receptor activity;GO:0016285 alanyl aminopeptidase activity", "go_cellular_component": "GO:0070062 extracellular exosome;GO:0009897 external side of plasma membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0001525 angiogenesis;GO:0030154 cell differentiation;GO:0002003 angiotensin maturation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MN84-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MNH5-1", "uniprot_id": [ { "id": "F1MNH5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MNH5", "type": "external" } ], "mass": 21506.0, "length": 194, "protein_name": "Deubiquitinase DESI2", "gene_name": "DESI2", "organism": "Bovine", "refseq_name": "deubiquitinase DESI2 isoform X2", "refseq_ac": [ { "id": "XP_005216868", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005216868", "type": "external" } ], "gene_names_uniprotkb": "DESI2", "gene_names_refseq": "DESI2; FAM152A; PPPDE1", "protein_names_uniprotkb": "Deubiquitinase DESI2; 3.1.2.22; 3.4.19.12; Desumoylating isopeptidase 2; PPPDE peptidase domain-containing protein 1; Palmitoyl protein thioesterase DESI2; Protein FAM152A; S-depalmitoylase DESI2", "protein_names_refseq": "deubiquitinase DESI2 isoform X2", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization. Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" } ], "go_molecular_function": "GO:0008474 palmitoyl-(protein) hydrolase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity;GO:0052816 long-chain fatty acyl-CoA hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MNH5-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MNQ4-1", "uniprot_id": [ { "id": "F1MNQ4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MNQ4", "type": "external" } ], "mass": 15688.0, "length": 152, "protein_name": "Superoxide dismutase [Cu-Zn]", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Superoxide dismutase [Cu-Zn]; 1.15.1.1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-114608); (R-BTA-3299685)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Destroys radicals which are normally produced within the cells and which are toxic to biological systems., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0005507 copper ion binding;GO:0004784 superoxide dismutase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0019430 removal of superoxide radicals", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MNQ4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MNU7-1", "uniprot_id": [ { "id": "F1MNU7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MNU7", "type": "external" } ], "mass": 160297.0, "length": 1429, "protein_name": "3'-5' RNA helicase YTHDC2", "gene_name": "YTHDC2", "organism": "Bovine", "refseq_name": "3'-5' RNA helicase YTHDC2", "refseq_ac": [ { "id": "NP_001179740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179740", "type": "external" } ], "gene_names_uniprotkb": "YTHDC2", "gene_names_refseq": "YTHDC2", "protein_names_uniprotkb": "3'-5' RNA helicase YTHDC2; 3.6.4.13", "protein_names_refseq": "3'-5' RNA helicase YTHDC2; YTH domain containing 2", "tax_id": 9913, "disease": "", "pathway": " (bta:541024); (R-BTA-9930044)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability. Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs. Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease. Required for both spermatogenesis and oogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0004386 helicase activity;GO:0034458 3'-5' RNA helicase activity", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0048477 oogenesis;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MNU7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MP11-1", "uniprot_id": [ { "id": "F1MP11_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MP11", "type": "external" } ], "mass": 99192.0, "length": 899, "protein_name": "ADAM metallopeptidase with thrombospondin type 1 motif 8", "gene_name": "ADAMTS8", "organism": "Bovine", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 8 precursor", "refseq_ac": [ { "id": "NP_001179254", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179254", "type": "external" } ], "gene_names_uniprotkb": "ADAMTS8", "gene_names_refseq": "ADAMTS8", "protein_names_uniprotkb": "ADAM metallopeptidase with thrombospondin type 1 motif 8", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 8 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:512544); (R-BTA-5173214)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008201 heparin binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MP11-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MP29-1", "uniprot_id": [ { "id": "F1MP29_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MP29", "type": "external" } ], "mass": 134098.0, "length": 1167, "protein_name": "Phospholipid-transporting ATPase", "gene_name": "LOC516849", "organism": "Bovine", "refseq_name": "phospholipid-transporting ATPase FetA isoform X1", "refseq_ac": [ { "id": "XP_010806258", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010806258", "type": "external" } ], "gene_names_uniprotkb": "LOC516849", "gene_names_refseq": "LOC516849", "protein_names_uniprotkb": "Phospholipid-transporting ATPase; 7.6.2.1", "protein_names_refseq": "phospholipid-transporting ATPase FetA isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:516849)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0090555 phosphatidylethanolamine flippase activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001669 acrosomal vesicle;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0045332 phospholipid translocation;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MP29-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MP34-1", "uniprot_id": [ { "id": "F1MP34_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MP34", "type": "external" } ], "mass": 34118.0, "length": 314, "protein_name": "Dual specificity protein phosphatase", "gene_name": "DUSP2", "organism": "Bovine", "refseq_name": "dual specificity protein phosphatase 2", "refseq_ac": [ { "id": "NP_001179108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179108", "type": "external" } ], "gene_names_uniprotkb": "DUSP2", "gene_names_refseq": "DUSP2", "protein_names_uniprotkb": "Dual specificity protein phosphatase; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "dual specificity protein phosphatase 2", "tax_id": 9913, "disease": "", "pathway": " (bta:539140); (R-BTA-112409); (R-BTA-5675221)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Dephosphorylates both phosphorylated Thr and Tyr residues in MAPK1, and dephosphorylation of phosphotyrosine is slightly faster than that of phosphothreonine. Can dephosphorylate MAPK1., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0051019 mitogen-activated protein kinase binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0001706 endoderm formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MP34-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MP61-1", "uniprot_id": [ { "id": "F1MP61_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MP61", "type": "external" } ], "mass": 46493.0, "length": 384, "protein_name": "single-stranded DNA cytosine 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"total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.36", "type": "external" }, { "id": "3.5.4.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.38", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0004126 cytidine deaminase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body", "go_biological_process": "GO:0016554 cytidine to uridine editing;GO:0051607 defense response to virus;GO:0070383 DNA cytosine deamination;GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MP61-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MP88-1", "uniprot_id": [ { "id": "F1MP88_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MP88", "type": "external" } ], "mass": 90208.0, "length": 841, "protein_name": "Dishevelled binding antagonist of beta catenin 1", "gene_name": "DACT1", "organism": "Bovine", "refseq_name": "dapper homolog 1 isoform X1", "refseq_ac": [ { "id": "XP_002691006", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691006", "type": "external" } ], "gene_names_uniprotkb": "DACT1", "gene_names_refseq": "DACT1", "protein_names_uniprotkb": "Dishevelled binding antagonist of beta catenin 1", "protein_names_refseq": "dapper homolog 1 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-4641258)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042826 histone deacetylase binding;GO:0008013 beta-catenin binding;GO:0051018 protein kinase A binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0140416 transcription regulator inhibitor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0030877 beta-catenin destruction complex", "go_biological_process": "GO:1904864 negative regulation of beta-catenin-TCF complex assembly;GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0021915 neural tube development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MP88-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MPI1-1", "uniprot_id": [ { "id": "F1MPI1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MPI1", "type": "external" } ], "mass": 135117.0, "length": 1241, "protein_name": "Renal glomerulus-specific cell adhesion receptor", "gene_name": "NPHS1", "organism": "Bovine", "refseq_name": "nephrin precursor", "refseq_ac": [ { "id": "NP_001179441", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179441", "type": "external" } ], "gene_names_uniprotkb": "NPHS1", "gene_names_refseq": "NPHS1", "protein_names_uniprotkb": "Renal glomerulus-specific cell adhesion receptor", "protein_names_refseq": "NPHS1, nephrin; nephrin precursor; nephrosis 1, congenital, Finnish type (nephrin)", "tax_id": 9913, "disease": "", "pathway": " (bta:519706); (R-BTA-373753)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050839 cell adhesion molecule binding;GO:0017022 myosin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005925 focal adhesion;GO:0042995 cell projection;GO:0036057 slit diaphragm", "go_biological_process": "GO:0036060 slit diaphragm assembly;GO:0098609 cell-cell adhesion;GO:0007520 myoblast fusion;GO:0035418 protein localization to synapse;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MPI1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MPI8-1", "uniprot_id": [ { "id": "F1MPI8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MPI8", "type": "external" } ], "mass": 53283.0, "length": 464, "protein_name": "Cyclin-dependent kinase 8", "gene_name": "CDK8", "organism": "Bovine", "refseq_name": "cyclin-dependent kinase 8 isoform X1", "refseq_ac": [ { "id": "XP_024855845", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855845", "type": "external" } ], "gene_names_uniprotkb": "CDK8", "gene_names_refseq": "CDK8", "protein_names_uniprotkb": "Cyclin-dependent kinase 8; 2.7.11.22; 2.7.11.23; Cell division protein kinase 8", "protein_names_refseq": "cyclin-dependent kinase 8 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:507149); (R-BTA-212436); (R-BTA-2173796); (R-BTA-9841922)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.3.1.199", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.199", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0016592 mediator complex;GO:1990508 CKM complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MPI8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MPJ5-1", "uniprot_id": [ { "id": "F1MPJ5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MPJ5", "type": "external" } ], "mass": 54426.0, "length": 487, "protein_name": "DNA-directed DNA/RNA polymerase mu", "gene_name": "POLM", "organism": "Bovine", "refseq_name": "DNA-directed DNA/RNA polymerase mu isoform X2", "refseq_ac": [ { "id": "XP_024846892", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024846892", "type": "external" } ], "gene_names_uniprotkb": "POLM", "gene_names_refseq": "POLM", "protein_names_uniprotkb": "DNA-directed DNA/RNA polymerase mu; 2.7.7.7", "protein_names_refseq": "DNA-directed DNA/RNA polymerase mu isoform X2", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MPJ5-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MPK1-1", "uniprot_id": [ { "id": "F1MPK1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MPK1", "type": "external" } ], "mass": 48156.0, "length": 422, "protein_name": "Keratin, type I cytoskeletal 20", "gene_name": "KRT20", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "KRT20", "gene_names_refseq": "", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 20; Cytokeratin-20; Keratin-20", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-6805567); (R-BTA-6809371)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0050708 regulation of protein secretion;GO:0009267 cellular response to starvation;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MPK1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MPS1-1", "uniprot_id": [ { "id": "F1MPS1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MPS1", "type": "external" } ], "mass": 25661.0, "length": 224, "protein_name": "Retinoschisin", "gene_name": "RS1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RS1", "gene_names_refseq": "", "protein_names_uniprotkb": "Retinoschisin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides. May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells. Required for normal structure and function of the retina., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane;GO:0001917 photoreceptor inner segment;GO:0032991 protein-containing complex;GO:0098984 neuron to neuron synapse", "go_biological_process": "GO:0007155 cell adhesion;GO:0051260 protein homooligomerization;GO:0007601 visual perception;GO:0010842 retina layer formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MPS1-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MPS7-1", "uniprot_id": [ { "id": "F1MPS7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MPS7", "type": "external" } ], "mass": 40125.0, "length": 387, "protein_name": "Transcription factor Maf", "gene_name": "MAF", "organism": "Bovine", "refseq_name": "transcription factor Maf isoform X1", "refseq_ac": [ { "id": "XP_024834400", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834400", "type": "external" } ], "gene_names_uniprotkb": "MAF", "gene_names_refseq": "C-Maf; MAF", "protein_names_uniprotkb": "Transcription factor Maf", "protein_names_refseq": "transcription factor Maf isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0070306 lens fiber cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MPS7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MPT7-1", "uniprot_id": [ { "id": "F1MPT7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MPT7", "type": "external" } ], "mass": 41399.0, "length": 365, "protein_name": "Ribosome biogenesis regulatory protein", "gene_name": "RRS1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RRS1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ribosome biogenesis regulatory protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in ribosomal large subunit assembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008097 5S rRNA binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:1902570 protein localization to nucleolus;GO:0042273 ribosomal large subunit biogenesis;GO:1901796 regulation of signal transduction by p53 class mediator;GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0007080 mitotic metaphase chromosome alignment", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MPT7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MPW6-1", "uniprot_id": [ { "id": "F1MPW6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MPW6", "type": "external" } ], "mass": 29150.0, "length": 263, "protein_name": "Chromosome 13 C20orf173 homolog", "gene_name": "C13H20orf173", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "C13H20orf173", "gene_names_refseq": "", "protein_names_uniprotkb": "Chromosome 13 C20orf173 homolog", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0097503 sialylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MPW6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MQ33-1", "uniprot_id": [ { "id": "F1MQ33_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MQ33", "type": "external" } ], "mass": 145935.0, "length": 1334, "protein_name": "Sterol regulatory element-binding protein cleavage-activating protein", "gene_name": "SCAP", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SCAP", "gene_names_refseq": "", "protein_names_uniprotkb": "Sterol regulatory element-binding protein cleavage-activating protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1655829)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP-SREBP complex from the endoplasmic reticulum to the Golgi upon low cholesterol, thereby regulating the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. At high sterol concentrations, formation of a ternary complex with INSIG (INSIG1 or INSIG2) leads to mask the ER export signal in SCAP, promoting retention of the complex in the endoplasmic reticulum. Low sterol concentrations trigger release of INSIG, a conformational change in the SSD domain of SCAP, unmasking of the ER export signal, promoting recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi: in the Golgi, SREBPs are then processed, releasing the transcription factor fragment of SREBPs from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. Binds cholesterol via its SSD domain., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032934 sterol binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012507 ER to Golgi transport vesicle membrane;GO:0032936 SREBP-SCAP complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0008203 cholesterol metabolic process;GO:0045540 regulation of cholesterol biosynthetic process;GO:0045542 positive regulation of cholesterol biosynthetic process;GO:0032933 SREBP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MQ33-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MQ47-1", "uniprot_id": [ { "id": "F1MQ47_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MQ47", "type": "external" } ], "mass": 94574.0, "length": 836, "protein_name": "Vacuolar protein sorting-associated protein 16 homolog", "gene_name": "VPS16", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "VPS16", "gene_names_refseq": "", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 16 homolog", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003779 actin binding", "go_cellular_component": "GO:0030897 HOPS complex;GO:0005768 endosome;GO:0005769 early endosome;GO:0055037 recycling endosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0042144 vacuole fusion, non-autophagic;GO:0006886 intracellular protein transport;GO:0008333 endosome to lysosome transport;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MQ47-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MQ92-1", "uniprot_id": [ { "id": "F1MQ92_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MQ92", "type": "external" } ], "mass": 100873.0, "length": 924, "protein_name": "Autophagy-related protein 9", "gene_name": "ATG9B", "organism": "Bovine", "refseq_name": "autophagy-related protein 9B", "refseq_ac": [ { "id": "XP_010802979", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802979", "type": "external" } ], "gene_names_uniprotkb": "ATG9B", "gene_names_refseq": "ATG9B", "protein_names_uniprotkb": "Autophagy-related protein 9", "protein_names_refseq": "autophagy-related protein 9B", "tax_id": 9913, "disease": "", "pathway": " (bta:506862); (R-BTA-1632852)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0005776 autophagosome;GO:0034045 phagophore assembly site membrane;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0034497 protein localization to phagophore assembly site;GO:0000423 mitophagy;GO:0034727 piecemeal microautophagy of the nucleus;GO:0061709 reticulophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MQ92-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MQC0-1", "uniprot_id": [ { "id": "F1MQC0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MQC0", "type": "external" } ], "mass": 16722.0, "length": 146, "protein_name": "Gastric inhibitory polypeptide", "gene_name": "GIP", "organism": "Bovine", "refseq_name": "gastric inhibitory polypeptide precursor", "refseq_ac": [ { "id": "NP_001160077", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160077", "type": "external" } ], "gene_names_uniprotkb": "GIP", "gene_names_refseq": "GIP", "protein_names_uniprotkb": "Gastric inhibitory polypeptide; Glucose-dependent insulinotropic polypeptide", "protein_names_refseq": "gastric inhibitor polypeptide; gastric inhibitory polypeptide precursor; glucose-dependent insulinotropic polypeptide", "tax_id": 9913, "disease": "", "pathway": " (bta:511073); (R-BTA-400511); (R-BTA-418555); (R-BTA-420092)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031769 glucagon receptor binding;GO:0005179 hormone activity;GO:0031767 gastric inhibitory polypeptide receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0042594 response to starvation;GO:0042304 regulation of fatty acid biosynthetic process;GO:0050796 regulation of insulin secretion;GO:0009749 response to glucose", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MQC0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MQC8-1", "uniprot_id": [ { "id": "F1MQC8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MQC8", "type": "external" } ], "mass": 36132.0, "length": 332, "protein_name": "UbiA prenyltransferase domain-containing protein 1", "gene_name": "UBIAD1", "organism": "Bovine", "refseq_name": "ubiA prenyltransferase domain-containing protein 1", "refseq_ac": [ { "id": "XP_002694102", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694102", "type": "external" } ], "gene_names_uniprotkb": "UBIAD1", "gene_names_refseq": "UBIAD1", "protein_names_uniprotkb": "UbiA prenyltransferase domain-containing protein 1; 2.5.1.39", "protein_names_refseq": "ubiA prenyltransferase domain-containing protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:508501); (R-BTA-6806664)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.39", "type": "external" } ], "go_molecular_function": "GO:0016209 antioxidant activity;GO:0004659 prenyltransferase activity;GO:0008412 4-hydroxybenzoate polyprenyltransferase activity;GO:0120566 menadiol geranylgeranyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process;GO:0009234 menaquinone biosynthetic process;GO:0042371 vitamin K biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MQC8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MQD9-1", "uniprot_id": [ { "id": "F1MQD9_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MQD9", "type": "external" } ], "mass": 48178.0, "length": 462, "protein_name": "Protein amnionless", "gene_name": "AMN", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AMN", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein amnionless", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-8964011); (R-BTA-9758881)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0038024 cargo receptor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0043235 receptor complex;GO:0016324 apical plasma membrane;GO:0030139 endocytic vesicle;GO:0031528 microvillus membrane", "go_biological_process": "GO:0097017 renal protein absorption;GO:0006898 receptor-mediated endocytosis;GO:0009235 cobalamin metabolic process;GO:0008104 intracellular protein localization;GO:0015889 cobalamin transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MQD9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MQG2-1", "uniprot_id": [ { "id": "F1MQG2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MQG2", "type": "external" } ], "mass": 36557.0, "length": 336, "protein_name": "Beta-1,3-N-acetylglucosaminyltransferase", "gene_name": "RFNG", "organism": "Bovine", "refseq_name": "beta-1,3-N-acetylglucosaminyltransferase radical fringe isoform X4", "refseq_ac": [ { "id": "XP_024836749", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836749", "type": "external" } ], "gene_names_uniprotkb": "RFNG", "gene_names_refseq": "RFNG", "protein_names_uniprotkb": "Beta-1,3-N-acetylglucosaminyltransferase; 2.4.1.222; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase", "protein_names_refseq": "beta-1,3-N-acetylglucosaminyltransferase radical fringe isoform X4", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.222", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.222", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0007389 pattern specification process;GO:0008593 regulation of Notch signaling pathway", "synthesized_glycan_count": 19, "hit_score": 0.1, "record_id": "F1MQG2-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MQI4-1", "uniprot_id": [ { "id": "F1MQI4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MQI4", "type": "external" } ], "mass": 140058.0, "length": 1213, "protein_name": "Timeless circadian regulator", "gene_name": "TIMELESS", "organism": "Bovine", "refseq_name": "protein timeless homolog", "refseq_ac": [ { "id": "NP_001095541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095541", "type": "external" } ], "gene_names_uniprotkb": "TIMELESS", "gene_names_refseq": "TIMELESS", "protein_names_uniprotkb": "Timeless circadian regulator", "protein_names_refseq": "protein timeless homolog; timeless circadian clock; timeless homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:522884)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008047 enzyme activator activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0031298 replication fork protection complex;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0035861 site of double-strand break", "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0006281 DNA repair;GO:0045892 negative regulation of DNA-templated transcription;GO:0007623 circadian rhythm;GO:0042752 regulation of circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MQI4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MQK6-1", "uniprot_id": [ { "id": "F1MQK6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MQK6", "type": "external" } ], "mass": 212710.0, "length": 1889, "protein_name": "E3 ubiquitin-protein ligase", "gene_name": "UBR3", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase UBR3", "refseq_ac": [ { "id": "XP_059734100", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734100", "type": "external" } ], "gene_names_uniprotkb": "UBR3", "gene_names_refseq": "UBR3", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase UBR3", "tax_id": 9913, "disease": "", "pathway": " (bta:537932)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May play a role in Shh signaling by mediating the ubiquitination of Kif7. May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A., [UniProtKB, UniProtKB]; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0016567 protein ubiquitination;GO:0007608 sensory perception of smell;GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MQK6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MQM7-1", "uniprot_id": [ { "id": "F1MQM7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MQM7", "type": "external" } ], "mass": 49663.0, "length": 457, "protein_name": "Dual specificity protein phosphatase", "gene_name": "DUSP5", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DUSP5", "gene_names_refseq": "", "protein_names_uniprotkb": "Dual specificity protein phosphatase; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-112409); (R-BTA-5675221)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0001706 endoderm formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MQM7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MQX7-1", "uniprot_id": [ { "id": "F1MQX7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MQX7", "type": "external" } ], "mass": 80274.0, "length": 708, "protein_name": "Protein arginine N-methyltransferase", "gene_name": "PRMT7", "organism": "Bovine", "refseq_name": "protein arginine N-methyltransferase 7 isoform X1", "refseq_ac": [ { "id": "XP_024833967", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024833967", "type": "external" } ], "gene_names_uniprotkb": "PRMT7", "gene_names_refseq": "PRMT7", "protein_names_uniprotkb": "Protein arginine N-methyltransferase; 2.1.1.321", "protein_names_refseq": "protein arginine N-methyltransferase 7 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "2.1.1.321", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.321", "type": "external" } ], "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding;GO:0042393 histone binding;GO:0044020 histone H4R3 methyltransferase activity;GO:0035241 protein-arginine omega-N monomethyltransferase activity;GO:0035243 protein-arginine omega-N symmetric methyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0000387 spliceosomal snRNP assembly;GO:0032259 methylation;GO:0071514 genomic imprinting;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MQX7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MQY1-1", "uniprot_id": [ { "id": "F1MQY1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MQY1", "type": "external" } ], "mass": 114178.0, "length": 1025, "protein_name": "DNA ligase", "gene_name": "LIG3", "organism": "Bovine", "refseq_name": "DNA ligase 3 isoform X1", "refseq_ac": [ { "id": "XP_010814069", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010814069", "type": "external" } ], "gene_names_uniprotkb": "LIG3", "gene_names_refseq": "LIG3", "protein_names_uniprotkb": "DNA ligase; 6.5.1.1", "protein_names_refseq": "DNA ligase 3 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-110381); (R-BTA-5649702); (R-BTA-5685939); (R-BTA-6782210)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0003910 DNA ligase (ATP) activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0031981 nuclear lumen;GO:0005634 nucleus", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0097681 double-strand break repair via alternative nonhomologous end joining;GO:0006310 DNA recombination;GO:0051301 cell division;GO:0006284 base-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MQY1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MR40-1", "uniprot_id": [ { "id": "F1MR40_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MR40", "type": "external" } ], "mass": 143712.0, "length": 1333, "protein_name": "Glutamate receptor", "gene_name": "GRIN2D", "organism": "Bovine", "refseq_name": "glutamate receptor ionotropic, NMDA 2D", "refseq_ac": [ { "id": "XP_024834993", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024834993", "type": "external" } ], "gene_names_uniprotkb": "GRIN2D", "gene_names_refseq": "GRIN2D", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "glutamate receptor ionotropic, NMDA 2D", "tax_id": 9913, "disease": "", "pathway": " (bta:618181)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). Participates in synaptic plasticity for learning and memory formation. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators., [UniProtKB, UniProtKB]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0022849 glutamate-gated calcium ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0004972 NMDA glutamate receptor activity", "go_cellular_component": "GO:0017146 NMDA selective glutamate receptor complex;GO:0005886 plasma membrane;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0060079 excitatory postsynaptic potential;GO:0035249 synaptic transmission, glutamatergic;GO:0060291 long-term synaptic potentiation;GO:0097553 calcium ion transmembrane import into cytosol", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MR40-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MRF7-1", "uniprot_id": [ { "id": "F1MRF7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MRF7", "type": "external" } ], "mass": 21934.0, "length": 209, "protein_name": "H/ACA ribonucleoprotein complex subunit", "gene_name": "GAR1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GAR1", "gene_names_refseq": "", "protein_names_uniprotkb": "H/ACA ribonucleoprotein complex subunit", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme., [UniProtKB, UniProtKB]; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine (`psi`) residues may serve to stabilize the conformation of rRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034513 box H/ACA snoRNA binding;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0001650 fibrillar center;GO:0031429 box H/ACA snoRNP complex;GO:0090661 box H/ACA telomerase RNP complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0006364 rRNA processing;GO:0001522 pseudouridine synthesis;GO:0007004 telomere maintenance via telomerase", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MRF7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MRH2-1", "uniprot_id": [ { "id": "F1MRH2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MRH2", "type": "external" } ], "mass": 55315.0, "length": 490, "protein_name": "unspecific monooxygenase", "gene_name": "CYP2C88", "organism": "Bovine", "refseq_name": "cytochrome P450 2C19", "refseq_ac": [ { "id": "XP_002698442", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002698442", "type": "external" } ], "gene_names_uniprotkb": "CYP2C88", "gene_names_refseq": "CYP2C88", "protein_names_uniprotkb": "unspecific monooxygenase; 1.14.14.1", "protein_names_refseq": "cytochrome P450 2C19", "tax_id": 9913, "disease": "", "pathway": " (bta:505468); (R-BTA-211981); (R-BTA-211999); (R-BTA-2142670); (R-BTA-2142816); (R-BTA-9027307); (R-BTA-9749641)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042178 xenobiotic catabolic process;GO:0019373 epoxygenase P450 pathway;GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MRH2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MRI0-1", "uniprot_id": [ { "id": "F1MRI0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MRI0", "type": "external" } ], "mass": 124238.0, "length": 1103, "protein_name": "Guanylate cyclase", "gene_name": "GUCY2F", "organism": "Bovine", "refseq_name": "retinal guanylyl cyclase 2 isoform X1", "refseq_ac": [ { "id": "XP_059739270", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739270", "type": "external" } ], "gene_names_uniprotkb": "GUCY2F", "gene_names_refseq": "GUCY2F", "protein_names_uniprotkb": "Guanylate cyclase; 4.6.1.2", "protein_names_refseq": "retinal guanylyl cyclase 2 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2514859)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0004383 guanylate cyclase activity;GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0001653 peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0120200 rod photoreceptor outer segment", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007601 visual perception;GO:0007168 receptor guanylyl cyclase signaling pathway;GO:0050908 detection of light stimulus involved in visual perception", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MRI0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MRK3-1", "uniprot_id": [ { "id": "AMOL2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MRK3", "type": "external" } ], "mass": 84727.0, "length": 766, "protein_name": "Angiomotin-like protein 2", "gene_name": "AMOTL2", "organism": "Bovine", "refseq_name": "angiomotin-like protein 2 isoform X2", "refseq_ac": [ { "id": "XP_010799902", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010799902", "type": "external" } ], "gene_names_uniprotkb": "AMOTL2", "gene_names_refseq": "AMOTL2", "protein_names_uniprotkb": "Angiomotin-like protein 2", "protein_names_refseq": "angiomotin-like protein 2 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:538514); (R-BTA-2028269)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16305752;19393038", "class_list": "", "function": "Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (By similarity). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (By similarity). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (By similarity). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (By similarity). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (By similarity). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (By similarity). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (By similarity). Selectively promotes FGF-induced MAPK activation through SRC (By similarity). May play a role in the polarity, proliferation and migration of endothelial cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q0V8J3", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0030054 cell junction;GO:0055037 recycling endosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0035329 hippo signaling;GO:0030036 actin cytoskeleton organization;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1MRK3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MRP9-1", "uniprot_id": [ { "id": "F1MRP9_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MRP9", "type": "external" } ], "mass": 102954.0, "length": 957, "protein_name": "Poly [ADP-ribose] polymerase", "gene_name": "PARP10", "organism": "Bovine", "refseq_name": "protein mono-ADP-ribosyltransferase PARP10", "refseq_ac": [ { "id": "XP_002692594", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692594", "type": "external" } ], "gene_names_uniprotkb": "PARP10", "gene_names_refseq": "PARP10", "protein_names_uniprotkb": "Poly [ADP-ribose] polymerase; 2.4.2.-; PARP", "protein_names_refseq": "protein mono-ADP-ribosyltransferase PARP10", "tax_id": 9913, "disease": "", "pathway": " (bta:510991)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0003714 transcription corepressor activity;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0070213 protein auto-ADP-ribosylation;GO:0010629 negative regulation of gene expression;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0048147 negative regulation of fibroblast proliferation;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MRP9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MRS2-1", "uniprot_id": [ { "id": "F1MRS2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MRS2", "type": "external" } ], "mass": 42981.0, "length": 398, "protein_name": "Synaptotagmin-8", "gene_name": "SYT8", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SYT8", "gene_names_refseq": "", "protein_names_uniprotkb": "Synaptotagmin-8; Synaptotagmin VIII", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-8856825); (R-BTA-8856828)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of exocytosis in insulin secreted cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0005544 calcium-dependent phospholipid binding;GO:0000149 SNARE binding;GO:0061891 calcium ion sensor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0001669 acrosomal vesicle;GO:0030672 synaptic vesicle membrane;GO:0070382 exocytic vesicle", "go_biological_process": "GO:0007340 acrosome reaction;GO:0016192 vesicle-mediated transport;GO:0017158 regulation of calcium ion-dependent exocytosis;GO:2000300 regulation of synaptic vesicle exocytosis;GO:0099502 calcium-dependent activation of synaptic vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MRS2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MRW5-1", "uniprot_id": [ { "id": "F1MRW5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MRW5", "type": "external" } ], "mass": 54857.0, "length": 499, "protein_name": "Cell division cycle protein 20 homolog", "gene_name": "CDC20", "organism": "Bovine", "refseq_name": "cell division cycle protein 20 homolog isoform X1", "refseq_ac": [ { "id": "XP_005204788", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005204788", "type": "external" } ], "gene_names_uniprotkb": "CDC20", "gene_names_refseq": "CDC20", "protein_names_uniprotkb": "Cell division cycle protein 20 homolog; p55CDC", "protein_names_refseq": "cell division cycle protein 20 homolog isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-141405); (R-BTA-141430); (R-BTA-141444); (R-BTA-174048); (R-BTA-174113); (R-BTA-174154); (R-BTA-174178); (R-BTA-174184); (R-BTA-176407); (R-BTA-176408); (R-BTA-176409); (R-BTA-176417); (R-BTA-179409); (R-BTA-2467813); (R-BTA-2500257); (R-BTA-5663220); (R-BTA-5689880); (R-BTA-9648025); (R-BTA-983168)", "pathway_count": 19, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation. Recognizes and binds the destruction box (D box) on protein substrates. Involved in the metaphase/anaphase transition of cell cycle. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0010997 anaphase-promoting complex binding;GO:1990757 ubiquitin ligase activator activity", "go_cellular_component": "GO:0005813 centrosome;GO:0000776 kinetochore;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0031915 positive regulation of synaptic plasticity;GO:0090129 positive regulation of synapse maturation;GO:0045842 positive regulation of mitotic metaphase/anaphase transition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MRW5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MRW7-1", "uniprot_id": [ { "id": "F1MRW7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MRW7", "type": "external" } ], "mass": 92666.0, "length": 825, "protein_name": "Probable ATP-dependent RNA helicase DDX20", "gene_name": "DDX20", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DDX20", "gene_names_refseq": "", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX20; 3.6.1.15; 3.6.4.13; Component of gems 3; DEAD box protein 20; DEAD box protein DP 103; Gemin-3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-191859)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0032797 SMN complex;GO:0090571 RNA polymerase II transcription repressor complex;GO:0097504 Gemini of Cajal bodies", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0043065 positive regulation of apoptotic process;GO:0000387 spliceosomal snRNP assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MRW7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MRZ8-1", "uniprot_id": [ { "id": "F1MRZ8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MRZ8", "type": "external" } ], "mass": 40057.0, "length": 350, "protein_name": "Pleckstrin", "gene_name": "PLEK", "organism": "Bovine", "refseq_name": "pleckstrin", "refseq_ac": [ { "id": "NP_001179425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179425", "type": "external" } ], "gene_names_uniprotkb": "PLEK", "gene_names_refseq": "PLEK", "protein_names_uniprotkb": "Pleckstrin", "protein_names_refseq": "pleckstrin", "tax_id": 9913, "disease": "", "pathway": " (bta:518658); (R-BTA-114608)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "30573663", "class_list": "", "function": "Major protein kinase C substrate of platelets., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0005080 protein kinase C binding;GO:0019211 phosphatase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0032587 ruffle membrane", "go_biological_process": "GO:0032233 positive regulation of actin filament bundle assembly;GO:0007229 integrin-mediated signaling pathway;GO:0035556 intracellular signal transduction;GO:0030036 actin cytoskeleton organization;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MRZ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MS32-1", "uniprot_id": [ { "id": "F1MS32_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MS32", "type": "external" } ], "mass": 21401.0, "length": 189, "protein_name": "Apolipoprotein D", "gene_name": "APOD", "organism": "Bovine", "refseq_name": "apolipoprotein D precursor", "refseq_ac": [ { "id": "NP_001069769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069769", "type": "external" } ], "gene_names_uniprotkb": "APOD", "gene_names_refseq": "APOD", "protein_names_uniprotkb": "Apolipoprotein D; Apo-D", "protein_names_refseq": "apo-D; apolipoprotein D precursor", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-804914)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015485 cholesterol binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006869 lipid transport;GO:0007420 brain development;GO:0000302 response to reactive oxygen species;GO:0042246 tissue regeneration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MS32-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MSF1-1", "uniprot_id": [ { "id": "F1MSF1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MSF1", "type": "external" } ], "mass": 89991.0, "length": 791, "protein_name": "Ribonucleoside-diphosphate reductase", "gene_name": "RRM1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RRM1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ribonucleoside-diphosphate reductase; 1.17.4.1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-499943)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, 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During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG. Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes., [UniProtKB, UniProtKB]; These results suggest that the SNP of the GDF5 gene could be a very useful genetic marker for body measurement traits in the bovine reproduction and breeding., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0036122 BMP binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0050680 negative regulation of epithelial cell proliferation;GO:0030509 BMP signaling pathway;GO:0030513 positive regulation of BMP signaling pathway;GO:0032332 positive regulation of chondrocyte differentiation;GO:0032331 negative regulation of chondrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MT44-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MT46-1", "uniprot_id": [ { "id": "F1MT46_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MT46", "type": "external" } ], "mass": 68230.0, "length": 642, "protein_name": "Solute carrier family 5 member 5", "gene_name": "SLC5A5", "organism": "Bovine", "refseq_name": "sodium/iodide cotransporter", "refseq_ac": [ { "id": "XP_024850554", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850554", "type": "external" } ], "gene_names_uniprotkb": "SLC5A5", "gene_names_refseq": "SLC5A5", "protein_names_uniprotkb": "Solute carrier family 5 member 5", "protein_names_refseq": "sodium/iodide cotransporter", "tax_id": 9913, "disease": "", "pathway": " (bta:505310); (R-BTA-209968); (R-BTA-9958790)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0008507 sodium:iodide symporter activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0071320 cellular response to cAMP;GO:1904322 cellular response to forskolin;GO:0006814 sodium ion transport;GO:0006590 thyroid hormone generation;GO:1904401 cellular response to Thyroid stimulating hormone", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MT46-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MT63-1", "uniprot_id": [ { "id": "F1MT63_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MT63", "type": "external" } ], "mass": 35813.0, "length": 341, "protein_name": "Homeobox protein Hox-D13", "gene_name": "HOXD13", "organism": "Bovine", "refseq_name": "homeobox protein Hox-D13", "refseq_ac": [ { "id": "XP_024835852", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835852", "type": "external" } ], "gene_names_uniprotkb": "HOXD13", "gene_names_refseq": "HOXD13", "protein_names_uniprotkb": "Homeobox protein Hox-D13", "protein_names_refseq": "homeobox protein Hox-D13", "tax_id": 9913, "disease": "", "pathway": " (bta:100336775)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MT63-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MT65-1", "uniprot_id": [ { "id": "F1MT65_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MT65", "type": "external" } ], "mass": 74681.0, "length": 673, "protein_name": "Hepatoma-derived growth factor-related protein 2", "gene_name": "HDGFL2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HDGFL2", "gene_names_refseq": "", "protein_names_uniprotkb": "Hepatoma-derived growth factor-related protein 2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0061628 histone H3K27me3 reader activity;GO:0062072 histone H3K9me2/3 reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling;GO:0030307 positive regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MT65-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MT97-1", "uniprot_id": [ { "id": "F1MT97_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MT97", "type": "external" } ], "mass": 53327.0, "length": 468, "protein_name": "interstitial collagenase", "gene_name": "LOC112441463", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LOC112441463", "gene_names_refseq": "", "protein_names_uniprotkb": "interstitial collagenase; 3.4.24.7", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1442490); (R-BTA-1474228); (R-BTA-1592389)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.7", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.4.21.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.34", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MT97-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MTA8-1", "uniprot_id": [ { "id": "F1MTA8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MTA8", "type": "external" } ], "mass": 71817.0, "length": 643, "protein_name": "Dynein axonemal assembly factor 1", "gene_name": "DNAAF1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DNAAF1", "gene_names_refseq": "", "protein_names_uniprotkb": "Dynein axonemal assembly factor 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070840 dynein complex binding", "go_cellular_component": "GO:0005930 axoneme", "go_biological_process": "GO:0030324 lung development;GO:0007368 determination of left/right symmetry;GO:0001947 heart looping;GO:0044458 motile cilium assembly;GO:0003341 cilium movement", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MTA8-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MTD6-1", "uniprot_id": [ { "id": "F1MTD6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MTD6", "type": "external" } ], "mass": 59038.0, "length": 524, "protein_name": "Protein phosphatase 1 regulatory subunit 19", "gene_name": "URI1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "URI1", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 19; RNA polymerase II subunit 5-mediating protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity;GO:0051219 phosphoprotein binding;GO:0019212 phosphatase inhibitor activity;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0009615 response to virus;GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0071363 cellular response to growth factor stimulus;GO:0001558 regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MTD6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MTV1-1", "uniprot_id": [ { "id": "F1MTV1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MTV1", "type": "external" } ], "mass": 62281.0, "length": 553, "protein_name": "Hyaluronidase", "gene_name": "SPAM1", "organism": "Bovine", "refseq_name": "sperm adhesion molecule 1 precursor", "refseq_ac": [ { "id": "NP_001008413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008413", "type": "external" } ], "gene_names_uniprotkb": "SPAM1", "gene_names_refseq": "PH-20; SPAM1", "protein_names_uniprotkb": "Hyaluronidase; 3.2.1.35", "protein_names_refseq": "hyaluronidase, zona pellucida binding; sperm adhesion molecule 1 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:353352)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18337076;18492482;19812301;21320470;25761683;30328344", "class_list": "", "function": "Bovine testicular hyaluronidase 3D-model demonstrated lysine residue stratification during enzyme modification., [RefSeq, PubMed]; PH-20 transcripts are found in bovine testis and the protein is present in ejaculated spermatozoa., [RefSeq, PubMed]; Results clearly demonstrate that ejaculated bull sperm possess two forms of sperm adhesion molecule 1(SPAM1): one (epididymal) expressed at the surface, and one (testicular) that interacts with the zona pellucida after the acrosome exocytosis., [RefSeq, PubMed]; The effect of metal cations on the transglycosylation by bovine testicular hyaluronidase using as substrates metal salts of glycosaminoglycan chains was investigated., [RefSeq, PubMed]; The hydrolysis Vm values strongly suggest that as the chain length decreases the hyaluronidase increasingly catalyses transglycosylation rather than hydrolysis., [RefSeq, PubMed]; The simplicity, sensitivity, and versatility of the fluorescent substrate (termed FRET-HA) suggest that it will have utility in a variety of assay platforms and should be a new tool for assessing hyaluronidase activity., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004415 hyalurononglucosaminidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001669 acrosomal vesicle;GO:0098552 side of membrane", "go_biological_process": "GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0005975 carbohydrate metabolic process;GO:0030214 hyaluronan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "F1MTV1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MU47-1", "uniprot_id": [ { "id": "F1MU47_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MU47", "type": "external" } ], "mass": 52567.0, "length": 457, "protein_name": "steroid 11beta-monooxygenase", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "steroid 11beta-monooxygenase; 1.14.15.4", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-194002); (R-BTA-211976)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.15.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.4", "type": "external" }, { "id": "1.14.15.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.5", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004507 steroid 11-beta-monooxygenase activity;GO:0047783 corticosterone 18-monooxygenase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0006704 glucocorticoid biosynthetic process;GO:0071375 cellular response to peptide hormone stimulus;GO:0032342 aldosterone biosynthetic process;GO:0034650 cortisol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MU47-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MU56-1", "uniprot_id": [ { "id": "F1MU56_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MU56", "type": "external" } ], "mass": 32319.0, "length": 289, "protein_name": "Matrix metallopeptidase 7", "gene_name": "MMP7", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MMP7", "gene_names_refseq": "", "protein_names_uniprotkb": "Matrix metallopeptidase 7", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1442490); (R-BTA-1474228); (R-BTA-1592389); (R-BTA-9009391)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030335 positive regulation of cell migration;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MU56-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MU79-1", "uniprot_id": [ { "id": "F1MU79_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MU79", "type": "external" } ], "mass": 51559.0, "length": 459, "protein_name": "peptidylprolyl isomerase", "gene_name": "FKBP4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FKBP4", "gene_names_refseq": "", "protein_names_uniprotkb": "peptidylprolyl isomerase; 5.2.1.8", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-3371497); (R-BTA-3371568); (R-BTA-8939211); (R-BTA-9018519)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" } ], "go_molecular_function": "GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005874 microtubule", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MU79-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MUD4-1", "uniprot_id": [ { "id": "F1MUD4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MUD4", "type": "external" } ], "mass": 150290.0, "length": 1363, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 19", "gene_name": "USP19", "organism": "Bovine", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 19 isoform X1", "refseq_ac": [ { "id": "XP_005223068", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223068", "type": "external" } ], "gene_names_uniprotkb": "USP19", "gene_names_refseq": "USP19", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 19; 3.4.19.12; Deubiquitinating enzyme 19; Ubiquitin thioesterase 19; Ubiquitin-specific-processing protease 19", "protein_names_refseq": "ubiquitin carboxyl-terminal hydrolase 19 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:514587); (R-BTA-5689880)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0051879 Hsp90 protein binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:1904292 regulation of ERAD pathway;GO:0016579 protein deubiquitination;GO:0050821 protein stabilization;GO:0031647 regulation of protein stability;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MUD4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MUG2-1", "uniprot_id": [ { "id": "CEP41_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MUG2", "type": "external" } ], "mass": 41380.0, "length": 373, "protein_name": "Centrosomal protein of 41 kDa", "gene_name": "CEP41", "organism": "Bovine", "refseq_name": "centrosomal protein of 41 kDa", "refseq_ac": [ { "id": "NP_001179050", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179050", "type": "external" } ], "gene_names_uniprotkb": "CEP41", "gene_names_refseq": "CEP41; TSGA14", "protein_names_uniprotkb": "Centrosomal protein of 41 kDa; Cep41", "protein_names_refseq": "centrosomal protein 41kDa; centrosomal protein of 41 kDa; testis specific, 14", "tax_id": 9913, "disease": "", "pathway": " (bta:506914); (R-BTA-2565942); (R-BTA-380259); (R-BTA-380270); (R-BTA-380284); (R-BTA-380320); (R-BTA-5620912); (R-BTA-8854518)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0015031 protein transport;GO:0060271 cilium assembly;GO:0018095 protein polyglutamylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MUG2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MUS9-1", "uniprot_id": [ { "id": "PSD1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MUS9", "type": "external" } ], "mass": 109765.0, "length": 1026, "protein_name": "PH and SEC7 domain-containing protein 1", "gene_name": "PSD", "organism": "Bovine", "refseq_name": "PH and SEC7 domain-containing protein 1", "refseq_ac": [ { "id": "NP_001178404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178404", "type": "external" } ], "gene_names_uniprotkb": "PSD", "gene_names_refseq": "PSD", "protein_names_uniprotkb": "PH and SEC7 domain-containing protein 1; Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6; Exchange factor for ARF6 A; Exchange factor for ARF6; Pleckstrin homology and SEC7 domain-containing protein 1", "protein_names_refseq": "PH and SEC7 domain-containing protein 1; exchange factor for ADP-ribosylation factor guanine nucleotide factor 6; exchange factor for ARF6 A; pleckstrin homology and SEC7 domain-containing protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:523124)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Guanine nucleotide exchange factor for ARF6 (By similarity). Induces cytoskeletal remodeling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6QNS4", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0032154 cleavage furrow;GO:0032587 ruffle membrane", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0032012 regulation of ARF protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MUS9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MUZ2-1", "uniprot_id": [ { "id": "F1MUZ2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MUZ2", "type": "external" } ], "mass": 39205.0, "length": 350, "protein_name": "Protein O-mannose kinase", "gene_name": "POMK", "organism": "Bovine", "refseq_name": "protein O-mannose kinase isoform X1", "refseq_ac": [ { "id": "XP_005226163", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226163", "type": "external" } ], "gene_names_uniprotkb": "POMK", "gene_names_refseq": "POMK; SGK196", "protein_names_uniprotkb": "Protein O-mannose kinase; 2.7.1.183; Protein kinase-like protein SgK196; Sugen kinase 196", "protein_names_refseq": "protein O-mannose kinase isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-8932505)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "glycan-modifying enzyme;glycogene", "function": "Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.183", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.183", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0019200 carbohydrate kinase activity;GO:0016773 phosphotransferase activity, alcohol group as acceptor", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006493 protein O-linked glycosylation", "synthesized_glycan_count": 17, "hit_score": 0.1, "record_id": "F1MUZ2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.10010", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MUZ8-1", "uniprot_id": [ { "id": "F1MUZ8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MUZ8", "type": "external" } ], "mass": 35701.0, "length": 313, "protein_name": "Aspartoacylase", "gene_name": "ASPA", "organism": "Bovine", "refseq_name": "aspartoacylase isoform X1", "refseq_ac": [ { "id": "XP_005220265", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220265", "type": "external" } ], "gene_names_uniprotkb": "ASPA", "gene_names_refseq": "ASPA; ASP", "protein_names_uniprotkb": "Aspartoacylase; 3.5.1.15; Aminoacylase-2", "protein_names_refseq": "aspartoacylase isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-8963693)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it acts as a scavenger of NAA from body fluids., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.15", "type": "external" } ], "go_molecular_function": "GO:0016788 hydrolase activity, acting on ester bonds;GO:0019807 aspartoacylase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006083 acetate metabolic process;GO:0006531 aspartate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MUZ8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MV40-1", "uniprot_id": [ { "id": "F1MV40_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MV40", "type": "external" } ], "mass": 43379.0, "length": 426, "protein_name": "Voltage-dependent calcium channel gamma-8 subunit", "gene_name": "CACNG8", "organism": "Bovine", "refseq_name": "calcium voltage-gated channel auxiliary subunit gamma 8", "refseq_ac": [ { "id": "NP_001422844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422844", "type": "external" } ], "gene_names_uniprotkb": "CACNG8", "gene_names_refseq": "CACNG8", "protein_names_uniprotkb": "Voltage-dependent calcium channel gamma-8 subunit", "protein_names_refseq": "calcium voltage-gated channel auxiliary subunit gamma 8", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-399719); (R-BTA-5576892); (R-BTA-5576893); (R-BTA-5682910)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005245 voltage-gated calcium channel activity;GO:0016247 channel regulator activity", "go_cellular_component": "GO:0032281 AMPA glutamate receptor complex;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0051968 positive regulation of synaptic transmission, glutamatergic;GO:0019226 transmission of nerve impulse;GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MV40-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MV95-1", "uniprot_id": [ { "id": "F1MV95_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MV95", "type": "external" } ], "mass": 91423.0, "length": 796, "protein_name": "Toll-like receptor", "gene_name": "TLR6", "organism": "Bovine", "refseq_name": "toll-like receptor 6 isoform X1", "refseq_ac": [ { "id": "XP_010804360", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010804360", "type": "external" } ], "gene_names_uniprotkb": "TLR6", "gene_names_refseq": "TLR1; TLR6", "protein_names_uniprotkb": "Toll-like receptor", "protein_names_refseq": "toll-like receptor 6 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5686938)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0071723 lipopeptide binding;GO:0042498 diacyl lipopeptide binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0035355 Toll-like receptor 2-Toll-like receptor 6 protein complex", "go_biological_process": "GO:0043032 positive regulation of macrophage activation;GO:0034136 negative regulation of toll-like receptor 2 signaling pathway;GO:0006954 inflammatory response;GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:1904646 cellular response to amyloid-beta", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MV95-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MV99-1", "uniprot_id": [ { "id": "SSR5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MV99", "type": "external" } ], "mass": 39961.0, "length": 368, "protein_name": "Somatostatin receptor type 5", "gene_name": "SSTR5", "organism": "Bovine", "refseq_name": "somatostatin receptor type 5", "refseq_ac": [ { "id": "XP_024840990", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840990", "type": "external" } ], "gene_names_uniprotkb": "SSTR5", "gene_names_refseq": "SSTR5", "protein_names_uniprotkb": "Somatostatin receptor type 5; SS-5-R; SS5-R; SS5R", "protein_names_refseq": "somatostatin receptor type 5", "tax_id": 9913, "disease": "", "pathway": " (bta:510344); (R-BTA-375276); (R-BTA-418594)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004994 somatostatin receptor activity;GO:0042923 neuropeptide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0050796 regulation of insulin secretion;GO:0071385 cellular response to glucocorticoid stimulus;GO:0032467 positive regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MV99-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MVK2-1", "uniprot_id": [ { "id": "F1MVK2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MVK2", "type": "external" } ], "mass": 89235.0, "length": 807, "protein_name": "N-terminal kinase-like protein", "gene_name": "SCYL1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SCYL1", "gene_names_refseq": "", "protein_names_uniprotkb": "N-terminal kinase-like protein; SCY1-like protein 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0005801 cis-Golgi network;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment;GO:0030126 COPI vesicle coat", "go_biological_process": "GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MVK2-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MW60-1", "uniprot_id": [ { "id": "F1MW60_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MW60", "type": "external" } ], "mass": 31750.0, "length": 296, "protein_name": "Chronophin", "gene_name": "PDXP", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PDXP", "gene_names_refseq": "", "protein_names_uniprotkb": "Chronophin; 3.1.3.16; 3.1.3.74; Pyridoxal phosphate phosphatase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism. Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0033883 pyridoxal phosphatase activity;GO:0000287 magnesium ion binding;GO:0042803 protein homodimerization activity;GO:0031072 heat shock protein binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005911 cell-cell junction;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0032361 pyridoxal phosphate catabolic process;GO:0007088 regulation of mitotic nuclear division;GO:0032465 regulation of cytokinesis;GO:0030836 positive regulation of actin filament depolymerization;GO:0099159 regulation of modification of postsynaptic structure", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MW60-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MWH3-1", "uniprot_id": [ { "id": "F1MWH3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MWH3", "type": "external" } ], "mass": 57817.0, "length": 503, "protein_name": "steroid 11beta-monooxygenase", "gene_name": "CYP11B1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CYP11B1", "gene_names_refseq": "", "protein_names_uniprotkb": "steroid 11beta-monooxygenase; 1.14.15.4; Cytochrome P450C11", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-193993); (R-BTA-194002); (R-BTA-211976)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.15.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.4", "type": "external" }, { "id": "1.14.15.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.5", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004507 steroid 11-beta-monooxygenase activity;GO:0047783 corticosterone 18-monooxygenase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0006704 glucocorticoid biosynthetic process;GO:0071375 cellular response to peptide hormone stimulus;GO:0032342 aldosterone biosynthetic process;GO:0034650 cortisol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MWH3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MWI8-1", "uniprot_id": [ { "id": "F1MWI8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MWI8", "type": "external" } ], "mass": 111449.0, "length": 1028, "protein_name": "Glutamate receptor", "gene_name": "GRIN3B", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GRIN3B", "gene_names_refseq": "", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005262 calcium channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0008066 glutamate receptor activity;GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0017146 NMDA selective glutamate receptor complex;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0035235 ionotropic glutamate receptor signaling pathway;GO:0035249 synaptic transmission, glutamatergic;GO:0048167 regulation of synaptic plasticity;GO:0051924 regulation of calcium ion transport;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MWI8-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MWS3-1", "uniprot_id": [ { "id": "F1MWS3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MWS3", "type": "external" } ], "mass": 42989.0, "length": 391, "protein_name": "Gastricsin", "gene_name": "PGC", "organism": "Bovine", "refseq_name": "gastricsin precursor", "refseq_ac": [ { "id": "NP_001192720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192720", "type": "external" } ], "gene_names_uniprotkb": "PGC", "gene_names_refseq": "PGC", "protein_names_uniprotkb": "Gastricsin; 3.4.23.3", "protein_names_refseq": "gastricsin precursor; progastricsin (pepsinogen C)", "tax_id": 9913, "disease": "", "pathway": " (bta:514502)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes a variety of proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0007586 digestion;GO:0002803 positive regulation of antibacterial peptide production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MWS3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MWW8-1", "uniprot_id": [ { "id": "F1MWW8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MWW8", "type": "external" } ], "mass": 97991.0, "length": 892, "protein_name": "Transmembrane protease serine 6", "gene_name": "TMPRSS6", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TMPRSS6", "gene_names_refseq": "", "protein_names_uniprotkb": "Transmembrane protease serine 6; Matriptase-2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1442490); (R-BTA-1474228)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0016485 protein processing;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006879 intracellular iron ion homeostasis;GO:0033619 membrane protein proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MWW8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MXD8-1", "uniprot_id": [ { "id": "F1MXD8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MXD8", "type": "external" } ], "mass": 80182.0, "length": 699, "protein_name": "Polyunsaturated fatty acid lipoxygenase ALOX15", "gene_name": "ALOX12B", "organism": "Bovine", "refseq_name": "arachidonate 12-lipoxygenase, 12R-type", "refseq_ac": [ { "id": "NP_001178967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178967", "type": "external" } ], "gene_names_uniprotkb": "ALOX12B", "gene_names_refseq": "ALOX12B", "protein_names_uniprotkb": "Polyunsaturated fatty acid lipoxygenase ALOX15; 1.13.11.12; 12/15-lipoxygenase; Arachidonate 12-lipoxygenase, leukocyte-type; Arachidonate 15-lipoxygenase; Arachidonate omega-6 lipoxygenase; Erythroid cell-specific 15-lipoxygenase; Hepoxilin A3 synthase Alox15; Linoleate 13S-lipoxygenase", "protein_names_refseq": "arachidonate 12-lipoxygenase, 12R-type", "tax_id": 9913, "disease": "", "pathway": " (bta:504803); (R-BTA-2142712)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "1.13.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.31", "type": "external" }, { "id": "1.13.11.33", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.33", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0008289 lipid binding;GO:0004052 arachidonate 12(S)-lipoxygenase activity;GO:0016165 linoleate 13S-lipoxygenase activity;GO:1990136 linoleate 9S-lipoxygenase activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0034440 lipid oxidation;GO:0010628 positive regulation of gene expression;GO:0043410 positive regulation of MAPK cascade;GO:0046513 ceramide biosynthetic process;GO:0061436 establishment of skin barrier", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MXD8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MXJ1-1", "uniprot_id": [ { "id": "F1MXJ1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MXJ1", "type": "external" } ], "mass": 32184.0, "length": 288, "protein_name": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase", "gene_name": "HACD1", "organism": "Bovine", "refseq_name": "very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 isoform X1", "refseq_ac": [ { "id": "XP_002692150", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692150", "type": "external" } ], "gene_names_uniprotkb": "HACD1", "gene_names_refseq": "HACD1", "protein_names_uniprotkb": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; 4.2.1.134", "protein_names_refseq": "very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:615191); (R-BTA-75876)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.134", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.134", "type": "external" } ], "go_molecular_function": "GO:0018812 3-hydroxyacyl-CoA dehydratase activity;GO:0102158 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0030497 fatty acid elongation;GO:0042761 very long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MXJ1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MXJ5-1", "uniprot_id": [ { "id": "F1MXJ5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MXJ5", "type": "external" } ], "mass": 39825.0, "length": 364, "protein_name": "IST1 homolog", "gene_name": "IST1", "organism": "Bovine", "refseq_name": "IST1 homolog isoform X1", "refseq_ac": [ { "id": "XP_005218560", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218560", "type": "external" } ], "gene_names_uniprotkb": "IST1", "gene_names_refseq": "CHMP8; IST1", "protein_names_uniprotkb": "IST1 homolog; Charged multivesicular body protein 8", "protein_names_refseq": "IST1 homolog isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-6798695); (R-BTA-9668328)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation. Is required for efficient abscission during cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2. Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0090541 MIT domain binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005813 centrosome;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle;GO:0000785 chromatin", "go_biological_process": "GO:0015031 protein transport;GO:0008104 intracellular protein localization;GO:0045862 positive regulation of proteolysis;GO:0061952 midbody abscission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MXJ5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MXM6-1", "uniprot_id": [ { "id": "F1MXM6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MXM6", "type": "external" } ], "mass": 44978.0, "length": 406, "protein_name": "Growth/differentiation factor 11", "gene_name": "GDF11", "organism": "Bovine", "refseq_name": "growth/differentiation factor 11", "refseq_ac": [ { "id": "XP_002687467", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687467", "type": "external" } ], "gene_names_uniprotkb": "GDF11", "gene_names_refseq": "GDF11", "protein_names_uniprotkb": "Growth/differentiation factor 11; Bone morphogenetic protein 11", "protein_names_refseq": "growth/differentiation factor 11", "tax_id": 9913, "disease": "", "pathway": " (bta:540517)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues. It is required for proper vertebral patterning and orofacial development. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0032924 activin receptor signaling pathway;GO:0060391 positive regulation of SMAD protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MXM6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MXQ1-1", "uniprot_id": [ { "id": "F1MXQ1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MXQ1", "type": "external" } ], "mass": 33489.0, "length": 324, "protein_name": "Homeobox protein engrailed-like", "gene_name": "EN2", "organism": "Bovine", "refseq_name": "homeobox protein engrailed-2", "refseq_ac": [ { "id": "XP_024847060", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847060", "type": "external" } ], "gene_names_uniprotkb": "EN2", "gene_names_refseq": "EN2", "protein_names_uniprotkb": "Homeobox protein engrailed-like", "protein_names_refseq": "homeobox protein engrailed-2", "tax_id": 9913, "disease": "", "pathway": " (bta:100337304)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0043524 negative regulation of neuron apoptotic process;GO:0030182 neuron differentiation;GO:1990403 embryonic brain development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MXQ1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MXT1-1", "uniprot_id": [ { "id": "F1MXT1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MXT1", "type": "external" } ], "mass": 35626.0, "length": 324, "protein_name": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase", "gene_name": "HACD2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HACD2", "gene_names_refseq": "", "protein_names_uniprotkb": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; 4.2.1.134", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-75876)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.134", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.134", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0018812 3-hydroxyacyl-CoA dehydratase activity;GO:0102158 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0030497 fatty acid elongation;GO:0042761 very long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MXT1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MXW1-1", "uniprot_id": [ { "id": "F1MXW1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MXW1", "type": "external" } ], "mass": 64379.0, "length": 590, "protein_name": "Cytochrome P450 2W1", "gene_name": "CYP2W1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CYP2W1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 2W1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-211958); (R-BTA-211981)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.-", "type": "external" } ], "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0005506 iron ion binding;GO:0005503 all-trans retinal binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005788 endoplasmic reticulum lumen;GO:0009986 cell surface", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0006644 phospholipid metabolic process;GO:0006082 organic acid metabolic process;GO:0034653 retinoic acid catabolic process;GO:0046222 aflatoxin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MXW1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MXW4-1", "uniprot_id": [ { "id": "F1MXW4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MXW4", "type": "external" } ], "mass": 114236.0, "length": 1034, "protein_name": "Sodium/potassium-transporting ATPase subunit alpha", "gene_name": "ATP4A", "organism": "Bovine", "refseq_name": "potassium-transporting ATPase alpha chain 1", "refseq_ac": [ { "id": "NP_001137561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137561", "type": "external" } ], "gene_names_uniprotkb": "ATP4A", "gene_names_refseq": "ATP4A", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit alpha", "protein_names_refseq": "ATPase H+/K+ transporting alpha subunit; ATPase, H+/K+ exchanging, alpha polypeptide; potassium-transporting ATPase alpha chain 1", "tax_id": 9913, "disease": "", "pathway": " (bta:521163); (R-BTA-936837)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric lumen while transporting K(+) ion from the lumen into the cell. Remarkably generates a million-fold proton gradient across the gastric parietal cell membrane, acidifying the gastric juice down to pH 1. Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). The release of the H(+) ion in the stomach lumen is followed by binding of K(+) ion converting the pump conformation back to the E1 state., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0005391 P-type sodium:potassium-exchanging transporter activity;GO:0008900 P-type potassium:proton transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006883 intracellular sodium ion homeostasis;GO:0030007 intracellular potassium ion homeostasis;GO:0036376 sodium ion export across plasma membrane;GO:1990573 potassium ion import across plasma membrane;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MXW4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MXW5-1", "uniprot_id": [ { "id": "F1MXW5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MXW5", "type": "external" } ], "mass": 48587.0, "length": 460, "protein_name": "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial", "gene_name": "OXSM", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "OXSM", "gene_names_refseq": "", "protein_names_uniprotkb": "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; 2.3.1.41", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-9837999)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.1.1.100", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100", "type": "external" }, { "id": "1.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.39", "type": "external" }, { "id": "2.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.38", "type": "external" }, { "id": "2.3.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.39", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "2.3.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.85", "type": "external" }, { "id": "3.1.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14", "type": "external" }, { "id": "4.2.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.59", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" } ], "go_molecular_function": "GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006637 acyl-CoA metabolic process;GO:0006633 fatty acid biosynthetic process;GO:0051792 medium-chain fatty acid biosynthetic process;GO:0051790 short-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MXW5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MXY2-1", "uniprot_id": [ { "id": "F1MXY2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MXY2", "type": "external" } ], "mass": 17591.0, "length": 155, "protein_name": "Microsomal glutathione S-transferase 1", "gene_name": "MGST1", "organism": "Bovine", "refseq_name": "microsomal glutathione S-transferase 1 isoform X1", "refseq_ac": [ { "id": "XP_005207031", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207031", "type": "external" } ], "gene_names_uniprotkb": "MGST1", "gene_names_refseq": "MGST1", "protein_names_uniprotkb": "Microsomal glutathione S-transferase 1; 2.5.1.18", "protein_names_refseq": "microsomal glutathione S-transferase 1 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-156590); (R-BTA-5423646); (R-BTA-6798695)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "4.1.1.84", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.84", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "2.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0004602 glutathione peroxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0034635 glutathione transport;GO:0071449 cellular response to lipid hydroperoxide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MXY2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MXY3-1", "uniprot_id": [ { "id": "F1MXY3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MXY3", "type": "external" } ], "mass": 61174.0, "length": 557, "protein_name": "Solute carrier family 22 member 3", "gene_name": "SLC22A3", "organism": "Bovine", "refseq_name": "solute carrier family 22 member 3", "refseq_ac": [ { "id": "XP_002690418", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690418", "type": "external" } ], "gene_names_uniprotkb": "SLC22A3", "gene_names_refseq": "SLC22A3", "protein_names_uniprotkb": "Solute carrier family 22 member 3; Organic cation transporter 3", "protein_names_refseq": "solute carrier family 22 member 3", "tax_id": 9913, "disease": "", "pathway": " (bta:535665); (R-BTA-2161517); (R-BTA-549127)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0015651 quaternary ammonium group transmembrane transporter activity;GO:0008504 monoamine transmembrane transporter activity;GO:0015220 choline transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0031966 mitochondrial membrane;GO:0043025 neuronal cell body;GO:0016324 apical plasma membrane;GO:0098793 presynapse", "go_biological_process": "GO:0015695 organic cation transport;GO:0006811 monoatomic ion transport;GO:0051615 histamine uptake;GO:0090494 dopamine uptake;GO:0051610 serotonin uptake", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MXY3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MXY8-1", "uniprot_id": [ { "id": "F1MXY8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MXY8", "type": "external" } ], "mass": 33780.0, "length": 311, "protein_name": "Tricarboxylate transport protein, mitochondrial", "gene_name": "SLC25A1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SLC25A1", "gene_names_refseq": "", "protein_names_uniprotkb": "Tricarboxylate transport protein, mitochondrial; Citrate transport protein; Solute carrier family 25 member 1; Tricarboxylate carrier protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-428643)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extent trans-aconitate, maleate and succinate. Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction. In the cytoplasm, citrate plays important roles in fatty acid and sterol synthesis, regulation of glycolysis, protein acetylation, and other physiopathological processes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0071913 citrate secondary active transmembrane transporter activity", "go_cellular_component": "GO:0031966 mitochondrial membrane;GO:0005739 mitochondrion", "go_biological_process": "GO:0055085 transmembrane transport;GO:0006843 mitochondrial citrate transmembrane transport;GO:0110076 negative regulation of ferroptosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MXY8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MY02-1", "uniprot_id": [ { "id": "F1MY02_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MY02", "type": "external" } ], "mass": 88591.0, "length": 796, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 1a-like", "gene_name": "LOC112442047", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LOC112442047", "gene_names_refseq": "", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 1a-like", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:1990913 sperm head plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0007339 binding of sperm to zona pellucida;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MY02-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MY91-1", "uniprot_id": [ { "id": "F1MY91_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MY91", "type": "external" } ], "mass": 58529.0, "length": 511, "protein_name": "Matrix metalloproteinase-27", "gene_name": "MMP27", "organism": "Bovine", "refseq_name": "matrix metalloproteinase-27 isoform X1", "refseq_ac": [ { "id": "XP_059730713", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059730713", "type": "external" } ], "gene_names_uniprotkb": "MMP27", "gene_names_refseq": "MMP27", "protein_names_uniprotkb": "Matrix metalloproteinase-27", "protein_names_refseq": "matrix metalloproteinase-27 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MY91-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MYG0-1", "uniprot_id": [ { "id": "F1MYG0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MYG0", "type": "external" } ], "mass": 48118.0, "length": 439, "protein_name": "Ornithine aminotransferase", "gene_name": "OAT", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "OAT", "gene_names_refseq": "", "protein_names_uniprotkb": "Ornithine aminotransferase; 2.6.1.13", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-8964539)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the reversible interconversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.6.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.13", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0004587 ornithine aminotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0055129 L-proline biosynthetic process;GO:0010121 L-arginine catabolic process to proline via ornithine;GO:0019544 L-arginine catabolic process to L-glutamate", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MYG0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MYR0-1", "uniprot_id": [ { "id": "F1MYR0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MYR0", "type": "external" } ], "mass": 119509.0, "length": 1089, "protein_name": "Histone deacetylase", "gene_name": "HDAC4", "organism": "Bovine", "refseq_name": "histone deacetylase 4 isoform X4", "refseq_ac": [ { "id": "XP_059741237", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059741237", "type": "external" } ], "gene_names_uniprotkb": "HDAC4", "gene_names_refseq": "HDAC4", "protein_names_uniprotkb": "Histone deacetylase; 3.5.1.98", "protein_names_refseq": "histone deacetylase 4 isoform X4", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-350054); (R-BTA-4090294); (R-BTA-4551638); (R-BTA-8951936)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0031594 neuromuscular junction;GO:0042641 actomyosin;GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0014894 response to denervation involved in regulation of muscle adaptation;GO:0045820 negative regulation of glycolytic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MYR0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N758-1", "uniprot_id": [ { "id": "F1N758_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N758", "type": "external" } ], "mass": 146850.0, "length": 1308, "protein_name": "Receptor protein-tyrosine kinase", "gene_name": "ERBB4", "organism": "Bovine", "refseq_name": "receptor tyrosine-protein kinase erbB-4 isoform X2", "refseq_ac": [ { "id": "XP_010800592", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010800592", "type": "external" } ], "gene_names_uniprotkb": "ERBB4", "gene_names_refseq": "ERBB4", "protein_names_uniprotkb": "Receptor protein-tyrosine kinase; 2.7.10.1", "protein_names_refseq": "receptor tyrosine-protein kinase erbB-4 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:522419); (R-BTA-1227986); (R-BTA-1236394); (R-BTA-1250196); (R-BTA-1250342); (R-BTA-1250347); (R-BTA-1251985); (R-BTA-1253288); (R-BTA-1257604); (R-BTA-1963640); (R-BTA-1963642); (R-BTA-5673001); (R-BTA-6785631); (R-BTA-6811558); (R-BTA-8847993); (R-BTA-8863795); (R-BTA-9018519)", "pathway_count": 17, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" } ], "go_molecular_function": "GO:0038131 neuregulin receptor activity;GO:0005524 ATP binding;GO:0005154 epidermal growth factor receptor binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009925 basal plasma membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0043066 negative regulation of apoptotic process;GO:0043410 positive regulation of MAPK cascade;GO:0006915 apoptotic process;GO:0007173 epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N758-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6RBM0-1", "uniprot_id": [ { "id": "F6RBM0_BOVIN", "url": "https://www.uniprot.org/uniprot/F6RBM0", "type": "external" } ], "mass": 41896.0, "length": 370, "protein_name": "Very-long-chain 3-oxoacyl-CoA reductase", "gene_name": "HSD17B12", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HSD17B12", "gene_names_refseq": "", "protein_names_uniprotkb": "Very-long-chain 3-oxoacyl-CoA reductase; 1.1.1.330; 1.1.1.62; 17-beta-hydroxysteroid dehydrogenase 12; 3-ketoacyl-CoA reductase; Estradiol 17-beta-dehydrogenase 12", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "1.1.1.n12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12", "type": "external" }, { "id": "1.1.1.330", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.330", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.357", "type": "external" }, { "id": "1.1.1.188", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.188", "type": "external" }, { "id": "1.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.64", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" }, { "id": "1.1.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.225", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.51", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.270", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270", "type": "external" } ], "go_molecular_function": "GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0141040 very-long-chain 3-oxoacyl-CoA reductase activity;GO:0008201 heparin binding;GO:0005518 collagen binding;GO:0001968 fibronectin binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0031012 extracellular matrix;GO:0009923 fatty acid elongase complex", "go_biological_process": "GO:0006694 steroid biosynthetic process;GO:0006702 androgen biosynthetic process;GO:0006703 estrogen biosynthetic process;GO:0019367 fatty acid elongation, saturated fatty acid", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6RBM0-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48617-1", "uniprot_id": [ { "id": "EPO_BOVIN", "url": "https://www.uniprot.org/uniprot/P48617", "type": "external" } ], "mass": 21076.0, "length": 192, "protein_name": "Erythropoietin", "gene_name": "EPO", "organism": "Bovine", "refseq_name": "erythropoietin precursor", "refseq_ac": [ { "id": "NP_776334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776334", "type": "external" } ], "gene_names_uniprotkb": "EPO", "gene_names_refseq": "EPO", "protein_names_uniprotkb": "Erythropoietin", "protein_names_refseq": "erythropoietin precursor", "tax_id": 9913, "disease": "", "pathway": " (biu:109578290); (bta:280784); (R-BTA-9027276); (R-BTA-9027284)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "8666286", "class_list": "", "function": "Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "A3FFT0", "ec_number_list": [], "go_molecular_function": "GO:0030295 protein kinase activator activity;GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0005128 erythropoietin receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0043249 erythrocyte maturation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0030218 erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P48617-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49004-1", "uniprot_id": [ { "id": "DPOD2_BOVIN", "url": "https://www.uniprot.org/uniprot/P49004", "type": "external" } ], "mass": 50997.0, "length": 469, "protein_name": "DNA polymerase delta subunit 2", "gene_name": "POLD2", "organism": "Bovine", "refseq_name": "DNA polymerase delta subunit 2", "refseq_ac": [ { "id": "NP_776853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776853", "type": "external" } ], "gene_names_uniprotkb": "POLD2", "gene_names_refseq": "POLD2", "protein_names_uniprotkb": "DNA polymerase delta subunit 2; DNA polymerase delta subunit p50", "protein_names_refseq": "DAN polymerase delta 2, accessory subunit; DNA polymerase delta subunit 2; DNA polymerase delta subunit p50; polymerase (DNA directed), delta 2, accessory subunit; polymerase (DNA directed), delta 2, regulatory subunit 50kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:281991); (R-BTA-110314); (R-BTA-174411); (R-BTA-174414); (R-BTA-174417); (R-BTA-174437); (R-BTA-5358565); (R-BTA-5358606); (R-BTA-5651801); (R-BTA-5656169); (R-BTA-5685942); (R-BTA-5693537); (R-BTA-5696397); (R-BTA-5696400); (R-BTA-6782135); (R-BTA-6782210); (R-BTA-69091); (R-BTA-69166); (R-BTA-69183)", "pathway_count": 19, "publication_count": 2, "publication_id_list": "10751307;8530069", "class_list": "", "function": "Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex. As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4. Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the DNA polymerase zeta complex. Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q29RZ3", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0043625 delta DNA polymerase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016035 zeta DNA polymerase complex", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006271 DNA strand elongation involved in DNA replication;GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0042276 error-prone translesion synthesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P49004-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MWI1-1", "uniprot_id": [ { "id": "G3MWI1_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MWI1", "type": "external" } ], "mass": 135364.0, "length": 1212, "protein_name": "Anion exchange protein", "gene_name": "SLC4A7", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SLC4A7", "gene_names_refseq": "", "protein_names_uniprotkb": "Anion exchange protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:510209); (R-BTA-425381); (R-BTA-9013406); (R-BTA-9013407); (R-BTA-9035034)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, 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solute:inorganic anion antiporter activity;GO:0015106 bicarbonate transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015701 bicarbonate transport;GO:0051453 regulation of intracellular pH;GO:0060117 auditory receptor cell development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3MWI1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N734-1", "uniprot_id": [ { "id": "F1N734_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N734", "type": "external" } ], "mass": 304952.0, "length": 2721, "protein_name": "Chromodomain helicase DNA binding protein 6", "gene_name": "CHD6", "organism": "Bovine", "refseq_name": "ATP-dependent chromatin remodeler CHD6", "refseq_ac": [ { "id": "NP_001230229", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230229", "type": "external" } ], "gene_names_uniprotkb": "CHD6", "gene_names_refseq": "CHD6", "protein_names_uniprotkb": "Chromodomain helicase DNA binding protein 6", "protein_names_refseq": "ATP-dependent chromatin remodeler CHD6", "tax_id": 9913, "disease": "", "pathway": " (bta:524776); (R-BTA-9943962)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0008094 ATP-dependent activity, acting on DNA;GO:0001221 transcription coregulator binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization;GO:0045454 cell redox homeostasis;GO:0006338 chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N734-1", "record_type": "protein", "filter_code": "0000000.0000001.001000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O19137-1", "uniprot_id": [ { "id": "CPSF4_BOVIN", "url": "https://www.uniprot.org/uniprot/O19137", "type": "external" } ], "mass": 27422.0, "length": 243, "protein_name": "Cleavage and polyadenylation specificity factor subunit 4", "gene_name": "CPSF4", "organism": "Bovine", "refseq_name": "cleavage and polyadenylation specificity factor subunit 4", "refseq_ac": [ { "id": "NP_776367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776367", "type": "external" } ], "gene_names_uniprotkb": "CPSF4; CPSF30", "gene_names_refseq": "CPSF4; NAR", "protein_names_uniprotkb": "Cleavage and polyadenylation specificity factor subunit 4; CPSF 30 kDa subunit; Cleavage and polyadenylation specificity factor 30 kDa subunit", "protein_names_refseq": "CPSF 30 kDa subunit; cleavage and polyadenylation specific factor 4, 30kDa; cleavage and polyadenylation specificity factor 30 kDa subunit; cleavage and polyadenylation specificity factor subunit 4; cleavage-polyadenylation specificity factor, 30 kD", "tax_id": 9913, "disease": "", "pathway": " (bta:280875); (R-BTA-159231); (R-BTA-73856); (R-BTA-77595); (R-BTA-9770562)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "9224719", "class_list": "", "function": "Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005847 mRNA cleavage and polyadenylation specificity factor complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O19137-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61603-1", "uniprot_id": [ { "id": "CH10_BOVIN", "url": "https://www.uniprot.org/uniprot/P61603", "type": "external" } ], "mass": 10932.0, "length": 102, "protein_name": "10 kDa heat shock protein, mitochondrial", "gene_name": "HSPE1", "organism": "Bovine", "refseq_name": "10 kDa heat shock protein, mitochondrial", "refseq_ac": [ { "id": "NP_776771", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776771", "type": "external" } ], "gene_names_uniprotkb": "HSPE1", "gene_names_refseq": "HSPE1", "protein_names_uniprotkb": "10 kDa heat shock protein, mitochondrial; 10 kDa chaperonin; CPN10; Chaperonin 10; Hsp10", "protein_names_refseq": "10 kDa chaperonin; 10 kDa heat shock protein, mitochondrial; CPN10; chaperonin 10; heat shock 10kDa protein 1 (chaperonin 10); hsp10", "tax_id": 9913, "disease": "", "pathway": " (bta:281833); (R-BTA-9013408)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8104547", "class_list": "", "function": "Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O95421;Q04984;Q3SZV9", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P61603-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02316-1", "uniprot_id": [ { "id": "HMGN1_BOVIN", "url": "https://www.uniprot.org/uniprot/P02316", "type": "external" } ], "mass": 10831.0, "length": 101, "protein_name": "Non-histone chromosomal protein HMG-14", "gene_name": "HMGN1", "organism": "Bovine", "refseq_name": "non-histone chromosomal protein HMG-14", "refseq_ac": [ { "id": "NP_001029944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029944", "type": "external" } ], "gene_names_uniprotkb": "HMGN1; HMG14", "gene_names_refseq": "HMGN1", "protein_names_uniprotkb": "Non-histone chromosomal protein HMG-14; High mobility group nucleosome-binding domain-containing protein 1", "protein_names_refseq": "high mobility group nucleosome-binding domain-containing protein 1; non-histone chromosomal protein HMG-14", "tax_id": 9913, "disease": "", "pathway": " (bta:614915)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "456580", "class_list": "", "function": "Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0D1", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0031492 nucleosomal DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P02316-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15246-1", "uniprot_id": [ { "id": "PIMT_BOVIN", "url": "https://www.uniprot.org/uniprot/P15246", "type": "external" } ], "mass": 24565.0, "length": 227, "protein_name": "Protein-L-isoaspartate(D-aspartate) O-methyltransferase", "gene_name": "PCMT1", "organism": "Bovine", "refseq_name": "protein-L-isoaspartate(D-aspartate) O-methyltransferase", "refseq_ac": [ { "id": "NP_001073085", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073085", "type": "external" } ], "gene_names_uniprotkb": "PCMT1", "gene_names_refseq": "PCMT1", "protein_names_uniprotkb": "Protein-L-isoaspartate(D-aspartate) O-methyltransferase; 2.1.1.77; L-isoaspartyl protein carboxyl methyltransferase; PIMT; Protein L-isoaspartyl/D-aspartyl methyltransferase; Protein-beta-aspartate methyltransferase", "protein_names_refseq": "L-isoaspartyl protein carboxyl methyltransferase; PIMT; protein L-isoaspartyl/D-aspartyl methyltransferase; protein-L-isoaspartate(D-aspartate) O-methyltransferase; protein-beta-aspartate methyltransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:613854); (R-BTA-5676934)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "1627573;2777770;3167043", "class_list": "", "function": "Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins (By similarity). Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32LB2", "ec_number_list": [ { "id": "2.1.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.77", "type": "external" } ], "go_molecular_function": "GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006479 protein methylation;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P15246-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C2B7-1", "uniprot_id": [ { "id": "RM52_BOVIN", "url": "https://www.uniprot.org/uniprot/P0C2B7", "type": "external" } ], "mass": 13813.0, "length": 124, "protein_name": "Large ribosomal subunit protein mL52", "gene_name": "MRPL52", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein mL52 precursor", "refseq_ac": [ { "id": "NP_001103650", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103650", "type": "external" } ], "gene_names_uniprotkb": "MRPL52", "gene_names_refseq": "MRPL52", "protein_names_uniprotkb": "Large ribosomal subunit protein mL52; 39S ribosomal protein L52, mitochondrial; L52mt; MRP-L52", "protein_names_refseq": "39S ribosomal protein L52, mitochondrial; L52mt; MRP-L52; large ribosomal subunit protein mL52 precursor; large ribosomal subunit protein mL52", "tax_id": 9913, "disease": "", "pathway": " (bta:509469); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "11551941", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8YXY0", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C2B7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15783-1", "uniprot_id": [ { "id": "PSPC_BOVIN", "url": "https://www.uniprot.org/uniprot/P15783", "type": "external" } ], "mass": 20440.0, "length": 190, "protein_name": "Surfactant protein C", "gene_name": "SFTPC", "organism": "Bovine", "refseq_name": "surfactant protein C", "refseq_ac": [ { "id": "NP_776887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776887", "type": "external" } ], "gene_names_uniprotkb": "SFTPC; SFTP2", "gene_names_refseq": "SFTPC", "protein_names_uniprotkb": "Surfactant protein C; Pulmonary surfactant-associated protein C; Pulmonary surfactant-associated proteolipid SPL(Val); SP-C", "protein_names_refseq": "SP-C; pulmonary surfactant-associated protein C; pulmonary surfactant-associated proteolipid SPL(Val); surfactant protein C; surfactant, pulmonary-associated protein C", "tax_id": 9913, "disease": "", "pathway": " (bta:282071); (R-BTA-5683826)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "1872406;20409474;3366248;3663690;3689402", "class_list": "", "function": "Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The hydrophobic surfactant proteins SP-B and SP-C induce formation of bicontinuous inverse cubic phases., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4FV06;P15784;Q9BDX5", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0097208 alveolar lamellar body;GO:0005576 extracellular region", "go_biological_process": "GO:0007585 respiratory gaseous exchange by respiratory system", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P15783-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25712-1", "uniprot_id": [ { "id": "NDUV3_BOVIN", "url": "https://www.uniprot.org/uniprot/P25712", "type": "external" } ], "mass": 11857.0, "length": 109, "protein_name": "NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial", "gene_name": "NDUFV3", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform 3", "refseq_ac": [ { "id": "NP_787024", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787024", "type": "external" } ], "gene_names_uniprotkb": "NDUFV3", "gene_names_refseq": "NDUFV3", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial; CI-9kD; Complex I-9kD; NADH-ubiquinone oxidoreductase 9 kDa subunit", "protein_names_refseq": "CI-9kD; NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform 3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial; NADH-ubiquinone oxidoreductase 9 kDa subunit; complex I-9kD", "tax_id": 9913, "disease": "", "pathway": " (bta:327717)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1778979;18721790;1902801;27988283", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Further mass spectrometric analyses of complex I from different murine and bovine tissues showed a tissue-specific expression pattern of NDUFV3-S and NDUFV3-L. Hence, NDUFV3-S was identified as the only isoform in heart and skeletal muscle, whereas in liver, brain, and lung NDUFV3-L was expressed as the dominant isoform, together with NDUFV3-S present in all tissues analyzed, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZ08", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0042775 mitochondrial ATP synthesis coupled electron transport;GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P25712-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N1W2-1", "uniprot_id": [ { "id": "F1N1W2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N1W2", "type": "external" } ], "mass": 47344.0, "length": 419, "protein_name": "Kinase", "gene_name": "IPMK", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "IPMK", "gene_names_refseq": "", "protein_names_uniprotkb": "Kinase; 2.7.-.-", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1855191)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity;GO:0000825 inositol-1,3,4,5-tetrakisphosphate 6-kinase activity;GO:0097243 flavonoid binding;GO:0047326 inositol-1,3,4,6-tetrakisphosphate 5-kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0070266 necroptotic process;GO:0032957 inositol trisphosphate metabolic process;GO:0032958 inositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N1W2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6R2C4-1", "uniprot_id": [ { "id": "F6R2C4_BOVIN", "url": "https://www.uniprot.org/uniprot/F6R2C4", "type": "external" } ], "mass": 25028.0, "length": 229, "protein_name": "Apoptosis regulator Bcl-2", "gene_name": "BCL2", "organism": "Bovine", "refseq_name": "apoptosis regulator Bcl-2", "refseq_ac": [ { "id": "NP_001159958", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159958", "type": "external" } ], "gene_names_uniprotkb": "BCL2", "gene_names_refseq": "BCL2", "protein_names_uniprotkb": "Apoptosis regulator Bcl-2", "protein_names_refseq": "B-cell CLL/lymphoma 2; apoptosis regulator Bcl-2", "tax_id": 9913, "disease": "", "pathway": " (bta:281020); (R-BTA-111447); (R-BTA-111453); (R-BTA-844455)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "14519654;14633857;15068062;18272300;18584328;24085451;24962416", "class_list": "", "function": "Apoptosis-inducing factor was expressed in luminal alveolar cells and, in concert with a change in bax protein to bcl-2 protein ratio, might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses, [RefSeq, PubMed]; BoHV-5 replication apparently modulates BCL-2 expression and gene transcription, enhancing production of virus progeny, but does not increase Bax expression. Publication Status: Online-Only, [RefSeq, PubMed]; G3139, a BCL-2 antisesnse oligonucleotide is a promising candidate for treatment of patients with imatinib-resistant Ph-positive leukemia., [RefSeq, PubMed]; MRNA expression of Bax, Bcl-2, caspase-3 and-7 cannot be used as a reliable apoptosis detection method., [RefSeq, PubMed]; Over-expression of STC-1 up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 production in the damaged cells. Findings from this study suggest that STC-1 plays a protective role in intestinal cells through an antioxidant mechanism., [RefSeq, PubMed]; Role of vascular endothelial growth factor receptor-1 in Bcl-2 expression, [RefSeq, PubMed]; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function. May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results propose an additional mechanism whereby resveratrol may exert its cardioprotective effects and suggest a key role for Bcl-2 in the resveratrol anti-apoptotic action, especially in disrupting peroxynitrite-triggered mitochondrial pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0002020 protease binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005829 cytosol;GO:0043209 myelin sheath", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0006914 autophagy;GO:0035094 response to nicotine;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "F6R2C4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6PRJ0-1", "uniprot_id": [ { "id": "F6PRJ0_BOVIN", "url": "https://www.uniprot.org/uniprot/F6PRJ0", "type": "external" } ], "mass": 90217.0, "length": 796, "protein_name": "Volume-regulated anion channel subunit LRRC8E", "gene_name": "LRRC8E", "organism": "Bovine", "refseq_name": "volume-regulated anion channel subunit LRRC8E", "refseq_ac": [ { "id": "NP_001192551", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192551", "type": "external" } ], "gene_names_uniprotkb": "LRRC8E", "gene_names_refseq": "LRRC8E", "protein_names_uniprotkb": "Volume-regulated anion channel subunit LRRC8E; 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"go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction;GO:0006198 cAMP catabolic process;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N5T6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X6Y8-1", "uniprot_id": [ { "id": "G3X6Y8_BOVIN", "url": "https://www.uniprot.org/uniprot/G3X6Y8", "type": "external" } ], "mass": 53241.0, "length": 495, "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 8", "gene_name": "ENTPD8", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENTPD8", "gene_names_refseq": "", "protein_names_uniprotkb": "Ectonucleoside triphosphate diphosphohydrolase 8; 3.6.1.5", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-8850843)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.16", "type": "external" }, { "id": "3.6.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.53", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0017110 nucleoside diphosphate phosphatase activity;GO:0017111 ribonucleoside triphosphate phosphatase activity;GO:0004050 apyrase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0009203 ribonucleoside triphosphate catabolic process;GO:0009191 ribonucleoside diphosphate catabolic process;GO:0009134 nucleoside diphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3X6Y8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13135-1", "uniprot_id": [ { "id": "CPNS1_BOVIN", "url": "https://www.uniprot.org/uniprot/P13135", "type": "external" } ], "mass": 27931.0, "length": 263, "protein_name": "Calpain small subunit 1", "gene_name": "CAPNS1", "organism": "Bovine", "refseq_name": "calpain small subunit 1", "refseq_ac": [ { "id": "NP_776686", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776686", "type": "external" } ], "gene_names_uniprotkb": "CAPNS1; CAPN4", "gene_names_refseq": "CAPN4; CAPNS1", "protein_names_uniprotkb": "Calpain small subunit 1; CANP small subunit; CDPS; CSS1; Calcium-activated neutral proteinase small subunit; Calcium-dependent protease small subunit 1; Calcium-dependent protease small subunit; Calpain regulatory subunit", "protein_names_refseq": "CANP small subunit; CDPS; CSS1; calcium-activated neutral proteinase small subunit; calcium-dependent protease small subunit 1; calpain 4, small subunit (30K); calpain II regulatory subunit; calpain regulatory subunit; calpain small subunit 1", "tax_id": 9913, "disease": "", "pathway": " (bta:281664); (R-BTA-1474228); (R-BTA-9856530); (R-BTA-9860927)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "19649723;2551902", "class_list": "", "function": "A new single nucleotide polymorphism was found in the bovine CAPNS1 gene exon 11 coding for the 3'UTR., [RefSeq, PubMed]; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Essential for embryonic development (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1YVU9;Q1JQC3", "ec_number_list": [], "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0110158 calpain complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0012505 endomembrane system", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P13135-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O62827-1", "uniprot_id": [ { "id": "ADML_BOVIN", "url": "https://www.uniprot.org/uniprot/O62827", "type": "external" } ], "mass": 20963.0, "length": 188, "protein_name": "Pro-adrenomedullin", "gene_name": "ADM", "organism": "Bovine", "refseq_name": "pro-adrenomedullin precursor", "refseq_ac": [ { "id": "NP_776313", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776313", "type": "external" } ], "gene_names_uniprotkb": "ADM", "gene_names_refseq": "ADM", "protein_names_uniprotkb": "Pro-adrenomedullin; PAMP; ProAM N-terminal 20 peptide; ProAM-N20", "protein_names_refseq": "pro-adrenomedullin precursor; pro-adrenomedullin", "tax_id": 9913, "disease": "", "pathway": " (bta:280713); (R-BTA-418555); (R-BTA-419812); (R-BTA-9856530)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "11754956;16940707;23849271;28621496;9585168", "class_list": "", "function": "ADM function is mediated by the CALCRL-RAMP2 and CALCRL-RAMP3 receptor complexes with ADM showing the highest potency for the CALCRL-RAMP2 complex., [UniProtKB, UniProtKB]; Adrenomedullin/ADM and proadrenomedullin N-20 terminal peptide/PAMP are peptide hormones that act as potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis., [UniProtKB, UniProtKB]; Data indicate that adrenomedullin mRNA and protein signal were only found in trophoblast binucleate cells (BNCs), whereas those of CRLR, RAMP2 and RAMP3 were detected in cotyledonary villous and caruncular epithelial cells. Publication Status: Online-Only, [RefSeq, PubMed]; Peptide hormone that act as potent hypotensive and vasodilatator agents by inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells. Acts as a ligand for MRGPRX2 receptor in mast cells., [UniProtKB, UniProtKB]; Studied adrenomedullin's (ADM) role in oviductal fluid flow in cattle., [RefSeq, PubMed]; The present study thus showed that neither leptin nor resistin affects the expression of endothelin-1 or adrenomedullin in bovine brain microvascular endothelial cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08DC5;Q95KP0", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity;GO:0031700 adrenomedullin receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0010460 positive regulation of heart rate;GO:0035809 regulation of urine volume;GO:0003073 regulation of systemic arterial blood pressure;GO:1990410 adrenomedullin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O62827-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55906-1", "uniprot_id": [ { "id": "BGH3_BOVIN", "url": "https://www.uniprot.org/uniprot/P55906", "type": "external" } ], "mass": 74408.0, "length": 683, "protein_name": "Transforming growth factor-beta-induced protein ig-h3", "gene_name": "TGFBI", "organism": "Bovine", "refseq_name": "transforming growth factor-beta-induced protein ig-h3 precursor", "refseq_ac": [ { "id": "NP_001192331", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192331", "type": "external" } ], "gene_names_uniprotkb": "TGFBI; BIGH3", "gene_names_refseq": "MP70; MP78; TGFBI", "protein_names_uniprotkb": "Transforming growth factor-beta-induced protein ig-h3; Beta ig-h3; MP70; MP78", "protein_names_refseq": "beta ig-h3; transforming growth factor, beta-induced, 68kDa; transforming growth factor-beta-induced protein ig-h3 precursor; transforming growth factor-beta-induced protein ig-h3", "tax_id": 9913, "disease": "", "pathway": " (bta:539596)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8557636", "class_list": "", "function": "Plays a role in cell adhesion (By similarity). May play a role in cell-collagen interactions (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Plays a role in cell adhesion. May play a role in cell-collagen interactions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A7YWB6", "ec_number_list": [], "go_molecular_function": "GO:0050839 cell adhesion molecule binding;GO:0042802 identical protein binding;GO:0005518 collagen binding;GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0071944 cell periphery;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0007155 cell adhesion;GO:0030198 extracellular matrix organization;GO:0001525 angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P55906-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X7C1-1", "uniprot_id": [ { "id": "G3X7C1_BOVIN", "url": "https://www.uniprot.org/uniprot/G3X7C1", "type": "external" } ], "mass": 52349.0, "length": 459, "protein_name": "Thyroid hormone receptor beta", "gene_name": "THRB", "organism": "Bovine", "refseq_name": "thyroid hormone receptor beta isoform X2", "refseq_ac": [ { "id": "XP_005226240", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226240", "type": "external" } ], "gene_names_uniprotkb": "THRB", "gene_names_refseq": "THRB", "protein_names_uniprotkb": "Thyroid hormone receptor beta", "protein_names_refseq": "thyroid hormone receptor beta isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:788329); (R-BTA-383280); (R-BTA-4090294)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0070324 thyroid hormone binding;GO:0031490 chromatin DNA binding;GO:0004879 nuclear receptor activity", "go_cellular_component": "GO:0016604 nuclear body;GO:0005634 nucleus;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0042789 mRNA transcription by RNA polymerase II;GO:0097067 cellular response to thyroid hormone stimulus;GO:0002157 positive regulation of thyroid hormone receptor signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3X7C1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29104-1", "uniprot_id": [ { "id": "HPCL4_BOVIN", "url": "https://www.uniprot.org/uniprot/P29104", "type": "external" } ], "mass": 22202.0, "length": 191, "protein_name": "Hippocalcin-like protein 4", "gene_name": "HPCAL4", "organism": "Bovine", "refseq_name": "hippocalcin-like protein 4", "refseq_ac": [ { "id": "NP_001092852", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092852", "type": "external" } ], "gene_names_uniprotkb": "HPCAL4", "gene_names_refseq": "HPCAL4", "protein_names_uniprotkb": "Hippocalcin-like protein 4; Neurocalcin-beta", "protein_names_refseq": "hippocalcin-like protein 4; neurocalcin-beta", "tax_id": 9913, "disease": "", "pathway": " (bta:531339)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1527077", "class_list": "", "function": "May be involved in the calcium-dependent regulation of rhodopsin phosphorylation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PKK8", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "", "go_biological_process": "GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P29104-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N4X7-1", "uniprot_id": [ { "id": "F1N4X7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N4X7", "type": "external" } ], "mass": 92058.0, "length": 827, "protein_name": "Suppressor of tumorigenicity 14 protein homolog", "gene_name": "ST14", "organism": "Bovine", "refseq_name": "suppressor of tumorigenicity 14 protein homolog isoform X3", "refseq_ac": [ { "id": "XP_059739025", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059739025", "type": "external" } ], "gene_names_uniprotkb": "ST14", "gene_names_refseq": "ST14", "protein_names_uniprotkb": "Suppressor of tumorigenicity 14 protein homolog; 3.4.21.109; Serine protease 14", "protein_names_refseq": "suppressor of tumorigenicity 14 protein homolog isoform X3", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing. Proteolytically cleaves and therefore activates TMPRSS13., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0030216 keratinocyte differentiation;GO:0030855 epithelial cell differentiation;GO:0048513 animal organ development;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N4X7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MY82-1", "uniprot_id": [ { "id": "G3MY82_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MY82", "type": "external" } ], "mass": 65074.0, "length": 580, "protein_name": "Mucolipin TRP cation channel 1", "gene_name": "MCOLN1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MCOLN1", "gene_names_refseq": "", "protein_names_uniprotkb": "Mucolipin TRP cation channel 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-3295583); (R-BTA-917977)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005261 monoatomic cation channel activity;GO:0072345 NAADP-sensitive calcium-release channel activity;GO:0042802 identical protein binding;GO:0005267 potassium channel activity;GO:0005253 monoatomic anion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0010008 endosome membrane;GO:0043235 receptor complex;GO:0005765 lysosomal membrane;GO:0005770 late endosome", "go_biological_process": "GO:0090382 phagosome maturation;GO:0051289 protein homotetramerization;GO:0071277 cellular response to calcium ion;GO:0071467 cellular response to pH;GO:0006882 intracellular zinc ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3MY82-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N076-1", "uniprot_id": [ { "id": "F1N076_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N076", "type": "external" } ], "mass": 120779.0, "length": 1060, "protein_name": "Ceruloplasmin", "gene_name": "CP", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CP", "gene_names_refseq": "", "protein_names_uniprotkb": "Ceruloplasmin; 1.11.1.27; 1.11.1.9; 1.16.3.1; 1.16.3.4; Cuproxidase ceruloplasmin; Ferroxidase ceruloplasmin; Glutathione peroxidase ceruloplasmin; Glutathione-dependent peroxiredoxin ceruloplasmin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-381426); (R-BTA-425410); (R-BTA-8957275); (R-BTA-917937)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols. Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" }, { "id": "1.11.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.12", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" } ], "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0005507 copper ion binding;GO:0004322 ferroxidase activity;GO:0004602 glutathione peroxidase activity;GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0006878 intracellular copper ion homeostasis;GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N076-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MZI7-1", "uniprot_id": [ { "id": "G3MZI7_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MZI7", "type": "external" } ], "mass": 184867.0, "length": 1847, "protein_name": "Collagen type V alpha 1 chain", "gene_name": "COL5A1", "organism": "Bovine", "refseq_name": "collagen alpha-1(V) chain isoform X1", "refseq_ac": [ { "id": "XP_024855494", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855494", "type": "external" } ], "gene_names_uniprotkb": "COL5A1", "gene_names_refseq": "COL5A1", "protein_names_uniprotkb": "Collagen type V alpha 1 chain", "protein_names_refseq": "collagen alpha-1(V) chain isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:100848491); (R-BTA-1442490); (R-BTA-1566977); (R-BTA-1650814); (R-BTA-186797); (R-BTA-2022090); (R-BTA-216083); (R-BTA-3000171); (R-BTA-3000178); (R-BTA-8874081); (R-BTA-8948216)", "pathway_count": 11, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005201 extracellular matrix structural constituent;GO:0008201 heparin binding;GO:0043394 proteoglycan binding;GO:0030020 extracellular matrix structural constituent conferring tensile strength;GO:0048407 platelet-derived growth factor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0005588 collagen type V trimer", "go_biological_process": "GO:0007155 cell adhesion;GO:0030199 collagen fibril organization;GO:0035313 wound healing, spreading of epidermal cells;GO:0043588 skin development;GO:0048705 skeletal system morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3MZI7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N6J0-1", "uniprot_id": [ { "id": "F1N6J0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N6J0", "type": "external" } ], "mass": 92753.0, "length": 825, "protein_name": "Tyrosine-protein kinase receptor", "gene_name": "NTRK3", "organism": "Bovine", "refseq_name": "NT-3 growth factor receptor isoform X8", "refseq_ac": [ { "id": "XP_024837660", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837660", "type": "external" } ], "gene_names_uniprotkb": "NTRK3", "gene_names_refseq": "NTRK3", "protein_names_uniprotkb": "Tyrosine-protein kinase receptor; 2.7.10.1", "protein_names_refseq": "NT-3 growth factor receptor isoform X8", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1257604); (R-BTA-388844); (R-BTA-6811558); (R-BTA-9034013); (R-BTA-9034793); (R-BTA-9603381)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0005030 neurotrophin receptor activity;GO:0002039 p53 binding;GO:0043121 neurotrophin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005730 nucleolus;GO:0043235 receptor complex;GO:0030424 axon", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0048513 animal organ development;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N6J0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N6K7-1", "uniprot_id": [ { "id": "F1N6K7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N6K7", "type": "external" } ], "mass": 246283.0, "length": 2328, "protein_name": "Protein transport protein sec16", "gene_name": "SEC16A", "organism": "Bovine", "refseq_name": "protein transport protein Sec16A isoform X3", "refseq_ac": [ { "id": "XP_002691705", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691705", "type": "external" } ], "gene_names_uniprotkb": "SEC16A", "gene_names_refseq": "SEC16A", "protein_names_uniprotkb": "Protein transport protein sec16", "protein_names_refseq": "protein transport protein Sec16A isoform X3", "tax_id": 9913, "disease": "", "pathway": " (bta:519689); (R-BTA-204005)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site", "go_biological_process": "GO:0015031 protein transport;GO:0016192 vesicle-mediated transport;GO:0007029 endoplasmic reticulum organization;GO:0051668 localization within membrane;GO:0072659 protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N6K7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N1J5-1", "uniprot_id": [ { "id": "F1N1J5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N1J5", "type": "external" } ], "mass": 42716.0, "length": 399, "protein_name": "Centrosomal protein 43", "gene_name": "CEP43", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CEP43", "gene_names_refseq": "", "protein_names_uniprotkb": "Centrosomal protein 43; FGFR1 oncogene partner", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2565942); (R-BTA-380259); (R-BTA-380270); (R-BTA-380284); (R-BTA-380320); (R-BTA-5620912); (R-BTA-8854518)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for anchoring microtubules to the centrosomes. Required for ciliation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0030292 protein tyrosine kinase inhibitor activity", "go_cellular_component": "GO:0005814 centriole;GO:0005634 nucleus;GO:0005813 centrosome;GO:0048471 perinuclear region of cytoplasm;GO:0036064 ciliary basal body", "go_biological_process": "GO:0030030 cell projection organization;GO:0034453 microtubule anchoring;GO:0008284 positive regulation of cell population proliferation;GO:0030307 positive regulation of cell growth;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N1J5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O97681-1", "uniprot_id": [ { "id": "VPP2_BOVIN", "url": "https://www.uniprot.org/uniprot/O97681", "type": "external" } ], "mass": 98010.0, "length": 854, "protein_name": "V-type proton ATPase 116 kDa subunit a 2", "gene_name": "ATP6V0A2; DNAH10", "organism": "Bovine", "refseq_name": "V-type proton ATPase 116 kDa subunit a 2", "refseq_ac": [ { "id": "NP_788810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788810", "type": "external" } ], "gene_names_uniprotkb": "ATP6V0A2; DNAH10; ATP6N1B", "gene_names_refseq": "ATP6V0A2", "protein_names_uniprotkb": "V-type proton ATPase 116 kDa subunit a 2; V-ATPase 116 kDa subunit a 2; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2", "protein_names_refseq": "ATPase, H+ transporting, lysosomal V0 subunit a2; V-ATPase 116 kDa subunit a 2; V-ATPase 116 kDa subunit a2; V-type proton ATPase 116 kDa subunit a 2; V-type proton ATPase 116 kDa subunit a2; V-type proton ATPase 116 kDa subunit a; vacuolar proton translocating ATPase 116 kDa subunit a; vacuolar proton translocating ATPase 116-kDa subunit a2", "tax_id": 9913, "disease": "", "pathway": " (bta:100847550); (bta:338038); (R-BTA-1222556); (R-BTA-77387); (R-BTA-917977); (R-BTA-983712)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "30573663;39743588;9891027", "class_list": "", "function": "Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Essential component of the endosomal pH-sensing machinery (By similarity). May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0008569 minus-end-directed microtubule motor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001669 acrosomal vesicle;GO:0010008 endosome membrane;GO:0016471 vacuolar proton-transporting V-type ATPase complex;GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0036295 cellular response to increased oxygen levels;GO:0007035 vacuolar acidification;GO:0007018 microtubule-based movement;GO:0060294 cilium movement involved in cell motility", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O97681-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6PVF9-1", "uniprot_id": [ { "id": "F6PVF9_BOVIN", "url": "https://www.uniprot.org/uniprot/F6PVF9", "type": "external" } ], "mass": 29408.0, "length": 257, "protein_name": "Derlin", "gene_name": "DERL2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DERL2", "gene_names_refseq": "", "protein_names_uniprotkb": "Derlin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-382556); (R-BTA-5358346); (R-BTA-9931269)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005047 signal recognition particle binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005769 early endosome;GO:0005770 late endosome", "go_biological_process": "GO:0010498 proteasomal protein catabolic process;GO:0033554 cellular response to stress;GO:0008284 positive regulation of cell population proliferation;GO:0030307 positive regulation of cell growth;GO:0030968 endoplasmic reticulum unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6PVF9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56652-1", "uniprot_id": [ { "id": "ITIH3_BOVIN", "url": "https://www.uniprot.org/uniprot/P56652", "type": "external" } ], "mass": 99551.0, "length": 891, "protein_name": "Inter-alpha-trypsin inhibitor heavy chain H3", "gene_name": "ITIH3", "organism": "Bovine", "refseq_name": "inter-alpha-trypsin inhibitor heavy chain H3 precursor", "refseq_ac": [ { "id": "NP_001095368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095368", "type": "external" } ], "gene_names_uniprotkb": "ITIH3", "gene_names_refseq": "ITIH3", "protein_names_uniprotkb": "Inter-alpha-trypsin inhibitor heavy chain H3; ITI heavy chain H3; ITI-HC3; Inter-alpha-inhibitor heavy chain 3", "protein_names_refseq": "ITI heavy chain H3; ITI-HC3; inter-alpha (globulin) inhibitor H3; inter-alpha-inhibitor heavy chain 3; inter-alpha-trypsin inhibitor heavy chain H3 precursor; inter-alpha-trypsin inhibitor heavy chain H3", "tax_id": 9913, "disease": "", "pathway": " (bta:508355); (R-BTA-114608)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16305752;26495903;7504674", "class_list": "", "function": "May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A7MB92;Q0V8M9", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006953 acute-phase response;GO:0030212 hyaluronan metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P56652-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6RAG5-1", "uniprot_id": [ { "id": "F6RAG5_BOVIN", "url": "https://www.uniprot.org/uniprot/F6RAG5", "type": "external" } ], "mass": 110022.0, "length": 964, "protein_name": "Kinesin-like protein", "gene_name": "KIF5C", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "KIF5C", "gene_names_refseq": "", "protein_names_uniprotkb": "Kinesin-like protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005874 microtubule;GO:1904115 axon cytoplasm;GO:0032991 protein-containing complex;GO:0035253 ciliary rootlet;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007292 female gamete generation;GO:0007097 nuclear migration;GO:0048489 synaptic vesicle transport;GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity;GO:0098957 anterograde axonal transport of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6RAG5-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N0U8-1", "uniprot_id": [ { "id": "G3N0U8_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N0U8", "type": "external" } ], "mass": 39067.0, "length": 348, "protein_name": "Erlin", "gene_name": "ERLIN1", "organism": "Bovine", "refseq_name": "erlin-1", "refseq_ac": [ { "id": "NP_001157504", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157504", "type": "external" } ], "gene_names_uniprotkb": "ERLIN1", "gene_names_refseq": "ERLIN1", "protein_names_uniprotkb": "Erlin; Endoplasmic reticulum lipid raft-associated protein; SPFH domain-containing protein; Stomatin-prohibitin-flotillin-HflC/K domain-containing protein", "protein_names_refseq": "SPFH domain family, member 1; erlin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:617074); (R-BTA-382556); (R-BTA-9931269)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0008289 lipid binding;GO:0015485 cholesterol binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0045717 negative regulation of fatty acid biosynthetic process;GO:0045541 negative regulation of cholesterol biosynthetic process;GO:0032933 SREBP signaling pathway;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N0U8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N0R8-1", "uniprot_id": [ { "id": "F1N0R8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N0R8", "type": "external" } ], "mass": 46467.0, "length": 438, "protein_name": "L-serine dehydratase/L-threonine deaminase", "gene_name": "SDS", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SDS", "gene_names_refseq": "", "protein_names_uniprotkb": "L-serine dehydratase/L-threonine deaminase; 4.3.1.17; 4.3.1.19; L-serine deaminase; L-threonine dehydratase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-8849175); (R-BTA-977347)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the pyridoxal-phosphate-dependent dehydrative deamination of L-threonine and L-serine to ammonia and alpha-ketobutyrate and pyruvate, respectively., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.3.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.1.17", "type": "external" }, { "id": "4.3.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.1.18", "type": "external" }, { "id": "5.1.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.1.18", "type": "external" }, { "id": "4.3.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.1.19", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0003941 L-serine ammonia-lyase activity;GO:0004794 threonine deaminase activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006094 gluconeogenesis;GO:0006520 amino acid metabolic process;GO:0042866 pyruvate biosynthetic process;GO:0006567 L-threonine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N0R8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N1U1-1", "uniprot_id": [ { "id": "F1N1U1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N1U1", "type": "external" } ], "mass": 163746.0, "length": 1487, "protein_name": "Synaptojanin-2", "gene_name": "SYNJ2", "organism": "Bovine", "refseq_name": "synaptojanin-2 isoform X1", "refseq_ac": [ { "id": "XP_024852879", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024852879", "type": "external" } ], "gene_names_uniprotkb": "SYNJ2", "gene_names_refseq": "SYNJ2", "protein_names_uniprotkb": "Synaptojanin-2; 3.1.3.36; Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2", "protein_names_refseq": "synaptojanin-2 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1660499); (R-BTA-8856828)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0098793 presynapse;GO:0005737 cytoplasm", "go_biological_process": "GO:0046856 phosphatidylinositol dephosphorylation;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N1U1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N2M2-1", "uniprot_id": [ { "id": "F1N2M2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N2M2", "type": "external" } ], "mass": 182964.0, "length": 1681, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 7", "gene_name": "ADAMTS7", "organism": "Bovine", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform X1", "refseq_ac": [ { "id": "XP_024837785", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837785", "type": "external" } ], "gene_names_uniprotkb": "ADAMTS7", "gene_names_refseq": "ADAMTS7", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 7", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:504694)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Metalloprotease. Was previously shown to degrade COMP. However, a later study found no activity against COMP., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N2M2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N1B8-1", "uniprot_id": [ { "id": "F1N1B8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N1B8", "type": "external" } ], "mass": 147327.0, "length": 1355, "protein_name": "KN motif and ankyrin repeat domains 1", "gene_name": "KANK1", "organism": "Bovine", "refseq_name": "KN motif and ankyrin repeat domain-containing protein 1 isoform X3", "refseq_ac": [ { "id": "XP_002689675", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689675", "type": "external" } ], "gene_names_uniprotkb": "KANK1", "gene_names_refseq": "KANK1", "protein_names_uniprotkb": "KN motif and ankyrin repeat domains 1", "protein_names_refseq": "KN motif and ankyrin repeat domain-containing protein 1 isoform X3", "tax_id": 9913, "disease": "", "pathway": " (bta:534869)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, 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cell migration;GO:0030837 negative regulation of actin filament polymerization;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:1900028 negative regulation of ruffle assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N1B8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6R930-1", "uniprot_id": [ { "id": "F6R930_BOVIN", "url": "https://www.uniprot.org/uniprot/F6R930", "type": "external" } ], "mass": 57596.0, "length": 501, "protein_name": "Phosphodiesterase", "gene_name": "PDE7B", "organism": "Bovine", "refseq_name": "3',5'-cyclic-AMP phosphodiesterase 7B isoform X1", "refseq_ac": [ { "id": "XP_059745687", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745687", "type": "external" } ], "gene_names_uniprotkb": "PDE7B", "gene_names_refseq": "PDE7B", "protein_names_uniprotkb": "Phosphodiesterase; 3.1.4.-", 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"id": "F6REL8_BOVIN", "url": "https://www.uniprot.org/uniprot/F6REL8", "type": "external" } ], "mass": 94962.0, "length": 893, "protein_name": "MICAL like 2", "gene_name": "MICALL2", "organism": "Bovine", "refseq_name": "MICAL-like protein 2 isoform X1", "refseq_ac": [ { "id": "XP_059737220", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059737220", "type": "external" } ], "gene_names_uniprotkb": "MICALL2", "gene_names_refseq": "MICALL2", "protein_names_uniprotkb": "MICAL like 2", "protein_names_refseq": "MICAL-like protein 2 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, 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binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0055037 recycling endosome;GO:0001725 stress fiber;GO:0042995 cell projection", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0032456 endocytic recycling;GO:0031175 neuron projection development;GO:0034446 substrate adhesion-dependent cell spreading;GO:0030041 actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6REL8-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N0S0-1", "uniprot_id": [ { "id": "G3N0S0_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N0S0", "type": "external" } ], "mass": 80822.0, "length": 724, "protein_name": "BRCA1-A complex subunit RAP80", "gene_name": "UIMC1", "organism": "Bovine", "refseq_name": "BRCA1-A complex subunit RAP80 isoform 2", "refseq_ac": [ { "id": "NP_001106693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106693", "type": "external" } ], "gene_names_uniprotkb": "UIMC1", "gene_names_refseq": "RAP80; UIMC1", "protein_names_uniprotkb": "BRCA1-A complex subunit RAP80; Receptor-associated protein 80; Ubiquitin interaction motif-containing protein 1", "protein_names_refseq": "BRCA1-A complex subunit RAP80 isoform 2; receptor associated protein 80", "tax_id": 9913, "disease": "", "pathway": " (bta:508607); (R-BTA-5689901); (R-BTA-5693565); (R-BTA-5693571); (R-BTA-5693607); (R-BTA-69473)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "This gene encodes a member of the RAP80 family of proteins, which are characterized by two tandem ubiquitin-interacting motifs (UIMs). The encoded protein is a subunit of the BRCA1-A complex and functions to recruit this complex to sites of DNA double-strand breaks through its ability to bind poly-ubiquitin chains found at these sites. Homozygous knockout mice for this gene exhibit enhanced sensitivity to ionizing radiation and risk for B-cell lymphoma and impaired DNA double-strand break repair. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding;GO:0061649 ubiquitin-modified histone reader activity;GO:0042393 histone binding", "go_cellular_component": "GO:0070531 BRCA1-A complex;GO:0016604 nuclear body;GO:0035861 site of double-strand break", "go_biological_process": "GO:0006302 double-strand break repair;GO:0045892 negative regulation of DNA-templated transcription;GO:0010212 response to ionizing radiation;GO:0045739 positive regulation of DNA repair;GO:0007095 mitotic G2 DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N0S0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N649-1", "uniprot_id": [ { "id": "F1N649_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N649", "type": "external" } ], "mass": 105893.0, "length": 983, "protein_name": "Seizure related 6 homolog", "gene_name": "SEZ6", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SEZ6", "gene_names_refseq": "", "protein_names_uniprotkb": "Seizure related 6 homolog", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0043197 dendritic spine;GO:0043198 dendritic shaft", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:0021680 cerebellar Purkinje cell layer development;GO:0060074 synapse maturation;GO:0050773 regulation of dendrite development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N649-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N226-1", "uniprot_id": [ { "id": "F1N226_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N226", "type": "external" } ], "mass": 87181.0, "length": 767, "protein_name": "Amyloid beta precursor like protein 2", "gene_name": "APLP2", "organism": "Bovine", "refseq_name": "amyloid beta precursor like protein 2 isoform X1", "refseq_ac": [ { "id": "XP_002699281", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002699281", "type": "external" } ], "gene_names_uniprotkb": "APLP2", "gene_names_refseq": "APLP2", "protein_names_uniprotkb": "Amyloid beta precursor like protein 2; Amyloid beta (A4) precursor-like protein 2; Amyloid protein homolog; Amyloid-like protein 2; CDEI box-binding protein; Sperm membrane protein YWK-II", "protein_names_refseq": "amyloid beta precursor like protein 2 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:785005)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0046914 transition metal ion binding;GO:0046872 metal ion binding;GO:0004867 serine-type endopeptidase inhibitor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0016020 membrane;GO:0012505 endomembrane system;GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N226-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05689-1", "uniprot_id": [ { "id": "CATZ_BOVIN", "url": "https://www.uniprot.org/uniprot/P05689", "type": "external" } ], "mass": 33886.0, "length": 304, "protein_name": "Cathepsin Z", "gene_name": "CTSZ", "organism": "Bovine", "refseq_name": "cathepsin Z precursor", "refseq_ac": [ { "id": "NP_001071303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071303", "type": "external" } ], "gene_names_uniprotkb": "CTSZ", "gene_names_refseq": "CTSZ", "protein_names_uniprotkb": "Cathepsin Z; 3.4.18.1", "protein_names_refseq": "cathepsin Z precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:404187); (R-BTA-2022377); (R-BTA-204005); (R-BTA-432720); (R-BTA-5694530); (R-BTA-6798695)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "3838468", "class_list": "", "function": "Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (By similarity). Capable of producing kinin potentiating peptides (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity. Capable of producing kinin potentiating peptides., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0IIK1", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "3.1.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.1", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0016807 cysteine-type carboxypeptidase activity;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome;GO:0005783 endoplasmic reticulum;GO:0005938 cell cortex;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0051603 proteolysis involved in protein catabolic process;GO:0006508 proteolysis;GO:0010757 negative regulation of plasminogen activation;GO:0060441 epithelial tube branching involved in lung morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P05689-1", "record_type": "protein", 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vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing the stability of this protein in myelin-forming cells of the auditory pathway. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Involved in the regulation of bone metabolism., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0016787 hydrolase activity;GO:0005509 calcium ion binding;GO:0001965 G-protein alpha-subunit binding;GO:0010855 adenylate cyclase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001917 photoreceptor inner segment;GO:0032991 protein-containing complex;GO:0060171 stereocilium membrane;GO:0016020 membrane", "go_biological_process": "GO:0050793 regulation of developmental process;GO:0007166 cell surface receptor signaling pathway;GO:0007605 sensory perception of sound;GO:0048513 animal organ development;GO:0050953 sensory perception of light stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N0A6-1", "record_type": "protein", "filter_code": "0000000.0000000.000100.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6RKH9-1", "uniprot_id": [ { "id": "F6RKH9_BOVIN", "url": "https://www.uniprot.org/uniprot/F6RKH9", "type": "external" } ], "mass": 95466.0, "length": 873, "protein_name": "Integrin beta", "gene_name": "ITGB7", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ITGB7", "gene_names_refseq": "", "protein_names_uniprotkb": "Integrin beta", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Integrin ITGA4/ITGB7 (alpha-4/beta-7) (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin ITGA4/ITGB7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Also interacts with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involve the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Integrin ITGAE/ITGB7 (alpha-E/beta-7, HML-1) is a receptor for E-cadherin., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0034669 integrin alpha4-beta7 complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0050900 leukocyte migration;GO:0034446 substrate adhesion-dependent cell spreading;GO:0050901 leukocyte tethering or rolling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6RKH9-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N348-1", "uniprot_id": [ { "id": "G3N348_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N348", "type": "external" } ], "mass": 99742.0, "length": 888, "protein_name": "Wolframin", "gene_name": "WFS1", "organism": "Bovine", "refseq_name": "wolframin", "refseq_ac": [ { "id": "XP_002688446", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002688446", "type": "external" } ], "gene_names_uniprotkb": "WFS1", "gene_names_refseq": "WFS1", "protein_names_uniprotkb": "Wolframin", "protein_names_refseq": "wolframin", "tax_id": 9913, "disease": "", "pathway": " (bta:100298456); (R-BTA-381426); (R-BTA-8957275)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. Negatively regulates the ER stress response and positively regulates the stability of V-ATPase subunits ATP6V1A and ATP1B1 by preventing their degradation through an unknown proteasome-independent mechanism., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051117 ATPase binding;GO:0031625 ubiquitin protein ligase binding;GO:0140597 protein carrier chaperone", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0030133 transport vesicle;GO:0030141 secretory granule", "go_biological_process": "GO:1902532 negative regulation of intracellular signal transduction;GO:0035556 intracellular signal transduction;GO:0050821 protein stabilization;GO:0031398 positive regulation of protein ubiquitination;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N348-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N7M2-1", "uniprot_id": [ { "id": "F1N7M2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N7M2", "type": "external" } ], "mass": 88284.0, "length": 794, "protein_name": "Cadherin-12", "gene_name": "CDH12", "organism": "Bovine", "refseq_name": "cadherin-12 precursor", "refseq_ac": [ { "id": "NP_001193887", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193887", "type": "external" } ], "gene_names_uniprotkb": "CDH12", "gene_names_refseq": "CDH12", "protein_names_uniprotkb": "Cadherin-12", "protein_names_refseq": "cadherin 12, type 2 (N-cadherin 2); cadherin-12 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:540672); (R-BTA-418990)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins., [UniProtKB, UniProtKB]; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0016342 catenin complex", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N7M2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60661-1", "uniprot_id": [ { "id": "MYL6_BOVIN", "url": "https://www.uniprot.org/uniprot/P60661", "type": "external" } ], "mass": 16930.0, "length": 151, "protein_name": "Myosin light polypeptide 6", "gene_name": "MYL6", "organism": "Bovine", "refseq_name": "myosin light polypeptide 6", "refseq_ac": [ { "id": "NP_786974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786974", "type": "external" } ], "gene_names_uniprotkb": "MYL6", "gene_names_refseq": "MYL6", "protein_names_uniprotkb": "Myosin light polypeptide 6; 17 kDa myosin light chain; LC17; MLC-3; Myosin light chain 3; Myosin light chain A3; Myosin light chain alkali 3", "protein_names_refseq": "17 kDa myosin light chain; LC17; MLC-3; myosin light chain 3; myosin light chain A3; myosin light chain alkali 3; myosin light polypeptide 6; myosin, light chain 6, alkali, smooth muscle and non-muscle; myosin, light peptide 6, alkali, smooth muscle and non-muscle", "tax_id": 9913, "disease": "", "pathway": " (bta:281341); (R-BTA-445355); (R-BTA-5627123)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "2263497", "class_list": "", "function": "Regulatory light chain of myosin. Does not bind calcium., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PJX9;P16475;P24572;P24573;Q12790;Q3SYR6", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008307 structural constituent of muscle;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005903 brush border;GO:0016460 myosin II complex;GO:0016461 unconventional myosin complex;GO:0016459 myosin complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P60661-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62763-1", "uniprot_id": [ { "id": "VISL1_BOVIN", "url": "https://www.uniprot.org/uniprot/P62763", "type": "external" } ], "mass": 22142.0, "length": 191, "protein_name": "Visinin-like protein 1", "gene_name": "VSNL1", "organism": "Bovine", "refseq_name": "visinin-like protein 1", "refseq_ac": [ { "id": "NP_776915", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776915", "type": "external" } ], "gene_names_uniprotkb": "VSNL1", "gene_names_refseq": "VSNL1", "protein_names_uniprotkb": "Visinin-like protein 1; Neurocalcin-alpha", "protein_names_refseq": "neurocalcin alpha; visinin-like protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:282124)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1527077;9560316", "class_list": "", "function": "Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P28677;P29103;P42323;Q3ZBI8;Q9UM20", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P62763-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O46415-1", "uniprot_id": [ { "id": "FRIL_BOVIN", "url": "https://www.uniprot.org/uniprot/O46415", "type": "external" } ], "mass": 19988.0, "length": 175, "protein_name": "Ferritin light chain", "gene_name": "FTL; LOC788801", "organism": "Bovine", "refseq_name": "ferritin light chain", "refseq_ac": [ { "id": "NP_777217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777217", "type": "external" } ], "gene_names_uniprotkb": "FTL; LOC788801", "gene_names_refseq": "FTL", "protein_names_uniprotkb": "Ferritin light chain; Ferritin L subunit", "protein_names_refseq": "ferritin L subunit; ferritin light chain; ferritin, light polypeptide", "tax_id": 9913, "disease": "", "pathway": " (bta:286861); (bta:788801); (R-BTA-6798695); (R-BTA-917937)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "9467878", "class_list": "", "function": "Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). Delivery to lysosomes by the cargo receptor NCOA4 for autophagic degradation and release or iron (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZBZ3;Q53YP3", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0008198 ferrous iron binding;GO:0008199 ferric iron binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031410 cytoplasmic vesicle;GO:0005776 autophagosome;GO:0044754 autolysosome;GO:0070288 ferritin complex", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0006826 iron ion transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O46415-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MYW3-1", "uniprot_id": [ { "id": "F1MYW3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MYW3", "type": "external" } ], "mass": 89493.0, "length": 775, "protein_name": "Semaphorin 3E", "gene_name": "SEMA3E", "organism": "Bovine", "refseq_name": "semaphorin-3E", "refseq_ac": [ { "id": "XP_003586003", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586003", "type": "external" } ], "gene_names_uniprotkb": "SEMA3E", "gene_names_refseq": "SEMA3E", "protein_names_uniprotkb": "Semaphorin 3E", "protein_names_refseq": "semaphorin-3E", "tax_id": 9913, "disease": "", "pathway": " (bta:535644); (R-BTA-416700)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0050808 synapse organization;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0071526 semaphorin-plexin signaling pathway;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MYW3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F2Z4E9-1", "uniprot_id": [ { "id": "F2Z4E9_BOVIN", "url": "https://www.uniprot.org/uniprot/F2Z4E9", "type": "external" } ], "mass": 73903.0, "length": 689, "protein_name": "Cleavage and polyadenylation specificity factor subunit 6", "gene_name": "CPSF6", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CPSF6", "gene_names_refseq": "", "protein_names_uniprotkb": "Cleavage and polyadenylation specificity factor subunit 6", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-73856); (R-BTA-77595); (R-BTA-9770562)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery. Plays a role in mRNA export., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0043023 ribosomal large subunit binding;GO:1990448 exon-exon junction complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005726 perichromatin fibrils;GO:1990904 ribonucleoprotein complex;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0046833 positive regulation of RNA export from nucleus;GO:0051290 protein heterotetramerization;GO:0110104 mRNA alternative polyadenylation;GO:0180010 co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F2Z4E9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56701-1", "uniprot_id": [ { "id": "PSMD2_BOVIN", "url": "https://www.uniprot.org/uniprot/P56701", "type": "external" } ], "mass": 100258.0, "length": 908, "protein_name": "26S proteasome non-ATPase regulatory subunit 2", "gene_name": "PSMD2", "organism": "Bovine", "refseq_name": "26S proteasome non-ATPase regulatory subunit 2", "refseq_ac": [ { "id": "NP_001094667", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094667", "type": "external" } ], "gene_names_uniprotkb": "PSMD2; TRAP2", "gene_names_refseq": "PSMD2", "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 2; 26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; Tumor necrosis factor type 1 receptor-associated protein 2", "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 2; 26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; proteasome 26S non-ATPase subunit 2; proteasome 26S subunit, non-ATPase 2; tumor necrosis factor type 1 receptor-associated protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:539784); (R-BTA-1169091); (R-BTA-1234176); (R-BTA-1236978); (R-BTA-174084); (R-BTA-174154); (R-BTA-174178); (R-BTA-174184); (R-BTA-187577); (R-BTA-195253); (R-BTA-202424); (R-BTA-2467813); (R-BTA-2871837); (R-BTA-349425); (R-BTA-350562); (R-BTA-382556); (R-BTA-450408); (R-BTA-4608870); (R-BTA-4641257); (R-BTA-4641258); (R-BTA-5358346); (R-BTA-5607761); (R-BTA-5607764); (R-BTA-5610780); (R-BTA-5610785); (R-BTA-5632684); (R-BTA-5668541); (R-BTA-5676590); (R-BTA-5687128); (R-BTA-5689603); (R-BTA-5689880); (R-BTA-6798695); (R-BTA-68867); (R-BTA-68949); (R-BTA-69017); (R-BTA-69481); (R-BTA-69601); (R-BTA-75815); (R-BTA-8852276); (R-BTA-8854050); (R-BTA-8939236); (R-BTA-8939902); (R-BTA-8941858); (R-BTA-8948751); (R-BTA-8951664); (R-BTA-9020702); (R-BTA-9755511); (R-BTA-9762114); (R-BTA-9766229); (R-BTA-983168); (R-BTA-9907900); (R-BTA-9929356); (R-BTA-9929491); (R-BTA-9931269); (R-BTA-9932298); (R-BTA-9954709)", "pathway_count": 56, "publication_count": 3, "publication_id_list": "16305752;8063704;8774743", "class_list": "", "function": "Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7E3R5;Q2HJE3;Q9TRA7", "ec_number_list": [], "go_molecular_function": "GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0034515 proteasome storage granule;GO:0008540 proteasome regulatory particle, base subcomplex;GO:0022624 proteasome accessory complex;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0042176 regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P56701-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N0H3-1", "uniprot_id": [ { "id": "F1N0H3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N0H3", "type": "external" } ], "mass": 29086.0, "length": 260, "protein_name": "Carbonic anhydrase", "gene_name": "CA2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CA2", "gene_names_refseq": "", "protein_names_uniprotkb": "Carbonic anhydrase; 4.2.1.1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1237044); (R-BTA-1247673); (R-BTA-1475029)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Reversible hydration of carbon dioxide., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "4.2.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.69", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity;GO:0018820 cyanamide hydratase activity;GO:0004064 arylesterase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0045177 apical part of cell", "go_biological_process": "GO:0038166 angiotensin-activated signaling pathway;GO:0015670 carbon dioxide transport;GO:0051453 regulation of intracellular pH;GO:0044070 regulation of monoatomic anion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N0H3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N3S4-1", "uniprot_id": [ { "id": "F1N3S4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N3S4", "type": "external" } ], "mass": 95098.0, "length": 838, "protein_name": "Cullin 4A", "gene_name": "CUL4A", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CUL4A", "gene_names_refseq": "", "protein_names_uniprotkb": "Cullin 4A", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-110314); (R-BTA-5696394); (R-BTA-5696395); (R-BTA-5696400); (R-BTA-6781823); (R-BTA-6782135); (R-BTA-6782210); (R-BTA-8951664)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0061630 ubiquitin protein ligase activity;GO:0160072 ubiquitin ligase complex scaffold activity", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0042254 ribosome biogenesis;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0001701 in utero embryonic development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N3S4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50397-1", "uniprot_id": [ { "id": "GDIB_BOVIN", "url": "https://www.uniprot.org/uniprot/P50397", "type": "external" } ], "mass": 50488.0, "length": 445, "protein_name": "Rab GDP dissociation inhibitor beta", "gene_name": "GDI2", "organism": "Bovine", "refseq_name": "rab GDP dissociation inhibitor beta", "refseq_ac": [ { "id": "NP_001028934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028934", "type": "external" } ], "gene_names_uniprotkb": "GDI2; RABGDIB", "gene_names_refseq": "GDI2", "protein_names_uniprotkb": "Rab GDP dissociation inhibitor beta; GDI-2; Guanosine diphosphate dissociation inhibitor 2; Rab GDI beta", "protein_names_refseq": "GDI-2; guanosine diphosphate (GDP) dissociation inhibitor 2; guanosine diphosphate dissociation inhibitor 2; rab GDI beta; rab GDP dissociation inhibitor beta", "tax_id": 9913, "disease": "", "pathway": " (bta:509832); (R-BTA-6798695); (R-BTA-8876198)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "16305752;7513052", "class_list": "", "function": "GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking. Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D985;Q3MHL1", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005093 Rab GDP-dissociation inhibitor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0015031 protein transport;GO:0007264 small GTPase-mediated signal transduction;GO:0016192 vesicle-mediated transport;GO:1903565 negative regulation of protein localization to cilium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P50397-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X755-1", "uniprot_id": [ { "id": "G3X755_BOVIN", "url": "https://www.uniprot.org/uniprot/G3X755", "type": "external" } ], "mass": 214896.0, "length": 1938, "protein_name": "Plexin-B2", "gene_name": "PLXNB2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PLXNB2", "gene_names_refseq": "", "protein_names_uniprotkb": "Plexin-B2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017154 semaphorin receptor activity", "go_cellular_component": "GO:0002116 semaphorin receptor complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0007162 negative regulation of cell adhesion;GO:0071526 semaphorin-plexin signaling pathway;GO:0007416 synapse assembly;GO:0030334 regulation of cell migration;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3X755-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N4U6-1", "uniprot_id": [ { "id": "F1N4U6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N4U6", "type": "external" } ], "mass": 44899.0, "length": 387, "protein_name": "gamma-butyrobetaine dioxygenase", "gene_name": "BBOX1", "organism": "Bovine", "refseq_name": "gamma-butyrobetaine dioxygenase", "refseq_ac": [ { "id": "NP_001095351", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095351", "type": "external" } ], "gene_names_uniprotkb": "BBOX1", "gene_names_refseq": "BBOX1", "protein_names_uniprotkb": "gamma-butyrobetaine dioxygenase; 1.14.11.1; Gamma-butyrobetaine hydroxylase; Gamma-butyrobetaine,2-oxoglutarate dioxygenase", "protein_names_refseq": "butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1; gamma-butyrobetaine dioxygenase", "tax_id": 9913, "disease": "", "pathway": " (bta:507159); (R-BTA-71262)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the formation of L-carnitine from gamma-butyrobetaine., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.1", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0008336 gamma-butyrobetaine dioxygenase activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0045329 carnitine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N4U6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52173-1", "uniprot_id": [ { "id": "IL5_BOVIN", "url": "https://www.uniprot.org/uniprot/P52173", "type": "external" } ], "mass": 15229.0, "length": 134, "protein_name": "Interleukin-5", "gene_name": "IL5", "organism": "Bovine", "refseq_name": "interleukin-5 precursor", "refseq_ac": [ { "id": "NP_776347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776347", "type": "external" } ], "gene_names_uniprotkb": "IL5", "gene_names_refseq": "IL-5; IL5; TRF", "protein_names_uniprotkb": "Interleukin-5; Eosinophil differentiation factor; IL-5; T-cell replacing factor; TRF", "protein_names_refseq": "T-cell replacing factor; colony-stimulating factor, eosinophil; eosinophil differentiation factor; interleukin-5 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:280825); (R-BTA-512988); (R-BTA-5673001); (R-BTA-912526)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "8918267", "class_list": "", "function": "Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A9QWQ8", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0005137 interleukin-5 receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0038043 interleukin-5-mediated signaling pathway;GO:0006955 immune response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0071803 positive regulation of podosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P52173-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E690-1", "uniprot_id": [ { "id": "G5E690_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E690", "type": "external" } ], "mass": 79594.0, "length": 742, "protein_name": "Golgi associated, gamma adaptin ear containing, ARF binding protein 3", "gene_name": "GGA3", "organism": "Bovine", "refseq_name": "ADP-ribosylation factor-binding protein GGA3 isoform 2", "refseq_ac": [ { "id": "NP_001421939", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421939", "type": "external" } ], "gene_names_uniprotkb": "GGA3", "gene_names_refseq": "GGA3", "protein_names_uniprotkb": "Golgi associated, gamma adaptin ear containing, ARF binding protein 3", "protein_names_refseq": "ADP-ribosylation factor-binding protein GGA3 isoform 2; ADP-ribosylation factor-binding protein GGA3", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-8875656)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0035091 phosphatidylinositol binding;GO:0043130 ubiquitin binding;GO:0044877 protein-containing complex binding;GO:0140318 protein transporter activity", "go_cellular_component": "GO:0031901 early endosome membrane;GO:0005802 trans-Golgi network;GO:0005764 lysosome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0034394 protein localization to cell surface;GO:0006893 Golgi to plasma membrane transport;GO:1902430 negative regulation of amyloid-beta formation;GO:0043001 Golgi to plasma membrane protein transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E690-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MZ07-1", "uniprot_id": [ { "id": "G3MZ07_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MZ07", "type": "external" } ], "mass": 211142.0, "length": 1872, "protein_name": "Voltage-dependent L-type calcium channel subunit alpha", "gene_name": "CACNA1S", "organism": "Bovine", "refseq_name": "voltage-dependent L-type calcium channel subunit alpha-1S isoform X1", "refseq_ac": [ { "id": "XP_024832342", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832342", "type": "external" } ], "gene_names_uniprotkb": "CACNA1S", "gene_names_refseq": "CACNA1S", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit alpha", "protein_names_refseq": "voltage-dependent L-type calcium channel subunit alpha-1S isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:100337204)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005245 voltage-gated calcium channel activity;GO:0008331 high voltage-gated calcium channel activity", "go_cellular_component": "GO:0030315 T-tubule;GO:0005891 voltage-gated calcium channel complex;GO:0031674 I band;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0006936 muscle contraction;GO:0051209 release of sequestered calcium ion into cytosol", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3MZ07-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17453-1", "uniprot_id": [ { "id": "BPI_BOVIN", "url": "https://www.uniprot.org/uniprot/P17453", "type": "external" } ], "mass": 53442.0, "length": 482, "protein_name": "Bactericidal permeability-increasing protein", "gene_name": "BPI", "organism": "Bovine", "refseq_name": "bactericidal permeability-increasing protein precursor", "refseq_ac": [ { "id": "NP_776320", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776320", "type": "external" } ], "gene_names_uniprotkb": "BPI", "gene_names_refseq": "BPI", "protein_names_uniprotkb": "Bactericidal permeability-increasing protein; BPI", "protein_names_refseq": "bactericidal permeability-increasing protein precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:280734); (R-BTA-166016); (R-BTA-6798695); (R-BTA-6803157)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "18492132;2349103", "class_list": "", "function": "Polymorphism in BPI has no effect on daughter yield deviation for somatic cell score in Holstein cattle., [RefSeq, PubMed]; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, 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"GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0032715 negative regulation of interleukin-6 production;GO:0032720 negative regulation of tumor necrosis factor production;GO:0043031 negative regulation of macrophage activation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P17453-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N144-1", "uniprot_id": [ { "id": "F1N144_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N144", "type": "external" } ], "mass": 65136.0, "length": 579, "protein_name": "Adenosine deaminase 2", "gene_name": "ADA2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ADA2", "gene_names_refseq": "", "protein_names_uniprotkb": "Adenosine deaminase 2; 3.5.4.4; Cat eye syndrome critical region protein 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5683826); (R-BTA-6798695)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.4.2.28", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.28", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0004000 adenosine deaminase activity;GO:0046872 metal ion binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0031685 adenosine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006154 adenosine catabolic process;GO:0046103 inosine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N144-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6PR67-1", "uniprot_id": [ { "id": "F6PR67_BOVIN", "url": "https://www.uniprot.org/uniprot/F6PR67", "type": "external" } ], "mass": 40010.0, "length": 355, "protein_name": "Mitochondrial import inner membrane translocase subunit TIM50", "gene_name": "TIMM50", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TIMM50", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit TIM50", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0005134 interleukin-2 receptor binding;GO:0004725 protein tyrosine phosphatase activity;GO:0140608 cysteine-type endopeptidase activator activity", "go_cellular_component": "GO:0005744 TIM23 mitochondrial import inner membrane translocase complex;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016607 nuclear speck", "go_biological_process": "GO:0015031 protein transport;GO:0030150 protein import into mitochondrial matrix;GO:0007006 mitochondrial membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6PR67-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77512-1", "uniprot_id": [ { "id": "GLYAL_BOVIN", "url": "https://www.uniprot.org/uniprot/O77512", "type": "external" } ], "mass": 33684.0, "length": 295, "protein_name": "Glycine N-phenylacetyltransferase", "gene_name": "GAT", "organism": "Bovine", "refseq_name": "glycine N-phenylacetyltransferase", "refseq_ac": [ { "id": "NP_803452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803452", "type": "external" } ], "gene_names_uniprotkb": "GAT", "gene_names_refseq": "GAT", "protein_names_uniprotkb": "Glycine N-phenylacetyltransferase; 2.3.1.192; ArAlk; Arylacetyl-CoA N-acyltransferase; Arylacetyl-CoA:amino acid N-acyltransferase; Arylacetyltransferase", "protein_names_refseq": "arAlk; aralkyl-CoA N-acyltransferase; arylacetyl-CoA N-acyltransferase; arylacetyl-CoA:amino acid N-acyltransferase; arylacetyltransferase; glycine N-phenylacetyltransferase; putative glycine-N-acyltransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:280801)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1445276;9664233", "class_list": "", "function": "Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Can conjugate a multitude of substrates to form a variety of N-acylglycines. Catalyzes the conjugation of arylacetic acids with glycine but does not have activity towards any alkyl-CoA., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O62832;Q9T2T9", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.192", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.192", "type": "external" } ], "go_molecular_function": "GO:0016410 N-acyltransferase activity;GO:0047961 glycine N-acyltransferase activity;GO:0102080 phenylacetyl-coenzyme A:glycine N-acyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O77512-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N0T6-1", "uniprot_id": [ { "id": "F1N0T6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N0T6", "type": "external" } ], "mass": 56880.0, "length": 506, "protein_name": "histidine--tRNA ligase", "gene_name": "HARS2", "organism": "Bovine", "refseq_name": "histidine--tRNA ligase, mitochondrial isoform X1", "refseq_ac": [ { "id": "XP_010805666", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010805666", "type": "external" } ], "gene_names_uniprotkb": "HARS2", "gene_names_refseq": "HARS2", "protein_names_uniprotkb": "histidine--tRNA ligase; 6.1.1.21; Histidyl-tRNA synthetase", "protein_names_refseq": "histidine--tRNA ligase, mitochondrial isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.21", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004821 histidine-tRNA ligase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006412 translation;GO:0006427 histidyl-tRNA aminoacylation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N0T6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10881-1", "uniprot_id": [ { "id": "LA_BOVIN", "url": "https://www.uniprot.org/uniprot/P10881", "type": "external" } ], "mass": 46534.0, "length": 404, "protein_name": "Lupus La protein homolog", "gene_name": "SSB", "organism": "Bovine", "refseq_name": "lupus La protein homolog", "refseq_ac": [ { "id": "NP_788838", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788838", "type": "external" } ], "gene_names_uniprotkb": "SSB", "gene_names_refseq": "SSB", "protein_names_uniprotkb": "Lupus La protein homolog; La autoantigen homolog; La ribonucleoprotein", "protein_names_refseq": "Sjogren syndrome antigen B (autoantigen La); la autoantigen homolog; la ribonucleoprotein; lupus La protein homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:338071)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2468131", "class_list": "", "function": "Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZBL2", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:1990825 sequence-specific mRNA binding;GO:0000049 tRNA binding;GO:0008266 poly(U) RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule;GO:1990904 ribonucleoprotein complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0008033 tRNA processing;GO:0045727 positive regulation of translation;GO:1903608 protein localization to cytoplasmic stress granule;GO:0075522 IRES-dependent viral translational initiation;GO:0006409 tRNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P10881-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19141-1", "uniprot_id": [ { "id": "CRBB3_BOVIN", "url": "https://www.uniprot.org/uniprot/P19141", "type": "external" } ], "mass": 24328.0, "length": 211, "protein_name": "Beta-crystallin B3", "gene_name": "CRYBB3", "organism": "Bovine", "refseq_name": "beta-crystallin B3", "refseq_ac": [ { "id": "NP_776952", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776952", "type": "external" } ], "gene_names_uniprotkb": "CRYBB3", "gene_names_refseq": "CRYBB3", "protein_names_uniprotkb": "Beta-crystallin B3; Beta-B3 crystallin", "protein_names_refseq": "beta-B3 crystallin; beta-crystallin B3", "tax_id": 9913, "disease": "", "pathway": " (bta:282206)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12803541;19206113;6698025", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Detection & sructure of the betaB2-B3-crystallin heterodimer; results suggest the betaB2 subunit adopts a more compacted form than in its monomeric form in order for much of its structure to be enveloped by the betaB3 subunit within the heterodimer, [RefSeq, PubMed]; The sequencing of glycated bovine lens proteins reveals in this study that the protein initially glycated by glucose is gamma IIIb-crystallin, identified by the peptide sequences Gly-Asp-Tyr-Pro-Asp-Tyr-Gln-Gln and Tyr-Glu-Leu-Pro-Asn-Tyr-Arg., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O18790", "ec_number_list": [], "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P19141-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6R1G6-1", "uniprot_id": [ { "id": "F6R1G6_BOVIN", "url": "https://www.uniprot.org/uniprot/F6R1G6", "type": "external" } ], "mass": 55419.0, "length": 494, "protein_name": "tRNA:m(4)X modification enzyme TRM13", "gene_name": "TRMT13", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TRMT13", "gene_names_refseq": "", "protein_names_uniprotkb": "tRNA:m(4)X modification enzyme TRM13; 2.1.1.225", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.225", "type": "external" } ], "go_molecular_function": "GO:0106050 tRNA 2'-O-methyltransferase activity;GO:0008270 zinc ion binding;GO:0008175 tRNA methyltransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0030488 tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6R1G6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6R1R5-1", "uniprot_id": [ { "id": "F6R1R5_BOVIN", "url": "https://www.uniprot.org/uniprot/F6R1R5", "type": "external" } ], "mass": 36665.0, "length": 340, "protein_name": "GMP reductase", "gene_name": "GMPR", "organism": "Bovine", "refseq_name": "GMP reductase 1 isoform X1", "refseq_ac": [ { "id": "XP_010816786", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010816786", "type": "external" } ], "gene_names_uniprotkb": "GMPR", "gene_names_refseq": "GMPR", "protein_names_uniprotkb": "GMP reductase; 1.7.1.7; GMPR; Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase", "protein_names_refseq": "GMP reductase 1 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-74217)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.7.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.7", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003920 GMP reductase activity", "go_cellular_component": "GO:1902560 GMP reductase complex", "go_biological_process": "GO:0006144 purine nucleobase metabolic process;GO:0006163 purine nucleotide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6R1R5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N3P2-1", "uniprot_id": [ { "id": "F1N3P2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N3P2", "type": "external" } ], "mass": 95815.0, "length": 858, "protein_name": "Ubiquitin carboxyl-terminal hydrolase", "gene_name": "USP5", "organism": "Bovine", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 5", "refseq_ac": [ { "id": "NP_001178985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178985", "type": "external" } ], "gene_names_uniprotkb": "USP5", "gene_names_refseq": "USP5", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase; 3.4.19.12", "protein_names_refseq": "Ubiquitin isopeptidase T; ubiquitin carboxyl-terminal hydrolase 5", "tax_id": 9913, "disease": "", "pathway": " (bta:505280); (R-BTA-5689880); (R-BTA-8866652)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0010494 cytoplasmic stress granule;GO:0005829 cytosol;GO:0098793 presynapse", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N3P2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N5H2-1", "uniprot_id": [ { "id": "F1N5H2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N5H2", "type": "external" } ], "mass": 53374.0, "length": 465, "protein_name": "Alpha-L-fucosidase", "gene_name": "FUCA2", "organism": "Bovine", "refseq_name": "plasma alpha-L-fucosidase precursor", "refseq_ac": [ { "id": "NP_001192747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192747", "type": "external" } ], "gene_names_uniprotkb": "FUCA2", "gene_names_refseq": "FUCA2", "protein_names_uniprotkb": "Alpha-L-fucosidase; 3.2.1.51", "protein_names_refseq": "fucosidase, alpha-L- 2, plasma; plasma alpha-L-fucosidase precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:515729); (R-BTA-381426); (R-BTA-6798695); (R-BTA-8957275)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.69", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" } ], "go_molecular_function": "GO:0004560 alpha-L-fucosidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome", "go_biological_process": "GO:0006004 fucose metabolic process;GO:2000535 regulation of entry of bacterium into host cell;GO:0009617 response to bacterium;GO:0016139 glycoside catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N5H2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MYL8-1", "uniprot_id": [ { "id": "F1MYL8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MYL8", "type": "external" } ], "mass": 239433.0, "length": 2174, "protein_name": "Mediator of RNA polymerase II transcription subunit 13", "gene_name": "MED13", "organism": "Bovine", "refseq_name": "mediator of RNA polymerase II transcription subunit 13 isoform X1", "refseq_ac": [ { "id": "XP_024836374", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836374", "type": "external" } ], "gene_names_uniprotkb": "MED13", "gene_names_refseq": "MED13", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 13", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 13 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:524868); (R-BTA-212436); (R-BTA-9841922)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity;GO:0003713 transcription coactivator activity;GO:0046966 nuclear thyroid hormone receptor binding", "go_cellular_component": "GO:0016592 mediator complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MYL8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24591-1", "uniprot_id": [ { "id": "IBP1_BOVIN", "url": "https://www.uniprot.org/uniprot/P24591", "type": "external" } ], "mass": 28794.0, "length": 263, "protein_name": "Insulin-like growth factor-binding protein 1", "gene_name": "IGFBP1", "organism": "Bovine", "refseq_name": "insulin-like growth factor-binding protein 1 precursor", "refseq_ac": [ { "id": "NP_776979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776979", "type": "external" } ], "gene_names_uniprotkb": "IGFBP1", "gene_names_refseq": "IGFBP1", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 1; IBP-1; IGF-binding protein 1; IGFBP-1; bIGFBP-1", "protein_names_refseq": "IBP-1; IGF-binding protein 1; IGFBP-1; bIGFBP-1; insulin-like growth factor-binding protein 1 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:282259); (R-BTA-381426); (R-BTA-8957275)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "14561651;1722724;19497977", "class_list": "", "function": "Allantoic fluid levels of IGFBP-1 were increased in nuclear transfer pregnancies, [RefSeq, PubMed]; IGFBP1 is a common endometrial marker of conceptus elongation in sheep and cattle and most likely regulates conceptus elongation by stimulating migration and attachment of the trophectoderm, [RefSeq, PubMed]; Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner. Also plays a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif. Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway (By similarity). Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A degradation through ubiquitination (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2T9Z3", "ec_number_list": [], "go_molecular_function": "GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding;GO:0005520 insulin-like growth factor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0043567 regulation of insulin-like growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P24591-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10949-1", "uniprot_id": [ { "id": "RAB3C_BOVIN", "url": "https://www.uniprot.org/uniprot/P10949", "type": "external" } ], "mass": 25938.0, "length": 227, "protein_name": "Ras-related protein Rab-3C", "gene_name": "RAB3C", "organism": "Bovine", "refseq_name": "ras-related protein Rab-3C", "refseq_ac": [ { "id": "NP_001040071", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040071", "type": "external" } ], "gene_names_uniprotkb": "RAB3C", "gene_names_refseq": "RAB3C", "protein_names_uniprotkb": "Ras-related protein Rab-3C; 3.6.5.2; SMG P25C", "protein_names_refseq": "GTP-binding protein (smg p25C); SMG P25C; ras-related protein Rab-3C", "tax_id": 9913, "disease": "", "pathway": " (bta:338100); (R-BTA-8873719)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "3136152;35871249", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, 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"https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0031489 myosin V binding;GO:0003925 G protein activity;GO:0030742 GTP-dependent protein binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0008021 synaptic vesicle;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0015031 protein transport;GO:0006887 exocytosis;GO:0006886 intracellular protein transport;GO:0019882 antigen processing and presentation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P10949-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6RN30-1", "uniprot_id": [ { "id": "F6RN30_BOVIN", "url": "https://www.uniprot.org/uniprot/F6RN30", "type": "external" } ], "mass": 73442.0, "length": 668, "protein_name": "Golgi associated, gamma adaptin ear containing, ARF binding protein 1", "gene_name": "GGA1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GGA1", "gene_names_refseq": "", "protein_names_uniprotkb": "Golgi associated, gamma adaptin ear containing, ARF binding protein 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0035091 phosphatidylinositol binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0031901 early endosome membrane;GO:0005802 trans-Golgi network;GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:1990778 protein localization to cell periphery;GO:0006886 intracellular protein transport;GO:0072657 protein localization to membrane;GO:0006893 Golgi to plasma membrane transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6RN30-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N0H2-1", "uniprot_id": [ { "id": "F1N0H2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N0H2", "type": "external" } ], "mass": 29017.0, "length": 246, "protein_name": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase", "gene_name": "HACD4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HACD4", "gene_names_refseq": "", "protein_names_uniprotkb": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; 4.2.1.134", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-75876)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.134", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.134", "type": "external" } ], "go_molecular_function": "GO:0102158 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity;GO:0019899 enzyme binding;GO:0018812 3-hydroxyacyl-CoA dehydratase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0030497 fatty acid elongation;GO:0042761 very long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N0H2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26444-1", "uniprot_id": [ { "id": "CRBA2_BOVIN", "url": "https://www.uniprot.org/uniprot/P26444", "type": "external" } ], "mass": 22231.0, "length": 197, "protein_name": "Beta-crystallin A2", "gene_name": "CRYBA2", "organism": "Bovine", "refseq_name": "beta-crystallin A2", "refseq_ac": [ { "id": "NP_776949", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776949", "type": "external" } ], "gene_names_uniprotkb": "CRYBA2", "gene_names_refseq": "CRYBA2", "protein_names_uniprotkb": "Beta-crystallin A2; Beta-A2 crystallin", "protein_names_refseq": "beta-A2 crystallin; beta-crystallin A2", "tax_id": 9913, "disease": "", "pathway": " (bta:282203)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1874445;6698025", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005212 structural constituent of eye lens;GO:0042802 identical protein binding", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P26444-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N277-1", "uniprot_id": [ { "id": "G3N277_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N277", "type": "external" } ], "mass": 84079.0, "length": 744, "protein_name": "Kinesin-like protein", "gene_name": "KIF2A", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "KIF2A", "gene_names_refseq": "", "protein_names_uniprotkb": "Kinesin-like protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule;GO:0000922 spindle pole;GO:0005654 nucleoplasm", "go_biological_process": "GO:0051301 cell division;GO:0007018 microtubule-based movement;GO:0007019 microtubule depolymerization;GO:0090307 mitotic spindle assembly;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N277-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E531-1", "uniprot_id": [ { "id": "G5E531_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E531", "type": "external" } ], "mass": 60222.0, "length": 556, "protein_name": "T-complex protein 1 subunit alpha", "gene_name": "TCP1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TCP1", "gene_names_refseq": "", "protein_names_uniprotkb": "T-complex protein 1 subunit alpha; CCT-alpha", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-390471); (R-BTA-5620922); (R-BTA-6814122)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "39743588", "class_list": "", "function": "Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0140662 ATP-dependent protein folding chaperone;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005832 chaperonin-containing T-complex;GO:0005794 Golgi apparatus;GO:0005874 microtubule;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0050821 protein stabilization;GO:0006457 protein folding;GO:1904874 positive regulation of telomerase RNA localization to Cajal body", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "G5E531-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E5D4-1", "uniprot_id": [ { "id": "G5E5D4_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E5D4", "type": "external" } ], "mass": 89008.0, "length": 796, "protein_name": "Serine/threonine-protein kinase MARK1", "gene_name": "MARK1", "organism": "Bovine", "refseq_name": "serine/threonine-protein kinase MARK1 isoform X1", "refseq_ac": [ { "id": "XP_024832143", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832143", "type": "external" } ], "gene_names_uniprotkb": "MARK1", "gene_names_refseq": "MARK1", "protein_names_uniprotkb": "Serine/threonine-protein kinase MARK1; 2.7.11.1; 2.7.11.26; MAP/microtubule affinity-regulating kinase 1", "protein_names_refseq": "serine/threonine-protein kinase MARK1 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": 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"url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0008289 lipid binding;GO:0050321 tau-protein kinase activity;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0030425 dendrite;GO:0042995 cell projection;GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0035556 intracellular signal transduction;GO:0050773 regulation of dendrite development;GO:0010719 negative regulation of epithelial to mesenchymal transition;GO:0051654 establishment of mitochondrion localization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E5D4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X6R3-1", "uniprot_id": [ { "id": "G3X6R3_BOVIN", "url": "https://www.uniprot.org/uniprot/G3X6R3", "type": "external" } ], "mass": 145735.0, "length": 1268, "protein_name": "Cohesin subunit SA", "gene_name": "STAG2", "organism": "Bovine", "refseq_name": "cohesin subunit SA-2 isoform 1", "refseq_ac": [ { "id": "NP_001341589", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341589", "type": "external" } ], "gene_names_uniprotkb": "STAG2", "gene_names_refseq": "STAG2", "protein_names_uniprotkb": "Cohesin subunit SA; SCC3 homolog; Stromal antigen", "protein_names_refseq": "cohesin subunit SA-2 isoform 1", "tax_id": 9913, "disease": "", "pathway": " (bta:616487); (R-BTA-2467813); (R-BTA-2468052); (R-BTA-2470946); (R-BTA-2500257); (R-BTA-3108214)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. 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"0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MXQ8-1", "uniprot_id": [ { "id": "G3MXQ8_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MXQ8", "type": "external" } ], "mass": 74109.0, "length": 655, "protein_name": "alpha-1,2-Mannosidase", "gene_name": "MAN1B1", "organism": "Bovine", "refseq_name": "endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X2", "refseq_ac": [ { "id": "XP_024855499", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855499", "type": "external" } ], "gene_names_uniprotkb": "MAN1B1", "gene_names_refseq": "MAN1B1", "protein_names_uniprotkb": "alpha-1,2-Mannosidase; 3.2.1.-", "protein_names_refseq": "endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:107131137)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in 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It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, 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"0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N1H2-1", "uniprot_id": [ { "id": "F1N1H2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N1H2", "type": "external" } ], "mass": 112484.0, "length": 1066, "protein_name": "Microtubule associated protein 1S", "gene_name": "MAP1S", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MAP1S", "gene_names_refseq": "", "protein_names_uniprotkb": "Microtubule associated protein 1S", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, 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"total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0098794 postsynapse", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007266 Rho protein signal transduction;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008217 regulation of blood pressure;GO:0150052 regulation of postsynapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E6P3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61284-1", "uniprot_id": [ { "id": "RL12_BOVIN", "url": "https://www.uniprot.org/uniprot/P61284", "type": "external" } ], "mass": 17819.0, "length": 165, "protein_name": "Large ribosomal subunit protein uL11", "gene_name": "RPL12", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein uL11", "refseq_ac": [ { "id": "NP_991366", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991366", "type": "external" } ], "gene_names_uniprotkb": "RPL12", "gene_names_refseq": "RPL12", "protein_names_uniprotkb": "Large ribosomal subunit protein uL11; 60S ribosomal protein L12", "protein_names_refseq": "60S ribosomal protein L12; large ribosomal subunit protein uL11", "tax_id": 9913, "disease": "", "pathway": " (bta:404133); (R-BTA-156827); (R-BTA-1799339); (R-BTA-6791226); (R-BTA-72689); (R-BTA-72706); (R-BTA-975956); (R-BTA-975957); (R-BTA-9954709); (R-BTA-9954714); (R-BTA-9954716)", "pathway_count": 11, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds directly to 26S ribosomal RNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PJB1;Q3SZV1", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070180 large ribosomal subunit rRNA binding", "go_cellular_component": "GO:0014069 postsynaptic density;GO:0022625 cytosolic large ribosomal subunit;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P61284-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11834-1", "uniprot_id": [ { "id": "OPCM_BOVIN", "url": "https://www.uniprot.org/uniprot/P11834", "type": "external" } ], "mass": 37914.0, "length": 345, "protein_name": "Opioid-binding protein/cell adhesion molecule", "gene_name": "OPCML", "organism": "Bovine", "refseq_name": "opioid-binding protein/cell adhesion molecule precursor", "refseq_ac": [ { "id": "NP_776832", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776832", "type": "external" } ], "gene_names_uniprotkb": "OPCML; OBCAM; OCAM", "gene_names_refseq": "OBCAM; OPCML", "protein_names_uniprotkb": "Opioid-binding protein/cell adhesion molecule; OBCAM; OPCML; Opioid-binding cell adhesion molecule", "protein_names_refseq": "opioid-binding cell adhesion molecule; opioid-binding protein/cell adhesion molecule precursor; opioid-binding protein/cell adhesion molecule", "tax_id": 9913, "disease": "", "pathway": " (bta:281957); (R-BTA-163125)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "2721489", "class_list": "", "function": "Binds opioids in the presence of acidic lipids; probably involved in cell contact., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0098552 side of membrane", "go_biological_process": "GO:0051963 regulation of synapse assembly;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P11834-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6Q4V7-1", "uniprot_id": [ { "id": "F6Q4V7_BOVIN", "url": "https://www.uniprot.org/uniprot/F6Q4V7", "type": "external" } ], "mass": 53814.0, "length": 465, "protein_name": "Gamma-aminobutyric acid type A receptor subunit gamma1", "gene_name": "GABRG1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GABRG1", "gene_names_refseq": "", "protein_names_uniprotkb": "Gamma-aminobutyric acid type A receptor subunit gamma1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005254 chloride channel activity;GO:0004890 GABA-A receptor activity;GO:0005230 extracellular ligand-gated monoatomic ion channel activity;GO:0022851 GABA-gated chloride ion channel activity", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0034707 chloride channel complex;GO:0098794 postsynapse;GO:0032590 dendrite membrane;GO:1902711 GABA-A receptor complex", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6Q4V7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N1K4-1", "uniprot_id": [ { "id": "G3N1K4_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N1K4", "type": "external" } ], "mass": 243109.0, "length": 2178, "protein_name": "Mediator complex subunit 12", "gene_name": "MED12", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MED12", "gene_names_refseq": "", "protein_names_uniprotkb": "Mediator complex subunit 12", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-212436); (R-BTA-9841922)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008013 beta-catenin binding;GO:0003712 transcription coregulator activity;GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0016592 mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N1K4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X795-1", "uniprot_id": [ { "id": "G3X795_BOVIN", "url": "https://www.uniprot.org/uniprot/G3X795", "type": "external" } ], "mass": 80745.0, "length": 704, "protein_name": "Neurolysin, mitochondrial", "gene_name": "NLN", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NLN", "gene_names_refseq": "", "protein_names_uniprotkb": "Neurolysin, mitochondrial; 3.4.24.16; Microsomal endopeptidase; Mitochondrial oligopeptidase M; Neurotensin endopeptidase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-375276)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.24.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.16", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding;GO:0042277 peptide binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3X795-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MZN7-1", "uniprot_id": [ { "id": "F1MZN7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MZN7", "type": "external" } ], "mass": 58435.0, "length": 519, "protein_name": "Sorting nexin-2", "gene_name": "SNX2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SNX2", "gene_names_refseq": "", "protein_names_uniprotkb": "Sorting nexin-2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-432722)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Required for retrograde endosome-to-TGN transport of TGN38. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035091 phosphatidylinositol binding;GO:0005158 insulin receptor binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0005154 epidermal growth factor receptor binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030027 lamellipodium;GO:0031901 early endosome membrane;GO:0030904 retromer complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0072673 lamellipodium morphogenesis;GO:0034498 early endosome to Golgi transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MZN7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N4Y2-1", "uniprot_id": [ { "id": "F1N4Y2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N4Y2", "type": "external" } ], "mass": 55821.0, "length": 488, "protein_name": "5-hydroxytryptamine receptor 3A", "gene_name": "HTR3A", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HTR3A", "gene_names_refseq": "", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 3A; 5-hydroxytryptamine receptor 3; Serotonin receptor 3A; Serotonin-gated ion channel receptor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-112314)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A8J8XUH6;V6F7Y8", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005230 extracellular ligand-gated monoatomic ion channel activity;GO:0022850 serotonin-gated monoatomic cation channel activity;GO:0042802 identical protein binding;GO:0051378 serotonin binding", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0043005 neuron projection;GO:0032154 cleavage furrow", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0007268 chemical synaptic transmission;GO:0034220 monoatomic ion transmembrane transport;GO:0140227 serotonin-gated cation-selective signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N4Y2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6Q4B1-1", "uniprot_id": [ { "id": "F6Q4B1_BOVIN", "url": "https://www.uniprot.org/uniprot/F6Q4B1", "type": "external" } ], "mass": 92011.0, "length": 823, "protein_name": "Neuroligin 1", "gene_name": "NLGN1", "organism": "Bovine", "refseq_name": "neuroligin-1", "refseq_ac": [ { "id": "NP_001192902", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192902", "type": "external" } ], "gene_names_uniprotkb": "NLGN1", "gene_names_refseq": "NLGN1", "protein_names_uniprotkb": "Neuroligin 1", "protein_names_refseq": "neuroligin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:530042); (R-BTA-6794361)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042043 neurexin family protein binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0098793 presynapse;GO:0005886 plasma membrane", "go_biological_process": "GO:0072553 terminal button organization;GO:0016080 synaptic vesicle targeting;GO:0048789 cytoskeletal matrix organization at active zone;GO:0097091 synaptic vesicle clustering;GO:0097115 neurexin clustering involved in presynaptic membrane assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6Q4B1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6RIX5-1", "uniprot_id": [ { "id": "F6RIX5_BOVIN", "url": "https://www.uniprot.org/uniprot/F6RIX5", "type": "external" } ], "mass": 85332.0, "length": 782, "protein_name": "Activin receptor type-1", "gene_name": "ACVR1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ACVR1", "gene_names_refseq": "", "protein_names_uniprotkb": "Activin receptor type-1; 2.7.11.30; Activin receptor type I; Serine/threonine-protein kinase receptor R1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004675 transmembrane receptor protein serine/threonine kinase activity;GO:0005025 transforming growth factor beta receptor activity, type I;GO:0046332 SMAD binding", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0070724 BMP receptor complex", "go_biological_process": "GO:0048731 system development;GO:0050793 regulation of developmental process;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0032924 activin receptor signaling pathway;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6RIX5-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MZC5-1", "uniprot_id": [ { "id": "F1MZC5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MZC5", "type": "external" } ], "mass": 37590.0, "length": 337, "protein_name": "Phosphatidate cytidylyltransferase, mitochondrial", "gene_name": "TAMM41", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TAMM41", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphatidate cytidylyltransferase, mitochondrial; 2.7.7.41; CDP-diacylglycerol synthase; Mitochondrial translocator assembly and maintenance protein 41 homolog", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.41", "type": "external" } ], "go_molecular_function": "GO:0004605 phosphatidate cytidylyltransferase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005739 mitochondrion", "go_biological_process": "GO:0016024 CDP-diacylglycerol biosynthetic process;GO:0032049 cardiolipin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MZC5-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62248-1", "uniprot_id": [ { "id": "MYDGF_BOVIN", "url": "https://www.uniprot.org/uniprot/P62248", "type": "external" } ], "mass": 19030.0, "length": 174, "protein_name": "Myeloid-derived growth factor", "gene_name": "MYDGF", "organism": "Bovine", "refseq_name": "myeloid-derived growth factor precursor", "refseq_ac": [ { "id": "NP_001001164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001164", "type": "external" } ], "gene_names_uniprotkb": "MYDGF", "gene_names_refseq": "C19orf10; C7H19orf10; MYDGF", "protein_names_uniprotkb": "Myeloid-derived growth factor; MYDGF", "protein_names_refseq": "UPF0556 protein C19orf10 homolog; myeloid-derived growth factor precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:407769)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30573663", "class_list": "", "function": "Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T039", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0001525 angiogenesis;GO:0001934 positive regulation of protein phosphorylation;GO:0043066 negative regulation of apoptotic process;GO:0043410 positive regulation of MAPK cascade;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P62248-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N646-1", "uniprot_id": [ { "id": "F1N646_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N646", "type": "external" } ], "mass": 42441.0, "length": 385, "protein_name": "Cell adhesion molecule 4", "gene_name": "CADM4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CADM4", "gene_names_refseq": "", "protein_names_uniprotkb": "Cell adhesion molecule 4; Immunoglobulin superfamily member 4C; Nectin-like protein 4", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043183 vascular endothelial growth factor receptor 1 binding;GO:0030971 receptor tyrosine kinase binding;GO:0019903 protein phosphatase binding;GO:0043184 vascular endothelial growth factor receptor 2 binding", "go_cellular_component": "GO:0016020 membrane;GO:0031252 cell leading edge;GO:0044291 cell-cell contact zone", "go_biological_process": "GO:0007155 cell adhesion;GO:0061041 regulation of wound healing;GO:0042127 regulation of cell population proliferation;GO:2000145 regulation of cell motility;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N646-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6RUZ4-1", "uniprot_id": [ { "id": "F6RUZ4_BOVIN", "url": "https://www.uniprot.org/uniprot/F6RUZ4", "type": "external" } ], "mass": 120736.0, "length": 1099, "protein_name": "Contactin-5", "gene_name": "CNTN5", "organism": "Bovine", "refseq_name": "contactin-5 precursor", "refseq_ac": [ { "id": "NP_001095681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095681", "type": "external" } ], "gene_names_uniprotkb": "CNTN5", "gene_names_refseq": "CNTN5", "protein_names_uniprotkb": "Contactin-5", "protein_names_refseq": "contactin-5 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:538198); (R-BTA-163125)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, 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"AA1R_BOVIN", "url": "https://www.uniprot.org/uniprot/P28190", "type": "external" } ], "mass": 36593.0, "length": 326, "protein_name": "Adenosine receptor A1", "gene_name": "ADORA1", "organism": "Bovine", "refseq_name": "adenosine receptor A1", "refseq_ac": [ { "id": "NP_776922", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776922", "type": "external" } ], "gene_names_uniprotkb": "ADORA1", "gene_names_refseq": "ADORA1", "protein_names_uniprotkb": "Adenosine receptor A1", "protein_names_refseq": "adenosine receptor A1", "tax_id": 9913, "disease": "", "pathway": " (bta:282133); (R-BTA-417973); (R-BTA-418594)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "1551415;1587851;16305752;23523559;23613714", "class_list": "", "function": "Adenosine A1 receptors promote vasa vasorum endothelial cell barrier integrity via Gi and Akt-dependent actin cytoskeleton remodeling. Erratum:[PLoS One. 2013;8(5). doi10.1371/annotation/42ab28e5-36fe-4a5f-b6aa-5cfec1bf2e63. Siddaramappa Umapathy, Nagavedi [corrected to Umapathy, Siddaramappa Nagavedi]] Publication Status: Online-Only, [RefSeq, PubMed]; Data suggest that that ADORA1 forms homomers/homodimers in brain cortex., [RefSeq, PubMed]; Receptor for adenosine. The activity of this receptor is mediated by G proteins such as GNAI2 which inhibit adenylyl cyclase (By similarity)., [UniProtKB, UniProtKB]; Receptor for adenosine. 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"external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0007346 regulation of mitotic cell cycle;GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N2F6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10950-1", "uniprot_id": [ { "id": "ASMT_BOVIN", "url": "https://www.uniprot.org/uniprot/P10950", "type": "external" } ], "mass": 37924.0, "length": 345, "protein_name": "Acetylserotonin O-methyltransferase", "gene_name": "ASMT", "organism": "Bovine", "refseq_name": "acetylserotonin O-methyltransferase", "refseq_ac": [ { "id": "NP_803459", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803459", "type": "external" } ], "gene_names_uniprotkb": "ASMT", "gene_names_refseq": "ASMT; HIOMT", "protein_names_uniprotkb": "Acetylserotonin O-methyltransferase; 2.1.1.4; HIOMT; Hydroxyindole O-methyltransferase", "protein_names_refseq": "acetylserotonin O-methyltransferase; hydroxyindole O-methyltransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:281013); (R-BTA-209931)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1544900;21381146;3818627;8574683", "class_list": "", "function": "Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The study revealed that ASMT and MTNR1A genes were expressed in cumulus-oocyte complexes (COCs)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q28123", "ec_number_list": [ { "id": "2.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.4", "type": "external" } ], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0017096 acetylserotonin O-methyltransferase activity;GO:0008171 O-methyltransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0032259 methylation;GO:0030187 melatonin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P10950-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N6L1-1", "uniprot_id": [ { "id": "F1N6L1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N6L1", "type": "external" } ], "mass": 127478.0, "length": 1145, "protein_name": "Valine--tRNA ligase, mitochondrial", "gene_name": "VARS2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "VARS2", "gene_names_refseq": "", "protein_names_uniprotkb": "Valine--tRNA ligase, mitochondrial; 6.1.1.9; Valyl-tRNA synthetase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the attachment of valine to tRNA(Val) in a two-step reaction: valine is first activated by ATP to form Val-AMP and then transferred to the acceptor end of tRNA(Val)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.9", "type": "external" } ], "go_molecular_function": "GO:0002161 aminoacyl-tRNA deacylase activity;GO:0004832 valine-tRNA ligase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006438 valyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N6L1-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33672-1", "uniprot_id": [ { "id": "PSB3_BOVIN", "url": "https://www.uniprot.org/uniprot/P33672", "type": "external" } ], "mass": 22993.0, "length": 205, "protein_name": "Proteasome subunit beta type-3", "gene_name": "PSMB3", "organism": "Bovine", "refseq_name": "proteasome subunit beta type-3", "refseq_ac": [ { "id": "NP_001029768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029768", "type": "external" } ], "gene_names_uniprotkb": "PSMB3", "gene_names_refseq": "PSMB3", "protein_names_uniprotkb": "Proteasome subunit beta type-3; Proteasome chain 13; Proteasome component C10-II; Proteasome theta chain", "protein_names_refseq": "proteasome (prosome, macropain) subunit, beta type, 3; proteasome chain 13; proteasome component C10-II; proteasome subunit beta 3; proteasome subunit beta type-3; proteasome theta chain", "tax_id": 9913, "disease": "", "pathway": " (bta:533874); (R-BTA-1169091); (R-BTA-1234176); (R-BTA-1236974); (R-BTA-1236978); (R-BTA-174084); (R-BTA-174154); (R-BTA-174178); (R-BTA-174184); (R-BTA-187577); (R-BTA-195253); (R-BTA-202424); (R-BTA-2467813); (R-BTA-2871837); (R-BTA-349425); (R-BTA-350562); (R-BTA-382556); (R-BTA-450408); (R-BTA-4608870); (R-BTA-4641257); (R-BTA-4641258); (R-BTA-5358346); (R-BTA-5607761); (R-BTA-5607764); (R-BTA-5610780); (R-BTA-5610785); (R-BTA-5632684); (R-BTA-5668541); (R-BTA-5676590); (R-BTA-5687128); (R-BTA-5689603); (R-BTA-5689880); (R-BTA-68867); (R-BTA-68949); (R-BTA-69017); (R-BTA-69481); (R-BTA-69601); (R-BTA-75815); (R-BTA-8852276); (R-BTA-8854050); (R-BTA-8939236); (R-BTA-8939902); (R-BTA-8941858); (R-BTA-8948751); (R-BTA-8951664); (R-BTA-9020702); (R-BTA-9755511); (R-BTA-9762114); (R-BTA-9766229); (R-BTA-983168); (R-BTA-9907900); (R-BTA-9912633); (R-BTA-9929356); (R-BTA-9929491); (R-BTA-9931269); (R-BTA-9932298); (R-BTA-9954709)", "pathway_count": 57, "publication_count": 2, "publication_id_list": "12015144;1510924", "class_list": "", "function": "Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity., [UniProtKB, UniProtKB, UniProtKB]; Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T059", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0019774 proteasome core complex, beta-subunit complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005839 proteasome core complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006979 response to oxidative stress;GO:0061136 regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P33672-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X793-1", "uniprot_id": [ { "id": "G3X793_BOVIN", "url": "https://www.uniprot.org/uniprot/G3X793", "type": "external" } ], "mass": 41428.0, "length": 364, "protein_name": "mitogen-activated protein kinase", "gene_name": "MAPK11", "organism": "Bovine", "refseq_name": "mitogen-activated protein kinase 11 isoform X3", "refseq_ac": [ { "id": "XP_024848020", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848020", "type": "external" } ], "gene_names_uniprotkb": "MAPK11", "gene_names_refseq": "MAPK11", "protein_names_uniprotkb": "mitogen-activated protein kinase; 2.7.11.24", "protein_names_refseq": "mitogen-activated protein kinase 11 isoform X3", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-168638); (R-BTA-171007); (R-BTA-198753); (R-BTA-2559580); (R-BTA-4420097); (R-BTA-450302); (R-BTA-450341); (R-BTA-525793); (R-BTA-5668599); (R-BTA-6804756); (R-BTA-69601)", "pathway_count": 11, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004707 MAP kinase activity;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0071493 cellular response to UV-B;GO:0035556 intracellular signal transduction;GO:0060348 bone development;GO:0001649 osteoblast differentiation;GO:0051403 stress-activated MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3X793-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N1W1-1", "uniprot_id": [ { "id": "F1N1W1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N1W1", "type": "external" } ], "mass": 235918.0, "length": 2121, "protein_name": "Oxygen-regulated protein 1", "gene_name": "RP1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Oxygen-regulated protein 1; Retinitis pigmentosa RP1 protein homolog", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photoreceptor cells, it plays a role in the organization of the outer segment of rod and cone photoreceptors ensuring the correct orientation and higher-order stacking of outer segment disks along the photoreceptor axoneme., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0001917 photoreceptor inner segment;GO:0005930 axoneme;GO:0032391 photoreceptor connecting cilium;GO:0001750 photoreceptor outer segment;GO:0005875 microtubule associated complex", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007601 visual perception;GO:0030030 cell projection organization;GO:0009416 response to light stimulus;GO:0045494 photoreceptor cell maintenance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N1W1-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N340-1", "uniprot_id": [ { "id": "G3N340_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N340", "type": "external" } ], "mass": 53602.0, "length": 475, "protein_name": "tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like", "gene_name": "DUS1L", "organism": "Bovine", "refseq_name": "tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like", "refseq_ac": [ { "id": "NP_001421996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421996", "type": "external" } ], "gene_names_uniprotkb": "DUS1L", "gene_names_refseq": "DUS1L", "protein_names_uniprotkb": "tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like; 1.3.1.88; tRNA-dihydrouridine synthase 1-like", "protein_names_refseq": "PP3111 protein; tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U16 and U17 in cytoplasmic tRNAs. Affects the level of some mature tRNA and thereby the total cellular translation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.1.88", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.88", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0050660 flavin adenine dinucleotide binding;GO:0017150 tRNA dihydrouridine synthase activity;GO:0102262 tRNA-dihydrouridine16 synthase activity;GO:0102263 tRNA-dihydrouridine17 synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0008033 tRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N340-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6RA94-1", "uniprot_id": [ { "id": "F6RA94_BOVIN", "url": "https://www.uniprot.org/uniprot/F6RA94", "type": "external" } ], "mass": 79734.0, "length": 735, "protein_name": "Diacylglycerol lipase-beta", "gene_name": "DAGLB", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DAGLB", "gene_names_refseq": "", "protein_names_uniprotkb": "Diacylglycerol lipase-beta; 3.1.1.116; PUFA-specific triacylglycerol lipase; Sn1-specific diacylglycerol lipase beta", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-426048)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production. Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids. Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Also functions as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0047372 monoacylglycerol lipase activity;GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0019369 arachidonate metabolic process;GO:0010898 positive regulation of triglyceride catabolic process;GO:0050727 regulation of inflammatory response;GO:0046340 diacylglycerol catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6RA94-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MYW1-1", "uniprot_id": [ { "id": "F1MYW1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MYW1", "type": "external" } ], "mass": 277076.0, "length": 2550, "protein_name": "Stabilin-2", "gene_name": "STAB2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "STAB2", "gene_names_refseq": "", "protein_names_uniprotkb": "Stabilin-2; Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2142845); (R-BTA-2160916); (R-BTA-3000497)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005540 hyaluronic acid binding;GO:0038024 cargo receptor activity;GO:0005044 scavenger receptor activity;GO:0005041 low-density lipoprotein particle receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005829 cytosol", "go_biological_process": "GO:0007155 cell adhesion;GO:0006898 receptor-mediated endocytosis;GO:0050830 defense response to Gram-positive bacterium;GO:0030214 hyaluronan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MYW1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E581-1", "uniprot_id": [ { "id": "G5E581_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E581", "type": "external" } ], "mass": 45275.0, "length": 419, "protein_name": "G-protein coupled receptor 143", "gene_name": "GPR143", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GPR143", "gene_names_refseq": "", "protein_names_uniprotkb": "G-protein coupled receptor 143", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:613505); (R-BTA-375280); (R-BTA-416476)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0035240 dopamine binding;GO:0072544 L-DOPA binding;GO:0072545 L-tyrosine binding;GO:0035643 L-DOPA receptor activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0016324 apical plasma membrane;GO:0033162 melanosome membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0032438 melanosome organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E581-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MYB4-1", "uniprot_id": [ { "id": "G3MYB4_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MYB4", "type": "external" } ], "mass": 157169.0, "length": 1419, "protein_name": "Formin 1", "gene_name": "FMN1", "organism": "Bovine", "refseq_name": "formin-1 isoform X1", "refseq_ac": [ { "id": "XP_059746781", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059746781", "type": "external" } ], "gene_names_uniprotkb": "FMN1", "gene_names_refseq": "FMN1", "protein_names_uniprotkb": "Formin 1", "protein_names_refseq": "formin-1 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:786165)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0045010 actin nucleation;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3MYB4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N0E5-1", "uniprot_id": [ { "id": "F1N0E5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N0E5", "type": "external" } ], "mass": 58162.0, "length": 542, "protein_name": "T-complex protein 1 subunit delta", "gene_name": "CCT4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CCT4", "gene_names_refseq": "", "protein_names_uniprotkb": "T-complex protein 1 subunit delta", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-390471); (R-BTA-5620922); (R-BTA-6814122)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "39743588", 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"biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0140662 ATP-dependent protein folding chaperone", "go_cellular_component": "GO:0005832 chaperonin-containing T-complex;GO:0005813 centrosome;GO:0005874 microtubule;GO:0044297 cell body;GO:0002199 zona pellucida receptor complex", "go_biological_process": "GO:0050821 protein stabilization;GO:0006457 protein folding;GO:1904874 positive regulation of telomerase RNA localization to Cajal body", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1N0E5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N026-1", "uniprot_id": [ { "id": "F1N026_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N026", "type": "external" } ], "mass": 30386.0, "length": 266, "protein_name": "Integral membrane protein 2", "gene_name": "ITM2B", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ITM2B", "gene_names_refseq": "", "protein_names_uniprotkb": "Integral membrane protein 2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers., [UniProtKB, UniProtKB]; Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42., [UniProtKB, UniProtKB]; Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005794 Golgi apparatus;GO:0010008 endosome membrane", "go_biological_process": "GO:0042985 negative regulation of amyloid precursor protein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N026-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X783-1", "uniprot_id": [ { "id": "G3X783_BOVIN", "url": "https://www.uniprot.org/uniprot/G3X783", "type": "external" } ], "mass": 87701.0, "length": 821, "protein_name": "Mitogen-activated protein kinase 8 interacting protein 2", "gene_name": "MAPK8IP2", "organism": "Bovine", "refseq_name": "C-Jun-amino-terminal kinase-interacting protein 2", "refseq_ac": [ { "id": "NP_001180128", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180128", "type": "external" } ], "gene_names_uniprotkb": "MAPK8IP2", "gene_names_refseq": "MAPK8IP2", "protein_names_uniprotkb": "Mitogen-activated protein kinase 8 interacting protein 2", "protein_names_refseq": "C-Jun-amino-terminal kinase-interacting protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:618893)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019894 kinesin binding;GO:0005078 MAP-kinase scaffold activity;GO:0008432 JUN kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0043025 neuronal cell body", "go_biological_process": "GO:0046328 regulation of JNK cascade;GO:0046958 nonassociative learning;GO:0007617 mating behavior;GO:0098815 modulation of excitatory postsynaptic potential;GO:0007254 JNK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3X783-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MY67-1", "uniprot_id": [ { "id": "G3MY67_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MY67", "type": "external" } ], "mass": 73064.0, "length": 665, "protein_name": "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "gene_name": "SDHA", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SDHA", "gene_names_refseq": "", "protein_names_uniprotkb": "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; 1.3.5.1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:281480); (R-BTA-71403); (R-BTA-9854311)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate. Can act as a tumor suppressor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.5.1", "type": "external" }, { "id": "1.1.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.5.-", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0008177 succinate dehydrogenase (quinone) activity;GO:0009055 electron transfer activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0045273 respiratory chain complex II (succinate dehydrogenase)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0022900 electron transport chain;GO:0007399 nervous system development;GO:0006105 succinate metabolic process;GO:0006121 mitochondrial electron transport, succinate to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3MY67-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MZA9-1", "uniprot_id": [ { "id": "F1MZA9_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MZA9", "type": "external" } ], "mass": 47822.0, "length": 440, "protein_name": "POU domain protein", "gene_name": "POU2F3", "organism": "Bovine", "refseq_name": "POU domain, class 2, transcription factor 3", "refseq_ac": [ { "id": "NP_001192759", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192759", "type": "external" } ], "gene_names_uniprotkb": "POU2F3", "gene_names_refseq": "POU2F3", "protein_names_uniprotkb": "POU domain protein", "protein_names_refseq": "POU domain, class 2, transcription factor 3", "tax_id": 9913, "disease": "", "pathway": " (bta:516493)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030216 keratinocyte differentiation;GO:0043922 host-mediated suppression of viral transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MZA9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MZU6-1", "uniprot_id": [ { "id": "F1MZU6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MZU6", "type": "external" } ], "mass": 160630.0, "length": 1670, "protein_name": "Collagen type IV alpha 3 chain", "gene_name": "COL4A3", "organism": "Bovine", "refseq_name": "collagen alpha-3(IV) chain precursor", "refseq_ac": [ { "id": "NP_001160001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160001", "type": "external" } ], "gene_names_uniprotkb": "COL4A3", "gene_names_refseq": "COL4A3", "protein_names_uniprotkb": "Collagen type IV alpha 3 chain", "protein_names_refseq": "collagen alpha-3(IV) chain precursor; collagen alpha-3(IV) chain; collagen, type IV, alpha 3 (Goodpasture antigen)", "tax_id": 9913, "disease": "", "pathway": " (bta:317711)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005201 extracellular matrix structural constituent;GO:0005178 integrin binding;GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0005604 basement membrane;GO:0005581 collagen trimer;GO:0031012 extracellular matrix;GO:0005587 collagen type IV trimer", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0030198 extracellular matrix organization;GO:0016525 negative regulation of angiogenesis;GO:0032836 glomerular basement membrane development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MZU6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MY31-1", "uniprot_id": [ { "id": "G3MY31_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MY31", "type": "external" } ], "mass": 33218.0, "length": 283, "protein_name": "Inhibitor of growth protein", "gene_name": "ING2", "organism": "Bovine", "refseq_name": "inhibitor of growth protein 2", "refseq_ac": [ { "id": "NP_001180154", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180154", "type": "external" } ], "gene_names_uniprotkb": "ING2", "gene_names_refseq": "ING2; INGX", "protein_names_uniprotkb": "Inhibitor of growth protein", "protein_names_refseq": "inhibitor of growth family, X-linked, pseudogene; inhibitor of growth protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:404141); (R-BTA-3899300); (R-BTA-6811555)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of an histone acetyltransferase complex., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0044877 protein-containing complex binding;GO:0035091 phosphatidylinositol binding;GO:0140002 histone H3K4me3 reader activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0070822 Sin3-type complex;GO:0016602 CCAAT-binding factor complex;GO:0005634 nucleus", "go_biological_process": "GO:0048133 male germ-line stem cell asymmetric division;GO:0030317 flagellated sperm motility;GO:0007286 spermatid development;GO:0045893 positive regulation of DNA-templated transcription;GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3MY31-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N272-1", "uniprot_id": [ { "id": "F1N272_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N272", "type": "external" } ], "mass": 133844.0, "length": 1197, "protein_name": "Cation-transporting ATPase", "gene_name": "ATP13A4", "organism": "Bovine", "refseq_name": "probable cation-transporting ATPase 13A4 isoform X1", "refseq_ac": [ { "id": "XP_002684905", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002684905", "type": "external" } ], "gene_names_uniprotkb": "ATP13A4", "gene_names_refseq": "ATP13A4", "protein_names_uniprotkb": "Cation-transporting ATPase; 7.2.2.-", "protein_names_refseq": "probable cation-transporting ATPase 13A4 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:521728); (R-BTA-936837)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, 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"glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", 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"https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity;GO:0015662 P-type ion transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:1902047 polyamine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N272-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G1K1H0-1", "uniprot_id": [ { "id": "G1K1H0_BOVIN", "url": "https://www.uniprot.org/uniprot/G1K1H0", "type": "external" } ], "mass": 83127.0, "length": 745, "protein_name": "Disintegrin and metalloproteinase domain-containing protein 2", "gene_name": "ADAM2", "organism": "Bovine", "refseq_name": "disintegrin and metalloproteinase domain-containing protein 2 isoform X2", "refseq_ac": [ { "id": "XP_024841957", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841957", "type": "external" } ], "gene_names_uniprotkb": "ADAM2", "gene_names_refseq": "ADAM2", "protein_names_uniprotkb": "Disintegrin and metalloproteinase domain-containing protein 2; Fertilin subunit beta; PH-30; PH30-beta", "protein_names_refseq": "disintegrin and metalloproteinase domain-containing protein 2 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2534343)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0007155 cell adhesion;GO:0007339 binding of sperm to zona pellucida;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G1K1H0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N015-1", "uniprot_id": [ { "id": "F1N015_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N015", "type": "external" } ], "mass": 51631.0, "length": 464, "protein_name": "Aldehyde dehydrogenase", "gene_name": "ALDH3A1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ALDH3A1", "gene_names_refseq": "", "protein_names_uniprotkb": "Aldehyde dehydrogenase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-211945)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins. 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In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0051019 mitogen-activated protein kinase binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N1U0-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61955-1", "uniprot_id": [ { "id": "SUMO2_BOVIN", "url": "https://www.uniprot.org/uniprot/P61955", "type": "external" } ], "mass": 10871.0, "length": 95, "protein_name": "Small ubiquitin-related modifier 2", "gene_name": "SUMO2", "organism": "Bovine", "refseq_name": "small ubiquitin-related modifier 2 isoform X1", "refseq_ac": [ { "id": "XP_059734616", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059734616", "type": "external" } ], "gene_names_uniprotkb": "SUMO2; SMT3B", "gene_names_refseq": "SUMO2", "protein_names_uniprotkb": "Small ubiquitin-related modifier 2; SUMO-2; Smt3B; Ubiquitin-like protein SMT3B", "protein_names_refseq": "small ubiquitin-related modifier 2 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:132342073); (bta:286807); (R-BTA-196791); (R-BTA-3065679); (R-BTA-3108214); (R-BTA-3232118); (R-BTA-3899300); (R-BTA-4085377); (R-BTA-4090294); (R-BTA-4551638); (R-BTA-4570464); (R-BTA-4615885); (R-BTA-5693607); (R-BTA-5696395)", "pathway_count": 14, "publication_count": 2, "publication_id_list": "16305752;9833880", "class_list": "", "function": "Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. Plays a role in the regulation of sumoylation status of SETX (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P55855;Q3ZCG1;Q5E979", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0044389 ubiquitin-like protein ligase binding;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016605 PML body", "go_biological_process": "GO:0016925 protein sumoylation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P61955-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E577-1", "uniprot_id": [ { "id": "G5E577_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E577", "type": "external" } ], "mass": 82698.0, "length": 722, "protein_name": "Mitogen-activated protein kinase 6", "gene_name": "MAPK6", "organism": "Bovine", "refseq_name": "mitogen-activated protein kinase 6 isoform X1", "refseq_ac": [ { "id": "XP_002691011", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691011", "type": "external" } ], "gene_names_uniprotkb": "MAPK6", "gene_names_refseq": "MAPK6", "protein_names_uniprotkb": "Mitogen-activated protein kinase 6; 2.7.11.24", "protein_names_refseq": "mitogen-activated protein kinase 6 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:538094); (R-BTA-5687128)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004707 MAP kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0019901 protein kinase binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032156 septin cytoskeleton;GO:0032991 protein-containing complex", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E577-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E683-1", "uniprot_id": [ { "id": "G5E683_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E683", "type": "external" } ], "mass": 43162.0, "length": 417, "protein_name": "Methyl-CpG binding domain protein 2", "gene_name": "MBD2", "organism": "Bovine", "refseq_name": "methyl-CpG-binding domain protein 2 isoform X1", "refseq_ac": [ { "id": "XP_024840333", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024840333", "type": "external" } ], "gene_names_uniprotkb": "MBD2", "gene_names_refseq": "MBD2", "protein_names_uniprotkb": "Methyl-CpG binding domain protein 2", "protein_names_refseq": "methyl-CpG-binding domain protein 2 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:100337206); (R-BTA-427413); (R-BTA-73728); (R-BTA-9937850); (R-BTA-9940951)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003729 mRNA binding;GO:0008327 methyl-CpG binding;GO:0035197 siRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000792 heterochromatin;GO:0016581 NuRD complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006346 DNA methylation-dependent constitutive heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E683-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N3B3-1", "uniprot_id": [ { "id": "G3N3B3_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N3B3", "type": "external" } ], "mass": 44975.0, "length": 422, "protein_name": "Probable protein phosphatase 1N", "gene_name": "PPM1N", "organism": "Bovine", "refseq_name": "probable protein phosphatase 1N isoform 2", "refseq_ac": [ { "id": "NP_001421726", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421726", "type": "external" } ], "gene_names_uniprotkb": "PPM1N", "gene_names_refseq": "PPM1N", "protein_names_uniprotkb": "Probable protein phosphatase 1N; 3.1.3.16", "protein_names_refseq": "probable protein phosphatase 1N isoform 2", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0043122 regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N3B3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6Q9S4-1", "uniprot_id": [ { "id": "F6Q9S4_BOVIN", "url": "https://www.uniprot.org/uniprot/F6Q9S4", "type": "external" } ], "mass": 46332.0, "length": 418, "protein_name": "Protein kinase cAMP-dependent type II regulatory subunit beta", "gene_name": "PRKAR2B", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PRKAR2B", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein kinase cAMP-dependent type II regulatory subunit beta", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-163615); (R-BTA-164378); (R-BTA-180024); (R-BTA-2565942); (R-BTA-380259); (R-BTA-380270); (R-BTA-380284); (R-BTA-380320); (R-BTA-432040); (R-BTA-442720); (R-BTA-5610787); (R-BTA-5620912); (R-BTA-8854518); (R-BTA-9634597); (R-BTA-983231); (R-BTA-9856530)", "pathway_count": 16, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008603 cAMP-dependent protein kinase regulator activity;GO:0030552 cAMP binding;GO:0034236 protein kinase A catalytic subunit binding;GO:0004862 cAMP-dependent protein kinase inhibitor activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005952 cAMP-dependent protein kinase complex;GO:0098978 glutamatergic synapse;GO:0005813 centrosome", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0050804 modulation of chemical synaptic transmission;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6Q9S4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34943-1", "uniprot_id": [ { "id": "NDUA9_BOVIN", "url": "https://www.uniprot.org/uniprot/P34943", "type": "external" } ], "mass": 42849.0, "length": 380, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial", "gene_name": "NDUFA9", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial precursor", "refseq_ac": [ { "id": "NP_991386", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_991386", "type": "external" } ], "gene_names_uniprotkb": "NDUFA9", "gene_names_refseq": "NDUFA9", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial; CI-39kD; Complex I-39kD; NADH-ubiquinone oxidoreductase 39 kDa subunit", "protein_names_refseq": "CI-39kD; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa; NADH dehydrogenase (ubiquinone) 42 kDa subunit; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial precursor; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial; NADH-ubiquinone oxidoreductase 39 kDa subunit; complex I-39kD", "tax_id": 9913, "disease": "", "pathway": " (bta:404188); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10852722;1832859;18721790;23454639", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB]; Data indicate that in the D-form of complex I the ND3 subunit crosslinked to the 39 kDa (NDUFA9) subunit., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0K3", "ec_number_list": [], "go_molecular_function": "GO:0003954 NADH dehydrogenase activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0007623 circadian rhythm;GO:0006744 ubiquinone biosynthetic process;GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P34943-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N431-1", "uniprot_id": [ { "id": "F1N431_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N431", "type": "external" } ], "mass": 48740.0, "length": 425, "protein_name": "Farnesyl pyrophosphate synthase", "gene_name": "FDPS", "organism": "Bovine", "refseq_name": "farnesyl pyrophosphate synthase isoform X1", "refseq_ac": [ { "id": "XP_005203664", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005203664", "type": "external" } ], "gene_names_uniprotkb": "FDPS", "gene_names_refseq": "FDPS", "protein_names_uniprotkb": "Farnesyl pyrophosphate synthase; (2E,6E)-farnesyl diphosphate synthase; 2.5.1.10; 2.5.1.1; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Geranyltranstransferase", "protein_names_refseq": "farnesyl pyrophosphate synthase isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.1", "type": "external" }, { "id": "2.5.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.10", "type": "external" }, { "id": "2.5.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.29", "type": "external" }, { "id": "2.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0004161 dimethylallyltranstransferase activity;GO:0004337 (2E,6E)-farnesyl diphosphate synthase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005777 peroxisome;GO:0005829 cytosol", "go_biological_process": "GO:0006695 cholesterol biosynthetic process;GO:0008299 isoprenoid biosynthetic process;GO:0033386 geranylgeranyl diphosphate biosynthetic process;GO:0033489 cholesterol biosynthetic process via desmosterol;GO:0033490 cholesterol biosynthetic process via lathosterol", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N431-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19238-1", "uniprot_id": [ { "id": "CD5_BOVIN", "url": "https://www.uniprot.org/uniprot/P19238", "type": "external" } ], "mass": 54367.0, "length": 495, "protein_name": "T-cell surface glycoprotein CD5", "gene_name": "CD5", "organism": "Bovine", "refseq_name": "T-cell surface glycoprotein CD5 precursor", "refseq_ac": [ { "id": "NP_776324", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776324", "type": "external" } ], "gene_names_uniprotkb": "CD5", "gene_names_refseq": "CD5", "protein_names_uniprotkb": "T-cell surface glycoprotein CD5", "protein_names_refseq": "CD5 antigen (p56-62); CD74 antigen, invariant polypeptide of major; T-cell surface glycoprotein CD5 precursor; T-cell surface glycoprotein CD5", "tax_id": 9913, "disease": "", "pathway": " (bta:280745)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1698281;18692906", "class_list": "", "function": "Differential expression of CD5bright and CD5dim subpopulations on B cells in animals with paratuberculosis may reflect a shift in host immunity during the disease process., [RefSeq, PubMed]; May act as a receptor in regulating T-cell proliferation., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q2HJA1", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0031295 T cell costimulation;GO:0050859 negative regulation of B cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P19238-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O18824-1", "uniprot_id": [ { "id": "SCRB1_BOVIN", "url": "https://www.uniprot.org/uniprot/O18824", "type": "external" } ], "mass": 57610.0, "length": 509, "protein_name": "Scavenger receptor class B member 1", "gene_name": "SCARB1", "organism": "Bovine", "refseq_name": "scavenger receptor class B member 1", "refseq_ac": [ { "id": "NP_777022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777022", "type": "external" } ], "gene_names_uniprotkb": "SCARB1", "gene_names_refseq": "CD36L1; SCARB1", "protein_names_uniprotkb": "Scavenger receptor class B member 1; SR-BI; SRB1", "protein_names_refseq": "CD36 antigen (collagen type I receptor, thrombospondin receptor-like 1); SR-BI; SRB1; scavenger receptor class B member 1", "tax_id": 9913, "disease": "", "pathway": " (bta:282346); (R-BTA-3000471); (R-BTA-8964011)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "19372466;9406850", "class_list": "", "function": "Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI or ABCG1 but not ABCA1., [RefSeq, PubMed]; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 9, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070506 high-density lipoprotein particle receptor activity;GO:0005044 scavenger receptor activity;GO:0001540 amyloid-beta binding;GO:0008289 lipid binding;GO:0034186 apolipoprotein A-I binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0005901 caveola", "go_biological_process": "GO:0044406 adhesion of symbiont to host;GO:1902070 positive regulation of sphingolipid mediated signaling pathway;GO:0015914 phospholipid transport;GO:0033344 cholesterol efflux;GO:0034375 high-density lipoprotein particle remodeling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O18824-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CB32-1", "uniprot_id": [ { "id": "HS71L_BOVIN", "url": "https://www.uniprot.org/uniprot/P0CB32", "type": "external" } ], "mass": 70389.0, "length": 641, "protein_name": "Heat shock 70 kDa protein 1-like", "gene_name": "HSPA1L", "organism": "Bovine", "refseq_name": "heat shock 70 kDa protein 1-like", "refseq_ac": [ { "id": "NP_001161367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161367", "type": "external" } ], "gene_names_uniprotkb": "HSPA1L", "gene_names_refseq": "HSPA1L", "protein_names_uniprotkb": "Heat shock 70 kDa protein 1-like; Heat shock 70 kDa protein 1L", "protein_names_refseq": "Heat shock 70 kDa protein 1L; heat shock 70 kDa protein 1-like", "tax_id": 9913, "disease": "", "pathway": " (bta:540190); (R-BTA-3371453); (R-BTA-3371497); (R-BTA-3371568); (R-BTA-3371571); (R-BTA-9833482)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "30573663", "class_list": "", "function": "Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Positive regulator of PRKN translocation to damaged mitochondria., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0044297 cell body", "go_biological_process": "GO:1903955 positive regulation of protein targeting to mitochondrion;GO:0042026 protein refolding", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0CB32-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O02756-1", "uniprot_id": [ { "id": "CEBPD_BOVIN", "url": "https://www.uniprot.org/uniprot/O02756", "type": "external" } ], "mass": 27137.0, "length": 256, "protein_name": "CCAAT/enhancer-binding protein delta", "gene_name": "CEBPD", "organism": "Bovine", "refseq_name": "CCAAT/enhancer-binding protein delta", "refseq_ac": [ { "id": "NP_776692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776692", "type": "external" } ], "gene_names_uniprotkb": "CEBPD", "gene_names_refseq": "CEBPD", "protein_names_uniprotkb": "CCAAT/enhancer-binding protein delta; C/EBP delta", "protein_names_refseq": "C/EBP-delta; CCAAT/enhancer binding protein (C/EBP), delta; CCAAT/enhancer-binding protein delta; binding protein (C/EBP), delta; c/EBP delta", "tax_id": 9913, "disease": "", "pathway": " (bta:281678)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "14687085;24213926;9051484", "class_list": "", "function": "Chromosome mapping of this gene to BTA14q15-17, [RefSeq, PubMed]; Elevated C/EBPdelta can induce the adipogenesis in the fibroblasts of cattle., [RefSeq, PubMed]; Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A3KN42", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045595 regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O02756-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N6R0-1", "uniprot_id": [ { "id": "F1N6R0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N6R0", "type": "external" } ], "mass": 88726.0, "length": 761, "protein_name": "BMP/retinoic acid-inducible neural-specific protein 1", "gene_name": "BRINP1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "BRINP1", "gene_names_refseq": "", "protein_names_uniprotkb": "BMP/retinoic acid-inducible neural-specific protein 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0098978 glutamatergic synapse;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007399 nervous system development;GO:0045666 positive regulation of neuron differentiation;GO:0045930 negative regulation of mitotic cell cycle;GO:0071300 cellular response to retinoic acid;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N6R0-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77802-1", "uniprot_id": [ { "id": "ANGP2_BOVIN", "url": "https://www.uniprot.org/uniprot/O77802", "type": "external" } ], "mass": 56539.0, "length": 496, "protein_name": "Angiopoietin-2", "gene_name": "ANGPT2", "organism": "Bovine", "refseq_name": "angiopoietin-2 precursor", "refseq_ac": [ { "id": "NP_001092325", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092325", "type": "external" } ], "gene_names_uniprotkb": "ANGPT2; ANG2", "gene_names_refseq": "ANGPT2", "protein_names_uniprotkb": "Angiopoietin-2; ANG-2", "protein_names_refseq": "ANG-2; angiopoietin-2 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:282141); (R-BTA-210993)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15329480;16447257;17673702;18541291;18720385;23726425;9776732;9840613", "class_list": "", "function": "Activation of the PI3-K/Akt pathway downregulates Angiopoietin-2 reveals an additional mechanism through which the PTEN/PI3-K/Akt pathway could affect the angiogenic process. Erratum:[J Cell Physiol. 2006 Oct;209(1):239], [RefSeq, PubMed]; Ang2 produced by oscillatory shear stress in endothelial cells plays a critical role in migration/tubule formation. May have role in diseases with disturbed flow/angiogenesis., [RefSeq, PubMed]; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (By similarity). Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1 (By similarity). In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression (By similarity). In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity). Involved in the regulation of lymphangiogenesis (By similarity)., [UniProtKB, UniProtKB]; Hypoxic regulation of Ang-2 is HIF-dependent and demonstrate that HIF-1alpha binds in human microvascular endothelial cells (HMVEC) to an evolutionary conserved Hypoxia-Responsive Element (HRE) located in the first intron of the Ang-2 gene., [RefSeq, PubMed]; In mature and late regressing corpus luteum, high scores of Ang-2-immunopositive endothelial and smooth muscle cells were found., [RefSeq, PubMed]; Polymorphisms significantly associated with milk somatic cell score, [RefSeq, PubMed]; The mRNA expression for ANPT-2 was drastically decreased in the follicles with E(2)>5 ng/ml., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A5PKF7;Q9TSK0", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030971 receptor tyrosine kinase binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0001525 angiogenesis;GO:0030154 cell differentiation;GO:0007596 blood coagulation;GO:0043537 negative regulation of blood vessel endothelial cell migration;GO:0048014 Tie signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "O77802-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MYI9-1", "uniprot_id": [ { "id": "F1MYI9_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MYI9", "type": "external" } ], "mass": 32302.0, "length": 299, "protein_name": "Adipolin", "gene_name": "C1QTNF12", "organism": "Bovine", "refseq_name": "adipolin", "refseq_ac": [ { "id": "XP_002694178", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694178", "type": "external" } ], "gene_names_uniprotkb": "C1QTNF12", "gene_names_refseq": "C1QTNF12", "protein_names_uniprotkb": "Adipolin; Adipose-derived insulin-sensitizing factor; Complement C1q tumor necrosis factor-related protein 12", "protein_names_refseq": "adipolin", "tax_id": 9913, "disease": "", "pathway": " (bta:506102)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0045721 negative regulation of gluconeogenesis;GO:0046326 positive regulation of D-glucose import;GO:0046628 positive regulation of insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MYI9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MYR3-1", "uniprot_id": [ { "id": "F1MYR3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MYR3", "type": "external" } ], "mass": 60007.0, "length": 515, "protein_name": "Dynein regulatory complex subunit 4", "gene_name": "GAS8", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GAS8", "gene_names_refseq": "", "protein_names_uniprotkb": "Dynein regulatory complex subunit 4; Growth arrest-specific protein 8", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005874 microtubule;GO:0031514 motile cilium", "go_biological_process": "GO:0048870 cell motility", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MYR3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MYV2-1", "uniprot_id": [ { "id": "F1MYV2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MYV2", "type": "external" } ], "mass": 175319.0, "length": 1558, "protein_name": "Lysine-specific demethylase 5C", "gene_name": "KDM5C", "organism": "Bovine", "refseq_name": "lysine-specific demethylase 5C isoform X6", "refseq_ac": [ { "id": "XP_005228256", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228256", "type": "external" } ], "gene_names_uniprotkb": "KDM5C", "gene_names_refseq": "JARID1C; KDM5C; SMCX", "protein_names_uniprotkb": "Lysine-specific demethylase 5C; 1.14.11.67; Histone demethylase JARID1C; Jumonji/ARID domain-containing protein 1C; Protein SmcX; [histone H3]-trimethyl-L-lysine(4) demethylase 5C", "protein_names_refseq": "lysine-specific demethylase 5C isoform X6", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-3214842)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.67", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.67", "type": "external" } ], "go_molecular_function": "GO:0034647 histone H3K4me/H3K4me2/H3K4me3 demethylase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0048511 rhythmic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MYV2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MYZ5-1", "uniprot_id": [ { "id": "F1MYZ5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MYZ5", "type": "external" } ], "mass": 9371.0, "length": 84, "protein_name": "Dolichol phosphate-mannose biosynthesis regulatory protein", "gene_name": "DPM2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DPM2", "gene_names_refseq": "", "protein_names_uniprotkb": "Dolichol phosphate-mannose biosynthesis regulatory protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-162699); (R-BTA-162710)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis. May act by regulating the GPI-GNT complex., [UniProtKB, UniProtKB]; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex;GO:0033185 dolichol-phosphate-mannose synthase complex;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0043048 dolichyl monophosphate biosynthetic process;GO:0006506 GPI anchor biosynthetic process;GO:0180047 dolichol phosphate mannose biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MYZ5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MZ33-1", "uniprot_id": [ { "id": "F1MZ33_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MZ33", "type": "external" } ], "mass": 40779.0, "length": 371, "protein_name": "Deoxyribonuclease-2-alpha", "gene_name": "DNASE2", "organism": "Bovine", "refseq_name": "deoxyribonuclease-2-alpha isoform X1", "refseq_ac": [ { "id": "XP_010805020", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010805020", "type": "external" } ], "gene_names_uniprotkb": "DNASE2", "gene_names_refseq": "DNASE2", "protein_names_uniprotkb": "Deoxyribonuclease-2-alpha; 3.1.22.1; Acid DNase; Deoxyribonuclease II alpha; Lysosomal DNase II", "protein_names_refseq": "deoxyribonuclease-2-alpha isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-432720)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.1.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.1", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0004531 deoxyribonuclease II activity", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0043277 apoptotic cell clearance;GO:0006309 apoptotic DNA fragmentation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MZ33-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MZD4-1", "uniprot_id": [ { "id": "F1MZD4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MZD4", "type": "external" } ], "mass": 161138.0, "length": 1437, "protein_name": "ATP-binding cassette sub-family C member 5", "gene_name": "ABCC5", "organism": "Bovine", "refseq_name": "ATP-binding cassette sub-family C member 5 isoform X1", "refseq_ac": [ { "id": "XP_005201642", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005201642", "type": "external" } ], "gene_names_uniprotkb": "ABCC5", "gene_names_refseq": "ABCC5", "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 5; 7.6.2.2; Multidrug resistance-associated protein 5", "protein_names_refseq": "ATP-binding cassette sub-family C member 5 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:511769); (R-BTA-2142845); (R-BTA-382556); (R-BTA-9748787); (R-BTA-9753281)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2", "type": "external" }, { "id": "7.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3", "type": "external" }, { "id": "7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008559 ABC-type xenobiotic transporter activity;GO:0015232 heme transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0015216 purine nucleotide transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0098838 folate transmembrane transport;GO:0030213 hyaluronan biosynthetic process;GO:0140115 export across plasma membrane;GO:0035351 heme transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MZD4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MZH1-1", "uniprot_id": [ { "id": "F1MZH1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MZH1", "type": "external" } ], "mass": 41911.0, "length": 394, "protein_name": "E3 ubiquitin-protein ligase NHLRC1", "gene_name": "NHLRC1", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase NHLRC1", "refseq_ac": [ { "id": "XP_002697596", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697596", "type": "external" } ], "gene_names_uniprotkb": "NHLRC1", "gene_names_refseq": "NHLRC1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase NHLRC1; 2.3.2.27; Malin; NHL repeat-containing protein 1; RING-type E3 ubiquitin transferase NHLRC1", "protein_names_refseq": "E3 ubiquitin-protein ligase NHLRC1", "tax_id": 9913, "disease": "", "pathway": " (bta:538814)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006914 autophagy;GO:0005978 glycogen biosynthetic process;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MZH1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MZK0-1", "uniprot_id": [ { "id": "F1MZK0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MZK0", "type": "external" } ], "mass": 56805.0, "length": 496, "protein_name": "Glycylpeptide N-tetradecanoyltransferase", "gene_name": "NMT1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NMT1", "gene_names_refseq": "", "protein_names_uniprotkb": "Glycylpeptide N-tetradecanoyltransferase; 2.3.1.97", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2514859); (R-BTA-75108)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.97", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.97", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0004379 glycylpeptide N-tetradecanoyltransferase activity;GO:0018030 peptidyl-lysine N6-myristoyltransferase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0042180 ketone metabolic process;GO:0072657 protein localization to membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MZK0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MZM9-1", "uniprot_id": [ { "id": "F1MZM9_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MZM9", "type": "external" } ], "mass": 62851.0, "length": 550, "protein_name": "Hyaluronidase", "gene_name": "LOC509761", "organism": "Bovine", "refseq_name": "hyaluronidase PH-20", "refseq_ac": [ { "id": "XP_002686960", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686960", "type": "external" } ], "gene_names_uniprotkb": "LOC509761", "gene_names_refseq": "LOC509761", "protein_names_uniprotkb": "Hyaluronidase; 3.2.1.35", "protein_names_refseq": "hyaluronidase PH-20", "tax_id": 9913, "disease": "", "pathway": " (bta:509761); (R-BTA-2160916); (R-BTA-2534343)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.35", "type": "external" } ], "go_molecular_function": "GO:0004415 hyalurononglucosaminidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001669 acrosomal vesicle;GO:0098552 side of membrane", "go_biological_process": "GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization;GO:0005975 carbohydrate metabolic process;GO:0030214 hyaluronan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MZM9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MZQ5-1", "uniprot_id": [ { "id": "F1MZQ5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MZQ5", "type": "external" } ], "mass": 40807.0, "length": 360, "protein_name": "Ig-like domain-containing protein", "gene_name": "BoLA", "organism": "Bovine", "refseq_name": "major histocompatibility complex, class I, A isoform X5", "refseq_ac": [ { "id": "XP_005223758", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223758", "type": "external" } ], "gene_names_uniprotkb": "BoLA", "gene_names_refseq": "BoLA-NC; 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Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" }, { "id": "1.14.13.148", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.148", "type": "external" }, { "id": "1.14.13.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.8", "type": "external" }, { "id": "1.14.13.32", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.32", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0050661 NADP binding;GO:0004499 N,N-dimethylaniline monooxygenase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N007-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N083-1", "uniprot_id": [ { "id": "F1N083_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N083", "type": "external" } ], "mass": 40693.0, "length": 372, "protein_name": "Opioid receptor delta 1", "gene_name": "OPRD1", "organism": "Bovine", "refseq_name": "delta-type opioid receptor", "refseq_ac": [ { "id": "NP_001178077", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178077", "type": "external" } ], "gene_names_uniprotkb": "OPRD1", "gene_names_refseq": "OPRD1", "protein_names_uniprotkb": "Opioid receptor delta 1", "protein_names_refseq": "delta-type opioid receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:781956); 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Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. 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"go_biological_process": "GO:0032759 positive regulation of TRAIL production;GO:0007165 signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0032760 positive regulation of tumor necrosis factor production;GO:0071260 cellular response to mechanical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N0U5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N0X6-1", "uniprot_id": [ { "id": "F1N0X6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N0X6", "type": "external" } ], "mass": 114407.0, "length": 1013, "protein_name": "Metalloendopeptidase", "gene_name": "TLL1", "organism": "Bovine", "refseq_name": "tolloid-like protein 1 precursor", "refseq_ac": [ { "id": "NP_001180043", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180043", "type": "external" } ], "gene_names_uniprotkb": "TLL1", "gene_names_refseq": "TLL1", 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"secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule;GO:0005871 kinesin complex", "go_biological_process": "GO:0051301 cell division;GO:0007018 microtubule-based movement;GO:0007019 microtubule depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N0Y3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N157-1", "uniprot_id": [ { "id": "F1N157_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N157", "type": "external" } ], "mass": 133243.0, "length": 1189, "protein_name": "Integrin subunit alpha 11", "gene_name": "ITGA11", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ITGA11", "gene_names_refseq": "", "protein_names_uniprotkb": "Integrin subunit alpha 11", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0038023 signaling receptor activity;GO:0038064 collagen receptor activity;GO:0098639 collagen binding involved in cell-matrix adhesion", "go_cellular_component": "GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0034681 integrin alpha11-beta1 complex", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0033627 cell adhesion mediated by integrin;GO:0098609 cell-cell adhesion;GO:0006929 substrate-dependent cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N157-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N165-1", "uniprot_id": [ { "id": "F1N165_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N165", "type": "external" } ], "mass": 30570.0, "length": 253, "protein_name": "U3 small nucleolar RNA-associated protein 11", "gene_name": "UTP11", "organism": "Bovine", "refseq_name": "probable U3 small nucleolar RNA-associated protein 11 isoform X1", "refseq_ac": [ { "id": "XP_010801975", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010801975", "type": "external" } ], "gene_names_uniprotkb": "UTP11", "gene_names_refseq": "UTP11", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein 11; U3 snoRNA-associated protein 11", "protein_names_refseq": "probable U3 small nucleolar RNA-associated protein 11 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-6791226)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in nucleolar processing of pre-18S ribosomal RNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0032040 small-subunit processome", "go_biological_process": "GO:0007399 nervous system development;GO:0043065 positive regulation of apoptotic process;GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N165-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N173-1", "uniprot_id": [ { "id": "F1N173_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N173", "type": "external" } ], "mass": 208405.0, "length": 1878, "protein_name": "Plexin-A3", "gene_name": "PLXNA3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PLXNA3", "gene_names_refseq": "", "protein_names_uniprotkb": "Plexin-A3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-399954); (R-BTA-399955); (R-BTA-399956)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017154 semaphorin receptor activity", "go_cellular_component": "GO:0002116 semaphorin receptor complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0051495 positive regulation of cytoskeleton organization;GO:0071526 semaphorin-plexin signaling pathway;GO:0007416 synapse assembly;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N173-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N1F5-1", "uniprot_id": [ { "id": "F1N1F5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N1F5", "type": "external" } ], "mass": 61523.0, "length": 558, "protein_name": "Matrix metalloproteinase-25", "gene_name": "MMP25", "organism": "Bovine", "refseq_name": "matrix metalloproteinase-25 isoform X1", "refseq_ac": [ { "id": "XP_010817533", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010817533", "type": "external" } ], "gene_names_uniprotkb": "MMP25", "gene_names_refseq": "MMP25", "protein_names_uniprotkb": "Matrix metalloproteinase-25", "protein_names_refseq": "matrix metalloproteinase-25 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:531092); (R-BTA-1592389); (R-BTA-6798695)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May activate progelatinase A., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0098552 side of membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N1F5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N1G6-1", "uniprot_id": [ { "id": "F1N1G6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N1G6", "type": "external" } ], "mass": 40651.0, "length": 371, "protein_name": "4-hydroxybenzoate polyprenyltransferase, mitochondrial", "gene_name": "COQ2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "COQ2", "gene_names_refseq": "", "protein_names_uniprotkb": "4-hydroxybenzoate polyprenyltransferase, mitochondrial; 2.5.1.39; 4-HB polyprenyltransferase; PHB:PPT; PHB:polyprenyltransferase; Para-hydroxybenzoate--polyprenyltransferase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1268020); (R-BTA-2142789)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.3.3", "type": "external" }, { "id": "2.5.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.39", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" } ], "go_molecular_function": "GO:0008412 4-hydroxybenzoate polyprenyltransferase activity", "go_cellular_component": "GO:0031314 extrinsic component of mitochondrial inner membrane;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process;GO:0006071 glycerol metabolic process;GO:0008299 isoprenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N1G6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N1K1-1", "uniprot_id": [ { "id": "F1N1K1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N1K1", "type": "external" } ], "mass": 23943.0, "length": 217, "protein_name": "Homeobox protein Hox-B7", "gene_name": "HOXB7", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HOXB7", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein Hox-B7", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification;GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis;GO:0048568 embryonic organ development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N1K1-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N1Q0-1", "uniprot_id": [ { "id": "F1N1Q0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N1Q0", "type": "external" } ], "mass": 55400.0, "length": 494, "protein_name": "Tyrosine-protein kinase", "gene_name": "SRMS", "organism": "Bovine", "refseq_name": "tyrosine-protein kinase Srms", "refseq_ac": [ { "id": "NP_001179473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179473", "type": "external" } ], "gene_names_uniprotkb": "SRMS", "gene_names_refseq": "SRMS", "protein_names_uniprotkb": "Tyrosine-protein kinase; 2.7.10.2", "protein_names_refseq": "tyrosine-protein kinase Srms", "tax_id": 9913, "disease": "", "pathway": " (bta:521816); (R-BTA-8849472)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues. Phosphorylation of KHDRBS1 is EGF-dependent. Phosphorylates OTUB1, promoting deubiquitination of RPTOR., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, 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activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N1Q0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N1Q2-1", "uniprot_id": [ { "id": "F1N1Q2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N1Q2", "type": "external" } ], "mass": 80905.0, "length": 727, "protein_name": "Transporter", "gene_name": "SLC6A17", "organism": "Bovine", "refseq_name": "sodium-dependent neutral amino acid transporter SLC6A17", "refseq_ac": [ { "id": "NP_001160045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160045", "type": "external" } ], 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"organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RAB8B", "gene_names_refseq": "", "protein_names_uniprotkb": "small monomeric GTPase; 3.6.5.2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-8854214); (R-BTA-8873719); (R-BTA-8876198)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005102 signaling receptor binding;GO:0005525 GTP binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005768 endosome;GO:0005778 peroxisomal membrane;GO:0005886 plasma membrane;GO:0030670 phagocytic vesicle membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0006887 exocytosis;GO:0032456 endocytic recycling;GO:0045046 protein import into peroxisome membrane;GO:0019882 antigen processing and presentation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N2J9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N2X0-1", "uniprot_id": [ { "id": "F1N2X0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N2X0", "type": "external" } ], "mass": 52061.0, "length": 463, "protein_name": "Neuromedin-K receptor", "gene_name": "TACR3", "organism": "Bovine", "refseq_name": "neuromedin-K receptor", "refseq_ac": [ { "id": "NP_001179262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179262", "type": "external" } ], "gene_names_uniprotkb": "TACR3", "gene_names_refseq": "TACR3", "protein_names_uniprotkb": "Neuromedin-K receptor; NK-3 receptor; Neurokinin B receptor; Tachykinin receptor 3", "protein_names_refseq": "neurokinin-3 receptor; neuromedin-K receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:404136); (R-BTA-380095); (R-BTA-416476)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004995 tachykinin receptor activity;GO:0016498 neuromedin K receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0097225 sperm midpiece", "go_biological_process": "GO:1902093 positive regulation of flagellated sperm motility;GO:0007209 phospholipase C-activating tachykinin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N2X0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N2Y8-1", "uniprot_id": [ { "id": "F1N2Y8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N2Y8", "type": "external" } ], "mass": 145544.0, "length": 1347, "protein_name": "Neurocan core protein", "gene_name": "NCAN", "organism": "Bovine", "refseq_name": "neurocan core protein precursor", "refseq_ac": [ { "id": "NP_001180011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180011", "type": "external" } ], "gene_names_uniprotkb": "NCAN", "gene_names_refseq": "NCAN", "protein_names_uniprotkb": "Neurocan core protein; Chondroitin sulfate proteoglycan 3", "protein_names_refseq": "neurocan core protein precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:523701); (R-BTA-1971475); (R-BTA-2022870); (R-BTA-2022923); (R-BTA-2024101); (R-BTA-3000178)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0045202 synapse;GO:0072534 perineuronal net", "go_biological_process": "GO:0007155 cell adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N2Y8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N303-1", "uniprot_id": [ { "id": "F1N303_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N303", "type": "external" } ], "mass": 133898.0, "length": 1209, "protein_name": "ADAM metallopeptidase with thrombospondin type 1 motif 19", "gene_name": "ADAMTS19", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ADAMTS19", "gene_names_refseq": "", "protein_names_uniprotkb": "ADAM metallopeptidase with thrombospondin type 1 motif 19", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5173214)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030199 collagen fibril organization;GO:0003180 aortic valve morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N303-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N332-1", "uniprot_id": [ { "id": "F1N332_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N332", "type": "external" } ], "mass": 53479.0, "length": 473, "protein_name": "Serine/threonine-protein kinase ULK3", "gene_name": "ULK3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ULK3", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase ULK3; 2.7.11.1; Unc-51-like kinase 3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5632684)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005776 autophagosome;GO:0034045 phagophore assembly site membrane;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0000045 autophagosome assembly;GO:0010506 regulation of autophagy;GO:0042594 response to starvation;GO:0007224 smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N332-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N368-1", "uniprot_id": [ { "id": "F1N368_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N368", "type": "external" } ], "mass": 246726.0, "length": 2366, "protein_name": "Aggrecan core protein", "gene_name": "ACAN", "organism": "Bovine", "refseq_name": "aggrecan core protein isoform X2", "refseq_ac": [ { "id": "XP_024837356", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837356", "type": "external" } ], "gene_names_uniprotkb": "ACAN", "gene_names_refseq": "ACAN; AGC1", "protein_names_uniprotkb": "Aggrecan core protein; Cartilage-specific proteoglycan core protein", "protein_names_refseq": "aggrecan core protein isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:280985); (R-BTA-1474228); (R-BTA-2022854); (R-BTA-2022857); (R-BTA-3000178)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. 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Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, 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"hit_score": 0.1, "record_id": "F1N3J3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N3M7-1", "uniprot_id": [ { "id": "F1N3M7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N3M7", "type": "external" } ], "mass": 21110.0, "length": 189, "protein_name": "COMM domain-containing protein 1", "gene_name": "COMMD1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "COMMD1", "gene_names_refseq": "", "protein_names_uniprotkb": "COMM domain-containing protein 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-8951664)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 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"0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N428-1", "uniprot_id": [ { "id": "F1N428_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N428", "type": "external" } ], "mass": 72310.0, "length": 659, "protein_name": "Sodium/nucleoside cotransporter", "gene_name": "SLC28A2", "organism": "Bovine", "refseq_name": "sodium/nucleoside cotransporter 2", "refseq_ac": [ { "id": "XP_002690952", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690952", "type": "external" } ], "gene_names_uniprotkb": "SLC28A2", "gene_names_refseq": "SLC28A2", "protein_names_uniprotkb": "Sodium/nucleoside cotransporter", "protein_names_refseq": "sodium/nucleoside cotransporter 2", "tax_id": 9913, "disease": "", "pathway": " (bta:531921); (R-BTA-83936); (R-BTA-9748787); (R-BTA-9755088)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, 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{ "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0050727 regulation of inflammatory response;GO:0070979 protein K11-linked ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:1990390 protein K33-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N495-1", 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Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004642 phosphoribosylformylglycinamidine synthase activity;GO:0016874 ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006177 GMP biosynthetic process;GO:0006189 'de novo' IMP biosynthetic process;GO:0044208 'de novo' AMP biosynthetic process;GO:0097294 'de novo' XMP biosynthetic process;GO:0006164 purine nucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N4K1-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N4M2-1", "uniprot_id": [ { "id": "MRFL_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N4M2", "type": "external" } ], "mass": 100085.0, "length": 896, "protein_name": "Myelin regulatory factor-like protein", "gene_name": "MYRFL", "organism": "Bovine", "refseq_name": "myelin regulatory factor-like protein", "refseq_ac": [ { "id": "NP_001095793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095793", "type": "external" } ], "gene_names_uniprotkb": "MYRFL", "gene_names_refseq": "C5H12orf28; MYRFL", "protein_names_uniprotkb": "Myelin regulatory factor-like protein", "protein_names_refseq": "myelin regulatory factor-like protein", "tax_id": 9913, "disease": "", "pathway": " (bta:781109)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QNP2", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0043565 sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0016540 protein autoprocessing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1N4M2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N4T3-1", "uniprot_id": [ { "id": "F1N4T3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N4T3", "type": "external" } ], "mass": 57801.0, "length": 506, "protein_name": "Cholinergic receptor nicotinic alpha 2 subunit", "gene_name": "CHRNA2", "organism": "Bovine", "refseq_name": "neuronal acetylcholine receptor subunit alpha-2 precursor", "refseq_ac": [ { "id": "NP_001179639", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179639", "type": "external" } ], "gene_names_uniprotkb": "CHRNA2", "gene_names_refseq": "CHRNA2", "protein_names_uniprotkb": "Cholinergic receptor nicotinic alpha 2 subunit", "protein_names_refseq": "cholinergic receptor, nicotinic, alpha 2 (neuronal); neuronal acetylcholine receptor subunit alpha-2 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:531838); (R-BTA-629594); (R-BTA-629597)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0035094 response to nicotine;GO:0095500 acetylcholine receptor signaling pathway;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N4T3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N4U9-1", "uniprot_id": [ { "id": "F1N4U9_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N4U9", "type": "external" } ], "mass": 43375.0, "length": 382, "protein_name": "L-selectin", "gene_name": "SELL", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SELL", "gene_names_refseq": "", "protein_names_uniprotkb": "L-selectin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0002020 protease binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050901 leukocyte tethering or rolling;GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N4U9-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N4V2-1", "uniprot_id": [ { "id": "F1N4V2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N4V2", "type": "external" } ], "mass": 133346.0, "length": 1173, "protein_name": "RNA polymerase-associated protein CTR9 homolog", "gene_name": "CTR9", "organism": "Bovine", "refseq_name": "RNA polymerase-associated protein CTR9 homolog", "refseq_ac": [ { "id": "NP_001192326", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192326", "type": "external" } ], "gene_names_uniprotkb": "CTR9", "gene_names_refseq": "CTR9", "protein_names_uniprotkb": "RNA polymerase-associated protein CTR9 homolog; SH2 domain-binding protein 1", "protein_names_refseq": "Ctr9, Paf1/RNA polymerase II complex component, homolog; RNA polymerase-associated protein CTR9 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:534265); (R-BTA-674695); (R-BTA-75955); (R-BTA-8866654); (R-BTA-9943411)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042169 SH2 domain binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0016607 nuclear speck;GO:0000791 euchromatin;GO:0016593 Cdc73/Paf1 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071222 cellular response to lipopolysaccharide;GO:0006325 chromatin organization;GO:0019827 stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N4V2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N4Z6-1", "uniprot_id": [ { "id": "F1N4Z6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N4Z6", "type": "external" } ], "mass": 59732.0, "length": 544, "protein_name": "Solute carrier family 11 member 1", "gene_name": "LOC112441543", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LOC112441543", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 11 member 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046870 cadmium ion binding;GO:0005384 manganese ion transmembrane transporter activity;GO:0015087 cobalt ion transmembrane transporter activity;GO:0015093 ferrous iron transmembrane transporter activity;GO:0015094 lead ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0034755 iron ion transmembrane transport;GO:0006879 intracellular iron ion homeostasis;GO:0006828 manganese ion transport;GO:0030026 intracellular manganese ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N4Z6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N513-1", "uniprot_id": [ { "id": "F1N513_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N513", "type": "external" } ], "mass": 109379.0, "length": 980, "protein_name": "SLIT and NTRK like family member 3", "gene_name": "SLITRK3", "organism": "Bovine", "refseq_name": "SLIT and NTRK-like protein 3", "refseq_ac": [ { "id": "XP_003585735", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003585735", "type": "external" } ], "gene_names_uniprotkb": "SLITRK3", "gene_names_refseq": "SLITRK3", "protein_names_uniprotkb": "SLIT and NTRK like family member 3", "protein_names_refseq": "SLIT and NTRK-like protein 3", "tax_id": 9913, "disease": "", "pathway": " (bta:527364); (R-BTA-388844); (R-BTA-9013423)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0009986 cell surface;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0007409 axonogenesis;GO:0051965 positive regulation of synapse assembly;GO:0099560 synaptic membrane adhesion;GO:1905606 regulation of presynapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N513-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N533-1", "uniprot_id": [ { "id": "F1N533_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N533", "type": "external" } ], "mass": 84443.0, "length": 760, "protein_name": "ATP-dependent RNA helicase", "gene_name": "DDX18", "organism": "Bovine", "refseq_name": "ATP-dependent RNA helicase DDX18", "refseq_ac": [ { "id": "XP_005202604", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005202604", "type": "external" } ], "gene_names_uniprotkb": "DDX18", "gene_names_refseq": "DDX18", "protein_names_uniprotkb": "ATP-dependent RNA helicase; 3.6.4.13", "protein_names_refseq": "ATP-dependent RNA helicase DDX18", "tax_id": 9913, "disease": "", "pathway": " (bta:519254)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ATP-dependent RNA helicase that plays a role in the regulation of R-loop homeostasis in both endogenous R-loop-prone regions and at sites of DNA damage. At endogenous loci such as actively transcribed genes, may act as a helicase to resolve the formation of R-loop during transcription and prevent the interference of R-loop with DNA-replication machinery. Also participates in the removal of DNA-lesion-associated R-loop. Plays an essential role for establishing pluripotency during embryogenesis and for pluripotency maintenance in embryonic stem cells. Mechanistically, prevents the polycomb repressive complex 2 (PRC2) from accessing rDNA loci and protects the active chromatin status in nucleolus., [UniProtKB, UniProtKB]; RNA helicase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N533-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N551-1", "uniprot_id": [ { "id": "F1N551_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N551", "type": "external" } ], "mass": 44539.0, "length": 442, "protein_name": "Transcription factor GATA-4", "gene_name": "GATA4", "organism": "Bovine", "refseq_name": "transcription factor GATA-4", "refseq_ac": [ { "id": "NP_001179806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179806", "type": "external" } ], "gene_names_uniprotkb": "GATA4", "gene_names_refseq": "GATA4", "protein_names_uniprotkb": "Transcription factor GATA-4; GATA-binding factor 4", "protein_names_refseq": "transcription factor GATA-4", "tax_id": 9913, "disease": "", "pathway": " (bta:327716); (R-BTA-983231)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "22056786", "class_list": "", "function": "The activity of Gata4 cardiac enhancer in transgenic embryos and in cultured aortic endothelial cells is dependent on four ETS sites., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070410 co-SMAD binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0003290 atrial septum secundum morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1N551-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N557-1", "uniprot_id": [ { "id": "F1N557_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N557", "type": "external" } ], "mass": 55717.0, "length": 478, "protein_name": "GDP-fucose protein O-fucosyltransferase", "gene_name": "FUT10", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FUT10", "gene_names_refseq": "", "protein_names_uniprotkb": "GDP-fucose protein O-fucosyltransferase; 2.4.1.-", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5173105)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein O-fucosyltransferase that specifically catalyzes O-fucosylation of serine or threonine residues in EMI domains of target proteins, such as MMRN1, MMRN2 and EMID1. Attaches fucose through an O-glycosidic linkage. O-fucosylation of EMI domain-containing proteins may be required for facilitating protein folding and secretion. May also show alpha-(1,3)-fucosyltransferase activity toward the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. However, this was tested with a library of synthetic substrates and this activity is unsure in vivo. May be involved in biosynthesis of Lewis X-carrying biantennary N-glycans that regulate neuron stem cell self-renewal during brain development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.221", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.221", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0046922 peptide-O-fucosyltransferase activity;GO:0046920 alpha-(1->3)-fucosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0050714 positive regulation of protein secretion;GO:0006491 N-glycan processing;GO:0036445 neuronal stem cell division", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N557-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N5L1-1", "uniprot_id": [ { "id": "F1N5L1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N5L1", "type": "external" } ], "mass": 52577.0, "length": 472, "protein_name": "Cysteine protease", "gene_name": "ATG4D", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ATG4D", "gene_names_refseq": "", "protein_names_uniprotkb": "Cysteine protease; 3.4.22.-", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1632852)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" } ], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0019786 protein-phosphatidylethanolamide deconjugating activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0015031 protein transport;GO:0016485 protein processing;GO:0034497 protein localization to phagophore assembly site;GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N5L1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N5P6-1", "uniprot_id": [ { "id": "F1N5P6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N5P6", "type": "external" } ], "mass": 67892.0, "length": 629, "protein_name": "Solute carrier family 7 member 1", "gene_name": "SLC7A1", "organism": "Bovine", "refseq_name": "high affinity cationic amino acid transporter 1", "refseq_ac": [ { "id": "NP_001129264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129264", "type": "external" } ], "gene_names_uniprotkb": "SLC7A1", "gene_names_refseq": "CAT-1; CAT1; SLC7A1", "protein_names_uniprotkb": "Solute carrier family 7 member 1", "protein_names_refseq": "high affinity cationic amino acid transporter 1; solute carrier family 7 (cationic amino acid transporter, y+ system), member 1; system Y+ basic amino acid transporter", "tax_id": 9913, "disease": "", "pathway": " (bta:539465); (R-BTA-352230)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "21239536;32321527", "class_list": "", "function": "Lipopolysaccharide/tumor necrosis factor-alpha treatment increased the expression of iNOS, arginase II, CAT-1, and CAT-2 mRNA. Erratum:[Am J Physiol Lung Cell Mol Physiol. 2011 Jul;301(1):L135. Chicione, Louis G [corrected to Chicoine, Louis G]], [RefSeq, PubMed]; Overexpression of bovine leukemia virus receptor SLC7A1/CAT1 enhances cellular susceptibility to BLV infection on luminescence syncytium induction assay (LuSIA). Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000064 L-ornithine transmembrane transporter activity;GO:0001618 virus receptor activity;GO:0015189 L-lysine transmembrane transporter activity;GO:0005290 L-histidine transmembrane transporter activity;GO:0061459 L-arginine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0097638 L-arginine import across plasma membrane;GO:0015819 lysine transport;GO:1903810 L-histidine import across plasma membrane;GO:1903352 L-ornithine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1N5P6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N5R3-1", "uniprot_id": [ { "id": "F1N5R3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N5R3", "type": "external" } ], "mass": 88472.0, "length": 773, "protein_name": "Polycystin-2-like protein 1", "gene_name": "PKD2L1", "organism": "Bovine", "refseq_name": "polycystin-2-like protein 1 isoform X2", "refseq_ac": [ { "id": "XP_015316200", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015316200", "type": "external" } ], "gene_names_uniprotkb": "PKD2L1", "gene_names_refseq": "PKD2L1", "protein_names_uniprotkb": "Polycystin-2-like protein 1; Polycystic kidney disease 2-like 1 protein; Polycystin-2 homolog", "protein_names_refseq": "polycystin-2-like protein 1 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:521231)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0005262 calcium channel activity;GO:0005509 calcium ion binding;GO:0005272 sodium channel activity;GO:0015269 calcium-activated potassium channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0031410 cytoplasmic vesicle;GO:0034704 calcium channel complex;GO:0060170 ciliary membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0051262 protein tetramerization;GO:0050915 sensory perception of sour taste;GO:0050982 detection of mechanical stimulus;GO:0071805 potassium ion transmembrane transport;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N5R3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N5S9-1", "uniprot_id": [ { "id": "FUND1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N5S9", "type": "external" } ], "mass": 17173.0, "length": 155, "protein_name": "FUN14 domain-containing protein 1", "gene_name": "FUNDC1", "organism": "Bovine", "refseq_name": "FUN14 domain-containing protein 1", "refseq_ac": [ { "id": "NP_001098452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098452", "type": "external" } ], "gene_names_uniprotkb": "FUNDC1", "gene_names_refseq": "FUNDC1", "protein_names_uniprotkb": "FUN14 domain-containing protein 1", "protein_names_refseq": "FUN14 domain-containing protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:518258); (R-BTA-8934903)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19393038;31213272", "class_list": "", "function": "Integral mitochondrial outer-membrane protein that mediates the formation of mitochondria-associated endoplasmic reticulum membranes (MAMs). In turn, mediates angiogenesis and neoangiogenesis through interference with intracellular Ca(2+) communication and regulation of the vascular endothelial growth factor receptor KDR/VEGFR2 expression at both mRNA and protein levels. Also acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality and homeostasis, by interacting with and recruiting LC3 protein family to mitochondria. Mechanistically, recruits DRP1 at ER-mitochondria contact sites leading to DRP1 oligomerization and GTPase activity to facilitate mitochondrial fission during hypoxia. Additionally, plays a role in hepatic ferroptosis by interacting directly with glutathione peroxidase/GPX4 to facilitate its recruitment into mitochondria through TOM/TIM complex where it is degraded by mitophagy., [UniProtKB, UniProtKB]; We observed that both transcript and protein levels of FUNDC1 were decreased in bovine papillomavirus-infected neoplastic bladder cells.It is conceivable that FUNDC1 plays a central role in mitochondrion fragmentation via phosphorylated DRP1 as observed in our study., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QQX3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0001666 response to hypoxia;GO:0000422 autophagy of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1N5S9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N5V2-1", "uniprot_id": [ { "id": "F1N5V2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N5V2", "type": "external" } ], "mass": 94327.0, "length": 837, "protein_name": "Taste receptor type 1 member 2", "gene_name": "TAS1R2", "organism": "Bovine", "refseq_name": "taste receptor type 1 member 2 precursor", "refseq_ac": [ { "id": "NP_001193458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193458", "type": "external" } ], "gene_names_uniprotkb": "TAS1R2", "gene_names_refseq": "TAS1R2", "protein_names_uniprotkb": "Taste receptor type 1 member 2; Sweet taste receptor T1R2", "protein_names_refseq": "taste receptor type 1 member 2 precursor; taste receptor, type 1, member 2", "tax_id": 9913, "disease": "", "pathway": " (bta:529847); (R-BTA-418594); (R-BTA-420499); (R-BTA-9717207)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative taste receptor. 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0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033041 sweet taste receptor activity", "go_cellular_component": "GO:1903767 sweet taste receptor complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0032467 positive regulation of cytokinesis;GO:0050916 sensory perception of sweet taste", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N5V2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N645-1", "uniprot_id": [ { "id": "F1N645_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N645", "type": "external" } ], "mass": 176494.0, "length": 1578, "protein_name": "HECT-type E3 ubiquitin transferase", 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"https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0072686 mitotic spindle", "go_biological_process": "GO:0048814 regulation of dendrite morphogenesis;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0030071 regulation of mitotic metaphase/anaphase transition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N645-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N694-1", "uniprot_id": [ { "id": "F1N694_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N694", "type": "external" } ], "mass": 46037.0, "length": 444, "protein_name": "Forkhead box F2", "gene_name": "FOXF2", "organism": "Bovine", "refseq_name": "forkhead box protein F2", "refseq_ac": [ { "id": "XP_003587799", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587799", "type": "external" } ], "gene_names_uniprotkb": "FOXF2", "gene_names_refseq": "FOXF2", "protein_names_uniprotkb": "Forkhead box F2", "protein_names_refseq": "forkhead box protein F2", "tax_id": 9913, "disease": "", "pathway": " (bta:529218)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, 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DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0048806 genitalia development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009887 animal organ morphogenesis;GO:0060021 roof of mouth development;GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N694-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N6A7-1", "uniprot_id": [ { "id": "F1N6A7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N6A7", "type": "external" } ], "mass": 21450.0, "length": 189, "protein_name": "Interferon alpha 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Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N6A7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N6C1-1", "uniprot_id": [ { "id": "F1N6C1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N6C1", "type": "external" } ], "mass": 224766.0, "length": 2015, "protein_name": "Leucine-rich repeat serine/threonine-protein kinase 1", "gene_name": "LRRK1", "organism": "Bovine", "refseq_name": "leucine-rich repeat serine/threonine-protein kinase 1", "refseq_ac": [ { "id": "NP_001192703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192703", "type": "external" } ], "gene_names_uniprotkb": "LRRK1", "gene_names_refseq": "LRRK1", "protein_names_uniprotkb": "Leucine-rich repeat serine/threonine-protein kinase 1; 2.7.11.1", "protein_names_refseq": "leucine-rich repeat serine/threonine-protein kinase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:513994); (R-BTA-2672351)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine-protein kinase which phosphorylates RAB proteins involved in intracellular trafficking. Phosphorylates RAB7A; this activity is dependent on protein kinase C (PKC) activation. Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, 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"2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N6C1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N6D4-1", "uniprot_id": [ { "id": "F1N6D4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N6D4", "type": "external" } ], "mass": 75848.0, "length": 693, "protein_name": "Sodium-dependent phosphate transport protein 2B", "gene_name": "SLC34A2", "organism": "Bovine", "refseq_name": "sodium-dependent phosphate transport protein 2B isoform X1", "refseq_ac": [ { "id": "XP_005207803", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207803", "type": "external" } ], "gene_names_uniprotkb": "SLC34A2", "gene_names_refseq": "SLC34A2", "protein_names_uniprotkb": "Sodium-dependent phosphate transport protein 2B; Na(+)-dependent phosphate cotransporter 2B; Sodium/phosphate cotransporter 2B; Solute carrier family 34 member 2", "protein_names_refseq": "sodium-dependent phosphate transport protein 2B isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in actively transporting phosphate into cells via Na(+) cotransport., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0031402 sodium ion binding;GO:0005436 sodium:phosphate symporter activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005903 brush border;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0043627 response to estrogen;GO:0030643 intracellular phosphate ion homeostasis;GO:0044341 sodium-dependent phosphate transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N6D4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N6E1-1", "uniprot_id": [ { "id": "F1N6E1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N6E1", "type": "external" } ], "mass": 44709.0, "length": 384, "protein_name": "Protein salvador homolog 1", "gene_name": "SAV1", "organism": "Bovine", "refseq_name": "protein salvador homolog 1", "refseq_ac": [ { "id": "NP_001178291", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178291", "type": "external" } ], "gene_names_uniprotkb": "SAV1", "gene_names_refseq": "SAV1", "protein_names_uniprotkb": "Protein salvador homolog 1; 45 kDa WW domain protein", "protein_names_refseq": "protein salvador homolog 1; salvador homolog 1", "tax_id": 9913, "disease": "", "pathway": " (bta:516557); (R-BTA-2028269)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0140537 transcription regulator activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0035329 hippo signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N6E1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N6X2-1", "uniprot_id": [ { "id": "F1N6X2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N6X2", "type": "external" } ], "mass": 65397.0, "length": 585, "protein_name": "Glutamate decarboxylase 2", "gene_name": "GAD2", "organism": "Bovine", "refseq_name": "glutamate decarboxylase 2", "refseq_ac": [ { "id": "NP_001192652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192652", "type": "external" } ], "gene_names_uniprotkb": "GAD2", "gene_names_refseq": "GAD2", "protein_names_uniprotkb": "Glutamate decarboxylase 2; 4.1.1.15; 65 kDa glutamic acid decarboxylase; Glutamate decarboxylase 65 kDa isoform", "protein_names_refseq": "glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); glutamate decarboxylase 2", "tax_id": 9913, "disease": "", "pathway": " (bta:512459); (R-BTA-888568); (R-BTA-888590)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the production of GABA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.15", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004351 glutamate decarboxylase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0006540 gamma-aminobutyrate shunt;GO:0009449 gamma-aminobutyric acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N6X2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N6X9-1", "uniprot_id": [ { "id": "F1N6X9_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N6X9", "type": "external" } ], "mass": 56515.0, "length": 515, "protein_name": "sphingomyelin phosphodiesterase", "gene_name": "SMPD5", "organism": "Bovine", "refseq_name": "sphingomyelin phosphodiesterase 5 isoform X1", "refseq_ac": [ { "id": "XP_059730316", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059730316", "type": "external" } ], "gene_names_uniprotkb": "SMPD5", "gene_names_refseq": "SMPD5", "protein_names_uniprotkb": "sphingomyelin phosphodiesterase; 3.1.4.12", "protein_names_refseq": "sphingomyelin phosphodiesterase 5 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.12", "type": "external" }, { "id": "3.1.4.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.38", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" } ], "go_molecular_function": "GO:0004620 phospholipase activity;GO:0004767 sphingomyelin phosphodiesterase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046513 ceramide biosynthetic process;GO:0006685 sphingomyelin catabolic process;GO:0006684 sphingomyelin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N6X9-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N724-1", "uniprot_id": [ { "id": "F1N724_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N724", "type": "external" } ], "mass": 537442.0, "length": 4672, "protein_name": "Dynein axonemal heavy chain 11", "gene_name": "DNAH11", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DNAH11", "gene_names_refseq": "", "protein_names_uniprotkb": "Dynein axonemal heavy chain 11; Axonemal beta dynein heavy chain 11; Ciliary dynein heavy chain 11", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Force generating protein required for cilia beating in respiratory epithelia. Produces force towards the minus ends of microtubules. Key component of dynein, a family of motor proteins essential for movement along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of cilia., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005874 microtubule;GO:0005930 axoneme;GO:0030286 dynein complex;GO:0097729 9+2 motile cilium;GO:0097728 9+0 motile cilium", "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0120229 protein localization to motile cilium", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N724-1", "record_type": "protein", "filter_code": "0000000.0000000.000100.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N797-1", "uniprot_id": [ { "id": "F1N797_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N797", "type": "external" } ], "mass": 69392.0, "length": 607, "protein_name": "Membrane-type matrix metalloproteinase 1", "gene_name": "MMP16", "organism": "Bovine", "refseq_name": "matrix metalloproteinase-16", "refseq_ac": [ { "id": "NP_001179551", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179551", "type": "external" } ], "gene_names_uniprotkb": "MMP16", "gene_names_refseq": "MMP16", "protein_names_uniprotkb": "Membrane-type matrix metalloproteinase 1; Membrane-type-1 matrix metalloproteinase", "protein_names_refseq": "matrix metallopeptidase 16 (membrane-inserted); matrix metalloproteinase 16 (membrane-inserted); matrix metalloproteinase-16", "tax_id": 9913, "disease": "", "pathway": " (bta:282886); (R-BTA-1592389); (R-BTA-9839383)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0070006 metalloaminopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0016485 protein processing;GO:0030198 extracellular matrix organization;GO:0001501 skeletal system development;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N797-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N7J2-1", "uniprot_id": [ { "id": "F1N7J2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N7J2", "type": "external" } ], "mass": 134785.0, "length": 1220, "protein_name": "Calcium-transporting ATPase", "gene_name": "ATP2B1", "organism": "Bovine", "refseq_name": "plasma membrane calcium-transporting ATPase 1 isoform X2", "refseq_ac": [ { "id": "XP_024847147", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847147", "type": "external" } ], "gene_names_uniprotkb": "ATP2B1", "gene_names_refseq": "ATP2B1; PMCA", "protein_names_uniprotkb": "Calcium-transporting ATPase; 7.2.2.10", "protein_names_refseq": "plasma membrane calcium-transporting ATPase 1 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-418359); (R-BTA-5578775); (R-BTA-936837)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "30573663", "class_list": "", "function": "Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts. Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells. May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0005388 P-type calcium transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030672 synaptic vesicle membrane;GO:0042734 presynaptic membrane;GO:0098978 glutamatergic synapse;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0051480 regulation of cytosolic calcium ion concentration;GO:1900076 regulation of cellular response to insulin stimulus;GO:0003056 regulation of vascular associated smooth muscle contraction;GO:0008217 regulation of blood pressure;GO:0030501 positive regulation of bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1N7J2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F2Z4F2-1", "uniprot_id": [ { "id": "F2Z4F2_BOVIN", "url": "https://www.uniprot.org/uniprot/F2Z4F2", "type": "external" } ], "mass": 58060.0, "length": 503, "protein_name": "aromatase", "gene_name": "CYP19A1", "organism": "Bovine", "refseq_name": "aromatase isoform X1", "refseq_ac": [ { "id": "XP_059746204", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059746204", "type": "external" } ], "gene_names_uniprotkb": "CYP19A1", "gene_names_refseq": "CYP19A1; CYP19P1; CYP19", "protein_names_uniprotkb": "aromatase; 1.14.14.14; Cytochrome P-450AROM; Estrogen synthase", "protein_names_refseq": "aromatase isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-193144); (R-BTA-211976)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.14", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.14", "type": "external" } ], "go_molecular_function": "GO:0070330 aromatase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0008395 steroid hydroxylase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0006710 androgen catabolic process;GO:2000866 positive regulation of estradiol secretion;GO:0032355 response to estradiol;GO:0006703 estrogen biosynthetic process;GO:0008585 female gonad development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F2Z4F2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F2Z4G3-1", "uniprot_id": [ { "id": "F2Z4G3_BOVIN", "url": "https://www.uniprot.org/uniprot/F2Z4G3", "type": "external" } ], "mass": 46896.0, "length": 420, "protein_name": "Pre-mRNA-splicing factor RBM22", "gene_name": "RBM22", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RBM22", "gene_names_refseq": "", "protein_names_uniprotkb": "Pre-mRNA-splicing factor RBM22; RNA-binding motif protein 22", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-72163)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036002 pre-mRNA binding;GO:0008270 zinc ion binding;GO:0048306 calcium-dependent protein binding;GO:0017070 U6 snRNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0071006 U2-type catalytic step 1 spliceosome;GO:0071007 U2-type catalytic step 2 spliceosome;GO:0000974 Prp19 complex", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0033120 positive regulation of RNA splicing;GO:0046827 positive regulation of protein export from nucleus;GO:0071466 cellular response to xenobiotic stimulus;GO:0045292 mRNA cis splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F2Z4G3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F2Z4H6-1", "uniprot_id": [ { "id": "F2Z4H6_BOVIN", "url": "https://www.uniprot.org/uniprot/F2Z4H6", "type": "external" } ], "mass": 63943.0, "length": 574, "protein_name": "E3 ubiquitin-protein ligase TRIM23", "gene_name": "TRIM23", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase TRIM23", "refseq_ac": [ { "id": "NP_001073772", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073772", "type": "external" } ], "gene_names_uniprotkb": "TRIM23", "gene_names_refseq": "TRIM23", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM23; 2.3.2.27; ADP-ribosylation factor domain-containing protein 1; GTP-binding protein ARD-1; RING-type E3 ubiquitin transferase TRIM23; Tripartite motif-containing protein 23", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM23", "tax_id": 9913, "disease": "", "pathway": " (bta:537285)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0010508 positive regulation of autophagy;GO:0016567 protein ubiquitination;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F2Z4H6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6PSX0-1", "uniprot_id": [ { "id": "F6PSX0_BOVIN", "url": "https://www.uniprot.org/uniprot/F6PSX0", "type": "external" } ], "mass": 33064.0, "length": 300, "protein_name": "Interferon induced protein 35", "gene_name": "IFI35", "organism": "Bovine", "refseq_name": "interferon-induced 35 kDa protein isoform X1", "refseq_ac": [ { "id": "XP_005220767", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220767", "type": "external" } ], "gene_names_uniprotkb": "IFI35", "gene_names_refseq": "IFI35", "protein_names_uniprotkb": "Interferon induced protein 35", "protein_names_refseq": "interferon-induced 35 kDa protein isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0045087 innate immune response;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0050729 positive regulation of inflammatory response;GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6PSX0-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6PV87-1", "uniprot_id": [ { "id": "F6PV87_BOVIN", "url": "https://www.uniprot.org/uniprot/F6PV87", "type": "external" } ], "mass": 46909.0, "length": 424, "protein_name": "Vasopressin V1a receptor", "gene_name": "AVPR1A", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AVPR1A", "gene_names_refseq": "", "protein_names_uniprotkb": "Vasopressin V1a receptor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-388479); (R-BTA-416476)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005000 vasopressin receptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0032870 cellular response to hormone stimulus;GO:0045907 positive regulation of vasoconstriction;GO:0001992 regulation of systemic arterial blood pressure by vasopressin", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6PV87-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6Q077-1", "uniprot_id": [ { "id": "F6Q077_BOVIN", "url": "https://www.uniprot.org/uniprot/F6Q077", "type": "external" } ], "mass": 60970.0, "length": 552, "protein_name": "Crossover junction endonuclease MUS81", "gene_name": "MUS81", "organism": "Bovine", "refseq_name": "structure-specific endonuclease subunit MUS81", "refseq_ac": [ { "id": "NP_001421718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421718", "type": "external" } ], "gene_names_uniprotkb": "MUS81", "gene_names_refseq": "MUS81", "protein_names_uniprotkb": "Crossover junction endonuclease MUS81; 3.1.22.-", "protein_names_refseq": "MUS81 endonuclease homolog; structure-specific endonuclease subunit MUS81", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0008821 crossover junction DNA endonuclease activity;GO:0048257 3'-flap endonuclease activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0001650 fibrillar center;GO:0048476 Holliday junction resolvase complex;GO:0000781 chromosome, telomeric region;GO:0005634 nucleus", "go_biological_process": "GO:0033687 osteoblast proliferation;GO:0000723 telomere maintenance;GO:0006308 DNA catabolic process;GO:0000727 double-strand break repair via break-induced replication;GO:0031297 replication fork processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6Q077-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6QF86-1", "uniprot_id": [ { "id": "F6QF86_BOVIN", "url": "https://www.uniprot.org/uniprot/F6QF86", "type": "external" } ], "mass": 58305.0, "length": 507, "protein_name": "Alpha-1,3-glucosyltransferase", "gene_name": "ALG6", "organism": "Bovine", "refseq_name": "dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase precursor", "refseq_ac": [ { "id": "NP_001068900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068900", "type": "external" } ], "gene_names_uniprotkb": "ALG6", "gene_names_refseq": "ALG6", "protein_names_uniprotkb": "Alpha-1,3-glucosyltransferase; 2.4.1.-", "protein_names_refseq": "asparagine-linked glycosylation 6 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase); asparagine-linked glycosylation 6, alpha-1,3-glucosyltransferase homolog; dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase precursor; dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:510138); (R-BTA-446193)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Man(9)GlcNAc(2)-PP-Dol to produce Glc(1)Man(9)GlcNAc(2)-PP-Dol. Glc(1)Man(9)GlcNAc(2)-PP-Dol is a substrate for ALG8, the following enzyme in the biosynthetic pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0042281 dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process", "synthesized_glycan_count": 150, "hit_score": 0.1, "record_id": "F6QF86-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6QNS8-1", "uniprot_id": [ { "id": "F6QNS8_BOVIN", "url": "https://www.uniprot.org/uniprot/F6QNS8", "type": "external" } ], "mass": 35049.0, "length": 304, "protein_name": "Zinc finger CCCH-type containing 8", "gene_name": "ZC3H8", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ZC3H8", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger CCCH-type containing 8", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-6807505)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0008023 transcription elongation factor complex;GO:0015030 Cajal body;GO:0000791 euchromatin;GO:0035363 histone locus body", "go_biological_process": "GO:0032785 negative regulation of DNA-templated transcription, elongation;GO:0070245 positive regulation of thymocyte apoptotic process;GO:0046677 response to antibiotic;GO:0043029 T cell homeostasis;GO:0045945 positive regulation of transcription by RNA polymerase III", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6QNS8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6QT88-1", "uniprot_id": [ { "id": "F6QT88_BOVIN", "url": "https://www.uniprot.org/uniprot/F6QT88", "type": "external" } ], "mass": 46769.0, "length": 450, "protein_name": "Growth/differentiation factor 7", "gene_name": "GDF7", "organism": "Bovine", "refseq_name": "growth/differentiation factor 7 precursor", "refseq_ac": [ { "id": "NP_001193030", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193030", "type": "external" } ], "gene_names_uniprotkb": "GDF7", "gene_names_refseq": "GDF7", "protein_names_uniprotkb": "Growth/differentiation factor 7", "protein_names_refseq": "growth/differentiation factor 7 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:286859)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play an active role in the motor area of the primate neocortex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0045893 positive regulation of DNA-templated transcription;GO:0030509 BMP signaling pathway;GO:0032924 activin receptor signaling pathway;GO:2001051 positive regulation of tendon cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6QT88-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6R6Q1-1", "uniprot_id": [ { "id": "F6R6Q1_BOVIN", "url": "https://www.uniprot.org/uniprot/F6R6Q1", "type": "external" } ], "mass": 54273.0, "length": 490, "protein_name": "Bifunctional FAD diphosphatase/FAD synthase", "gene_name": "FLAD1", "organism": "Bovine", "refseq_name": "bifunctional FAD diphosphatase/FAD synthase", "refseq_ac": [ { "id": "NP_001030211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030211", "type": "external" } ], "gene_names_uniprotkb": "FLAD1", "gene_names_refseq": "FLAD1", "protein_names_uniprotkb": "Bifunctional FAD diphosphatase/FAD synthase; 2.7.7.2; 3.6.1.18; 3.6.1.22", "protein_names_refseq": "FAD1 flavin adenine dinucleotide synthetase homolog; bifunctional FAD diphosphatase/FAD synthase", "tax_id": 9913, "disease": "", "pathway": " (bta:506682); (R-BTA-196843)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "This enzyme has two activities: FAD diphosphatase activity and FAD synthase activity. FAD diphosphatase acts on FAD and NADH to produce FMN and NMNH(2-), respectively. FAD synthase catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. In addition to its catalytic activities, the protein also facilitates the delivery of FAD to client apo-flavoproteins. The balance between FAD synthesis and hydrolysis may be regulated by redox-sensing cysteine residues. At a much lower rate, FAD synthase catalyzes the reverse pyrophosphorolytic reaction., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.22", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.7.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.2", "type": "external" }, { "id": "3.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.18", "type": "external" } ], "go_molecular_function": "GO:0003919 FMN adenylyltransferase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006747 FAD biosynthetic process;GO:0006771 riboflavin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6R6Q1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6RD87-1", "uniprot_id": [ { "id": "F6RD87_BOVIN", "url": "https://www.uniprot.org/uniprot/F6RD87", "type": "external" } ], "mass": 60854.0, "length": 549, "protein_name": "SRSF protein kinase 3", "gene_name": "SRPK3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SRPK3", "gene_names_refseq": "", "protein_names_uniprotkb": "SRSF protein kinase 3; 2.7.11.1; Muscle-specific serine kinase 1; Serine/arginine-rich protein-specific kinase 3; Serine/threonine-protein kinase 23", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0030154 cell differentiation;GO:0035556 intracellular signal transduction;GO:0007517 muscle organ development;GO:0000245 spliceosomal complex assembly;GO:0060537 muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6RD87-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6RH18-1", "uniprot_id": [ { "id": "F6RH18_BOVIN", "url": "https://www.uniprot.org/uniprot/F6RH18", "type": "external" } ], "mass": 39905.0, "length": 344, "protein_name": "Beta-1,4-galactosyltransferase", "gene_name": "B4GALT4", "organism": "Bovine", "refseq_name": "beta-1,4-galactosyltransferase 4", "refseq_ac": [ { "id": "NP_001033167", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033167", "type": "external" } ], "gene_names_uniprotkb": "B4GALT4", "gene_names_refseq": "B4GALT4", "protein_names_uniprotkb": "Beta-1,4-galactosyltransferase; 2.4.1.-; Beta-1,4-GalTase", "protein_names_refseq": "UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4; beta-1,4-galactosyltransferase 4", "tax_id": 9913, "disease": "", "pathway": " (bta:511328); (R-BTA-2022854); (R-BTA-975577)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" } ], "go_molecular_function": "GO:0008378 galactosyltransferase activity;GO:0046872 metal ion binding;GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity;GO:0003945 N-acetyllactosamine synthase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0018146 keratan sulfate proteoglycan biosynthetic process;GO:0001572 lactosylceramide biosynthetic process", "synthesized_glycan_count": 2205, "hit_score": 0.1, "record_id": "F6RH18-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6RLQ6-1", "uniprot_id": [ { "id": "F6RLQ6_BOVIN", "url": "https://www.uniprot.org/uniprot/F6RLQ6", "type": "external" } ], "mass": 83413.0, "length": 741, "protein_name": "ATP binding cassette subfamily D member 2", "gene_name": "ABCD2", "organism": "Bovine", "refseq_name": "ATP-binding cassette sub-family D member 2 isoform 1", "refseq_ac": [ { "id": "NP_001421923", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421923", "type": "external" } ], "gene_names_uniprotkb": "ABCD2", "gene_names_refseq": "ABCD2", "protein_names_uniprotkb": "ATP binding cassette subfamily D member 2", "protein_names_refseq": "ATP-binding cassette sub-family D member 2 isoform 1; ATP-binding cassette, sub-family D (ALD), member 2; ATP-binding cassette, sub-family D, member 2", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1369062); (R-BTA-9603798)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0042803 protein homodimerization activity;GO:0047617 fatty acyl-CoA hydrolase activity", "go_cellular_component": "GO:0005778 peroxisomal membrane", "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:0006635 fatty acid beta-oxidation;GO:0032000 positive regulation of fatty acid beta-oxidation;GO:0042760 very long-chain fatty acid catabolic process;GO:1990535 neuron projection maintenance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6RLQ6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6RRL6-1", "uniprot_id": [ { "id": "F6RRL6_BOVIN", "url": "https://www.uniprot.org/uniprot/F6RRL6", "type": "external" } ], "mass": 59035.0, "length": 527, "protein_name": "V(D)J recombination-activating protein 2", "gene_name": "RAG2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RAG2", "gene_names_refseq": "", "protein_names_uniprotkb": "V(D)J recombination-activating protein 2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0008270 zinc ion binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0097519 DNA recombinase complex", "go_biological_process": "GO:0002331 pre-B cell allelic exclusion;GO:0033151 V(D)J recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6RRL6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6RTH3-1", "uniprot_id": [ { "id": "F6RTH3_BOVIN", "url": "https://www.uniprot.org/uniprot/F6RTH3", "type": "external" } ], "mass": 16578.0, "length": 147, "protein_name": "Phospholipase A2", "gene_name": "PLA2G2D4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PLA2G2D4", "gene_names_refseq": "", "protein_names_uniprotkb": "Phospholipase A2; 3.1.1.4", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.-.-.-", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0050482 arachidonate secretion;GO:0006644 phospholipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6RTH3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G1K200-1", "uniprot_id": [ { "id": "G1K200_BOVIN", "url": "https://www.uniprot.org/uniprot/G1K200", "type": "external" } ], "mass": 84206.0, "length": 758, "protein_name": "Lysyl oxidase homolog 4", "gene_name": "LOXL4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LOXL4", "gene_names_refseq": "", "protein_names_uniprotkb": "Lysyl oxidase homolog 4; 1.4.3.13; Lysyl oxidase-like protein 4", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1566948); (R-BTA-2243919)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in the formation of covalent cross-linkages, and the stabilization of collagen and elastin fibers., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.13", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" } ], "go_molecular_function": "GO:0005507 copper ion binding;GO:0004720 protein-lysine 6-oxidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0031012 extracellular matrix;GO:0043235 receptor complex", "go_biological_process": "GO:0030199 collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G1K200-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MWX2-1", "uniprot_id": [ { "id": "G3MWX2_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MWX2", "type": "external" } ], "mass": 25741.0, "length": 234, "protein_name": "Acyl-protein thioesterase 1", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Acyl-protein thioesterase 1; 3.1.2.22; Lysophospholipase 1; Lysophospholipase I; Palmitoyl-protein hydrolase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as an acyl-protein thioesterase. Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Acts as a palmitoyl thioesterase that catalyzes depalmitoylation of proteins, such as ADRB2, KCNMA1 and SQSTM1. Acts as a negative regulator of autophagy by mediating palmitoylation of SQSTM1, decreasing affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes. Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS). Has much higher thioesterase activity than lysophospholipase activity. Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, 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"https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" } ], "go_molecular_function": "GO:0008474 palmitoyl-(protein) hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0031965 nuclear membrane", 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"2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0097128 cyclin D1-CDK4 complex", "go_biological_process": "GO:0007165 signal transduction;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3MX00-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MXR4-1", "uniprot_id": [ { "id": "G3MXR4_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MXR4", "type": 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"gene_name": "TSNAX", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TSNAX", "gene_names_refseq": "", "protein_names_uniprotkb": "Translin-associated protein X; Translin-associated factor X", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-426486)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0043565 sequence-specific DNA binding;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0030422 siRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3MY03-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MYH8-1", "uniprot_id": [ { "id": "G3MYH8_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MYH8", "type": "external" } ], "mass": 86949.0, "length": 822, "protein_name": "Innate immunity activator", "gene_name": "INAVA", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "INAVA", "gene_names_refseq": "", "protein_names_uniprotkb": "Innate immunity activator", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:1903409 reactive oxygen species biosynthetic process;GO:0045087 innate immune response;GO:0032755 positive regulation of interleukin-6 production;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3MYH8-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MYH9-1", "uniprot_id": [ { "id": "G3MYH9_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MYH9", "type": "external" } ], "mass": 21417.0, "length": 189, "protein_name": "Uncharacterized protein", "gene_name": "LOC618947", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LOC618947", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-909733); (R-BTA-912694)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3MYH9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MYK6-1", "uniprot_id": [ { "id": "G3MYK6_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MYK6", "type": "external" } ], "mass": 25021.0, "length": 221, "protein_name": "small monomeric GTPase", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "small monomeric GTPase; 3.6.5.2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0030141 secretory granule;GO:0016324 apical plasma membrane;GO:0042470 melanosome;GO:0005770 late endosome", "go_biological_process": "GO:0006887 exocytosis;GO:0045921 positive regulation of exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3MYK6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MYM1-1", "uniprot_id": [ { "id": "G3MYM1_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MYM1", "type": "external" } ], "mass": 222404.0, "length": 1978, "protein_name": "Sodium channel protein", "gene_name": "SCN10A", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SCN10A", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium channel protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient., [UniProtKB, UniProtKB]; Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0044325 transmembrane transporter binding;GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential", "go_cellular_component": "GO:0030424 axon;GO:0001518 voltage-gated sodium channel complex", "go_biological_process": "GO:0019228 neuronal action potential;GO:0019233 sensory perception of pain;GO:0086010 membrane depolarization during action potential;GO:0055117 regulation of cardiac muscle contraction;GO:0035725 sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3MYM1-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MYR8-1", "uniprot_id": [ { "id": "G3MYR8_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MYR8", "type": "external" } ], "mass": 22298.0, "length": 210, "protein_name": "Neurotrophin-4", "gene_name": "NTF4", "organism": "Bovine", "refseq_name": "neurotrophin-4 precursor", "refseq_ac": [ { "id": "NP_001291757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291757", "type": "external" } ], "gene_names_uniprotkb": "NTF4", "gene_names_refseq": "NTF4", "protein_names_uniprotkb": "Neurotrophin-4", "protein_names_refseq": "neurotrophin-4 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:506660); (R-BTA-1257604); (R-BTA-6811558); (R-BTA-9026527); (R-BTA-9028731)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "22460152;22612347", "class_list": "", "function": "Neurotrophin 4 may have a role in regulating the function of bovine oviducts by interacting with gonadotrophins., [RefSeq, PubMed]; This study provided evidence that NT-4 protein was presented in the mature bull spermatozoa and can influence the mitochondrial activity of bovine spermatozoa through TrkB tyrosine kinase-dependent pathways., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0005163 nerve growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0048812 neuron projection morphogenesis;GO:0043524 negative regulation of neuron apoptotic process;GO:0050804 modulation of chemical synaptic transmission;GO:0021675 nerve development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "G3MYR8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MYW0-1", "uniprot_id": [ { "id": "G3MYW0_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MYW0", "type": "external" } ], "mass": 55563.0, "length": 489, "protein_name": "Cytochrome P450 family 2 subfamily F member 1", "gene_name": "CYP2F1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CYP2F1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 family 2 subfamily F member 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-211935); (R-BTA-211981); (R-BTA-211999)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008392 arachidonate epoxygenase activity;GO:0019825 oxygen binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0019373 epoxygenase P450 pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3MYW0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MYX4-1", "uniprot_id": [ { "id": "G3MYX4_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MYX4", "type": "external" } ], "mass": 29444.0, "length": 269, "protein_name": "Homeobox B5", "gene_name": "HOXB5", "organism": "Bovine", "refseq_name": "homeobox protein Hox-B5", "refseq_ac": [ { "id": "XP_024836591", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024836591", "type": "external" } ], "gene_names_uniprotkb": "HOXB5", "gene_names_refseq": "HOXB5", "protein_names_uniprotkb": "Homeobox B5", "protein_names_refseq": "homeobox protein Hox-B5", "tax_id": 9913, "disease": "", "pathway": " (bta:112442653)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3MYX4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MZH3-1", "uniprot_id": [ { "id": "G3MZH3_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MZH3", "type": "external" } ], "mass": 218347.0, "length": 1880, "protein_name": "Unconventional myosin-Va", "gene_name": "MYO5A", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MYO5A", "gene_names_refseq": "", "protein_names_uniprotkb": "Unconventional myosin-Va; Dilute myosin heavy chain, non-muscle", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:541234); (R-BTA-9824585)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Can hydrolyze ATP in the presence of actin, which is essential for its function as a motor protein. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005777 peroxisome;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005884 actin filament", "go_biological_process": "GO:0006892 post-Golgi vesicle-mediated transport;GO:0030050 vesicle transport along actin filament;GO:0030048 actin filament-based movement;GO:0006897 endocytosis;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3MZH3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3MZY1-1", "uniprot_id": [ { "id": "G3MZY1_BOVIN", "url": "https://www.uniprot.org/uniprot/G3MZY1", "type": "external" } ], "mass": 56050.0, "length": 491, "protein_name": "Cytochrome P450", "gene_name": "CYP2C282", "organism": "Bovine", "refseq_name": "cytochrome P450 2C31", "refseq_ac": [ { "id": "XP_024841715", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841715", "type": "external" } ], "gene_names_uniprotkb": "CYP2C282", "gene_names_refseq": "CYP2C282", "protein_names_uniprotkb": "Cytochrome P450; 1.14.14.-", "protein_names_refseq": "cytochrome P450 2C31", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042178 xenobiotic catabolic process;GO:0019373 epoxygenase P450 pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3MZY1-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N083-1", "uniprot_id": [ { "id": "G3N083_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N083", "type": "external" } ], "mass": 39201.0, "length": 357, "protein_name": "Phenylethanolamine N-methyltransferase", "gene_name": "PNMT", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PNMT", "gene_names_refseq": "", "protein_names_uniprotkb": "Phenylethanolamine N-methyltransferase; 2.1.1.28; Noradrenaline N-methyltransferase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-209905)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.28", "type": "external" } ], "go_molecular_function": "GO:0004603 phenylethanolamine N-methyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0032259 methylation;GO:0042423 catecholamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N083-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N0J0-1", "uniprot_id": [ { "id": "G3N0J0_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N0J0", "type": "external" } ], "mass": 53988.0, "length": 470, "protein_name": "Matrix metallopeptidase 8", "gene_name": "MMP8", "organism": "Bovine", "refseq_name": "neutrophil collagenase", "refseq_ac": [ { "id": "XP_024831456", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024831456", "type": "external" } ], "gene_names_uniprotkb": "MMP8", "gene_names_refseq": "MMP8", "protein_names_uniprotkb": "Matrix metallopeptidase 8", "protein_names_refseq": "neutrophil collagenase", "tax_id": 9913, "disease": "", "pathway": " (bta:100336575); (R-BTA-1442490); (R-BTA-1474228); (R-BTA-1592389); (R-BTA-6798695)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008270 zinc ion binding;GO:0043120 tumor necrosis factor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0071222 cellular response to lipopolysaccharide;GO:0032760 positive regulation of tumor necrosis factor production;GO:0030574 collagen catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N0J0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N0J6-1", "uniprot_id": [ { "id": "G3N0J6_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N0J6", "type": "external" } ], "mass": 13241.0, "length": 119, "protein_name": "Small nuclear ribonucleoprotein Sm D1", "gene_name": "SNRPD1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SNRPD1; LOC107131841", "gene_names_refseq": "", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein Sm D1; snRNP core protein D1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005829 cytosol;GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP;GO:0034715 pICln-Sm protein complex", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N0J6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N1Q1-1", "uniprot_id": [ { "id": "G3N1Q1_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N1Q1", "type": "external" } ], "mass": 49932.0, "length": 442, "protein_name": "5-hydroxytryptamine receptor 3B", "gene_name": "HTR3B", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HTR3B", "gene_names_refseq": "", "protein_names_uniprotkb": "5-hydroxytryptamine receptor 3B; Serotonin receptor 3B", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-112314)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0022850 serotonin-gated monoatomic cation channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0005231 excitatory extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0007268 chemical synaptic transmission;GO:0034220 monoatomic ion transmembrane transport;GO:0140227 serotonin-gated cation-selective signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N1Q1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N260-1", "uniprot_id": [ { "id": "G3N260_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N260", "type": "external" } ], "mass": 58494.0, "length": 527, "protein_name": "Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial", "gene_name": "EARS2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "EARS2", "gene_names_refseq": "", "protein_names_uniprotkb": "Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial; 6.1.1.17; 6.1.1.24; Glutamate--tRNA(Gln) ligase EARS2, mitochondrial; Glutamyl-tRNA synthetase; Mitochondrial glutamyl-tRNA synthetase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:100300732)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Non-discriminating glutamyl-tRNA synthetase that catalyzes aminoacylation of both mitochondrial tRNA(Glu) and tRNA(Gln) and participates in RNA aminoacylation for mitochondrial protein translation. Attachs glutamate to tRNA(Glu) or tRNA(Gln) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) or tRNA(Gln). In vitro, cytoplasmic tRNA(Gln) is slightly glutamylated, but with low activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.15", "type": "external" }, { "id": "6.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.17", "type": "external" }, { "id": "6.1.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.24", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0000049 tRNA binding;GO:0004818 glutamate-tRNA ligase activity;GO:0050561 glutamate-tRNA(Gln) ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006424 glutamyl-tRNA aminoacylation;GO:0070127 tRNA aminoacylation for mitochondrial protein translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N260-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N2D2-1", "uniprot_id": [ { "id": "G3N2D2_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N2D2", "type": "external" } ], "mass": 41541.0, "length": 367, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "TSSK1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TSSK1; TSSK1B", "gene_names_refseq": "", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031514 motile cilium", "go_biological_process": "GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N2D2-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N2G9-1", "uniprot_id": [ { "id": "G3N2G9_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N2G9", "type": "external" } ], "mass": 60264.0, "length": 535, "protein_name": "Bactericidal permeability-increasing protein", "gene_name": "LOC514978", "organism": "Bovine", "refseq_name": "lipopolysaccharide-binding protein isoform X2", "refseq_ac": [ { "id": "XP_002692362", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002692362", "type": "external" } ], "gene_names_uniprotkb": "LOC514978", "gene_names_refseq": "LOC514978", "protein_names_uniprotkb": "Bactericidal permeability-increasing protein; BPI", "protein_names_refseq": "lipopolysaccharide-binding protein isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:514978)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0043032 positive regulation of macrophage activation;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0006953 acute-phase response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N2G9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N2J4-1", "uniprot_id": [ { "id": "G3N2J4_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N2J4", "type": "external" } ], "mass": 84888.0, "length": 761, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "TTBK1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TTBK1", "gene_names_refseq": "", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, 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1.14.11.68; JmjC domain-containing protein 3; Jumonji domain-containing protein 3; [histone H3]-trimethyl-L-lysine(27) demethylase 6B", "protein_names_refseq": "lysine-specific demethylase 6B isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:100140276); (R-BTA-2559580); (R-BTA-3214842)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, 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muscle cell differentiation;GO:0010468 regulation of gene expression;GO:0048333 mesodermal cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N346-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N3P0-1", "uniprot_id": [ { "id": "G3N3P0_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N3P0", "type": "external" } ], "mass": 91406.0, "length": 805, "protein_name": "BICD cargo adaptor 2", "gene_name": "BICD2", "organism": "Bovine", "refseq_name": "protein bicaudal D homolog 2", "refseq_ac": [ { "id": "NP_001193404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193404", "type": "external" } ], "gene_names_uniprotkb": "BICD2", "gene_names_refseq": "BICD2", "protein_names_uniprotkb": "BICD cargo adaptor 2", "protein_names_refseq": "protein bicaudal D homolog 2", "tax_id": 9913, "disease": "", "pathway": " (bta:282447); 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"reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008093 cytoskeletal anchor activity;GO:0031267 small GTPase binding;GO:0070840 dynein complex binding;GO:0034452 dynactin binding;GO:0051959 dynein light intermediate chain binding", "go_cellular_component": "GO:0005643 nuclear pore;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0007018 microtubule-based movement;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0034067 protein localization to Golgi apparatus;GO:0051642 centrosome localization;GO:0070507 regulation of microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N3P0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3N3S1-1", "uniprot_id": [ { "id": "G3N3S1_BOVIN", "url": "https://www.uniprot.org/uniprot/G3N3S1", "type": "external" } ], "mass": 32042.0, "length": 305, "protein_name": "GS homeobox 2", "gene_name": "GSX2", "organism": "Bovine", "refseq_name": "GS homeobox 2", "refseq_ac": [ { "id": "NP_001179129", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179129", "type": "external" } ], "gene_names_uniprotkb": "GSX2", "gene_names_refseq": "GSX2", "protein_names_uniprotkb": "GS homeobox 2", "protein_names_refseq": "GS homeobox 2", "tax_id": 9913, "disease": "", "pathway": " (bta:539228)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 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"go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0048699 generation of neurons;GO:0021772 olfactory bulb development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3N3S1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X680-1", "uniprot_id": [ { "id": "G3X680_BOVIN", "url": "https://www.uniprot.org/uniprot/G3X680", "type": "external" } ], "mass": 75752.0, "length": 655, "protein_name": "Tyrosine-protein kinase", "gene_name": "BMX", "organism": "Bovine", "refseq_name": "cytoplasmic tyrosine-protein kinase BMX isoform X1", "refseq_ac": [ { "id": "XP_005228505", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005228505", "type": "external" } ], "gene_names_uniprotkb": "BMX", "gene_names_refseq": "BMX", "protein_names_uniprotkb": "Tyrosine-protein kinase; 2.7.10.2", "protein_names_refseq": "cytoplasmic tyrosine-protein kinase BMX isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-111465); (R-BTA-1660499)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.22.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.56", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" } ], "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032587 ruffle membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0035556 intracellular signal transduction;GO:0006915 apoptotic process;GO:0002250 adaptive immune response;GO:0050853 B cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3X680-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X693-1", "uniprot_id": [ { "id": "G3X693_BOVIN", "url": "https://www.uniprot.org/uniprot/G3X693", "type": "external" } ], "mass": 34800.0, "length": 317, "protein_name": "Ig-like domain-containing protein", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig-like domain-containing protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, 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"type": "external" } ], "mass": 49562.0, "length": 447, "protein_name": "Alpha-2B adrenergic receptor", "gene_name": "ADRA2B", "organism": "Bovine", "refseq_name": "alpha-2B adrenergic receptor", "refseq_ac": [ { "id": "NP_001193557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193557", "type": "external" } ], "gene_names_uniprotkb": "ADRA2B", "gene_names_refseq": "ADRA2B", "protein_names_uniprotkb": "Alpha-2B adrenergic receptor; Alpha-2B adrenoreceptor", "protein_names_refseq": "adrenergic, alpha-2B-, receptor; alpha adrenergic receptor subtype 2B; alpha-2B adrenergic receptor; alpha-2B adrenoceptor; alpha-2B adrenoreceptor; alpha-2BAR", "tax_id": 9913, "disease": "", "pathway": " (bta:516422); (R-BTA-390696); (R-BTA-392023); (R-BTA-418594); (R-BTA-418597)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate G(i/o) protein pathway, 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}, { "uniprot_canonical_ac": "G5E522-1", "uniprot_id": [ { "id": "G5E522_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E522", "type": "external" } ], "mass": 131133.0, "length": 1155, "protein_name": "Transient receptor potential cation channel subfamily A member 1", "gene_name": "TRPA1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TRPA1", "gene_names_refseq": "", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily A member 1; Ankyrin-like with transmembrane domains protein 1; Wasabi receptor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-3295583)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, 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"external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0097604 temperature-gated cation channel activity;GO:0042802 identical protein binding;GO:0015278 intracellularly gated calcium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032421 stereocilium bundle", "go_biological_process": "GO:0071240 cellular response to food;GO:0007166 cell surface receptor signaling pathway;GO:0009409 response to cold;GO:0051289 protein homotetramerization;GO:0006874 intracellular calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E522-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E540-1", "uniprot_id": [ { "id": "G5E540_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E540", "type": "external" } ], "mass": 60480.0, "length": 532, "protein_name": "Flavin-containing monooxygenase", "gene_name": "FMO2", "organism": "Bovine", "refseq_name": "flavin-containing monooxygenase 2 isoform 1", "refseq_ac": [ { "id": "NP_001156746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156746", "type": "external" } ], "gene_names_uniprotkb": "FMO2", "gene_names_refseq": "FMO2", "protein_names_uniprotkb": "Flavin-containing monooxygenase; 1.-.-.-", "protein_names_refseq": "dimethylaniline monooxygenase (N-oxide-forming) 2; dimethylaniline monooxygenase [N-oxide-forming] 2; dimethylaniline oxidase 2; flavin containing monooxygenase 2 (non-functional); flavin-containing monooxygenase 2 isoform 1; pulmonary flavin-containing monooxygenase 2 (Dimethylaniline oxidase 2) (FMO 1B1)", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-217271)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 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"secondary_ac_list": "", "ec_number_list": [ { "id": "1.-.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0050661 NADP binding;GO:0004499 N,N-dimethylaniline monooxygenase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0006805 xenobiotic metabolic process;GO:0009404 toxin metabolic process;GO:0006082 organic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E540-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E5A1-1", "uniprot_id": [ { "id": "G5E5A1_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E5A1", "type": "external" } ], "mass": 161824.0, "length": 1460, "protein_name": "Calmodulin regulated spectrin 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"total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0030507 spectrin binding;GO:0051011 microtubule minus-end binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0036449 microtubule minus-end", "go_biological_process": "GO:0031113 regulation of microtubule polymerization;GO:0007026 negative regulation of microtubule depolymerization;GO:0061564 axon development;GO:0031122 cytoplasmic microtubule organization;GO:0050773 regulation of dendrite development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E5A1-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E5C6-1", "uniprot_id": [ { "id": "G5E5C6_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E5C6", "type": "external" } ], "mass": 45494.0, "length": 414, "protein_name": "Acrosin", "gene_name": "ACR", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ACR", "gene_names_refseq": "", "protein_names_uniprotkb": "Acrosin; 3.4.21.10", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1300645)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.10", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0006508 proteolysis;GO:0007340 acrosome reaction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E5C6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E5G7-1", "uniprot_id": [ { "id": "G5E5G7_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E5G7", "type": "external" } ], "mass": 26296.0, "length": 238, "protein_name": "Tetraspanin", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Tetraspanin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, 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"external" } ], "mass": 43184.0, "length": 392, "protein_name": "exo-alpha-sialidase", "gene_name": "NEU2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NEU2", "gene_names_refseq": "", "protein_names_uniprotkb": "exo-alpha-sialidase; 3.2.1.18", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-4085001); (R-BTA-9840310)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, 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(R-BTA-8957275)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, 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"https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.16.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.4.1.145", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" } ], "go_molecular_function": "GO:0004623 phospholipase A2 activity;GO:0004806 triacylglycerol lipase activity;GO:0050253 retinyl-palmitate esterase activity;GO:0051264 mono-olein transacylation activity;GO:0051265 diolein transacylation activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0010891 negative regulation of triglyceride storage;GO:0010898 positive regulation of triglyceride catabolic process;GO:0055088 lipid homeostasis;GO:0006651 diacylglycerol biosynthetic process;GO:0019433 triglyceride catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E5T0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E5X7-1", "uniprot_id": [ { "id": "G5E5X7_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E5X7", "type": "external" } ], "mass": 69014.0, "length": 624, "protein_name": "Pannexin", "gene_name": "PANX2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PANX2; PANX", "gene_names_refseq": "", "protein_names_uniprotkb": "Pannexin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-112303)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Structural component of the gap junctions and the hemichannels., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, 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monoatomic ion transmembrane transport;GO:0006812 monoatomic cation transport;GO:0032732 positive regulation of interleukin-1 production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E5X7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E626-1", "uniprot_id": [ { "id": "G5E626_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E626", "type": "external" } ], "mass": 164841.0, "length": 1504, "protein_name": "ATP-binding cassette sub-family C member 6", "gene_name": "ABCC6", "organism": "Bovine", "refseq_name": "multidrug resistance-associated protein 6", "refseq_ac": [ { "id": "NP_001263299", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263299", "type": "external" } ], "gene_names_uniprotkb": "ABCC6", "gene_names_refseq": "ABCC6", "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 6; 7.6.2.3; Multidrug resistance-associated 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"7.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0015431 ABC-type glutathione S-conjugate transporter activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0055062 phosphate ion homeostasis;GO:0055074 calcium ion homeostasis;GO:0046034 ATP metabolic process;GO:0010467 gene expression;GO:0015867 ATP transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E626-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E639-1", "uniprot_id": [ { "id": "G5E639_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E639", "type": "external" } ], "mass": 30305.0, "length": 281, "protein_name": "F-box/SPRY domain-containing protein 1", "gene_name": "FBXO45", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FBXO45", "gene_names_refseq": "", "protein_names_uniprotkb": "F-box/SPRY domain-containing protein 1; F-box only protein 45", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0014069 postsynaptic density;GO:0045202 synapse;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0006974 DNA damage response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination;GO:2000300 regulation of synaptic vesicle exocytosis;GO:0060386 synapse assembly involved in innervation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E639-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E666-1", "uniprot_id": [ { "id": "G5E666_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E666", "type": "external" } ], "mass": 23083.0, "length": 201, "protein_name": "GOLD domain-containing protein", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "GOLD domain-containing protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1912420); (R-BTA-204005); (R-BTA-5694530); (R-BTA-6807878); (R-BTA-6811434)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E666-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E6E7-1", "uniprot_id": [ { "id": "G5E6E7_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E6E7", "type": "external" } ], "mass": 8472.0, "length": 76, "protein_name": "Small nuclear ribonucleoprotein G", "gene_name": "LOC107132556", "organism": "Bovine", "refseq_name": "small nuclear ribonucleoprotein G-like", "refseq_ac": [ { "id": "XP_059743869", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059743869", "type": "external" } ], "gene_names_uniprotkb": "LOC107132556", "gene_names_refseq": "LOC107132556", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein G; snRNP-G", "protein_names_refseq": "small nuclear ribonucleoprotein G-like", "tax_id": 9913, "disease": "", "pathway": " (bta:107132556)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005829 cytosol;GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP;GO:0071011 precatalytic spliceosome", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E6E7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E6I1-1", "uniprot_id": [ { "id": "G5E6I1_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E6I1", "type": "external" } ], "mass": 37375.0, "length": 333, "protein_name": "T-cell surface glycoprotein CD1b-1-like", "gene_name": "CD1B5", "organism": "Bovine", "refseq_name": "CD1b molecule-like precursor", "refseq_ac": [ { "id": "NP_001180226", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180226", "type": "external" } ], "gene_names_uniprotkb": "CD1B5", "gene_names_refseq": "CD1B5", "protein_names_uniprotkb": "T-cell surface glycoprotein CD1b-1-like", "protein_names_refseq": "CD1B5 antigen; CD1b molecule-like precursor; CD1b molecule-like protein", "tax_id": 9913, "disease": "", "pathway": " (bta:521663); (R-BTA-198933)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030883 endogenous lipid antigen binding;GO:0030884 exogenous lipid antigen binding;GO:0071723 lipopeptide binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005765 lysosomal membrane;GO:0009897 external side of plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response;GO:0001916 positive regulation of T cell mediated cytotoxicity;GO:0048007 antigen processing and presentation, exogenous lipid antigen via MHC class Ib;GO:0048006 antigen processing and presentation, endogenous lipid antigen via MHC class Ib", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E6I1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E6J5-1", "uniprot_id": [ { "id": "G5E6J5_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E6J5", "type": "external" } ], "mass": 49307.0, "length": 446, "protein_name": "Tubulin alpha chain", "gene_name": "TUBAL3", "organism": "Bovine", "refseq_name": "tubulin alpha chain-like 3", "refseq_ac": [ { "id": "NP_001422069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422069", "type": "external" } ], "gene_names_uniprotkb": "TUBAL3", "gene_names_refseq": "TUBAL3", "protein_names_uniprotkb": "Tubulin alpha chain", "protein_names_refseq": "tubulin alpha chain-like 3", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2132295); (R-BTA-2467813); (R-BTA-2500257); (R-BTA-3371497); (R-BTA-6807878); (R-BTA-6811436); (R-BTA-9646399); (R-BTA-9648025)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E6J5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G5E6S8-1", "uniprot_id": [ { "id": "G5E6S8_BOVIN", "url": "https://www.uniprot.org/uniprot/G5E6S8", "type": "external" } ], "mass": 35183.0, "length": 326, "protein_name": "Pancreas transcription factor 1 subunit alpha", "gene_name": "PTF1A", "organism": "Bovine", "refseq_name": "pancreas transcription factor 1 subunit alpha", "refseq_ac": [ { "id": "XP_002707767", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002707767", "type": "external" } ], "gene_names_uniprotkb": "PTF1A", "gene_names_refseq": "PTF1A", "protein_names_uniprotkb": "Pancreas transcription factor 1 subunit alpha; Pancreas-specific transcription factor 1a", "protein_names_refseq": "pancreas transcription factor 1 subunit alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:781540)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005667 transcription regulator complex", "go_biological_process": "GO:0061074 regulation of neural retina development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0032502 developmental process;GO:0048384 retinoic acid receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G5E6S8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G8JKX1-1", "uniprot_id": [ { "id": "G8JKX1_BOVIN", "url": "https://www.uniprot.org/uniprot/G8JKX1", "type": "external" } ], "mass": 93758.0, "length": 874, "protein_name": "A disintegrin and metalloproteinase with thrombospondin motifs 4", "gene_name": "ADAMTS4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ADAMTS4", "gene_names_refseq": "", "protein_names_uniprotkb": "A disintegrin and metalloproteinase with thrombospondin motifs 4; 3.4.24.82; Aggrecanase-1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1474228); (R-BTA-5173214)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.221", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.221", "type": "external" }, { "id": "3.4.24.82", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.82", "type": "external" }, { "id": "3.4.24.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.14", "type": "external" } ], "go_molecular_function": "GO:0002020 protease binding;GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016607 nuclear speck;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030167 proteoglycan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G8JKX1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "J9JH84-1", "uniprot_id": [ { "id": "J9JH84_BOVIN", "url": "https://www.uniprot.org/uniprot/J9JH84", "type": "external" } ], "mass": 77326.0, "length": 708, "protein_name": "E3 ubiquitin-protein ligase RNF169", "gene_name": "RNF169", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase RNF169", "refseq_ac": [ { "id": "NP_001422143", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422143", "type": "external" } ], "gene_names_uniprotkb": "RNF169", "gene_names_refseq": "RNF169", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF169; 2.3.2.27; RING finger protein 169; RING-type E3 ubiquitin transferase RNF169", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF169; RING-type E3 ubiquitin transferase RNF169", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization. Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0061649 ubiquitin-modified histone reader activity;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016604 nuclear body;GO:0035861 site of double-strand break", "go_biological_process": "GO:2000780 negative regulation of double-strand break repair;GO:0006302 double-strand break repair;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "J9JH84-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O02739-1", "uniprot_id": [ { "id": "SPB6_BOVIN", "url": "https://www.uniprot.org/uniprot/O02739", "type": "external" } ], "mass": 42561.0, "length": 378, "protein_name": "Serpin B6", "gene_name": "SERPINB6", "organism": "Bovine", "refseq_name": "serpin B6", "refseq_ac": [ { "id": "NP_777214", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777214", "type": "external" } ], "gene_names_uniprotkb": "SERPINB6", "gene_names_refseq": "SERPINB6", "protein_names_uniprotkb": "Serpin B6; Proteinase inhibitor 6; Serine proteinase inhibitor B-43", "protein_names_refseq": "proteinase inhibitor 6; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6; serine proteinase inhibitor B-43; serpin B6", "tax_id": 9913, "disease": "", "pathway": " (bta:286854)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9013786", "class_list": "", "function": "Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress (By similarity). May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PK82", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O02739-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O02751-1", "uniprot_id": [ { "id": "CFDP2_BOVIN", "url": "https://www.uniprot.org/uniprot/O02751", "type": "external" } ], "mass": 66325.0, "length": 592, "protein_name": "Protein CFDP2", "gene_name": "CFDP2", "organism": "Bovine", "refseq_name": "protein CFDP2", "refseq_ac": [ { "id": "NP_777225", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777225", "type": "external" } ], "gene_names_uniprotkb": "CFDP2; BCNT", "gene_names_refseq": "CFDP2; p97Bcnt", "protein_names_uniprotkb": "Protein CFDP2; Craniofacial development protein 2; p97 bucentaur protein", "protein_names_refseq": "bucentaur; p97 bucentaur protein; protein CFDP2", "tax_id": 9913, "disease": "", "pathway": " (bta:286876)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10350657;12832649;9006920;9602175", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O02752;O18732;Q7JFY0;Q8I032", "ec_number_list": [], "go_molecular_function": "GO:0003824 catalytic activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O02751-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O02769-1", "uniprot_id": [ { "id": "MTR1A_BOVIN", "url": "https://www.uniprot.org/uniprot/O02769", "type": "external" } ], "mass": 29370.0, "length": 257, "protein_name": "Melatonin receptor type 1A", "gene_name": "MTNR1A", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MTNR1A", "gene_names_refseq": "", "protein_names_uniprotkb": "Melatonin receptor type 1A; Mel-1A-R; Mel1a receptor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9107687", "class_list": "", "function": "High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Possibly involved in sleep induction, by melatonin activation of the potassium channel KCNMA1/BK and the dissociation of G-beta and G-gamma subunits, thereby decreasing synaptic transmission (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008502 melatonin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O02769-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O18728-1", "uniprot_id": [ { "id": "FSCN2_BOVIN", "url": "https://www.uniprot.org/uniprot/O18728", "type": "external" } ], "mass": 55073.0, "length": 492, "protein_name": "Fascin-2", "gene_name": "FSCN2", "organism": "Bovine", "refseq_name": "fascin-2", "refseq_ac": [ { "id": "NP_788806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788806", "type": "external" } ], "gene_names_uniprotkb": "FSCN2", "gene_names_refseq": "FSCN2", "protein_names_uniprotkb": "Fascin-2; Retinal fascin", "protein_names_refseq": "fascin 2, retinal; fascin homolog 2, actin-bundling protein, retinal; fascin-2; retinal fascin", "tax_id": 9913, "disease": "", "pathway": " (bta:337926)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9315724", "class_list": "", "function": "Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0030674 protein-macromolecule adaptor activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0032420 stereocilium", "go_biological_process": "GO:0016477 cell migration;GO:0030036 actin cytoskeleton organization;GO:0051017 actin filament bundle assembly;GO:0007163 establishment or maintenance of cell polarity;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O18728-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O18739-1", "uniprot_id": [ { "id": "CCN2_BOVIN", "url": "https://www.uniprot.org/uniprot/O18739", "type": "external" } ], "mass": 37924.0, "length": 349, "protein_name": "CCN family member 2", "gene_name": "CCN2", "organism": "Bovine", "refseq_name": "CCN family member 2 precursor", "refseq_ac": [ { "id": "NP_776455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776455", "type": "external" } ], "gene_names_uniprotkb": "CCN2; CTGF", "gene_names_refseq": "CCN2; CTGF", "protein_names_uniprotkb": "CCN family member 2; Cellular communication network factor 2; Connective tissue growth factor", "protein_names_refseq": "CCN family member 2 precursor; CCN family member 2; connective tissue growth factor", "tax_id": 9913, "disease": "", "pathway": " (bta:281103)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15313168;15560785;27185102;30358017;33002529", "class_list": "", "function": "Actin cytoskeleton-dependent regulation of CTGF transcription and mRNA stability, [RefSeq, PubMed]; Bovine CCN2 exhibits unique expression patterns during preimplantation development, and is required for the proper expression of key regulatory genes in bovine blastocysts., [RefSeq, PubMed]; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Is involved in the stimulation of osteoblast differentiation and has a critical role in osteogenesis (By similarity). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity)., [UniProtKB, UniProtKB]; Regulation of the early growth response-1 binding protein NAB2 in bovine granulosa cells and effect on connective tissue growth factor expression., [RefSeq, PubMed]; Results confirm the prodevelopmental actions of activin A and indicate that CTGF may also function as an embryokine by regulating the number of ICM cells in the blastocyst and altering gene expression. Low concentrations of HGF were inhibitory to development., [RefSeq, PubMed]; The results indicate that CTGF suppresses the synthesis of biglycan but newly induced that of decorin in the cells when the cell density is low., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2HJ71;Q9GL71", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0046330 positive regulation of JNK cascade;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O18739-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O18789-1", "uniprot_id": [ { "id": "RS2_BOVIN", "url": "https://www.uniprot.org/uniprot/O18789", "type": "external" } ], "mass": 31235.0, "length": 293, "protein_name": "Small ribosomal subunit protein uS5", "gene_name": "RPS2", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein uS5", "refseq_ac": [ { "id": "NP_001028785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028785", "type": "external" } ], "gene_names_uniprotkb": "RPS2", "gene_names_refseq": "RPS2E; RPS2", "protein_names_uniprotkb": "Small ribosomal subunit protein uS5; 40S ribosomal protein S2", "protein_names_refseq": "40S ribosomal protein S2; ribosomal protein S2e; small ribosomal subunit protein uS5", "tax_id": 9913, "disease": "", "pathway": " (bta:286867)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (By similarity). Plays a role in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2V9C7;Q3T0W5", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0022627 cytosolic small ribosomal subunit;GO:0015935 small ribosomal subunit", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O18789-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O18815-1", "uniprot_id": [ { "id": "DFBC7_BOVIN", "url": "https://www.uniprot.org/uniprot/O18815", "type": "external" } ], "mass": 5650.0, "length": 53, "protein_name": "Beta-defensin C7", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-defensin C7; BBD(C7)", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9488394", "class_list": "", "function": "Has bactericidal activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O18815-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O18875-1", "uniprot_id": [ { "id": "SC6A8_BOVIN", "url": "https://www.uniprot.org/uniprot/O18875", "type": "external" } ], "mass": 70676.0, "length": 635, "protein_name": "Sodium- and chloride-dependent creatine transporter 1", "gene_name": "SLC6A8", "organism": "Bovine", "refseq_name": "sodium- and chloride-dependent creatine transporter 1", "refseq_ac": [ { "id": "NP_777036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777036", "type": "external" } ], "gene_names_uniprotkb": "SLC6A8", "gene_names_refseq": "SLC6A8", "protein_names_uniprotkb": "Sodium- and chloride-dependent creatine transporter 1; CT1; Creatine transporter 1; Solute carrier family 6 member 8", "protein_names_refseq": "CT1; choline transporter; creatine transporter 1; sodium- and chloride-dependent creatine transporter 1; solute carrier family 6 (neurotransmitter transporter, creatine), member 8", "tax_id": 9913, "disease": "", "pathway": " (bta:282367); (R-BTA-71288)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16466692;17982255;27978525", "class_list": "", "function": "Creatine:sodium symporter which mediates the uptake of creatine (By similarity). Plays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; GSK3ss down-regulates the creatine transporter CreaT, an effect reversed by treatment with the antidepressant Lithium and by co-expression of PKB/Akt., [RefSeq, PubMed]; Mammalian target of rapamycin (mTOR) stimulates the creatine transporter SLC6A8 through mechanisms at least partially shared by the serum and glucocorticoid-inducible kinase SGK1., [RefSeq, PubMed]; The observations suggest that SGK1 regulates the creatine transporter SLC6A8 at least partially through phosphorylation and activation of PIKfyve., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005332 gamma-aminobutyric acid:sodium:chloride symporter activity;GO:0005309 creatine:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0006865 amino acid transport;GO:0035725 sodium ion transmembrane transport;GO:0015881 creatine transmembrane transport;GO:0006836 neurotransmitter transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O18875-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O18883-1", "uniprot_id": [ { "id": "TXND9_BOVIN", "url": "https://www.uniprot.org/uniprot/O18883", "type": "external" } ], "mass": 26504.0, "length": 226, "protein_name": "Thioredoxin domain-containing protein 9", "gene_name": "TXNDC9", "organism": "Bovine", "refseq_name": "thioredoxin domain-containing protein 9", "refseq_ac": [ { "id": "NP_001069617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069617", "type": "external" } ], "gene_names_uniprotkb": "TXNDC9; APACD", "gene_names_refseq": "TXNDC9", "protein_names_uniprotkb": "Thioredoxin domain-containing protein 9; Protein 1-4", "protein_names_refseq": "ATP binding protein; protein 1-4; thioredoxin domain-containing protein 9", "tax_id": 9913, "disease": "", "pathway": " (bta:539143)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q17QD0", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0030496 midbody", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O18883-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O18920-1", "uniprot_id": [ { "id": "ANGP1_BOVIN", "url": "https://www.uniprot.org/uniprot/O18920", "type": "external" } ], "mass": 57429.0, "length": 497, "protein_name": "Angiopoietin-1", "gene_name": "ANGPT1", "organism": "Bovine", "refseq_name": "angiopoietin-1 precursor", "refseq_ac": [ { "id": "NP_001070265", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070265", "type": "external" } ], "gene_names_uniprotkb": "ANGPT1; ANG1", "gene_names_refseq": "ANGPT1", "protein_names_uniprotkb": "Angiopoietin-1; ANG-1", "protein_names_refseq": "ANG-1; angiopoietin-1 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:282140); (R-BTA-210993); (R-BTA-5673001)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "15329480;19564638;27216150;9776732;9840613", "class_list": "", "function": "ANPT-1 becomes predominant in the follicle producing high levels of E(2), indicating the possible switch-over from ANPT-2 (antagonist) to ANPT-1 (agonist)., [RefSeq, PubMed]; Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells. Erratum:[Stem Cell Res Ther. 2019 Jan 31;10(1):49. doi: 10.1186/s13287-019-1150-z. PMID: 30704506] Publication Status: Online-Only, [RefSeq, PubMed]; Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development (By similarity)., [UniProtKB]; Inhibition of NO production by Ang-1, via phosphorylation of eNOS on Thr(497) by PKC zeta, is responsible, at least in part, for inhibition of VEGF-stimulated endothelial permeability by Ang-1., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q08DP8", "ec_number_list": [], "go_molecular_function": "GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0001525 angiogenesis;GO:0030154 cell differentiation;GO:0043066 negative regulation of apoptotic process;GO:0007596 blood coagulation;GO:0048014 Tie signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O18920-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O18951-1", "uniprot_id": [ { "id": "P2RY2_BOVIN", "url": "https://www.uniprot.org/uniprot/O18951", "type": "external" } ], "mass": 15006.0, "length": 133, "protein_name": "P2Y purinoceptor 2", "gene_name": "P2RY2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "P2RY2", "gene_names_refseq": "", "protein_names_uniprotkb": "P2Y purinoceptor 2; P2Y2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for ATP and UTP coupled to G proteins that activate a phosphatidylinositol-calcium second messenger system., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031686 A1 adenosine receptor binding;GO:0045030 G protein-coupled UTP receptor activity;GO:0045028 G protein-coupled purinergic nucleotide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0097746 blood vessel diameter maintenance;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0070257 positive regulation of mucus secretion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O18951-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O18968-1", "uniprot_id": [ { "id": "CXB1_BOVIN", "url": "https://www.uniprot.org/uniprot/O18968", "type": "external" } ], "mass": 32083.0, "length": 284, "protein_name": "Gap junction beta-1 protein", "gene_name": "GJB1", "organism": "Bovine", "refseq_name": "gap junction beta-1 protein", "refseq_ac": [ { "id": "NP_776494", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776494", "type": "external" } ], "gene_names_uniprotkb": "GJB1; CXN-32", "gene_names_refseq": "CXNG; GJB1", "protein_names_uniprotkb": "Gap junction beta-1 protein; Connexin-32; Cx32", "protein_names_refseq": "connexin 32; connexin G; cx32; gap junction beta-1 protein; gap junction protein, beta 1, 32 kD; gap junction protein, beta 1, 32kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:281194); (R-BTA-190704)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16310041;8678997", "class_list": "", "function": "Intermediate invasive status of bovine trophoblast is supported by the fact that trophoblast giant cells coexpress connexins (Cx)26, Cx32, and Cx43, [RefSeq, PubMed]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0015868 purine ribonucleotide transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O18968-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O46375-1", "uniprot_id": [ { "id": "TTHY_BOVIN", "url": "https://www.uniprot.org/uniprot/O46375", "type": "external" } ], "mass": 15727.0, "length": 147, "protein_name": "Transthyretin", "gene_name": "TTR", "organism": "Bovine", "refseq_name": "transthyretin precursor", "refseq_ac": [ { "id": "NP_776392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776392", "type": "external" } ], "gene_names_uniprotkb": "TTR", "gene_names_refseq": "TTR", "protein_names_uniprotkb": "Transthyretin; Prealbumin", "protein_names_refseq": "prealbumin; transthyretin (prealbumin, amyloidosis type I); transthyretin precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:280948); (R-BTA-2453902); (R-BTA-6798695); (R-BTA-975634)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "2598638", "class_list": "", "function": "Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZ91", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005179 hormone activity;GO:0140313 molecular sequestering activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0006144 purine nucleobase metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O46375-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O46404-1", "uniprot_id": [ { "id": "P55G_BOVIN", "url": "https://www.uniprot.org/uniprot/O46404", "type": "external" } ], "mass": 54388.0, "length": 461, "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit gamma", "gene_name": "PIK3R3", "organism": "Bovine", "refseq_name": "phosphatidylinositol 3-kinase regulatory subunit gamma", "refseq_ac": [ { "id": "NP_777221", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777221", "type": "external" } ], "gene_names_uniprotkb": "PIK3R3", "gene_names_refseq": "PIK3R3; p55PIK", "protein_names_uniprotkb": "Phosphatidylinositol 3-kinase regulatory subunit gamma; PI3-kinase regulatory subunit gamma; PI3-kinase subunit p85-gamma; PI3K regulatory subunit gamma; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit gamma; PtdIns-3-kinase regulatory subunit gamma; PtdIns-3-kinase regulatory subunit p85-gamma; p55PIK", "protein_names_refseq": "PI3-kinase p85 subunit gamma; PI3-kinase regulatory subunit gamma; PI3-kinase subunit p85-gamma; PI3K regulatory subunit gamma; phosphatidylinositol 3-kinase 85 kDa regulatory subunit gamma; phosphatidylinositol 3-kinase regulatory subunit gamma; phosphoinositide-3-kinase, regulatory subunit 3 (gamma); phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma); phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma); ptdIns-3-kinase p85-gamma; ptdIns-3-kinase regulatory subunit gamma; ptdIns-3-kinase regulatory subunit p85-gamma", "tax_id": 9913, "disease": "", "pathway": " (bta:286865)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046935 1-phosphatidylinositol-3-kinase regulator activity", "go_cellular_component": "GO:0005943 phosphatidylinositol 3-kinase complex, class IA", "go_biological_process": "GO:0008286 insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O46404-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O46471-1", "uniprot_id": [ { "id": "RGS16_BOVIN", "url": "https://www.uniprot.org/uniprot/O46471", "type": "external" } ], "mass": 22636.0, "length": 202, "protein_name": "Regulator of G protein signaling 16", "gene_name": "RGS16", "organism": "Bovine", "refseq_name": "regulator of G-protein signaling 16", "refseq_ac": [ { "id": "NP_776875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776875", "type": "external" } ], "gene_names_uniprotkb": "RGS16", "gene_names_refseq": "RGS16", "protein_names_uniprotkb": "Regulator of G protein signaling 16; RGS-r; RGS16; Retinal-specific RGS; Retinally abundant regulator of G protein signaling", "protein_names_refseq": "RGS-R; regulator of G-protein signaling 16; regulator of G-protein signalling 16; retinal-specific RGS; retinally abundant regulator of G-protein signaling", "tax_id": 9913, "disease": "", "pathway": " (bta:282035); (R-BTA-416476); (R-BTA-418594); (R-BTA-418597)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "9459445", "class_list": "", "function": "Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08E37", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0043547 positive regulation of GTPase activity;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O46471-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O46504-1", "uniprot_id": [ { "id": "PDPR_BOVIN", "url": "https://www.uniprot.org/uniprot/O46504", "type": "external" } ], "mass": 98857.0, "length": 878, "protein_name": "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial", "gene_name": "PDPR", "organism": "Bovine", "refseq_name": "pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial precursor", "refseq_ac": [ { "id": "NP_777206", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777206", "type": "external" } ], "gene_names_uniprotkb": "PDPR", "gene_names_refseq": "PDPR", "protein_names_uniprotkb": "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial; PDPr", "protein_names_refseq": "pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial precursor; pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:286844)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "8643510;9395502", "class_list": "", "function": "Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045254 pyruvate dehydrogenase complex;GO:0019910 mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O46504-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O46685-1", "uniprot_id": [ { "id": "GPR68_BOVIN", "url": "https://www.uniprot.org/uniprot/O46685", "type": "external" } ], "mass": 40906.0, "length": 361, "protein_name": "G protein-coupled receptor 68", "gene_name": "GPR68", "organism": "Bovine", "refseq_name": "G-protein coupled receptor 68", "refseq_ac": [ { "id": "NP_776754", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776754", "type": "external" } ], "gene_names_uniprotkb": "GPR68", "gene_names_refseq": "GPR68", "protein_names_uniprotkb": "G protein-coupled receptor 68; G protein-coupled receptor RGR1; bRGR1", "protein_names_refseq": "G-protein coupled receptor 68; bRGR1; g protein-coupled receptor RGR1; ovarian cancer G-protein coupled receptor 1", "tax_id": 9913, "disease": "", "pathway": " (bta:281799); (R-BTA-373076); (R-BTA-416476)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "9299461", "class_list": "", "function": "Proton-sensing G protein-coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions (By similarity). The receptor is almost silent at pH 7.8 but fully activated at pH 6.8 (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (By similarity). GPR68 is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (By similarity). Acts as a key mechanosensor of fluid shear stress and membrane stretch (By similarity). Expressed in endothelial cells of small-diameter resistance arteries, where it mediates flow-induced dilation in response to shear stress (By similarity). May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone (By similarity). Acts as a regulator of calcium-sensing receptor CASR in a seesaw manner: GPR68-mediated signaling inhibits CASR signaling in response to protons, while CASR inhibits GPR68 in presence of extracellular calcium (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0034405 response to fluid shear stress;GO:0071467 cellular response to pH;GO:0071468 cellular response to acidic pH", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O46685-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O62702-1", "uniprot_id": [ { "id": "KERA_BOVIN", "url": "https://www.uniprot.org/uniprot/O62702", "type": "external" } ], "mass": 40406.0, "length": 352, "protein_name": "Keratocan", "gene_name": "KERA", "organism": "Bovine", "refseq_name": "keratocan precursor", "refseq_ac": [ { "id": "NP_776335", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776335", "type": "external" } ], "gene_names_uniprotkb": "KERA", "gene_names_refseq": "KERA", "protein_names_uniprotkb": "Keratocan; Corneal keratan sulfate proteoglycan 37A core protein; KSPG keratocan; KTN; Keratan sulfate proteoglycan keratocan", "protein_names_refseq": "KSPG keratocan; KTN; corneal keratan sulfate proteoglycan 37A core protein; keratan sulfate proteoglycan keratocan; keratocan precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:280785)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1907274;8621655;9751803", "class_list": "", "function": "May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q0VC34;Q28032", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O62702-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O62703-1", "uniprot_id": [ { "id": "CTBL1_BOVIN", "url": "https://www.uniprot.org/uniprot/O62703", "type": "external" } ], "mass": 65184.0, "length": 563, "protein_name": "Beta-catenin-like protein 1", "gene_name": "CTNNBL1", "organism": "Bovine", "refseq_name": "beta-catenin-like protein 1", "refseq_ac": [ { "id": "NP_777062", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777062", "type": "external" } ], "gene_names_uniprotkb": "CTNNBL1", "gene_names_refseq": "CTNNBL1", "protein_names_uniprotkb": "Beta-catenin-like protein 1; NAP; Nuclear-associated protein; p14", "protein_names_refseq": "NAP; beta-catenin-like protein 1; nuclear-associated protein; p14", "tax_id": 9913, "disease": "", "pathway": " (bta:282421)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated somatic hypermutation (SHM) and class-switch recombination (CSR), 2 processes resulting in the production of high-affinity, mutated isotype-switched antibodies., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2KI34", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005681 spliceosomal complex;GO:0000974 Prp19 complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0002250 adaptive immune response;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O62703-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O62836-1", "uniprot_id": [ { "id": "ZFX_BOVIN", "url": "https://www.uniprot.org/uniprot/O62836", "type": "external" } ], "mass": 90175.0, "length": 800, "protein_name": "Zinc finger X-chromosomal protein", "gene_name": "ZFX", "organism": "Bovine", "refseq_name": "zinc finger X-chromosomal protein", "refseq_ac": [ { "id": "NP_803456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803456", "type": "external" } ], "gene_names_uniprotkb": "ZFX", "gene_names_refseq": "ZFX", "protein_names_uniprotkb": "Zinc finger X-chromosomal protein", "protein_names_refseq": "X-linked zinc finger protein; zinc finger X-chromosomal protein", "tax_id": 9913, "disease": "", "pathway": " (bta:280961)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12356942;9457673", "class_list": "", "function": "Probable transcriptional activator., [UniProtKB, UniProtKB]; ZFX transcripts were noted in all pre-compaction stage embryos and in female and male blastocysts; the expression of ZFX was significantly higher in female than in male blastocysts, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95LI4", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O62836-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77480-1", "uniprot_id": [ { "id": "FMT_BOVIN", "url": "https://www.uniprot.org/uniprot/O77480", "type": "external" } ], "mass": 43620.0, "length": 390, "protein_name": "Methionyl-tRNA formyltransferase, mitochondrial", "gene_name": "MTFMT", "organism": "Bovine", "refseq_name": "methionyl-tRNA formyltransferase, mitochondrial", "refseq_ac": [ { "id": "NP_001159995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159995", "type": "external" } ], "gene_names_uniprotkb": "MTFMT; FMT", "gene_names_refseq": "MTFMT", "protein_names_uniprotkb": "Methionyl-tRNA formyltransferase, mitochondrial; 2.1.2.9; MtFMT", "protein_names_refseq": "methionyl-tRNA formyltransferase, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:286855)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9614118", "class_list": "", "function": "Methionyl-tRNA formyltransferase that formylates methionyl-tRNA in mitochondria and is crucial for translation initiation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.2.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.9", "type": "external" } ], "go_molecular_function": "GO:0004479 methionyl-tRNA formyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0071951 conversion of methionyl-tRNA to N-formyl-methionyl-tRNA", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O77480-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77482-1", "uniprot_id": [ { "id": "IL1RA_BOVIN", "url": "https://www.uniprot.org/uniprot/O77482", "type": "external" } ], "mass": 19926.0, "length": 174, "protein_name": "Interleukin-1 receptor antagonist protein", "gene_name": "IL1RN", "organism": "Bovine", "refseq_name": "interleukin-1 receptor antagonist protein precursor", "refseq_ac": [ { "id": "NP_776782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776782", "type": "external" } ], "gene_names_uniprotkb": "IL1RN", "gene_names_refseq": "IL1RN", "protein_names_uniprotkb": "Interleukin-1 receptor antagonist protein; IL-1RN; IL-1ra; IL1 inhibitor; IRAP", "protein_names_refseq": "IL-1RN; IL-1ra; IL1 inhibitor; IRAP; interleukin-1 receptor antagonist protein precursor; interleukin-1 receptor antagonist protein", "tax_id": 9913, "disease": "", "pathway": " (bta:281860); (R-BTA-9020702)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9643454", "class_list": "", "function": "Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005152 interleukin-1 receptor antagonist activity;GO:0005125 cytokine activity;GO:0005149 interleukin-1 receptor binding;GO:0005150 interleukin-1, type I receptor binding;GO:0045352 interleukin-1 type I receptor antagonist activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0031982 vesicle", "go_biological_process": "GO:2000660 negative regulation of interleukin-1-mediated signaling pathway;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0051384 response to glucocorticoid;GO:0034115 negative regulation of heterotypic cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O77482-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77588-1", "uniprot_id": [ { "id": "PLOD1_BOVIN", "url": "https://www.uniprot.org/uniprot/O77588", "type": "external" } ], "mass": 83487.0, "length": 726, "protein_name": "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1", "gene_name": "PLOD1", "organism": "Bovine", "refseq_name": "procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 precursor", "refseq_ac": [ { "id": "NP_776573", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776573", "type": "external" } ], "gene_names_uniprotkb": "PLOD1; PLOD", "gene_names_refseq": "PLOD1; PLOD", "protein_names_uniprotkb": "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; 1.14.11.4; LH1; Lysyl hydroxylase 1", "protein_names_refseq": "LH1; lysyl hydroxylase 1; procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281409)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (By similarity). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q1JPK0", "ec_number_list": [ { "id": "1.14.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.4", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0008475 procollagen-lysine 5-dioxygenase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0031012 extracellular matrix;GO:0030867 rough endoplasmic reticulum membrane", "go_biological_process": "GO:0030199 collagen fibril organization;GO:0032964 collagen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O77588-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77689-1", "uniprot_id": [ { "id": "CCNB2_BOVIN", "url": "https://www.uniprot.org/uniprot/O77689", "type": "external" } ], "mass": 45260.0, "length": 398, "protein_name": "G2/mitotic-specific cyclin-B2", "gene_name": "CCNB2", "organism": "Bovine", "refseq_name": "G2/mitotic-specific cyclin-B2", "refseq_ac": [ { "id": "NP_776689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776689", "type": "external" } ], "gene_names_uniprotkb": "CCNB2; CYCB2", "gene_names_refseq": "CCNB2", "protein_names_uniprotkb": "G2/mitotic-specific cyclin-B2", "protein_names_refseq": "G2/mitotic-specific cyclin-B2", "tax_id": 9913, "disease": "", "pathway": " (bta:281668)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Essential for the control of the cell cycle at the G2/M (mitosis) transition., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q17QG1;Q5BIS1;Q5E9U8;Q5EAA0", "ec_number_list": [], "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0015630 microtubule cytoskeleton;GO:0005815 microtubule organizing center;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0051301 cell division;GO:0000082 G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O77689-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77769-1", "uniprot_id": [ { "id": "DHRS3_BOVIN", "url": "https://www.uniprot.org/uniprot/O77769", "type": "external" } ], "mass": 33496.0, "length": 302, "protein_name": "Short-chain dehydrogenase/reductase 3", "gene_name": "DHRS3", "organism": "Bovine", "refseq_name": "short-chain dehydrogenase/reductase 3", "refseq_ac": [ { "id": "NP_776605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776605", "type": "external" } ], "gene_names_uniprotkb": "DHRS3", "gene_names_refseq": "DHRS3; SDR1; retSDR1", "protein_names_uniprotkb": "Short-chain dehydrogenase/reductase 3; 1.1.1.300; Retinal short-chain dehydrogenase/reductase 1; retSDR1", "protein_names_refseq": "retinal short-chain dehydrogenase/reductase 1; short-chain dehydrogenase/reductase 1; short-chain dehydrogenase/reductase 3", "tax_id": 9913, "disease": "", "pathway": " (bta:281482)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9705317", "class_list": "", "function": "Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3MHX2", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.21", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" } ], "go_molecular_function": "GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity;GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0016020 membrane", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0048385 regulation of retinoic acid receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O77769-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77784-1", "uniprot_id": [ { "id": "IDH3B_BOVIN", "url": "https://www.uniprot.org/uniprot/O77784", "type": "external" } ], "mass": 42497.0, "length": 385, "protein_name": "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial", "gene_name": "IDH3B", "organism": "Bovine", "refseq_name": "isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform 2 precursor", "refseq_ac": [ { "id": "NP_001139344", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139344", "type": "external" } ], "gene_names_uniprotkb": "IDH3B", "gene_names_refseq": "IDH1; IDH3B; IDH3", "protein_names_uniprotkb": "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; IDH1; Isocitric dehydrogenase subunit beta; NAD(+)-isocitrate dehydrogenase subunit 1; NAD(+)-specific ICDH subunit beta", "protein_names_refseq": "NAD(+)-dependent isocitrate dehydrogenase subunit 3; NAD(+)-isocitrate dehydrogenase subunit 1; NAD(+)-specific ICDH subunit beta; isocitrate dehydrogenase (NAD(+)) 3 beta; isocitrate dehydrogenase 3 (NAD(+)) beta; isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform 2 precursor; isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; isocitric dehydrogenase subunit beta", "tax_id": 9913, "disease": "", "pathway": " (bta:613338); (R-BTA-71403)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10677231;28100784", "class_list": "", "function": "Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O77785;Q3MI01", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0051287 NAD binding;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005739 mitochondrion;GO:0045242 isocitrate dehydrogenase complex (NAD+)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006102 isocitrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "O77784-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77792-1", "uniprot_id": [ { "id": "UCP3_BOVIN", "url": "https://www.uniprot.org/uniprot/O77792", "type": "external" } ], "mass": 34206.0, "length": 311, "protein_name": "Putative mitochondrial transporter UCP3", "gene_name": "UCP3", "organism": "Bovine", "refseq_name": "putative mitochondrial transporter UCP3", "refseq_ac": [ { "id": "NP_776635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776635", "type": "external" } ], "gene_names_uniprotkb": "UCP3; SLC25A9", "gene_names_refseq": "UCP3", "protein_names_uniprotkb": "Putative mitochondrial transporter UCP3; Solute carrier family 25 member 9; UCP 3; Uncoupling protein 3", "protein_names_refseq": "UCP 3; mitochondrial uncoupling protein 3; putative mitochondrial transporter UCP3; solute carrier family 25 member 9; uncoupling protein 3 (mitochondrial, proton carrier)", "tax_id": 9913, "disease": "", "pathway": " (bta:281563); (R-BTA-167826)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "10582284;16775060;17785604;20857204;31355500", "class_list": "", "function": "A study evaluating the relationships of uncoupling protein 2 and 3 expression, SNP of mitochondrial DNA, and residual feed intake (RFI) in Angus steers selected to have high or low RFI is presented., [RefSeq, PubMed]; After transfection with bta-miR-152 inhibitor, the expression of UCP3 by mammary epithelial cells increased significantly, and the expression of PRKAA1 decreased, but the difference was not significant; in addition, the intracellular TAG content decreased significantly., [RefSeq, PubMed]; Putative transmembrane transporter that plays a role in mitochondrial metabolism via an as yet unclear mechanism. Originally, this mitochondrial protein was thought to act as a proton transmembrane transporter from the mitochondrial intermembrane space into the matrix, causing proton leaks through the inner mitochondrial membrane, thereby uncoupling mitochondrial membrane potential generation from ATP synthesis. However, this function is controversial and uncoupling may not be the function, or at least not the main function, but rather a consequence of more conventional metabolite transporter activity., [UniProtKB, UniProtKB]; The effect of single nucleotide polymorphisms in 6 genes and their associations with production factors in beef cattle are reported., [RefSeq, PubMed]; The objective of this study was to estimate the allele and genotype frequencies of the IGF-IR/TaqI, m-calpain/HhaI, and UCP-3/BglI polymorphisms and to determine association between these polymorphisms and growth traits in Chinese indigenous cattle breed., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9TVA1", "ec_number_list": [], "go_molecular_function": "GO:0015078 proton transmembrane transporter activity;GO:0017077 oxidative phosphorylation uncoupler activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:1901373 lipid hydroperoxide transport;GO:0009409 response to cold;GO:1990845 adaptive thermogenesis;GO:0120162 positive regulation of cold-induced thermogenesis;GO:1990542 mitochondrial transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O77792-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O77797-1", "uniprot_id": [ { "id": "AKAP3_BOVIN", "url": "https://www.uniprot.org/uniprot/O77797", "type": "external" } ], "mass": 94672.0, "length": 858, "protein_name": "A-kinase anchor protein 3", "gene_name": "AKAP3", "organism": "Bovine", "refseq_name": "A-kinase anchor protein 3", "refseq_ac": [ { "id": "NP_001094509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094509", "type": "external" } ], "gene_names_uniprotkb": "AKAP3; AKAP110", "gene_names_refseq": "AKAP3", "protein_names_uniprotkb": "A-kinase anchor protein 3; A-kinase anchor protein 110 kDa; AKAP 110; AKAP-3; PRKA3; Protein kinase A-anchoring protein 3", "protein_names_refseq": "A kinase (PRKA) anchor protein 3; A-kinase anchor protein 110 kDa; A-kinase anchor protein 3; AKAP 110; AKAP-3; PRKA3; protein kinase A-anchoring protein 3", "tax_id": 9913, "disease": "", "pathway": " (bta:281610)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10319321", "class_list": "", "function": "Structural component of sperm fibrous sheath. Required for the formation of the subcellular structure of the sperm flagellum, sperm motility and male fertility., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QQY3", "ec_number_list": [], "go_molecular_function": "GO:0051018 protein kinase A binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0001669 acrosomal vesicle;GO:0035686 sperm fibrous sheath;GO:0097228 sperm principal piece", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0045184 establishment of protein localization;GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O77797-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O97563-1", "uniprot_id": [ { "id": "TIMP4_BOVIN", "url": "https://www.uniprot.org/uniprot/O97563", "type": "external" } ], "mass": 25593.0, "length": 224, "protein_name": "Metalloproteinase inhibitor 4", "gene_name": "TIMP4", "organism": "Bovine", "refseq_name": "metalloproteinase inhibitor 4 precursor", "refseq_ac": [ { "id": "NP_001039336", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039336", "type": "external" } ], "gene_names_uniprotkb": "TIMP4", "gene_names_refseq": "TIMP4", "protein_names_uniprotkb": "Metalloproteinase inhibitor 4; TIMP-4; Tissue inhibitor of metalloproteinases 4", "protein_names_refseq": "TIMP-4; metalloproteinase inhibitor 4 precursor; metalloproteinase inhibitor 4; tissue inhibitor of metalloproteinases 4; tissue inhibitor of metalloproteinase", "tax_id": 9913, "disease": "", "pathway": " (bta:317694)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2KHW6", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:0034097 response to cytokine;GO:0009725 response to hormone", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O97563-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O97680-1", "uniprot_id": [ { "id": "THIO_BOVIN", "url": "https://www.uniprot.org/uniprot/O97680", "type": "external" } ], "mass": 11813.0, "length": 105, "protein_name": "Thioredoxin", "gene_name": "TXN", "organism": "Bovine", "refseq_name": "thioredoxin", "refseq_ac": [ { "id": "NP_776393", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776393", "type": "external" } ], "gene_names_uniprotkb": "TXN", "gene_names_refseq": "TXN", "protein_names_uniprotkb": "Thioredoxin; Trx", "protein_names_refseq": "thioredoxin; trx", "tax_id": 9913, "disease": "", "pathway": " (bta:280950); (R-BTA-2559580); (R-BTA-3299685); (R-BTA-499943); (R-BTA-5628897); (R-BTA-5676934); (R-BTA-844456)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "10727087", "class_list": "", "function": "Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VBX7;Q3ZBD8", "ec_number_list": [], "go_molecular_function": "GO:0015035 protein-disulfide reductase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0019725 cellular homeostasis;GO:0009314 response to radiation;GO:0043388 positive regulation of DNA binding", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O97680-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O97919-1", "uniprot_id": [ { "id": "CCL5_BOVIN", "url": "https://www.uniprot.org/uniprot/O97919", "type": "external" } ], "mass": 10059.0, "length": 91, "protein_name": "C-C motif chemokine 5", "gene_name": "CCL5", "organism": "Bovine", "refseq_name": "C-C motif chemokine 5 precursor", "refseq_ac": [ { "id": "NP_787021", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787021", "type": "external" } ], "gene_names_uniprotkb": "CCL5; SCYA5", "gene_names_refseq": "CCL5; RANTES", "protein_names_uniprotkb": "C-C motif chemokine 5; SIS-delta; Small-inducible cytokine A5; T-cell-specific protein RANTES", "protein_names_refseq": "C-C motif chemokine 5 precursor; C-C motif chemokine 5; SIS-delta; T-cell-specific protein RANTES; chemokine (C-C motif) ligand 5; small-inducible cytokine A5", "tax_id": 9913, "disease": "", "pathway": " (bta:327712); (R-BTA-380108); (R-BTA-418594)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "12964118;25064684", "class_list": "", "function": "CCL5 but not CCL2 mainly attract bovine classical monocytes and promote their differentiation into LPS-hypo-responsive macrophages., [RefSeq, PubMed]; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells., [UniProtKB, UniProtKB]; Decrease in sensitivity of HIV variants to RANTES neutralization during the course of progressive infection, but not during follow-up of long term survivors; data suggest a role for RANTES neutralization sensitivity of HIV-1 in AIDS pathogenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T192", "ec_number_list": [], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0004672 protein kinase activity;GO:0042056 chemoattractant activity;GO:0042803 protein homodimerization activity;GO:0030298 receptor signaling protein tyrosine kinase activator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007267 cell-cell signaling;GO:0010820 positive regulation of T cell chemotaxis;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O97919-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00767-1", "uniprot_id": [ { "id": "CTRB_BOVIN", "url": "https://www.uniprot.org/uniprot/P00767", "type": "external" } ], "mass": 25755.0, "length": 245, "protein_name": "Chymotrypsinogen B", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Chymotrypsinogen B; 3.4.21.1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "5649671", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0007586 digestion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P00767-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00976-1", "uniprot_id": [ { "id": "IBPC_BOVIN", "url": "https://www.uniprot.org/uniprot/P00976", "type": "external" } ], "mass": 7511.0, "length": 67, "protein_name": "Colostrum trypsin inhibitor", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Colostrum trypsin inhibitor; Colostrum BPI", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "11947537", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P00976-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00996-1", "uniprot_id": [ { "id": "ISK1_BOVIN", "url": "https://www.uniprot.org/uniprot/P00996", "type": "external" } ], "mass": 8467.0, "length": 79, "protein_name": "Serine protease inhibitor Kazal-type 1", "gene_name": "SPINK1", "organism": "Bovine", "refseq_name": "serine protease inhibitor Kazal-type 1 precursor", "refseq_ac": [ { "id": "NP_001020519", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020519", "type": "external" } ], "gene_names_uniprotkb": "SPINK1; PSTI", "gene_names_refseq": "SPINK1", "protein_names_uniprotkb": "Serine protease inhibitor Kazal-type 1; Pancreatic secretory trypsin inhibitor", "protein_names_refseq": "pancreatic secretory trypsin inhibitor; serine protease inhibitor Kazal-type 1 precursor; serine protease inhibitor, Kazal type 1", "tax_id": 9913, "disease": "", "pathway": " (bta:574092)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18054043;5135319;5769997", "class_list": "", "function": "In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production., [UniProtKB, UniProtKB]; Partially folded bovine pancreatic trypsin inhibitor analogues attain fully native structures when co-crystallized with S195A rat trypsin., [RefSeq, PubMed]; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q56K02", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P00996-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01000-1", "uniprot_id": [ { "id": "IAC1_BOVIN", "url": "https://www.uniprot.org/uniprot/P01000", "type": "external" } ], "mass": 7379.0, "length": 63, "protein_name": "Acrosin inhibitor 1", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Acrosin inhibitor 1; Acrosin inhibitor I; BUSI-I", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "6365719", "class_list": "", "function": "Strong inhibitor of acrosin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01000-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01260-1", "uniprot_id": [ { "id": "CALC_BOVIN", "url": "https://www.uniprot.org/uniprot/P01260", "type": "external" } ], "mass": 3596.0, "length": 32, "protein_name": "Calcitonin", "gene_name": "CALCA", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CALCA; CALC", "gene_names_refseq": "", "protein_names_uniprotkb": "Calcitonin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "5259773", "class_list": "", "function": "Calcitonin is a peptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Calcitonin function is mediated by the calcitonin receptor/CALCR and the CALCR-RAMP2 (AMYR2) receptor complex (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P01260-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01302-1", "uniprot_id": [ { "id": "PAHO_BOVIN", "url": "https://www.uniprot.org/uniprot/P01302", "type": "external" } ], "mass": 14376.0, "length": 131, "protein_name": "Pancreatic polypeptide prohormone", "gene_name": "PPY", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PPY", "gene_names_refseq": "", "protein_names_uniprotkb": "Pancreatic polypeptide prohormone", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "1734969;7831336", "class_list": "", "function": "Hormone secreted by pancreatic cells that acts as a regulator of pancreatic and gastrointestinal functions probably by signaling through the G protein-coupled receptor NPY4R2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0031841 neuropeptide Y receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0007631 feeding behavior", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P01302-1", "record_type": "protein", "filter_code": 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"refseq_name": "follitropin subunit beta precursor", "refseq_ac": [ { "id": "NP_776485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776485", "type": "external" } ], "gene_names_uniprotkb": "FSHB", "gene_names_refseq": "FSHB; FSH", "protein_names_uniprotkb": "Follitropin subunit beta; FSH-B; FSH-beta; Follicle-stimulating hormone beta subunit; Follitropin beta chain", "protein_names_refseq": "FSH-B; FSH-beta; class 1 follicle-stimulating hormone beta polypeptide; class 2 follicle-stimulating hormone beta polypeptide; follicle stimulating hormone beta subunit; follicle stimulating hormone, beta polypeptide; follicule stimulating hormone, beta polypeptide; follitropin beta chain; follitropin subunit beta precursor; follitropin subunit beta", "tax_id": 9913, "disease": "", "pathway": " (bta:281171); (R-BTA-209822); (R-BTA-375281); (R-BTA-418555)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "11502219;15189830;18829190;26472536;26478576;2840246;3092216;3096676", 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Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P05008-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05009-1", "uniprot_id": [ { "id": "IFNAC_BOVIN", "url": "https://www.uniprot.org/uniprot/P05009", "type": "external" } ], "mass": 21572.0, "length": 189, "protein_name": "Interferon alpha-C", "gene_name": "IFNAC", "organism": "Bovine", "refseq_name": "interferon alpha-C precursor", "refseq_ac": [ { "id": "NP_776510", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776510", "type": "external" } ], "gene_names_uniprotkb": "IFNAC", "gene_names_refseq": "IF1AG7; IFNAC", "protein_names_uniprotkb": "Interferon alpha-C", "protein_names_refseq": "interferon 1AG7; interferon alpha-C precursor; interferon alpha-C", "tax_id": 9913, "disease": "", "pathway": " (bta:281236)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12857912;3020355;3886658", "class_list": "", "function": "Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase., [UniProtKB]; Recombinant bovine respiratory syncytial virus lacking the NS proteins, and those lacking NS2 in particular, are strong inducers of IFN-alpha/beta in bovine nasal fibroblasts and bronchoalveolar macrophages., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P05009-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05010-1", "uniprot_id": [ { "id": "IFNAD_BOVIN", "url": "https://www.uniprot.org/uniprot/P05010", "type": "external" } ], "mass": 21318.0, "length": 189, "protein_name": "Interferon alpha-D", "gene_name": "IFNAD", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "IFNAD", "gene_names_refseq": "", "protein_names_uniprotkb": "Interferon alpha-D", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "3886658", "class_list": "", "function": "Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P05010-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05016-1", "uniprot_id": [ { "id": "IL2_BOVIN", "url": "https://www.uniprot.org/uniprot/P05016", "type": "external" } ], "mass": 17628.0, "length": 155, "protein_name": "Interleukin-2", "gene_name": "IL2", "organism": "Bovine", "refseq_name": "interleukin-2 precursor", "refseq_ac": [ { "id": "NP_851340", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851340", "type": "external" } ], "gene_names_uniprotkb": "IL2; IL-2", "gene_names_refseq": "IL-2; IL2; TCGF", "protein_names_uniprotkb": "Interleukin-2; IL-2; T-cell growth factor; TCGF", "protein_names_refseq": "T-cell growth factor; interleukin-2 precursor; interleukin2", "tax_id": 9913, "disease": "", "pathway": " (bta:280822); (R-BTA-5673001); (R-BTA-9020558); (R-BTA-912526)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "12906107;15869801;3486415;3517854", "class_list": "", "function": "Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells., [UniProtKB, UniProtKB]; Pretreatment of neonatal PBMC with IL-1beta, TNF-alpha or IFN-gamma promotes mitogenic response to ConA through up-regulating the production of IL-2 and the expression of the mature IL-2 receptor., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0MZP6;A9QWQ6;Q5QT38;Q8HYR7", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0005134 interleukin-2 receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0038110 interleukin-2-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0009891 positive regulation of biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P05016-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05785-1", "uniprot_id": [ { "id": "K1C14_BOVIN", "url": "https://www.uniprot.org/uniprot/P05785", "type": "external" } ], "mass": 10722.0, "length": 93, "protein_name": "Keratin, type I cytoskeletal 14", "gene_name": "KRT14", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "KRT14", "gene_names_refseq": "", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 14; CK-14; Cytokeratin VII; Cytokeratin-14; Cytokeratin-7; K14; Keratin-14", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "6209405", "class_list": "", "function": "Structural component of intermediate filaments in basal keratinocytes of stratified epithelia. Forms obligate heteropolymers with the type II keratin KRT5, contributing to the keratin intermediate filament network that confers mechanical strength and structural integrity to the basal layer of the epidermis and other stratified epithelial. The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005882 intermediate filament", "go_biological_process": "GO:0045110 intermediate filament bundle assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P05785-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06579-1", "uniprot_id": [ { "id": "TRBM_BOVIN", "url": "https://www.uniprot.org/uniprot/P06579", "type": "external" } ], "mass": 37795.0, "length": 356, "protein_name": "Thrombomodulin", "gene_name": "THBD", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "THBD", "gene_names_refseq": "", "protein_names_uniprotkb": "Thrombomodulin; Fetomodulin; TM", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "3024152", "class_list": "", "function": "Endothelial cell receptor that plays a critical role in regulating several physiological processes including hemostasis, coagulation, fibrinolysis, inflammation, and angiogenesis. Acts as a cofactor for thrombin activation of protein C/PROC on the surface of vascular endothelial cells leading to initiation of the activated protein C anticoagulant pathway. Also accelerates the activation of the plasma carboxypeptidase B2/CPB2, which catalyzes removal of C-terminal basic amino acids from its substrates including kinins or anaphylatoxins leading to fibrinolysis inhibition (By similarity). Plays critical protective roles in changing the cleavage specificity of protease-activated receptor 1/PAR1, inhibiting endothelial cell permeability and inflammation (By similarity). Suppresses inflammation distinctly from its anticoagulant cofactor activity by sequestering HMGB1 thereby preventing it from engaging cellular receptors such as RAGE and contributing to the inflammatory response (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P06579-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06642-1", "uniprot_id": [ { "id": "HBE2_BOVIN", "url": "https://www.uniprot.org/uniprot/P06642", "type": "external" } ], "mass": 16535.0, "length": 147, "protein_name": "Hemoglobin subunit epsilon-2", "gene_name": "HBE2", "organism": "Bovine", "refseq_name": "hemoglobin subunit epsilon-2", "refseq_ac": [ { "id": "NP_001014913", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014913", "type": "external" } ], "gene_names_uniprotkb": "HBE2", "gene_names_refseq": "HBE2", "protein_names_uniprotkb": "Hemoglobin subunit epsilon-2; Epsilon-2-globin; Hemoglobin epsilon-2 chain", "protein_names_refseq": "epsilon-2-globin; hemoglobin epsilon-2 chain; hemoglobin subunit epsilon-2; hemoglobin, beta, epsilon 2", "tax_id": 9913, "disease": "", "pathway": " (bta:513240)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "3870873", "class_list": "", "function": "Hemoglobin epsilon chain is a beta-type chain found in early embryos., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0031721 hemoglobin alpha binding;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity", "go_cellular_component": "GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0048821 erythrocyte development;GO:0015671 oxygen transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P06642-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06643-1", "uniprot_id": [ { "id": "HBE4_BOVIN", "url": "https://www.uniprot.org/uniprot/P06643", "type": "external" } ], "mass": 16514.0, "length": 147, "protein_name": "Hemoglobin subunit epsilon-4", "gene_name": "HBE4", "organism": "Bovine", "refseq_name": "hemoglobin subunit epsilon-4", "refseq_ac": [ { "id": "NP_001014910", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014910", "type": "external" } ], "gene_names_uniprotkb": "HBE4", "gene_names_refseq": "HBE4", "protein_names_uniprotkb": "Hemoglobin subunit epsilon-4; Epsilon-4-globin; Hemoglobin epsilon-4 chain", "protein_names_refseq": "epsilon-4-globin; globin, beta, epsilon 4; hemoglobin epsilon-4 chain; hemoglobin subunit epsilon-4", "tax_id": 9913, "disease": "", "pathway": " (bta:513108)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "3870873", "class_list": "", "function": "Hemoglobin epsilon chain is a beta-type chain found in early embryos., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0031721 hemoglobin alpha binding;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity", "go_cellular_component": "GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0048821 erythrocyte development;GO:0015671 oxygen transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P06643-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06833-1", "uniprot_id": [ { "id": "PYY2_BOVIN", "url": "https://www.uniprot.org/uniprot/P06833", "type": "external" } ], "mass": 8977.0, "length": 80, "protein_name": "Caltrin", "gene_name": "PYY2", "organism": "Bovine", "refseq_name": "caltrin precursor", "refseq_ac": [ { "id": "NP_776381", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776381", "type": "external" } ], "gene_names_uniprotkb": "PYY2", "gene_names_refseq": "PYY2; SPLN", "protein_names_uniprotkb": "Caltrin; Calcium transport inhibitor; Peptide YY-2; Peptide YY2; SPLN; Seminalplasmin", "protein_names_refseq": "calcium transport inhibitor; caltrin precursor; caltrin; peptide YY2", "tax_id": 9913, "disease": "", "pathway": " (bta:280905)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16453469;2206400;2334517;2423370;3863108;7786287;8485159", "class_list": "", "function": "Inhibits calcium transport into spermatozoa; it does not bind directly to calcium. Binds to calmodulin. Inhibits the growth of microorganisms. Seem to act as an antibiotic by permeabilizing the bacterial membrane., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005184 neuropeptide hormone activity;GO:0031841 neuropeptide Y receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0007631 feeding behavior;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P06833-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07033-1", "uniprot_id": [ { "id": "ACYP2_BOVIN", "url": "https://www.uniprot.org/uniprot/P07033", "type": "external" } ], "mass": 11178.0, "length": 99, "protein_name": "Acylphosphatase-2", "gene_name": "ACYP2", "organism": "Bovine", "refseq_name": "acylphosphatase-2", "refseq_ac": [ { "id": "NP_001106701", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106701", "type": "external" } ], "gene_names_uniprotkb": "ACYP2; ACYP", "gene_names_refseq": "ACYP2", "protein_names_uniprotkb": "Acylphosphatase-2; 3.6.1.7; Acylphosphatase, muscle type isozyme; Acylphosphate phosphohydrolase 2", "protein_names_refseq": "acylphosphatase 2, muscle type; acylphosphatase, muscle type isozyme; acylphosphatase-2; acylphosphate phosphohydrolase 2", "tax_id": 9913, "disease": "", "pathway": " (bta:767889)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "3011706", "class_list": "", "function": "catalyzes the hydrolysis of acylphosphates compounds containing a carboxylphosphate bond., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.7", "type": "external" } ], "go_molecular_function": "GO:0003998 acylphosphatase activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P07033-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07348-1", "uniprot_id": [ { "id": "IFNA1_BOVIN", "url": "https://www.uniprot.org/uniprot/P07348", "type": "external" } ], "mass": 21406.0, "length": 189, "protein_name": "Interferon alpha-1", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Interferon alpha-1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2985969", "class_list": "", "function": "Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P07348-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07352-1", "uniprot_id": [ { "id": "IFNW1_BOVIN", "url": "https://www.uniprot.org/uniprot/P07352", "type": "external" } ], "mass": 21980.0, "length": 195, "protein_name": "Interferon omega-1", "gene_name": "IFNW1", "organism": "Bovine", "refseq_name": "interferon omega-1 precursor", "refseq_ac": [ { "id": "NP_776776", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776776", "type": "external" } ], "gene_names_uniprotkb": "IFNW1; IFNW", "gene_names_refseq": "IF1BE8; IFNW1", "protein_names_uniprotkb": "Interferon omega-1; IFN-omega-c1; Interferon alpha-II-1", "protein_names_refseq": "IFN-omega-c1; interferon 1BE8; interferon alpha-II-1; interferon omega-1 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281847)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2985969", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P07352-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07435-1", "uniprot_id": [ { "id": "OBP_BOVIN", "url": "https://www.uniprot.org/uniprot/P07435", "type": "external" } ], "mass": 18503.0, "length": 159, "protein_name": "Odorant-binding protein", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Odorant-binding protein; OBP; Olfactory mucosa pyrazine-binding protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "1623143;2512125;3817156;8836103;8901871", "class_list": "", "function": "This protein binds a wide variety of chemical odorants., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036094 small molecule binding;GO:0005549 odorant binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P07435-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08209-1", "uniprot_id": [ { "id": "CRGD_BOVIN", "url": "https://www.uniprot.org/uniprot/P08209", "type": "external" } ], "mass": 20866.0, "length": 174, "protein_name": "Gamma-crystallin D", "gene_name": "CRYGD", "organism": "Bovine", "refseq_name": "gamma-crystallin D", "refseq_ac": [ { "id": "NP_776716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776716", "type": "external" } ], "gene_names_uniprotkb": "CRYGD", "gene_names_refseq": "CRYGD", "protein_names_uniprotkb": "Gamma-crystallin D; Gamma-D-crystallin; Gamma-crystallin IIIB", "protein_names_refseq": "gamma-D-crystallin; gamma-crystallin D; gamma-crystallin IIIB", "tax_id": 9913, "disease": "", "pathway": " (bta:281723)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15299634;18509547;3606621;7925695", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB]; The results are consistent with the hypothesis that short-range, weak, attractive interactions between alpha- and gamma-crystallins are necessary for maximum transparency of the lens. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q28089", "ec_number_list": [], "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P08209-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08814-1", "uniprot_id": [ { "id": "PTMS_BOVIN", "url": "https://www.uniprot.org/uniprot/P08814", "type": "external" } ], "mass": 11457.0, "length": 102, "protein_name": "Parathymosin", "gene_name": "PTMS", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PTMS", "gene_names_refseq": "", "protein_names_uniprotkb": "Parathymosin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "3421960", "class_list": "", "function": "Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P08814-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08858-1", "uniprot_id": [ { "id": "TKNK_BOVIN", "url": "https://www.uniprot.org/uniprot/P08858", "type": "external" } ], "mass": 13871.0, "length": 126, "protein_name": "Tachykinin-3", "gene_name": "TAC3", "organism": "Bovine", "refseq_name": "tachykinin-3 precursor", "refseq_ac": [ { "id": "NP_851360", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851360", "type": "external" } ], "gene_names_uniprotkb": "TAC3; NKNB", "gene_names_refseq": "TAC3", "protein_names_uniprotkb": "Tachykinin-3; Neuromedin-K", "protein_names_refseq": "neurokinin B, neuromedin K; tachykinin 3, neurokinin beta; tachykinin-3 precursor; tachykinin-3", "tax_id": 9913, "disease": "", "pathway": " (bta:281513); (R-BTA-380095); (R-BTA-416476)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "3462746", "class_list": "", "function": "Is a ligand for TACR3, and triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C (By similarity). Binding to TACR3 also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (By similarity). Is a critical central regulator of gonadal function (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0045777 positive regulation of blood pressure;GO:0007217 tachykinin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P08858-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09611-1", "uniprot_id": [ { "id": "CSH1_BOVIN", "url": "https://www.uniprot.org/uniprot/P09611", "type": "external" } ], "mass": 26909.0, "length": 236, "protein_name": "Chorionic somatomammotropin hormone 1", "gene_name": "CSH1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CSH1; PL1", "gene_names_refseq": "", "protein_names_uniprotkb": "Chorionic somatomammotropin hormone 1; BPLP-I; Placental lactogen I", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "2003877;2341410;3242594", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P09611-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C171-1", "uniprot_id": [ { "id": "TIP39_BOVIN", "url": "https://www.uniprot.org/uniprot/P0C171", "type": "external" } ], "mass": 11202.0, "length": 100, "protein_name": "Tuberoinfundibular peptide of 39 residues", "gene_name": "PTH2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PTH2; TIP39; TIPF39", "gene_names_refseq": "", "protein_names_uniprotkb": "Tuberoinfundibular peptide of 39 residues; Parathyroid hormone 2; TIP39", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "10526330;11046116", "class_list": "", "function": "Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action of PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0C171-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C1G6-1", "uniprot_id": [ { "id": "SWP70_BOVIN", "url": "https://www.uniprot.org/uniprot/P0C1G6", "type": "external" } ], "mass": 68921.0, "length": 585, "protein_name": "Switch-associated protein 70", "gene_name": "SWAP70", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SWAP70", "gene_names_refseq": "", "protein_names_uniprotkb": "Switch-associated protein 70; SWAP-70", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "11961559", "class_list": "", "function": "Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030027 lamellipodium", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C1G6-1", "record_type": "protein", "filter_code": "0000000.0100100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C7W1-1", "uniprot_id": [ { "id": "TOR2X_BOVIN", "url": "https://www.uniprot.org/uniprot/P0C7W1", "type": "external" } ], "mass": 26421.0, "length": 242, "protein_name": "Prosalusin", "gene_name": "TOR2A", "organism": "Bovine", "refseq_name": "torsin-2A isoform X1", "refseq_ac": [ { "id": "XP_005213359", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005213359", "type": "external" } ], "gene_names_uniprotkb": "TOR2A", "gene_names_refseq": "Prosalusin; TOR2A; Torsin-2A", "protein_names_uniprotkb": "Prosalusin; Torsin family 2 member A; Torsin-2A", "protein_names_refseq": "torsin-2A isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Salusin may be a endocrine and/or paracrine factor able to increase intracellular calcium concentrations and induce cell mitogenesis. Salusin may also be a potent hypotensive peptide (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0005179 hormone activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005635 nuclear envelope;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0C7W1-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C8S2-1", "uniprot_id": [ { "id": "DRAXI_BOVIN", "url": "https://www.uniprot.org/uniprot/P0C8S2", "type": "external" } ], "mass": 37314.0, "length": 337, "protein_name": "Draxin", "gene_name": "DRAXIN", "organism": "Bovine", "refseq_name": "draxin precursor", "refseq_ac": [ { "id": "NP_001181941", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181941", "type": "external" } ], "gene_names_uniprotkb": "DRAXIN", "gene_names_refseq": "C16H1orf187; DRAXIN", "protein_names_uniprotkb": "Draxin; Dorsal inhibitory axon guidance protein; Dorsal repulsive axon guidance protein", "protein_names_refseq": "dorsal repulsive axon guidance protein; draxin precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:506110)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0021516 dorsal spinal cord development;GO:0030900 forebrain development;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P0C8S2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10036-1", "uniprot_id": [ { "id": "PIT1_BOVIN", "url": "https://www.uniprot.org/uniprot/P10036", "type": "external" } ], "mass": 33039.0, "length": 291, "protein_name": "Pituitary-specific positive transcription factor 1", "gene_name": "POU1F1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "POU1F1; GHF-1; PIT-1; PIT1", "gene_names_refseq": "", "protein_names_uniprotkb": "Pituitary-specific positive transcription factor 1; GHF-1; Growth hormone factor 1; PIT-1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2902927", "class_list": "", "function": "Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P10036-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11052-1", "uniprot_id": [ { "id": "CSF2_BOVIN", "url": "https://www.uniprot.org/uniprot/P11052", "type": "external" } ], "mass": 16157.0, "length": 143, "protein_name": "Granulocyte-macrophage colony-stimulating factor", "gene_name": "CSF2", "organism": "Bovine", "refseq_name": "granulocyte-macrophage colony-stimulating factor precursor", "refseq_ac": [ { "id": "NP_776452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776452", "type": "external" } ], "gene_names_uniprotkb": "CSF2", "gene_names_refseq": "CSF2; CSF; GM-CSF; GMCSF", "protein_names_uniprotkb": "Granulocyte-macrophage colony-stimulating factor; CSF; Colony-stimulating factor; GM-CSF", "protein_names_refseq": "colony stimulating factor 2 (granulocyte-macrophage); granulocyte-macrophage colony-stimulating factor precursor; granulocyte-macrophage colony-stimulating factor", "tax_id": 9913, "disease": "", "pathway": " (bta:281095); (R-BTA-512988); (R-BTA-5673001); (R-BTA-912526)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "12935848;13679318;19797121;21339286;25078682;25982572;2678728;28379294;3062386;33524138", "class_list": "", "function": "CSF2 affect embryonic development and enhance embryo competence for posttransfer survival., [RefSeq, PubMed]; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes., [UniProtKB]; Data suggest exposure to maternal CSF2 from D5-D7 of development is fundamentally different for female/male blastocysts with respect to embryo elongation, characteristics of transcriptome/methylome, and endometrial interferon tau secretion at D15., [RefSeq, PubMed]; Immunolocalization studies confirmed the presence of granulocyte-macrophage colony stimulating factor(GM-CSF) in the germ cell line in bovine and human testes and addition of GM-CSF enhances several parameters of sperm motility, [RefSeq, PubMed]; It was concluded that CSF2 can act as a developmental programming agent but alone is not able to abolish the adverse effects of in vitro production on fetal characteristics., [RefSeq, PubMed]; Regulation of gene expression in the bovine blastocyst by colony-stimulating factor 2 is disrupted by CRISPR/Cas9-mediated deletion of CSF2RA., [RefSeq, PubMed]; The conceptus, through its secretion of IFN-tau, stimulates maternal epithelial expression of COX-2 and GM-CSF during the peri-attachment period in the cow., [RefSeq, PubMed]; The increase in calving rate caused by CSF2 treatment involves, in part, more extensive development of extraembryonic membranes and capacity of the conceptus to secrete IFNT2 at day 15 of pregnancy. Erratum:[Reproduction. 2014 Feb;147(2):XI], [RefSeq, PubMed]; These results demonstrated that bovine colonic cells seem capable to respond to E. bovis merozoite I infection by the upregulation of CXCL10 and GM-CSF gene transcription., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005129 granulocyte macrophage colony-stimulating factor receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1904075 positive regulation of trophectodermal cell proliferation;GO:0032747 positive regulation of interleukin-23 production;GO:0006955 immune response;GO:0045892 negative regulation of DNA-templated transcription;GO:0010744 positive regulation of macrophage derived foam cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P11052-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11842-1", "uniprot_id": [ { "id": "CRBA4_BOVIN", "url": "https://www.uniprot.org/uniprot/P11842", "type": "external" } ], "mass": 23860.0, "length": 210, "protein_name": "Beta-crystallin A4", "gene_name": "CRYBA4", "organism": "Bovine", "refseq_name": "beta-crystallin A4", "refseq_ac": [ { "id": "NP_776950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776950", "type": "external" } ], "gene_names_uniprotkb": "CRYBA4", "gene_names_refseq": "CRYBA4", "protein_names_uniprotkb": "Beta-crystallin A4; Beta-A4 crystallin", "protein_names_refseq": "beta A4 crystallin; beta-crystallin A4; lens structural protein", "tax_id": 9913, "disease": "", "pathway": " (bta:282204)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1874445;6698025", "class_list": "", "function": "Crystallins are the dominant structural components of the vertebrate eye lens., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "", "go_biological_process": "GO:0007601 visual perception;GO:0002088 lens development in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P11842-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12401-1", "uniprot_id": [ { "id": "PLRP2_BOVIN", "url": "https://www.uniprot.org/uniprot/P12401", "type": "external" } ], "mass": 30322.0, "length": 267, "protein_name": "Placental prolactin-related protein 2", "gene_name": "PRP2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PRP2", "gene_names_refseq": "", "protein_names_uniprotkb": "Placental prolactin-related protein 2; PRC-II; bPRCII", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2765528", "class_list": "", "function": "Placental prolactin-related proteins may play a specific role during gestation., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P12401-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12402-1", "uniprot_id": [ { "id": "PLRP3_BOVIN", "url": "https://www.uniprot.org/uniprot/P12402", "type": "external" } ], "mass": 25016.0, "length": 213, "protein_name": "Placental prolactin-related protein 3", "gene_name": "PRP3", "organism": "Bovine", "refseq_name": "placental prolactin-related protein 3 precursor", "refseq_ac": [ { "id": "NP_776585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776585", "type": "external" } ], "gene_names_uniprotkb": "PRP3", "gene_names_refseq": "PRP3", "protein_names_uniprotkb": "Placental prolactin-related protein 3; PRC-III; bPRCIII", "protein_names_refseq": "PRC-III; bPRCIII; placental prolactin-related protein 3 precursor; placental prolactin-related protein 3", "tax_id": 9913, "disease": "", "pathway": " (bta:281430)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2765528", "class_list": "", "function": "Placental prolactin-related proteins may play a specific role during gestation., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P12402-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13182-1", "uniprot_id": [ { "id": "CX6A1_BOVIN", "url": "https://www.uniprot.org/uniprot/P13182", "type": "external" } ], "mass": 12073.0, "length": 109, "protein_name": "Cytochrome c oxidase subunit 6A1, mitochondrial", "gene_name": "COX6A1", "organism": "Bovine", "refseq_name": "cytochrome c oxidase subunit 6A1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001071299", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071299", "type": "external" } ], "gene_names_uniprotkb": "COX6A1", "gene_names_refseq": "COX6A1; VIA L", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 6A1, mitochondrial; Cytochrome c oxidase polypeptide VIa-liver; Cytochrome c oxidase subunit SSG", "protein_names_refseq": "cytochrome c oxidase polypeptide VIa-liver; cytochrome c oxidase subunit 6A1, mitochondrial precursor; cytochrome c oxidase subunit 6A1, mitochondrial; cytochrome c oxidase subunit SSG; cytochrome c oxidase subunit VIa polypeptide 1; cytochrome-c oxidase", "tax_id": 9913, "disease": "", "pathway": " (bta:282199); (R-BTA-5628897); (R-BTA-611105); (R-BTA-9707564); (R-BTA-9864848)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "16704969;1720401;17266955;17302415;18021064;18430799;2844245", "class_list": "", "function": "After copper is reduced, electron transfer to oxidized heme a(3) is enhanced relative to the rate of entry of the first electron. Erratum:[J Biol Chem. 2006 Sep 8;281(36):26768], [RefSeq, PubMed]; Analysis of the peroxidase activity of mitochondrial cytochrome c oxidase peroxidase activity, [RefSeq, PubMed]; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]; Extended x-ray absorption spectroscopy analysis of Zn binding site(s) in bovine-heart cytochrome c oxidase and characterization of the inhibitory effect of internal zinc on respiratory activity and proton pumping reconstituted oxidase are presented., [RefSeq, PubMed]; Perturbation of an arginine guanidinium, probably Arg-438, lowers the energy of the transient charge-uncompensated electron-transfer intermediate by changing the charge distribution in response to heme-heme electron transfer, [RefSeq, PubMed]; The conserved glutamic acid 242 near the active site of CcO undergoes a protonation state-dependent conformational change, which provides a valve in the pumping mechanism., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q24JY9", "ec_number_list": [], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P13182-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13184-1", "uniprot_id": [ { "id": "CX7A2_BOVIN", "url": "https://www.uniprot.org/uniprot/P13184", "type": "external" } ], "mass": 9305.0, "length": 83, "protein_name": "Cytochrome c oxidase subunit 7A2, mitochondrial", "gene_name": "COX7A2", "organism": "Bovine", "refseq_name": "cytochrome c oxidase subunit 7A2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_787001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787001", "type": "external" } ], "gene_names_uniprotkb": "COX7A2; COX7AL", "gene_names_refseq": "COX7A2", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 7A2, mitochondrial; Cytochrome c oxidase subunit VIIa-L; Cytochrome c oxidase subunit VIIa-liver/heart", "protein_names_refseq": "VIIIC; cytochrome c oxidase polypeptide VIIa-liver/heart; cytochrome c oxidase subunit 7A2, mitochondrial precursor; cytochrome c oxidase subunit 7A2, mitochondrial; cytochrome c oxidase subunit VIIa polypeptide 2 (liver); cytochrome c oxidase subunit VIIa-L; cytochrome c oxidase subunit VIIa-liver/heart", "tax_id": 9913, "disease": "", "pathway": " (bta:327688)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1717471;2549516;28100784;2844245;8307562", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZX6", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV;GO:0098803 respiratory chain complex", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen;GO:0006119 oxidative phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P13184-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14622-1", "uniprot_id": [ { "id": "COX8A_BOVIN", "url": "https://www.uniprot.org/uniprot/P14622", "type": "external" } ], "mass": 7743.0, "length": 69, "protein_name": "Cytochrome c oxidase subunit 8A, mitochondrial", "gene_name": "COX8A", "organism": "Bovine", "refseq_name": "cytochrome c oxidase subunit 8A, mitochondrial precursor", "refseq_ac": [ { "id": "NP_776449", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776449", "type": "external" } ], "gene_names_uniprotkb": "COX8A; COX8L; COX8", "gene_names_refseq": "COX8A; COX8L; COX8", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 8A, mitochondrial; Cytochrome c oxidase polypeptide VIII-liver; Cytochrome c oxidase subunit 8-2; IX", "protein_names_refseq": "IX; cytochrome c oxidase polypeptide VIII-liver; cytochrome c oxidase subunit 8-2; cytochrome c oxidase subunit 8A (ubiquitous); cytochrome c oxidase subunit 8A, mitochondrial precursor; cytochrome c oxidase subunit 8A, mitochondrial; cytochrome c oxidase subunit CIX; cytochrome c oxidase subunit VIII-L; cytochrome c oxidase subunit VIIIA (ubiquitous)", "tax_id": 9913, "disease": "", "pathway": " (bta:281091)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1689292;2176624;2844245", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32PC5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006123 mitochondrial electron transport, cytochrome c to oxygen", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P14622-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17305-1", "uniprot_id": [ { "id": "STP1_BOVIN", "url": "https://www.uniprot.org/uniprot/P17305", "type": "external" } ], "mass": 6456.0, "length": 55, "protein_name": "Spermatid nuclear transition protein 1", "gene_name": "TNP1", "organism": "Bovine", "refseq_name": "spermatid nuclear transition protein 1", "refseq_ac": [ { "id": "NP_776624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776624", "type": "external" } ], "gene_names_uniprotkb": "TNP1", "gene_names_refseq": "TNP1", "protein_names_uniprotkb": "Spermatid nuclear transition protein 1; STP-1; TP-1", "protein_names_refseq": "STP-1; TP-1; spermatid nuclear transition protein 1; transition protein 1 (during histone to protamine replacement)", "tax_id": 9913, "disease": "", "pathway": " (bta:281537)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1457814;25904013;2777004;30370952", "class_list": "", "function": "Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction., [UniProtKB, UniProtKB]; Sequence analysis revealed a deletion of 'G' nucleotide in 3'UTR region of TNP1 and C>T SNP in intronic region of TNP2 gene. C>T SNP had a significant effect on initial progressive motility in purebred cattle and post-thaw motility in overall cattle population. RT-qPCR analysis did not reveal any significant variation in TNP1 and TNP2 gene expression among poorly motile and good quality spermatozoa of Vrindavani bulls., [RefSeq, PubMed]; We propose that SNPs on the TNP1 3'-UTR may help select semen quality trait in Chinese Holstein bulls in the dairy industry., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T027", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0001673 male germ cell nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0019953 sexual reproduction;GO:0006338 chromatin remodeling;GO:0030317 flagellated sperm motility;GO:0045892 negative regulation of DNA-templated transcription;GO:0007286 spermatid development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P17305-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18917-1", "uniprot_id": [ { "id": "PLRP4_BOVIN", "url": "https://www.uniprot.org/uniprot/P18917", "type": "external" } ], "mass": 27876.0, "length": 239, "protein_name": "Placental prolactin-related protein 4", "gene_name": "PRP4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PRP4", "gene_names_refseq": "", "protein_names_uniprotkb": "Placental prolactin-related protein 4; PLP-III", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2736246", "class_list": "", "function": "Placental prolactin-related proteins may play a specific role during gestation., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P18917-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19159-1", "uniprot_id": [ { "id": "CSH2_BOVIN", "url": "https://www.uniprot.org/uniprot/P19159", "type": "external" } ], "mass": 27714.0, "length": 238, "protein_name": "Chorionic somatomammotropin hormone 2", "gene_name": "CSH2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CSH2; PL2", "gene_names_refseq": "", "protein_names_uniprotkb": "Chorionic somatomammotropin hormone 2; BPLP-II; Placental lactogen II", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2341410", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005148 prolactin receptor binding;GO:0046872 metal ion binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0031667 response to nutrient levels;GO:0007565 female pregnancy;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0030879 mammary gland development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P19159-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19858-1", "uniprot_id": [ { "id": "LDHA_BOVIN", "url": "https://www.uniprot.org/uniprot/P19858", "type": "external" } ], "mass": 36598.0, "length": 332, "protein_name": "L-lactate dehydrogenase A chain", "gene_name": "LDHA", "organism": "Bovine", "refseq_name": "L-lactate dehydrogenase A chain", "refseq_ac": [ { "id": "NP_776524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776524", "type": "external" } ], "gene_names_uniprotkb": "LDHA", "gene_names_refseq": "LDHA", "protein_names_uniprotkb": "L-lactate dehydrogenase A chain; 1.1.1.27; LDH muscle subunit; LDH-A; LDH-M", "protein_names_refseq": "L-lactate dehydrogenase A chain; LDH muscle subunit; LDH-A; LDH-M", "tax_id": 9913, "disease": "", "pathway": " (bta:281274); (R-BTA-70268); (R-BTA-9861718)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "2210387", "class_list": "", "function": "Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H7E0", "ec_number_list": [ { "id": "1.1.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.27", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0004459 L-lactate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006089 lactate metabolic process;GO:0042867 pyruvate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P19858-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20811-1", "uniprot_id": [ { "id": "ICAL_BOVIN", "url": "https://www.uniprot.org/uniprot/P20811", "type": "external" } ], "mass": 75843.0, "length": 705, "protein_name": "Calpastatin", "gene_name": "CAST", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CAST", "gene_names_refseq": "", "protein_names_uniprotkb": "Calpastatin; Calpain inhibitor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "2804140;8181976", "class_list": "", "function": "Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P20811-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22571-1", "uniprot_id": [ { "id": "CNCG_BOVIN", "url": "https://www.uniprot.org/uniprot/P22571", "type": "external" } ], "mass": 9102.0, "length": 83, "protein_name": "Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma", "gene_name": "PDE6H", "organism": "Bovine", "refseq_name": "retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma", "refseq_ac": [ { "id": "NP_776847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776847", "type": "external" } ], "gene_names_uniprotkb": "PDE6H", "gene_names_refseq": "PDE6H", "protein_names_uniprotkb": "Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; 3.1.4.35; GMP-PDE gamma", "protein_names_refseq": "GMP-PDE gamma; phosphodiesterase 6H, cGMP-specific, cone, gamma; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma", "tax_id": 9913, "disease": "", "pathway": " (bta:281978)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2162841", "class_list": "", "function": "Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0030553 cGMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity", "go_cellular_component": "GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0045745 positive regulation of G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P22571-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22779-1", "uniprot_id": [ { "id": "CP2AX_BOVIN", "url": "https://www.uniprot.org/uniprot/P22779", "type": "external" } ], "mass": 2060.0, "length": 18, "protein_name": "Cytochrome P450 2A", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 2A; 1.14.14.1; Cytochrome OLF2; Olfactive cytochrome P450; P52", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2121272", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P22779-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23934-1", "uniprot_id": [ { "id": "NDUS6_BOVIN", "url": "https://www.uniprot.org/uniprot/P23934", "type": "external" } ], "mass": 13413.0, "length": 124, "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial", "gene_name": "NDUFS6", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial precursor", "refseq_ac": [ { "id": "NP_787004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787004", "type": "external" } ], "gene_names_uniprotkb": "NDUFS6", "gene_names_refseq": "IP13; NDUFS6", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; CI-13kD-A; Complex I-13kD-A; NADH-ubiquinone oxidoreductase 13 kDa-A subunit", "protein_names_refseq": "CI-13kD-A; NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial precursor; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; NADH-ubiquinone oxidoreductase 13 kDa-A subunit; complex I-13kD-A", "tax_id": 9913, "disease": "", "pathway": " (bta:327691); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "1518044;18721790;1907966", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P23934-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25068-1", "uniprot_id": [ { "id": "TAP_BOVIN", "url": "https://www.uniprot.org/uniprot/P25068", "type": "external" } ], "mass": 6954.0, "length": 64, "protein_name": "Tracheal antimicrobial peptide", "gene_name": "", "organism": "Bovine", "refseq_name": "tracheal antimicrobial peptide precursor", "refseq_ac": [ { "id": "NP_777201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777201", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "TAP", "protein_names_uniprotkb": "Tracheal antimicrobial peptide; TAP", "protein_names_refseq": "tracheal antimicrobial peptide precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:286837); (R-BTA-1461957); (R-BTA-1461973)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "19181355;2023943;21674298;23200820;23333196;8506305", "class_list": "", "function": "Has antibacterial activity in vitro against Escherichia coli, Staphylococcus aureus, Klebsiella pneumonia, and Pseudomonas aeruginosa. In addition, the peptide is active against Candida albicans, indicating a broad spectrum of activity., [UniProtKB]; Sequencing of exon 2 of the TAP gene from 23 cattle revealed a prevalent non-synonymous single nucleotide polymorphism (SNP) A137G, encoding either serine or asparagine at residue 20 of the mature peptide., [RefSeq, PubMed]; The production of tracheal antimicrobial peptide in mammary epithelial cells in reponse to bacteria, drugs, and prolactins is reported., [RefSeq, PubMed]; The results from this study clearly demonstrate the involvement of octamer transcription factor-1 in the regulation of tracheal antimicrobial peptide and lingual antimicrobial peptide expression., [RefSeq, PubMed]; Twenty four hours post E. coli stimulation, IL1b, IL6, IL8, TNF and LAP gene expression was decreased compared to 6h, whereas TAP and SAA3 expression was further increased to 209- and 3452-fold (P<0.05)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O97532", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P25068-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26377-1", "uniprot_id": [ { "id": "STP2_BOVIN", "url": "https://www.uniprot.org/uniprot/P26377", "type": "external" } ], "mass": 15241.0, "length": 132, "protein_name": "Nuclear transition protein 2", "gene_name": "TNP2", "organism": "Bovine", "refseq_name": "nuclear transition protein 2", "refseq_ac": [ { "id": "NP_776625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776625", "type": "external" } ], "gene_names_uniprotkb": "TNP2", "gene_names_refseq": "TNP2", "protein_names_uniprotkb": "Nuclear transition protein 2; TP-2; TP2", "protein_names_refseq": "TP-2; TP2; nuclear transition protein 2; transition protein 2 (during histone to protamine replacement)", "tax_id": 9913, "disease": "", "pathway": " (bta:281538)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1716912;24416221;30370952", "class_list": "", "function": "Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction., [UniProtKB, UniProtKB]; SNP g.1536 C>T in the TNP2 3'-UTR, which altered the binding of TNP2 with bta-miR-154, was found to be associated with the semen quality traits of Chinese Holstein bulls Publication Status: Online-Only, [RefSeq, PubMed]; Sequence analysis revealed a deletion of 'G' nucleotide in 3'UTR region of TNP1 and C>T SNP in intronic region of TNP2 gene. C>T SNP had a significant effect on initial progressive motility in purebred cattle and post-thaw motility in overall cattle population. RT-qPCR analysis did not reveal any significant variation in TNP1 and TNP2 gene expression among poorly motile and good quality spermatozoa of Vrindavani bulls., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32L25", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0000786 nucleosome", "go_biological_process": "GO:0007283 spermatogenesis;GO:0010954 positive regulation of protein processing;GO:0007340 acrosome reaction;GO:0007341 penetration of zona pellucida;GO:0035092 sperm DNA condensation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P26377-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26895-1", "uniprot_id": [ { "id": "IL7_BOVIN", "url": "https://www.uniprot.org/uniprot/P26895", "type": "external" } ], "mass": 20023.0, "length": 176, "protein_name": "Interleukin-7", "gene_name": "IL7", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "IL7", "gene_names_refseq": "", "protein_names_uniprotkb": "Interleukin-7; IL-7", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1266695)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1333837", "class_list": "", "function": "Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis. Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG. Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A5PKF2;A9QWR0", "ec_number_list": [], "go_molecular_function": "GO:0005139 interleukin-7 receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006955 immune response;GO:0043066 negative regulation of apoptotic process;GO:0030890 positive regulation of B cell proliferation;GO:0045453 bone resorption;GO:0038111 interleukin-7-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P26895-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26917-1", "uniprot_id": [ { "id": "SMS_BOVIN", "url": "https://www.uniprot.org/uniprot/P26917", "type": "external" } ], "mass": 12689.0, "length": 116, "protein_name": "Somatostatin", "gene_name": "SST", "organism": "Bovine", "refseq_name": "somatostatin precursor", "refseq_ac": [ { "id": "NP_776385", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776385", "type": "external" } ], "gene_names_uniprotkb": "SST", "gene_names_refseq": "SST", "protein_names_uniprotkb": "Somatostatin", "protein_names_refseq": "somatostatin precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:280932)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10100681;16764985;18519243;18619673;21523659;2899837", "class_list": "", "function": "Data show that PKA and PKC pathways are involved in the differential regulation of production of the neuropeptides (Met)enkephalin, galanin, somatostatin, NPY, and VIP., [RefSeq, PubMed]; Individuals with genotype AA of somatostatin had significantly lower body height, body length, hip width, and hucklebone width values compared to AG at 1.5 years old Publication Status: Online-Only, [RefSeq, PubMed]; Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin., [UniProtKB, UniProtKB]; May enhance low-glucose-induced glucagon release by pancreatic alpha cells. This effect may be mediated by binding to GPR107 and PKA activation (By similarity). May regulate cardiac contractile function (By similarity). May compromise cardiomyocyte viability. In the central nervous system, may impair memory retention and may affect hippocampal excitability. May also have anxiolytic and anorexigenic effects. May play a role in arterial pressure regulation (By similarity). May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The distribution and morphology of neurons containing somatostatin (SOM) was investigated in the amygdala (CA) of the pig., [RefSeq, PubMed]; The present study, provides evidence of pro-SST and SST receptor (SSTR1 and 2A) mRNA expression in ocular ciliary epithelium (CE)., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3Y5Z2", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P26917-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27117-1", "uniprot_id": [ { "id": "DCOR_BOVIN", "url": "https://www.uniprot.org/uniprot/P27117", "type": "external" } ], "mass": 51346.0, "length": 461, "protein_name": "Ornithine decarboxylase", "gene_name": "ODC1", "organism": "Bovine", "refseq_name": "ornithine decarboxylase", "refseq_ac": [ { "id": "NP_776555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776555", "type": "external" } ], "gene_names_uniprotkb": "ODC1; ODC", "gene_names_refseq": "ODC1", "protein_names_uniprotkb": "Ornithine decarboxylase; 4.1.1.17; ODC", "protein_names_refseq": "ornithine decarboxylase", "tax_id": 9913, "disease": "", "pathway": " (bta:281365); (R-BTA-350562); (R-BTA-351202)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10520448;7774801", "class_list": "", "function": "Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H7E8", "ec_number_list": [ { "id": "4.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.17", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" } ], "go_molecular_function": "GO:0004586 ornithine decarboxylase activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009615 response to virus;GO:0033387 putrescine biosynthetic process from arginine, via ornithine;GO:0042176 regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P27117-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29177-1", "uniprot_id": [ { "id": "MGMT_BOVIN", "url": "https://www.uniprot.org/uniprot/P29177", "type": "external" } ], "mass": 967.0, "length": 9, "protein_name": "Methylated-DNA--protein-cysteine methyltransferase", "gene_name": "MGMT", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MGMT", "gene_names_refseq": "", "protein_names_uniprotkb": "Methylated-DNA--protein-cysteine methyltransferase; 2.1.1.63; 6-O-methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA-alkyltransferase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2308822", "class_list": "", "function": "Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.63", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.63", "type": "external" } ], "go_molecular_function": "GO:0003908 methylated-DNA-[protein]-cysteine S-methyltransferase activity;GO:0003677 DNA binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006281 DNA repair;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P29177-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29392-1", "uniprot_id": [ { "id": "SPAD1_BOVIN", "url": "https://www.uniprot.org/uniprot/P29392", "type": "external" } ], "mass": 15036.0, "length": 134, "protein_name": "Spermadhesin-1", "gene_name": "SPADH1", "organism": "Bovine", "refseq_name": "spermadhesin-1 precursor", "refseq_ac": [ { "id": "NP_777041", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777041", "type": "external" } ], "gene_names_uniprotkb": "SPADH1", "gene_names_refseq": "SPADH1", "protein_names_uniprotkb": "Spermadhesin-1; ASFP; Acidic seminal fluid protein", "protein_names_refseq": "ASFP; acidic seminal fluid protein; spermadhesin-1 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:282373)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1543494;1898381;8181566;9334740", "class_list": "", "function": "Stimulates cell division and progesterone secretion of bovine granulosa cells in vitro in a potent and dose dependent manner. This protein appears to be a potent growth factor with effects on ovarian granulosa cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2YDJ6", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007338 single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P29392-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30535-1", "uniprot_id": [ { "id": "TSPO_BOVIN", "url": "https://www.uniprot.org/uniprot/P30535", "type": "external" } ], "mass": 18927.0, "length": 169, "protein_name": "Translocator protein", "gene_name": "TSPO", "organism": "Bovine", "refseq_name": "translocator protein", "refseq_ac": [ { "id": "NP_786970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786970", "type": "external" } ], "gene_names_uniprotkb": "TSPO; BZRP", "gene_names_refseq": "BZRP; TSPO", "protein_names_uniprotkb": "Translocator protein; IBP; Isoquinoline-binding protein; PBR; PKBS; Peripheral-type benzodiazepine receptor", "protein_names_refseq": "IBP; PBR; PKBS; benzodiazepine receptor (peripheral); isoquinoline-binding protein; peripheral-type benzodiazepine receptor; translocator protein", "tax_id": 9913, "disease": "", "pathway": " (bta:281033)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1649835", "class_list": "", "function": "Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:1649835)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZC36", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006869 lipid transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P30535-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30907-1", "uniprot_id": [ { "id": "AL3A1_BOVIN", "url": "https://www.uniprot.org/uniprot/P30907", "type": "external" } ], "mass": 26743.0, "length": 239, "protein_name": "Aldehyde dehydrogenase, dimeric NADP-preferring", "gene_name": "ALDH3A1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ALDH3A1; ALDH3", "gene_names_refseq": "", "protein_names_uniprotkb": "Aldehyde dehydrogenase, dimeric NADP-preferring; 1.2.1.5; Aldehyde dehydrogenase 3; Aldehyde dehydrogenase family 3 member A1; Corneal 15.8 kDa protein; Corneal protein 54; Transparentin; bCP54", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "1842923;2016061;2276277", "class_list": "", "function": "ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (By similarity). Preferentially oxidizes aromatic aldehyde substrates (By similarity). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.31", "type": "external" }, { "id": "1.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.8", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.2.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.19", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.47", "type": "external" }, { "id": "1.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.46", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" } ], "go_molecular_function": "GO:0004028 3-chloroallyl aldehyde dehydrogenase activity;GO:0004029 aldehyde dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006081 aldehyde metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P30907-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31098-1", "uniprot_id": [ { "id": "OSTK_BOVIN", "url": "https://www.uniprot.org/uniprot/P31098", "type": "external" } ], "mass": 30969.0, "length": 277, "protein_name": "Osteopontin-K", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Osteopontin-K", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "1414488", "class_list": "", "function": "Probably involved in cell adhesion., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 26, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050840 extracellular matrix binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007155 cell adhesion;GO:0045780 positive regulation of bone resorption;GO:0001649 osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P31098-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31783-1", "uniprot_id": [ { "id": "CD8A_BOVIN", "url": "https://www.uniprot.org/uniprot/P31783", "type": "external" } ], "mass": 26417.0, "length": 242, "protein_name": "T-cell surface glycoprotein CD8 alpha chain", "gene_name": "CD8A", "organism": "Bovine", "refseq_name": "T-cell surface glycoprotein CD8 alpha chain precursor", "refseq_ac": [ { "id": "NP_776440", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776440", "type": "external" } ], "gene_names_uniprotkb": "CD8A", "gene_names_refseq": "CD8A", "protein_names_uniprotkb": "T-cell surface glycoprotein CD8 alpha chain", "protein_names_refseq": "CD8 antigen, alpha polypeptide (p32); CD8a molecule; T-cell surface glycoprotein CD8 alpha chain precursor; T-cell surface glycoprotein CD8 alpha chain", "tax_id": 9913, "disease": "", "pathway": " (bta:281060)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1628904", "class_list": "", "function": "Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0002456 T cell mediated immunity;GO:0045065 cytotoxic T cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P31783-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32236-1", "uniprot_id": [ { "id": "GNRHR_BOVIN", "url": "https://www.uniprot.org/uniprot/P32236", "type": "external" } ], "mass": 37741.0, "length": 328, "protein_name": "Gonadotropin-releasing hormone receptor", "gene_name": "GNRHR", "organism": "Bovine", "refseq_name": "gonadotropin-releasing hormone receptor", "refseq_ac": [ { "id": "NP_803480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803480", "type": "external" } ], "gene_names_uniprotkb": "GNRHR", "gene_names_refseq": "GNRHR", "protein_names_uniprotkb": "Gonadotropin-releasing hormone receptor; GnRH receptor; GnRH-R", "protein_names_refseq": "gnRH receptor; gnRH-R; gonadotrophin-releasing hormone receptor; gonadotropin-releasing hormone receptor; luteinizing-releasing hormone receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:281798); (R-BTA-375281); (R-BTA-416476)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "19968639;21030057;21104139;23478821;8306635", "class_list": "", "function": "Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system., [UniProtKB]; Seven sequence variants (SVs) have been identified in exon 1 and in the promoter region upstream of the bovine gonadotrophin releasing hormone (GnRH) receptor; g.-108T>C alteration was associated with beneficial effects on fertility, [RefSeq, PubMed]; The GRIA1 polymorphism exists in beef cows but it does not influence antral follicle numbers. The association between GnRHR genotype and age at first calving is likely not causal as this polymorphism is not functional., [RefSeq, PubMed]; There was a significant correlation between frequency profile and timing of puberty among the studied breeds, which seems to suggest that genetic variation within bovine GNRHR gene could explain at least part of the reported variability. Erratum:[Res Vet Sci. 2025 Jul;190:105632. doi: 10.1016/j.rvsc.2025.105632. PMID: 40307098], [RefSeq, PubMed]; These results indicate that GnRHR gene can be a potential marker for improving sperm quality traits, and imply that bulls with GA or CT genotype should be selected in breeding program., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004968 gonadotropin-releasing hormone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0032870 cellular response to hormone stimulus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P32236-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35478-1", "uniprot_id": [ { "id": "CYTX_BOVIN", "url": "https://www.uniprot.org/uniprot/P35478", "type": "external" } ], "mass": 11603.0, "length": 101, "protein_name": "Stefin-C", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Stefin-C", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8463267", "class_list": "", "function": "Strong inhibitor of papain and cathepsin L but poor inhibitor of cathepsin B., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P35478-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35604-1", "uniprot_id": [ { "id": "COPZ1_BOVIN", "url": "https://www.uniprot.org/uniprot/P35604", "type": "external" } ], "mass": 20228.0, "length": 177, "protein_name": "Coatomer subunit zeta-1", "gene_name": "COPZ1", "organism": "Bovine", "refseq_name": "coatomer subunit zeta-1", "refseq_ac": [ { "id": "NP_776707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776707", "type": "external" } ], "gene_names_uniprotkb": "COPZ1; COPZ", "gene_names_refseq": "COPZ1", "protein_names_uniprotkb": "Coatomer subunit zeta-1; Zeta-1 COP; Zeta-1-coat protein", "protein_names_refseq": "Zeta-1 COP; coatomer protein complex subunit zeta 1; coatomer subunit zeta-1; zeta-1-coat protein", "tax_id": 9913, "disease": "", "pathway": " (bta:281707); (R-BTA-6807878); (R-BTA-6811434)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "16305752;8276893", "class_list": "", "function": "Component of the coatomer complex, involved in retrograde Golgi-to-ER transport (By similarity). The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5EA44", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030126 COPI vesicle coat", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P35604-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35662-1", "uniprot_id": [ { "id": "CYLC1_BOVIN", "url": "https://www.uniprot.org/uniprot/P35662", "type": "external" } ], "mass": 74817.0, "length": 667, "protein_name": "Cylicin-1", "gene_name": "CYLC1", "organism": "Bovine", "refseq_name": "cylicin-1", "refseq_ac": [ { "id": "NP_776727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776727", "type": "external" } ], "gene_names_uniprotkb": "CYLC1; CYL1; CYL", "gene_names_refseq": "CYLC1", "protein_names_uniprotkb": "Cylicin-1; Cylicin I; Multiple-band polypeptide I", "protein_names_refseq": "cylicin I; cylicin, basic protein of sperm head cytoskeleton 1; cylicin-1; multiple-band polypeptide I", "tax_id": 9913, "disease": "", "pathway": " (bta:281737)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8354692", "class_list": "", "function": "Plays a role in the establishment of normal sperm morphology during spermatogenesis and is required for acrosome attachment to the nuclear envelope., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0061827 sperm head;GO:0043159 acrosomal matrix;GO:0033150 cytoskeletal calyx", "go_biological_process": "GO:0007283 spermatogenesis;GO:0001675 acrosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P35662-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P37289-1", "uniprot_id": [ { "id": "PF2R_BOVIN", "url": "https://www.uniprot.org/uniprot/P37289", "type": "external" } ], "mass": 41032.0, "length": 362, "protein_name": "Prostaglandin F2-alpha receptor", "gene_name": "PTGFR", "organism": "Bovine", "refseq_name": "prostaglandin F2-alpha receptor", "refseq_ac": [ { "id": "NP_851368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851368", "type": "external" } ], "gene_names_uniprotkb": "PTGFR", "gene_names_refseq": "PTGFR", "protein_names_uniprotkb": "Prostaglandin F2-alpha receptor; PGF receptor; PGF2-alpha receptor; Prostanoid FP receptor", "protein_names_refseq": "FP prostanoid receptor; PGF receptor; PGF2-alpha receptor; prostaglandin F receptor (FP); prostaglandin F2-alpha receptor; prostanoid FP receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:282020)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "16717461;17574782;24856470;26319698;29276208;7508922;9197544", "class_list": "", "function": "COX-2 and FP receptor contribute via changes in amount and distribution to mechanisms associated with parturition., [RefSeq, PubMed]; Data suggest that OVGP1 expression in oviductal epithelial cells is enhanced by PGE2 via PTGER2-cAMP-PKA signaling, and reduced by PGF2alpha through PTGFR-Ca2+-PKC pathway. (OVGP1 = oviductal glycoprotein 1; PTGER2 = prostaglandin E2 receptor; PTGFR = prostaglandin F2-alpha receptor; PKA = cyclic AMP-dependent protein kinase; PKC = protein kinase C), [RefSeq, PubMed]; Data suggest that estradiol up-regulates mRNA and protein expression of 3 prostanoid receptors in oviduct smooth muscle: EP2/PTGER2 (prostaglandin E receptor 2); EP4/PTGER4 (prostaglandin E receptor 4); and FP/PTGFR (prostaglandin F2alpha receptor)., [RefSeq, PubMed]; Mapped to bovine chromosome 3., [RefSeq, PubMed]; Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF) and Fas were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle., [RefSeq, PubMed]; Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004958 prostaglandin F receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0033993 response to lipid", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P37289-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39872-1", "uniprot_id": [ { "id": "RL3_BOVIN", "url": "https://www.uniprot.org/uniprot/P39872", "type": "external" } ], "mass": 46024.0, "length": 403, "protein_name": "Large ribosomal subunit protein uL3", "gene_name": "RPL3", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein uL3", "refseq_ac": [ { "id": "NP_777140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777140", "type": "external" } ], "gene_names_uniprotkb": "RPL3", "gene_names_refseq": "RPL3", "protein_names_uniprotkb": "Large ribosomal subunit protein uL3; 60S ribosomal protein L3", "protein_names_refseq": "60S ribosomal protein L3; large ribosomal subunit protein uL3", "tax_id": 9913, "disease": "", "pathway": " (bta:282688); (R-BTA-156827); (R-BTA-1799339); (R-BTA-6791226); (R-BTA-72689); (R-BTA-72706); (R-BTA-975956); (R-BTA-975957); (R-BTA-9954709); (R-BTA-9954714); (R-BTA-9954716)", "pathway_count": 11, "publication_count": 3, "publication_id_list": "10684968;16305752;7948030", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5E9A8;Q9N0L7", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P39872-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P39873-1", "uniprot_id": [ { "id": "RNBR_BOVIN", "url": "https://www.uniprot.org/uniprot/P39873", "type": "external" } ], "mass": 18450.0, "length": 167, "protein_name": "Brain ribonuclease", "gene_name": "BRN", "organism": "Bovine", "refseq_name": "brain ribonuclease precursor", "refseq_ac": [ { "id": "NP_776316", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776316", "type": "external" } ], "gene_names_uniprotkb": "BRN", "gene_names_refseq": "BRB; BRN", "protein_names_uniprotkb": "Brain ribonuclease; 3.1.27.-; BRB", "protein_names_refseq": "brain ribonuclease precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:280720)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12802423;16949585;1754384;2331705;25078100;26773365;3243767;8587129", "class_list": "", "function": "A direct correlation between the number of cis-prolyl bonds in a native protein and the complexity with which it folds is shown in the folding of three structurally homologous proteins of the ribonuclease family, namely RNase A, onconase and angiogenin., [RefSeq, PubMed]; Brain ribonuclease, not RNase A, is the true bovine homolog of human RNase 1., [RefSeq, PubMed]; Data show that angiogenin isolated from cow milk induces the production of cytokines interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha in human leukocytes., [RefSeq, PubMed]; This study concluded that brain ribonuclease (BRB) is a hormonally and developmentally regulated gene in bovine GCs and may regulate E2 production during follicular growth in cattle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 2, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 2, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 2, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 11, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 31, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q1RMP6", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0004519 endonuclease activity;GO:0004540 RNA nuclease activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 4.3, "record_id": "P39873-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1100000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46160-1", "uniprot_id": [ { "id": "DEFB2_BOVIN", "url": "https://www.uniprot.org/uniprot/P46160", "type": "external" } ], "mass": 4649.0, "length": 40, "protein_name": "Beta-defensin 2", "gene_name": "DEFB2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DEFB2", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-defensin 2; BNBD-2; BNDB-2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8454635", "class_list": "", "function": "Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P46160-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46166-1", "uniprot_id": [ { "id": "DEFB8_BOVIN", "url": "https://www.uniprot.org/uniprot/P46166", "type": "external" } ], "mass": 4359.0, "length": 38, "protein_name": "Beta-defensin 8", "gene_name": "DEFB8", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DEFB8", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-defensin 8; BNBD-8; BNDB-8", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8454635", "class_list": "", "function": "Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P46166-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46169-1", "uniprot_id": [ { "id": "DFB11_BOVIN", "url": "https://www.uniprot.org/uniprot/P46169", "type": "external" } ], "mass": 6507.0, "length": 60, "protein_name": "Beta-defensin 11", "gene_name": "DEFB11", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DEFB11; BNBD11", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-defensin 11; BNBD-11; BNDB-11; Neutrophil beta-defensin 11", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "15520886;8454635", "class_list": "", "function": "Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5W5G7", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P46169-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46170-1", "uniprot_id": [ { "id": "DFB12_BOVIN", "url": "https://www.uniprot.org/uniprot/P46170", "type": "external" } ], "mass": 4106.0, "length": 38, "protein_name": "Beta-defensin 12", "gene_name": "DEFB12", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DEFB12", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-defensin 12; BNBD-12; BNDB-12", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "7577957;8454635;8454636", "class_list": "", "function": "Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0042581 specific granule", "go_biological_process": "GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P46170-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46171-1", "uniprot_id": [ { "id": "DFB13_BOVIN", "url": "https://www.uniprot.org/uniprot/P46171", "type": "external" } ], "mass": 4450.0, "length": 42, "protein_name": "Beta-defensin 13", "gene_name": "DEFB13", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DEFB13", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-defensin 13; BNBD-13; BNDB-13", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8454635", "class_list": "", "function": "Has bactericidal activity. Active against E.coli ML35 and S.aureus 502A., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P46171-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46200-1", "uniprot_id": [ { "id": "MYB_BOVIN", "url": "https://www.uniprot.org/uniprot/P46200", "type": "external" } ], "mass": 72511.0, "length": 640, "protein_name": "Transcriptional activator Myb", "gene_name": "MYB", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MYB", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcriptional activator Myb; Proto-oncogene c-Myb", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7929419", "class_list": "", "function": "Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P46200-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46446-1", "uniprot_id": [ { "id": "ACY2_BOVIN", "url": "https://www.uniprot.org/uniprot/P46446", "type": "external" } ], "mass": 35738.0, "length": 313, "protein_name": "Aspartoacylase", "gene_name": "ASPA", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ASPA; ACY2", "gene_names_refseq": "", "protein_names_uniprotkb": "Aspartoacylase; 3.5.1.15; ACY-2; Aminoacylase-2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8252036", "class_list": "", "function": "Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it acts as a scavenger of NAA from body fluids., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.15", "type": "external" } ], "go_molecular_function": "GO:0016788 hydrolase activity, acting on ester bonds;GO:0019807 aspartoacylase activity;GO:0046872 metal ion binding;GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P46446-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48803-1", "uniprot_id": [ { "id": "FGF4_BOVIN", "url": "https://www.uniprot.org/uniprot/P48803", "type": "external" } ], "mass": 22042.0, "length": 206, "protein_name": "Fibroblast growth factor 4", "gene_name": "FGF4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FGF4; HST", "gene_names_refseq": "", "protein_names_uniprotkb": "Fibroblast growth factor 4; FGF-4; HBGF-4; HST; Heparin secretory-transforming protein; Heparin-binding growth factor 4", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7557455", "class_list": "", "function": "Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis (By similarity). May play a role in embryonic molar tooth bud development via inducing the expression of MSX1, MSX2 and MSX1-mediated expression of SDC1 in dental mesenchyme cells (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0051781 positive regulation of cell division;GO:0030334 regulation of cell migration;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P48803-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49220-1", "uniprot_id": [ { "id": "UR2R_BOVIN", "url": "https://www.uniprot.org/uniprot/P49220", "type": "external" } ], "mass": 42316.0, "length": 384, "protein_name": "Urotensin-2 receptor", "gene_name": "UTS2R", "organism": "Bovine", "refseq_name": "urotensin-2 receptor", "refseq_ac": [ { "id": "NP_001035574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035574", "type": "external" } ], "gene_names_uniprotkb": "UTS2R; GPR14", "gene_names_refseq": "Gpr14; SENR; UR-2-R; UTS2R", "protein_names_uniprotkb": "Urotensin-2 receptor; G protein-coupled receptor 14; G protein-coupled sensory epithelial neuropeptide-like receptor; SENR; UR-2-R; UR-II-R; Urotensin II receptor", "protein_names_refseq": "G protein-coupled receptor 14; G-protein coupled sensory epithelial neuropeptide-like receptor; UR-II-R; urotensin II receptor; urotensin receptor; urotensin-2 receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:286969)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16305752;18463714;24851282;7733947", "class_list": "", "function": "G protein-coupled receptor for the vasoactive neuropeptides urotensin-2 and urotensin-2B. Upon ligand binding, activates intracellular signaling cascades via G protein coupling, primarily through Gq/11, leading to phospholipase C activation, increased intracellular calcium, and activation of protein kinase C (PKC). Through coupling to G(i)/G(o) alpha subunits, stimulates MAPK/ERK pathways and thereby contributes to regulation of vascular tone, cardiac contractility, and cell proliferation. Ligand binding also triggers a marked reduction in the biogenesis of autophagosomes by inhibiting the recruitment of ATG16L1 to pre-autophagosomal endocytic vesicles., [UniProtKB, UniProtKB]; The role of urotensin 2 and urotensin 2 receptors in the skeletal muscle fat accumulation and fatty acid metabolism, thus indicating their potential pathological functions related to obesity and type 2 diabetes in humans. Publication Status: Online-Only, [RefSeq, PubMed]; These results suggested that these genotypes would contribute to production of high-grade meat as selection markers in beef cattle., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q58DI3", "ec_number_list": [], "go_molecular_function": "GO:0001604 urotensin II receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0008217 regulation of blood pressure;GO:0097746 blood vessel diameter maintenance", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P49220-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49355-1", "uniprot_id": [ { "id": "FNTB_BOVIN", "url": "https://www.uniprot.org/uniprot/P49355", "type": "external" } ], "mass": 48768.0, "length": 437, "protein_name": "Protein farnesyltransferase subunit beta", "gene_name": "FNTB", "organism": "Bovine", "refseq_name": "protein farnesyltransferase subunit beta", "refseq_ac": [ { "id": "NP_786999", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786999", "type": "external" } ], "gene_names_uniprotkb": "FNTB", "gene_names_refseq": "FNTB", "protein_names_uniprotkb": "Protein farnesyltransferase subunit beta; 2.5.1.58; CAAX farnesyltransferase subunit beta; FTase-beta; Ras proteins prenyltransferase subunit beta", "protein_names_refseq": "CAAX farnesyltransferase subunit beta; FTase-beta; protein farnesyltransferase subunit beta; ras proteins prenyltransferase subunit beta", "tax_id": 9913, "disease": "", "pathway": " (bta:327686); (R-BTA-2514859); (R-BTA-9648002); (R-BTA-9953170)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "8494894", "class_list": "", "function": "Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4FUX0;Q9TS25", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.5.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.58", "type": "external" }, { "id": "2.5.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.59", "type": "external" } ], "go_molecular_function": "GO:0004660 protein farnesyltransferase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005965 protein farnesyltransferase complex", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0018343 protein farnesylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P49355-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49449-1", "uniprot_id": [ { "id": "CENPA_BOVIN", "url": "https://www.uniprot.org/uniprot/P49449", "type": "external" } ], "mass": 15678.0, "length": 138, "protein_name": "Histone H3-like centromeric protein A", "gene_name": "CENPA", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CENPA", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone H3-like centromeric protein A; CENP-A; Centromere protein A", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "16305752;2023923;7962047", "class_list": "", "function": "Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000776 kinetochore;GO:0043505 CENP-A containing nucleosome", "go_biological_process": "GO:0051382 kinetochore assembly;GO:0071459 protein localization to chromosome, centromeric region;GO:0007080 mitotic metaphase chromosome alignment;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P49449-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49875-1", "uniprot_id": [ { "id": "IL3_BOVIN", "url": "https://www.uniprot.org/uniprot/P49875", "type": "external" } ], "mass": 16380.0, "length": 144, "protein_name": "Interleukin-3", "gene_name": "IL3", "organism": "Bovine", "refseq_name": "interleukin-3 precursor", "refseq_ac": [ { "id": "NP_776345", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776345", "type": "external" } ], "gene_names_uniprotkb": "IL3", "gene_names_refseq": "IL3", "protein_names_uniprotkb": "Interleukin-3; Hematopoietic growth factor; IL-3; MCGF; Mast cell growth factor; Multipotential colony-stimulating factor; P-cell-stimulating factor", "protein_names_refseq": "IL-3; MCGF; P-cell-stimulating factor; colony-stimulating factor, multiple; hematopoietic growth factor; interleukin 3 (colony-stimulating factor, multiple); interleukin-3 precursor; mast cell growth factor; multipotential colony-stimulating factor", "tax_id": 9913, "disease": "", "pathway": " (bta:280823); (R-BTA-512988); (R-BTA-5673001); (R-BTA-912526)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "7557449", "class_list": "", "function": "Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages., [UniProtKB]; This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005135 interleukin-3 receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0038156 interleukin-3-mediated signaling pathway;GO:0006955 immune response;GO:0008284 positive regulation of cell population proliferation;GO:0009891 positive regulation of biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P49875-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50154-1", "uniprot_id": [ { "id": "GBGT2_BOVIN", "url": "https://www.uniprot.org/uniprot/P50154", "type": "external" } ], "mass": 7728.0, "length": 69, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2", "gene_name": "GNGT2", "organism": "Bovine", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2", "refseq_ac": [ { "id": "NP_776753", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776753", "type": "external" } ], "gene_names_uniprotkb": "GNGT2; GNG8; GNGT8", "gene_names_refseq": "GNGT2; HG3I", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2; G gamma-C; G-gamma-8", "protein_names_refseq": "G-gamma-8; g gamma-C; guanidine nucleotide binding protein, (G protein), gamma transducing activity polypeptide 1; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2; heterotrimeric guanine nucleotide-binding protein 3I", "tax_id": 9913, "disease": "", "pathway": " (bta:281797); (R-BTA-1296041); (R-BTA-202040); (R-BTA-381676); (R-BTA-392170); (R-BTA-392451); (R-BTA-392851); (R-BTA-400042); (R-BTA-4086398); (R-BTA-416476); (R-BTA-416482); (R-BTA-418217); (R-BTA-418555); (R-BTA-418592); (R-BTA-418594); (R-BTA-418597); (R-BTA-420092); (R-BTA-428930); (R-BTA-432040); (R-BTA-456926); (R-BTA-500657); (R-BTA-6814122); (R-BTA-8964315); (R-BTA-8964616); (R-BTA-9009391); (R-BTA-9856530); (R-BTA-997272)", "pathway_count": 27, "publication_count": 1, "publication_id_list": "7721746", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QLH8", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0003924 GTPase activity", "go_cellular_component": "GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P50154-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50291-1", "uniprot_id": [ { "id": "FST_BOVIN", "url": "https://www.uniprot.org/uniprot/P50291", "type": "external" } ], "mass": 37958.0, "length": 344, "protein_name": "Follistatin", "gene_name": "FST", "organism": "Bovine", "refseq_name": "follistatin precursor", "refseq_ac": [ { "id": "NP_786995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786995", "type": "external" } ], "gene_names_uniprotkb": "FST", "gene_names_refseq": "FST", "protein_names_uniprotkb": "Follistatin; Activin-binding protein; FS", "protein_names_refseq": "FS; activin-binding protein; follistatin precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:327681); (R-BTA-2473224)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "19179440;25001504;25031360;30306773;8011323", "class_list": "", "function": "A functional role for oocyte-derived follistatin in bovine early embryogenesis., [RefSeq, PubMed]; Data suggest that SMAD4 (SMAD family member 4) mRNA is increased in oocytes during maturation, is maximal in 2-cell blastocysts, remains elevated through 8-cell stage, and then decreases; embryotrophic actions of FST are SMAD4 dependent., [RefSeq, PubMed]; Much higher expression in granulosa cells than in theca cells Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctional regulatory protein whose primary function is to antagonize members of the transforming growth factor beta (TGF-beta) superfamily including activin, myostatin, GDF11 or bone morphogenetic proteins (BMPs). Mechanistically, binds to these ligands in the extracellular space, blocking their type II receptor-binding site to inhibit downstream signaling (By similarity). Plays an essential role in muscle fiber formation and growth both by preventing the repressive effects of myostatin and through SMAD3/AKT/mTOR signaling independently of myostatin (By similarity). Also promotes neural differentiation by antagonizing the action BMP4 (By similarity). Acts as a specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) by sequestering activin A/INHBA. On the other hand, translocates into the nucleus where it down-regulates rRNA synthesis and ribosome biogenesis to maintain cellular energy homeostasis by binding to rDNA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The expression of the components of the activin-inhibin-follistatin system is altered in bovine cystic ovarian disease., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q32XW5", "ec_number_list": [], "go_molecular_function": "GO:0048185 activin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005730 nucleolus", "go_biological_process": "GO:0030154 cell differentiation;GO:0032926 negative regulation of activin receptor signaling pathway;GO:0030510 regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P50291-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51694-1", "uniprot_id": [ { "id": "PYY_BOVIN", "url": "https://www.uniprot.org/uniprot/P51694", "type": "external" } ], "mass": 11092.0, "length": 97, "protein_name": "Peptide YY", "gene_name": "PYY", "organism": "Bovine", "refseq_name": "peptide YY precursor", "refseq_ac": [ { "id": "NP_001035677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035677", "type": "external" } ], "gene_names_uniprotkb": "PYY", "gene_names_refseq": "PYY", "protein_names_uniprotkb": "Peptide YY; PYY; Peptide tyrosine tyrosine", "protein_names_refseq": "peptide YY precursor; peptide tyrosine tyrosine", "tax_id": 9913, "disease": "", "pathway": " (bta:615800); (R-BTA-375276); (R-BTA-418594)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "7831336", "class_list": "", "function": "Ligand for neuropeptide Y receptor type 1 (NPY1R) and neuropeptide Y receptor type 2 (NPY2R). Also binds NPY5R. Receptor binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production. Receptor activation by PYY also leads to an increase of intracellular Ca(2+) levels (By similarity). This gut peptide inhibits exocrine pancreatic secretion (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity). Involved in the down-regulation of appetite and food intake, probably acting on receptors located on proopiomelanocortin(POMC)-releasing and neuropeptide Y(NPY)-releasing neurons in the arcuate nucleus of hypothalamus (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T155", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0031841 neuropeptide Y receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1903999 negative regulation of eating behavior;GO:0007218 neuropeptide signaling pathway;GO:0007631 feeding behavior", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P51694-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52898-1", "uniprot_id": [ { "id": "AK1C4_BOVIN", "url": "https://www.uniprot.org/uniprot/P52898", "type": "external" } ], "mass": 43554.0, "length": 387, "protein_name": "Aldo-keto reductase family 1 member C4", "gene_name": "AKR1C4", "organism": "Bovine", "refseq_name": "aldo-keto reductase family 1 member C4", "refseq_ac": [ { "id": "NP_851370", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851370", "type": "external" } ], "gene_names_uniprotkb": "AKR1C4", "gene_names_refseq": "AKR1C1; AKR1C4; CDR", "protein_names_uniprotkb": "Aldo-keto reductase family 1 member C4; 1.1.1.-; 1.1.1.209; 1.1.1.210; 1.1.1.225; 1.1.1.357; 1.1.1.51; 1.1.1.53; 1.1.1.62; 3-alpha-HSD1; 3-alpha-hydroxysteroid 3-dehydrogenase type I; CDR; Chlordecone reductase", "protein_names_refseq": "20-alpha (3-alpha)-hydroxysteroid dehydrogenase); 3-alpha-HSD1; 3-alpha-hydroxysteroid 3-dehydrogenase type I; aldo-keto reductase family 1 member C4; aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; chlordecone reductase; dihydrodiol dehydrogenase 3; prostaglandin F synthase", "tax_id": 9913, "disease": "", "pathway": " (bta:282138); (R-BTA-193368); (R-BTA-193775); (R-BTA-193807); (R-BTA-2162123); (R-BTA-5365859); (R-BTA-975634); (R-BTA-9757110)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Cytosolic aldo-keto reductase that catalyzes NADPH-dependent reduction of ketosteroids to hydroxysteroids. Displays broad substrate specificity with distinct positional and stereochemistry, primarily generating 3alpha/beta-, 17beta- and 20alpha-hydroxysteroids. Required for male sex determination as a component of the 'backdoor' androgen biosynthesis pathway that generates 5alpha-dihydrotestosterone (5alpha-DHT) via pregnanes. Acts together with AKR1C2 to convert 5alpha-dihydroprogesterone (5alpha-DHP) to 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alpha-THP/allopregnanolone), leading to 5alpha-DHT secretion necessary for embryonic gonad differentiation into testis. May regulate the concentrations of circulating neurosteroids. Reduces 5alpha-dihydroprogesterone (5-alpha-DHP) and 5alpha-dihydrodeoxycorticosterone (5-alpha-DHDOC) precursors to 3alpha-hydroxy-5alpha-pregnan-20-one (3alpha,5alpha-THP/allopregnanolone) and 3alpha,21-dihydroxy-5alpha-pregnane-20-one (3alpha,5alpha-THDOC) neuroactive steroids known to alter neural excitability via allosteric activation of gamma-aminobutyric acid type A receptors (GABAAR). Regulates ligand availability for steroid hormone receptors. Catalyzes the inactivation of 5alpha-DHT and progesterone converting them into 3alpha/beta-androstanediols and (20S)-hydroxypregn-4-en-3-one, respectively. May contribute to the metabolism of adrenal-derived androgens via reduction of 11-keto-5alpha-androstane-3,17-dione (11K-Adione) into 11-ketoandrosterone (11KAST) and of 11-ketodihydrotestosterone (11KDHT) into 11-keto-5alpha-androstane-3alpha/beta,17beta-diol (11K-A3diol). Catalyzes the reduction of estrone into 17beta-estradiol but with low efficiency. In androgen catabolism, may predominantly act as a phase I enzyme by introducing a hydroxyl group prior to conjugation. It can nevertheless participate in the alternative phase II pathway by directly reducing sulfate- or glucuronide-conjugated androgens. Catalyzes the biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol, leading to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route. In vitro can efficiently catalyze bidirectional conversion between ketosteroids and hydroxysteroids using NADPH/NADP(+) or NADH/NAD(+) as cofactors. In vivo however, the reductase activity prevails since the major reducing cofactor NADPH inhibits NAD(+)-dependent oxidase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "M0QW16;Q2KIT3", "ec_number_list": [ { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "1.1.1.n12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12", "type": "external" }, { "id": "1.1.1.330", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.330", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.357", "type": "external" }, { "id": "1.1.1.188", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.188", "type": "external" }, { "id": "1.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.64", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" }, { "id": "1.1.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.225", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.51", "type": "external" }, { "id": "1.1.1.315", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.315", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.270", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" } ], "go_molecular_function": "GO:0004032 aldose reductase (NADPH) activity;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0047023 androsterone dehydrogenase [NAD(P)+] activity;GO:0047743 chlordecone reductase activity;GO:0032052 bile acid binding", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006693 prostaglandin metabolic process;GO:0044597 daunorubicin metabolic process;GO:0044598 doxorubicin metabolic process;GO:0042448 progesterone metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P52898-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53346-1", "uniprot_id": [ { "id": "ONCM_BOVIN", "url": "https://www.uniprot.org/uniprot/P53346", "type": "external" } ], "mass": 27554.0, "length": 245, "protein_name": "Oncostatin-M", "gene_name": "OSM", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "OSM", "gene_names_refseq": "", "protein_names_uniprotkb": "Oncostatin-M; OSM", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7739518", "class_list": "", "function": "Functions as a cytokine that uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST) (By similarity). Functionally, regulates many processes including cell proliferation, cell differentiation, cytokine production (PubMed:7739518). Mechanistically, low affinity ligand binding to IL6ST/gp130, induces heterodimerization with LIFR or OSMR, activating JAK tyrosine kinases (JAK1 or JAK2 and to a lesser extent TYK2) bound to their intracellular domains. These kinases subsequently phosphorylate IL6ST/gp130 and LIFR. The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of STAT3. The type II OSM complex receptor is also able in addition to STAT3 to recruit STAT5B. Moreover, the type II OSM complex receptor recruits SHC1 through OSMR in a JAK1 mediated phosphotyrosine-dependent manner, leading to SHC1 association with GRB2 and downstream activation of the Ras/Raf/MAPK pathway (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005147 oncostatin-M receptor binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0038165 oncostatin-M-mediated signaling pathway;GO:0006955 immune response;GO:0023051 regulation of signaling;GO:0010646 regulation of cell communication;GO:0009891 positive regulation of biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P53346-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53348-1", "uniprot_id": [ { "id": "BTG1_BOVIN", "url": "https://www.uniprot.org/uniprot/P53348", "type": "external" } ], "mass": 19195.0, "length": 171, "protein_name": "Protein BTG1", "gene_name": "BTG1", "organism": "Bovine", "refseq_name": "protein BTG1", "refseq_ac": [ { "id": "NP_776424", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776424", "type": "external" } ], "gene_names_uniprotkb": "BTG1", "gene_names_refseq": "BTG1", "protein_names_uniprotkb": "Protein BTG1; B-cell translocation gene 1 protein; Myocardial vascular inhibition factor; VIF", "protein_names_refseq": "B-cell translocation gene 1 protein; B-cell translocation gene 1, anti-proliferative; VIF; myocardial vascular inhibition factor; protein BTG1", "tax_id": 9913, "disease": "", "pathway": " (bta:281032)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15033446", "class_list": "", "function": "Anti-proliferative protein., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; BTG1 may play an important role in the process of angiogenesis, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D7R5;O18950;Q3SZM4", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0045766 positive regulation of angiogenesis;GO:0045603 positive regulation of endothelial cell differentiation;GO:2000271 positive regulation of fibroblast apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P53348-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53793-1", "uniprot_id": [ { "id": "SC5A3_BOVIN", "url": "https://www.uniprot.org/uniprot/P53793", "type": "external" } ], "mass": 79674.0, "length": 718, "protein_name": "Sodium/myo-inositol cotransporter", "gene_name": "SLC5A3", "organism": "Bovine", "refseq_name": "sodium/myo-inositol cotransporter", "refseq_ac": [ { "id": "NP_777032", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777032", "type": "external" } ], "gene_names_uniprotkb": "SLC5A3; SMIT", "gene_names_refseq": "SLC5A3; SMIT1; SMIT", "protein_names_uniprotkb": "Sodium/myo-inositol cotransporter; Na(+)/myo-inositol cotransporter; SMIT1; Sodium/myo-inositol transporter 1; Solute carrier family 5 member 3", "protein_names_refseq": "Na(+)/myo-inositol cotransporter; osmoregulatory Na+/myo-inositol cotransporter; sodium/myo-inositol cotransporter; sodium/myo-inositol transporter 1; solute carrier family 5 (inositol transporters), member 3; solute carrier family 5 (sodium/myo-inositol cotransporter), member 3", "tax_id": 9913, "disease": "", "pathway": " (bta:282362)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "30573663;8833264", "class_list": "", "function": "Electrogenic Na(+)-coupled sugar symporter that actively transports myo-inositol and its stereoisomer scyllo-inositol across the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1 (By similarity). Maintains myo-inositol concentration gradient that defines cell volume and fluid balance during osmotic stress, in particular in the fetoplacental unit and central nervous system (By similarity). Forms coregulatory complexes with voltage-gated K(+) ion channels, allosterically altering ion selectivity, voltage dependence and gating kinetics of the channel. In turn, K(+) efflux through the channel forms a local electrical gradient that modulates electrogenic Na(+)-coupled myo-inositol influx through the transporter (By similarity). Associates with KCNQ1-KCNE2 channel in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (By similarity). Associates with KCNQ2-KCNQ3 channel altering ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation (By similarity). Provides myo-inositol precursor for biosynthesis of phosphoinositides such as PI(4,5)P2, thus indirectly affecting the activity of phosphoinositide-dependent ion channels and Ca(2+) signaling upon osmotic stress (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005367 myo-inositol:sodium symporter activity;GO:0005412 D-glucose:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P53793-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P54228-1", "uniprot_id": [ { "id": "CTHL6_BOVIN", "url": "https://www.uniprot.org/uniprot/P54228", "type": "external" } ], "mass": 17852.0, "length": 158, "protein_name": "Cathelicidin-6", "gene_name": "CATHL6", "organism": "Bovine", "refseq_name": "cathelicidin-6 precursor", "refseq_ac": [ { "id": "NP_777257", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777257", "type": "external" } ], "gene_names_uniprotkb": "CATHL6; BMAP27", "gene_names_refseq": "CATHL6", "protein_names_uniprotkb": "Cathelicidin-6; Antibacterial peptide BMAP-27; Myeloid antibacterial peptide 27", "protein_names_refseq": "antibacterial peptide BMAP-27; antimicrobial peptide BMAP-27; cathelicidin-6 precursor; myeloid antibacterial peptide 27", "tax_id": 9913, "disease": "", "pathway": " (bta:317651)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "19136450;19845398;25966077;8910461", "class_list": "", "function": "Characterization of single nucleotide polymorphisms (SNPs) and insertion-deletion (indel) polymorphisms within the bovine CATHL gene family., [RefSeq, PubMed]; Data show that the total length of the aligned Yak cathelicidin 6 (CATHL-6) sequences was 1923 bp, including six single nucleotide polymorphisms and one indel. Publication Status: Online-Only, [RefSeq, PubMed]; Exerts a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, and fungi., [UniProtKB]; Not only a leucine zipper but also a phenylalanine zipper sequence plays an important role in maintaining the assembly of BMAP-27 on mammalian cells and the cytotoxic activity against them., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B9UKM5", "ec_number_list": [], "go_molecular_function": "GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P54228-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55206-1", "uniprot_id": [ { "id": "ANFC_BOVIN", "url": "https://www.uniprot.org/uniprot/P55206", "type": "external" } ], "mass": 13291.0, "length": 126, "protein_name": "C-type natriuretic peptide", "gene_name": "NPPC", "organism": "Bovine", "refseq_name": "C-type natriuretic peptide precursor", "refseq_ac": [ { "id": "NP_776550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776550", "type": "external" } ], "gene_names_uniprotkb": "NPPC", "gene_names_refseq": "NPPC", "protein_names_uniprotkb": "C-type natriuretic peptide; SVSP15", "protein_names_refseq": "C-type natriuretic peptide precursor; C-type natriuretic peptide; SVSP15; natriuretic peptide precursor C", "tax_id": 9913, "disease": "", "pathway": " (bta:281356); (R-BTA-5578768)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "25078681;8011167", "class_list": "", "function": "Data suggest natriuretic peptide precursor C (NPPC) can regulate oogenesis/gap junction mediated communication between oocytes and cumulus cells; here, NPPC is used in non-pharmacological coordination of meiotic prophase in vitro oocyte maturation., [RefSeq, PubMed]; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity). May also be vasoactive and natriuretic. Acts by specifically binding and stimulating NPR2 to produce cGMP. Binds the clearance receptor NPR3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4FUX3", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005179 hormone activity;GO:0051427 hormone receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0032991 protein-containing complex", "go_biological_process": "GO:0035483 gastric emptying;GO:0001525 angiogenesis;GO:0002931 response to ischemia;GO:0006182 cGMP biosynthetic process;GO:0001974 blood vessel remodeling", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P55206-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55942-1", "uniprot_id": [ { "id": "MT1H_BOVIN", "url": "https://www.uniprot.org/uniprot/P55942", "type": "external" } ], "mass": 6086.0, "length": 61, "protein_name": "Metallothionein-I, hippocampal", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Metallothionein-I, hippocampal; MT-1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8780044", "class_list": "", "function": "Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. This isoform may play a role in regulating the transport, accumulation, and compartmentation of zinc in the hippocampus., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0071276 cellular response to cadmium ion;GO:0071280 cellular response to copper ion;GO:0010273 detoxification of copper ion;GO:0006882 intracellular zinc ion homeostasis;GO:0071294 cellular response to zinc ion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P55942-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56425-1", "uniprot_id": [ { "id": "CTHL7_BOVIN", "url": "https://www.uniprot.org/uniprot/P56425", "type": "external" } ], "mass": 18848.0, "length": 165, "protein_name": "Cathelicidin-7", "gene_name": "CATHL7", "organism": "Bovine", "refseq_name": "cathelicidin-7 precursor", "refseq_ac": [ { "id": "NP_777256", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777256", "type": "external" } ], "gene_names_uniprotkb": "CATHL7; BMAP34", "gene_names_refseq": "CAMP; CATHL7", "protein_names_uniprotkb": "Cathelicidin-7; Antibacterial peptide BMAP-34", "protein_names_refseq": "antibacterial peptide BMAP-34; cathelicidin-7 precursor; cathelicidin-7", "tax_id": 9913, "disease": "", "pathway": " (bta:317650)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19136450;9409740", "class_list": "", "function": "Characterization of single nucleotide polymorphisms (SNPs) and insertion-deletion (indel) polymorphisms within the bovine CATHL gene family., [RefSeq, PubMed]; Exerts a potent antimicrobial activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QPU1;B9TUC8", "ec_number_list": [], "go_molecular_function": "GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P56425-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56451-1", "uniprot_id": [ { "id": "MC5R_BOVIN", "url": "https://www.uniprot.org/uniprot/P56451", "type": "external" } ], "mass": 36526.0, "length": 325, "protein_name": "Melanocortin receptor 5", "gene_name": "MC5R", "organism": "Bovine", "refseq_name": "melanocortin receptor 5", "refseq_ac": [ { "id": "NP_001015542", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015542", "type": "external" } ], "gene_names_uniprotkb": "MC5R", "gene_names_refseq": "MC5R; MC5", "protein_names_uniprotkb": "Melanocortin receptor 5; MC5-R", "protein_names_refseq": "MC5-R; melanocortin receptor 5", "tax_id": 9913, "disease": "", "pathway": " (bta:507987); (R-BTA-375276); (R-BTA-418555)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "G protein-coupled receptor for melanocyte-stimulating hormones (alpha- beta- and gamma-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor. Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway. Also activates ERK1/2 via a PI3K-dependent signaling mechanism. Order of potency of natural melanocortins in receptor activation is alpha-MSH > ACTH > beta-MSH > gamma-MSH (By similarity). Plays a key role in immune response, and is essential for temperature regulation and exocrine gland function (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004977 melanocortin receptor activity;GO:0004978 corticotropin receptor activity;GO:0004980 melanocyte-stimulating hormone receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0001659 temperature homeostasis;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0050777 negative regulation of immune response;GO:0045921 positive regulation of exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P56451-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56541-1", "uniprot_id": [ { "id": "DNS2A_BOVIN", "url": "https://www.uniprot.org/uniprot/P56541", "type": "external" } ], "mass": 40282.0, "length": 365, "protein_name": "Deoxyribonuclease-2-alpha", "gene_name": "DNASE2", "organism": "Bovine", "refseq_name": "deoxyribonuclease-2-alpha precursor", "refseq_ac": [ { "id": "NP_001068595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068595", "type": "external" } ], "gene_names_uniprotkb": "DNASE2; DNASE2A; DNL2", "gene_names_refseq": "DNASE2", "protein_names_uniprotkb": "Deoxyribonuclease-2-alpha; 3.1.22.1; Acid DNase; DNase II alpha; Deoxyribonuclease II alpha; Lysosomal DNase II", "protein_names_refseq": "DNase II alpha; acid DNase; deoxyribonuclease II alpha; deoxyribonuclease II, lysosomal; deoxyribonuclease-2-alpha precursor; deoxyribonuclease-2-alpha; lysosomal DNase II", "tax_id": 9913, "disease": "", "pathway": " (bta:282218)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "O46614;Q17QD1", "ec_number_list": [], "go_molecular_function": "GO:0004531 deoxyribonuclease II activity", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0043277 apoptotic cell clearance;GO:0006309 apoptotic DNA fragmentation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P56541-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58108-1", "uniprot_id": [ { "id": "AAKG1_BOVIN", "url": "https://www.uniprot.org/uniprot/P58108", "type": "external" } ], "mass": 37497.0, "length": 330, "protein_name": "5'-AMP-activated protein kinase subunit gamma-1", "gene_name": "PRKAG1", "organism": "Bovine", "refseq_name": "5'-AMP-activated protein kinase subunit gamma-1", "refseq_ac": [ { "id": "NP_777011", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777011", "type": "external" } ], "gene_names_uniprotkb": "PRKAG1", "gene_names_refseq": "PRKAG1", "protein_names_uniprotkb": "5'-AMP-activated protein kinase subunit gamma-1; AMPK gamma1; AMPK subunit gamma-1; AMPKg", "protein_names_refseq": "5'-AMP-activated protein kinase subunit gamma-1; AMP-activated protein kinase gamma 1 non-catalytic subunit; AMP-activated protein kinase subunit gamma 1 (non-catalytic subunit); AMPK gamma-1 chain; AMPK gamma1; AMPK subunit gamma-1; AMPKg", "tax_id": 9913, "disease": "", "pathway": " (bta:282324); (R-BTA-1632852); (R-BTA-380972); (R-BTA-5628897); (R-BTA-6804756); (R-BTA-9931269)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "15834636;16305752", "class_list": "", "function": "AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive., [UniProtKB, UniProtKB]; Isolation and characterization of the gene for the noncatalytic bovine gamma1 subunit of AMPK, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29RZ6", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0016208 AMP binding;GO:0043531 ADP binding;GO:0019887 protein kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031588 nucleotide-activated protein kinase complex", "go_biological_process": "GO:0006110 regulation of glycolytic process;GO:0006633 fatty acid biosynthetic process;GO:0042149 cellular response to glucose starvation;GO:0045722 positive regulation of gluconeogenesis;GO:0031669 cellular response to nutrient levels", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P58108-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58875-1", "uniprot_id": [ { "id": "S14L2_BOVIN", "url": "https://www.uniprot.org/uniprot/P58875", "type": "external" } ], "mass": 46200.0, "length": 403, "protein_name": "SEC14-like protein 2", "gene_name": "SEC14L2", "organism": "Bovine", "refseq_name": "SEC14-like protein 2", "refseq_ac": [ { "id": "NP_808812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808812", "type": "external" } ], "gene_names_uniprotkb": "SEC14L2", "gene_names_refseq": "SEC14L2", "protein_names_uniprotkb": "SEC14-like protein 2; Alpha-tocopherol-associated protein; TAP; bTAP", "protein_names_refseq": "SEC14-like 2; SEC14-like protein 2; TAP; alpha-tocopherol-associated protein; bTAP", "tax_id": 9913, "disease": "", "pathway": " (bta:282469)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10829015", "class_list": "", "function": "Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32KW6;Q867A0", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P58875-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59760-1", "uniprot_id": [ { "id": "GLYL_BOVIN", "url": "https://www.uniprot.org/uniprot/P59760", "type": "external" } ], "mass": 5574.0, "length": 49, "protein_name": "Glycolactin", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Glycolactin; 3.1.27.-", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "10486275;11105990", "class_list": "", "function": "Manifests poly C-specific RNase activity toward yeast tRNA, elicits a dose-dependent inhibition of cell-free translation, inhibits formation of superoxide ions in vitro and inhibits the hemagglutinating activities of soybean lectin and Ricinus communis agglutinin 120. Inhibits HIV-1 reverse transcriptase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0016209 antioxidant activity;GO:0004519 endonuclease activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0051607 defense response to virus;GO:0017148 negative regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P59760-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59761-1", "uniprot_id": [ { "id": "LGEN_BOVIN", "url": "https://www.uniprot.org/uniprot/P59761", "type": "external" } ], "mass": 8669.0, "length": 73, "protein_name": "Lactogenin", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Lactogenin; 3.1.27.-", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "10486275;11105990", "class_list": "", "function": "Secretory RNase specific towards pyrimidine bases, with higher activity towards poly C than poly U. Inhibits cell-free translation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0004519 endonuclease activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0050691 regulation of defense response to virus by host", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P59761-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60316-1", "uniprot_id": [ { "id": "HOOK3_BOVIN", "url": "https://www.uniprot.org/uniprot/P60316", "type": "external" } ], "mass": 1417.0, "length": 12, "protein_name": "Protein Hook homolog 3", "gene_name": "HOOK3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HOOK3", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein Hook homolog 3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "12950921", "class_list": "", "function": "(Microbial infection) Serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking., [UniProtKB, PubMed]; Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Predominantly recruits 2 dyneins, which increases both the force and speed of the microtubule motor. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034452 dynactin binding;GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005874 microtubule;GO:0070695 FHF complex", "go_biological_process": "GO:0015031 protein transport;GO:0007032 endosome organization;GO:0007040 lysosome organization;GO:0008333 endosome to lysosome transport;GO:0045022 early endosome to late endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P60316-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61257-1", "uniprot_id": [ { "id": "RL26_BOVIN", "url": "https://www.uniprot.org/uniprot/P61257", "type": "external" } ], "mass": 17258.0, "length": 145, "protein_name": "Large ribosomal subunit protein uL24", "gene_name": "RPL26", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein uL24", "refseq_ac": [ { "id": "NP_001015512", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015512", "type": "external" } ], "gene_names_uniprotkb": "RPL26", "gene_names_refseq": "RPL26", "protein_names_uniprotkb": "Large ribosomal subunit protein uL24; 60S ribosomal protein L26", "protein_names_refseq": "60S ribosomal protein L26; large ribosomal subunit protein uL24", "tax_id": 9913, "disease": "", "pathway": " (bta:337890); (R-BTA-156827); (R-BTA-1799339); (R-BTA-6791226); (R-BTA-72689); (R-BTA-72706); (R-BTA-975956); (R-BTA-975957); (R-BTA-9954709); (R-BTA-9954714); (R-BTA-9954716)", "pathway_count": 11, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PJ74;Q3T198;Q56JW1", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0031090 organelle membrane;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P61257-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61282-1", "uniprot_id": [ { "id": "NEDD8_BOVIN", "url": "https://www.uniprot.org/uniprot/P61282", "type": "external" } ], "mass": 9072.0, "length": 81, "protein_name": "Ubiquitin-like protein NEDD8", "gene_name": "NEDD8", "organism": "Bovine", "refseq_name": "ubiquitin-like protein NEDD8", "refseq_ac": [ { "id": "NP_777189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777189", "type": "external" } ], "gene_names_uniprotkb": "NEDD8", "gene_names_refseq": "NEDD8", "protein_names_uniprotkb": "Ubiquitin-like protein NEDD8; Neddylin", "protein_names_refseq": "neddylin; neural precursor cell expressed, developmentally down-regulated 8; ubiquitin-like protein NEDD8", "tax_id": 9913, "disease": "", "pathway": " (bta:286796); (R-BTA-2173789); (R-BTA-5689603); (R-BTA-8856825); (R-BTA-8951664); (R-BTA-917937)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "11118368", "class_list": "", "function": "Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53. Attachment of NEDD8 to cullins is critical for the recruitment of E2 to the cullin-RING-based E3 ubiquitin-protein ligase complex, thus facilitating polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. Attachment of NEDD8 to p53/TP53 inhibits p53/TP53 transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Neddylates EGFR resulting in protein stabilization and translocation to the cell membrane (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0P8", "ec_number_list": [], "go_molecular_function": "GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030162 regulation of proteolysis;GO:0008104 intracellular protein localization;GO:0019941 modification-dependent protein catabolic process;GO:0045116 protein neddylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P61282-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61356-1", "uniprot_id": [ { "id": "RL27_BOVIN", "url": "https://www.uniprot.org/uniprot/P61356", "type": "external" } ], "mass": 15798.0, "length": 136, "protein_name": "Large ribosomal subunit protein eL27", "gene_name": "RPL27", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein eL27", "refseq_ac": [ { "id": "NP_001029223", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029223", "type": "external" } ], "gene_names_uniprotkb": "RPL27", "gene_names_refseq": "RPL27", "protein_names_uniprotkb": "Large ribosomal subunit protein eL27; 60S ribosomal protein L27", "protein_names_refseq": "60S ribosomal protein L27; large ribosomal subunit protein eL27", "tax_id": 9913, "disease": "", "pathway": " (bta:404137); (R-BTA-156827); (R-BTA-1799339); (R-BTA-6791226); (R-BTA-72689); (R-BTA-72706); (R-BTA-975956); (R-BTA-975957); (R-BTA-9954709); (R-BTA-9954714); (R-BTA-9954716)", "pathway_count": 11, "publication_count": 1, "publication_id_list": "12658628", "class_list": "", "function": "Component of the large ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0P1", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0045202 synapse;GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0006364 rRNA processing;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P61356-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62276-1", "uniprot_id": [ { "id": "RS29_BOVIN", "url": "https://www.uniprot.org/uniprot/P62276", "type": "external" } ], "mass": 6677.0, "length": 56, "protein_name": "Small ribosomal subunit protein uS14", "gene_name": "RPS29", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein uS14", "refseq_ac": [ { "id": "NP_777229", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777229", "type": "external" } ], "gene_names_uniprotkb": "RPS29", "gene_names_refseq": "RPS29", "protein_names_uniprotkb": "Small ribosomal subunit protein uS14; 40S ribosomal protein S29", "protein_names_refseq": "40S ribosomal protein S29; small ribosomal subunit protein uS14", "tax_id": 9913, "disease": "", "pathway": " (bta:286884); (R-BTA-156827); (R-BTA-1799339); (R-BTA-6791226); (R-BTA-72649); (R-BTA-72689); (R-BTA-72695); (R-BTA-72702); (R-BTA-72706); (R-BTA-975956); (R-BTA-975957); (R-BTA-9954714); (R-BTA-9954716)", "pathway_count": 13, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P30054;Q3SZU7", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005840 ribosome;GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P62276-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62285-1", "uniprot_id": [ { "id": "ASPM_BOVIN", "url": "https://www.uniprot.org/uniprot/P62285", "type": "external" } ], "mass": 395870.0, "length": 3371, "protein_name": "Abnormal spindle-like microcephaly-associated protein homolog", "gene_name": "ASPM", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ASPM", "gene_names_refseq": "", "protein_names_uniprotkb": "Abnormal spindle-like microcephaly-associated protein homolog", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "14722158", "class_list": "", "function": "Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0097431 mitotic spindle pole", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0007051 spindle organization;GO:0051295 establishment of meiotic spindle localization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P62285-1", "record_type": "protein", "filter_code": "0000000.0000100.001000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62811-1", "uniprot_id": [ { "id": "WFD18_BOVIN", "url": "https://www.uniprot.org/uniprot/P62811", "type": "external" } ], "mass": 7787.0, "length": 74, "protein_name": "WAP four-disulfide core domain protein 18", "gene_name": "WFDC18", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "WFDC18; EXPI; WDNM1", "gene_names_refseq": "", "protein_names_uniprotkb": "WAP four-disulfide core domain protein 18; Extracellular peptidase inhibitor; Protein WDNM1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Could have proteinase inhibiting capacity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q62477", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P62811-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63214-1", "uniprot_id": [ { "id": "GBG3_BOVIN", "url": "https://www.uniprot.org/uniprot/P63214", "type": "external" } ], "mass": 8305.0, "length": 75, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3", "gene_name": "GNG3", "organism": "Bovine", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3", "refseq_ac": [ { "id": "NP_776498", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776498", "type": "external" } ], "gene_names_uniprotkb": "GNG3; GNGT3", "gene_names_refseq": "GNG3; HG3D", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3", "protein_names_refseq": "guanine nucleotide binding protein (G protein), gamma 3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3; heterotrimeric guanine nucleotide-binding protein 3D", "tax_id": 9913, "disease": "", "pathway": " (bta:281204); (R-BTA-1296041); (R-BTA-202040); (R-BTA-381676); (R-BTA-392170); (R-BTA-392451); (R-BTA-392851); (R-BTA-400042); (R-BTA-4086398); (R-BTA-416476); (R-BTA-416482); (R-BTA-418217); (R-BTA-418555); (R-BTA-418592); (R-BTA-418594); (R-BTA-418597); (R-BTA-420092); (R-BTA-428930); (R-BTA-432040); (R-BTA-456926); (R-BTA-500657); (R-BTA-6814122); (R-BTA-8964315); (R-BTA-8964616); (R-BTA-9009391); (R-BTA-9856530); (R-BTA-997272)", "pathway_count": 27, "publication_count": 2, "publication_id_list": "2122451;8276106", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P29798;Q32KX4;Q61014", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030425 dendrite;GO:0044297 cell body;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P63214-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63217-1", "uniprot_id": [ { "id": "GBG5_BOVIN", "url": "https://www.uniprot.org/uniprot/P63217", "type": "external" } ], "mass": 7318.0, "length": 68, "protein_name": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5", "gene_name": "GNG5", "organism": "Bovine", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5", "refseq_ac": [ { "id": "NP_777236", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777236", "type": "external" } ], "gene_names_uniprotkb": "GNG5; GNGT5", "gene_names_refseq": "GNG5", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5", "protein_names_refseq": "guanine nucleotide binding protein (G protein), gamma 5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5", "tax_id": 9913, "disease": "", "pathway": " (bta:287018); (R-BTA-1296041); (R-BTA-202040); (R-BTA-381676); (R-BTA-392170); (R-BTA-392451); (R-BTA-392851); (R-BTA-400042); (R-BTA-4086398); (R-BTA-416476); (R-BTA-416482); (R-BTA-418217); (R-BTA-418555); (R-BTA-418592); (R-BTA-418594); (R-BTA-418597); (R-BTA-420092); (R-BTA-428930); (R-BTA-432040); (R-BTA-456926); (R-BTA-500657); (R-BTA-6814122); (R-BTA-8964315); (R-BTA-8964616); (R-BTA-9009391); (R-BTA-9856530); (R-BTA-997272)", "pathway_count": 27, "publication_count": 2, "publication_id_list": "1549114;8352779", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P30670;Q3ZCC0;Q61015", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding", "go_cellular_component": "GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P63217-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63296-1", "uniprot_id": [ { "id": "SECR_BOVIN", "url": "https://www.uniprot.org/uniprot/P63296", "type": "external" } ], "mass": 3056.0, "length": 27, "protein_name": "Secretin", "gene_name": "SCT", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SCT", "gene_names_refseq": "", "protein_names_uniprotkb": "Secretin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7250377", "class_list": "", "function": "Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis. Exerts its biological effects by binding to secretin receptor (SCTR), a G protein-coupled receptor expressed in the basolateral domain of several cells. Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content. Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid. In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes (By similarity). Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis (By similarity). Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P01279;Q9TR13", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity;GO:0046659 digestive hormone activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0021766 hippocampus development;GO:0031667 response to nutrient levels;GO:0032098 regulation of appetite;GO:0048167 regulation of synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P63296-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79102-1", "uniprot_id": [ { "id": "CP3AS_BOVIN", "url": "https://www.uniprot.org/uniprot/P79102", "type": "external" } ], "mass": 58152.0, "length": 507, "protein_name": "Cytochrome P450 3A28", "gene_name": "CYP3A28", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CYP3A28", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 3A28; 1.14.14.1; CYPIIIA28", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "1.14.13.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.n7", "type": "external" }, { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0050649 testosterone 6-beta-hydroxylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0070989 oxidative demethylation;GO:0008202 steroid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P79102-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79113-1", "uniprot_id": [ { "id": "NPY2R_BOVIN", "url": "https://www.uniprot.org/uniprot/P79113", "type": "external" } ], "mass": 42943.0, "length": 384, "protein_name": "Neuropeptide Y receptor type 2", "gene_name": "NPY2R", "organism": "Bovine", "refseq_name": "neuropeptide Y receptor type 2", "refseq_ac": [ { "id": "NP_776826", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776826", "type": "external" } ], "gene_names_uniprotkb": "NPY2R", "gene_names_refseq": "NPY2R", "protein_names_uniprotkb": "Neuropeptide Y receptor type 2; NPY-Y2 receptor; NPY2-R; Y2 receptor", "protein_names_refseq": "NPY-Y2 receptor; NPY2-R; Y2 receptor; neuropeptide Y receptor type 2", "tax_id": 9913, "disease": "", "pathway": " (bta:281943)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for neuropeptide Y (NPY) and peptide YY (PYY). Can also bind with lower affinity pancreatic polypeptide (PP/PPY) and [Leu-31, Pro-34]NPY, an analog of NPY modified at residues 31 and 34 of the mature form. NPY or PYY binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production. Receptor activation by ligands also leads to an increase of intracellular Ca(2+) levels. Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity). As receptor for peptide PYY(3-36) in the arcuate nucleus of the hypothalamus, it is involved in the down-regulation of appetite and food intake (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001601 peptide YY receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P79113-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "G3X8C8-1", "uniprot_id": [ { "id": "G3X8C8_BOVIN", "url": "https://www.uniprot.org/uniprot/G3X8C8", "type": "external" } ], "mass": 29671.0, "length": 266, "protein_name": "Purine nucleoside phosphorylase", "gene_name": "LOC790312", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LOC790312", "gene_names_refseq": "", "protein_names_uniprotkb": "Purine nucleoside phosphorylase; 2.4.2.1; Inosine-guanosine phosphorylase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine., [UniProtKB, UniProtKB]; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "2.4.2.28", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.28", "type": "external" } ], "go_molecular_function": "GO:0004731 purine-nucleoside phosphorylase activity;GO:0047975 guanosine phosphorylase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006166 purine ribonucleoside salvage", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "G3X8C8-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MZB4-1", "uniprot_id": [ { "id": "F1MZB4_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MZB4", "type": "external" } ], "mass": 108147.0, "length": 972, "protein_name": "Peptidylglycine alpha-amidating monooxygenase", "gene_name": "PAM", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PAM", "gene_names_refseq": "", "protein_names_uniprotkb": "Peptidylglycine alpha-amidating monooxygenase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A3Q1MT65;F1MZN4", "ec_number_list": [ { "id": "1.14.17.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.17.3", "type": "external" }, { "id": "4.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.5", "type": "external" } ], "go_molecular_function": "GO:0004504 peptidylglycine monooxygenase activity;GO:0004598 peptidylamidoglycolate lyase activity;GO:0005507 copper ion binding;GO:0031418 L-ascorbic acid binding", "go_cellular_component": "GO:0030658 transport vesicle membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0001519 peptide amidation;GO:0006518 peptide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MZB4-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MZP2-1", "uniprot_id": [ { "id": "F1MZP2_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MZP2", "type": "external" } ], "mass": 43016.0, "length": 386, "protein_name": "Leupaxin", "gene_name": "LPXN", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LPXN", "gene_names_refseq": "", "protein_names_uniprotkb": "Leupaxin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0016607 nuclear speck;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0033628 regulation of cell adhesion mediated by integrin;GO:0006351 DNA-templated transcription;GO:0007155 cell adhesion;GO:0007162 negative regulation of cell adhesion;GO:0050859 negative regulation of B cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MZP2-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MZ38-1", "uniprot_id": [ { "id": "F1MZ38_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MZ38", "type": "external" } ], "mass": 36139.0, "length": 346, "protein_name": "Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial", "gene_name": "SUCLG1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SUCLG1", "gene_names_refseq": "", "protein_names_uniprotkb": "Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; 6.2.1.4; 6.2.1.5; SCS-alpha; Succinyl-CoA synthetase subunit alpha", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-71403)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. Also able to act as an itaconyl- and malyl-CoA synthetase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "6.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.5", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.9", "type": "external" } ], "go_molecular_function": "GO:0000166 nucleotide binding;GO:0004775 succinate-CoA ligase (ADP-forming) activity;GO:0004776 succinate-CoA ligase (GDP-forming) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0045244 succinate-CoA ligase complex (GDP-forming);GO:0009361 succinate-CoA ligase complex (ADP-forming)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006108 malate metabolic process;GO:0110052 toxic metabolite repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MZ38-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17870-1", "uniprot_id": [ { "id": "ARRB1_BOVIN", "url": "https://www.uniprot.org/uniprot/P17870", "type": "external" } ], "mass": 47132.0, "length": 418, "protein_name": "Beta-arrestin-1", "gene_name": "ARRB1", "organism": "Bovine", "refseq_name": "beta-arrestin-1", "refseq_ac": [ { "id": "NP_776668", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776668", "type": "external" } ], "gene_names_uniprotkb": "ARRB1", "gene_names_refseq": "ARRB1", "protein_names_uniprotkb": "Beta-arrestin-1; Arrestin beta-1; Arrestin-2", "protein_names_refseq": "arrestin-2; beta-arrestin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:281637); (R-BTA-418555); (R-BTA-432720); (R-BTA-432722); (R-BTA-456926); (R-BTA-5635838); (R-BTA-5674135); (R-BTA-5689880); (R-BTA-8856825); (R-BTA-8856828); (R-BTA-9839389)", "pathway_count": 11, "publication_count": 17, "publication_id_list": "10022830;11566136;11867621;11876640;1349018;16439357;17623778;18703513;2163110;22039220;23604253;23872075;24449856;26347956;7822302;8340388;9892661", "class_list": "", "function": "3.0 A crystal structure of the bovine arrestin-1 splice variant p44, in which the activation step is mimicked by C-tail truncation, [RefSeq, PubMed]; Conformational dynamics of helix 8 in the GPCR rhodopsin controls arrestin activation in the desensitization process, [RefSeq, PubMed]; Functions in regulating agonist-mediated G protein-coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPCR-phosphorylated receptor and sterically preclude its coupling to the cognate G protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Involved in internalization of P2RY4 and UTP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 ands subsequent recycling. Involved in the degradation of cAMP by recruiting cAMP phosphodiesterases to ligand-activated receptors. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as a signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2). ERK1/2 activated by the beta-arrestin scaffold is largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Recruits c-Src/SRC to ADRB2 resulting in ERK activation. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Inhibits ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Is required for SP-stimulated endocytosis of NK1R and recruits c-Src/SRC to internalized NK1R resulting in ERK1/2 activation, which is required for the antiapoptotic effects of SP. Is involved in proteinase-activated F2RL1-mediated ERK activity. Acts as a signaling scaffold for the AKT1 pathway. Is involved in alpha-thrombin-stimulated AKT1 signaling. Is involved in IGF1-stimulated AKT1 signaling leading to increased protection from apoptosis. Involved in activation of the p38 MAPK signaling pathway and in actin bundle formation. Involved in F2RL1-mediated cytoskeletal rearrangement and chemotaxis. Involved in AGTR1-mediated stress fiber formation by acting together with GNAQ to activate RHOA. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. May serve as nuclear messenger for GPCRs. Involved in OPRD1-stimulated transcriptional regulation by translocating to CDKN1B and FOS promoter regions and recruiting EP300 resulting in acetylation of histone H4. Involved in regulation of LEF1 transcriptional activity via interaction with DVL1 and/or DVL2 Also involved in regulation of receptors other than GPCRs. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Involved in IL8-mediated granule release in neutrophils. Binds phosphoinositides. Binds inositol hexakisphosphate (InsP6) (By similarity). Required for atypical chemokine receptor ACKR2-induced RAC1-LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Involved in the internalization of the atypical chemokine receptor ACKR3 (By similarity). Involved in smoothened (SMO) localization to primary cilium (By similarity). Negatively regulates the NOTCH signaling pathway by mediating the ubiquitination and degradation of NOTCH1 by ITCH. Participates in the recruitment of the ubiquitin-protein ligase to the receptor (By similarity). Involved in some MRGPRE-mediated signaling required to improve glucose tolerance: promotes phosphorylation of ALDOA downstream of MRGPRE activation, increasing glycolysis and leading to GLP-1 secretion (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Reduced binding of arrestin-1 to the phospho-opsin form of G90D mutant likely contributes to night blindness caused by this mutation., [RefSeq, PubMed]; The identified receptor-phospho-selective mechanism for arrestin conformation and the spacing of the multiple phosphate-binding sites in the arrestin enable arrestin to recognize plethora phosphorylation states of numerous GPCRs. Publication Status: Online-Only, [RefSeq, PubMed]; The presented functional map quantitatively connects critical interactions in the polar core and along the C tail of arrestin., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 11, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0033130 acetylcholine receptor binding;GO:0001664 G protein-coupled receptor binding;GO:0035612 AP-2 adaptor complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0006351 DNA-templated transcription;GO:0007165 signal transduction;GO:0015031 protein transport;GO:0031623 receptor internalization", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P17870-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P69341-1", "uniprot_id": [ { "id": "PARN_BOVIN", "url": "https://www.uniprot.org/uniprot/P69341", "type": "external" } ], "mass": 73182.0, "length": 638, "protein_name": "Poly(A)-specific ribonuclease PARN", "gene_name": "PARN", "organism": "Bovine", "refseq_name": "poly(A)-specific ribonuclease PARN", "refseq_ac": [ { "id": "NP_001094588", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094588", "type": "external" } ], "gene_names_uniprotkb": "PARN; DAN", "gene_names_refseq": "PARN", "protein_names_uniprotkb": "Poly(A)-specific ribonuclease PARN; 3.1.13.4; Deadenylating nuclease; Deadenylation nuclease; Polyadenylate-specific ribonuclease", "protein_names_refseq": "deadenylating nuclease; deadenylation nuclease; poly(A)-specific ribonuclease (deadenylation nuclease); poly(A)-specific ribonuclease PARN; polyadenylate-specific ribonuclease", "tax_id": 9913, "disease": "", "pathway": " (bta:524155); (R-BTA-429947); (R-BTA-450604)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10698948;9099687;9736620", "class_list": "", "function": "3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (By similarity). Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails (By similarity) (PubMed:10698948, PubMed:9736620). Also able to recognize poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QQW2", "ec_number_list": [ { "id": "3.1.13.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004535 poly(A)-specific ribonuclease activity;GO:0043169 cation binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000495 box H/ACA sno(s)RNA 3'-end processing;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening;GO:0010587 miRNA catabolic process;GO:0071051 poly(A)-dependent snoRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P69341-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26452-1", "uniprot_id": [ { "id": "RSSA_BOVIN", "url": "https://www.uniprot.org/uniprot/P26452", "type": "external" } ], "mass": 32884.0, "length": 295, "protein_name": "Small ribosomal subunit protein uS2", "gene_name": "RPSA", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein uS2", "refseq_ac": [ { "id": "NP_776804", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776804", "type": "external" } ], "gene_names_uniprotkb": "RPSA; LAMR1", "gene_names_refseq": "LAMR1; RPSA", "protein_names_uniprotkb": "Small ribosomal subunit protein uS2; 37 kDa laminin receptor precursor; 37/67 kDa laminin receptor; 37LRP; 40S ribosomal protein SA; 67 kDa laminin receptor; 67LR; LBP/p40; LRP/LR; LamR; Laminin receptor 1; Laminin-binding protein precursor p40; Protein C10", "protein_names_refseq": "37 kDa laminin receptor; 37/67 kDa laminin receptor; 37LRP; 40S ribosomal protein SA; 67 kDa laminin receptor; 67LR; LBP/p40; LRP/LR; lamR; laminin receptor 1 (ribosomal protein SA, 67 kDA); laminin-binding protein precursor p40; ribosomal protein SA pseudogene; small ribosomal subunit protein uS2", "tax_id": 9913, "disease": "", "pathway": " (bta:281898); (R-BTA-156827); (R-BTA-1799339); (R-BTA-6791226); (R-BTA-72649); (R-BTA-72689); (R-BTA-72695); (R-BTA-72702); (R-BTA-72706); (R-BTA-975956); (R-BTA-975957); (R-BTA-9954714); (R-BTA-9954716)", "pathway_count": 13, "publication_count": 1, "publication_id_list": "1849001", "class_list": "", "function": "Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZCE4", "ec_number_list": [], "go_molecular_function": "GO:0043236 laminin binding;GO:0005055 laminin receptor activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000028 ribosomal small subunit assembly;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P26452-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61287-1", "uniprot_id": [ { "id": "PP1G_BOVIN", "url": "https://www.uniprot.org/uniprot/P61287", "type": "external" } ], "mass": 36984.0, "length": 323, "protein_name": "Serine/threonine-protein phosphatase PP1-gamma catalytic subunit", "gene_name": "PPP1CC", "organism": "Bovine", "refseq_name": "serine/threonine-protein phosphatase PP1-gamma catalytic subunit", "refseq_ac": [ { "id": "NP_777006", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777006", "type": "external" } ], "gene_names_uniprotkb": "PPP1CC", "gene_names_refseq": "PPP1CC", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase PP1-gamma catalytic subunit; 3.1.3.16; PP-1G; Protein phosphatase 1C catalytic subunit", "protein_names_refseq": "PP-1G; protein phosphatase 1C catalytic subunit; serine/threonine-protein phosphatase PP1-gamma catalytic subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:282318); (R-BTA-141430); (R-BTA-141444); (R-BTA-2467813); (R-BTA-2500257); (R-BTA-5663220); (R-BTA-5673000); (R-BTA-9648025)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "12065625", "class_list": "", "function": "Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Regulates the recruitment of the SKA complex to kinetochores (By similarity). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (By similarity). Dephosphorylates MKI67 at the onset of anaphase (By similarity). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (By similarity). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q08DZ0", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0016791 phosphatase activity;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0016607 nuclear speck", "go_biological_process": "GO:0051301 cell division;GO:0005977 glycogen metabolic process;GO:0030182 neuron differentiation;GO:0042752 regulation of circadian rhythm;GO:0006470 protein dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P61287-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P45879-1", "uniprot_id": [ { "id": "VDAC1_BOVIN", "url": "https://www.uniprot.org/uniprot/P45879", "type": "external" } ], "mass": 30741.0, "length": 283, "protein_name": "Non-selective voltage-gated ion channel VDAC1", "gene_name": "VDAC1", "organism": "Bovine", "refseq_name": "non-selective voltage-gated ion channel VDAC1", "refseq_ac": [ { "id": "NP_776910", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776910", "type": "external" } ], "gene_names_uniprotkb": "VDAC1", "gene_names_refseq": "VDAC1", "protein_names_uniprotkb": "Non-selective voltage-gated ion channel VDAC1; BR1-VDAC; Brain-derived voltage-dependent anion channel 1; Plasmalemmal porin; VDAC-1; Voltage-dependent anion-selective channel protein 1", "protein_names_refseq": "BR1-VDAC; VDAC-1; brain-derived voltage-dependent anion channel 1; non-selective voltage-gated ion channel VDAC1; plasmalemmal porin; voltage-dependent anion-selective channel protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:282119); (R-BTA-5205685); (R-BTA-5689880); (R-BTA-70268)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10527528;17647012;19688190;7507248;7685355", "class_list": "", "function": "Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol. In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. May mediate ATP export from cells (By similarity). Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix (By similarity). Mediates cytochrome c efflux (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results describe the expression of voltage-dependent anion channel isoforms in rat, bovine, and chicken brain mitochondria, and suggest that the nature of hexokinase binding site is not determined by the expression of a single VDAC isoform. GeneRIF: Multiple spots on 2D gel representing VDAC1 protein forms with different isoelectric points., [RefSeq, PubMed]; Suggest that VDAC1 participates in volume regulatory processes in spermatozoa., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZCK0;Q71SW7", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0008142 oxysterol binding;GO:0005524 ATP binding;GO:0005244 voltage-gated monoatomic ion channel activity;GO:0015288 porin activity;GO:0008308 voltage-gated monoatomic anion channel activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0006869 lipid transport;GO:0006915 apoptotic process;GO:0036444 calcium import into the mitochondrion;GO:0006820 monoatomic anion transport;GO:0030855 epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P45879-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12820-1", "uniprot_id": [ { "id": "ACE_BOVIN", "url": "https://www.uniprot.org/uniprot/P12820", "type": "external" } ], "mass": 150097.0, "length": 1306, "protein_name": "Angiotensin-converting enzyme", "gene_name": "ACE", "organism": "Bovine", "refseq_name": "angiotensin-converting enzyme precursor", "refseq_ac": [ { "id": "NP_001193597", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193597", "type": "external" } ], "gene_names_uniprotkb": "ACE; DCP1", "gene_names_refseq": "ACE", "protein_names_uniprotkb": "Angiotensin-converting enzyme; 3.4.15.1; ACE; Dipeptidyl carboxypeptidase I; Kininase II", "protein_names_refseq": "angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin-converting enzyme precursor; dipeptidyl carboxypeptidase I; kininase II", "tax_id": 9913, "disease": "", "pathway": " (bta:509484); (R-BTA-2022377)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12935891;18577431;19393038;28244620;2835538;3028395", "class_list": "", "function": "A portion of the extracellular region of tACE (containing its catalytic site) is released from bovine sperm during capacitation, and tACE activity may be required for sperm capacitation., [RefSeq, PubMed]; Dipeptidyl carboxypeptidase that removes dipeptides from the C-terminus of a variety of circulating hormones, such as angiotensin I, bradykinin or enkephalins, thereby playing a key role in the regulation of blood pressure, electrolyte homeostasis or synaptic plasticity. Composed of two similar catalytic domains, each possessing a functional active site, with different selectivity for substrates. Plays a major role in the angiotensin-renin system that regulates blood pressure and sodium retention by the kidney by converting angiotensin I to angiotensin II, resulting in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator, and therefore enhance the blood pressure response. Acts as a regulator of synaptic transmission by mediating cleavage of neuropeptide hormones, such as substance P, neurotensin or enkephalins. Catalyzes degradation of different enkephalin neuropeptides (Met-enkephalin, Leu-enkephalin, Met-enkephalin-Arg-Phe and possibly Met-enkephalin-Arg-Gly-Leu) (By similarity). Acts as a regulator of synaptic plasticity in the nucleus accumbens of the brain by mediating cleavage of Met-enkephalin-Arg-Phe, a strong ligand of Mu-type opioid receptor OPRM1, into Met-enkephalin. Met-enkephalin-Arg-Phe cleavage by ACE decreases activation of OPRM1, leading to long-term synaptic potentiation of glutamate release (By similarity). Also acts as a regulator of hematopoietic stem cell differentiation by mediating degradation of hemoregulatory peptide N-acetyl-SDKP (AcSDKP). Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1. Involved in amyloid-beta metabolism by catalyzing degradation of Amyloid-beta protein 40 and Amyloid-beta protein 42 peptides, thereby preventing plaque formation. Catalyzes cleavage of cholecystokinin (maturation of Cholecystokinin-8 and Cholecystokinin-5) and Gonadoliberin-1 (both maturation and degradation) hormones. Degradation of hemoregulatory peptide N-acetyl-SDKP (AcSDKP) and amyloid-beta proteins is mediated by the N-terminal catalytic domain, while angiotensin I and cholecystokinin cleavage is mediated by the C-terminal catalytic region (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Phorbol 12-myristate 13-acetate (PMA) induced Egr-1 and ATF-2 binding to the ACE promoter, whereas Ets-1 binding was suppressed by PMA., [RefSeq, PubMed]; Soluble form that is released in blood plasma and other body fluids following proteolytic cleavage in the juxtamembrane stalk region., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The results indicate that the two active sites within bovine somatic ACE exhibit strong negative cooperativity., [RefSeq, PubMed]", "predicted_glycosites": 16, "predicted_n_glycosites": 16, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 16, "binding_glycan_count": 0, "secondary_ac_list": "F1MQJ0;Q0GA41", "ec_number_list": [ { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "3.4.15.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.15.1", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0005516 calmodulin binding;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0008240 tripeptidyl-peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0005764 lysosome", "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0050435 amyloid-beta metabolic process;GO:0001822 kidney development;GO:0002003 angiotensin maturation;GO:0003084 positive regulation of systemic arterial blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P12820-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIE2-1", "uniprot_id": [ { "id": "SHC1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIE2", "type": "external" } ], "mass": 51631.0, "length": 473, "protein_name": "SHC-transforming protein 1", "gene_name": "SHC1", "organism": "Bovine", "refseq_name": "SHC-transforming protein 1 isoform a", "refseq_ac": [ { "id": "NP_001157533", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157533", "type": "external" } ], "gene_names_uniprotkb": "SHC1", "gene_names_refseq": "SHC1; p66shc", "protein_names_uniprotkb": "SHC-transforming protein 1; SH2 domain protein C1; Src homology 2 domain-containing-transforming protein C1", "protein_names_refseq": "SH2 domain protein C1; SHC (Src homology 2 domain containing) transforming protein 1; SHC-transforming protein 1 isoform a; SHC-transforming protein 1; src homology 2 domain-containing-transforming protein C1", "tax_id": 9913, "disease": "", "pathway": " (bta:507196); (R-BTA-1250196); (R-BTA-1250347); (R-BTA-167044); (R-BTA-180336); (R-BTA-201556); (R-BTA-210993); (R-BTA-2424491); (R-BTA-2428933); (R-BTA-2730905); (R-BTA-2871796); (R-BTA-2871809); (R-BTA-354192); (R-BTA-512988); (R-BTA-5654688); (R-BTA-5654699); (R-BTA-5654704); (R-BTA-5654719); (R-BTA-5673001); (R-BTA-74749); (R-BTA-74751); (R-BTA-8851805); (R-BTA-8853659); (R-BTA-8983432); (R-BTA-9009391); (R-BTA-9020558); (R-BTA-9027284); (R-BTA-912526); (R-BTA-9634597); (R-BTA-9674555)", "pathway_count": 30, "publication_count": 6, "publication_id_list": "17382201;18047664;18606845;23109234;24475205;31323685", "class_list": "", "function": "High-intensity interval training modulates retinal microvascular phenotype and DNA methylation of p66Shc gene: a randomized controlled trial (EXAMIN AGE)., [RefSeq, PubMed]; P66Shc is involved in the regulation of embryo development specifically in mediating early cleavage arrest and facilitating development to the blastocyst stage for in vitro produced bovine embryos Publication Status: Online-Only, [RefSeq, PubMed]; P66shc, but not p53, is significantly more abundant in an embryo population that exhibits higher frequencies of embryo arrest., [RefSeq, PubMed]; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). Involved in the oncostatin-M-mediated signaling pathway through type II OSM receptor complex (heterodimers composed of OSMR and IL6ST) where it contributes to activation of the Ras/Raf/MAPK pathway through JAK1-dependent recruitment to OSMR subunit of OSMR complex and SHC1 association with GRB2 (By similarity)., [UniProtKB, UniProtKB]; Studied p66Shc levels, redox state, and developmental potential in early bovine embryos. p66Shc content was increased by either high (20%) O(2) culture or H(2)O(2) treatment, and significantly dec'd by antioxidant polyethylene glycol-conjugated catalase., [RefSeq, PubMed]; The p66(Shc) adaptor protein controls oxidative stress response in early bovine embryos. Publication Status: Online-Only, [RefSeq, PubMed]; These results support a model in which Shc orchestrates signals from cell-cell and cell-matrix adhesions to elicit flow-induced inflammatory signaling., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q45KX9", "ec_number_list": [], "go_molecular_function": "GO:0030971 receptor tyrosine kinase binding;GO:0001784 phosphotyrosine residue binding;GO:0005158 insulin receptor binding;GO:0046875 ephrin receptor binding;GO:0005159 insulin-like growth factor receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0005829 cytosol", "go_biological_process": "GO:0001525 angiogenesis;GO:0035556 intracellular signal transduction;GO:0071363 cellular response to growth factor stimulus;GO:0007173 epidermal growth factor receptor signaling pathway;GO:0008286 insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q0IIE2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DI1-1", "uniprot_id": [ { "id": "ETAA1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DI1", "type": "external" } ], "mass": 99859.0, "length": 899, "protein_name": "Ewing's tumor-associated antigen 1 homolog", "gene_name": "ETAA1", "organism": "Bovine", "refseq_name": "ewing's tumor-associated antigen 1 homolog", "refseq_ac": [ { "id": "NP_001068596", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068596", "type": "external" } ], "gene_names_uniprotkb": "ETAA1", "gene_names_refseq": "ETAA16; ETAA1", "protein_names_uniprotkb": "Ewing's tumor-associated antigen 1 homolog", "protein_names_refseq": "ETAA1, ATR kinase activator; Ewing tumor associated antigen 1; ewing's tumor-associated antigen 1 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:282224)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity. Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1. Probably only regulates a subset of ATR targets., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0016607 nuclear speck", "go_biological_process": "GO:2000001 regulation of DNA damage checkpoint;GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0071902 positive regulation of protein serine/threonine kinase activity;GO:0031297 replication fork processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DI1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79134-1", "uniprot_id": [ { "id": "ANXA6_BOVIN", "url": "https://www.uniprot.org/uniprot/P79134", "type": "external" } ], "mass": 75907.0, "length": 673, "protein_name": "Annexin A6", "gene_name": "ANXA6", "organism": "Bovine", "refseq_name": "annexin A6", "refseq_ac": [ { "id": "NP_001096694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096694", "type": "external" } ], "gene_names_uniprotkb": "ANXA6; ANX6", "gene_names_refseq": "ANXA6", "protein_names_uniprotkb": "Annexin A6; Annexin VI; Annexin-6", "protein_names_refseq": "annexin A6; annexin VI; annexin-6", "tax_id": 9913, "disease": "", "pathway": " (bta:327685)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18597635;21672540;9748523", "class_list": "", "function": "AnxA6 is a novel receptor that mediates the endocytosis of bovine beta-glucuronidase., [RefSeq, PubMed]; May associate with CD21. May regulate the release of Ca(2+) from intracellular stores., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The results showed that alkaline phosphatase activity was significantly increased in matrix vesicles from calcified bovine vascular smooth muscle cells (BVSMCs) compared with noncalcified BVSMCs, as was annexin II and VI content and (45)Ca uptake., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7YY61", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0008201 heparin binding;GO:0019899 enzyme binding;GO:0048306 calcium-dependent protein binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0016020 membrane", "go_biological_process": "GO:0006816 calcium ion transport;GO:0097190 apoptotic signaling pathway;GO:0031214 biomineral tissue development;GO:0070588 calcium ion transmembrane transport;GO:0003418 growth plate cartilage chondrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P79134-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P57695-1", "uniprot_id": [ { "id": "GLRA1_BOVIN", "url": "https://www.uniprot.org/uniprot/P57695", "type": "external" } ], "mass": 52614.0, "length": 457, "protein_name": "Glycine receptor subunit alpha-1", "gene_name": "GLRA1; GLRA2", "organism": "Bovine", "refseq_name": "glycine receptor subunit alpha-1 precursor", "refseq_ac": [ { "id": "NP_776746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776746", "type": "external" } ], "gene_names_uniprotkb": "GLRA1; GLRA2; GLRA2", "gene_names_refseq": "GLRA1", "protein_names_uniprotkb": "Glycine receptor subunit alpha-1; Glycine receptor 48 kDa subunit; Glycine receptor strychnine-binding subunit", "protein_names_refseq": "glycine receptor 48 kDa subunit; glycine receptor alpha 1 subunit; glycine receptor strychnine-binding subunit; glycine receptor subunit alpha-1 precursor; glycine receptor subunit alpha-1; glycine receptor, alpha 1 (startle disease/hyperekplexia); glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome)", "tax_id": 9913, "disease": "", "pathway": " (bta:281783); (bta:537660); (R-BTA-112314)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "11178872", "class_list": "", "function": "Subunit of heteromeric glycine-gated chloride channels (PubMed:11178872). Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:11178872). Channel activity is potentiated by ethanol (By similarity). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9GKE9;Q9GKF0", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0016934 extracellularly glycine-gated chloride channel activity;GO:0030977 taurine binding;GO:0004888 transmembrane signaling receptor activity;GO:0008270 zinc ion binding;GO:0016594 glycine binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043204 perikaryon;GO:0043231 intracellular membrane-bounded organelle", "go_biological_process": "GO:2000344 positive regulation of acrosome reaction;GO:0001964 startle response;GO:0051970 negative regulation of transmission of nerve impulse;GO:0060012 synaptic transmission, glycinergic;GO:0097305 response to alcohol", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P57695-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07926-1", "uniprot_id": [ { "id": "AT5G2_BOVIN", "url": "https://www.uniprot.org/uniprot/P07926", "type": "external" } ], "mass": 15029.0, "length": 143, "protein_name": "ATP synthase F(0) complex subunit C2, mitochondrial", "gene_name": "ATP5MC2", "organism": "Bovine", "refseq_name": "ATP synthase F(0) complex subunit C2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_788786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788786", "type": "external" } ], "gene_names_uniprotkb": "ATP5MC2; ATP5G2", "gene_names_refseq": "ATP5G2; ATP5MC2", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit C2, mitochondrial; ATP synthase lipid-binding protein; ATP synthase membrane subunit c locus 2; ATP synthase proteolipid P2; ATPase protein 9; ATPase subunit c", "protein_names_refseq": "ATP synthase F(0) complex subunit C2, mitochondrial precursor; ATP synthase F(0) complex subunit C2, mitochondrial; ATP synthase lipid-binding protein, mitochondrial; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9); ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9); ATP synthase, H+ transporting, mitochondrial Fo complex subunit C2 (subunit 9); ATPase protein 9; ATPase subunit c; mit-ATP synthase proteolipid P2 subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:337887); (R-BTA-1268020); (R-BTA-163210); (R-BTA-8949613)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "12658628;1827992;1829867;2549952;2868890", "class_list": "", "function": "Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P00839;Q54A29", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0045259 proton-transporting ATP synthase complex;GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P07926-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05B84-1", "uniprot_id": [ { "id": "FSD1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05B84", "type": "external" } ], "mass": 55720.0, "length": 496, "protein_name": "Fibronectin type III and SPRY domain-containing protein 1", "gene_name": "FSD1", "organism": "Bovine", "refseq_name": "fibronectin type III and SPRY domain-containing protein 1", "refseq_ac": [ { "id": "NP_001074987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074987", "type": "external" } ], "gene_names_uniprotkb": "FSD1", "gene_names_refseq": "FSD1", "protein_names_uniprotkb": "Fibronectin type III and SPRY domain-containing protein 1", "protein_names_refseq": "fibronectin type III and SPRY domain-containing protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:510595)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in microtubule organization and stabilization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005874 microtubule;GO:0032154 cleavage furrow", "go_biological_process": "GO:0051301 cell division;GO:0060236 regulation of mitotic spindle organization;GO:0051302 regulation of cell division;GO:0032465 regulation of cytokinesis;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q05B84-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIG8-1", "uniprot_id": [ { "id": "RAB18_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIG8", "type": "external" } ], "mass": 22991.0, "length": 206, "protein_name": "Ras-related protein Rab-18", "gene_name": "RAB18", "organism": "Bovine", "refseq_name": "ras-related protein Rab-18", "refseq_ac": [ { "id": "NP_001068967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068967", "type": "external" } ], "gene_names_uniprotkb": "RAB18", "gene_names_refseq": "RAB18", "protein_names_uniprotkb": "Ras-related protein Rab-18; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-18", "tax_id": 9913, "disease": "", "pathway": " (bta:511160); (R-BTA-6798695); (R-BTA-6811436); (R-BTA-8873719); (R-BTA-8876198)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB18 is required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (By similarity). Also required for maintaining endoplasmic reticulum structure (By similarity). Plays a role in apical endocytosis/recycling (By similarity). Plays a key role in eye and brain development and neurodegeneration (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane;GO:0016324 apical plasma membrane;GO:0033106 cis-Golgi network membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0015031 protein transport;GO:0007420 brain development;GO:0016192 vesicle-mediated transport;GO:0001654 eye development;GO:0006886 intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0IIG8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38573-1", "uniprot_id": [ { "id": "UPK1B_BOVIN", "url": "https://www.uniprot.org/uniprot/P38573", "type": "external" } ], "mass": 29730.0, "length": 260, "protein_name": "Uroplakin-1b", "gene_name": "UPK1B", "organism": "Bovine", "refseq_name": "uroplakin-1b", "refseq_ac": [ { "id": "NP_776907", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776907", "type": "external" } ], "gene_names_uniprotkb": "UPK1B", "gene_names_refseq": "UPK1B", "protein_names_uniprotkb": "Uroplakin-1b; UP1b; UPIb; Uroplakin Ib", "protein_names_refseq": "UP1b; UPIb; uroplakin IB; uroplakin-1b", "tax_id": 9913, "disease": "", "pathway": " (bta:282113)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12446744;12475947;8138569", "class_list": "", "function": "Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1LZG4", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0120001 apical plasma membrane urothelial plaque;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0034394 protein localization to cell surface;GO:0030855 epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P38573-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38447-1", "uniprot_id": [ { "id": "NUCG_BOVIN", "url": "https://www.uniprot.org/uniprot/P38447", "type": "external" } ], "mass": 32262.0, "length": 299, "protein_name": "Endonuclease G, mitochondrial", "gene_name": "ENDOG", "organism": "Bovine", "refseq_name": "endonuclease G, mitochondrial precursor", "refseq_ac": [ { "id": "NP_787017", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787017", "type": "external" } ], "gene_names_uniprotkb": "ENDOG", "gene_names_refseq": "ENDOG", "protein_names_uniprotkb": "Endonuclease G, mitochondrial; 3.1.30.-; Endo G", "protein_names_refseq": "endo G; endonuclease G, mitochondrial precursor; endonuclease G, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:327707)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15066427;3360771;7688144;7870594", "class_list": "", "function": "Endonuclease that preferentially catalyzes the cleavage of double-stranded 5-hydroxymethylcytosine (5hmC)-modified DNA (By similarity). The 5hmC-modified nucleotide does not increase the binding affinity, but instead increases the efficiency of cutting and specifies the site of cleavage for the modified DNAs (By similarity). Shows significantly higher affinity for four- stranded Holliday junction over duplex and single-stranded DNAs (By similarity). Promotes conservative recombination when the DNA is 5hmC-modified (By similarity). Promotes autophagy through the suppression of mTOR by its phosphorylation-mediated interaction with YWHAG and its endonuclease activity-mediated DNA damage response (By similarity). GSK3-beta mediated phosphorylation of ENDOG enhances its interaction with YWHAG, leading to the release of TSC2 and PIK3C3 from YWHAG resulting in mTOR pathway suppression and autophagy initiation (By similarity). Promotes cleavage of mtDNA in response to oxidative and nitrosative stress, in turn inducing compensatory mtDNA replication (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results describe the mechanism of catalysis and substrate binding by the apoptotic mitochondrial nuclease EndoG, which belongs to the large family of DNA/RNA non-specific betabetaalpha-Me-finger nucleases., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4IFL3", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042803 protein homodimerization activity;GO:0003676 nucleic acid binding;GO:0004520 DNA endonuclease activity;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0090297 positive regulation of mitochondrial DNA replication;GO:0006974 DNA damage response;GO:0010508 positive regulation of autophagy;GO:0032007 negative regulation of TOR signaling;GO:0006309 apoptotic DNA fragmentation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P38447-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81127-1", "uniprot_id": [ { "id": "SNAG_BOVIN", "url": "https://www.uniprot.org/uniprot/P81127", "type": "external" } ], "mass": 34636.0, "length": 312, "protein_name": "Gamma-soluble NSF attachment protein", "gene_name": "NAPG", "organism": "Bovine", "refseq_name": "gamma-soluble NSF attachment protein", "refseq_ac": [ { "id": "NP_001039487", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039487", "type": "external" } ], "gene_names_uniprotkb": "NAPG; SNAPG", "gene_names_refseq": "NAPG", "protein_names_uniprotkb": "Gamma-soluble NSF attachment protein; N-ethylmaleimide-sensitive factor attachment protein gamma; SNAP-gamma", "protein_names_refseq": "N-ethylmaleimide-sensitive factor attachment protein, gamma; SNAP-gamma; gamma-soluble NSF attachment protein", "tax_id": 9913, "disease": "", "pathway": " (bta:509041); (R-BTA-204005); (R-BTA-6807878); (R-BTA-6811434); (R-BTA-6811438); (R-BTA-6811440)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "8455721", "class_list": "", "function": "Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29RL7", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0005483 soluble NSF attachment protein activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0031201 SNARE complex;GO:0005739 mitochondrion;GO:0005886 plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P81127-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DP0-1", "uniprot_id": [ { "id": "PGM1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DP0", "type": "external" } ], "mass": 61589.0, "length": 562, "protein_name": "Phosphoglucomutase-1", "gene_name": "PGM1", "organism": "Bovine", "refseq_name": "phosphoglucomutase-1", "refseq_ac": [ { "id": "NP_001070371", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070371", "type": "external" } ], "gene_names_uniprotkb": "PGM1", "gene_names_refseq": "PGM1", "protein_names_uniprotkb": "Phosphoglucomutase-1; 5.4.2.2; Glucose phosphomutase 1; PGM 1", "protein_names_refseq": "PGM 1; glucose phosphomutase 1; phosphoglucomutase-1", "tax_id": 9913, "disease": "", "pathway": " (bta:534402)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate (By similarity). The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate (By similarity). This enzyme participates in both the breakdown and synthesis of glucose (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004614 phosphoglucomutase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006006 glucose metabolic process;GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DP0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5H7-1", "uniprot_id": [ { "id": "SYRM_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5H7", "type": "external" } ], "mass": 65631.0, "length": 578, "protein_name": "Probable arginine--tRNA ligase, mitochondrial", "gene_name": "RARS2", "organism": "Bovine", "refseq_name": "probable arginine--tRNA ligase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001069346", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069346", "type": "external" } ], "gene_names_uniprotkb": "RARS2; RARSL", "gene_names_refseq": "RARS2", "protein_names_uniprotkb": "Probable arginine--tRNA ligase, mitochondrial; 6.1.1.19; ArgRS; Arginyl-tRNA synthetase", "protein_names_refseq": "argRS; arginine--tRNA ligase; probable arginine--tRNA ligase, mitochondrial precursor; probable arginine--tRNA ligase, mitochondrial; probable arginyl-tRNA synthetase, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:525894)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the attachment of arginine to tRNA(Arg) in a two-step reaction: arginine is first activated by ATP to form Arg-AMP and then transferred to the acceptor end of tRNA(Arg)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.19", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004814 arginine-tRNA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0006420 arginyl-tRNA aminoacylation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5H7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DQ0-1", "uniprot_id": [ { "id": "PKP3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DQ0", "type": "external" } ], "mass": 86529.0, "length": 793, "protein_name": "Plakophilin-3", "gene_name": "PKP3", "organism": "Bovine", "refseq_name": "plakophilin-3", "refseq_ac": [ { "id": "NP_001070326", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070326", "type": "external" } ], "gene_names_uniprotkb": "PKP3", "gene_names_refseq": "PKP3", "protein_names_uniprotkb": "Plakophilin-3", "protein_names_refseq": "plakophilin-3", "tax_id": 9913, "disease": "", "pathway": " (bta:516247)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Required for the localization of DSG2, DSP and PKP2 to mature desmosome junctions (By similarity). May also play a role in the maintenance of DSG3 protein abundance in keratinocytes (By similarity). Required for the formation of DSP-containing desmosome precursors in the cytoplasm during desmosome assembly (By similarity). Also regulates the accumulation of CDH1 to mature desmosome junctions, via cAMP-dependent signaling and its interaction with activated RAP1A (By similarity). Positively regulates the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with FXR1, may also regulate the protein abundance of DSP via the same mechanism (By similarity). May also regulate the protein abundance of the desmosome component PKP1 (By similarity). Required for the organization of desmosome junctions at intercellular borders between basal keratinocytes of the epidermis, as a result plays a role in maintenance of the dermal barrier and regulation of the dermal inflammatory response (By similarity). Required during epidermal keratinocyte differentiation for cell adherence at tricellular cell-cell contacts, via regulation of the timely formation of adherens junctions and desmosomes in a calcium-dependent manner, and may also play a role in the organization of the intracellular actin fiber belt (By similarity). Acts as a negative regulator of the inflammatory response in hematopoietic cells of the skin and intestine, via modulation of proinflammatory cytokine production (By similarity). Important for epithelial barrier maintenance in the intestine to reduce intestinal permeability, thereby plays a role in protection from intestinal-derived endotoxemia (By similarity). Required for the development of hair follicles, via a role in the regulation of inner root sheaf length, correct alignment and anterior-posterior polarity of hair follicles (By similarity). Promotes proliferation and cell-cycle G1/S phase transition of keratinocytes (By similarity). Promotes E2F1-driven transcription of G1/S phase promoting genes by acting to release E2F1 from its inhibitory interaction with RB1, via sequestering RB1 and CDKN1A to the cytoplasm and thereby increasing CDK4- and CDK6-driven phosphorylation of RB1 (By similarity). May act as a scaffold protein to facilitate MAPK phosphorylation of RPS6KA protein family members and subsequently promote downstream EGFR signaling (By similarity). May play a role in the positive regulation of transcription of Wnt-mediated TCF-responsive target genes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0045296 cadherin binding;GO:0019899 enzyme binding;GO:0050839 cell adhesion molecule binding;GO:0045294 alpha-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0002718 regulation of cytokine production involved in immune response;GO:0045785 positive regulation of cell adhesion;GO:0030036 actin cytoskeleton organization;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DQ0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DP1-1", "uniprot_id": [ { "id": "TM10B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DP1", "type": "external" } ], "mass": 36652.0, "length": 316, "protein_name": "tRNA methyltransferase 10 homolog B", "gene_name": "TRMT10B", "organism": "Bovine", "refseq_name": "tRNA methyltransferase 10 homolog B", "refseq_ac": [ { "id": "NP_001070327", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070327", "type": "external" } ], "gene_names_uniprotkb": "TRMT10B; RG9MTD3", "gene_names_refseq": "RG9MTD3; TRMT10B", "protein_names_uniprotkb": "tRNA methyltransferase 10 homolog B; 2.1.1.221; RNA (guanine-9-)-methyltransferase domain-containing protein 3; tRNA (guanine(9)-N(1))-methyltransferase TRMT10B", "protein_names_refseq": "RNA (guanine-9-) methyltransferase domain containing 3; RNA (guanine-9-)-methyltransferase domain-containing protein 3; tRNA (guanine(9)-N(1))-methyltransferase TRMT10B; tRNA methyltransferase 10 homolog B", "tax_id": 9913, "disease": "", "pathway": " (bta:516258)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.221", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.221", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.218", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.218", "type": "external" } ], "go_molecular_function": "GO:0000049 tRNA binding;GO:0052905 tRNA (guanosine(9)-N1)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol", "go_biological_process": "GO:0002939 tRNA N1-guanine methylation;GO:0032259 methylation;GO:0045039 protein insertion into mitochondrial inner membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DP1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08E40-1", "uniprot_id": [ { "id": "S39AC_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08E40", "type": "external" } ], "mass": 72783.0, "length": 654, "protein_name": "Zinc transporter ZIP12", "gene_name": "SLC39A12", "organism": "Bovine", "refseq_name": "zinc transporter ZIP12 precursor", "refseq_ac": [ { "id": "NP_001070346", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070346", "type": "external" } ], "gene_names_uniprotkb": "SLC39A12; ZIP12", "gene_names_refseq": "SLC39A12", "protein_names_uniprotkb": "Zinc transporter ZIP12; Solute carrier family 39 member 12; ZIP-12; Zrt- and Irt-like protein 12", "protein_names_refseq": "ZIP-12; solute carrier family 39 (zinc transporter), member 12; zinc transporter ZIP12 precursor; zinc transporter ZIP12; zrt- and Irt-like protein 12", "tax_id": 9913, "disease": "", "pathway": " (bta:527210)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Uniporter that promotes Zn(2+) import from the extracellular space to the cytoplasm across the cell membrane. The transport activity is temperature dependent. May play a role in neurulation and neurite extension. May play a key role in maintaining intracellular zinc content at levels that reduce the inhibitory effects of rises in oxidative stress on spermatogonia and spermatozoa viability during spermatogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0140410 monoatomic cation:bicarbonate symporter activity;GO:0046873 metal ion transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0030003 intracellular monoatomic cation homeostasis;GO:0071578 zinc ion import across plasma membrane;GO:1990138 neuron projection extension;GO:0001841 neural tube formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08E40-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07455-1", "uniprot_id": [ { "id": "IGF1_BOVIN", "url": "https://www.uniprot.org/uniprot/P07455", "type": "external" } ], "mass": 17066.0, "length": 154, "protein_name": "Insulin-like growth factor 1", "gene_name": "IGF1", "organism": "Bovine", "refseq_name": "insulin-like growth factor 1 preproprotein", "refseq_ac": [ { "id": "NP_001071296", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071296", "type": "external" } ], "gene_names_uniprotkb": "IGF1; IGF-1", "gene_names_refseq": "IGF-1; IGF-I; IGF1", "protein_names_uniprotkb": "Insulin-like growth factor 1; IGF-I; Insulin-like growth factor I; Somatomedin", "protein_names_refseq": "class 1 insulin-like growth factor I preproprotein; insulin growth factor-1; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1 preproprotein; insulin-like growth factor I (somatomedin C); prepro-IGF-I", "tax_id": 9913, "disease": "", "pathway": " (bta:281239); (R-BTA-114608); (R-BTA-2404192); (R-BTA-2428928); (R-BTA-2428933); (R-BTA-381426); (R-BTA-422085)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "2308858;31468638;31785637;3390164;34364639;34626867;37230145;3941093;7867698", "class_list": "", "function": "Components of the insulin-like growth factor system in in vivo - and in vitro-derived fetuses of cattle, and the association with growth and development., [RefSeq, PubMed]; Insulin-like growth factor-1 induces IRE1-XBP1-dependent endoplasmic reticulum biogenesis in bovine mammary epithelial cells., [RefSeq, PubMed]; The addition of PAPP-A did not affect embryo yield and blastocyst survival, higher IGF-1 levels may affect embryo competence through differential expression of genes involved in lipid metabolism, oocyte competence, and mitochondrial function., [RefSeq, PubMed]; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity). As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This study showed that the IGF-1 SnaBI TT appears to be associated with fewer days to ovulation and lesser calving to conseption interval of lactating dairy cows and had an additive association with the GHR AluI T allele on indicators for improvement of fertility., [RefSeq, PubMed]; [The lipidosis of the liver of dairy cows: Part 1 - Role of insulin and the Growth Hormone-IGF-1 axis]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005159 insulin-like growth factor receptor binding;GO:0005179 hormone activity;GO:0008083 growth factor activity;GO:0005158 insulin receptor binding;GO:0005178 integrin binding", "go_cellular_component": "GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex;GO:0005615 extracellular space;GO:0070382 exocytic vesicle;GO:0098978 glutamatergic synapse;GO:0098794 postsynapse", "go_biological_process": "GO:0008283 cell population proliferation;GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0043410 positive regulation of MAPK cascade;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P07455-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5H9-1", "uniprot_id": [ { "id": "TTC5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5H9", "type": "external" } ], "mass": 48918.0, "length": 440, "protein_name": "Tetratricopeptide repeat protein 5", "gene_name": "TTC5", "organism": "Bovine", "refseq_name": "tetratricopeptide repeat protein 5", "refseq_ac": [ { "id": "NP_001068932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068932", "type": "external" } ], "gene_names_uniprotkb": "TTC5", "gene_names_refseq": "TTC5", "protein_names_uniprotkb": "Tetratricopeptide repeat protein 5; Protein Strap; Stress-responsive activator of p300; TPR repeat protein 5", "protein_names_refseq": "TPR repeat protein 5; protein Strap; strap; stress-responsive activator of p300; tetratricopeptide repeat protein 5", "tax_id": 9913, "disease": "", "pathway": " (bta:510757); (R-BTA-6804760)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cofactor involved in the regulation of various cellular mechanisms such as actin regulation, autophagy, chromatin regulation and DNA repair. In physiological conditions, interacts with cofactor JMY in the cytoplasm which prevents JMY's actin nucleation activity and ability to activate the Arp2/3 complex. Acts as a negative regulator of nutrient stress-induced autophagy by inhibiting JMY's interaction with MAP1LC3B, thereby preventing autophagosome formation (By similarity). Involves in tubulin autoregulation by promoting its degradation in response to excess soluble tubulin. To do so, associates with the active ribosome near the ribosome exit tunnel and with nascent tubulin polypeptides early during their translation, triggering tubulin mRNA-targeted degradation (By similarity). Following DNA damage, phosphorylated by DNA damage responsive protein kinases ATM and CHEK2, leading to its nuclear accumulation and stability. Nuclear TTC5/STRAP promotes the assembly of a stress-responsive p53/TP53 coactivator complex, which includes the coactivators JMY and p300, thereby increasing p53/TP53-dependent transcription and apoptosis. Also recruits arginine methyltransferase PRMT5 to p53/TP53 when DNA is damaged, allowing PRMT5 to methylate p53/TP53. In DNA stress conditions, also prevents p53/TP53 degradation by E3 ubiquitin ligase MDM2. Upon heat-shock stress, forms a chromatin-associated complex with heat-shock factor 1 HSF1 and p300/EP300 to stimulate heat-shock-responsive transcription, thereby increasing cell survival. Mitochondrial TTC5/STRAP interacts with ATP synthase subunit beta ATP5F1B which decreased ATP synthase activity and lowers mitochondrial ATP production, thereby regulating cellular respiration and mitochondrial-dependent apoptosis. Mitochondrial TTC5/STRAP also regulates p53/TP53-mediated apoptosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0061630 ubiquitin protein ligase activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0009267 cellular response to starvation;GO:0010468 regulation of gene expression;GO:0051254 positive regulation of RNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5H9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC81-1", "uniprot_id": [ { "id": "AA3R_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC81", "type": "external" } ], "mass": 35911.0, "length": 317, "protein_name": "Adenosine receptor A3", "gene_name": "ADORA3; TMIGD3", "organism": "Bovine", "refseq_name": "adenosine receptor A3 isoform 1", "refseq_ac": [ { "id": "NP_001098081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098081", "type": "external" } ], "gene_names_uniprotkb": "ADORA3; TMIGD3", "gene_names_refseq": "ADORA3", "protein_names_uniprotkb": "Adenosine receptor A3", "protein_names_refseq": "adenosine receptor A3 isoform 1; adenosine receptor A3", "tax_id": 9913, "disease": "", "pathway": " (bta:104564307); (bta:780806); (R-BTA-417973); (R-BTA-418594)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "G protein-coupled receptor (GPCR) for adenosine that plays significant roles in various physiological processes including immune regulation, cardioprotection and neuroprotection. Also acts as a receptor for adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification, which are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs): activated by N(6)-methyladenosine (m6A), N(6),N(6)-dimethyladenosine (m6,6A) and N(6)-isopentenyladenosine (i6A). Preferentially couples to the inhibitory G protein (Gi), leading to the suppression of adenylate cyclase activity and a reduction in intracellular cyclic AMP levels (By similarity). Upon adenosine binding, mediates cardioprotection in cardiomyocytes through anti-apoptotic effects primarily via the ERK1/2 pathway as well as the PI3K pathway. In the central nervous system, participates in the modulation of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD) in the hippocampus (By similarity). In lung mast cells, receptor activation contributes to the type I allergic response by facilitating mast cell degranulation and histamine release (By similarity). Highly expressed in inflammatory cells such as neutrophils and mast cells, inhibits neutrophil degranulation and reduces superoxide production, thereby modulating inflammatory responses (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase., [UniProtKB, UniProtKB]; This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors involved in a variety of intracellular signaling pathways and physiological functions. Studies of orthologous proteins suggest that the receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it may have neuroprotective and neurodegenerative effects, and it may also mediate cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:104564307, which encodes a transmembrane and immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001609 G protein-coupled adenosine receptor activity;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse;GO:0016020 membrane", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0001973 G protein-coupled adenosine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VC81-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIH4-1", "uniprot_id": [ { "id": "CHAC2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIH4", "type": "external" } ], "mass": 20063.0, "length": 176, "protein_name": "Putative glutathione-specific gamma-glutamylcyclotransferase 2", "gene_name": "CHAC2", "organism": "Bovine", "refseq_name": "putative glutathione-specific gamma-glutamylcyclotransferase 2", "refseq_ac": [ { "id": "NP_001068996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068996", "type": "external" } ], "gene_names_uniprotkb": "CHAC2", "gene_names_refseq": "CHAC2", "protein_names_uniprotkb": "Putative glutathione-specific gamma-glutamylcyclotransferase 2; 4.3.2.7; Cation transport regulator-like protein 2; Gamma-GCG 2", "protein_names_refseq": "ChaC cation transport regulator homolog 2; cation transport regulator-like protein 2; gamma-GCG 2; putative glutathione-specific gamma-glutamylcyclotransferase 2", "tax_id": 9913, "disease": "", "pathway": " (bta:511605); (R-BTA-174403)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.3.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.7", "type": "external" } ], "go_molecular_function": "GO:0061928 glutathione specific gamma-glutamylcyclotransferase activity;GO:0003839 gamma-glutamylcyclotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006751 glutathione catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0IIH4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C0T1-1", "uniprot_id": [ { "id": "ITPK1_BOVIN", "url": "https://www.uniprot.org/uniprot/P0C0T1", "type": "external" } ], "mass": 45842.0, "length": 419, "protein_name": "Inositol-tetrakisphosphate 1-kinase", "gene_name": "ITPK1", "organism": "Bovine", "refseq_name": "inositol-tetrakisphosphate 1-kinase", "refseq_ac": [ { "id": "NP_001179418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179418", "type": "external" } ], "gene_names_uniprotkb": "ITPK1", "gene_names_refseq": "ITPK1", "protein_names_uniprotkb": "Inositol-tetrakisphosphate 1-kinase; 2.7.1.134; 2.7.1.159; Inositol 1,3,4-trisphosphate 5/6-kinase; Inositol-triphosphate 5/6-kinase; Ins(1,3,4)P(3) 5/6-kinase", "protein_names_refseq": "inositol 1,3,4-triphosphate 5/6 kinase; inositol 1,3,4-trisphosphate 5/6-kinase; inositol-tetrakisphosphate 1-kinase; inositol-triphosphate 5/6-kinase; ins(1,3,4)P(3) 5/6-kinase", "tax_id": 9913, "disease": "", "pathway": " (bta:518488); (R-BTA-1855167); (R-BTA-1855204); (R-BTA-983231)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "8662638", "class_list": "", "function": "Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway (PubMed:8662638). Also acts as an inositol polyphosphate phosphatase that dephosphorylates Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain. Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.7.1.134", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.134", "type": "external" }, { "id": "2.7.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.159", "type": "external" } ], "go_molecular_function": "GO:0047325 inositol-3,4,5,6-tetrakisphosphate 1-kinase activity;GO:0052725 inositol-1,3,4-trisphosphate 6-kinase activity;GO:0052726 inositol-1,3,4-trisphosphate 5-kinase activity;GO:0052835 inositol-3,4,6-trisphosphate 1-kinase activity;GO:0000287 magnesium ion binding", "go_cellular_component": "GO:0016324 apical plasma membrane", "go_biological_process": "GO:0070266 necroptotic process;GO:0032957 inositol trisphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C0T1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79244-1", "uniprot_id": [ { "id": "RL37_BOVIN", "url": "https://www.uniprot.org/uniprot/P79244", "type": "external" } ], "mass": 11078.0, "length": 97, "protein_name": "Large ribosomal subunit protein eL37", "gene_name": "RPL37", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein eL37", "refseq_ac": [ { "id": "NP_001071600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071600", "type": "external" } ], "gene_names_uniprotkb": "RPL37", "gene_names_refseq": "RPL37", "protein_names_uniprotkb": "Large ribosomal subunit protein eL37; 60S ribosomal protein L37", "protein_names_refseq": "60S ribosomal protein L37; large ribosomal subunit protein eL37", "tax_id": 9913, "disease": "", "pathway": " (bta:768317); (R-BTA-156827); (R-BTA-1799339); (R-BTA-6791226); (R-BTA-72689); (R-BTA-72706); (R-BTA-975956); (R-BTA-975957); (R-BTA-9954709); (R-BTA-9954714); (R-BTA-9954716)", "pathway_count": 11, "publication_count": 1, "publication_id_list": "7588717", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QLM5;Q3T109", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0045202 synapse;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P79244-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V8R5-1", "uniprot_id": [ { "id": "IL16_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V8R5", "type": "external" } ], "mass": 66428.0, "length": 627, "protein_name": "Pro-interleukin-16", "gene_name": "IL16", "organism": "Bovine", "refseq_name": "pro-interleukin-16", "refseq_ac": [ { "id": "NP_001068721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068721", "type": "external" } ], "gene_names_uniprotkb": "IL16", "gene_names_refseq": "IL16", "protein_names_uniprotkb": "Pro-interleukin-16; LCF; Lymphocyte chemoattractant factor", "protein_names_refseq": "interleukin 16 (lymphocyte chemoattractant factor); pro-interleukin-16", "tax_id": 9913, "disease": "", "pathway": " (bta:506314)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Pro-interleukin-16 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0042609 CD4 receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006935 chemotaxis;GO:0050930 induction of positive chemotaxis;GO:0032730 positive regulation of interleukin-1 alpha production;GO:0032755 positive regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0V8R5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32850-1", "uniprot_id": [ { "id": "STX1A_BOVIN", "url": "https://www.uniprot.org/uniprot/P32850", "type": "external" } ], "mass": 33091.0, "length": 288, "protein_name": "Syntaxin-1A", "gene_name": "STX1A", "organism": "Bovine", "refseq_name": "syntaxin-1A isoform X1", "refseq_ac": [ { "id": "XP_005225301", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005225301", "type": "external" } ], "gene_names_uniprotkb": "STX1A", "gene_names_refseq": "STX1A", "protein_names_uniprotkb": "Syntaxin-1A; Neuron-specific antigen HPC-1; P35A; Synaptotagmin-associated 35 kDa protein", "protein_names_refseq": "syntaxin-1A isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-181429); (R-BTA-181430); (R-BTA-210500); (R-BTA-212676); (R-BTA-264642); (R-BTA-449836); (R-BTA-5682910); (R-BTA-888590); (R-BTA-9609523)", "pathway_count": 9, "publication_count": 3, "publication_id_list": "1530610;8455717;8611567", "class_list": "", "function": "Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion (By similarity). Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm. Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity;GO:0019869 chloride channel inhibitor activity;GO:0042802 identical protein binding;GO:0019900 kinase binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0043005 neuron projection;GO:0030672 synaptic vesicle membrane;GO:0031201 SNARE complex", "go_biological_process": "GO:0010701 positive regulation of norepinephrine secretion;GO:0006886 intracellular protein transport;GO:0006887 exocytosis;GO:0033605 positive regulation of catecholamine secretion;GO:0045956 positive regulation of calcium ion-dependent exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P32850-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P565-1", "uniprot_id": [ { "id": "HDDC2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P565", "type": "external" } ], "mass": 23323.0, "length": 205, "protein_name": "5'-deoxynucleotidase HDDC2", "gene_name": "HDDC2", "organism": "Bovine", "refseq_name": "5'-deoxynucleotidase HDDC2", "refseq_ac": [ { "id": "NP_001068869", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068869", "type": "external" } ], "gene_names_uniprotkb": "HDDC2", "gene_names_refseq": "HDDC2", "protein_names_uniprotkb": "5'-deoxynucleotidase HDDC2; 3.1.3.89; HD domain-containing protein 2", "protein_names_refseq": "5'-deoxynucleotidase HDDC2; HD domain-containing protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:509282)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.91", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.91", "type": "external" }, { "id": "3.1.3.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.89", "type": "external" }, { "id": "3.1.3.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.99", "type": "external" }, { "id": "3.1.3.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.35", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0002953 5'-deoxynucleotidase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009159 deoxyribonucleoside monophosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P565-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V882-1", "uniprot_id": [ { "id": "BI1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V882", "type": "external" } ], "mass": 26366.0, "length": 236, "protein_name": "Bax inhibitor 1", "gene_name": "TMBIM6", "organism": "Bovine", "refseq_name": "bax inhibitor 1", "refseq_ac": [ { "id": "NP_001069882", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069882", "type": "external" } ], "gene_names_uniprotkb": "TMBIM6; TEGT", "gene_names_refseq": "TEGT; TMBIM6", "protein_names_uniprotkb": "Bax inhibitor 1; BI-1; Testis-enhanced gene transcript protein; Transmembrane BAX inhibitor motif-containing protein 6", "protein_names_refseq": "BI-1; bax inhibitor 1; testis enhanced gene transcript (BAX inhibitor 1); testis-enhanced gene transcript protein; transmembrane BAX inhibitor motif-containing protein 6", "tax_id": 9913, "disease": "", "pathway": " (bta:616210)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Endoplasmic reticulum (ER)-resident protein that confers cellular protection as an anti-apoptotic protein by limiting multiple stress-inducing pathways surrounding the endoplasmic reticulum and mitochondria. Inhibits the activities of the key sensor for the endoplasmic reticulum unfolded protein response IRE1alpha/ERN1 both directly and by blocking BAX/BAK binding. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0060698 endoribonuclease inhibitor activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0006915 apoptotic process;GO:0006914 autophagy;GO:2001234 negative regulation of apoptotic signaling pathway;GO:0034620 cellular response to unfolded protein;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0V882-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49259-1", "uniprot_id": [ { "id": "PLA2R_BOVIN", "url": "https://www.uniprot.org/uniprot/P49259", "type": "external" } ], "mass": 168651.0, "length": 1463, "protein_name": "Secretory phospholipase A2 receptor", "gene_name": "PLA2R1", "organism": "Bovine", "refseq_name": "secretory phospholipase A2 receptor precursor", "refseq_ac": [ { "id": "NP_778221", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778221", "type": "external" } ], "gene_names_uniprotkb": "PLA2R1", "gene_names_refseq": "PLA2-R; PLA2R1", "protein_names_uniprotkb": "Secretory phospholipase A2 receptor; 180 kDa secretory phospholipase A2 receptor; M-type receptor; PLA2-R; PLA2R", "protein_names_refseq": "M-type receptor; phospholipase A2 receptor 1, 180kDa; secretory phospholipase A2 receptor precursor; secretory phospholipase A2 receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:317777); (R-BTA-1482788); (R-BTA-1482801); (R-BTA-1482839); (R-BTA-1482922); (R-BTA-1482925); (R-BTA-1483166)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "7509792;7726849", "class_list": "", "function": "Receptor for secretory phospholipase A2 (sPLA2). Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in pro-inflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B and sPLA2-X/PLA2G10., [UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0030246 carbohydrate binding;GO:0043274 phospholipase binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009986 cell surface", "go_biological_process": "GO:0001819 positive regulation of cytokine production;GO:0006898 receptor-mediated endocytosis;GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator;GO:0072593 reactive oxygen species metabolic process;GO:0090399 replicative senescence", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P49259-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DK9-1", "uniprot_id": [ { "id": "PWP3A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DK9", "type": "external" } ], "mass": 71109.0, "length": 641, "protein_name": "PWWP domain-containing DNA repair factor 3A", "gene_name": "PWWP3A", "organism": "Bovine", "refseq_name": "PWWP domain-containing DNA repair factor 3A", "refseq_ac": [ { "id": "NP_001069090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069090", "type": "external" } ], "gene_names_uniprotkb": "PWWP3A; MUM1", "gene_names_refseq": "MUM1; PWWP3A", "protein_names_uniprotkb": "PWWP domain-containing DNA repair factor 3A; MUM-1; Mutated melanoma-associated antigen 1; PWWP domain-containing protein MUM1; PWWP3A", "protein_names_refseq": "MUM-1; PWWP domain-containing DNA repair factor 3A; PWWP domain-containing protein MUM1; melanoma associated antigen (mutated) 1; mutated melanoma-associated antigen 1", "tax_id": 9913, "disease": "", "pathway": " (bta:513471)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DK9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P67808-1", "uniprot_id": [ { "id": "YBOX1_BOVIN", "url": "https://www.uniprot.org/uniprot/P67808", "type": "external" } ], "mass": 35924.0, "length": 324, "protein_name": "Y-box-binding protein 1", "gene_name": "YBX1", "organism": "Bovine", "refseq_name": "Y-box-binding protein 1", "refseq_ac": [ { "id": "NP_777240", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777240", "type": "external" } ], "gene_names_uniprotkb": "YBX1; YB1", "gene_names_refseq": "NSEP1; YB1; YBX1", "protein_names_uniprotkb": "Y-box-binding protein 1; DBPB; DNA-binding protein B; EFI-A; Enhancer factor I subunit A; Y-box transcription factor; YB-1", "protein_names_refseq": "CBF-A; CCAAT-binding transcription factor I subunit A; DBPB; DNA-binding protein B; EFI-A; Y-box transcription factor; Y-box-binding protein 1; YB-1; enhancer factor I subunit A; nuclease-sensitive element-binding protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:287023); (R-BTA-72163); (R-BTA-72165); (R-BTA-72203); (R-BTA-877300); (R-BTA-9770562)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "8444345", "class_list": "", "function": "DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation. Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay. Component of the CRD-mediated complex that promotes MYC mRNA stability (By similarity). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs. Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs. Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs. Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection. Binds to TSC22D1 transcripts, thereby inhibiting their translation and negatively regulating TGF-beta-mediated transcription of COL1A2 (By similarity). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair. The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P16990;P16991;Q2KJF8", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003676 nucleic acid binding;GO:0035198 miRNA binding;GO:0003697 single-stranded DNA binding;GO:0062153 C5-methylcytidine-containing RNA reader activity", "go_cellular_component": "GO:0071204 histone pre-mRNA 3'end processing complex;GO:0005634 nucleus;GO:0070062 extracellular exosome;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0070934 CRD-mediated mRNA stabilization;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0048255 mRNA stabilization;GO:0008544 epidermis development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P67808-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DA0-1", "uniprot_id": [ { "id": "RABL6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DA0", "type": "external" } ], "mass": 77097.0, "length": 701, "protein_name": "Rab-like protein 6", "gene_name": "RABL6", "organism": "Bovine", "refseq_name": "rab-like protein 6", "refseq_ac": [ { "id": "NP_001070285", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070285", "type": "external" } ], "gene_names_uniprotkb": "RABL6; PARF", "gene_names_refseq": "C11H9orf86; PARF; RABL6; RBEL1", "protein_names_uniprotkb": "Rab-like protein 6; 3.6.5.2; GTP-binding protein Parf; RBEL1; Rab-like protein 1", "protein_names_refseq": "Rab-like GTP-binding protein 1A; partner of ARF; putative GTP-binding protein Parf; rab-like protein 1; rab-like protein 6", "tax_id": 9913, "disease": "", "pathway": " (bta:508218)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Small GTPase involved in the regulation of cell growth and survival. Promotes cellular proliferation. May reduce growth inhibitory activity of CDKN2A., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity;GO:0003924 GTPase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DA0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DY8-1", "uniprot_id": [ { "id": "ATG13_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DY8", "type": "external" } ], "mass": 52426.0, "length": 480, "protein_name": "Autophagy-related protein 13", "gene_name": "ATG13", "organism": "Bovine", "refseq_name": "autophagy-related protein 13", "refseq_ac": [ { "id": "NP_001070280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070280", "type": "external" } ], "gene_names_uniprotkb": "ATG13", "gene_names_refseq": "ATG13", "protein_names_uniprotkb": "Autophagy-related protein 13", "protein_names_refseq": "ATG13 autophagy related 13 homolog; autophagy-related protein 13", "tax_id": 9913, "disease": "", "pathway": " (bta:507340); (R-BTA-1632852)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019887 protein kinase regulator activity;GO:0019209 kinase activator activity;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005776 autophagosome;GO:0000407 phagophore assembly site;GO:1990316 Atg1/ULK1 kinase complex;GO:0005739 mitochondrion", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0042127 regulation of cell population proliferation;GO:0010508 positive regulation of autophagy;GO:0034497 protein localization to phagophore assembly site;GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DY8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52556-1", "uniprot_id": [ { "id": "BLVRB_BOVIN", "url": "https://www.uniprot.org/uniprot/P52556", "type": "external" } ], "mass": 22132.0, "length": 206, "protein_name": "Flavin reductase (NADPH)", "gene_name": "BLVRB", "organism": "Bovine", "refseq_name": "flavin reductase (NADPH)", "refseq_ac": [ { "id": "NP_776676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776676", "type": "external" } ], "gene_names_uniprotkb": "BLVRB; SCAN", "gene_names_refseq": "BLVRB", "protein_names_uniprotkb": "Flavin reductase (NADPH); 1.3.1.-; 1.5.1.30; 2.6.99.-; BVR-B; Biliverdin reductase B; Biliverdin-IX beta-reductase; FLR; FR; GHBP; Green heme-binding protein; NADPH-dependent diaphorase; NADPH-flavin reductase; S-nitroso-CoA-assisted nitrosyltransferase; SNO-CoA-assisted nitrosyltransferase", "protein_names_refseq": "BVR-B; FLR; FR; GHBP; NADPH-dependent diaphorase; NADPH-flavin reductase; S-nitroso-CoA-assisted nitrosyltransferase; SNO-CoA-assisted nitrosyltransferase; biliverdin-IX beta-reductase; flavin reductase (NADPH); green heme-binding protein", "tax_id": 9913, "disease": "", "pathway": " (bta:281650); (R-BTA-189483); (R-BTA-9707564)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "2069570;7937764", "class_list": "", "function": "Enzyme that can both act as a NAD(P)H-dependent reductase and a S-nitroso-CoA-dependent nitrosyltransferase. Promotes fetal heme degradation during development. Also expressed in adult tissues, where it acts as a regulator of hematopoiesis, intermediary metabolism (glutaminolysis, glycolysis, TCA cycle and pentose phosphate pathway) and insulin signaling. Has a broad specificity oxidoreductase activity by catalyzing the NAD(P)H-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to fetal heme catabolism by catalyzing reduction of biliverdin IXbeta into bilirubin IXbeta in the liver. Biliverdin IXbeta, which constitutes the major heme catabolite in the fetus is not present in adult. Does not reduce bilirubin IXalpha. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. Acts as a protein nitrosyltransferase by catalyzing nitrosylation of cysteine residues of target proteins, such as HMOX2, INSR and IRS1. S-nitroso-CoA-dependent nitrosyltransferase activity is mediated via a 'ping-pong' mechanism: BLVRB first associates with both S-nitroso-CoA and protein substrate, nitric oxide group is then transferred from S-nitroso-CoA to Cys-109 and Cys-188 residues of BLVRB and from S-nitroso-BLVRB to the protein substrate. Inhibits insulin signaling by mediating nitrosylation of INSR and IRS1, leading to their inhibition., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0T4", "ec_number_list": [ { "id": "1.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.-", "type": "external" }, { "id": "2.6.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.99.-", "type": "external" }, { "id": "1.5.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.30", "type": "external" } ], "go_molecular_function": "GO:0035605 peptidyl-cysteine S-nitrosylase activity;GO:0004074 biliverdin reductase [NAD(P)H] activity;GO:0042602 riboflavin reductase (NADPH) activity;GO:0052873 FMN reductase (NADPH) activity;GO:0052874 FMN reductase (NADH) activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0042167 heme catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P52556-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05B63-1", "uniprot_id": [ { "id": "TRM11_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05B63", "type": "external" } ], "mass": 53039.0, "length": 460, "protein_name": "tRNA (guanine(10)-N(2))-methyltransferase TRMT11", "gene_name": "TRMT11", "organism": "Bovine", "refseq_name": "tRNA (guanine(10)-N(2))-methyltransferase TRMT11", "refseq_ac": [ { "id": "NP_001073742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073742", "type": "external" } ], "gene_names_uniprotkb": "TRMT11", "gene_names_refseq": "TRMT11", "protein_names_uniprotkb": "tRNA (guanine(10)-N(2))-methyltransferase TRMT11; 2.1.1.214; tRNA methyltransferase 11 homolog", "protein_names_refseq": "tRNA (guanine(10)-N(2))-methyltransferase TRMT11; tRNA (guanine(10)-N(2))-methyltransferase homolog; tRNA (guanine(10)-N2)-methyltransferase homolog; tRNA guanosine-2'-O-methyltransferase TRM11 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:514867)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic subunit of the TRMT11-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 10 (m2G10) in tRNAs. This is one of the major tRNA (guanine-N(2))-methyltransferases., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.214", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.214", "type": "external" } ], "go_molecular_function": "GO:0000049 tRNA binding;GO:0008168 methyltransferase activity;GO:0160102 tRNA (guanine(10)-N2)-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0043528 tRNA (m2G10) methyltransferase complex;GO:0043527 tRNA methyltransferase complex", "go_biological_process": "GO:0008033 tRNA processing;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q05B63-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC65-1", "uniprot_id": [ { "id": "ETV6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC65", "type": "external" } ], "mass": 52992.0, "length": 452, "protein_name": "Transcription factor ETV6", "gene_name": "ETV6", "organism": "Bovine", "refseq_name": "transcription factor ETV6", "refseq_ac": [ { "id": "NP_001015514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015514", "type": "external" } ], "gene_names_uniprotkb": "ETV6", "gene_names_refseq": "ETV6; TEL", "protein_names_uniprotkb": "Transcription factor ETV6", "protein_names_refseq": "ets variant gene 6 (TEL oncogene); transcription factor ETV6", "tax_id": 9913, "disease": "", "pathway": " (bta:504512)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0019904 protein domain specific binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0071425 hematopoietic stem cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VC65-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63243-1", "uniprot_id": [ { "id": "RACK1_BOVIN", "url": "https://www.uniprot.org/uniprot/P63243", "type": "external" } ], "mass": 35077.0, "length": 317, "protein_name": "Small ribosomal subunit protein RACK1", "gene_name": "RACK1", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein RACK1", "refseq_ac": [ { "id": "NP_786996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786996", "type": "external" } ], "gene_names_uniprotkb": "RACK1; GNB2L1", "gene_names_refseq": "GNB2L1; RACK1", "protein_names_uniprotkb": "Small ribosomal subunit protein RACK1; Guanine nucleotide-binding protein subunit beta-2-like 1; Receptor for activated C kinase; Receptor of activated protein C kinase 1, N-terminally processed; Receptor of activated protein C kinase 1; Receptor of activated protein kinase C 1", "protein_names_refseq": "guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1; guanine nucleotide-binding protein subunit beta-2-like 1; receptor of activated protein C kinase 1; receptor of activated protein kinase C 1; small ribosomal subunit protein RACK1", "tax_id": 9913, "disease": "", "pathway": " (bta:327682); (R-BTA-5357905); (R-BTA-5357956); (R-BTA-5626978); (R-BTA-9766229)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "11099474;17875659", "class_list": "", "function": "Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (By similarity). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (By similarity). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation (By similarity). May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6 (By similarity). Inhibits the activity of SRC kinases including SRC, LCK and YES1 (By similarity). Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle (By similarity). Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer (By similarity). Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC (By similarity). Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix (By similarity). Involved in PKC-dependent translocation of ADAM12 to the cell membrane (By similarity). Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A (By similarity). Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation (By similarity). Required for PTK2/FAK1 phosphorylation and dephosphorylation (By similarity). Regulates internalization of the muscarinic receptor CHRM2 (By similarity). Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L (By similarity). Inhibits TRPM6 channel activity (By similarity). Regulates cell surface expression of some GPCRs such as TBXA2R (By similarity). Plays a role in regulation of FLT1-mediated cell migration (By similarity). Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (By similarity). Acts as an adapter for the dephosphorylation and inactivation of AKT1 by promoting recruitment of PP2A phosphatase to AKT1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; These results suggest that PKCepsilon signaling in the basal airway cell may involve RACK1; however, PKCepsilon regulation in ciliated cells uses RACK1-independent pathways., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P25388;P99049;Q3T0R8", "ec_number_list": [], "go_molecular_function": "GO:0005080 protein kinase C binding;GO:0042169 SH2 domain binding;GO:0030971 receptor tyrosine kinase binding;GO:0043022 ribosome binding;GO:0045182 translation regulator activity", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030425 dendrite", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0001934 positive regulation of protein phosphorylation;GO:0030335 positive regulation of cell migration;GO:0043065 positive regulation of apoptotic process;GO:0043547 positive regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P63243-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13214-1", "uniprot_id": [ { "id": "ANXA4_BOVIN", "url": "https://www.uniprot.org/uniprot/P13214", "type": "external" } ], "mass": 35889.0, "length": 319, "protein_name": "Annexin A4", "gene_name": "ANXA4", "organism": "Bovine", "refseq_name": "annexin A4", "refseq_ac": [ { "id": "NP_001001440", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001440", "type": "external" } ], "gene_names_uniprotkb": "ANXA4; ANX4", "gene_names_refseq": "ANXA4", "protein_names_uniprotkb": "Annexin A4; 35-beta calcimedin; Annexin IV; Annexin-4; Carbohydrate-binding protein p33/p41; Chromobindin-4; Endonexin I; Lipocortin IV; P32.5; PAP-II; PP4-X; Placental anticoagulant protein II; Protein II", "protein_names_refseq": "35-beta calcimedin; P32.5; PAP-II; PP4-X; annexin A4; annexin IV; annexin-4; carbohydrate-binding protein p33/p41; chromobindin-4; endonexin I; lipocortin IV; placental anticoagulant protein II; protein II", "tax_id": 9913, "disease": "", "pathway": " (bta:281625)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12693987;1400371;2847715;7492310;8631806;9405281", "class_list": "", "function": "First detection of annexin IV in vertebrate retina, [RefSeq, PubMed]; May play a role in alveolar type II cells through interaction with the surfactant protein SFTPA1 (SP-A)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SYU5", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0005544 calcium-dependent phospholipid binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0030855 epithelial cell differentiation;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway;GO:0032717 negative regulation of interleukin-8 production", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P13214-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15691-1", "uniprot_id": [ { "id": "VEGFA_BOVIN", "url": "https://www.uniprot.org/uniprot/P15691", "type": "external" } ], "mass": 22310.0, "length": 190, "protein_name": "Vascular endothelial growth factor A", "gene_name": "VEGFA", "organism": "Bovine", "refseq_name": "vascular endothelial growth factor A isoform VEGF-Ax precursor", "refseq_ac": [ { "id": "NP_001303884", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303884", "type": "external" } ], "gene_names_uniprotkb": "VEGFA; VEGF", "gene_names_refseq": "VEGF-A; VEGFA; VEGF; VPF; eVEGF120; eVEGF164", "protein_names_uniprotkb": "Vascular endothelial growth factor A; VEGF-A; VPF; Vascular permeability factor", "protein_names_refseq": "vascular endothelial growth factor 164; vascular endothelial growth factor A isoform VEGF-Ax precursor; vascular permeability factor", "tax_id": 9913, "disease": "", "pathway": " (bta:281572); (R-BTA-114608); (R-BTA-194313); (R-BTA-195399); (R-BTA-4420097); (R-BTA-5218921)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "2479986;24949972;2610687;2735925;31301448;31546232;31952188", "class_list": "", "function": "Evidence of an altered expression of VEGFA-164, VEGFA-164b and VEGFR2 during the formation of persistent follicles and cysts in cows., [RefSeq, PubMed]; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MiR-21-3p inhibits bovine primary ovarian granulosa cells autophagy by targeting VEGFA and attenuating PI3K/AKT signaling., [RefSeq, PubMed]; Study shows that VEGFA mRNA in mammalian endothelial cells undergoes programmed translational readthrough (PTR) generating VEGF-Ax, an isoform containing a unique 22-amino-acid C terminus extension., [RefSeq, PubMed]; This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. It is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. [provided by RefSeq, Nov 2015]., [RefSeq]; Vascular Endothelial Growth Factor A and VEGFR-1 Change during Preimplantation in Heifers. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0042056 chemoattractant activity;GO:0042803 protein homodimerization activity;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0005634 nucleus;GO:0005912 adherens junction;GO:0009986 cell surface", "go_biological_process": "GO:0097475 motor neuron migration;GO:0001934 positive regulation of protein phosphorylation;GO:0001666 response to hypoxia;GO:0010595 positive regulation of endothelial cell migration;GO:0045766 positive regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P15691-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5J0-1", "uniprot_id": [ { "id": "QRIC1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5J0", "type": "external" } ], "mass": 86752.0, "length": 779, "protein_name": "Transcriptional regulator QRICH1", "gene_name": "QRICH1", "organism": "Bovine", "refseq_name": "transcriptional regulator QRICH1", "refseq_ac": [ { "id": "NP_001091484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091484", "type": "external" } ], "gene_names_uniprotkb": "QRICH1", "gene_names_refseq": "QRICH1", "protein_names_uniprotkb": "Transcriptional regulator QRICH1; Glutamine-rich protein 1", "protein_names_refseq": "glutamine-rich protein 1; transcriptional regulator QRICH1", "tax_id": 9913, "disease": "", "pathway": " (bta:511970)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress. Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway. ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR. May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability. Up-regulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver. Core component of the zincore complex, a heterotetramer that acts as a molecular 'grip' to stabilize transcription factors at DNA-binding sites across the genome, thereby controlling gene expression. The zincore complex binds specifically to zinc finger transcription factors, such as ZFP91, ZNF652, ZNF526 and PRDM15, and stabilizes them onto their cognate DNA motif. Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D7N1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005694 chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0043065 positive regulation of apoptotic process;GO:0045893 positive regulation of DNA-templated transcription;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5J0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02827-1", "uniprot_id": [ { "id": "NDUC2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q02827", "type": "external" } ], "mass": 14096.0, "length": 120, "protein_name": "NADH dehydrogenase [ubiquinone] 1 subunit C2", "gene_name": "NDUFC2", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 subunit C2", "refseq_ac": [ { "id": "NP_788815", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788815", "type": "external" } ], "gene_names_uniprotkb": "NDUFC2", "gene_names_refseq": "NDUFC2", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 subunit C2; CI-B14.5b; Complex I-B14.5b; NADH-ubiquinone oxidoreductase subunit B14.5b", "protein_names_refseq": "CI-B14.5b; NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa; NADH dehydrogenase [ubiquinone] 1 subunit C2; NADH-ubiquinone oxidoreductase subunit B14.5b; complex I-B14.5b", "tax_id": 9913, "disease": "", "pathway": " (bta:338046); (R-BTA-611105); (R-BTA-6798695); (R-BTA-6799198)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "1426273;18721790;28100784", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis but required for the complex assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZR4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q02827-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08E27-1", "uniprot_id": [ { "id": "STRBP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08E27", "type": "external" } ], "mass": 73594.0, "length": 672, "protein_name": "Spermatid perinuclear RNA-binding protein", "gene_name": "STRBP", "organism": "Bovine", "refseq_name": "spermatid perinuclear RNA-binding protein", "refseq_ac": [ { "id": "NP_001069207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069207", "type": "external" } ], "gene_names_uniprotkb": "STRBP", "gene_names_refseq": "STRBP", "protein_names_uniprotkb": "Spermatid perinuclear RNA-binding protein", "protein_names_refseq": "spermatid perinuclear RNA-binding protein", "tax_id": 9913, "disease": "", "pathway": " (bta:516282)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003725 double-stranded RNA binding;GO:0003727 single-stranded RNA binding;GO:0003723 RNA binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005634 nucleus;GO:0002177 manchette", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08E27-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84798-1", "uniprot_id": [ { "id": "DPOD3_BOVIN", "url": "https://www.uniprot.org/uniprot/P84798", "type": "external" } ], "mass": 52074.0, "length": 466, "protein_name": "DNA polymerase delta subunit 3", "gene_name": "POLD3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "POLD3", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA polymerase delta subunit 3; DNA polymerase delta subunit p66; p68", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-110314); (R-BTA-174411); (R-BTA-174414); (R-BTA-174417); (R-BTA-174437); (R-BTA-5358565); (R-BTA-5358606); (R-BTA-5651801); (R-BTA-5656169); (R-BTA-5685942); (R-BTA-5693537); (R-BTA-5696397); (R-BTA-5696400); (R-BTA-6782135); (R-BTA-6782210); (R-BTA-69091); (R-BTA-69166); (R-BTA-69183)", "pathway_count": 18, "publication_count": 1, "publication_id_list": "10751307", "class_list": "", "function": "Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex. As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA. Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4. Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. In this context, POLD3, along with PCNA and RFC1-replication factor C complex, is required to recruit POLD1, the catalytic subunit of the polymerase delta complex, to DNA damage sites. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS, as a component of the tetrameric DNA polymerase zeta complex. Along with POLD2, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0043625 delta DNA polymerase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006271 DNA strand elongation involved in DNA replication;GO:0006297 nucleotide-excision repair, DNA gap filling;GO:1904161 DNA synthesis involved in UV-damage excision repair;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P84798-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05980-1", "uniprot_id": [ { "id": "AK1C3_BOVIN", "url": "https://www.uniprot.org/uniprot/P05980", "type": "external" } ], "mass": 36720.0, "length": 323, "protein_name": "Aldo-keto reductase family 1 member C3", "gene_name": "AKR1C3; LOC782922", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AKR1C3; LOC782922", "gene_names_refseq": "", "protein_names_uniprotkb": "Aldo-keto reductase family 1 member C3; 1.1.1.-; 1.1.1.188; 1.1.1.210; 1.1.1.239; 1.1.1.357; 1.1.1.53; 1.1.1.62; 1.1.1.64; 17-beta-HSD 5; 17-beta-hydroxysteroid dehydrogenase type 5; 3-alpha-HSD type 2; 3-alpha-HSD type II, brain; 3-alpha-hydroxysteroid dehydrogenase type 2; Chlordecone reductase homolog HAKRb; DD-3; DD3; Dihydrodiol dehydrogenase 3; Dihydrodiol dehydrogenase type I; PGF synthase; PGFSII; PGFS; PGF; Prostaglandin F synthase II; Prostaglandin F synthase; Prostaglandin-D2 11 reductase 1; Testosterone 17-beta-dehydrogenase 5", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:782922)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1339268;2829166", "class_list": "", "function": "Cytosolic aldo-keto reductase that catalyzes NADPH-dependent reduction of ketosteroids to hydroxysteroids. Displays broad substrate specificity with distinct positional and stereochemistry, primarily generating 17beta-hydroxysteroids, but also 3alpha- and 20alpha-hydroxysteroids. Produces potent androgens via classical and 'backdoor'/alternative pathways. In the classical androgen metabolic pathway (biosynthesis of 5alpha-dihydrotestosterone (5alpha-DHT) via testosterone), catalyzes the reduction of delta4-androstenedione to form testosterone. In the 'backdoor' androgen metabolic pathway (biosynthesis of 5alpha-dihydrotestosterone (5alpha-DHT) via pregnanes), reduces androsterone to 5alpha-androstane-3alpha,17beta-diol preceding 5alpha-DHT secretion. Reduces 5alpha-DHT to less potent androgen 5alpha-androstane-3alpha,17beta-diol, likely regulating ligand availability for androgen receptors. May contribute to the metabolism of adrenal-derived androgen precursors. Reduces 11-keto-4-androstene-3,17-dione (11KA4) and 11-keto-5alpha-androstane-3,17-dione (11K-Adione) into potent androgens 11-ketotestosterone (11KT) and 11-ketodihydrotestosterone (11KDHT), respectively. In estrogen metabolism, catalyzes the conversion of estrone to potent estrogen 17beta-estradiol (By similarity). Acts as a prostaglandin (PG) F2alpha synthase. Displays 11-ketoreductase and 9,11-endoperoxide reductase activities and reduces PGD2 to 11beta-PGF2alpha and PGH2 to PGF2alpha (PubMed:1339268). Also displays retinaldehyde reductase activity toward 9-cis-retinal. In vitro can efficiently catalyze bidirectional conversion between ketosteroids and hydroxysteroids using NADPH/NADP(+) or NADH/NAD(+) as cofactors. In vivo however, the reductase activity prevails since the major reducing cofactor NADPH inhibits NAD(+)-dependent oxidase activity (By similarity). In addition, it is able to reduce in vitro various carbonyl compounds like menadione, phenanthrenequinone and nitrobenzaldehyde (PubMed:1339268)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P52897", "ec_number_list": [ { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "1.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.21", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "1.1.1.n12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12", "type": "external" }, { "id": "1.1.1.330", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.330", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.357", "type": "external" }, { "id": "1.1.1.188", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.188", "type": "external" }, { "id": "1.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.64", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" }, { "id": "1.1.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.225", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.51", "type": "external" }, { "id": "1.1.1.315", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.315", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.1.1.189", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.189", "type": "external" }, { "id": "1.1.1.197", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.197", "type": "external" }, { "id": "1.1.1.196", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.196", "type": "external" }, { "id": "1.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.71", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" }, { "id": "1.1.1.270", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270", "type": "external" } ], "go_molecular_function": "GO:0016229 steroid dehydrogenase activity;GO:0004032 aldose reductase (NADPH) activity;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0036130 prostaglandin H2 endoperoxidase reductase activity;GO:0036131 prostaglandin D2 11-ketoreductase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0008202 steroid metabolic process;GO:0001516 prostaglandin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P05980-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00766-1", "uniprot_id": [ { "id": "CTRA_BOVIN", "url": "https://www.uniprot.org/uniprot/P00766", "type": "external" } ], "mass": 25666.0, "length": 245, "protein_name": "Chymotrypsinogen A", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Chymotrypsinogen A; 3.4.21.1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 9, "publication_id_list": "14151403;4046030;4399050;5442169;5764436;5971783;5971785;5972866;6914398", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0097655 serpin family protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0097180 serine protease inhibitor complex", "go_biological_process": "GO:0006508 proteolysis;GO:0007586 digestion", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P00766-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DS7-1", "uniprot_id": [ { "id": "AP1B1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DS7", "type": "external" } ], "mass": 105706.0, "length": 951, "protein_name": "AP-1 complex subunit beta-1", "gene_name": "AP2B1", "organism": "Bovine", "refseq_name": "AP-2 complex subunit beta", "refseq_ac": [ { "id": "NP_001068593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068593", "type": "external" } ], "gene_names_uniprotkb": "AP2B1; CLAPB1", "gene_names_refseq": "AP2B1; CLAPB1", "protein_names_uniprotkb": "AP-1 complex subunit beta-1; Adaptor protein complex AP-1 subunit beta-1; Adaptor-related protein complex 1 subunit beta-1; Beta-1-adaptin; Beta-adaptin 1; Clathrin assembly protein complex 1 beta large chain; Golgi adaptor HA1/AP1 adaptin beta subunit", "protein_names_refseq": "AP-1 complex subunit beta-1; AP-2 complex subunit beta; AP105B; adapter-related protein complex 1 subunit beta-1; adapter-related protein complex 2 beta subunit; adapter-related protein complex 2 subunit beta; adaptor protein complex AP-1 subunit beta-1; adaptor protein complex AP-2 subunit beta; adaptor-related protein complex 1 subunit beta-1; adaptor-related protein complex 2 subunit beta; adaptor-related protein complex 2, beta 1 subunit; beta-1-adaptin; beta-2-adaptin; beta-adaptin 1; beta1-adaptin; beta2-adaptin; clathrin assembly protein complex 1 beta large chain; clathrin assembly protein complex 2 beta large chain; clathrin-associated / assembly / adaptor protein, large, beta 1; golgi adaptor HA1/AP1 adaptin beta subunit; plasma membrane adaptor HA2/AP2 adaptin beta subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:282183); (R-BTA-177504); (R-BTA-2132295); (R-BTA-416993); (R-BTA-437239); (R-BTA-5099900); (R-BTA-5140745); (R-BTA-8856825); (R-BTA-8856828); (R-BTA-8866427); (R-BTA-8964038)", "pathway_count": 11, "publication_count": 1, "publication_id_list": "1969413", "class_list": "", "function": "Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (By similarity). The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly (By similarity)., [UniProtKB, UniProtKB]; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030276 clathrin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0031410 cytoplasmic vesicle;GO:0030131 clathrin adaptor complex;GO:0012505 endomembrane system", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0016192 vesicle-mediated transport;GO:0098884 postsynaptic neurotransmitter receptor internalization;GO:0072583 clathrin-dependent endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08DS7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82931-1", "uniprot_id": [ { "id": "RT06_BOVIN", "url": "https://www.uniprot.org/uniprot/P82931", "type": "external" } ], "mass": 14148.0, "length": 124, "protein_name": "Small ribosomal subunit protein bS6m", "gene_name": "MRPS6", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein bS6m", "refseq_ac": [ { "id": "NP_001035674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035674", "type": "external" } ], "gene_names_uniprotkb": "MRPS6; RPMS6", "gene_names_refseq": "MRPS6", "protein_names_uniprotkb": "Small ribosomal subunit protein bS6m; 28S ribosomal protein S6, mitochondrial; MRP-S6; S6mt", "protein_names_refseq": "28S ribosomal protein S6, mitochondrial; MRP-S6; S6mt; small ribosomal subunit protein bS6m", "tax_id": 9913, "disease": "", "pathway": " (bta:615431); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "11279123;11402041;24799711", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZC18", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070181 small ribosomal subunit rRNA binding;GO:0019843 rRNA binding;GO:0005412 D-glucose:sodium symporter activity", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005743 mitochondrial inner membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0006412 translation;GO:0015798 myo-inositol transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P82931-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08E31-1", "uniprot_id": [ { "id": "CREST_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08E31", "type": "external" } ], "mass": 43329.0, "length": 402, "protein_name": "Calcium-responsive transactivator", "gene_name": "SS18L1", "organism": "Bovine", "refseq_name": "calcium-responsive transactivator", "refseq_ac": [ { "id": "NP_001071563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071563", "type": "external" } ], "gene_names_uniprotkb": "SS18L1; CREST", "gene_names_refseq": "SS18L1", "protein_names_uniprotkb": "Calcium-responsive transactivator; SS18-like protein 1", "protein_names_refseq": "SS18-like protein 1; SS18L1, nBAF chromatin remodeling complex subunit; calcium-responsive transactivator; synovial sarcoma translocation gene on chromosome 18-like 1", "tax_id": 9913, "disease": "", "pathway": " (bta:768207); (R-BTA-9933937); (R-BTA-9933947)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0071565 nBAF complex;GO:0000776 kinetochore", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0050775 positive regulation of dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08E31-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DA8-1", "uniprot_id": [ { "id": "ATF1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DA8", "type": "external" } ], "mass": 29261.0, "length": 270, "protein_name": "Cyclic AMP-dependent transcription factor ATF-1", "gene_name": "ATF1", "organism": "Bovine", "refseq_name": "cyclic AMP-dependent transcription factor ATF-1", "refseq_ac": [ { "id": "NP_001068757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068757", "type": "external" } ], "gene_names_uniprotkb": "ATF1", "gene_names_refseq": "ATF1", "protein_names_uniprotkb": "Cyclic AMP-dependent transcription factor ATF-1; Activating transcription factor 1; cAMP-dependent transcription factor ATF-1", "protein_names_refseq": "cAMP-dependent transcription factor ATF-1; cyclic AMP-dependent transcription factor ATF-1", "tax_id": 9913, "disease": "", "pathway": " (bta:506967); (R-BTA-199920)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "28198054", "class_list": "", "function": "The current data shows a timely GFP translation in bovine embryos depending on sequences in the 3'UTR of ATF1/2, and indicates a difference between short and long isoforms., [RefSeq, PubMed]; This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:1990589 ATF4-CREB1 transcription factor complex;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0141156 cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08DA8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DG6-1", "uniprot_id": [ { "id": "COX15_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DG6", "type": "external" } ], "mass": 46126.0, "length": 413, "protein_name": "Heme A synthase COX15", "gene_name": "COX15", "organism": "Bovine", "refseq_name": "heme A synthase COX15", "refseq_ac": [ { "id": "NP_001070329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070329", "type": "external" } ], "gene_names_uniprotkb": "COX15", "gene_names_refseq": "COX15; HAS", "protein_names_uniprotkb": "Heme A synthase COX15; 1.17.99.9; Cytochrome c oxidase assembly protein COX15 homolog; HAS", "protein_names_refseq": "COX15 homolog, cytochrome c oxidase assembly protein; COX15, cytochrome c oxidase assembly homolog; cytochrome c oxidase assembly protein COX15 homolog; heme A synthase COX15", "tax_id": 9913, "disease": "", "pathway": " (bta:517811); (R-BTA-189451); (R-BTA-9864848)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the second reaction in the biosynthesis of heme A, a prosthetic group of mitochondrial cytochrome c oxidase (CcO). Heme A is synthesized from heme B by two sequential enzymatic reactions catalyzed by heme O synthase (HOS) and heme A synthase (HAS). HAS catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8, in a reaction that involves matrix ferredoxin and ferredoxin reductase. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.9", "type": "external" }, { "id": "1.17.99.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.17.99.9", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0120547 heme A synthase activity;GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0005739 mitochondrion;GO:0070069 cytochrome complex", "go_biological_process": "GO:0006784 heme A biosynthetic process;GO:0017004 cytochrome complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DG6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DP2-1", "uniprot_id": [ { "id": "BORC5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DP2", "type": "external" } ], "mass": 22200.0, "length": 196, "protein_name": "BLOC-1-related complex subunit 5", "gene_name": "BORCS5", "organism": "Bovine", "refseq_name": "BLOC-1-related complex subunit 5", "refseq_ac": [ { "id": "NP_001069823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069823", "type": "external" } ], "gene_names_uniprotkb": "BORCS5", "gene_names_refseq": "BORCS5; LOH12CR1", "protein_names_uniprotkb": "BLOC-1-related complex subunit 5", "protein_names_refseq": "BLOC-1-related complex subunit 5; loss of heterozygosity 12 chromosomal region 1 protein homolog; loss of heterozygosity, 12, chromosomal region 1", "tax_id": 9913, "disease": "", "pathway": " (bta:614947)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Thereby, it may indirectly play a role in cell spreading and motility., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0030672 synaptic vesicle membrane;GO:0098574 cytoplasmic side of lysosomal membrane;GO:0099078 BORC complex;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0032418 lysosome localization;GO:0072384 organelle transport along microtubule;GO:1903744 positive regulation of anterograde synaptic vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DP2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DA5-1", "uniprot_id": [ { "id": "PANK3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DA5", "type": "external" } ], "mass": 41117.0, "length": 370, "protein_name": "Pantothenate kinase 3", "gene_name": "PANK3", "organism": "Bovine", "refseq_name": "pantothenate kinase 3", "refseq_ac": [ { "id": "NP_001068931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068931", "type": "external" } ], "gene_names_uniprotkb": "PANK3", "gene_names_refseq": "PANK3", "protein_names_uniprotkb": "Pantothenate kinase 3; 2.7.1.33; Pantothenic acid kinase 3", "protein_names_refseq": "pantothenate kinase 3; pantothenic acid kinase 3", "tax_id": 9913, "disease": "", "pathway": " (bta:510749); (R-BTA-196783)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.33", "type": "external" } ], "go_molecular_function": "GO:0019842 vitamin binding;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0004594 pantothenate kinase activity;GO:1905502 acetyl-CoA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0016310 phosphorylation;GO:0015937 coenzyme A biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DA5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5J9-1", "uniprot_id": [ { "id": "RPR1A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5J9", "type": "external" } ], "mass": 35720.0, "length": 312, "protein_name": "Regulation of nuclear pre-mRNA domain-containing protein 1A", "gene_name": "RPRD1A", "organism": "Bovine", "refseq_name": "regulation of nuclear pre-mRNA domain-containing protein 1A", "refseq_ac": [ { "id": "NP_001068624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068624", "type": "external" } ], "gene_names_uniprotkb": "RPRD1A; P15RS", "gene_names_refseq": "P15RS; RPRD1A", "protein_names_uniprotkb": "Regulation of nuclear pre-mRNA domain-containing protein 1A; Cyclin-dependent kinase inhibitor 2B-related protein; p15INK4B-related protein", "protein_names_refseq": "cyclin-dependent kinase 2B-inhibitor-related protein; cyclin-dependent kinase inhibitor 2B-related protein; p15INK4B-related protein; regulation of nuclear pre-mRNA domain-containing protein 1A", "tax_id": 9913, "disease": "", "pathway": " (bta:504355); (R-BTA-6807505)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0000993 RNA polymerase II complex binding;GO:0099122 RNA polymerase II C-terminal domain binding;GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0001111 RNA polymerase II promoter clearance;GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5J9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5B3-1", "uniprot_id": [ { "id": "RBTN1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5B3", "type": "external" } ], "mass": 17823.0, "length": 156, "protein_name": "Rhombotin-1", "gene_name": "LMO1", "organism": "Bovine", "refseq_name": "rhombotin-1", "refseq_ac": [ { "id": "NP_001069363", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069363", "type": "external" } ], "gene_names_uniprotkb": "LMO1; RBTN1", "gene_names_refseq": "LMO1", "protein_names_uniprotkb": "Rhombotin-1; LIM domain only protein 1; LMO-1", "protein_names_refseq": "LIM domain only 1 (rhombotin 1); LIM domain only protein 1; LMO-1; rhombotin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:527152); (R-BTA-8939236)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5B3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC74-1", "uniprot_id": [ { "id": "TMLH_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC74", "type": "external" } ], "mass": 49837.0, "length": 421, "protein_name": "Trimethyllysine dioxygenase, mitochondrial", "gene_name": "TMLHE", "organism": "Bovine", "refseq_name": "trimethyllysine dioxygenase, mitochondrial", "refseq_ac": [ { "id": "NP_001069532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069532", "type": "external" } ], "gene_names_uniprotkb": "TMLHE", "gene_names_refseq": "TMLHE", "protein_names_uniprotkb": "Trimethyllysine dioxygenase, mitochondrial; 1.14.11.8; Epsilon-trimethyllysine 2-oxoglutarate dioxygenase; TML dioxygenase; TML hydroxylase; TML-alpha-ketoglutarate dioxygenase; TMLD", "protein_names_refseq": "TML dioxygenase; TML hydroxylase; TML-alpha-ketoglutarate dioxygenase; TMLD; epsilon-trimethyllysine 2-oxoglutarate dioxygenase; trimethyllysine dioxygenase, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:535630); (R-BTA-71262)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML) in the carnitine biosynthesis pathway., [UniProtKB, UniProtKB]; Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.8", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0050353 trimethyllysine dioxygenase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0045329 carnitine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VC74-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIF0-1", "uniprot_id": [ { "id": "ILKAP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIF0", "type": "external" } ], "mass": 40622.0, "length": 370, "protein_name": "Integrin-linked kinase-associated serine/threonine phosphatase 2C", "gene_name": "ILKAP", "organism": "Bovine", "refseq_name": "integrin-linked kinase-associated serine/threonine phosphatase 2C", "refseq_ac": [ { "id": "NP_001069123", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069123", "type": "external" } ], "gene_names_uniprotkb": "ILKAP", "gene_names_refseq": "ILKAP", "protein_names_uniprotkb": "Integrin-linked kinase-associated serine/threonine phosphatase 2C; 3.1.3.16; ILKAP", "protein_names_refseq": "integrin-linked kinase-associated protein phosphatase 2C; integrin-linked kinase-associated serine/threonine phosphatase 2C", "tax_id": 9913, "disease": "", "pathway": " (bta:514223)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0IIF0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0III9-1", "uniprot_id": [ { "id": "ACTN3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0III9", "type": "external" } ], "mass": 103151.0, "length": 901, "protein_name": "Alpha-actinin-3", "gene_name": "ACTN3", "organism": "Bovine", "refseq_name": "alpha-actinin-3", "refseq_ac": [ { "id": "NP_001069625", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069625", "type": "external" } ], "gene_names_uniprotkb": "ACTN3", "gene_names_refseq": "ACTN3", "protein_names_uniprotkb": "Alpha-actinin-3; Alpha-actinin skeletal muscle isoform 3; F-actin cross-linking protein", "protein_names_refseq": "F-actin cross-linking protein; alpha-actinin skeletal muscle; alpha-actinin-3", "tax_id": 9913, "disease": "", "pathway": " (bta:539375); (R-BTA-390522)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005903 brush border;GO:0005925 focal adhesion;GO:0030054 cell junction;GO:0030018 Z disc", "go_biological_process": "GO:1901078 negative regulation of relaxation of muscle;GO:0030036 actin cytoskeleton organization;GO:0014728 regulation of the force of skeletal muscle contraction;GO:0014732 skeletal muscle atrophy;GO:0014883 transition between fast and slow fiber", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0III9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DE6-1", "uniprot_id": [ { "id": "AQP3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DE6", "type": "external" } ], "mass": 31518.0, "length": 292, "protein_name": "Aquaporin-3", "gene_name": "AQP3", "organism": "Bovine", "refseq_name": "aquaporin-3", "refseq_ac": [ { "id": "NP_001073262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073262", "type": "external" } ], "gene_names_uniprotkb": "AQP3", "gene_names_refseq": "AQP3", "protein_names_uniprotkb": "Aquaporin-3; AQP-3; Aquaglyceroporin-3", "protein_names_refseq": "AQP-3; aquaglyceroporin-3; aquaporin 3 (Gill blood group); aquaporin-3", "tax_id": 9913, "disease": "", "pathway": " (bta:780866); (R-BTA-432040); (R-BTA-432047)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "21527251;24812069;27221122;29798965", "class_list": "", "function": "Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (By similarity). Could also be permeable to urea (By similarity). Also participates in cell permeability to H2O2 and H2O2-mediated signaling (By similarity). In skin, transports glycerol to the epidermis and stratum corneum, where it maintains hydration, elasticity, and supports lipid biosynthesis for barrier repair. In kidney, contributes to the reabsorption of water, helping the body maintain proper fluid balance (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data suggest that AQP3 is localized to mid-piece of bull spermatozoa; AQP7 is localized to mid-piece and post-acrosomal region of bull spermatozoa. Neither relative abundance of AQP3 or AQP7 nor their localization patterns is altered by cryopreservation; individual differences between bull ejaculates appear to be common. Abundance of AQP7 is higher in ejaculates with good versus poor freezability in cryopreservation., [RefSeq, PubMed]; Data suggest that expression of AQP3 (aquaglyceroporin-3) in rumen mucosa can be modulated by dietary factors; here, AQP3 and UT-B (urea transporter B) expression are upregulated with solid food intake (low-protein diet of plant forage) at weaning., [RefSeq, PubMed]; Lack of AQP3 in bovine erythrocytes points to the lipid pathway as responsible for glycerol permeation and explains the low glycerol permeability and high E(a) for transport observed in ruminants., [RefSeq, PubMed]; Our findings suggest that AQP3 and AQP7 are possibly involved in the tolerance to freeze-thawing in bull spermatozoa, particularly in the sperm's tail., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0015250 water channel activity;GO:0015254 glycerol channel activity;GO:0015166 polyol transmembrane transporter activity;GO:0015204 urea transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0032526 response to retinoic acid;GO:0042476 odontogenesis;GO:0006833 water transport;GO:0015793 glycerol transmembrane transport;GO:0015791 polyol transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q08DE6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82923-1", "uniprot_id": [ { "id": "RT02_BOVIN", "url": "https://www.uniprot.org/uniprot/P82923", "type": "external" } ], "mass": 31729.0, "length": 293, "protein_name": "Small ribosomal subunit protein uS2m", "gene_name": "MRPS2", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein uS2m", "refseq_ac": [ { "id": "NP_001092347", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092347", "type": "external" } ], "gene_names_uniprotkb": "MRPS2", "gene_names_refseq": "MRPS2", "protein_names_uniprotkb": "Small ribosomal subunit protein uS2m; 28S ribosomal protein S2, mitochondrial; MRP-S2; S2mt", "protein_names_refseq": "28S ribosomal protein S2, mitochondrial; MRP-S2; S2mt; small ribosomal subunit protein uS2m", "tax_id": 9913, "disease": "", "pathway": " (bta:505681); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9837999); (R-BTA-9937383)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "11279123;24799711", "class_list": "", "function": "Required for mitoribosome formation and stability, and mitochondrial translation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6H6X0", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0061668 mitochondrial ribosome assembly;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P82923-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82927-1", "uniprot_id": [ { "id": "RM42_BOVIN", "url": "https://www.uniprot.org/uniprot/P82927", "type": "external" } ], "mass": 16637.0, "length": 142, "protein_name": "Large ribosomal subunit protein mL42", "gene_name": "MRPL42", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein mL42 precursor", "refseq_ac": [ { "id": "NP_001032711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032711", "type": "external" } ], "gene_names_uniprotkb": "MRPL42; MRPS32", "gene_names_refseq": "MRPL42", "protein_names_uniprotkb": "Large ribosomal subunit protein mL42; 28S ribosomal protein S32, mitochondrial; 39S ribosomal protein L42, mitochondrial; L42mt; MRP-L42; MRP-S32; S32mt", "protein_names_refseq": "28S ribosomal protein L42, mitochondrial; 28S ribosomal protein S32, mitochondrial; 39S ribosomal protein L42, mitochondrial; L42mt; MRP-L42; MRP-S32; S32mt; large ribosomal subunit protein mL42 precursor; large ribosomal subunit protein mL42", "tax_id": 9913, "disease": "", "pathway": " (bta:614148); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "11279123", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32LA9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005763 mitochondrial small ribosomal subunit;GO:0005743 mitochondrial inner membrane;GO:0005739 mitochondrion;GO:0005840 ribosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P82927-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08E24-1", "uniprot_id": [ { "id": "SARAF_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08E24", "type": "external" } ], "mass": 36314.0, "length": 335, "protein_name": "Store-operated calcium entry-associated regulatory factor", "gene_name": "SARAF", "organism": "Bovine", "refseq_name": "store-operated calcium entry-associated regulatory factor precursor", "refseq_ac": [ { "id": "NP_001070324", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070324", "type": "external" } ], "gene_names_uniprotkb": "SARAF; TMEM66", "gene_names_refseq": "SARAF; TMEM66", "protein_names_uniprotkb": "Store-operated calcium entry-associated regulatory factor; SARAF; SOCE-associated regulatory factor; Transmembrane protein 66", "protein_names_refseq": "SOCE-associated regulatory factor; store-operated calcium entry-associated regulatory factor precursor; transmembrane protein 66", "tax_id": 9913, "disease": "", "pathway": " (bta:515461)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0140268 endoplasmic reticulum-plasma membrane contact site", "go_biological_process": "GO:0006816 calcium ion transport;GO:2001256 regulation of store-operated calcium entry", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08E24-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5N1-1", "uniprot_id": [ { "id": "CNPY3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5N1", "type": "external" } ], "mass": 31388.0, "length": 282, "protein_name": "Protein canopy homolog 3", "gene_name": "CNPY3", "organism": "Bovine", "refseq_name": "protein canopy homolog 3 precursor", "refseq_ac": [ { "id": "NP_001068907", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068907", "type": "external" } ], "gene_names_uniprotkb": "CNPY3", "gene_names_refseq": "CNPY3", "protein_names_uniprotkb": "Protein canopy homolog 3", "protein_names_refseq": "canopy 3 homolog; protein canopy homolog 3 precursor; protein canopy homolog 3", "tax_id": 9913, "disease": "", "pathway": " (bta:510220); (R-BTA-1679131)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5N1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC54-1", "uniprot_id": [ { "id": "ZNT6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC54", "type": "external" } ], "mass": 50932.0, "length": 461, "protein_name": "Zinc transporter 6", "gene_name": "SLC30A6", "organism": "Bovine", "refseq_name": "zinc transporter 6", "refseq_ac": [ { "id": "NP_001069234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069234", "type": "external" } ], "gene_names_uniprotkb": "SLC30A6; ZNT6", "gene_names_refseq": "SLC30A6", "protein_names_uniprotkb": "Zinc transporter 6; Solute carrier family 30 member 6; ZnT-6", "protein_names_refseq": "solute carrier family 30 (zinc transporter), member 6; zinc transporter 6; znT-6", "tax_id": 9913, "disease": "", "pathway": " (bta:518111)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway. As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0032588 trans-Golgi network membrane;GO:0016324 apical plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006829 zinc ion transport;GO:0071579 regulation of zinc ion transport;GO:1904257 zinc ion import into Golgi lumen", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VC54-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5K1-1", "uniprot_id": [ { "id": "GPBP1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5K1", "type": "external" } ], "mass": 53420.0, "length": 473, "protein_name": "Vasculin", "gene_name": "GPBP1", "organism": "Bovine", "refseq_name": "vasculin", "refseq_ac": [ { "id": "NP_001069755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069755", "type": "external" } ], "gene_names_uniprotkb": "GPBP1", "gene_names_refseq": "GPBP1", "protein_names_uniprotkb": "Vasculin; GC-rich promoter-binding protein 1", "protein_names_refseq": "vasculin", "tax_id": 9913, "disease": "", "pathway": " (bta:613751)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a GC-rich promoter-specific transactivating transcription factor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5K1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05B83-1", "uniprot_id": [ { "id": "RFC2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05B83", "type": "external" } ], "mass": 38730.0, "length": 352, "protein_name": "Replication factor C subunit 2", "gene_name": "RFC2", "organism": "Bovine", "refseq_name": "replication factor C subunit 2", "refseq_ac": [ { "id": "NP_001074372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074372", "type": "external" } ], "gene_names_uniprotkb": "RFC2", "gene_names_refseq": "RFC2", "protein_names_uniprotkb": "Replication factor C subunit 2; Activator 1 subunit 2", "protein_names_refseq": "activator 1 subunit 2; replication factor C (activator 1) 2, 40kDa; replication factor C subunit 2", "tax_id": 9913, "disease": "", "pathway": " (bta:508652); (R-BTA-110312); (R-BTA-110314); (R-BTA-110320); (R-BTA-174411); (R-BTA-176187); (R-BTA-5651801); (R-BTA-5655862); (R-BTA-5656121); (R-BTA-5656169); (R-BTA-5685938); (R-BTA-5685942); (R-BTA-5693537); (R-BTA-5693607); (R-BTA-5696397); (R-BTA-5696400); (R-BTA-6782135); (R-BTA-6782210); (R-BTA-6804756); (R-BTA-69091); (R-BTA-69473)", "pathway_count": 21, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA (By similarity). This subunit binds ATP (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0019899 enzyme binding;GO:0003689 DNA clamp loader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031390 Ctf18 RFC-like complex;GO:0005663 DNA replication factor C complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006281 DNA repair;GO:1900264 positive regulation of DNA-directed DNA polymerase activity;GO:0006261 DNA-templated DNA replication;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q05B83-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC58-1", "uniprot_id": [ { "id": "TM38B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC58", "type": "external" } ], "mass": 32451.0, "length": 291, "protein_name": "Trimeric intracellular cation channel type B", "gene_name": "TMEM38B", "organism": "Bovine", "refseq_name": "trimeric intracellular cation channel type B", "refseq_ac": [ { "id": "NP_001069855", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069855", "type": "external" } ], "gene_names_uniprotkb": "TMEM38B", "gene_names_refseq": "TMEM38B", "protein_names_uniprotkb": "Trimeric intracellular cation channel type B; TRIC-B; TRICB; Transmembrane protein 38B", "protein_names_refseq": "TRIC-B; TRICB; trimeric intracellular cation channel type B", "tax_id": 9913, "disease": "", "pathway": " (bta:615646)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Intracellular monovalent cation channel required for maintenance of rapid intracellular calcium release. Acts as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. Activated by increased cytosolic Ca(2+) levels., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005267 potassium channel activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0051279 regulation of release of sequestered calcium ion into cytosol;GO:0071805 potassium ion transmembrane transport;GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VC58-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84081-1", "uniprot_id": [ { "id": "ARF2_BOVIN", "url": "https://www.uniprot.org/uniprot/P84081", "type": "external" } ], "mass": 20746.0, "length": 181, "protein_name": "ADP-ribosylation factor 2", "gene_name": "ARF2", "organism": "Bovine", "refseq_name": "ADP-ribosylation factor 2", "refseq_ac": [ { "id": "NP_777114", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777114", "type": "external" } ], "gene_names_uniprotkb": "ARF2", "gene_names_refseq": "ARF2", "protein_names_uniprotkb": "ADP-ribosylation factor 2", "protein_names_refseq": "ADP-ribosylation factor 2", "tax_id": 9913, "disease": "", "pathway": " (bta:282601)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "3135549;8444865", "class_list": "", "function": "GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4FUC3;P10947;P16500", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P84081-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5I6-1", "uniprot_id": [ { "id": "PR38A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5I6", "type": "external" } ], "mass": 37477.0, "length": 312, "protein_name": "Pre-mRNA-splicing factor 38A", "gene_name": "PRPF38A", "organism": "Bovine", "refseq_name": "pre-mRNA-splicing factor 38A", "refseq_ac": [ { "id": "NP_001068775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068775", "type": "external" } ], "gene_names_uniprotkb": "PRPF38A", "gene_names_refseq": "PRPF38A", "protein_names_uniprotkb": "Pre-mRNA-splicing factor 38A", "protein_names_refseq": "PRP38 pre-mRNA processing factor 38 domain containing A; pre-mRNA-splicing factor 38A", "tax_id": 9913, "disease": "", "pathway": " (bta:507240); (R-BTA-72163)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in pre-mRNA splicing as a component of the spliceosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0071011 precatalytic spliceosome;GO:0071005 U2-type precatalytic spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5I6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIC2-1", "uniprot_id": [ { "id": "KLD10_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIC2", "type": "external" } ], "mass": 49111.0, "length": 442, "protein_name": "Kelch domain-containing protein 10", "gene_name": "KLHDC10", "organism": "Bovine", "refseq_name": "kelch domain-containing protein 10", "refseq_ac": [ { "id": "NP_001068695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068695", "type": "external" } ], "gene_names_uniprotkb": "KLHDC10", "gene_names_refseq": "KLHDC10", "protein_names_uniprotkb": "Kelch domain-containing protein 10", "protein_names_refseq": "kelch domain-containing protein 10", "tax_id": 9913, "disease": "", "pathway": " (bta:505844); (R-BTA-9954709)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C-terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). The CRL2(KLHDC10) complex specifically recognizes proteins with a proline-glycine (Pro-Gly) or an alanine tail (CAT tail) at the C-terminus, leading to their ubiquitination and degradation (By similarity). The CRL2(KLHDC10) complex is involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: CRL2(KLHDC10) acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation (By similarity). Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5 (By similarity). Acts as a regulator of necroptosis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0016567 protein ubiquitination;GO:0032874 positive regulation of stress-activated MAPK cascade;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0IIC2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DM8-1", "uniprot_id": [ { "id": "TSN_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DM8", "type": "external" } ], "mass": 26169.0, "length": 228, "protein_name": "Translin", "gene_name": "TSN", "organism": "Bovine", "refseq_name": "translin", "refseq_ac": [ { "id": "NP_001068890", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068890", "type": "external" } ], "gene_names_uniprotkb": "TSN", "gene_names_refseq": "C3PO; TSN", "protein_names_uniprotkb": "Translin; 3.1.-.-; C3PO; Component 3 of promoter of RISC", "protein_names_refseq": "component 3 of promoter of RISC; translin", "tax_id": 9913, "disease": "", "pathway": " (bta:509943); (R-BTA-426486)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L5B5", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0016787 hydrolase activity;GO:0042802 identical protein binding;GO:0004519 endonuclease activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0030422 siRNA processing;GO:0016070 RNA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08DM8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0GBZ5-1", "uniprot_id": [ { "id": "OX1R_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0GBZ5", "type": "external" } ], "mass": 47756.0, "length": 425, "protein_name": "Orexin/Hypocretin receptor type 1", "gene_name": "HCRTR1", "organism": "Bovine", "refseq_name": "orexin/Hypocretin receptor type 1", "refseq_ac": [ { "id": "NP_001041647", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001041647", "type": "external" } ], "gene_names_uniprotkb": "HCRTR1", "gene_names_refseq": "HCRTR1", "protein_names_uniprotkb": "Orexin/Hypocretin receptor type 1", "protein_names_refseq": "hypocretin (orexin) receptor 1; hypocretin receptor type 1; orexin receptor 1; orexin receptor type 1; orexin/Hypocretin receptor type 1; ox-1-R; ox1-R; ox1r", "tax_id": 9913, "disease": "", "pathway": " (bta:282248); (R-BTA-389397); (R-BTA-416476)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "18213704;19089887;23635422", "class_list": "", "function": "First evidence for the expression of oxA and ox1R in the vestibular glands of mammalian genital tract, [RefSeq, PubMed]; G protein-coupled receptor that binds the neuropeptide orexin-A with high affinity, and orexin-B with lower affinity, two peptides derived from a common precursor, prepro-orexin. Its activity is mediated via a G(q)-protein-coupled pathway, which activates the phosphatidylinositol-calcium second messenger system in response to orexin-A binding. In addition to G(q)-mediated signaling, orexin-A stimulation also promotes beta-arrestin recruitment, leading to receptor internalization (By similarity). Plays a significant role in the regulation of food intake (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Locally synthesized in the urethroprostatic complex, [RefSeq, PubMed]; These data confirmed expression of orexin and its two receptors in the bovine adrenal gland., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0016499 orexin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0032870 cellular response to hormone stimulus;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0007631 feeding behavior", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q0GBZ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V7M4-1", "uniprot_id": [ { "id": "SCMC2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V7M4", "type": "external" } ], "mass": 52769.0, "length": 469, "protein_name": "Mitochondrial adenyl nucleotide antiporter SLC25A25", "gene_name": "SLC25A25", "organism": "Bovine", "refseq_name": "mitochondrial adenyl nucleotide antiporter SLC25A25", "refseq_ac": [ { "id": "NP_001033234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033234", "type": "external" } ], "gene_names_uniprotkb": "SLC25A25; SCAMC2", "gene_names_refseq": "SLC25A25", "protein_names_uniprotkb": "Mitochondrial adenyl nucleotide antiporter SLC25A25; Calcium-binding mitochondrial carrier protein SCaMC-2; Mitochondrial ATP-Mg/Pi carrier protein 3; Short calcium-binding mitochondrial carrier protein 2; Solute carrier family 25 member 25", "protein_names_refseq": "calcium-binding mitochondrial carrier protein SCaMC-2; mitochondrial ATP-Mg/Pi carrier protein 3; mitochondrial adenyl nucleotide antiporter SLC25A25; short calcium-binding mitochondrial carrier protein 2; small calcium-binding mitochondrial carrier protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:527786)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Electroneutral antiporter that most probably mediates the transport of adenyl nucleotides through the inner mitochondrial membrane. Has calcium-dependent ATP-magnesium/inorganic phosphate antiporter activity. Could also have a broader specificity for adenyl nucleotides. By regulating the mitochondrial matrix adenyl nucleotide pool, could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways. Acts downstream of Ca(2+)-permeable cation channel PKD2/TRPP2 and it is likely that PKD2-mediated Ca(2+) signaling activates SLC25A25 antiporter activity. Required for left-right pattern specification., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32PJ0", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0005509 calcium ion binding;GO:0015297 antiporter activity;GO:0005347 ATP transmembrane transporter activity;GO:0140987 ATP:phosphate antiporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0015866 ADP transport;GO:0015867 ATP transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0V7M4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0II25-1", "uniprot_id": [ { "id": "POP7_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0II25", "type": "external" } ], "mass": 15707.0, "length": 140, "protein_name": "Ribonuclease P protein subunit p20", "gene_name": "POP7", "organism": "Bovine", "refseq_name": "ribonuclease P protein subunit p20", "refseq_ac": [ { "id": "NP_001069950", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069950", "type": "external" } ], "gene_names_uniprotkb": "POP7; RPP20", "gene_names_refseq": "POP7", "protein_names_uniprotkb": "Ribonuclease P protein subunit p20; RNaseP protein p20", "protein_names_refseq": "RNaseP protein p20; processing of precursor 7, ribonuclease P/MRP subunit; ribonuclease P protein subunit p20", "tax_id": 9913, "disease": "", "pathway": " (bta:617906)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0033204 ribonuclease P RNA binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0030681 multimeric ribonuclease P complex;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0008033 tRNA processing;GO:0006364 rRNA processing;GO:0001682 tRNA 5'-leader removal", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0II25-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82670-1", "uniprot_id": [ { "id": "RT10_BOVIN", "url": "https://www.uniprot.org/uniprot/P82670", "type": "external" } ], "mass": 23032.0, "length": 201, "protein_name": "Small ribosomal subunit protein uS10m", "gene_name": "MRPS10", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein uS10m", "refseq_ac": [ { "id": "NP_001030391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030391", "type": "external" } ], "gene_names_uniprotkb": "MRPS10", "gene_names_refseq": "MRPS10", "protein_names_uniprotkb": "Small ribosomal subunit protein uS10m; 28S ribosomal protein S10, mitochondrial; MRP-S10; S10mt", "protein_names_refseq": "28S ribosomal protein S10, mitochondrial; MRP-S10; S10mt; small ribosomal subunit protein uS10m", "tax_id": 9913, "disease": "", "pathway": " (bta:515885); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9837999); (R-BTA-9937383)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "10938081;24799711", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZF4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P82670-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P571-1", "uniprot_id": [ { "id": "MLRS_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P571", "type": "external" } ], "mass": 19013.0, "length": 170, "protein_name": "Myosin regulatory light chain 2, skeletal muscle isoform", "gene_name": "MYL11; MYLPF", "organism": "Bovine", "refseq_name": "myosin regulatory light chain 2, skeletal muscle isoform", "refseq_ac": [ { "id": "NP_001069115", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069115", "type": "external" } ], "gene_names_uniprotkb": "MYL11; MYLPF", "gene_names_refseq": "MYL11; MYLPF", "protein_names_uniprotkb": "Myosin regulatory light chain 2, skeletal muscle isoform; Fast skeletal myosin light chain 2; MLC2F", "protein_names_refseq": "MLC2F; fast skeletal myosin light chain 2; myosin light chain, phosphorylatable, fast skeletal muscle; myosin regulatory light chain 2, skeletal muscle isoform", "tax_id": 9913, "disease": "", "pathway": " (bta:514106); (R-BTA-445355)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in muscle contraction., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008307 structural constituent of muscle", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016459 myosin complex", "go_biological_process": "GO:0006936 muscle contraction;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P571-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05B73-1", "uniprot_id": [ { "id": "S35A4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05B73", "type": "external" } ], "mass": 34540.0, "length": 324, "protein_name": "Probable UDP-sugar transporter protein SLC35A4", "gene_name": "SLC35A4", "organism": "Bovine", "refseq_name": "probable UDP-sugar transporter protein SLC35A4", "refseq_ac": [ { "id": "NP_001073080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073080", "type": "external" } ], "gene_names_uniprotkb": "SLC35A4; LOC112447523", "gene_names_refseq": "SLC35A4", "protein_names_uniprotkb": "Probable UDP-sugar transporter protein SLC35A4; Solute carrier family 35 member A4", "protein_names_refseq": "probable UDP-sugar transporter protein SLC35A4", "tax_id": 9913, "disease": "", "pathway": " (bta:539354)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mediates the transport of CDP-ribitol (By similarity). Does not exhibit CMP-sialic acid, UDP-galactose and UDP-N-acetylglucosamine transport activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q05B73-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V8G8-1", "uniprot_id": [ { "id": "ZBTB6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V8G8", "type": "external" } ], "mass": 48510.0, "length": 424, "protein_name": "Zinc finger and BTB domain-containing protein 6", "gene_name": "ZBTB6", "organism": "Bovine", "refseq_name": "zinc finger and BTB domain-containing protein 6", "refseq_ac": [ { "id": "NP_001069675", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069675", "type": "external" } ], "gene_names_uniprotkb": "ZBTB6; ZNF482", "gene_names_refseq": "ZBTB6; ZNF482", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 6; Zinc finger protein 482", "protein_names_refseq": "zinc finger and BTB domain-containing protein 6; zinc finger protein 482", "tax_id": 9913, "disease": "", "pathway": " (bta:540218)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0002682 regulation of immune system process;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0V8G8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DN7-1", "uniprot_id": [ { "id": "VAV_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DN7", "type": "external" } ], "mass": 98243.0, "length": 844, "protein_name": "Proto-oncogene vav", "gene_name": "VAV1", "organism": "Bovine", "refseq_name": "proto-oncogene vav", "refseq_ac": [ { "id": "NP_001071542", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071542", "type": "external" } ], "gene_names_uniprotkb": "VAV1", "gene_names_refseq": "VAV1", "protein_names_uniprotkb": "Proto-oncogene vav", "protein_names_refseq": "proto-oncogene vav; vav 1 guanine nucleotide exchange factor; vav 1 oncogene", "tax_id": 9913, "disease": "", "pathway": " (bta:617345); (R-BTA-114604); (R-BTA-1257604); (R-BTA-1433557); (R-BTA-2029482); (R-BTA-2871796); (R-BTA-2871809); (R-BTA-389359); (R-BTA-416482); (R-BTA-4420097); (R-BTA-512988); (R-BTA-6811558); (R-BTA-8980692); (R-BTA-9013404); (R-BTA-9013408); (R-BTA-9027284); (R-BTA-912631); (R-BTA-983695)", "pathway_count": 18, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0008270 zinc ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0140031 phosphorylation-dependent protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005911 cell-cell junction", "go_biological_process": "GO:0016477 cell migration;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0031295 T cell costimulation;GO:0007264 small GTPase-mediated signal transduction;GO:0030101 natural killer cell activation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DN7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5M8-1", "uniprot_id": [ { "id": "MPPA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5M8", "type": "external" } ], "mass": 58135.0, "length": 525, "protein_name": "Mitochondrial-processing peptidase subunit alpha", "gene_name": "PMPCA", "organism": "Bovine", "refseq_name": "mitochondrial-processing peptidase subunit alpha precursor", "refseq_ac": [ { "id": "NP_001070432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070432", "type": "external" } ], "gene_names_uniprotkb": "PMPCA", "gene_names_refseq": "PMPCA", "protein_names_uniprotkb": "Mitochondrial-processing peptidase subunit alpha; Alpha-MPP; Inactive zinc metalloprotease alpha", "protein_names_refseq": "alpha-MPP; inactive zinc metalloprotease alpha; mitochondrial-processing peptidase subunit alpha precursor; mitochondrial-processing peptidase subunit alpha; peptidase (mitochondrial processing) alpha; peptidase, mitochondrial processing alpha subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:767847); (R-BTA-8949664); (R-BTA-9837999)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "41018975", "class_list": "", "function": "Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0017087 mitochondrial processing peptidase complex;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016485 protein processing;GO:0006627 protein processing involved in protein targeting to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q0P5M8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V7M0-1", "uniprot_id": [ { "id": "IMA7_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V7M0", "type": "external" } ], "mass": 59881.0, "length": 536, "protein_name": "Importin subunit alpha-7", "gene_name": "KPNA6", "organism": "Bovine", "refseq_name": "importin subunit alpha-7", "refseq_ac": [ { "id": "NP_001069422", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069422", "type": "external" } ], "gene_names_uniprotkb": "KPNA6; IPOA7", "gene_names_refseq": "KPNA6", "protein_names_uniprotkb": "Importin subunit alpha-7; Karyopherin subunit alpha-6", "protein_names_refseq": "importin subunit alpha-7; karyopherin alpha 6 (importin alpha 7)", "tax_id": 9913, "disease": "", "pathway": " (bta:531602); (R-BTA-68616)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16305752;19420384;30053654", "class_list": "", "function": "Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity)., [UniProtKB]; Functions in nuclear protein import., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0042564 NLS-dependent protein nuclear import complex", "go_biological_process": "GO:0006607 NLS-bearing protein import into nucleus;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q0V7M0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCH4-1", "uniprot_id": [ { "id": "G3ST3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCH4", "type": "external" } ], "mass": 48699.0, "length": 427, "protein_name": "Galactose-3-O-sulfotransferase 3", "gene_name": "GAL3ST3", "organism": "Bovine", "refseq_name": "galactose-3-O-sulfotransferase 3", "refseq_ac": [ { "id": "NP_001069308", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069308", "type": "external" } ], "gene_names_uniprotkb": "GAL3ST3", "gene_names_refseq": "GAL3ST3", "protein_names_uniprotkb": "Galactose-3-O-sulfotransferase 3; 2.8.2.-; Beta-galactose-3-O-sulfotransferase 3; Gal-beta-1, 3-GalNAc 3'-sulfotransferase 3; Gal3ST-3", "protein_names_refseq": "beta-galactose-3-O-sulfotransferase 3; gal-beta-1, 3-GalNAc 3'-sulfotransferase 3; gal3ST-3; galactose-3-O-sulfotransferase 3", "tax_id": 9913, "disease": "", "pathway": " (bta:523401)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the transfer of a sulfate group from 3'-phosphoadenylyl sulfate (PAPS) to the C-3 hydroxyl group of terminal non-reducing beta-1,4-linked galactose residues in both N-glycans and O-glycans. It acts efficiently on type 2 chains (Gal-beta-1,4-GlcNAc-R) found in N-glycans and core 2-branched O-glycans (Gal-beta-1,4-GlcNAc-beta-1,6(Gal-beta-1,3)GalNAc-R). In contrast, it shows poor activity on type 1 chains (Gal-beta-1,3-GlcNAc-R) and intermediate activity on core 1 structures (Gal-beta-1,3-GalNAc-R). Participates in the glycoconjugates sulfation namely the 3'-sulfated Lewis X epitope (Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc), by sulfating N-acetyllactosamine (Gal-beta-1,4-GlcNAc) at the 3' position; then the resulting modification is fucosylated by FUT5., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050694 galactose 3-O-sulfotransferase activity;GO:0001733 galactosylceramide sulfotransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0009247 glycolipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCH4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DG8-1", "uniprot_id": [ { "id": "ZN135_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DG8", "type": "external" } ], "mass": 73944.0, "length": 657, "protein_name": "Zinc finger protein 135", "gene_name": "ZNF135", "organism": "Bovine", "refseq_name": "zinc finger protein 135", "refseq_ac": [ { "id": "NP_001070284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070284", "type": "external" } ], "gene_names_uniprotkb": "ZNF135", "gene_names_refseq": "ZNF135", "protein_names_uniprotkb": "Zinc finger protein 135", "protein_names_refseq": "zinc finger protein 135", "tax_id": 9913, "disease": "", "pathway": " (bta:508062); (R-BTA-212436)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation (Probable). Required for regulation of cell morphology and cytoskeletal organization (By similarity)., [UniProtKB, UniProtKB]; Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0022603 regulation of anatomical structure morphogenesis;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DG8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5L7-1", "uniprot_id": [ { "id": "GLMP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5L7", "type": "external" } ], "mass": 43531.0, "length": 404, "protein_name": "Glycosylated lysosomal membrane protein", "gene_name": "GLMP", "organism": "Bovine", "refseq_name": "glycosylated lysosomal membrane protein precursor", "refseq_ac": [ { "id": "NP_001098946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098946", "type": "external" } ], "gene_names_uniprotkb": "GLMP", "gene_names_refseq": "C1orf85; C3H1orf85; GLMP", "protein_names_uniprotkb": "Glycosylated lysosomal membrane protein; Lysosomal protein NCU-G1", "protein_names_refseq": "glycosylated lysosomal membrane protein precursor; lysosomal protein NCU-G1", "tax_id": 9913, "disease": "", "pathway": " (bta:100125876)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016020 membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050821 protein stabilization;GO:0061462 protein localization to lysosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5L7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5A5-1", "uniprot_id": [ { "id": "CKS1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5A5", "type": "external" } ], "mass": 9660.0, "length": 79, "protein_name": "Cyclin-dependent kinases regulatory subunit 1", "gene_name": "CKS1B", "organism": "Bovine", "refseq_name": "cyclin-dependent kinases regulatory subunit 1", "refseq_ac": [ { "id": "NP_001106782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106782", "type": "external" } ], "gene_names_uniprotkb": "CKS1B; CKS1", "gene_names_refseq": "CKS-1; CKS1B; CKS1; Sid 1334", "protein_names_uniprotkb": "Cyclin-dependent kinases regulatory subunit 1; CKS-1", "protein_names_refseq": "CDC28 protein kinase 1B; CDC28 protein kinase regulatory subunit 1; cyclin-dependent kinases regulatory subunit 1", "tax_id": 9913, "disease": "", "pathway": " (bta:615827); (R-BTA-187577); (R-BTA-69231)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042393 histone binding;GO:0043130 ubiquitin binding;GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5A5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIM3-1", "uniprot_id": [ { "id": "HS105_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIM3", "type": "external" } ], "mass": 96726.0, "length": 859, "protein_name": "Heat shock protein 105 kDa", "gene_name": "HSPH1", "organism": "Bovine", "refseq_name": "heat shock protein 105 kDa", "refseq_ac": [ { "id": "NP_001068770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068770", "type": "external" } ], "gene_names_uniprotkb": "HSPH1", "gene_names_refseq": "HSPH1", "protein_names_uniprotkb": "Heat shock protein 105 kDa; Heat shock 110 kDa protein", "protein_names_refseq": "heat shock 105kDa/110kDa protein 1; heat shock 110 kDa protein; heat shock protein 105 kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:507165); (R-BTA-3371453)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0000774 adenyl-nucleotide exchange factor activity;GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005654 nucleoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0051135 positive regulation of NK T cell activation;GO:0006457 protein folding;GO:0006986 response to unfolded protein;GO:0045345 positive regulation of MHC class I biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0IIM3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5N5-1", "uniprot_id": [ { "id": "GRPE2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5N5", "type": "external" } ], "mass": 25120.0, "length": 224, "protein_name": "GrpE protein homolog 2, mitochondrial", "gene_name": "GRPEL2", "organism": "Bovine", "refseq_name": "grpE protein homolog 2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001069142", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069142", "type": "external" } ], "gene_names_uniprotkb": "GRPEL2", "gene_names_refseq": "GRPEL2", "protein_names_uniprotkb": "GrpE protein homolog 2, mitochondrial; Mt-GrpE#2", "protein_names_refseq": "grpE protein homolog 2, mitochondrial precursor; grpE protein homolog 2, mitochondrial; mt-GrpE#2", "tax_id": 9913, "disease": "", "pathway": " (bta:514599)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0001405 PAM complex, Tim23 associated import motor;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006457 protein folding;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5N5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCA1-1", "uniprot_id": [ { "id": "DCE1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCA1", "type": "external" } ], "mass": 66784.0, "length": 594, "protein_name": "Glutamate decarboxylase 1", "gene_name": "GAD1", "organism": "Bovine", "refseq_name": "glutamate decarboxylase 1", "refseq_ac": [ { "id": "NP_001069224", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069224", "type": "external" } ], "gene_names_uniprotkb": "GAD1", "gene_names_refseq": "GAD1", "protein_names_uniprotkb": "Glutamate decarboxylase 1; 4.1.1.15", "protein_names_refseq": "glutamate decarboxylase 1 (brain, 67kDa); glutamate decarboxylase 1; glutamic acid decarboxylase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:517552); (R-BTA-888568); (R-BTA-888590)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "19728158", "class_list": "", "function": "Catalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results suggest that the GAD1 gene is a strong candidate gene that affects growth traits in cattle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.15", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0042802 identical protein binding;GO:0004351 glutamate decarboxylase activity;GO:0016831 carboxy-lyase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0048786 presynaptic active zone;GO:0098982 GABA-ergic synapse;GO:0005938 cell cortex;GO:0043679 axon terminus", "go_biological_process": "GO:0006538 L-glutamate catabolic process;GO:0009449 gamma-aminobutyric acid biosynthetic process;GO:0019752 carboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0VCA1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0II73-1", "uniprot_id": [ { "id": "CBPO_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0II73", "type": "external" } ], "mass": 43175.0, "length": 375, "protein_name": "Carboxypeptidase O", "gene_name": "CPO", "organism": "Bovine", "refseq_name": "carboxypeptidase O precursor", "refseq_ac": [ { "id": "NP_001068840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068840", "type": "external" } ], "gene_names_uniprotkb": "CPO", "gene_names_refseq": "CPO", "protein_names_uniprotkb": "Carboxypeptidase O; 3.4.17.-; CPO", "protein_names_refseq": "carboxypeptidase O precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:508767)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins. Can also cleave C-terminal hydrophobic amino acids, with a preference for small residues over large residues., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016324 apical plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0II73-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCI1-1", "uniprot_id": [ { "id": "OSGEP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCI1", "type": "external" } ], "mass": 36502.0, "length": 335, "protein_name": "tRNA N6-adenosine threonylcarbamoyltransferase", "gene_name": "OSGEP", "organism": "Bovine", "refseq_name": "tRNA N6-adenosine threonylcarbamoyltransferase", "refseq_ac": [ { "id": "NP_001068787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068787", "type": "external" } ], "gene_names_uniprotkb": "OSGEP", "gene_names_refseq": "OSGEP", "protein_names_uniprotkb": "tRNA N6-adenosine threonylcarbamoyltransferase; 2.3.1.234; N6-L-threonylcarbamoyladenine synthase; O-sialoglycoprotein endopeptidase; t(6)A synthase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP; tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP", "protein_names_refseq": "N6-L-threonylcarbamoyladenine synthase; probable O-sialoglycoprotein endopeptidase; probable tRNA N6-adenosine threonylcarbamoyltransferase; probable tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP; t(6)A synthase; t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP; tRNA N6-adenosine threonylcarbamoyltransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:507512)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity., [UniProtKB, HAMAP]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.234", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.234", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0061711 tRNA N(6)-L-threonylcarbamoyladenine synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000408 EKC/KEOPS complex", "go_biological_process": "GO:0002949 tRNA threonylcarbamoyladenosine modification;GO:0006400 tRNA modification;GO:0070525 tRNA threonylcarbamoyladenosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCI1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08D83-1", "uniprot_id": [ { "id": "RTN3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08D83", "type": "external" } ], "mass": 27455.0, "length": 256, "protein_name": "Reticulon-3", "gene_name": "RTN3", "organism": "Bovine", "refseq_name": "reticulon-3", "refseq_ac": [ { "id": "NP_872598", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_872598", "type": "external" } ], "gene_names_uniprotkb": "RTN3", "gene_names_refseq": "RTN3", "protein_names_uniprotkb": "Reticulon-3", "protein_names_refseq": "reticulon-3", "tax_id": 9913, "disease": "", "pathway": " (bta:359721)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12832288;16305752", "class_list": "", "function": "May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules. Acts also as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D9B5;Q6IM68", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0045202 synapse", "go_biological_process": "GO:0006915 apoptotic process;GO:0016192 vesicle-mediated transport;GO:1902430 negative regulation of amyloid-beta formation;GO:0071787 endoplasmic reticulum tubular network formation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q08D83-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DP3-1", "uniprot_id": [ { "id": "RELL1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DP3", "type": "external" } ], "mass": 29247.0, "length": 271, "protein_name": "RELT-like protein 1", "gene_name": "RELL1", "organism": "Bovine", "refseq_name": "RELT-like protein 1 precursor", "refseq_ac": [ { "id": "NP_001071566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071566", "type": "external" } ], "gene_names_uniprotkb": "RELL1", "gene_names_refseq": "RELL1", "protein_names_uniprotkb": "RELT-like protein 1", "protein_names_refseq": "RELT-like protein 1 precursor; RELT-like protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:768210)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1900745 positive regulation of p38MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DP3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0II50-1", "uniprot_id": [ { "id": "USB1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0II50", "type": "external" } ], "mass": 29957.0, "length": 265, "protein_name": "U6 snRNA phosphodiesterase 1", "gene_name": "USB1", "organism": "Bovine", "refseq_name": "U6 snRNA phosphodiesterase 1", "refseq_ac": [ { "id": "NP_001068945", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068945", "type": "external" } ], "gene_names_uniprotkb": "USB1", "gene_names_refseq": "C16orf57; C18H16orf57; USB1", "protein_names_uniprotkb": "U6 snRNA phosphodiesterase 1; 3'-5' RNA exonuclease USB1; 4.6.1.-", "protein_names_refseq": "3'-5' RNA exonuclease USB1; U6 snRNA biogenesis 1; U6 snRNA phosphodiesterase 1; UPF0406 protein C16orf57 homolog; putative U6 snRNA phosphodiesterase", "tax_id": 9913, "disease": "", "pathway": " (bta:510934)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "3'-5' RNA exonuclease that trims the 3' end of oligo(U) and oligo(A) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate. Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation. In addition also removes uridines from the 3' end of U6atac snRNA and possibly the vault RNA VTRNA1-1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "4.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0016829 lyase activity;GO:0000175 3'-5'-RNA exonuclease activity;GO:1990838 poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends;GO:0016787 hydrolase activity;GO:0004518 nuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0008380 RNA splicing;GO:0034477 U6 snRNA 3'-end processing;GO:0034472 snRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0II50-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DH3-1", "uniprot_id": [ { "id": "TRM9B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DH3", "type": "external" } ], "mass": 50498.0, "length": 453, "protein_name": "Probable tRNA methyltransferase 9B", "gene_name": "TRMT9B", "organism": "Bovine", "refseq_name": "probable tRNA methyltransferase 9B", "refseq_ac": [ { "id": "NP_001070300", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070300", "type": "external" } ], "gene_names_uniprotkb": "TRMT9B; KIAA1456; TRM9L", "gene_names_refseq": "C27H8ORF79; KIAA1456; TRM9L; TRMT9B", "protein_names_uniprotkb": "Probable tRNA methyltransferase 9B; 2.1.1.-; Probable tRNA methyltransferase 9-like protein", "protein_names_refseq": "probable tRNA methyltransferase 9-like protein; probable tRNA methyltransferase 9B", "tax_id": 9913, "disease": "", "pathway": " (bta:510845)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May modify wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0106335 tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity;GO:0008175 tRNA methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0002098 tRNA wobble uridine modification;GO:0030488 tRNA methylation;GO:0006400 tRNA modification;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DH3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08D86-1", "uniprot_id": [ { "id": "GLPK5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08D86", "type": "external" } ], "mass": 58765.0, "length": 528, "protein_name": "Glycerol kinase 5", "gene_name": "GK5", "organism": "Bovine", "refseq_name": "glycerol kinase 5", "refseq_ac": [ { "id": "NP_001030550", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030550", "type": "external" } ], "gene_names_uniprotkb": "GK5", "gene_names_refseq": "GK5", "protein_names_uniprotkb": "Glycerol kinase 5; 2.7.1.30; ATP:glycerol 3-phosphotransferase 5; GK 5; Glycerokinase 5", "protein_names_refseq": "ATP:glycerol 3-phosphotransferase 5; GK 5; glycerokinase 5; glycerol kinase 5 (putative); glycerol kinase 5; putative glycerol kinase 5", "tax_id": 9913, "disease": "", "pathway": " (bta:616031)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Skin-specific kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Involved in skin-specific regulation of sterol regulatory element-binding protein (SREBP) processing and lipid biosynthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58DK9", "ec_number_list": [ { "id": "2.7.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.30", "type": "external" } ], "go_molecular_function": "GO:0004370 glycerol kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0019563 glycerol catabolic process;GO:0046167 glycerol-3-phosphate biosynthetic process;GO:0006641 triglyceride metabolic process;GO:0006071 glycerol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08D86-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0II26-1", "uniprot_id": [ { "id": "AIMP2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0II26", "type": "external" } ], "mass": 35178.0, "length": 320, "protein_name": "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2", "gene_name": "AIMP2", "organism": "Bovine", "refseq_name": "aminoacyl tRNA synthase complex-interacting multifunctional protein 2", "refseq_ac": [ { "id": "NP_001069281", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069281", "type": "external" } ], "gene_names_uniprotkb": "AIMP2; JTV1", "gene_names_refseq": "AIMP2; JTV1", "protein_names_uniprotkb": "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Multisynthase complex auxiliary component p38; Protein JTV-1", "protein_names_refseq": "aminoacyl tRNA synthase complex-interacting multifunctional protein 2; multisynthase complex auxiliary component p38; multisynthetase complex auxiliary component p38; protein JTV-1", "tax_id": 9913, "disease": "", "pathway": " (bta:520979); (R-BTA-9856649)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0017101 aminoacyl-tRNA synthetase multienzyme complex", "go_biological_process": "GO:0030154 cell differentiation;GO:0006915 apoptotic process;GO:0006412 translation;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0II26-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCJ7-1", "uniprot_id": [ { "id": "RERG_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCJ7", "type": "external" } ], "mass": 22622.0, "length": 199, "protein_name": "Ras-related and estrogen-regulated growth inhibitor", "gene_name": "RERG", "organism": "Bovine", "refseq_name": "ras-related and estrogen-regulated growth inhibitor", "refseq_ac": [ { "id": "NP_001069666", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069666", "type": "external" } ], "gene_names_uniprotkb": "RERG", "gene_names_refseq": "RERG", "protein_names_uniprotkb": "Ras-related and estrogen-regulated growth inhibitor; 3.6.5.2", "protein_names_refseq": "ras-related and estrogen-regulated growth inhibitor", "tax_id": 9913, "disease": "", "pathway": " (bta:540025)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0007265 Ras protein signal transduction;GO:0030308 negative regulation of cell growth;GO:0009725 response to hormone;GO:0007163 establishment or maintenance of cell polarity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCJ7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02373-1", "uniprot_id": [ { "id": "NDUBA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q02373", "type": "external" } ], "mass": 20965.0, "length": 176, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10", "gene_name": "NDUFB10", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10", "refseq_ac": [ { "id": "NP_787012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787012", "type": "external" } ], "gene_names_uniprotkb": "NDUFB10", "gene_names_refseq": "NDUFB10; PDSW", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10; CI-PDSW; Complex I-PDSW; NADH-ubiquinone oxidoreductase PDSW subunit", "protein_names_refseq": "CI-PDSW; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10; NADH-ubiquinone oxidoreductase PDSW subunit; complex I-PDSW", "tax_id": 9913, "disease": "", "pathway": " (bta:327701); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10852722;1518044;18721790;28100784", "class_list": "", "function": "Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZC99", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q02373-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0II68-1", "uniprot_id": [ { "id": "ACMSD_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0II68", "type": "external" } ], "mass": 37923.0, "length": 336, "protein_name": "2-amino-3-carboxymuconate-6-semialdehyde decarboxylase", "gene_name": "ACMSD", "organism": "Bovine", "refseq_name": "2-amino-3-carboxymuconate-6-semialdehyde decarboxylase", "refseq_ac": [ { "id": "NP_001069162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069162", "type": "external" } ], "gene_names_uniprotkb": "ACMSD", "gene_names_refseq": "ACMSD", "protein_names_uniprotkb": "2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; 4.1.1.45; Picolinate carboxylase", "protein_names_refseq": "2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; picolinate carboxylase", "tax_id": 9913, "disease": "", "pathway": " (bta:515030)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolinate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.45", "type": "external" } ], "go_molecular_function": "GO:0001760 aminocarboxymuconate-semialdehyde decarboxylase activity;GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006569 L-tryptophan catabolic process;GO:1904985 negative regulation of quinolinate biosynthetic process;GO:0019748 secondary metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0II68-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIH8-1", "uniprot_id": [ { "id": "MINY3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIH8", "type": "external" } ], "mass": 49678.0, "length": 445, "protein_name": "Ubiquitin carboxyl-terminal hydrolase MINDY-3", "gene_name": "MINDY3", "organism": "Bovine", "refseq_name": "ubiquitin carboxyl-terminal hydrolase MINDY-3", "refseq_ac": [ { "id": "NP_001069575", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069575", "type": "external" } ], "gene_names_uniprotkb": "MINDY3; CARP; FAM188A", "gene_names_refseq": "C13H10ORF97; FAM188A; MINDY3", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase MINDY-3; 3.4.19.12; Deubiquitinating enzyme MINDY-3; Protein CARP", "protein_names_refseq": "deubiquitinating enzyme MINDY-3; family with sequence similarity 188 member A; protein FAM188A; ubiquitin carboxyl-terminal hydrolase FAM188A; ubiquitin carboxyl-terminal hydrolase MINDY-3", "tax_id": 9913, "disease": "", "pathway": " (bta:538509)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0006915 apoptotic process;GO:0071108 protein K48-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0IIH8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08E11-1", "uniprot_id": [ { "id": "PPIC_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08E11", "type": "external" } ], "mass": 22811.0, "length": 212, "protein_name": "Peptidyl-prolyl cis-trans isomerase C", "gene_name": "PPIC", "organism": "Bovine", "refseq_name": "peptidyl-prolyl cis-trans isomerase C precursor", "refseq_ac": [ { "id": "NP_001070378", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070378", "type": "external" } ], "gene_names_uniprotkb": "PPIC", "gene_names_refseq": "PPIC", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase C; 5.2.1.8; Cyclophilin C; PPIase C; Rotamase C", "protein_names_refseq": "PPIase C; cyclophilin C; peptidyl-prolyl cis-trans isomerase C precursor; peptidyl-prolyl cis-trans isomerase C; rotamase C", "tax_id": 9913, "disease": "", "pathway": " (bta:535494)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08E11-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCG0-1", "uniprot_id": [ { "id": "LYRM4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCG0", "type": "external" } ], "mass": 10711.0, "length": 91, "protein_name": "LYR motif-containing protein 4", "gene_name": "LYRM4", "organism": "Bovine", "refseq_name": "LYR motif-containing protein 4", "refseq_ac": [ { "id": "NP_001069774", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069774", "type": "external" } ], "gene_names_uniprotkb": "LYRM4; ISD11", "gene_names_refseq": "LYRM4", "protein_names_uniprotkb": "LYR motif-containing protein 4", "protein_names_refseq": "LYR motif-containing protein 4", "tax_id": 9913, "disease": "", "pathway": " (bta:614011); (R-BTA-1362409); (R-BTA-9854311); (R-BTA-9865881)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Stabilizing factor, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with NDUFAB1, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). May also participates in the iron-sulfur protein biogenesis in the cytoplasm through its interaction with the cytoplasmic form of NFS1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042803 protein homodimerization activity;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0016604 nuclear body;GO:1990221 L-cysteine desulfurase complex;GO:0099128 mitochondrial [2Fe-2S] assembly complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0044571 [2Fe-2S] cluster assembly;GO:0044572 [4Fe-4S] cluster assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCG0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08E39-1", "uniprot_id": [ { "id": "SPY2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08E39", "type": "external" } ], "mass": 34569.0, "length": 315, "protein_name": "Protein sprouty homolog 2", "gene_name": "SPRY2", "organism": "Bovine", "refseq_name": "protein sprouty homolog 2", "refseq_ac": [ { "id": "NP_001069615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069615", "type": "external" } ], "gene_names_uniprotkb": "SPRY2", "gene_names_refseq": "SPRY2", "protein_names_uniprotkb": "Protein sprouty homolog 2; Spry-2", "protein_names_refseq": "protein sprouty homolog 2; sprouty homolog 2; spry-2", "tax_id": 9913, "disease": "", "pathway": " (bta:539090); (R-BTA-1295596); (R-BTA-182971)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004860 protein kinase inhibitor activity;GO:0043539 protein serine/threonine kinase activator activity;GO:0030291 protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005874 microtubule;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0010628 positive regulation of gene expression;GO:0030335 positive regulation of cell migration;GO:0043066 negative regulation of apoptotic process;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08E39-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIJ2-1", "uniprot_id": [ { "id": "H10_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIJ2", "type": "external" } ], "mass": 20951.0, "length": 194, "protein_name": "Histone H1.0", "gene_name": "H1-0", "organism": "Bovine", "refseq_name": "histone H1.0", "refseq_ac": [ { "id": "NP_001069955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069955", "type": "external" } ], "gene_names_uniprotkb": "H1-0", "gene_names_refseq": "H1-0; H1F0", "protein_names_uniprotkb": "Histone H1.0; Histone H1(0)", "protein_names_refseq": "H1 histone family, member 0; histone H1(0); histone H1.0", "tax_id": 9913, "disease": "", "pathway": " (bta:617975)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin;GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0000786 nucleosome;GO:0017053 transcription repressor complex;GO:0016604 nuclear body", "go_biological_process": "GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0IIJ2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02380-1", "uniprot_id": [ { "id": "NDUB5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q02380", "type": "external" } ], "mass": 21589.0, "length": 189, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial", "gene_name": "NDUFB5", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial precursor", "refseq_ac": [ { "id": "NP_788829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788829", "type": "external" } ], "gene_names_uniprotkb": "NDUFB5", "gene_names_refseq": "NDUFB5", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial; CI-SGDH; Complex I-SGDH; NADH-ubiquinone oxidoreductase SGDH subunit", "protein_names_refseq": "CI-SGDH; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial precursor; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial; NADH-ubiquinone oxidoreductase SGDH subunit; complex I-SGDH", "tax_id": 9913, "disease": "", "pathway": " (bta:338061); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "10852722;1518044;18721790;28100784", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZV4;Q56K08", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q02380-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DB5-1", "uniprot_id": [ { "id": "STX5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DB5", "type": "external" } ], "mass": 39546.0, "length": 355, "protein_name": "Syntaxin-5", "gene_name": "STX5", "organism": "Bovine", "refseq_name": "syntaxin-5", "refseq_ac": [ { "id": "NP_001068912", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068912", "type": "external" } ], "gene_names_uniprotkb": "STX5", "gene_names_refseq": "STX5", "protein_names_uniprotkb": "Syntaxin-5", "protein_names_refseq": "syntaxin-5", "tax_id": 9913, "disease": "", "pathway": " (bta:510312); (R-BTA-204005); (R-BTA-5694530); (R-BTA-6807878); (R-BTA-6811438); (R-BTA-8980692); (R-BTA-9013106); (R-BTA-9013408); (R-BTA-9609523)", "pathway_count": 9, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0012505 endomembrane system;GO:0031982 vesicle;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0045732 positive regulation of protein catabolic process;GO:0006906 vesicle fusion;GO:0048278 vesicle docking", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DB5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05B60-1", "uniprot_id": [ { "id": "NUD14_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05B60", "type": "external" } ], "mass": 23901.0, "length": 222, "protein_name": "Uridine diphosphate glucose pyrophosphatase NUDT14", "gene_name": "NUDT14", "organism": "Bovine", "refseq_name": "uridine diphosphate glucose pyrophosphatase NUDT14", "refseq_ac": [ { "id": "NP_001099122", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099122", "type": "external" } ], "gene_names_uniprotkb": "NUDT14", "gene_names_refseq": "NUDT14; UGPP", "protein_names_uniprotkb": "Uridine diphosphate glucose pyrophosphatase NUDT14; 3.6.1.-; 3.6.1.13; Nucleoside diphosphate-linked moiety X motif 14; Nudix motif 14; UDPG pyrophosphatase; UGPPase", "protein_names_refseq": "UDPG pyrophosphatase; UGPPase; nucleoside diphosphate-linked moiety X motif 14; nudix (nucleoside diphosphate linked moiety X)-type motif 14; nudix motif 14; nudix-type motif 14; uridine diphosphate glucose pyrophosphatase NUDT14", "tax_id": 9913, "disease": "", "pathway": " (bta:100126049); (R-BTA-480985)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cytosolic pyrophosphatase hydrolyzing the diphosphate bond in various nucleotide-sugars with a higher efficiency for UDP-alpha-D-glucose and ADP-D-ribose., [UniProtKB, UniProtKB]; Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.58", "type": "external" }, { "id": "3.6.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.13", "type": "external" }, { "id": "2.7.7.96", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.96", "type": "external" }, { "id": "3.6.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.16", "type": "external" }, { "id": "3.6.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.53", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.45", "type": "external" } ], "go_molecular_function": "GO:0008768 UDP-sugar diphosphatase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0047631 ADP-ribose diphosphatase activity;GO:0080042 ADP-glucose pyrophosphohydrolase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0019693 ribose phosphate metabolic process;GO:0006753 nucleoside phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q05B60-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5F2-1", "uniprot_id": [ { "id": "PSMG1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5F2", "type": "external" } ], "mass": 33015.0, "length": 288, "protein_name": "Proteasome assembly chaperone 1", "gene_name": "PSMG1", "organism": "Bovine", "refseq_name": "proteasome assembly chaperone 1", "refseq_ac": [ { "id": "NP_001069815", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069815", "type": "external" } ], "gene_names_uniprotkb": "PSMG1", "gene_names_refseq": "PSMG1", "protein_names_uniprotkb": "Proteasome assembly chaperone 1", "protein_names_refseq": "proteasome assembly chaperone 1", "tax_id": 9913, "disease": "", "pathway": " (bta:614817); (R-BTA-9907900)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070628 proteasome binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0080129 proteasome core complex assembly;GO:0051131 chaperone-mediated protein complex assembly;GO:0043248 proteasome assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5F2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5J1-1", "uniprot_id": [ { "id": "FACR2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5J1", "type": "external" } ], "mass": 59077.0, "length": 515, "protein_name": "Fatty acyl-CoA reductase 2", "gene_name": "FAR2", "organism": "Bovine", "refseq_name": "fatty acyl-CoA reductase 2", "refseq_ac": [ { "id": "NP_001069490", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069490", "type": "external" } ], "gene_names_uniprotkb": "FAR2", "gene_names_refseq": "FAR2; MLSTD1", "protein_names_uniprotkb": "Fatty acyl-CoA reductase 2; 1.2.1.84; Far2", "protein_names_refseq": "fatty acyl-CoA reductase 2; male sterility domain containing 1; male sterility domain-containing protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:534380); (R-BTA-9640463)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the reduction of fatty acyl-CoA to fatty alcohols., [UniProtKB, UniProtKB]; Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols (FAls). A lower activity can be observed with shorter fatty acyl-CoA substrates. Can produce very long-chain and ultra long-chain FAls, regardless of whether they have a straight or branched chain. Involved in the production of ether lipids/plasmalogens and wax monoesters whose synthesis requires FAls as substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.2.1.84", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.84", "type": "external" } ], "go_molecular_function": "GO:0080019 alcohol-forming very long-chain fatty acyl-CoA reductase activity;GO:0102965 alcohol-forming long-chain fatty acyl-CoA reductase activity", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0035336 long-chain fatty-acyl-CoA metabolic process;GO:0010025 wax biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5J1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5A7-1", "uniprot_id": [ { "id": "4EBP1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5A7", "type": "external" } ], "mass": 12588.0, "length": 118, "protein_name": "Eukaryotic translation initiation factor 4E-binding protein 1", "gene_name": "EIF4EBP1", "organism": "Bovine", "refseq_name": "eukaryotic translation initiation factor 4E-binding protein 1", "refseq_ac": [ { "id": "NP_001071361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071361", "type": "external" } ], "gene_names_uniprotkb": "EIF4EBP1", "gene_names_refseq": "EIF4EBP1", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1", "protein_names_refseq": "4E-BP1; eIF4E-binding protein 1; eukaryotic translation initiation factor 4E-binding protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:509613); (R-BTA-166208); (R-BTA-72662)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008190 eukaryotic initiation factor 4E binding;GO:0030371 translation repressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0031929 TOR signaling;GO:0045947 negative regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5A7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81103-1", "uniprot_id": [ { "id": "VA0E1_BOVIN", "url": "https://www.uniprot.org/uniprot/P81103", "type": "external" } ], "mass": 9304.0, "length": 81, "protein_name": "V-type proton ATPase subunit e 1", "gene_name": "ATP6V0E1", "organism": "Bovine", "refseq_name": "V-type proton ATPase subunit e 1", "refseq_ac": [ { "id": "NP_001029222", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029222", "type": "external" } ], "gene_names_uniprotkb": "ATP6V0E1; ATP6H; ATP6V0E", "gene_names_refseq": "ATP6V0E1; ATP6V0E", "protein_names_uniprotkb": "V-type proton ATPase subunit e 1; V-ATPase 9.2 kDa membrane accessory protein; V-ATPase M9.2 subunit; V-ATPase subunit e 1; Vacuolar proton pump subunit e 1", "protein_names_refseq": "ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e; V-ATPase 9.2 kDa membrane accessory protein; V-ATPase M9.2 subunit; V-type proton ATPase subunit e 1; vacuolar proton pump subunit e 1", "tax_id": 9913, "disease": "", "pathway": " (bta:338075); (R-BTA-1222556); (R-BTA-77387); (R-BTA-917977); (R-BTA-9639288); (R-BTA-983712)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "9556572", "class_list": "", "function": "Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O18981;Q3ZBN2", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0033179 proton-transporting V-type ATPase, V0 domain", "go_biological_process": "GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P81103-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02370-1", "uniprot_id": [ { "id": "NDUA2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q02370", "type": "external" } ], "mass": 11080.0, "length": 99, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2", "gene_name": "NDUFA2", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2", "refseq_ac": [ { "id": "NP_787009", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787009", "type": "external" } ], "gene_names_uniprotkb": "NDUFA2", "gene_names_refseq": "B8; CI-B8; NDUFA2", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; CI-B8; Complex I-B8; NADH-ubiquinone oxidoreductase B8 subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; NADH-ubiquinone oxidoreductase B8 subunit; NADH-ubiquinone oxidoreductase complex; complex I-B8", "tax_id": 9913, "disease": "", "pathway": " (bta:327698); (R-BTA-611105); (R-BTA-6799198); (R-BTA-9837999)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "10852722;1518044;17760425;18721790;28100784", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Both the rate of the NADH-OH binding and its affinity to complex I are strongly decreased in the presence of succinate. The effect of succinate is completely reversed by rotenone, antimycin A, and uncoupler., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q148D8;Q2VYC4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q02370-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82915-1", "uniprot_id": [ { "id": "RT16_BOVIN", "url": "https://www.uniprot.org/uniprot/P82915", "type": "external" } ], "mass": 15132.0, "length": 135, "protein_name": "Small ribosomal subunit protein bS16m", "gene_name": "MRPS16", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein bS16m precursor", "refseq_ac": [ { "id": "NP_001068942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068942", "type": "external" } ], "gene_names_uniprotkb": "MRPS16; RPMS16", "gene_names_refseq": "MRP-S16; MRPS16; S16mt", "protein_names_uniprotkb": "Small ribosomal subunit protein bS16m; 28S ribosomal protein S16, mitochondrial; MRP-S16; S16mt", "protein_names_refseq": "28S ribosomal protein S16, mitochondrial; mitochondrial 28S ribosomal protein S16; small ribosomal subunit protein bS16m precursor; small ribosomal subunit protein bS16m", "tax_id": 9913, "disease": "", "pathway": " (bta:510899); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "11279123;24799711", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q17QA2", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P82915-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5D3-1", "uniprot_id": [ { "id": "CCND2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5D3", "type": "external" } ], "mass": 32613.0, "length": 289, "protein_name": "G1/S-specific cyclin-D2", "gene_name": "CCND2", "organism": "Bovine", "refseq_name": "G1/S-specific cyclin-D2", "refseq_ac": [ { "id": "NP_001069840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069840", "type": "external" } ], "gene_names_uniprotkb": "CCND2", "gene_names_refseq": "CCND2", "protein_names_uniprotkb": "G1/S-specific cyclin-D2", "protein_names_refseq": "G1/S-specific cyclin-D2", "tax_id": 9913, "disease": "", "pathway": " (bta:615414); (R-BTA-69231); (R-BTA-8934593); (R-BTA-9754119)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity;GO:0019901 protein kinase binding;GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031965 nuclear membrane;GO:0005815 microtubule organizing center;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0051301 cell division;GO:0000082 G1/S transition of mitotic cell cycle;GO:1900087 positive regulation of G1/S transition of mitotic cell cycle;GO:0008284 positive regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5D3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81623-1", "uniprot_id": [ { "id": "ERP29_BOVIN", "url": "https://www.uniprot.org/uniprot/P81623", "type": "external" } ], "mass": 28806.0, "length": 258, "protein_name": "Endoplasmic reticulum resident protein 29", "gene_name": "ERP29", "organism": "Bovine", "refseq_name": "endoplasmic reticulum resident protein 29 precursor", "refseq_ac": [ { "id": "NP_001069739", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069739", "type": "external" } ], "gene_names_uniprotkb": "ERP29", "gene_names_refseq": "ERP29", "protein_names_uniprotkb": "Endoplasmic reticulum resident protein 29; ERp29", "protein_names_refseq": "endoplasmic reticulum protein ERp29; endoplasmic reticulum resident protein 29 precursor; endoplasmic reticulum resident protein 29", "tax_id": 9913, "disease": "", "pathway": " (bta:613357)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9738895", "class_list": "", "function": "Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the ER (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q17QC3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0009986 cell surface;GO:0042470 melanosome", "go_biological_process": "GO:0050709 negative regulation of protein secretion;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0043410 positive regulation of MAPK cascade;GO:0009306 protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P81623-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5A3-1", "uniprot_id": [ { "id": "GSKIP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5A3", "type": "external" } ], "mass": 15714.0, "length": 139, "protein_name": "GSK3B-interacting protein", "gene_name": "GSKIP", "organism": "Bovine", "refseq_name": "GSK3B-interacting protein", "refseq_ac": [ { "id": "NP_001071524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071524", "type": "external" } ], "gene_names_uniprotkb": "GSKIP", "gene_names_refseq": "C21H14orf129; GSKIP", "protein_names_uniprotkb": "GSK3B-interacting protein; GSKIP", "protein_names_refseq": "GSK3-beta interaction protein; GSK3B-interacting protein", "tax_id": 9913, "disease": "", "pathway": " (bta:616052)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (By similarity). May play a role in cleft palate formation and is required for postnatal life through modulation of the activity of GSK3B during development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004860 protein kinase inhibitor activity;GO:0051018 protein kinase A binding;GO:0019207 kinase regulator activity;GO:0019901 protein kinase binding;GO:0034237 protein kinase A regulatory subunit binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006469 negative regulation of protein kinase activity;GO:0030111 regulation of Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress;GO:0060828 regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5A3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01321-1", "uniprot_id": [ { "id": "CXFA4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q01321", "type": "external" } ], "mass": 9325.0, "length": 82, "protein_name": "Cytochrome c oxidase subunit FA4", "gene_name": "COXFA4; NDUFA4", "organism": "Bovine", "refseq_name": "cytochrome c oxidase subunit FA4", "refseq_ac": [ { "id": "NP_787014", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787014", "type": "external" } ], "gene_names_uniprotkb": "COXFA4; NDUFA4; NDUFA4", "gene_names_refseq": "COXFA4; NDUFA4", "protein_names_uniprotkb": "Cytochrome c oxidase subunit FA4; CI-MLRQ; Complex I-MLRQ; Cytochrome c oxidase subunit NDUFA4; NADH-ubiquinone oxidoreductase MLRQ subunit", "protein_names_refseq": "CI-MLRQ; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4; NADH-ubiquinone oxidoreductase MLRQ subunit; complex I-MLRQ; cytochrome c oxidase subunit FA4; cytochrome c oxidase subunit NDUFA4", "tax_id": 9913, "disease": "", "pathway": " (bta:327704); (R-BTA-5628897); (R-BTA-611105); (R-BTA-9707564); (R-BTA-9864848)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "12837546;1518044;28100784", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules unsing 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (By similarity). COXFA4 is required for complex IV maintenance (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZC70", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q01321-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V8G2-1", "uniprot_id": [ { "id": "GABP2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V8G2", "type": "external" } ], "mass": 48475.0, "length": 447, "protein_name": "GA-binding protein subunit beta-2", "gene_name": "GABPB2", "organism": "Bovine", "refseq_name": "GA-binding protein subunit beta-2", "refseq_ac": [ { "id": "NP_001069710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069710", "type": "external" } ], "gene_names_uniprotkb": "GABPB2", "gene_names_refseq": "GABP2; GABPB2", "protein_names_uniprotkb": "GA-binding protein subunit beta-2; GABP subunit beta-2; GABPB-2", "protein_names_refseq": "GA binding protein transcription factor beta subunit 2; GA repeat binding protein, beta 2; GA-binding protein subunit beta-2; GABP subunit beta-2; GABPB-2", "tax_id": 9913, "disease": "", "pathway": " (bta:540818)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "May function as transcription factor capable of interacting with purine rich repeats (GA repeats)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0V8G2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIK4-1", "uniprot_id": [ { "id": "SPTSB_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIK4", "type": "external" } ], "mass": 9180.0, "length": 76, "protein_name": "Serine palmitoyltransferase small subunit B", "gene_name": "SPTSSB", "organism": "Bovine", "refseq_name": "serine palmitoyltransferase small subunit B", "refseq_ac": [ { "id": "NP_001104244", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104244", "type": "external" } ], "gene_names_uniprotkb": "SPTSSB; ADMP; SSSPTB", "gene_names_refseq": "C1H3orf57; C3orf57; SPTSSB", "protein_names_uniprotkb": "Serine palmitoyltransferase small subunit B; Protein ADMP; Small subunit of serine palmitoyltransferase B; ssSPTb", "protein_names_refseq": "ADMP; serine palmitoyltransferase small subunit B; small subunit of serine palmitoyltransferase B; ssSPTb", "tax_id": 9913, "disease": "", "pathway": " (bta:780785); (R-BTA-1660661)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. Within the SPT complex, SPTSSB stimulates the catalytic activity and plays a role in substrate specificity. SPT complexes with this subunit showing a preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004758 serine C-palmitoyltransferase activity", "go_cellular_component": "GO:0017059 serine palmitoyltransferase complex;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046513 ceramide biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0046512 sphingosine biosynthetic process;GO:0007029 endoplasmic reticulum organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0IIK4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DU9-1", "uniprot_id": [ { "id": "HP1B3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DU9", "type": "external" } ], "mass": 61477.0, "length": 555, "protein_name": "Heterochromatin protein 1-binding protein 3", "gene_name": "HP1BP3", "organism": "Bovine", "refseq_name": "heterochromatin protein 1-binding protein 3", "refseq_ac": [ { "id": "NP_001068904", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068904", "type": "external" } ], "gene_names_uniprotkb": "HP1BP3", "gene_names_refseq": "HP1BP3", "protein_names_uniprotkb": "Heterochromatin protein 1-binding protein 3", "protein_names_refseq": "heterochromatin protein 1-binding protein 3", "tax_id": 9913, "disease": "", "pathway": " (bta:510194)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity. May play a role in hypoxia-induced oncogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0031491 nucleosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005694 chromosome;GO:0000786 nucleosome", "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0006355 regulation of DNA-templated transcription;GO:0071456 cellular response to hypoxia;GO:0006334 nucleosome assembly;GO:0097298 regulation of nucleus size", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DU9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DL5-1", "uniprot_id": [ { "id": "COE2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DL5", "type": "external" } ], "mass": 62620.0, "length": 575, "protein_name": "Transcription factor COE2", "gene_name": "EBF2", "organism": "Bovine", "refseq_name": "transcription factor COE2", "refseq_ac": [ { "id": "NP_001071407", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071407", "type": "external" } ], "gene_names_uniprotkb": "EBF2; COE2", "gene_names_refseq": "EBF2", "protein_names_uniprotkb": "Transcription factor COE2; EBF-2; Early B-cell factor 2", "protein_names_refseq": "EBF-2; early B cell factor 2; transcription factor COE2", "tax_id": 9913, "disease": "", "pathway": " (bta:519342)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003682 chromatin binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0120162 positive regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DL5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79348-1", "uniprot_id": [ { "id": "RGS20_BOVIN", "url": "https://www.uniprot.org/uniprot/P79348", "type": "external" } ], "mass": 41917.0, "length": 374, "protein_name": "Regulator of G protein signaling 20", "gene_name": "RGS20", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RGS20", "gene_names_refseq": "", "protein_names_uniprotkb": "Regulator of G protein signaling 20; RGS20; Ret-RGS1; Retina-specific regulator of G protein signaling 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-418594); (R-BTA-418597)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "9096326;9353196;9748280", "class_list": "", "function": "Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G protein. Negatively regulates mu-opioid receptor-mediated activation of the G proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0045744 negative regulation of G protein-coupled receptor signaling pathway;GO:0009968 negative regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P79348-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79122-1", "uniprot_id": [ { "id": "PININ_BOVIN", "url": "https://www.uniprot.org/uniprot/P79122", "type": "external" } ], "mass": 79491.0, "length": 703, "protein_name": "Pinin", "gene_name": "PNN", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PNN", "gene_names_refseq": "", "protein_names_uniprotkb": "Pinin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8922384", "class_list": "", "function": "Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0016607 nuclear speck;GO:0071013 catalytic step 2 spliceosome;GO:0030057 desmosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P79122-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79266-1", "uniprot_id": [ { "id": "GASR_BOVIN", "url": "https://www.uniprot.org/uniprot/P79266", "type": "external" } ], "mass": 48781.0, "length": 454, "protein_name": "Gastrin/cholecystokinin type B receptor", "gene_name": "CCKBR", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CCKBR", "gene_names_refseq": "", "protein_names_uniprotkb": "Gastrin/cholecystokinin type B receptor; CCK-B receptor; CCK-BR; CCK2-R; Cholecystokinin-2 receptor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:281665)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8851180", "class_list": "", "function": "Receptor for the peptide hormones gastrin and cholecystokinin (CCK). Expressed throughout the central nervous system, where it modulates processes such as anxiety, analgesia, arousal and neuroleptic activity. Couples to both GNAI1 and GNAQ signaling pathways, but not to GNAS (By similarity). Upon gastrin activation, reduces glucose absorption in intestinal epithelial cells by downregulating SGLT1 and GLUT2 expression through suppression of the PI3K/Akt/eIF4B pathway (By similarity). In the kidney, decreases SGLT2 expression under high-glucose conditions via ERK/NF-kappa-B signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 3, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q2KI20", "ec_number_list": [], "go_molecular_function": "GO:0008188 neuropeptide receptor activity;GO:0015054 gastrin receptor activity;GO:0004951 cholecystokinin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007218 neuropeptide signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P79266-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80189-1", "uniprot_id": [ { "id": "LYSCN_BOVIN", "url": "https://www.uniprot.org/uniprot/P80189", "type": "external" } ], "mass": 16476.0, "length": 148, "protein_name": "Lysozyme C, non-stomach isozyme", "gene_name": "LYS", "organism": "Bovine", "refseq_name": "lysozyme C, non-stomach isozyme precursor", "refseq_ac": [ { "id": "NP_001071627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071627", "type": "external" } ], "gene_names_uniprotkb": "LYS; LZ", "gene_names_refseq": "LYS; LYZ; LZ", "protein_names_uniprotkb": "Lysozyme C, non-stomach isozyme; 1,4-beta-N-acetylmuramidase C; 3.2.1.17", "protein_names_refseq": "1,4-beta-N-acetylmuramidase C; lysozyme C, non-stomach isozyme precursor; lysozyme C, non-stomach isozyme", "tax_id": 9913, "disease": "", "pathway": " (bta:777776); (R-BTA-6798695); (R-BTA-6803157)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "7894180;8206386;8262986;8477739;8921904", "class_list": "glycogene;glycosylhydrolase", "function": "Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29447;Q2KIL2", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P80189-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80343-1", "uniprot_id": [ { "id": "MCPB_BOVIN", "url": "https://www.uniprot.org/uniprot/P80343", "type": "external" } ], "mass": 8363.0, "length": 74, "protein_name": "Monocyte chemotactic protein 1B", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Monocyte chemotactic protein 1B; MCP-1B", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7947749", "class_list": "", "function": "Chemotactic factor that attracts monocytes, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0008009 chemokine activity;GO:0048020 CCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0030335 positive regulation of cell migration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098 chemokine-mediated signaling pathway;GO:0048245 eosinophil chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P80343-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80416-1", "uniprot_id": [ { "id": "CYTA_BOVIN", "url": "https://www.uniprot.org/uniprot/P80416", "type": "external" } ], "mass": 11124.0, "length": 98, "protein_name": "Cystatin-A", "gene_name": "CSTA", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CSTA; STF1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cystatin-A; Cystatin-AS; Stefin-A", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7875311", "class_list": "", "function": "This is an intracellular thiol proteinase inhibitor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P80416-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81125-1", "uniprot_id": [ { "id": "SNAA_BOVIN", "url": "https://www.uniprot.org/uniprot/P81125", "type": "external" } ], "mass": 33225.0, "length": 295, "protein_name": "Alpha-soluble NSF attachment protein", "gene_name": "NAPA", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NAPA; SNAPA", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-soluble NSF attachment protein; N-ethylmaleimide-sensitive factor attachment protein alpha; SNAP-alpha", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "30573663;8455721", "class_list": "", "function": "Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (PubMed:8455721). Together with GNA12 promotes CDH5 localization to plasma membrane (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0005483 soluble NSF attachment protein activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043195 terminal bouton;GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex", "go_biological_process": "GO:0035494 SNARE complex disassembly;GO:0006886 intracellular protein transport;GO:0035249 synaptic transmission, glutamatergic;GO:0010807 regulation of synaptic vesicle priming", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P81125-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81126-1", "uniprot_id": [ { "id": "SNAB_BOVIN", "url": "https://www.uniprot.org/uniprot/P81126", "type": "external" } ], "mass": 33555.0, "length": 298, "protein_name": "Beta-soluble NSF attachment protein", "gene_name": "NAPB", "organism": "Bovine", "refseq_name": "beta-soluble NSF attachment protein", "refseq_ac": [ { "id": "NP_001039698", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039698", "type": "external" } ], "gene_names_uniprotkb": "NAPB; SNAPB", "gene_names_refseq": "NAPB", "protein_names_uniprotkb": "Beta-soluble NSF attachment protein; N-ethylmaleimide-sensitive factor attachment protein beta; SNAP-beta", "protein_names_refseq": "N-ethylmaleimide-sensitive factor attachment protein, beta; SNAP-beta; beta-soluble NSF attachment protein", "tax_id": 9913, "disease": "", "pathway": " (bta:517728); (R-BTA-204005); (R-BTA-6807878); (R-BTA-6811434); (R-BTA-6811438); (R-BTA-6811440)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "30573663;8455721", "class_list": "", "function": "Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, 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"mass": 13383.0, "length": 116, "protein_name": "Spermadhesin Z13", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Spermadhesin Z13", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "11012670", "class_list": "", "function": "May be involved in the fertilization process., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, 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"uniprot_canonical_ac": "P82708-1", "uniprot_id": [ { "id": "RET5_BOVIN", "url": "https://www.uniprot.org/uniprot/P82708", "type": "external" } ], "mass": 15962.0, "length": 135, "protein_name": "Retinol-binding protein 5", "gene_name": "RBP5", "organism": "Bovine", "refseq_name": "retinol-binding protein 5", "refseq_ac": [ { "id": "NP_001094662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094662", "type": "external" } ], "gene_names_uniprotkb": "RBP5", "gene_names_refseq": "CRBP-III; RBP5", "protein_names_uniprotkb": "Retinol-binding protein 5; CRBP-III; Cellular retinol-binding protein III", "protein_names_refseq": "cellular retinol-binding protein III; retinol binding protein 5, cellular; retinol-binding protein 5; retinol-binding protein III, cellular", "tax_id": 9913, "disease": "", "pathway": " (bta:539418)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11274389", "class_list": "", "function": "Intracellular transport of retinol., [UniProtKB, 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"glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7MBF0", "ec_number_list": [], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0019841 retinol binding;GO:0016918 retinal binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P82708-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82929-1", "uniprot_id": [ { "id": "RT34_BOVIN", "url": "https://www.uniprot.org/uniprot/P82929", "type": "external" } ], "mass": 25832.0, "length": 218, "protein_name": "Small ribosomal subunit protein mS34", "gene_name": "MRPS34", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein mS34", "refseq_ac": [ { "id": "NP_001030577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030577", "type": "external" } ], "gene_names_uniprotkb": "MRPS34", "gene_names_refseq": "MRPS34", "protein_names_uniprotkb": "Small ribosomal subunit protein mS34; 28S ribosomal protein S34, mitochondrial; MRP-S34; S34mt", "protein_names_refseq": "28S ribosomal protein S34, mitochondrial; MRP-S34; S34mt; small ribosomal subunit protein mS34", "tax_id": 9913, "disease": "", "pathway": " (bta:618357)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10751423;11279123", "class_list": "", "function": "Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0R5", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P82929-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P82943-1", "uniprot_id": [ { "id": "REG1_BOVIN", "url": "https://www.uniprot.org/uniprot/P82943", "type": "external" } ], "mass": 10281.0, "length": 92, "protein_name": "Regakine-1", "gene_name": "", "organism": "Bovine", "refseq_name": "regakine-1 precursor", "refseq_ac": [ { "id": "NP_001029392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029392", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "LOC504773", "protein_names_uniprotkb": "Regakine-1", "protein_names_refseq": "regakine-1 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:504773)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11290579;11570872", "class_list": "", "function": "Chemotactic activity for neutrophils and lymphocytes. Binds to heparin., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8MI76", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0008009 chemokine activity;GO:0048020 CCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0030335 positive regulation of cell migration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098 chemokine-mediated signaling pathway;GO:0048245 eosinophil chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P82943-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83095-1", "uniprot_id": [ { "id": "LACTB_BOVIN", "url": "https://www.uniprot.org/uniprot/P83095", "type": "external" } ], "mass": 61683.0, "length": 556, "protein_name": "Serine beta-lactamase-like protein LACTB, mitochondrial", "gene_name": "LACTB", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LACTB", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine beta-lactamase-like protein LACTB, mitochondrial; 3.4.-.-", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "11551941", "class_list": "", "function": "Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism. Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism. It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008233 peptidase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006508 proteolysis;GO:0006629 lipid metabolic process;GO:0019216 regulation of lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P83095-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83862-1", "uniprot_id": [ { "id": "OX26_BOVIN", "url": "https://www.uniprot.org/uniprot/P83862", "type": "external" } ], "mass": 14567.0, "length": 134, "protein_name": "Orexigenic neuropeptide QRFP", "gene_name": "QRFP", "organism": "Bovine", "refseq_name": "orexigenic neuropeptide QRFP precursor", "refseq_ac": [ { "id": "NP_937865", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_937865", "type": "external" } ], "gene_names_uniprotkb": "QRFP", "gene_names_refseq": "QRFP", "protein_names_uniprotkb": "Orexigenic neuropeptide QRFP; Neuropeptide RF-amide; Pyroglutamylated arginine-phenylalanine-amide peptide", "protein_names_refseq": "orexigenic neuropeptide QRFP precursor; orexigenic neuropeptide QRFP", "tax_id": 9913, "disease": "", "pathway": " (bta:379045)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12960173", "class_list": "", "function": "Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0031854 orexigenic neuropeptide QRFP receptor binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0007626 locomotory behavior;GO:0045777 positive regulation of blood pressure;GO:0060259 regulation of feeding behavior", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P83862-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P83939-1", "uniprot_id": [ { "id": "SCRN1_BOVIN", "url": "https://www.uniprot.org/uniprot/P83939", "type": "external" } ], "mass": 46202.0, "length": 414, "protein_name": "Secernin-1", "gene_name": "SCRN1", "organism": "Bovine", "refseq_name": "secernin-1", "refseq_ac": [ { "id": "NP_001104273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001104273", "type": "external" } ], "gene_names_uniprotkb": "SCRN1", "gene_names_refseq": "SCRN1", "protein_names_uniprotkb": "Secernin-1; p50", "protein_names_refseq": "p50; secernin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:534933)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12221138", "class_list": "", "function": "Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium., [UniProtKB, PubMed]; Secernin 1 increases both the extent of secretion and increases the sensitivity of mast cells to stimulation with calcium [secernin], [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016805 dipeptidase activity;GO:0070004 cysteine-type exopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P83939-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98091-1", "uniprot_id": [ { "id": "MUC19_BOVIN", "url": "https://www.uniprot.org/uniprot/P98091", "type": "external" } ], "mass": 462120.0, "length": 4596, "protein_name": "Mucin-19", "gene_name": "MUC19", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MUC19", "gene_names_refseq": "", "protein_names_uniprotkb": "Mucin-19; MUC-19; Submaxillary mucin-like protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "19393038;2204065", "class_list": "", "function": "May function in ocular mucus homeostasis., [UniProtKB, UniProtKB]", "predicted_glycosites": 19, "predicted_n_glycosites": 3, "predicted_o_glycosites": 16, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P98091-1", "record_type": "protein", "filter_code": "0000000.0000100.001000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98201-1", "uniprot_id": [ { "id": "NFAC1_BOVIN", "url": "https://www.uniprot.org/uniprot/P98201", "type": "external" } ], "mass": 85752.0, "length": 803, "protein_name": "Nuclear factor of activated T-cells, cytoplasmic 1", "gene_name": "NFATC1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NFATC1", "gene_names_refseq": "", "protein_names_uniprotkb": "Nuclear factor of activated T-cells, cytoplasmic 1; NF-ATc1; NF-ATc; NFAT transcription complex cytosolic component; NFATc1; NFATc", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8202141", "class_list": "", "function": "Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0033173 calcineurin-NFAT signaling cascade", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P98201-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01458-1", "uniprot_id": [ { "id": "DIAC_BOVIN", "url": "https://www.uniprot.org/uniprot/Q01458", "type": "external" } ], "mass": 19761.0, "length": 175, "protein_name": "Di-N-acetylchitobiase", "gene_name": "CTBS", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CTBS; CTB", "gene_names_refseq": "", "protein_names_uniprotkb": "Di-N-acetylchitobiase; 3.2.1.-", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "1527079", "class_list": "glycogene;glycosylhydrolase", "function": "Reducing-end exoglycosidase involved in glycan degradation. Hydrolyzes N,N'-diacetylchitobiose (GlnNAc2) (PubMed:1527079). Also hydrolyzes higher chitin-oligosaccharides (GlcNAc(n)) to monomeric GlcNAc acting on reducing-end residues (By similarity). During N-linked glycoprotein degradation, it cleaves single GlcNAc molecules uniquely from the reducing end of N,N'-diacetylchitobiose units linking oligosaccharides to proteins, and therefore it functions after cleavage of the Asn-GlcNAc bond and asparagine removal by glycosylasparaginase (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0004568 chitinase activity", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0006032 chitin catabolic process;GO:0009313 oligosaccharide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q01458-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01888-1", "uniprot_id": [ { "id": "GDC_BOVIN", "url": "https://www.uniprot.org/uniprot/Q01888", "type": "external" } ], "mass": 36085.0, "length": 330, "protein_name": "Mitochondrial coenzyme A transporter SLC25A16", "gene_name": "SLC25A16", "organism": "Bovine", "refseq_name": "mitochondrial coenzyme A transporter SLC25A16", "refseq_ac": [ { "id": "NP_777097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777097", "type": "external" } ], "gene_names_uniprotkb": "SLC25A16; GDA; GDC", "gene_names_refseq": "SLC25A16", "protein_names_uniprotkb": "Mitochondrial coenzyme A transporter SLC25A16; GDC; Graves disease carrier protein; Solute carrier family 25 member 16", "protein_names_refseq": "GDC; Graves disease autoantigen), member 16; graves disease carrier protein; human : Graves disease autoantigen; mitochondrial carrier; mitochondrial coenzyme A transporter SLC25A16; mitochondrial solute carrier protein homolog; solute carrier family 25 (mitochondrial carrier", "tax_id": 9913, "disease": "", "pathway": " (bta:282524)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1457817", "class_list": "", "function": "Mitochondrial inner membrane transporter that regulates coenzyme A homeostasis between cytosol and mitochondria. Could mediate the import of coenzyme A from the cytosol into the mitochondrial matrix. Alternatively, it could function in the export of 3'-dephospho-CoA from the mitochondrial matrix to the cytosol., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015228 coenzyme A transmembrane transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:1990559 mitochondrial coenzyme A transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q01888-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02369-1", "uniprot_id": [ { "id": "NDUB9_BOVIN", "url": "https://www.uniprot.org/uniprot/Q02369", "type": "external" } ], "mass": 21789.0, "length": 179, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9", "gene_name": "NDUFB9", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9", "refseq_ac": [ { "id": "NP_786977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786977", "type": "external" } ], "gene_names_uniprotkb": "NDUFB9; UQOR22", "gene_names_refseq": "B22; NDUFB9", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9; CI-B22; Complex I-B22; NADH-ubiquinone oxidoreductase B22 subunit", "protein_names_refseq": "CI-B22; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9; NADH-ubiquinone oxidoreductase B22 subunit; complex I-B22", "tax_id": 9913, "disease": "", "pathway": " (bta:327660); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10852722;1518044;18721790", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZU8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q02369-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02372-1", "uniprot_id": [ { "id": "NDUB8_BOVIN", "url": "https://www.uniprot.org/uniprot/Q02372", "type": "external" } ], "mass": 21652.0, "length": 186, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial", "gene_name": "NDUFB8", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial precursor", "refseq_ac": [ { "id": "NP_777092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777092", "type": "external" } ], "gene_names_uniprotkb": "NDUFB8", "gene_names_refseq": "NDUFB8", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; CI-ASHI; Complex I-ASHI; NADH-ubiquinone oxidoreductase ASHI subunit", "protein_names_refseq": "CI-ASHI; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa; NADH dehydrogenase 1 beta subcomplex 8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial precursor; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; NADH-ubiquinone oxidoreductase ASHI subunit; complex I-ASHI", "tax_id": 9913, "disease": "", "pathway": " (bta:282517); (R-BTA-1268020); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "10852722;1518044;18721790;28100784", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3SYR9;Q56K09", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q02372-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02374-1", "uniprot_id": [ { "id": "NDUB2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q02374", "type": "external" } ], "mass": 12282.0, "length": 108, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial", "gene_name": "NDUFB2", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_787022", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787022", "type": "external" } ], "gene_names_uniprotkb": "NDUFB2", "gene_names_refseq": "AGGG; NDUFB2", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial; CI-AGGG; Complex I-AGGG; NADH-ubiquinone oxidoreductase AGGG subunit", "protein_names_refseq": "CI-AGGG; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial precursor; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial; NADH-ubiquinone oxidoreductase AGGG subunit; complex I-AGGG", "tax_id": 9913, "disease": "", "pathway": " (bta:327713); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "10852722;1518044;18721790", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32L42", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q02374-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02377-1", "uniprot_id": [ { "id": "NDUA1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q02377", "type": "external" } ], "mass": 8105.0, "length": 70, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1", "gene_name": "NDUFA1", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1", "refseq_ac": [ { "id": "NP_786988", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786988", "type": "external" } ], "gene_names_uniprotkb": "NDUFA1", "gene_names_refseq": "CI-MWFE; MWFE; NDUFA1", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1; CI-MWFE; Complex I-MWFE; NADH-ubiquinone oxidoreductase MWFE subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1; NADH-ubiquinone oxidoreductase MWFE subunit; complex I-MWFE", "tax_id": 9913, "disease": "", "pathway": " (bta:327673); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "15056672;1518044;18721790", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB]; Subunit MWFE is required for assembly into complex I of seven hydrophobic subunits encoded in the mitochondrial genome, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZC06", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q02377-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02378-1", "uniprot_id": [ { "id": "NDUB1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q02378", "type": "external" } ], "mass": 6966.0, "length": 57, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1", "gene_name": "NDUFB1", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1", "refseq_ac": [ { "id": "NP_787003", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787003", "type": "external" } ], "gene_names_uniprotkb": "NDUFB1", "gene_names_refseq": "CI-MNLL; MNLL; NDUFB1", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1; CI-MNLL; Complex I-MNLL; NADH-ubiquinone oxidoreductase MNLL subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1; NADH-ubiquinone oxidoreductase MNLL subunit; complex I-MNLL", "tax_id": 9913, "disease": "", "pathway": " (bta:327690)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10852722;1518044;18721790", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q02378-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04645-1", "uniprot_id": [ { "id": "ATNG_BOVIN", "url": "https://www.uniprot.org/uniprot/Q04645", "type": "external" } ], "mass": 6545.0, "length": 58, "protein_name": "Sodium/potassium-transporting ATPase subunit gamma", "gene_name": "FXYD2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FXYD2; ATP1C; ATP1G1", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit gamma; FXYD domain-containing ion transport regulator 2; Na(+)/K(+) ATPase subunit gamma; Sodium pump gamma chain", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8387529", "class_list": "", "function": "May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017080 sodium channel regulator activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006813 potassium ion transport;GO:0006814 sodium ion transport;GO:1903278 positive regulation of sodium ion export across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q04645-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05716-1", "uniprot_id": [ { "id": "IBP4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05716", "type": "external" } ], "mass": 27890.0, "length": 258, "protein_name": "Insulin-like growth factor-binding protein 4", "gene_name": "IGFBP4", "organism": "Bovine", "refseq_name": "insulin-like growth factor-binding protein 4 precursor", "refseq_ac": [ { "id": "NP_776982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776982", "type": "external" } ], "gene_names_uniprotkb": "IGFBP4", "gene_names_refseq": "IGFBP4", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 4; IBP-4; IGF-binding protein 4; IGFBP-4", "protein_names_refseq": "IBP-4; IGF-binding protein 4; IGFBP-4; insulin-like growth factor-binding protein 4 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:282262); (R-BTA-381426); (R-BTA-8957275)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "1282670;16159699;26243597", "class_list": "", "function": "Follicular dominance was associated with low or decreased follicular fluid concentrations of IGFBP-4 and -5, [RefSeq, PubMed]; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors., [UniProtKB]; IGFBP4 maternal blood concentrations were lower during pregnancy than during non-pregnant cycles and synchronized control cycles. The lower IGFBP4 in maternal blood may result in an increase of free insulin-like growth factor- for local action., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A5D7U8", "ec_number_list": [], "go_molecular_function": "GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0043567 regulation of insulin-like growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q05716-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05717-1", "uniprot_id": [ { "id": "IBP5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05717", "type": "external" } ], "mass": 30314.0, "length": 271, "protein_name": "Insulin-like growth factor-binding protein 5", "gene_name": "IGFBP5", "organism": "Bovine", "refseq_name": "insulin-like growth factor-binding protein 5 precursor", "refseq_ac": [ { "id": "NP_001098797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098797", "type": "external" } ], "gene_names_uniprotkb": "IGFBP5", "gene_names_refseq": "IGFBP5", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 5; IBP-5; IGF-binding protein 5; IGFBP-5", "protein_names_refseq": "IBP-5; IGF-binding protein 5; IGFBP-5; insulin-like growth factor-binding protein 5 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:404185); (R-BTA-381426); (R-BTA-8957275)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "1282670;16159699;16698222;25491373;27800570", "class_list": "", "function": "Follicular dominance was associated with low or decreased follicular fluid concentrations of IGFBP-4 and -5, [RefSeq, PubMed]; GH reduces mRNA and protein expression of IGFBP-5 in bovine mammary epithelial cells, but it does not affect the expression of IGFBP-3, [RefSeq, PubMed]; IGFBP5, an important component of IGF signaling pathway, contributes greatly to bovine muscle cell development. A mechanism that miR-143 can regulate the proliferation and differentiation of bovine MSCs through changing expression of IGFBP5 was elucidated by our study., [RefSeq, PubMed]; Multifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Increases the cell proliferation of osteoblasts, intestinal smooth muscle cells and neuroblastoma cells (By similarity). Enhances adhesion and survival of epithelial cells but decreases adhesion of mesenchymal cells (By similarity). Once secreted, acts as a major mediator of mTORC1-dependent feedback inhibition of IGF1 signaling (By similarity). Also plays a role in the induction of extracellular matrix (ECM) production and deposition independently of its nuclear translocation and binding to IGFs. Acts itself as a growth factor that can act independently of IGFs to regulate bone formation. Acts as a ligand for the ROR1 receptor which triggers formation of ROR1/HER2 heterodimer to enhance CREB oncogenic signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; This study suggested that that higher level IGFBP-5 expression may have functional significance in lactation persistency., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QPM8", "ec_number_list": [], "go_molecular_function": "GO:0001968 fibronectin binding;GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0060416 response to growth hormone;GO:0043567 regulation of insulin-like growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q05717-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05718-1", "uniprot_id": [ { "id": "IBP6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05718", "type": "external" } ], "mass": 24967.0, "length": 237, "protein_name": "Insulin-like growth factor-binding protein 6", "gene_name": "IGFBP6", "organism": "Bovine", "refseq_name": "insulin-like growth factor-binding protein 6 precursor", "refseq_ac": [ { "id": "NP_001035585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035585", "type": "external" } ], "gene_names_uniprotkb": "IGFBP6", "gene_names_refseq": "IGFBP6", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 6; IBP-6; IGF-binding protein 6; IGFBP-6", "protein_names_refseq": "IBP-6; IGF-binding protein 6; IGFBP-6; insulin-like growth factor-binding protein 6 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:404186)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1282670;14966674", "class_list": "", "function": "IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2YDN5;Q865L3", "ec_number_list": [], "go_molecular_function": "GO:0001968 fibronectin binding;GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0016477 cell migration;GO:0043410 positive regulation of MAPK cascade;GO:0043567 regulation of insulin-like growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q05718-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05B45-1", "uniprot_id": [ { "id": "TACAN_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05B45", "type": "external" } ], "mass": 40730.0, "length": 343, "protein_name": "Transmembrane protein 120A", "gene_name": "TMEM120A", "organism": "Bovine", "refseq_name": "transmembrane protein 120A", "refseq_ac": [ { "id": "NP_001073068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073068", "type": "external" } ], "gene_names_uniprotkb": "TMEM120A", "gene_names_refseq": "TMEM120A", "protein_names_uniprotkb": "Transmembrane protein 120A; Ion channel TACAN", "protein_names_refseq": "ion channel TACAN; transmembrane protein 120A", "tax_id": 9913, "disease": "", "pathway": " (bta:520173)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Multifunctional protein involved in mechanosensation, and plays an essential role in lipid metabolism and adipocyte differentiation. May function as an ion channel involved in sensing mechanical stimuli. Mediates the mechanosensitivity of the PKD2-TMEM120A channel complex through direct physical interaction (By similarity). TMEM120A seems to affect mechanosensation by inhibiting PIEZO2 channels, possibly by altering cellular lipid content (By similarity). TMEM120A is structurally similar to a lipid-modifying enzyme, ELOVL7, and contains a bound coenzyme A molecule, which suggests it might function as an enzyme in lipid metabolism. Additionally, implicated in innate immune response against Zika virus. Acts as a key activator of the antiviral signaling involving STING1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0120225 coenzyme A binding;GO:0005216 monoatomic ion channel activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0051291 protein heterooligomerization;GO:0034220 monoatomic ion transmembrane transport;GO:0045444 fat cell differentiation;GO:0050966 detection of mechanical stimulus involved in sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q05B45-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05B50-1", "uniprot_id": [ { "id": "THG1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05B50", "type": "external" } ], "mass": 34740.0, "length": 298, "protein_name": "Probable tRNA(His) guanylyltransferase", "gene_name": "THG1L", "organism": "Bovine", "refseq_name": "probable tRNA(His) guanylyltransferase", "refseq_ac": [ { "id": "NP_001073702", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073702", "type": "external" } ], "gene_names_uniprotkb": "THG1L", "gene_names_refseq": "THG1L", "protein_names_uniprotkb": "Probable tRNA(His) guanylyltransferase; 2.7.7.79; tRNA-histidine guanylyltransferase", "protein_names_refseq": "probable tRNA(His) guanylyltransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:507084)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.79", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.79", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005525 GTP binding;GO:0008193 tRNA guanylyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:1990046 stress-induced mitochondrial fusion;GO:0006979 response to oxidative stress;GO:0008033 tRNA processing;GO:0006400 tRNA modification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q05B50-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05B51-1", "uniprot_id": [ { "id": "FDX2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05B51", "type": "external" } ], "mass": 19619.0, "length": 183, "protein_name": "Ferredoxin-2, mitochondrial", "gene_name": "FDX2", "organism": "Bovine", "refseq_name": "ferredoxin-2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001073695", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073695", "type": "external" } ], "gene_names_uniprotkb": "FDX2; FDX1L", "gene_names_refseq": "FDX1L; FDX2", "protein_names_uniprotkb": "Ferredoxin-2, mitochondrial; Adrenodoxin-like protein; Ferredoxin-1-like protein", "protein_names_refseq": "adrenodoxin-like protein, mitochondrial; ferredoxin 1 like; ferredoxin-1-like protein; ferredoxin-2, mitochondrial precursor; ferredoxin-2, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:505159); (R-BTA-1362409); (R-BTA-196108); (R-BTA-211976); (R-BTA-2395516)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Electron donor, of the core iron-sulfur cluster (ISC) assembly complex, that acts to reduce the persulfide into sulfide during [2Fe-2S] clusters assembly on the scaffolding protein ISCU (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). Essential for coenzyme Q biosynthesis: together with FDXR, transfers the electrons required for the hydroxylation reaction performed by COQ6 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process;GO:0022900 electron transport chain;GO:0044571 [2Fe-2S] cluster assembly;GO:0140647 P450-containing electron transport chain;GO:0044572 [4Fe-4S] cluster assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q05B51-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05B56-1", "uniprot_id": [ { "id": "TF2H3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05B56", "type": "external" } ], "mass": 34491.0, "length": 309, "protein_name": "General transcription factor IIH subunit 3", "gene_name": "GTF2H3", "organism": "Bovine", "refseq_name": "general transcription factor IIH subunit 3", "refseq_ac": [ { "id": "NP_001073057", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073057", "type": "external" } ], "gene_names_uniprotkb": "GTF2H3", "gene_names_refseq": "GTF2H3", "protein_names_uniprotkb": "General transcription factor IIH subunit 3; General transcription factor IIH polypeptide 3", "protein_names_refseq": "general transcription factor IIH polypeptide 3; general transcription factor IIH subunit 3; general transcription factor IIH, polypeptide 3, 34kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:511896); (R-BTA-113418); (R-BTA-5696395); (R-BTA-5696400); (R-BTA-674695); (R-BTA-6781823); (R-BTA-6782135); (R-BTA-6782210); (R-BTA-6796648); (R-BTA-72086); (R-BTA-73762); (R-BTA-73772); (R-BTA-73776); (R-BTA-73779); (R-BTA-73863); (R-BTA-75953); (R-BTA-75955); (R-BTA-76042); (R-BTA-77075)", "pathway_count": 19, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005675 transcription factor TFIIH holo complex;GO:0000438 core TFIIH complex portion of holo TFIIH complex;GO:0000439 transcription factor TFIIH core complex;GO:0097550 transcription preinitiation complex", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006289 nucleotide-excision repair;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q05B56-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05B58-1", "uniprot_id": [ { "id": "WASC3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05B58", "type": "external" } ], "mass": 21345.0, "length": 194, "protein_name": "WASH complex subunit 3", "gene_name": "WASHC3", "organism": "Bovine", "refseq_name": "WASH complex subunit 3", "refseq_ac": [ { "id": "NP_001073782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073782", "type": "external" } ], "gene_names_uniprotkb": "WASHC3; CCDC53", "gene_names_refseq": "CCDC53; WASHC3", "protein_names_uniprotkb": "WASH complex subunit 3; Coiled-coil domain-containing protein 53", "protein_names_refseq": "WASH complex subunit 3; WASH complex subunit CCDC53; coiled-coil domain containing 53; coiled-coil domain-containing protein 53", "tax_id": 9913, "disease": "", "pathway": " (bta:613720)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20498093", "class_list": "", "function": "Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005769 early endosome;GO:0071203 WASH complex", "go_biological_process": "GO:0015031 protein transport;GO:0030041 actin filament polymerization;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q05B58-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05B65-1", "uniprot_id": [ { "id": "SRFB1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05B65", "type": "external" } ], "mass": 48938.0, "length": 428, "protein_name": "Serum response factor-binding protein 1", "gene_name": "SRFBP1", "organism": "Bovine", "refseq_name": "serum response factor-binding protein 1", "refseq_ac": [ { "id": "NP_001098919", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098919", "type": "external" } ], "gene_names_uniprotkb": "SRFBP1", "gene_names_refseq": "SRFBP1", "protein_names_uniprotkb": "Serum response factor-binding protein 1; SRF-dependent transcription regulation-associated protein", "protein_names_refseq": "SRF-dependent transcription regulation-associated protein; serum response factor-binding protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:617136)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm;GO:0030686 90S preribosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q05B65-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05B71-1", "uniprot_id": [ { "id": "CISD2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05B71", "type": "external" } ], "mass": 15278.0, "length": 135, "protein_name": "CDGSH iron-sulfur domain-containing protein 2", "gene_name": "CISD2", "organism": "Bovine", "refseq_name": "CDGSH iron-sulfur domain-containing protein 2", "refseq_ac": [ { "id": "NP_001073807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073807", "type": "external" } ], "gene_names_uniprotkb": "CISD2; CDGSH2", "gene_names_refseq": "CISD2", "protein_names_uniprotkb": "CDGSH iron-sulfur domain-containing protein 2", "protein_names_refseq": "CDGSH iron-sulfur domain-containing protein 2; miner1; mitoNEET-related 1 protein", "tax_id": 9913, "disease": "", "pathway": " (bta:781260)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0000422 autophagy of mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q05B71-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06600-1", "uniprot_id": [ { "id": "TNFB_BOVIN", "url": "https://www.uniprot.org/uniprot/Q06600", "type": "external" } ], "mass": 22099.0, "length": 204, "protein_name": "Lymphotoxin-alpha", "gene_name": "LTA", "organism": "Bovine", "refseq_name": "lymphotoxin-alpha precursor", "refseq_ac": [ { "id": "NP_001013419", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013419", "type": "external" } ], "gene_names_uniprotkb": "LTA; TNFB; TNFSF1", "gene_names_refseq": "LTA", "protein_names_uniprotkb": "Lymphotoxin-alpha; LT-alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1", "protein_names_refseq": "LT-alpha; TNF superfamily, member 1; TNF-beta; lymphotoxin-alpha precursor; tumor necrosis factor ligand superfamily member 1", "tax_id": 9913, "disease": "", "pathway": " (bta:280845); (R-BTA-5668541); (R-BTA-5669034); (R-BTA-5676594)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "8260599", "class_list": "", "function": "Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (By similarity). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4FUB6", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:2001238 positive regulation of extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q06600-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DB0-1", "uniprot_id": [ { "id": "CEP44_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DB0", "type": "external" } ], "mass": 43580.0, "length": 385, "protein_name": "Centrosomal protein of 44 kDa", "gene_name": "CEP44", "organism": "Bovine", "refseq_name": "centrosomal protein of 44 kDa", "refseq_ac": [ { "id": "NP_001070301", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070301", "type": "external" } ], "gene_names_uniprotkb": "CEP44", "gene_names_refseq": "CEP44", "protein_names_uniprotkb": "Centrosomal protein of 44 kDa; Cep44", "protein_names_refseq": "centrosomal protein of 44 kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:510950)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall. Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005814 centriole;GO:0030496 midbody", "go_biological_process": "GO:0007098 centrosome cycle;GO:0010457 centriole-centriole cohesion;GO:0007099 centriole replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DB0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DB2-1", "uniprot_id": [ { "id": "STN1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DB2", "type": "external" } ], "mass": 41936.0, "length": 370, "protein_name": "CST complex subunit STN1", "gene_name": "STN1", "organism": "Bovine", "refseq_name": "CST complex subunit STN1", "refseq_ac": [ { "id": "NP_001070317", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070317", "type": "external" } ], "gene_names_uniprotkb": "STN1; OBFC1", "gene_names_refseq": "OBFC1; STN1", "protein_names_uniprotkb": "CST complex subunit STN1; Oligonucleotide/oligosaccharide-binding fold-containing protein 1; Suppressor of cdc thirteen homolog", "protein_names_refseq": "CST complex subunit STN1; STN1, CST complex subunit; oligonucleotide/oligosaccharide binding fold containing 1; oligonucleotide/oligosaccharide-binding fold-containing protein 1; suppressor of cdc thirteen homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:514213); (R-BTA-174411); (R-BTA-174430)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment and activation of DNA polymerase alpha. The CST complex facilitates recovery from many forms of exogenous DNA damage; seems to be involved in the re-initiation of DNA replication at repaired forks and/or dormant origins. Required for efficicient replication of the duplex region of the telomere. Promotes efficient replication of lagging-strand telomeres. Promotes general replication start following replication-fork stalling implicating new origin firing. May be in involved in C-strand fill-in during late S/G2 phase independent of its role in telomere duplex replication (By similarity)., [UniProtKB, UniProtKB]; Component of the CST complex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042162 telomeric DNA binding;GO:0043047 single-stranded telomeric DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000781 chromosome, telomeric region;GO:1990879 CST complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0010833 telomere maintenance via telomere lengthening;GO:0000723 telomere maintenance;GO:0016233 telomere capping;GO:0051052 regulation of DNA metabolic process;GO:0032211 negative regulation of telomere maintenance via telomerase", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DB2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DB4-1", "uniprot_id": [ { "id": "CPNE1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DB4", "type": "external" } ], "mass": 58923.0, "length": 537, "protein_name": "Copine-1", "gene_name": "CPNE1", "organism": "Bovine", "refseq_name": "copine-1", "refseq_ac": [ { "id": "NP_001070408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070408", "type": "external" } ], "gene_names_uniprotkb": "CPNE1", "gene_names_refseq": "CPNE1", "protein_names_uniprotkb": "Copine-1; Copine I", "protein_names_refseq": "copine I; copine-1", "tax_id": 9913, "disease": "", "pathway": " (bta:615677); (R-BTA-1483206); (R-BTA-6798695)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "11123945;19393038", "class_list": "", "function": "Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF receptor signaling pathway in a calcium-dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner. May recruit target proteins to the cell membrane in a calcium-dependent manner. May function in membrane trafficking. Involved in TNF-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit. Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0004175 endopeptidase activity;GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0071277 cellular response to calcium ion;GO:0043122 regulation of canonical NF-kappaB signal transduction;GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q08DB4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DD6-1", "uniprot_id": [ { "id": "IRF6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DD6", "type": "external" } ], "mass": 53105.0, "length": 467, "protein_name": "Interferon regulatory factor 6", "gene_name": "IRF6", "organism": "Bovine", "refseq_name": "interferon regulatory factor 6", "refseq_ac": [ { "id": "NP_001070402", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070402", "type": "external" } ], "gene_names_uniprotkb": "IRF6", "gene_names_refseq": "IRF6", "protein_names_uniprotkb": "Interferon regulatory factor 6; IRF-6", "protein_names_refseq": "IRF-6; interferon regulatory factor 6", "tax_id": 9913, "disease": "", "pathway": " (bta:614253)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable DNA-binding transcriptional activator. It is a key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045177 apical part of cell", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DD6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DD7-1", "uniprot_id": [ { "id": "SNX11_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DD7", "type": "external" } ], "mass": 30205.0, "length": 270, "protein_name": "Sorting nexin-11", "gene_name": "SNX11", "organism": "Bovine", "refseq_name": "sorting nexin-11", "refseq_ac": [ { "id": "NP_001070372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070372", "type": "external" } ], "gene_names_uniprotkb": "SNX11", "gene_names_refseq": "SNX11", "protein_names_uniprotkb": "Sorting nexin-11", "protein_names_refseq": "sorting nexin-11", "tax_id": 9913, "disease": "", "pathway": " (bta:534567)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Regulates the levels of TRPV3 by promoting its trafficking from the cell membrane to lysosome for degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1901981 phosphatidylinositol phosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016050 vesicle organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DD7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DE1-1", "uniprot_id": [ { "id": "CCG1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DE1", "type": "external" } ], "mass": 24694.0, "length": 223, "protein_name": "Voltage-dependent calcium channel gamma-1 subunit", "gene_name": "CACNG1", "organism": "Bovine", "refseq_name": "voltage-dependent calcium channel gamma-1 subunit", "refseq_ac": [ { "id": "NP_001073806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073806", "type": "external" } ], "gene_names_uniprotkb": "CACNG1", "gene_names_refseq": "CACNG1", "protein_names_uniprotkb": "Voltage-dependent calcium channel gamma-1 subunit; Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma", "protein_names_refseq": "calcium channel, voltage-dependent, gamma subunit 1; dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma; voltage-dependent calcium channel gamma-1 subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:781184)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005246 calcium channel regulator activity;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042383 sarcolemma;GO:0030315 T-tubule;GO:1990454 L-type voltage-gated calcium channel complex", "go_biological_process": "GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DE1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DG5-1", "uniprot_id": [ { "id": "HXB4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DG5", "type": "external" } ], "mass": 27683.0, "length": 251, "protein_name": "Homeobox protein Hox-B4", "gene_name": "HOXB4", "organism": "Bovine", "refseq_name": "homeobox protein Hox-B4", "refseq_ac": [ { "id": "NP_001071582", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071582", "type": "external" } ], "gene_names_uniprotkb": "HOXB4", "gene_names_refseq": "HOXB4", "protein_names_uniprotkb": "Homeobox protein Hox-B4", "protein_names_refseq": "homeobox protein Hox-B4", "tax_id": 9913, "disease": "", "pathway": " (bta:768240)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060218 hematopoietic stem cell differentiation;GO:0009952 anterior/posterior pattern specification;GO:0048704 embryonic skeletal system morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DG5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DH5-1", "uniprot_id": [ { "id": "R7BP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DH5", "type": "external" } ], "mass": 29044.0, "length": 257, "protein_name": "Regulator of G protein signaling 7-binding protein", "gene_name": "RGS7BP", "organism": "Bovine", "refseq_name": "regulator of G-protein signaling 7-binding protein", "refseq_ac": [ { "id": "NP_001070398", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070398", "type": "external" } ], "gene_names_uniprotkb": "RGS7BP; R7BP", "gene_names_refseq": "RGS7BP", "protein_names_uniprotkb": "Regulator of G protein signaling 7-binding protein; R7 family-binding protein", "protein_names_refseq": "R7 family-binding protein; regulator of G-protein signaling 7-binding protein", "tax_id": 9913, "disease": "", "pathway": " (bta:613327)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0098794 postsynapse;GO:0043005 neuron projection", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0009968 negative regulation of signal transduction;GO:0060078 regulation of postsynaptic membrane potential", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DH5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DH7-1", "uniprot_id": [ { "id": "AINX_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DH7", "type": "external" } ], "mass": 55396.0, "length": 499, "protein_name": "Alpha-internexin", "gene_name": "INA", "organism": "Bovine", "refseq_name": "alpha-internexin", "refseq_ac": [ { "id": "NP_001069426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069426", "type": "external" } ], "gene_names_uniprotkb": "INA", "gene_names_refseq": "INA", "protein_names_uniprotkb": "Alpha-internexin; Alpha-Inx", "protein_names_refseq": "alpha-Inx; alpha-internexin", "tax_id": 9913, "disease": "", "pathway": " (bta:532236)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NEFL to form the filamentous backbone to which NEFM and NEFH attach to form the cross-bridges (By similarity). May also cooperate with the neuronal intermediate filament protein PRPH to form filamentous networks (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0099184 structural constituent of postsynaptic intermediate filament cytoskeleton", "go_cellular_component": "GO:0005882 intermediate filament;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0005883 neurofilament;GO:0099160 postsynaptic intermediate filament cytoskeleton;GO:0098685 Schaffer collateral - CA1 synapse", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0045109 intermediate filament organization;GO:0099170 postsynaptic modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DH7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DI0-1", "uniprot_id": [ { "id": "NDF6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DI0", "type": "external" } ], "mass": 38673.0, "length": 337, "protein_name": "Neurogenic differentiation factor 6", "gene_name": "NEUROD6", "organism": "Bovine", "refseq_name": "neurogenic differentiation factor 6", "refseq_ac": [ { "id": "NP_001069689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069689", "type": "external" } ], "gene_names_uniprotkb": "NEUROD6", "gene_names_refseq": "NEUROD6", "protein_names_uniprotkb": "Neurogenic differentiation factor 6; NeuroD6", "protein_names_refseq": "neurogenic differentiation 6; neurogenic differentiation factor 6", "tax_id": 9913, "disease": "", "pathway": " (bta:540464)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0061564 axon development;GO:0007423 sensory organ development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DI0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DK0-1", "uniprot_id": [ { "id": "TM129_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DK0", "type": "external" } ], "mass": 40454.0, "length": 362, "protein_name": "E3 ubiquitin-protein ligase TM129", "gene_name": "TMEM129", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase TM129", "refseq_ac": [ { "id": "NP_001070332", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070332", "type": "external" } ], "gene_names_uniprotkb": "TMEM129", "gene_names_refseq": "TMEM129", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TM129; 2.3.2.27; RING-type E3 ubiquitin transferase TM129", "protein_names_refseq": "E3 ubiquitin-protein ligase TM129; RING-type E3 ubiquitin transferase TM129; transmembrane protein 129, E3 ubiquitin protein ligase", "tax_id": 9913, "disease": "", "pathway": " (bta:518991)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006986 response to unfolded protein", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DK0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DK1-1", "uniprot_id": [ { "id": "IGS11_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DK1", "type": "external" } ], "mass": 46530.0, "length": 437, "protein_name": "Immunoglobulin superfamily member 11", "gene_name": "IGSF11", "organism": "Bovine", "refseq_name": "immunoglobulin superfamily member 11 precursor", "refseq_ac": [ { "id": "NP_001070389", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070389", "type": "external" } ], "gene_names_uniprotkb": "IGSF11", "gene_names_refseq": "IGSF11", "protein_names_uniprotkb": "Immunoglobulin superfamily member 11; IgSF11", "protein_names_refseq": "immunoglobulin superfamily member 11 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:540003)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DK1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DK4-1", "uniprot_id": [ { "id": "GHC1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DK4", "type": "external" } ], "mass": 34531.0, "length": 322, "protein_name": "Mitochondrial glutamate carrier 1", "gene_name": "SLC25A22", "organism": "Bovine", "refseq_name": "mitochondrial glutamate carrier 1", "refseq_ac": [ { "id": "NP_001068627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068627", "type": "external" } ], "gene_names_uniprotkb": "SLC25A22; GC1", "gene_names_refseq": "SLC25A22", "protein_names_uniprotkb": "Mitochondrial glutamate carrier 1; GC-1; Glutamate/H(+) symporter 1; Solute carrier family 25 member 22", "protein_names_refseq": "GC-1; glutamate/H(+) symporter 1; mitochondrial glutamate carrier 1; solute carrier family 25 (mitochondrial carrier, glutamate), member 22", "tax_id": 9913, "disease": "", "pathway": " (bta:504371); (R-BTA-442660); (R-BTA-9856872)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial glutamate/H(+) symporter. Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (By similarity). Plays a role in the control of glucose-stimulated insulin secretion (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005280 amino acid:proton symporter activity;GO:0005313 L-glutamate transmembrane transporter activity;GO:0015183 L-aspartate transmembrane transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0050796 regulation of insulin secretion;GO:0015810 aspartate transmembrane transport;GO:0015813 L-glutamate transmembrane transport;GO:0043490 malate-aspartate shuttle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DK4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DM2-1", "uniprot_id": [ { "id": "DPH2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DM2", "type": "external" } ], "mass": 51795.0, "length": 489, "protein_name": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2", "gene_name": "DPH2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DPH2", "gene_names_refseq": "", "protein_names_uniprotkb": "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Diphthamide biosynthesis protein 2; Diphtheria toxin resistance protein 2; S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:768224)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (By similarity). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D957", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0090560 2-(3-amino-3-carboxypropyl)histidine synthase activity", "go_cellular_component": "GO:0120513 2-(3-amino-3-carboxypropyl)histidine synthase complex", "go_biological_process": "GO:0017183 protein histidyl modification to diphthamide", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08DM2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DN6-1", "uniprot_id": [ { "id": "BORG1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DN6", "type": "external" } ], "mass": 22496.0, "length": 210, "protein_name": "Cdc42 effector protein 2", "gene_name": "CDC42EP2", "organism": "Bovine", "refseq_name": "cdc42 effector protein 2", "refseq_ac": [ { "id": "NP_001068809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068809", "type": "external" } ], "gene_names_uniprotkb": "CDC42EP2; BORG1; CEP2", "gene_names_refseq": "CDC42EP2", "protein_names_uniprotkb": "Cdc42 effector protein 2; Binder of Rho GTPases 1", "protein_names_refseq": "CDC42 effector protein (Rho GTPase binding) 2; binder of Rho GTPases 1; cdc42 effector protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:507966); (R-BTA-9013406)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0031267 small GTPase binding;GO:0001515 opioid peptide activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0007266 Rho protein signal transduction;GO:0008360 regulation of cell shape;GO:0031274 positive regulation of pseudopodium assembly;GO:0030838 positive regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DN6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DN8-1", "uniprot_id": [ { "id": "FLOT1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DN8", "type": "external" } ], "mass": 47353.0, "length": 427, "protein_name": "Flotillin-1", "gene_name": "FLOT1", "organism": "Bovine", "refseq_name": "flotillin-1", "refseq_ac": [ { "id": "NP_001070355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070355", "type": "external" } ], "gene_names_uniprotkb": "FLOT1", "gene_names_refseq": "FLOT1", "protein_names_uniprotkb": "Flotillin-1", "protein_names_refseq": "flotillin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:532573); (R-BTA-5213460); (R-BTA-5675482); (R-BTA-8849932); (R-BTA-8980692); (R-BTA-9013106)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0022617 extracellular matrix disassembly;GO:0035556 intracellular signal transduction;GO:0072659 protein localization to plasma membrane;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0032226 positive regulation of synaptic transmission, dopaminergic", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DN8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DP6-1", "uniprot_id": [ { "id": "RHG10_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DP6", "type": "external" } ], "mass": 89405.0, "length": 785, "protein_name": "Rho GTPase-activating protein 10", "gene_name": "ARHGAP10", "organism": "Bovine", "refseq_name": "rho GTPase-activating protein 10", "refseq_ac": [ { "id": "NP_001070298", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070298", "type": "external" } ], "gene_names_uniprotkb": "ARHGAP10", "gene_names_refseq": "ARHGAP10", "protein_names_uniprotkb": "Rho GTPase-activating protein 10; Rho-type GTPase-activating protein 10", "protein_names_refseq": "rho GTPase-activating protein 10; rho-type GTPase-activating protein 10", "tax_id": 9913, "disease": "", "pathway": " (bta:510704); (R-BTA-8980692); (R-BTA-9013148)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes. Also converts Cdc42 to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death. Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0010008 endosome membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0043066 negative regulation of apoptotic process;GO:0007010 cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DP6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DQ2-1", "uniprot_id": [ { "id": "GFPT2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DQ2", "type": "external" } ], "mass": 77081.0, "length": 682, "protein_name": "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2", "gene_name": "GFPT2", "organism": "Bovine", "refseq_name": "glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2", "refseq_ac": [ { "id": "NP_001070351", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070351", "type": "external" } ], "gene_names_uniprotkb": "GFPT2", "gene_names_refseq": "GFPT2", "protein_names_uniprotkb": "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2; 2.6.1.16; D-fructose-6-phosphate amidotransferase 2; GFAT 2; GFAT2; Glutamine:fructose-6-phosphate amidotransferase 2; Hexosephosphate aminotransferase 2", "protein_names_refseq": "D-fructose-6-phosphate amidotransferase 2; GFAT 2; GFAT2; glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2; glutamine:fructose-6-phosphate amidotransferase 2; hexosephosphate aminotransferase 2", "tax_id": 9913, "disease": "", "pathway": " (bta:530101); (R-BTA-446210)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.6.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.16", "type": "external" } ], "go_molecular_function": "GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity;GO:0097367 carbohydrate derivative binding", "go_cellular_component": "", "go_biological_process": "GO:0006487 protein N-linked glycosylation;GO:0006048 UDP-N-acetylglucosamine biosynthetic process;GO:0006047 UDP-N-acetylglucosamine metabolic process;GO:0006002 fructose 6-phosphate metabolic process;GO:1901137 carbohydrate derivative biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DQ2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DS0-1", "uniprot_id": [ { "id": "KLH21_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DS0", "type": "external" } ], "mass": 66563.0, "length": 597, "protein_name": "Kelch-like protein 21", "gene_name": "KLHL21", "organism": "Bovine", "refseq_name": "kelch-like protein 21", "refseq_ac": [ { "id": "NP_001070279", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070279", "type": "external" } ], "gene_names_uniprotkb": "KLHL21", "gene_names_refseq": "KLHL21", "protein_names_uniprotkb": "Kelch-like protein 21", "protein_names_refseq": "kelch-like 21; kelch-like protein 21", "tax_id": 9913, "disease": "", "pathway": " (bta:506632)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005827 polar microtubule;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0035853 chromosome passenger complex localization to spindle midzone;GO:0051301 cell division;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DS0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DV9-1", "uniprot_id": [ { "id": "T131L_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DV9", "type": "external" } ], "mass": 174577.0, "length": 1598, "protein_name": "Transmembrane protein 131-like", "gene_name": "TMEM131L", "organism": "Bovine", "refseq_name": "transmembrane protein 131-like precursor", "refseq_ac": [ { "id": "NP_001070271", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070271", "type": "external" } ], "gene_names_uniprotkb": "TMEM131L", "gene_names_refseq": "KIAA0922; TMEM131L", "protein_names_uniprotkb": "Transmembrane protein 131-like", "protein_names_refseq": "transmembrane protein 131-like precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:505156)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DV9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DX6-1", "uniprot_id": [ { "id": "GDF10_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DX6", "type": "external" } ], "mass": 52626.0, "length": 478, "protein_name": "Growth/differentiation factor 10", "gene_name": "GDF10", "organism": "Bovine", "refseq_name": "growth/differentiation factor 10 precursor", "refseq_ac": [ { "id": "NP_001069635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069635", "type": "external" } ], "gene_names_uniprotkb": "GDF10; BMP3B", "gene_names_refseq": "GDF10", "protein_names_uniprotkb": "Growth/differentiation factor 10; BMP-3B; Bone morphogenetic protein 3B; GDF-10", "protein_names_refseq": "BMP-3b; GDF-10; bone morphogenetic protein 3b; growth/differentiation factor 10 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:539510)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21805344", "class_list": "", "function": "GDF10 gene might have potential effects on body measurement traits in the above mentioned cattle populations and could be used for marker-assisted selection., [RefSeq, PubMed]; Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0045444 fat cell differentiation;GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway;GO:0045669 positive regulation of osteoblast differentiation;GO:0001649 osteoblast differentiation;GO:0030279 negative regulation of ossification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08DX6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DY6-1", "uniprot_id": [ { "id": "E2F6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DY6", "type": "external" } ], "mass": 32246.0, "length": 285, "protein_name": "Transcription factor E2F6", "gene_name": "E2F6", "organism": "Bovine", "refseq_name": "transcription factor E2F6", "refseq_ac": [ { "id": "NP_001070316", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070316", "type": "external" } ], "gene_names_uniprotkb": "E2F6", "gene_names_refseq": "E2F6", "protein_names_uniprotkb": "Transcription factor E2F6; E2F-6", "protein_names_refseq": "E2F-6; transcription factor E2F6", "tax_id": 9913, "disease": "", "pathway": " (bta:514085); (R-BTA-8953750)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains (By similarity). Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression (By similarity). Represses expression of some meiosis-specific genes, including SLC25A31/ANT4 (By similarity). May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0071339 MLL1 complex;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DY6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DZ5-1", "uniprot_id": [ { "id": "SDC1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DZ5", "type": "external" } ], "mass": 32316.0, "length": 311, "protein_name": "Syndecan-1", "gene_name": "SDC1", "organism": "Bovine", "refseq_name": "syndecan-1 precursor", "refseq_ac": [ { "id": "NP_001069392", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069392", "type": "external" } ], "gene_names_uniprotkb": "SDC1", "gene_names_refseq": "SDC1", "protein_names_uniprotkb": "Syndecan-1; SYND1", "protein_names_refseq": "SYND1; syndecan-1 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:529759); (R-BTA-1971475); (R-BTA-2022928); (R-BTA-2024096); (R-BTA-3000170); (R-BTA-449836); (R-BTA-975634); (R-BTA-9769735); (R-BTA-9769739)", "pathway_count": 9, "publication_count": 2, "publication_id_list": "24480876;28864018", "class_list": "", "function": "Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (By similarity). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Changing placental expression indicates possible involvement in fetomaternal communication and placental maturation, [RefSeq, PubMed]; Heparan sulfate is involved in both centralized and decentralized glycocalyx-mediated mechanotransduction, with GPC1 acting as a centralized agent and SDC1 functioning in decentralized mechanotransmission. GPC1 mediates NOS3 activation., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 1, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q08DZ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08E07-1", "uniprot_id": [ { "id": "CELF3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08E07", "type": "external" } ], "mass": 50092.0, "length": 461, "protein_name": "CUGBP Elav-like family member 3", "gene_name": "CELF3", "organism": "Bovine", "refseq_name": "CUGBP Elav-like family member 3", "refseq_ac": [ { "id": "NP_001070313", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070313", "type": "external" } ], "gene_names_uniprotkb": "CELF3; TNRC4", "gene_names_refseq": "CELF3; TNRC4", "protein_names_uniprotkb": "CUGBP Elav-like family member 3; Bruno-like protein 1; CELF-3; CUG-BP- and ETR-3-like factor 3; ELAV-type RNA-binding protein 1; ETR-1; RNA-binding protein BRUNOL-1; Trinucleotide repeat-containing gene 4 protein", "protein_names_refseq": "CELF-3; CUG-BP- and ETR-3-like factor 3; CUGBP Elav-like family member 3; ELAV-type RNA-binding protein 1; ETR-1; RNA-binding protein BRUNOL-1; bruno-like protein 1; trinucleotide repeat containing 4; trinucleotide repeat-containing gene 4 protein", "tax_id": 9913, "disease": "", "pathway": " (bta:513347)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0006376 mRNA splice site recognition;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08E07-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08E20-1", "uniprot_id": [ { "id": "ESTD_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08E20", "type": "external" } ], "mass": 31548.0, "length": 282, "protein_name": "S-formylglutathione hydrolase", "gene_name": "ESD", "organism": "Bovine", "refseq_name": "S-formylglutathione hydrolase", "refseq_ac": [ { "id": "NP_001069533", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069533", "type": "external" } ], "gene_names_uniprotkb": "ESD", "gene_names_refseq": "ESD", "protein_names_uniprotkb": "S-formylglutathione hydrolase; 3.1.2.12; Esterase D; FGH", "protein_names_refseq": "FGH; S-formylglutathione hydrolase; esterase D/formylglutathione hydrolase", "tax_id": 9913, "disease": "", "pathway": " (bta:535653); (R-BTA-156590)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine hydrolase involved in the detoxification of formaldehyde., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.2.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.12", "type": "external" } ], "go_molecular_function": "GO:0052689 carboxylic ester hydrolase activity;GO:0018738 S-formylglutathione hydrolase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle;GO:0005737 cytoplasm", "go_biological_process": "GO:0046294 formaldehyde catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08E20-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08E66-1", "uniprot_id": [ { "id": "WFKN2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08E66", "type": "external" } ], "mass": 62994.0, "length": 574, "protein_name": "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2", "gene_name": "WFIKKN2", "organism": "Bovine", "refseq_name": "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 precursor", "refseq_ac": [ { "id": "NP_001070353", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070353", "type": "external" } ], "gene_names_uniprotkb": "WFIKKN2", "gene_names_refseq": "WFIKKN2", "protein_names_uniprotkb": "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2", "protein_names_refseq": "WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 precursor; WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:531979)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0048019 receptor antagonist activity;GO:0050431 transforming growth factor beta binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08E66-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0II44-1", "uniprot_id": [ { "id": "S2541_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0II44", "type": "external" } ], "mass": 38571.0, "length": 349, "protein_name": "Mitochondrial carrier protein SCaMC-3L", "gene_name": "SLC25A41", "organism": "Bovine", "refseq_name": "mitochondrial carrier protein SCaMC-3L", "refseq_ac": [ { "id": "NP_001069309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069309", "type": "external" } ], "gene_names_uniprotkb": "SLC25A41", "gene_names_refseq": "SCaMC-3L; SLC25A41", "protein_names_uniprotkb": "Mitochondrial carrier protein SCaMC-3L; Mitochondrial ATP-Mg/Pi carrier protein SLC25A41; SCaMC-3-like; SCaMC-3L; Small calcium-binding mitochondrial carrier protein 3-like; Solute carrier family 25 member 41", "protein_names_refseq": "SCaMC-3-like; mitochondrial ATP-Mg/Pi carrier protein SLC25A41; mitochondrial carrier protein SCaMC-3L; small calcium-binding mitochondrial carrier protein 3-like", "tax_id": 9913, "disease": "", "pathway": " (bta:523430)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Calcium-independent ATP-Mg/Pi exchanger that catalyzes the electroneutral exchange of Mg-ATP or free ADP against an hydrogenphosphate and participates in the net transport of adenine nucleotides across the mitochondria inner membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005347 ATP transmembrane transporter activity;GO:0015217 ADP transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "GO:0015866 ADP transport;GO:0015867 ATP transport;GO:0140021 mitochondrial ADP transmembrane transport;GO:1990544 mitochondrial ATP transmembrane transport;GO:0055085 transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0II44-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0II64-1", "uniprot_id": [ { "id": "SUN3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0II64", "type": "external" } ], "mass": 40619.0, "length": 360, "protein_name": "SUN domain-containing protein 3", "gene_name": "SUN3", "organism": "Bovine", "refseq_name": "SUN domain-containing protein 3", "refseq_ac": [ { "id": "NP_001069552", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069552", "type": "external" } ], "gene_names_uniprotkb": "SUN3; SUNC1", "gene_names_refseq": "SUN3; SUNC1", "protein_names_uniprotkb": "SUN domain-containing protein 3; Sad1/unc-84 domain-containing protein 1", "protein_names_refseq": "SUN domain-containing protein 3; Sad1 and UNC84 domain containing 1; sad1/unc-84 domain-containing protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:537130)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nuclear remodeling during sperm head formation in spermatogenesis. A probable SUN3:SYNE1 LINC complex may tether spermatid nuclei to posterior cytoskeletal structures such as the manchette., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005637 nuclear inner membrane;GO:0034993 meiotic nuclear membrane microtubule tethering complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0II64-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0II78-1", "uniprot_id": [ { "id": "CCRL2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0II78", "type": "external" } ], "mass": 40061.0, "length": 348, "protein_name": "Chemokine C-C motif receptor-like 2", "gene_name": "CCRL2", "organism": "Bovine", "refseq_name": "chemokine C-C motif receptor-like 2", "refseq_ac": [ { "id": "NP_001069200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069200", "type": "external" } ], "gene_names_uniprotkb": "CCRL2", "gene_names_refseq": "CCRL2", "protein_names_uniprotkb": "Chemokine C-C motif receptor-like 2", "protein_names_refseq": "chemokine C-C motif receptor-like 2-like; chemokine C-C motif receptor-like 2", "tax_id": 9913, "disease": "", "pathway": " (bta:515976); (R-BTA-380108)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptor. Plays a critical role for the development of Th2 responses (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding;GO:0048020 CCR chemokine receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0060326 cell chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0II78-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0II87-1", "uniprot_id": [ { "id": "TFAM_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0II87", "type": "external" } ], "mass": 28907.0, "length": 246, "protein_name": "Transcription factor A, mitochondrial", "gene_name": "TFAM", "organism": "Bovine", "refseq_name": "transcription factor A, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001029188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029188", "type": "external" } ], "gene_names_uniprotkb": "TFAM", "gene_names_refseq": "TFAM", "protein_names_uniprotkb": "Transcription factor A, mitochondrial; mtTFA", "protein_names_refseq": "mitochondrial transcription factor 1; mtTFA; transcription factor 6-like 2; transcription factor A, mitochondrial precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:510059)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16005429;16285882", "class_list": "", "function": "Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA., [UniProtKB, UniProtKB]; De novo mtTFA expression associated with mitochondrial biogenesis activation & high levels of nuclear respiratory factor-1 mRNA from oocyte stage onwards argue for essential function of these factors during the first steps of bovine embryogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Our results suggest that TFAM plays an important role in lipid metabolism and may be a strong candidate gene for obesity in mammals., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001018 mitochondrial promoter sequence-specific DNA binding;GO:0003682 chromatin binding;GO:0034246 mitochondrial transcription factor activity", "go_cellular_component": "GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0006391 transcription initiation at mitochondrial promoter;GO:0006390 mitochondrial transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0II87-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0II91-1", "uniprot_id": [ { "id": "DJC21_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0II91", "type": "external" } ], "mass": 61717.0, "length": 533, "protein_name": "DnaJ homolog subfamily C member 21", "gene_name": "DNAJC21", "organism": "Bovine", "refseq_name": "dnaJ homolog subfamily C member 21", "refseq_ac": [ { "id": "NP_001179147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179147", "type": "external" } ], "gene_names_uniprotkb": "DNAJC21", "gene_names_refseq": "DNAJC21", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 21", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 21; dnaJ homolog subfamily C member 21", "tax_id": 9913, "disease": "", "pathway": " (bta:509302)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0II91-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IID9-1", "uniprot_id": [ { "id": "GLPK_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IID9", "type": "external" } ], "mass": 61261.0, "length": 559, "protein_name": "Glycerol kinase", "gene_name": "GK", "organism": "Bovine", "refseq_name": "glycerol kinase", "refseq_ac": [ { "id": "NP_001068704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068704", "type": "external" } ], "gene_names_uniprotkb": "GK", "gene_names_refseq": "GK", "protein_names_uniprotkb": "Glycerol kinase; 2.7.1.30; ATP:glycerol 3-phosphotransferase; Glycerokinase", "protein_names_refseq": "ATP:glycerol 3-phosphotransferase; glycerokinase; glycerol kinase", "tax_id": 9913, "disease": "", "pathway": " (bta:505987); (R-BTA-75109)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Kinase that plays a key role in glycerol metabolism, catalyzing its phosphorylation to produce sn-glycerol 3-phosphate. Sn-glycerol 3-phosphate is a crucial intermediate in various metabolic pathways, such as the synthesis of glycerolipids and triglycerides, glycogenesis, glycolysis and gluconeogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.30", "type": "external" } ], "go_molecular_function": "GO:0004370 glycerol kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:0019563 glycerol catabolic process;GO:0046167 glycerol-3-phosphate biosynthetic process;GO:0006641 triglyceride metabolic process;GO:0006071 glycerol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0IID9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIE0-1", "uniprot_id": [ { "id": "CPLX3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIE0", "type": "external" } ], "mass": 17625.0, "length": 158, "protein_name": "Complexin-3", "gene_name": "CPLX3", "organism": "Bovine", "refseq_name": "complexin-3", "refseq_ac": [ { "id": "NP_001071357", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071357", "type": "external" } ], "gene_names_uniprotkb": "CPLX3", "gene_names_refseq": "CPLX3", "protein_names_uniprotkb": "Complexin-3", "protein_names_refseq": "complexin-3", "tax_id": 9913, "disease": "", "pathway": " (bta:509248)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005326 neurotransmitter transmembrane transporter activity;GO:0019905 syntaxin binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0005829 cytosol;GO:0043195 terminal bouton;GO:0030672 synaptic vesicle membrane;GO:0031201 SNARE complex", "go_biological_process": "GO:0007601 visual perception;GO:0050804 modulation of chemical synaptic transmission;GO:0030073 insulin secretion;GO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane;GO:0016079 synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0IIE0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIE8-1", "uniprot_id": [ { "id": "DJB14_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIE8", "type": "external" } ], "mass": 42488.0, "length": 379, "protein_name": "DnaJ homolog subfamily B member 14", "gene_name": "DNAJB14", "organism": "Bovine", "refseq_name": "dnaJ homolog subfamily B member 14", "refseq_ac": [ { "id": "NP_001069599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069599", "type": "external" } ], "gene_names_uniprotkb": "DNAJB14", "gene_names_refseq": "DNAJB14", "protein_names_uniprotkb": "DnaJ homolog subfamily B member 14", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily B, member 14; dnaJ homolog subfamily B member 14", "tax_id": 9913, "disease": "", "pathway": " (bta:538849)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway. Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70. When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006457 protein folding;GO:0071218 cellular response to misfolded protein;GO:0065003 protein-containing complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0IIE8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0III6-1", "uniprot_id": [ { "id": "DNJB6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0III6", "type": "external" } ], "mass": 26944.0, "length": 242, "protein_name": "DnaJ homolog subfamily B member 6", "gene_name": "DNAJB6", "organism": "Bovine", "refseq_name": "dnaJ homolog subfamily B member 6", "refseq_ac": [ { "id": "NP_776957", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776957", "type": "external" } ], "gene_names_uniprotkb": "DNAJB6; MRJ", "gene_names_refseq": "DNAJB6", "protein_names_uniprotkb": "DnaJ homolog subfamily B member 6; MRJ", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily B, member 6; MRJ; dnaJ homolog subfamily B member 6", "tax_id": 9913, "disease": "", "pathway": " (bta:282215)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11896048", "class_list": "", "function": "Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70 (By similarity). Plays an indispensable role in the organization of KRT8/KRT18 filaments (By similarity). Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin (PubMed:11896048). Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (By similarity). Also reduces cellular toxicity and caspase-3 activity (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8WN90", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0030544 Hsp70 protein binding;GO:0044183 protein folding chaperone;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0030018 Z disc;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006457 protein folding;GO:0090084 negative regulation of inclusion body assembly;GO:0050877 nervous system process;GO:0032880 regulation of protein localization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0III6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIL7-1", "uniprot_id": [ { "id": "CPLX1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIL7", "type": "external" } ], "mass": 15000.0, "length": 134, "protein_name": "Complexin-1", "gene_name": "CPLX1", "organism": "Bovine", "refseq_name": "complexin-1", "refseq_ac": [ { "id": "NP_001071571", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071571", "type": "external" } ], "gene_names_uniprotkb": "CPLX1", "gene_names_refseq": "CPLX1", "protein_names_uniprotkb": "Complexin-1", "protein_names_refseq": "complexin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:768228); (R-BTA-181429); (R-BTA-181430); (R-BTA-210500); (R-BTA-212676); (R-BTA-264642); (R-BTA-888590)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0005829 cytosol;GO:0043195 terminal bouton;GO:0043204 perikaryon;GO:0031201 SNARE complex", "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission;GO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane;GO:0016079 synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0IIL7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P563-1", "uniprot_id": [ { "id": "FUCM_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P563", "type": "external" } ], "mass": 16469.0, "length": 153, "protein_name": "Fucose mutarotase", "gene_name": "FUOM", "organism": "Bovine", "refseq_name": "fucose mutarotase", "refseq_ac": [ { "id": "NP_001069746", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069746", "type": "external" } ], "gene_names_uniprotkb": "FUOM", "gene_names_refseq": "C26H10orf125; FUOM", "protein_names_uniprotkb": "Fucose mutarotase; 5.1.3.29", "protein_names_refseq": "fucose mutarotase; protein fucU homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:613571)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.1.3.29", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.29", "type": "external" } ], "go_molecular_function": "GO:0042806 fucose binding;GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives;GO:0036373 L-fucose mutarotase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006004 fucose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P563-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P564-1", "uniprot_id": [ { "id": "CRBN_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P564", "type": "external" } ], "mass": 50800.0, "length": 444, "protein_name": "Protein cereblon", "gene_name": "CRBN", "organism": "Bovine", "refseq_name": "protein cereblon", "refseq_ac": [ { "id": "NP_001068995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068995", "type": "external" } ], "gene_names_uniprotkb": "CRBN", "gene_names_refseq": "CRBN", "protein_names_uniprotkb": "Protein cereblon", "protein_names_refseq": "protein cereblon", "tax_id": 9913, "disease": "", "pathway": " (bta:511585)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2, ILF2 or GLUL. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons. Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1 (By similarity). May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism (By similarity). Plays a negative role in TLR4 signaling by interacting with TRAF6 and ECSIT, leading to inhibition of ECSIT ubiquitination, an important step of the signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0060173 limb development;GO:0035641 locomotory exploration behavior;GO:0030177 positive regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P564-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P583-1", "uniprot_id": [ { "id": "KCNV1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P583", "type": "external" } ], "mass": 56725.0, "length": 503, "protein_name": "Potassium voltage-gated channel subfamily V member 1", "gene_name": "KCNV1", "organism": "Bovine", "refseq_name": "potassium voltage-gated channel subfamily V member 1", "refseq_ac": [ { "id": "NP_001160032", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160032", "type": "external" } ], "gene_names_uniprotkb": "KCNV1", "gene_names_refseq": "KCNV1", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily V member 1; Voltage-gated potassium channel subunit Kv8.1", "protein_names_refseq": "potassium channel, subfamily V, member 1; potassium voltage-gated channel subfamily V member 1; voltage-gated potassium channel subunit Kv8.1", "tax_id": 9913, "disease": "", "pathway": " (bta:505732)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P583-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P591-1", "uniprot_id": [ { "id": "MA6D1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P591", "type": "external" } ], "mass": 20611.0, "length": 192, "protein_name": "MAP6 domain-containing protein 1", "gene_name": "MAP6D1", "organism": "Bovine", "refseq_name": "MAP6 domain-containing protein 1", "refseq_ac": [ { "id": "NP_001069822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069822", "type": "external" } ], "gene_names_uniprotkb": "MAP6D1", "gene_names_refseq": "MAP6D1", "protein_names_uniprotkb": "MAP6 domain-containing protein 1", "protein_names_refseq": "MAP6 domain-containing protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:614904)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May have microtubule-stabilizing activity., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005798 Golgi-associated vesicle;GO:0005874 microtubule;GO:0005801 cis-Golgi network", "go_biological_process": "GO:0000226 microtubule cytoskeleton organization;GO:0030705 cytoskeleton-dependent intracellular transport;GO:0070507 regulation of microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P591-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P593-1", "uniprot_id": [ { "id": "DAW1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P593", "type": "external" } ], "mass": 45857.0, "length": 415, "protein_name": "Dynein assembly factor with WD repeat domains 1", "gene_name": "DAW1", "organism": "Bovine", "refseq_name": "dynein assembly factor with WD repeat domains 1", "refseq_ac": [ { "id": "NP_001069398", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069398", "type": "external" } ], "gene_names_uniprotkb": "DAW1; WDR69", "gene_names_refseq": "DAW1; WDR69", "protein_names_uniprotkb": "Dynein assembly factor with WD repeat domains 1; Outer row dynein assembly protein 16 homolog; WD repeat-containing protein 69", "protein_names_refseq": "WD repeat domain 69; WD repeat-containing protein 69; dynein assembly factor with WD repeat domains 1; dynein assembly factor with WDR repeat domains 1; outer row dynein assembly protein 16 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:530118)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for axonemal dynein assembly and ciliary motility in ciliated organs, including Kupffer's vesicle, during embryogenesis. Facilitates the onset of robust cilia motility during development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005929 cilium;GO:0019005 SCF ubiquitin ligase complex;GO:0036064 ciliary basal body", "go_biological_process": "GO:0007507 heart development;GO:0007368 determination of left/right symmetry;GO:0000209 protein polyubiquitination;GO:0042073 intraciliary transport;GO:0036158 outer dynein arm assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P593-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5A1-1", "uniprot_id": [ { "id": "DCTN3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5A1", "type": "external" } ], "mass": 21192.0, "length": 186, "protein_name": "Dynactin subunit 3", "gene_name": "DCTN3", "organism": "Bovine", "refseq_name": "dynactin subunit 3", "refseq_ac": [ { "id": "NP_001069128", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069128", "type": "external" } ], "gene_names_uniprotkb": "DCTN3", "gene_names_refseq": "DCTN3", "protein_names_uniprotkb": "Dynactin subunit 3", "protein_names_refseq": "dynactin 3 (p22); dynactin subunit 3", "tax_id": 9913, "disease": "", "pathway": " (bta:514327); (R-BTA-2132295); (R-BTA-2565942); (R-BTA-3371497); (R-BTA-380259); (R-BTA-380270); (R-BTA-380284); (R-BTA-380320); (R-BTA-5620912); (R-BTA-6807878); (R-BTA-6811436); (R-BTA-8854518)", "pathway_count": 12, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). Together with dynein may be involved in spindle assembly and cytokinesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0032154 cleavage furrow;GO:0005869 dynactin complex", "go_biological_process": "GO:0061640 cytoskeleton-dependent cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5A1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5A2-1", "uniprot_id": [ { "id": "COQ5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5A2", "type": "external" } ], "mass": 37591.0, "length": 330, "protein_name": "2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial", "gene_name": "COQ5", "organism": "Bovine", "refseq_name": "2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial", "refseq_ac": [ { "id": "XP_010812368", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010812368", "type": "external" } ], "gene_names_uniprotkb": "COQ5", "gene_names_refseq": "COQ5", "protein_names_uniprotkb": "2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; 2.1.1.201; Ubiquinone biosynthesis methyltransferase COQ5", "protein_names_refseq": "2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:533208); (R-BTA-2142789)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "28100784", "class_list": "", "function": "Methyltransferase required for the conversion of 2-decaprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.201", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.201", "type": "external" }, { "id": "2.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.-.-", "type": "external" }, { "id": "1.14.15.45", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.45", "type": "external" }, { "id": "1.14.15.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.15.46", "type": "external" } ], "go_molecular_function": "GO:0008425 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity", "go_cellular_component": "GO:0031314 extrinsic component of mitochondrial inner membrane", "go_biological_process": "GO:0006744 ubiquinone biosynthetic process;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q0P5A2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5A4-1", "uniprot_id": [ { "id": "UCK1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5A4", "type": "external" } ], "mass": 31195.0, "length": 277, "protein_name": "Uridine-cytidine kinase 1", "gene_name": "UCK1", "organism": "Bovine", "refseq_name": "uridine-cytidine kinase 1", "refseq_ac": [ { "id": "NP_001069260", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069260", "type": "external" } ], "gene_names_uniprotkb": "UCK1", "gene_names_refseq": "UCK1", "protein_names_uniprotkb": "Uridine-cytidine kinase 1; 2.7.1.48; Cytidine monophosphokinase 1; UCK 1; Uridine monophosphokinase 1", "protein_names_refseq": "UCK 1; cytidine monophosphokinase 1; uridine monophosphokinase 1; uridine-cytidine kinase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:519697); (R-BTA-73614)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.48", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004849 uridine kinase activity;GO:0043771 cytidine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0044206 UMP salvage;GO:0044211 CTP salvage", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5A4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5B2-1", "uniprot_id": [ { "id": "METL2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5B2", "type": "external" } ], "mass": 43485.0, "length": 378, "protein_name": "tRNA N(3)-cytidine methyltransferase METTL2", "gene_name": "METTL2", "organism": "Bovine", "refseq_name": "tRNA N(3)-cytidine methyltransferase METTL2", "refseq_ac": [ { "id": "NP_001068714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068714", "type": "external" } ], "gene_names_uniprotkb": "METTL2", "gene_names_refseq": "METTL2A; METTL2B; METTL2", "protein_names_uniprotkb": "tRNA N(3)-cytidine methyltransferase METTL2; 2.1.1.-; Methyltransferase-like protein 2", "protein_names_refseq": "methyltransferase 2A, methylcytidine; methyltransferase like 2A; methyltransferase like 2B; methyltransferase-like protein 2; tRNA N(3)-cytidine methyltransferase METTL2; tRNA N(3)-methylcytidine methyltransferase METTL2", "tax_id": 9913, "disease": "", "pathway": " (bta:506221)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). N(3)-methylcytidine methylation by METTL2 requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0016427 tRNA (cytidine) methyltransferase activity;GO:0052735 tRNA (cytidine-3-)-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0030488 tRNA methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5B2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5B7-1", "uniprot_id": [ { "id": "AAAD_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5B7", "type": "external" } ], "mass": 45604.0, "length": 399, "protein_name": "Arylacetamide deacetylase", "gene_name": "AADAC", "organism": "Bovine", "refseq_name": "arylacetamide deacetylase", "refseq_ac": [ { "id": "NP_001069259", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069259", "type": "external" } ], "gene_names_uniprotkb": "AADAC", "gene_names_refseq": "AADAC", "protein_names_uniprotkb": "Arylacetamide deacetylase; 3.1.1.3", "protein_names_refseq": "arylacetamide deacetylase", "tax_id": 9913, "disease": "", "pathway": " (bta:519557)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" } ], "go_molecular_function": "GO:0017171 serine hydrolase activity;GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0010898 positive regulation of triglyceride catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5B7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5C0-1", "uniprot_id": [ { "id": "LMF1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5C0", "type": "external" } ], "mass": 64022.0, "length": 561, "protein_name": "Lipase maturation factor 1", "gene_name": "LMF1", "organism": "Bovine", "refseq_name": "lipase maturation factor 1", "refseq_ac": [ { "id": "NP_001068658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068658", "type": "external" } ], "gene_names_uniprotkb": "LMF1; TMEM112", "gene_names_refseq": "LMF1; TMEM112", "protein_names_uniprotkb": "Lipase maturation factor 1; Transmembrane protein 112", "protein_names_refseq": "lipase maturation factor 1; transmembrane protein 112", "tax_id": 9913, "disease": "", "pathway": " (bta:505124)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway. Each LMF1 molecule chaperones 50 or more molecules of LPL (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006641 triglyceride metabolic process;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5C0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5C3-1", "uniprot_id": [ { "id": "MSX2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5C3", "type": "external" } ], "mass": 29027.0, "length": 267, "protein_name": "Homeobox protein MSX-2", "gene_name": "MSX2", "organism": "Bovine", "refseq_name": "homeobox protein MSX-2", "refseq_ac": [ { "id": "NP_001073082", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073082", "type": "external" } ], "gene_names_uniprotkb": "MSX2", "gene_names_refseq": "MSX2", "protein_names_uniprotkb": "Homeobox protein MSX-2", "protein_names_refseq": "homeobox protein MSX-2", "tax_id": 9913, "disease": "", "pathway": " (bta:540230)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0009887 animal organ morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5C3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5D8-1", "uniprot_id": [ { "id": "NSUN3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5D8", "type": "external" } ], "mass": 38384.0, "length": 338, "protein_name": "tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial", "gene_name": "NSUN3", "organism": "Bovine", "refseq_name": "tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial", "refseq_ac": [ { "id": "NP_001069469", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069469", "type": "external" } ], "gene_names_uniprotkb": "NSUN3", "gene_names_refseq": "NSUN3", "protein_names_uniprotkb": "tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial; 2.1.1.-; NOL1/NOP2/Sun domain family member 3", "protein_names_refseq": "NOL1/NOP2/Sun domain family, member 3; NOP2/Sun RNA methyltransferase family member 3; putative methyltransferase NSUN3; tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:533791)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt-tRNA(Met). mt-tRNA(Met) methylation at cytosine(34) takes place at the wobble position of the anticodon and initiates the formation of 5-formylcytosine (f(5)c) at this position. mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0016428 tRNA (cytidine-5-)-methyltransferase activity;GO:0000049 tRNA binding;GO:0008168 methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0031167 rRNA methylation;GO:0070129 regulation of mitochondrial translation;GO:0002127 tRNA wobble base cytosine methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5D8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5D9-1", "uniprot_id": [ { "id": "ALG8_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5D9", "type": "external" } ], "mass": 59964.0, "length": 526, "protein_name": "Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase", "gene_name": "ALG8", "organism": "Bovine", "refseq_name": "dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase", "refseq_ac": [ { "id": "NP_001069593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069593", "type": "external" } ], "gene_names_uniprotkb": "ALG8", "gene_names_refseq": "ALG8", "protein_names_uniprotkb": "Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; 2.4.1.265; Asparagine-linked glycosylation protein 8 homolog; Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase; Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase", "protein_names_refseq": "asparagine-linked glycosylation 8 homolog (S. cerevisiae, alpha-1,3-glucosyltransferase); asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog; asparagine-linked glycosylation protein 8 homolog; dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase; dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase; probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:538731)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the second glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(1)Man(9)GlcNAc(2)-PP-Dol to produce Glc(2)Man(9)GlcNAc(2)-PP-Dol. Glc(2)Man(9)GlcNAc(2)-PP-Dol is a substrate for ALG10, the following enzyme in the biosynthetic pathway (By similarity). Required for PKD1/Polycystin-1 maturation and localization to the plasma membrane of the primary cilia (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.265", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.265", "type": "external" } ], "go_molecular_function": "GO:0042283 dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006488 dolichol-linked oligosaccharide biosynthetic process;GO:0006487 protein N-linked glycosylation", "synthesized_glycan_count": 81, "hit_score": 0.1, "record_id": "Q0P5D9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5E6-1", "uniprot_id": [ { "id": "SNTA1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5E6", "type": "external" } ], "mass": 53873.0, "length": 505, "protein_name": "Alpha-1-syntrophin", "gene_name": "SNTA1", "organism": "Bovine", "refseq_name": "alpha-1-syntrophin", "refseq_ac": [ { "id": "NP_001069366", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069366", "type": "external" } ], "gene_names_uniprotkb": "SNTA1", "gene_names_refseq": "SNTA1", "protein_names_uniprotkb": "Alpha-1-syntrophin", "protein_names_refseq": "alpha-1-syntrophin; syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)", "tax_id": 9913, "disease": "", "pathway": " (bta:527488); (R-BTA-9913351)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0017080 sodium channel regulator activity;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0005856 cytoskeleton;GO:0031594 neuromuscular junction;GO:0042383 sarcolemma;GO:0070161 anchoring junction", "go_biological_process": "GO:0086005 ventricular cardiac muscle cell action potential", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5E6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5F0-1", "uniprot_id": [ { "id": "PPAL_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5F0", "type": "external" } ], "mass": 48302.0, "length": 423, "protein_name": "Lysosomal acid phosphatase", "gene_name": "ACP2", "organism": "Bovine", "refseq_name": "lysosomal acid phosphatase isoform 1 precursor", "refseq_ac": [ { "id": "NP_001069526", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069526", "type": "external" } ], "gene_names_uniprotkb": "ACP2", "gene_names_refseq": "ACP2", "protein_names_uniprotkb": "Lysosomal acid phosphatase; 3.1.3.2; LAP", "protein_names_refseq": "LAP; lysosomal acid phosphatase isoform 1 precursor; lysosomal acid phosphatase", "tax_id": 9913, "disease": "", "pathway": " (bta:535407)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Two isoforms are predicted to be produced from the same mRNA by the use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017]., [RefSeq]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" } ], "go_molecular_function": "GO:0003993 acid phosphatase activity", "go_cellular_component": "GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0007040 lysosome organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5F0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5F9-1", "uniprot_id": [ { "id": "AL8A1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5F9", "type": "external" } ], "mass": 53363.0, "length": 487, "protein_name": "2-aminomuconic semialdehyde dehydrogenase", "gene_name": "ALDH8A1", "organism": "Bovine", "refseq_name": "2-aminomuconic semialdehyde dehydrogenase", "refseq_ac": [ { "id": "NP_001069094", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069094", "type": "external" } ], "gene_names_uniprotkb": "ALDH8A1", "gene_names_refseq": "ALDH8A1", "protein_names_uniprotkb": "2-aminomuconic semialdehyde dehydrogenase; 1.2.1.32; Aldehyde dehydrogenase family 8 member A1", "protein_names_refseq": "2-aminomuconic semialdehyde dehydrogenase; aldehyde dehydrogenase 8A1; aldehyde dehydrogenase family 8 member A1", "tax_id": 9913, "disease": "", "pathway": " (bta:513537)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L594", "ec_number_list": [ { "id": "1.2.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.32", "type": "external" } ], "go_molecular_function": "GO:0001758 retinal dehydrogenase (NAD+) activity;GO:0047102 aminomuconate-semialdehyde dehydrogenase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0097053 L-kynurenine catabolic process;GO:0042573 retinoic acid metabolic process;GO:0042574 retinal metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0P5F9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5G1-1", "uniprot_id": [ { "id": "TONSL_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5G1", "type": "external" } ], "mass": 150245.0, "length": 1374, "protein_name": "Tonsoku-like protein", "gene_name": "TONSL", "organism": "Bovine", "refseq_name": "tonsoku-like protein", "refseq_ac": [ { "id": "NP_001068656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068656", "type": "external" } ], "gene_names_uniprotkb": "TONSL; IKBR; NFKBIL2", "gene_names_refseq": "NFKBIL2; TONSL", "protein_names_uniprotkb": "Tonsoku-like protein; I-kappa-B-related protein; IkappaBR; Inhibitor of kappa B-related protein; NF-kappa-B inhibitor-like protein 2; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2", "protein_names_refseq": "I-kappa-B-related protein; NF-kappa-B inhibitor-like protein 2; ikappaBR; inhibitor of kappa B-related protein; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2; tonsoku-like protein", "tax_id": 9913, "disease": "", "pathway": " (bta:505102)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication. It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs. Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination. Within the complex, TONSL acts as a histone reader, which recognizes and binds newly synthesized histones following their replacement by histone chaperones. Specifically binds histone H4 lacking methylation at 'Lys-20' (H4K20me0) and histone H3.1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042393 histone binding;GO:0140566 histone reader activity", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005737 cytoplasm;GO:0035861 site of double-strand break", "go_biological_process": "GO:0000724 double-strand break repair via homologous recombination;GO:0031297 replication fork processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5G1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5H2-1", "uniprot_id": [ { "id": "TDIF2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5H2", "type": "external" } ], "mass": 86798.0, "length": 766, "protein_name": "Deoxynucleotidyltransferase terminal-interacting protein 2", "gene_name": "DNTTIP2", "organism": "Bovine", "refseq_name": "deoxynucleotidyltransferase terminal-interacting protein 2", "refseq_ac": [ { "id": "NP_001068974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068974", "type": "external" } ], "gene_names_uniprotkb": "DNTTIP2", "gene_names_refseq": "DNTTIP2", "protein_names_uniprotkb": "Deoxynucleotidyltransferase terminal-interacting protein 2", "protein_names_refseq": "deoxynucleotidyltransferase terminal-interacting protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:511258)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006396 RNA processing;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5H2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5H5-1", "uniprot_id": [ { "id": "RGS2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5H5", "type": "external" } ], "mass": 24210.0, "length": 211, "protein_name": "Regulator of G protein signaling 2", "gene_name": "RGS2", "organism": "Bovine", "refseq_name": "regulator of G-protein signaling 2", "refseq_ac": [ { "id": "NP_001069064", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069064", "type": "external" } ], "gene_names_uniprotkb": "RGS2", "gene_names_refseq": "LOC513055; RGS2", "protein_names_uniprotkb": "Regulator of G protein signaling 2; RGS2", "protein_names_refseq": "regulator of G-protein signaling 2", "tax_id": 9913, "disease": "", "pathway": " (bta:513055)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0006417 regulation of translation;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5H5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5I2-1", "uniprot_id": [ { "id": "IRAK2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5I2", "type": "external" } ], "mass": 68630.0, "length": 621, "protein_name": "Interleukin-1 receptor-associated kinase-like 2", "gene_name": "IRAK2", "organism": "Bovine", "refseq_name": "interleukin-1 receptor-associated kinase-like 2", "refseq_ac": [ { "id": "NP_001069164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069164", "type": "external" } ], "gene_names_uniprotkb": "IRAK2", "gene_names_refseq": "IRAK-2; IRAK2", "protein_names_uniprotkb": "Interleukin-1 receptor-associated kinase-like 2; IRAK-2", "protein_names_refseq": "interleukin-1 receptor-associated kinase-like 2", "tax_id": 9913, "disease": "", "pathway": " (bta:515034); (R-BTA-445989); (R-BTA-450302); (R-BTA-450321); (R-BTA-9020702); (R-BTA-937042); (R-BTA-937072); (R-BTA-975163)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "31722768", "class_list": "", "function": "Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; It was concluded that miR-15a and miR-15a target genes (IRAK2) constitute potential miRNA-mRNA regulatory pairs for use as biomarkers to predict a mastitis response., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:0035556 intracellular signal transduction;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0031663 lipopolysaccharide-mediated signaling pathway;GO:0008063 Toll signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0P5I2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5J4-1", "uniprot_id": [ { "id": "K1C25_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5J4", "type": "external" } ], "mass": 49313.0, "length": 450, "protein_name": "Keratin, type I cytoskeletal 25", "gene_name": "KRT25", "organism": "Bovine", "refseq_name": "keratin, type I cytoskeletal 25", "refseq_ac": [ { "id": "NP_001068991", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068991", "type": "external" } ], "gene_names_uniprotkb": "KRT25", "gene_names_refseq": "KRT25", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 25; CK-25; Cytokeratin-25; K25; Keratin-25; Type I inner root sheath-specific keratin-K25irs1", "protein_names_refseq": "CK-25; K25; cytokeratin-25; keratin, type I cytoskeletal 25; type I inner root sheath-specific keratin-K25irs1", "tax_id": 9913, "disease": "", "pathway": " (bta:511540); (R-BTA-6805567); (R-BTA-6809371)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "41018975", "class_list": "", "function": "Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0007010 cytoskeleton organization;GO:0045109 intermediate filament organization;GO:0031069 hair follicle morphogenesis;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q0P5J4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5J6-1", "uniprot_id": [ { "id": "K1C27_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5J6", "type": "external" } ], "mass": 49907.0, "length": 460, "protein_name": "Keratin, type I cytoskeletal 27", "gene_name": "KRT27", "organism": "Bovine", "refseq_name": "keratin, type I cytoskeletal 27", "refseq_ac": [ { "id": "NP_001069283", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069283", "type": "external" } ], "gene_names_uniprotkb": "KRT27", "gene_names_refseq": "CK-27; K27; KRT27", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 27; CK-27; Cytokeratin-27; K27; Keratin-27; Type I inner root sheath-specific keratin-K25irs3", "protein_names_refseq": "cytokeratin-27; keratin, type I cytoskeletal 27; type I inner root sheath-specific keratin-K25irs3", "tax_id": 9913, "disease": "", "pathway": " (bta:521074); (R-BTA-6805567); (R-BTA-6809371)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "29932459", "class_list": "", "function": "A mutation in keratin 27 causes a curly coat phenotype in German Angus cattle, [RefSeq, PubMed]; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0031069 hair follicle morphogenesis;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0P5J6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5J7-1", "uniprot_id": [ { "id": "KRT35_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5J7", "type": "external" } ], "mass": 49937.0, "length": 454, "protein_name": "Keratin, type I cuticular Ha5", "gene_name": "KRT35", "organism": "Bovine", "refseq_name": "keratin, type I cuticular Ha5", "refseq_ac": [ { "id": "NP_001069541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069541", "type": "external" } ], "gene_names_uniprotkb": "KRT35", "gene_names_refseq": "KRT35", "protein_names_uniprotkb": "Keratin, type I cuticular Ha5; K35; Keratin-35", "protein_names_refseq": "K35; keratin, type I cuticular Ha5", "tax_id": 9913, "disease": "", "pathway": " (bta:536311)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5J7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5J8-1", "uniprot_id": [ { "id": "STRP1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5J8", "type": "external" } ], "mass": 95687.0, "length": 837, "protein_name": "Striatin-interacting protein 1", "gene_name": "STRIP1", "organism": "Bovine", "refseq_name": "striatin-interacting protein 1", "refseq_ac": [ { "id": "NP_001068964", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068964", "type": "external" } ], "gene_names_uniprotkb": "STRIP1; FAM40A", "gene_names_refseq": "FAM40A; STRIP1", "protein_names_uniprotkb": "Striatin-interacting protein 1; Protein FAM40A", "protein_names_refseq": "family with sequence similarity 40, member A; protein FAM40A; striatin-interacting protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:511120)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0019901 protein kinase binding;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0090443 FAR/SIN/STRIPAK complex;GO:0005737 cytoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0007010 cytoskeleton organization;GO:0035331 negative regulation of hippo signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5J8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5K4-1", "uniprot_id": [ { "id": "TOX4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5K4", "type": "external" } ], "mass": 66087.0, "length": 619, "protein_name": "TOX high mobility group box family member 4", "gene_name": "TOX4", "organism": "Bovine", "refseq_name": "TOX high mobility group box family member 4", "refseq_ac": [ { "id": "NP_001069175", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069175", "type": "external" } ], "gene_names_uniprotkb": "TOX4", "gene_names_refseq": "TOX4", "protein_names_uniprotkb": "TOX high mobility group box family member 4", "protein_names_refseq": "TOX high mobility group box family member 4; epidermal Langerhans cell protein LCP1", "tax_id": 9913, "disease": "", "pathway": " (bta:515314)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate. In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1. This regulation is independent of the insulin receptor activation. Also acts as a regulatory component of protein phosphatase 1 (PP1) complexes. Component of the PNUTS-PP1 protein phosphatase complex, a PP1 complex that regulates RNA polymerase II transcription pause-release (By similarity). PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0072357 PTW/PP1 phosphatase complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0001111 RNA polymerase II promoter clearance;GO:0032968 positive regulation of transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5K4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5L0-1", "uniprot_id": [ { "id": "RBM42_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5L0", "type": "external" } ], "mass": 47187.0, "length": 448, "protein_name": "RNA-binding protein 42", "gene_name": "RBM42", "organism": "Bovine", "refseq_name": "RNA-binding protein 42", "refseq_ac": [ { "id": "NP_001069673", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069673", "type": "external" } ], "gene_names_uniprotkb": "RBM42", "gene_names_refseq": "RBM42", "protein_names_uniprotkb": "RNA-binding protein 42; RNA-binding motif protein 42", "protein_names_refseq": "RNA-binding protein 42", "tax_id": 9913, "disease": "", "pathway": " (bta:540172)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5L0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V881-1", "uniprot_id": [ { "id": "LY66F_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V881", "type": "external" } ], "mass": 32432.0, "length": 299, "protein_name": "Lymphocyte antigen 6 complex locus protein G6f", "gene_name": "LY6G6F", "organism": "Bovine", "refseq_name": "lymphocyte antigen 6 complex locus protein G6f precursor", "refseq_ac": [ { "id": "NP_001069662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069662", "type": "external" } ], "gene_names_uniprotkb": "LY6G6F; G6F", "gene_names_refseq": "C6ORF21; G6F; LY6G6F", "protein_names_uniprotkb": "Lymphocyte antigen 6 complex locus protein G6f", "protein_names_refseq": "lymphocyte antigen 6 complex locus protein G6f precursor; lymphocyte antigen 6 complex locus protein G6f; lymphocyte antigen 6 complex, locus G6F", "tax_id": 9913, "disease": "", "pathway": " (bta:539920)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "May play a role in the downstream signal transduction pathways involving GRB2 and GRB7., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0V881-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V8A3-1", "uniprot_id": [ { "id": "CAST1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V8A3", "type": "external" } ], "mass": 36041.0, "length": 329, "protein_name": "Cytosolic arginine sensor for mTORC1 subunit 1", "gene_name": "CASTOR1", "organism": "Bovine", "refseq_name": "cytosolic arginine sensor for mTORC1 subunit 1", "refseq_ac": [ { "id": "NP_001074983", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074983", "type": "external" } ], "gene_names_uniprotkb": "CASTOR1; GATSL3", "gene_names_refseq": "CASTOR1; GATSL3", "protein_names_uniprotkb": "Cytosolic arginine sensor for mTORC1 subunit 1; GATS-like protein 3", "protein_names_refseq": "GATS protein like 3; GATS-like protein 3; cytosolic arginine sensor for mTORC1 subunit 1", "tax_id": 9913, "disease": "", "pathway": " (bta:506974); (R-BTA-9639288)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0034618 arginine binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:1903577 cellular response to L-arginine;GO:1904262 negative regulation of TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0V8A3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V8C2-1", "uniprot_id": [ { "id": "EXOC3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V8C2", "type": "external" } ], "mass": 85581.0, "length": 745, "protein_name": "Exocyst complex component 3", "gene_name": "EXOC3", "organism": "Bovine", "refseq_name": "exocyst complex component 3", "refseq_ac": [ { "id": "NP_001069068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069068", "type": "external" } ], "gene_names_uniprotkb": "EXOC3; SEC6", "gene_names_refseq": "EXOC3", "protein_names_uniprotkb": "Exocyst complex component 3; Exocyst complex component Sec6", "protein_names_refseq": "Sec6 protein; exocyst complex component 3; exocyst complex component Sec6", "tax_id": 9913, "disease": "", "pathway": " (bta:513138); (R-BTA-264876); (R-BTA-5620916)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0030426 growth cone;GO:0048471 perinuclear region of cytoplasm;GO:0030496 midbody", "go_biological_process": "GO:0051601 exocyst localization;GO:0015031 protein transport;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0V8C2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V8F1-1", "uniprot_id": [ { "id": "CORO7_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V8F1", "type": "external" } ], "mass": 99252.0, "length": 915, "protein_name": "Coronin-7", "gene_name": "CORO7", "organism": "Bovine", "refseq_name": "coronin-7", "refseq_ac": [ { "id": "NP_001069371", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069371", "type": "external" } ], "gene_names_uniprotkb": "CORO7", "gene_names_refseq": "CORO7", "protein_names_uniprotkb": "Coronin-7; Crn7", "protein_names_refseq": "coronin-7; crn7", "tax_id": 9913, "disease": "", "pathway": " (bta:527934)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0007015 actin filament organization;GO:0015031 protein transport;GO:0016477 cell migration;GO:0030041 actin filament polymerization;GO:0006895 Golgi to endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0V8F1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V8G3-1", "uniprot_id": [ { "id": "QPCTL_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V8G3", "type": "external" } ], "mass": 42898.0, "length": 383, "protein_name": "Glutaminyl-peptide cyclotransferase-like protein", "gene_name": "QPCTL", "organism": "Bovine", "refseq_name": "glutaminyl-peptide cyclotransferase-like protein", "refseq_ac": [ { "id": "NP_001069408", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069408", "type": "external" } ], "gene_names_uniprotkb": "QPCTL", "gene_names_refseq": "QPCTL; gQC", "protein_names_uniprotkb": "Glutaminyl-peptide cyclotransferase-like protein; 2.3.2.5; Golgi-resident glutaminyl-peptide cyclotransferase; gQC; isoQC", "protein_names_refseq": "glutaminyl-peptide cyclotransferase-like protein; golgi-resident glutaminyl-peptide cyclotransferase; isoQC", "tax_id": 9913, "disease": "", "pathway": " (bta:530871)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Responsible for the biosynthesis of pyroglutamyl peptides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1JP99;Q1JPE4", "ec_number_list": [ { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016603 glutaminyl-peptide cyclotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0V8G3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V8R7-1", "uniprot_id": [ { "id": "NSUN4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V8R7", "type": "external" } ], "mass": 43199.0, "length": 384, "protein_name": "5-cytosine rRNA methyltransferase NSUN4", "gene_name": "NSUN4", "organism": "Bovine", "refseq_name": "5-cytosine rRNA methyltransferase NSUN4", "refseq_ac": [ { "id": "NP_001178310", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178310", "type": "external" } ], "gene_names_uniprotkb": "NSUN4", "gene_names_refseq": "NSUN4", "protein_names_uniprotkb": "5-cytosine rRNA methyltransferase NSUN4; 2.1.1.-; 5-cytosine tRNA methyltransferase NSUN4; NOL1/NOP2/Sun domain family member 4", "protein_names_refseq": "5-cytosine rRNA methyltransferase NSUN4; 5-cytosine tRNA methyltransferase NSUN4; 5-methylcytosine rRNA methyltransferase NSUN4; 5-methylcytosine tRNA methyltransferase NSUN4; NOL1/NOP2/Sun domain family 4 protein; NOL1/NOP2/Sun domain family, member 4; NOP2/Sun RNA methyltransferase family member 4; putative methyltransferase NSUN4", "tax_id": 9913, "disease": "", "pathway": " (bta:618779)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Mitochondrial RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as rRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (By similarity). Involved in mitochondrial ribosome small subunit (SSU) maturation by catalyzing methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU) (By similarity). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled (By similarity). In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4 (By similarity). Also acts as a regulator of innate immunity by marking double-stranded mitochondrial RNAs(mt-dsRNAs) generated in response to stress: catalyzes m5C modification on mitochondrial RNAs, such as a mRNAs and lncRNAs, with a preference for the termini of light-strand lncRNAs, promoting their degradation and cytosolic release (By similarity). Modified light-strand lncRNAs are then recognized by C1QBP reader and recruited to the mitochondrial degradosome complex, which promotes their degradation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.203", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.203", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0008168 methyltransferase activity;GO:0019843 rRNA binding;GO:0062152 mRNA (cytidine-5-)-methyltransferase activity;GO:0008649 rRNA methyltransferase activity;GO:1990400 mitochondrial ribosomal large subunit rRNA binding", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0031167 rRNA methylation;GO:0000957 mitochondrial RNA catabolic process;GO:1902775 mitochondrial large ribosomal subunit assembly;GO:1900864 mitochondrial RNA modification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0V8R7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VBY1-1", "uniprot_id": [ { "id": "ODF2L_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VBY1", "type": "external" } ], "mass": 63862.0, "length": 548, "protein_name": "Protein BCAP", "gene_name": "ODF2L", "organism": "Bovine", "refseq_name": "protein BCAP", "refseq_ac": [ { "id": "NP_001069461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069461", "type": "external" } ], "gene_names_uniprotkb": "ODF2L; BCAP", "gene_names_refseq": "ODF2L", "protein_names_uniprotkb": "Protein BCAP; Basal body centriole-associated protein; Outer dense fiber protein 2-like", "protein_names_refseq": "basal body centriole-associated protein; outer dense fiber protein 2-like; protein BCAP", "tax_id": 9913, "disease": "", "pathway": " (bta:533508)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a suppressor of ciliogenesis, specifically, the initiation of ciliogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005814 centriole;GO:0034451 centriolar satellite;GO:0036064 ciliary basal body", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0030030 cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VBY1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VBY7-1", "uniprot_id": [ { "id": "DJC24_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VBY7", "type": "external" } ], "mass": 17135.0, "length": 149, "protein_name": "DnaJ homolog subfamily C member 24", "gene_name": "DNAJC24", "organism": "Bovine", "refseq_name": "dnaJ homolog subfamily C member 24", "refseq_ac": [ { "id": "NP_001071570", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071570", "type": "external" } ], "gene_names_uniprotkb": "DNAJC24; DPH4; ZCSL3", "gene_names_refseq": "DNAJC24; DPH4; ZCSL3", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 24; CSL-type zinc finger-containing protein 3; Diphthamide biosynthesis protein 4", "protein_names_refseq": "CSL-type zinc finger-containing protein 3; DPH4 homolog; DPH4, JJJ3 homolog; DnaJ (Hsp40) homolog, subfamily C, member 24; diphthamide biosynthesis protein 4; dnaJ homolog subfamily C member 24; zinc finger, CSL-type containing 3", "tax_id": 9913, "disease": "", "pathway": " (bta:768227)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron-bound form is redox-active and can function as electron carrier. Plays a role in the diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008198 ferrous iron binding;GO:0001671 ATPase activator activity", "go_cellular_component": "GO:0005856 cytoskeleton", "go_biological_process": "GO:0032781 positive regulation of ATP-dependent activity;GO:0017183 protein histidyl modification to diphthamide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VBY7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VBZ9-1", "uniprot_id": [ { "id": "MRP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VBZ9", "type": "external" } ], "mass": 19825.0, "length": 198, "protein_name": "MARCKS-related protein", "gene_name": "MARCKSL1", "organism": "Bovine", "refseq_name": "MARCKS-related protein", "refseq_ac": [ { "id": "NP_001069640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069640", "type": "external" } ], "gene_names_uniprotkb": "MARCKSL1", "gene_names_refseq": "MARCKSL1", "protein_names_uniprotkb": "MARCKS-related protein; MARCKS-like protein 1", "protein_names_refseq": "MARCKS-like protein 1; MARCKS-related protein", "tax_id": 9913, "disease": "", "pathway": " (bta:539555)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 18, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0007015 actin filament organization;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VBZ9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC13-1", "uniprot_id": [ { "id": "ADAL_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC13", "type": "external" } ], "mass": 39646.0, "length": 351, "protein_name": "N6-Methyl-AMP deaminase", "gene_name": "MAPDA", "organism": "Bovine", "refseq_name": "N6-Methyl-AMP deaminase", "refseq_ac": [ { "id": "NP_001069045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069045", "type": "external" } ], "gene_names_uniprotkb": "MAPDA; ADAL", "gene_names_refseq": "ADAL; MAPDA", "protein_names_uniprotkb": "N6-Methyl-AMP deaminase; 3.5.4.-; Adenosine deaminase-like protein; N6,N6-dimethyl-AMP deaminase; N6-isopentenyl-AMP deaminase", "protein_names_refseq": "N6,N6-dimethyl-AMP deaminase; N6-Methyl-AMP deaminase; N6-isopentenyl-AMP deaminase; adenosine deaminase-like protein", "tax_id": 9913, "disease": "", "pathway": " (bta:512667)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Deaminase involved in the detoxification of modified adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification. Modified nucleosides are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs) and possess intrinsic cytotoxicity and must be cleared to prevent metabolic dysfunction. Acts downstream of ADK and catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotides N(6)-methyl-AMP (m6AMP), N(6),N(6)-dimethyl-AMP (m6,6AMP) and N(6)-isopentenyl-AMP (i6AMP) to produce inositol monophosphate (IMP). Catalyzes the removal of different alkyl groups not only from N6-substituted purine or 2-aminopurine nucleoside monophosphates but also from O6-substituted compounds in vitro., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.-", "type": "external" } ], "go_molecular_function": "GO:0004000 adenosine deaminase activity;GO:0046872 metal ion binding;GO:0062154 N6-methyl-AMP deaminase activity", "go_cellular_component": "", "go_biological_process": "GO:0006154 adenosine catabolic process;GO:0009117 nucleotide metabolic process;GO:0046103 inosine biosynthetic process;GO:0110052 toxic metabolite repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VC13-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC18-1", "uniprot_id": [ { "id": "ARL4D_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC18", "type": "external" } ], "mass": 22126.0, "length": 200, "protein_name": "ADP-ribosylation factor-like protein 4D", "gene_name": "ARL4D", "organism": "Bovine", "refseq_name": "ADP-ribosylation factor-like protein 4D", "refseq_ac": [ { "id": "NP_001069603", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069603", "type": "external" } ], "gene_names_uniprotkb": "ARL4D", "gene_names_refseq": "ARL4D", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 4D", "protein_names_refseq": "ADP-ribosylation factor-like 4D; ADP-ribosylation factor-like protein 4D", "tax_id": 9913, "disease": "", "pathway": " (bta:538936)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VC18-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC22-1", "uniprot_id": [ { "id": "NAR5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC22", "type": "external" } ], "mass": 34894.0, "length": 316, "protein_name": "Ecto-ADP-ribosyltransferase 5", "gene_name": "ART5", "organism": "Bovine", "refseq_name": "ecto-ADP-ribosyltransferase 5 precursor", "refseq_ac": [ { "id": "NP_001069983", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069983", "type": "external" } ], "gene_names_uniprotkb": "ART5", "gene_names_refseq": "ART5; ARTC5; LOC618664", "protein_names_uniprotkb": "Ecto-ADP-ribosyltransferase 5; 2.4.2.31; ADP-ribosyltransferase C2 and C3 toxin-like 5; ARTC5; Mono(ADP-ribosyl)transferase 5; NAD(P)(+)--arginine ADP-ribosyltransferase 5", "protein_names_refseq": "ADP-ribosyltransferase C2 and C3 toxin-like 5; NAD(P)(+)--arginine ADP-ribosyltransferase 5; ecto-ADP-ribosyltransferase 5 precursor; ecto-ADP-ribosyltransferase 5; mono(ADP-ribosyl)transferase 5", "tax_id": 9913, "disease": "", "pathway": " (bta:618664)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" } ], "go_molecular_function": "GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity;GO:0106274 NAD+-protein-arginine ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VC22-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC24-1", "uniprot_id": [ { "id": "WDR12_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC24", "type": "external" } ], "mass": 47709.0, "length": 423, "protein_name": "Ribosome biogenesis protein WDR12", "gene_name": "WDR12", "organism": "Bovine", "refseq_name": "ribosome biogenesis protein WDR12", "refseq_ac": [ { "id": "NP_001069375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069375", "type": "external" } ], "gene_names_uniprotkb": "WDR12", "gene_names_refseq": "WDR12", "protein_names_uniprotkb": "Ribosome biogenesis protein WDR12; WD repeat-containing protein 12", "protein_names_refseq": "WD repeat domain 12 protein; ribosome biogenesis protein WDR12", "tax_id": 9913, "disease": "", "pathway": " (bta:528209); (R-BTA-6791226)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PJI2", "ec_number_list": [], "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0070545 PeBoW complex", "go_biological_process": "GO:0051726 regulation of cell cycle;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0VC24-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC30-1", "uniprot_id": [ { "id": "DPOG2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC30", "type": "external" } ], "mass": 54663.0, "length": 485, "protein_name": "DNA polymerase subunit gamma-2", "gene_name": "POLG2", "organism": "Bovine", "refseq_name": "DNA polymerase subunit gamma-2", "refseq_ac": [ { "id": "NP_001068659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068659", "type": "external" } ], "gene_names_uniprotkb": "POLG2; MTPOLB", "gene_names_refseq": "POLG2", "protein_names_uniprotkb": "DNA polymerase subunit gamma-2; Mitochondrial DNA polymerase accessory subunit; MtPolB; PolG-beta", "protein_names_refseq": "DNA polymerase subunit gamma-2, mitochondrial; DNA polymerase subunit gamma-2; mitochondrial DNA polymerase accessory subunit; mtPolB; polG-beta; polymerase (DNA directed), gamma 2, accessory subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:505152); (R-BTA-9913635)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accessory subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Acts as an allosteric regulator of the holoenzyme activities. Enhances the polymerase activity and the processivity of POLG by increasing its interactions with the DNA template. Suppresses POLG exonucleolytic proofreading especially toward homopolymeric templates bearing mismatched termini. Binds to single-stranded DNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030337 DNA polymerase processivity factor activity;GO:0003677 DNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0042645 mitochondrial nucleoid;GO:0005760 gamma DNA polymerase complex", "go_biological_process": "GO:0006264 mitochondrial DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VC30-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC48-1", "uniprot_id": [ { "id": "TMOD4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC48", "type": "external" } ], "mass": 39184.0, "length": 345, "protein_name": "Tropomodulin-4", "gene_name": "TMOD4", "organism": "Bovine", "refseq_name": "tropomodulin-4", "refseq_ac": [ { "id": "NP_001068683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068683", "type": "external" } ], "gene_names_uniprotkb": "TMOD4", "gene_names_refseq": "TMOD4", "protein_names_uniprotkb": "Tropomodulin-4; Sk-Tmod; Skeletal muscle tropomodulin", "protein_names_refseq": "sk-Tmod; skeletal muscle tropomodulin; tropomodulin 4 (muscle); tropomodulin-4", "tax_id": 9913, "disease": "", "pathway": " (bta:505645); (R-BTA-390522)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005523 tropomyosin binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005865 striated muscle thin filament;GO:0030016 myofibril", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization;GO:0051694 pointed-end actin filament capping;GO:0030239 myofibril assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VC48-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC53-1", "uniprot_id": [ { "id": "DOHH_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC53", "type": "external" } ], "mass": 33261.0, "length": 303, "protein_name": "Deoxyhypusine hydroxylase", "gene_name": "DOHH", "organism": "Bovine", "refseq_name": "deoxyhypusine hydroxylase", "refseq_ac": [ { "id": "NP_001069354", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069354", "type": "external" } ], "gene_names_uniprotkb": "DOHH", "gene_names_refseq": "DOHH", "protein_names_uniprotkb": "Deoxyhypusine hydroxylase; 1.14.99.29; DOHH; Deoxyhypusine dioxygenase; Deoxyhypusine monooxygenase", "protein_names_refseq": "deoxyhypusine dioxygenase; deoxyhypusine hydroxylase/monooxygenase; deoxyhypusine hydroxylase; deoxyhypusine monooxygenase", "tax_id": 9913, "disease": "", "pathway": " (bta:526521); (R-BTA-204626)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "17391984", "class_list": "", "function": "Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function., [UniProtKB, PubMed, HAMAP]; We describe the cloning and characterization of bovine deoxyhypusine hydroxylase cDNA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5H2K6;A5H2K8", "ec_number_list": [ { "id": "1.14.99.29", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.29", "type": "external" } ], "go_molecular_function": "GO:0019135 deoxyhypusine monooxygenase activity;GO:0005506 iron ion binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0VC53-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC66-1", "uniprot_id": [ { "id": "CTU1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC66", "type": "external" } ], "mass": 36599.0, "length": 347, "protein_name": "Cytoplasmic tRNA 2-thiolation protein 1", "gene_name": "CTU1", "organism": "Bovine", "refseq_name": "cytoplasmic tRNA 2-thiolation protein 1", "refseq_ac": [ { "id": "NP_001071422", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071422", "type": "external" } ], "gene_names_uniprotkb": "CTU1; ATPBD3; NCS6", "gene_names_refseq": "ATPBD3; CTU1", "protein_names_uniprotkb": "Cytoplasmic tRNA 2-thiolation protein 1; 2.7.7.-; ATP-binding domain-containing protein 3; Cytoplasmic tRNA adenylyltransferase 1", "protein_names_refseq": "ATP binding domain 3; ATP-binding domain-containing protein 3; cytoplasmic tRNA 2-thiolation protein 1; cytoplasmic tRNA adenylyltransferase 1; cytosolic thiouridylase subunit 1 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:522824)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000049 tRNA binding;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0002144 cytosolic tRNA wobble base thiouridylase complex", "go_biological_process": "GO:0002143 tRNA wobble position uridine thiolation;GO:0034227 tRNA thio-modification;GO:0002098 tRNA wobble uridine modification;GO:0032447 protein urmylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VC66-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC80-1", "uniprot_id": [ { "id": "YRDC_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC80", "type": "external" } ], "mass": 28893.0, "length": 276, "protein_name": "Threonylcarbamoyl-AMP synthase", "gene_name": "YRDC", "organism": "Bovine", "refseq_name": "threonylcarbamoyl-AMP synthase precursor", "refseq_ac": [ { "id": "NP_001069018", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069018", "type": "external" } ], "gene_names_uniprotkb": "YRDC", "gene_names_refseq": "YRDC", "protein_names_uniprotkb": "Threonylcarbamoyl-AMP synthase; 2.7.7.87", "protein_names_refseq": "threonylcarbamoyl-AMP synthase precursor; threonylcarbamoyl-AMP synthase; yrdC domain containing; yrdC domain-containing protein, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:512062); (R-BTA-6787450)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cytoplasmic and mitochondrial threonylcarbamoyl-AMP synthase required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Participates in t(6)A37 formation in cytoplasmic and mitochondrial tRNAs (By similarity). May regulate the activity of some transporters (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.87", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.87", "type": "external" } ], "go_molecular_function": "GO:0000049 tRNA binding;GO:0003725 double-stranded RNA binding;GO:0016779 nucleotidyltransferase activity;GO:0061710 L-threonylcarbamoyladenylate synthase", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane", "go_biological_process": "GO:0002949 tRNA threonylcarbamoyladenosine modification;GO:0006450 regulation of translational fidelity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VC80-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC85-1", "uniprot_id": [ { "id": "PHLA2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC85", "type": "external" } ], "mass": 15868.0, "length": 142, "protein_name": "Pleckstrin homology-like domain family A member 2", "gene_name": "PHLDA2", "organism": "Bovine", "refseq_name": "pleckstrin homology-like domain family A member 2", "refseq_ac": [ { "id": "NP_001069989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069989", "type": "external" } ], "gene_names_uniprotkb": "PHLDA2; IPL", "gene_names_refseq": "PHLDA2", "protein_names_uniprotkb": "Pleckstrin homology-like domain family A member 2; Imprinted in placenta and liver protein", "protein_names_refseq": "imprinted in placenta and liver protein; pleckstrin homology-like domain family A member 2", "tax_id": 9913, "disease": "", "pathway": " (bta:618810)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22497461;23894493;26440077;28442058", "class_list": "", "function": "Genes critical for placental development were altered in nuclear transfer placentas, including an imprinted gene. Allele-specific changes in the permissive histone mark in the PHLDA2 promoter indicate misregulation of imprinting in clones., [RefSeq, PubMed]; Imprinting status of four cattle genes (Tssc4,Nap1l4, Phlda2 and Osbpl5) in seven types of tissues, were assessed in cattle., [RefSeq, PubMed]; Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity)., [UniProtKB]; Pleckstrin homology-like domain family A member 2 (PHLDA2) gene is expressed across a range of cattle fetal tissues and stages. It provides the first evidence that PHLDA2 is a monoallelically expressed imprinted gene in cattle fetal tissues and placenta., [RefSeq, PubMed]; Proper expression levels of the imprinted genes CDKN1C and PHLDA2 are critical for embryo development Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1901981 phosphatidylinositol phosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0001890 placenta development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q0VC85-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC92-1", "uniprot_id": [ { "id": "MGN2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC92", "type": "external" } ], "mass": 17308.0, "length": 148, "protein_name": "Protein mago nashi homolog 2", "gene_name": "MAGOHB", "organism": "Bovine", "refseq_name": "protein mago nashi homolog 2", "refseq_ac": [ { "id": "NP_001069720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069720", "type": "external" } ], "gene_names_uniprotkb": "MAGOHB; MAGOH2", "gene_names_refseq": "MAGOHB", "protein_names_uniprotkb": "Protein mago nashi homolog 2", "protein_names_refseq": "mago homolog B, exon junction complex core component; mago-nashi homolog 2; mago-nashi homolog B; protein mago nashi homolog 2", "tax_id": 9913, "disease": "", "pathway": " (bta:541013); (R-BTA-159236); (R-BTA-72163); (R-BTA-975957)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for pre-mRNA splicing as component of the spliceosome. Plays a redundant role with MAGOH in the exon junction complex and in the nonsense-mediated decay (NMD) pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0071013 catalytic step 2 spliceosome;GO:0071006 U2-type catalytic step 1 spliceosome;GO:0035145 exon-exon junction complex;GO:0071005 U2-type precatalytic spliceosome", "go_biological_process": "GO:0008380 RNA splicing;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000398 mRNA splicing, via spliceosome;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VC92-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCA0-1", "uniprot_id": [ { "id": "FGF18_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCA0", "type": "external" } ], "mass": 23951.0, "length": 207, "protein_name": "Fibroblast growth factor 18", "gene_name": "FGF18", "organism": "Bovine", "refseq_name": "fibroblast growth factor 18 precursor", "refseq_ac": [ { "id": "NP_001069475", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069475", "type": "external" } ], "gene_names_uniprotkb": "FGF18", "gene_names_refseq": "FGF18; FGF6A", "protein_names_uniprotkb": "Fibroblast growth factor 18; FGF-18; zFGF5", "protein_names_refseq": "FGF-18; fibroblast growth factor 18 precursor; fibroblast growth factor 6A; zFGF5", "tax_id": 9913, "disease": "", "pathway": " (bta:533929)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "20484739;23707615;25411391;30625262", "class_list": "", "function": "FGF18 is proapoptotic in vivo and may act through a mechanism involving the BBC3-MDM2 pathway., [RefSeq, PubMed]; FGF8 and FGF18 signal through divergent pathways in ovarian granulosa cells, despite reportedly similar receptor activation patterns., [RefSeq, PubMed]; Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation (By similarity)., [UniProtKB]; These data point to a unique role for FGF18 in signaling from theca cells to granulosa cells and suggest that FGF18 influences the process of atresia in ovarian follicles., [RefSeq, PubMed]; These data suggest that FGF18 may be an intraovarian factor that regulates steroidogenesis in fetal ovaries., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005105 type 1 fibroblast growth factor receptor binding;GO:0008083 growth factor activity;GO:0005111 type 2 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0030334 regulation of cell migration;GO:0022008 neurogenesis;GO:0008543 fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q0VCA0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCA9-1", "uniprot_id": [ { "id": "TMED6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCA9", "type": "external" } ], "mass": 27850.0, "length": 240, "protein_name": "Transmembrane emp24 domain-containing protein 6", "gene_name": "TMED6", "organism": "Bovine", "refseq_name": "transmembrane emp24 domain-containing protein 6 precursor", "refseq_ac": [ { "id": "NP_001069456", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069456", "type": "external" } ], "gene_names_uniprotkb": "TMED6", "gene_names_refseq": "TMED6", "protein_names_uniprotkb": "Transmembrane emp24 domain-containing protein 6; p24 family protein gamma-5; p24gamma5", "protein_names_refseq": "p24 family protein gamma-5; p24gamma5; transmembrane emp24 domain-containing protein 6 precursor; transmembrane emp24 domain-containing protein 6; transmembrane emp24 protein transport domain containing 6", "tax_id": 9913, "disease": "", "pathway": " (bta:533277)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0005789 endoplasmic reticulum membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCA9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCC5-1", "uniprot_id": [ { "id": "REPI1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCC5", "type": "external" } ], "mass": 62372.0, "length": 559, "protein_name": "DNA-binding protein REPIN1", "gene_name": "REPIN1", "organism": "Bovine", "refseq_name": "DNA-binding protein REPIN1", "refseq_ac": [ { "id": "NP_001068989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068989", "type": "external" } ], "gene_names_uniprotkb": "REPIN1", "gene_names_refseq": "REPIN1", "protein_names_uniprotkb": "DNA-binding protein REPIN1", "protein_names_refseq": "DNA-binding protein REPIN1", "tax_id": 9913, "disease": "", "pathway": " (bta:511510)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sequence-specific double-stranded DNA-binding protein. Binds ATT-rich and T-rich DNA sequences and facilitates DNA bending (By similarity). May regulate the expression of genes involved in cellular fatty acid import, including SCARB1/CD36, and genes involved in lipid droplet formation (By similarity). May regulate the expression of LCN2, and thereby influence iron metabolism and apoptosis-related pathways (By similarity). May regulate the expression of genes involved in glucose transport (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:2000191 regulation of fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCC5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCE2-1", "uniprot_id": [ { "id": "HAND1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCE2", "type": "external" } ], "mass": 23966.0, "length": 218, "protein_name": "Heart- and neural crest derivatives-expressed protein 1", "gene_name": "HAND1", "organism": "Bovine", "refseq_name": "heart- and neural crest derivatives-expressed protein 1", "refseq_ac": [ { "id": "NP_001069229", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069229", "type": "external" } ], "gene_names_uniprotkb": "HAND1", "gene_names_refseq": "HAND1", "protein_names_uniprotkb": "Heart- and neural crest derivatives-expressed protein 1", "protein_names_refseq": "heart- and neural crest derivatives-expressed protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:517952)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0001829 trophectodermal cell differentiation;GO:0060707 trophoblast giant cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCE2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCE3-1", "uniprot_id": [ { "id": "TRIB3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCE3", "type": "external" } ], "mass": 39657.0, "length": 357, "protein_name": "Tribbles homolog 3", "gene_name": "TRIB3", "organism": "Bovine", "refseq_name": "tribbles homolog 3", "refseq_ac": [ { "id": "NP_001069571", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069571", "type": "external" } ], "gene_names_uniprotkb": "TRIB3", "gene_names_refseq": "TRIB3", "protein_names_uniprotkb": "Tribbles homolog 3; TRB-3", "protein_names_refseq": "TRB-3; tribbles 3; tribbles homolog 3", "tax_id": 9913, "disease": "", "pathway": " (bta:538465); (R-BTA-165158)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress (By similarity). Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells (By similarity). Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity. Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1 (By similarity). Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases (By similarity). Can inhibit APOBEC3A editing of nuclear DNA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0003714 transcription corepressor activity;GO:0031434 mitogen-activated protein kinase kinase binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010506 regulation of autophagy;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCE3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCG9-1", "uniprot_id": [ { "id": "PTX3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCG9", "type": "external" } ], "mass": 42021.0, "length": 382, "protein_name": "Pentraxin-related protein PTX3", "gene_name": "PTX3", "organism": "Bovine", "refseq_name": "pentraxin-related protein PTX3 precursor", "refseq_ac": [ { "id": "NP_001069727", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069727", "type": "external" } ], "gene_names_uniprotkb": "PTX3", "gene_names_refseq": "PTX3", "protein_names_uniprotkb": "Pentraxin-related protein PTX3; Pentaxin-related protein PTX3", "protein_names_refseq": "pentaxin-related protein PTX3; pentraxin 3, long; pentraxin-related gene, rapidly induced by IL-1 beta; pentraxin-related protein PTX3 precursor; pentraxin-related protein PTX3", "tax_id": 9913, "disease": "", "pathway": " (bta:541148)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16769728;31842598;33901710", "class_list": "", "function": "Pentraxin 3 expression in lungs and neutrophils of calves., [RefSeq, PubMed]; Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility., [UniProtKB]; Serum H-FABP in cattle with traumatic pericarditis (TP) was significantly higher than in the control group and positively correlated with PTX-3 and thrombomodulin (TM). The serum levels of PTX-3 and TM in cattle with TP were significantly higher than in the control group., [RefSeq, PubMed]; There is an FGF2-binding domain in the N-terminal extension of PTX3 spanning the PTX3-(97-110) region, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001849 complement component C1q complex binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0045087 innate immune response;GO:0044793 host-mediated suppression of viral proces", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q0VCG9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCI2-1", "uniprot_id": [ { "id": "STX19_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCI2", "type": "external" } ], "mass": 33890.0, "length": 292, "protein_name": "Syntaxin-19", "gene_name": "STX19", "organism": "Bovine", "refseq_name": "syntaxin-19", "refseq_ac": [ { "id": "NP_001069140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069140", "type": "external" } ], "gene_names_uniprotkb": "STX19", "gene_names_refseq": "STX19", "protein_names_uniprotkb": "Syntaxin-19", "protein_names_refseq": "syntaxin-19", "tax_id": 9913, "disease": "", "pathway": " (bta:514487)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17545156", "class_list": "", "function": "Modulation of the tomosyn-syntaxin 1A interaction in response to secretagogue activation is an important mechanism allowing for dynamic regulation of the secretory response, [RefSeq, PubMed]; Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0031201 SNARE complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006887 exocytosis;GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane;GO:0048278 vesicle docking", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0VCI2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCJ6-1", "uniprot_id": [ { "id": "ZBT8A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCJ6", "type": "external" } ], "mass": 50194.0, "length": 441, "protein_name": "Zinc finger and BTB domain-containing protein 8A", "gene_name": "ZBTB8A", "organism": "Bovine", "refseq_name": "zinc finger and BTB domain-containing protein 8A", "refseq_ac": [ { "id": "NP_001069732", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069732", "type": "external" } ], "gene_names_uniprotkb": "ZBTB8A", "gene_names_refseq": "ZBTB8A; ZBTB8", "protein_names_uniprotkb": "Zinc finger and BTB domain-containing protein 8A", "protein_names_refseq": "zinc finger and BTB domain containing 8; zinc finger and BTB domain-containing protein 8A", "tax_id": 9913, "disease": "", "pathway": " (bta:541221)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCJ6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCJ8-1", "uniprot_id": [ { "id": "METL9_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCJ8", "type": "external" } ], "mass": 36536.0, "length": 318, "protein_name": "Protein-L-histidine N-pros-methyltransferase", "gene_name": "METTL9", "organism": "Bovine", "refseq_name": "protein-L-histidine N-pros-methyltransferase precursor", "refseq_ac": [ { "id": "NP_001073836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073836", "type": "external" } ], "gene_names_uniprotkb": "METTL9", "gene_names_refseq": "METTL9", "protein_names_uniprotkb": "Protein-L-histidine N-pros-methyltransferase; 2.1.1.-; Methyltransferase-like protein 9", "protein_names_refseq": "methyltransferase-like protein 9; protein-L-histidine N-pros-methyltransferase precursor; protein-L-histidine N-pros-methyltransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:787067)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein-histidine N-methyltransferase that specifically catalyzes 1-methylhistidine (pros-methylhistidine) methylation of target proteins. Specifically methylates the second His of proteins with a His-x-His (HxH) motif (where 'x' is preferably a small amino acid), while exploiting the first one as a recognition signature. Catalyzes methylation of target proteins such as S100A9, NDUFB3, SLC39A5, SLC39A7, ARMC6 and DNAJB12; 1-methylhistidine modification may affect the binding of zinc and other metals to its target proteins. Constitutes the main methyltransferase for the 1-methylhistidine modification in cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0106370 protein-L-histidine N-pros-methyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCJ8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCM0-1", "uniprot_id": [ { "id": "S10AG_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCM0", "type": "external" } ], "mass": 11776.0, "length": 103, "protein_name": "Protein S100-A16", "gene_name": "S100A16", "organism": "Bovine", "refseq_name": "protein S100-A16", "refseq_ac": [ { "id": "NP_001068686", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068686", "type": "external" } ], "gene_names_uniprotkb": "S100A16", "gene_names_refseq": "S100A16", "protein_names_uniprotkb": "Protein S100-A16; S100 calcium-binding protein A16", "protein_names_refseq": "protein S100-A16", "tax_id": 9913, "disease": "", "pathway": " (bta:505679)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Calcium-binding protein. Binds one calcium ion per monomer (By similarity). Can promote differentiation of adipocytes (in vitro) (By similarity). Overexpression in preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCM0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04696-1", "uniprot_id": [ { "id": "GNAT2_BOVIN", "url": "https://www.uniprot.org/uniprot/P04696", "type": "external" } ], "mass": 40144.0, "length": 354, "protein_name": "Guanine nucleotide-binding protein G(t) subunit alpha-2", "gene_name": "GNAT2", "organism": "Bovine", "refseq_name": "guanine nucleotide-binding protein G(t) subunit alpha-2", "refseq_ac": [ { "id": "NP_776751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776751", "type": "external" } ], "gene_names_uniprotkb": "GNAT2", "gene_names_refseq": "GNAT2; HG1D", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(t) subunit alpha-2; Transducin alpha-2 chain", "protein_names_refseq": "guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2; guanine nucleotide-binding protein G(t) subunit alpha-2; heterotrimeric guanine nucleotide-binding protein 1D; transducin alpha-2 chain", "tax_id": 9913, "disease": "", "pathway": " (bta:281795); (R-BTA-4086398); (R-BTA-418594)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "3856323;6586721", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0050908 detection of light stimulus involved in visual perception;GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P04696-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68107-1", "uniprot_id": [ { "id": "FKB1B_BOVIN", "url": "https://www.uniprot.org/uniprot/P68107", "type": "external" } ], "mass": 11783.0, "length": 108, "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP1B", "gene_name": "FKBP1B", "organism": "Bovine", "refseq_name": "peptidyl-prolyl cis-trans isomerase FKBP1B", "refseq_ac": [ { "id": "NP_001091627", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091627", "type": "external" } ], "gene_names_uniprotkb": "FKBP1B; FKBP12.6", "gene_names_refseq": "FKBP12.6; FKBP1B", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase FKBP1B; 12.6 kDa FK506-binding protein; 12.6 kDa FKBP; 5.2.1.8; FK506-binding protein 1B; FKBP-12.6; FKBP-1B; Immunophilin FKBP12.6; PPIase FKBP1B; Rotamase", "protein_names_refseq": "12.6 kDa FK506-binding protein; 12.6 kDa FKBP; FK506 binding protein 1B, 12.6 kDa; FK506-binding protein 1B; FKBP-12.6; FKBP-1B; Immunophilin FKBP12.6; PPIase 1B; PPIase FKBP1B; PPIase; Rotamase 1B; peptidyl-prolyl cis-trans isomerase 1B; peptidyl-prolyl cis-trans isomerase FKBP1B; peptidyl-prolyl cis-trans isomerase", "tax_id": 9913, "disease": "", "pathway": " (bta:785179); (R-BTA-2672351); (R-BTA-5578775)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "7520438", "class_list": "", "function": "Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D7G8;Q13664;Q16645;Q9BQ40", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.14.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.16", "type": "external" } ], "go_molecular_function": "GO:0030551 cyclic nucleotide binding;GO:0005102 signaling receptor binding;GO:0044325 transmembrane transporter binding;GO:0019855 calcium channel inhibitor activity;GO:0005528 FK506 binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0043231 intracellular membrane-bounded organelle;GO:0030018 Z disc;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0048680 positive regulation of axon regeneration;GO:0051280 negative regulation of release of sequestered calcium ion into cytosol;GO:0051284 positive regulation of sequestering of calcium ion;GO:0006939 smooth muscle contraction;GO:0007204 positive regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P68107-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35508-1", "uniprot_id": [ { "id": "KC1D_BOVIN", "url": "https://www.uniprot.org/uniprot/P35508", "type": "external" } ], "mass": 47330.0, "length": 415, "protein_name": "Casein kinase I isoform delta", "gene_name": "CSNK1D", "organism": "Bovine", "refseq_name": "casein kinase I isoform X3", "refseq_ac": [ { "id": "XP_005221107", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221107", "type": "external" } ], "gene_names_uniprotkb": "CSNK1D; HCKID", "gene_names_refseq": "CSNK1D", "protein_names_uniprotkb": "Casein kinase I isoform delta; 2.7.11.1; 2.7.11.26; CKI-delta; CKId; Tau-protein kinase CSNK1D", "protein_names_refseq": "casein kinase I isoform X3", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-204005); (R-BTA-2565942); (R-BTA-380259); (R-BTA-380270); (R-BTA-380284); (R-BTA-380320); (R-BTA-5620912); (R-BTA-6791226); (R-BTA-8854518)", "pathway_count": 9, "publication_count": 1, "publication_id_list": "1946367", "class_list": "", "function": "Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0050321 tau-protein kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0016055 Wnt signaling pathway;GO:0042752 regulation of circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P35508-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32592-1", "uniprot_id": [ { "id": "ITB2_BOVIN", "url": "https://www.uniprot.org/uniprot/P32592", "type": "external" } ], "mass": 84400.0, "length": 769, "protein_name": "Integrin beta-2", "gene_name": "ITGB2", "organism": "Bovine", "refseq_name": "integrin beta-2 precursor", "refseq_ac": [ { "id": "NP_786975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786975", "type": "external" } ], "gene_names_uniprotkb": "ITGB2; CD18", "gene_names_refseq": "CD18; ITGB2", "protein_names_uniprotkb": "Integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta", "protein_names_refseq": "Leu-CAM receptor; cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; complement receptor C3 subunit beta; integrin beta-2 precursor; integrin beta-2; integrin, beta 2 (antigen CD18 subunit (p95), lymphocyte function-associated antigen 1, integrin B2); integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); leukocyte surface protein", "tax_id": 9913, "disease": "", "pathway": " (bta:281877); (R-BTA-166016); (R-BTA-198933); (R-BTA-202733); (R-BTA-216083); (R-BTA-6798695)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "1351021;1384046;19490168;19706410;22374219;30881690", "class_list": "", "function": "Identification of numerous variations in exonic and intronic regions within the ITGB2 gene in Bos taurus and indicus screened for bovine leukocyte adhesion deficiency., [RefSeq, PubMed]; Intact signal peptide of CD18, the beta-subunit of beta2-integrins, renders ruminants susceptible to Mannheimia haemolytica leukotoxin., [RefSeq, PubMed]; Integrin ITGAL:ITGB2 is a receptor for ICAM1, ICAM2 and ICAM3. Integrin ITGAL:ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM:ITGB2 and ITGAX:ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX:ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM:ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM:ITGB2 is also a receptor for factor X. Integrin ITGAD:ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL:ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. Integrins ITGAX:ITGB2 functions as a receptor of the erythrocyte-specific adhesion molecule ICAM4 and mediates erythrophagocytosis. Integrins ITGAX:ITGB2 functions as a receptor of the neuron-specific adhesion molecule ICAM5 ensuring neuron cell-leukocyte adhesion. Integrin ITGAL:ITGB2 functions as a receptor of ICAM1 by acting as a platform at the immunological synapse to translate TCR engagement and density of the ITGAL ligand ICAM1 into graded adhesion. Integrin ITGAM:ITGB2/MAC-1 complex functions as a signaling receptor for the ligand receptor ICAM1, ensuring adhesion between stimulated neutrophils and stimulated endothelial cells. Integrin ITGAL/ITGB2 that functions as a signaling receptor of ICAM2, ensuring leukocyte cell-cell adhesion on resting cells., [UniProtKB, UniProtKB]; Loss of CD18 is associated with bovine leukocyte adhesion deficiency., [RefSeq, PubMed]; Missense variants in the CD18 signal peptide affect Leukotoxin binding. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0001540 amyloid-beta binding;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0016020 membrane;GO:0045121 membrane raft;GO:0008305 integrin complex", "go_biological_process": "GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell;GO:0007229 integrin-mediated signaling pathway;GO:0031623 receptor internalization;GO:0006909 phagocytosis;GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P32592-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68399-1", "uniprot_id": [ { "id": "CSK21_BOVIN", "url": "https://www.uniprot.org/uniprot/P68399", "type": "external" } ], "mass": 45144.0, "length": 391, "protein_name": "Casein kinase II subunit alpha", "gene_name": "CSNK2A1", "organism": "Bovine", "refseq_name": "casein kinase II subunit alpha", "refseq_ac": [ { "id": "NP_777060", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777060", "type": "external" } ], "gene_names_uniprotkb": "CSNK2A1; CK2A1", "gene_names_refseq": "CSNK2A1", "protein_names_uniprotkb": "Casein kinase II subunit alpha; 2.7.11.1; CK II alpha", "protein_names_refseq": "CK II alpha; casein kinase 2, alpha 1 polypeptide; casein kinase II subunit alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:282419); (R-BTA-1483191); (R-BTA-201688); (R-BTA-2514853); (R-BTA-6804756); (R-BTA-6814122); (R-BTA-8934903); (R-BTA-8939243); (R-BTA-8948751); (R-BTA-9768727); (R-BTA-9929491)", "pathway_count": 11, "publication_count": 4, "publication_id_list": "15557471;2159007;22267120;8467809", "class_list": "", "function": "Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Feb 2014]., [RefSeq]; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Involvement of ubiquitous protein kinase CK2 in angiogenesis. Naturally derived CK2 inhibitors may be useful for treatment of proliferative retinopathies. (Protein kinase CK2), [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P19138;P20426;Q14013;Q2KI05", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity;GO:0019888 protein phosphatase regulator activity;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005956 protein kinase CK2 complex", "go_biological_process": "GO:1905818 regulation of chromosome separation;GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation;GO:0030307 positive regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P68399-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35246-1", "uniprot_id": [ { "id": "SFTPD_BOVIN", "url": "https://www.uniprot.org/uniprot/P35246", "type": "external" } ], "mass": 37405.0, "length": 369, "protein_name": "Pulmonary surfactant-associated protein D", "gene_name": "SFTPD", "organism": "Bovine", "refseq_name": "pulmonary surfactant-associated protein D precursor", "refseq_ac": [ { "id": "NP_851369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851369", "type": "external" } ], "gene_names_uniprotkb": "SFTPD; SFTP4", "gene_names_refseq": "COLEC7; SFTPD; SP-D", "protein_names_uniprotkb": "Pulmonary surfactant-associated protein D; Lung surfactant protein D; PSP-D; SP-D", "protein_names_refseq": "PSP-D; lung surfactant protein D; pulmonary surfactant-associated protein D precursor; pulmonary surfactant-associated protein D; surfactant, pulmonary-associated protein D", "tax_id": 9913, "disease": "", "pathway": " (bta:282072); (R-BTA-166016); (R-BTA-391160); (R-BTA-5683826); (R-BTA-5686938)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "15163533;20526045;8436402", "class_list": "", "function": "Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties., [UniProtKB]; Elevation of SP-D is found in bronchoalveolar lavage fluid from inoculated lobes of calves infected with bovine adenovirus type 3., [RefSeq, PubMed]; The bSP-D gene has 9 exons spanning about 10.5 kb on chromosome 28 at position q1.8. The 5'-upstream sequence has cis-regulatory elements. It has 2 polymorphisms in the carbohydrate recognition domain (242 Glu/Val & 268 Ala/Gly)., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q863A1", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005771 multivesicular body", "go_biological_process": "GO:0043129 surfactant homeostasis;GO:0045087 innate immune response;GO:0048286 lung alveolus development;GO:0007585 respiratory gaseous exchange by respiratory system;GO:0050766 positive regulation of phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P35246-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61286-1", "uniprot_id": [ { "id": "PABP1_BOVIN", "url": "https://www.uniprot.org/uniprot/P61286", "type": "external" } ], "mass": 70671.0, "length": 636, "protein_name": "Polyadenylate-binding protein 1", "gene_name": "PABPC1", "organism": "Bovine", "refseq_name": "polyadenylate-binding protein 1", "refseq_ac": [ { "id": "NP_776993", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776993", "type": "external" } ], "gene_names_uniprotkb": "PABPC1; PABP1", "gene_names_refseq": "PABP-1; PABPC1", "protein_names_uniprotkb": "Polyadenylate-binding protein 1; PABP-1; Poly(A)-binding protein 1", "protein_names_refseq": "poly(A)-binding protein 1; polyadenylate-binding protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:282296); (R-BTA-156827); (R-BTA-429947); (R-BTA-450408); (R-BTA-72649); (R-BTA-975956); (R-BTA-975957)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability., [UniProtKB, UniProtKB]; Binds the poly(A) tail of mRNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3T0J7", "ec_number_list": [], "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding;GO:0008266 poly(U) RNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030027 lamellipodium;GO:0031252 cell leading edge", "go_biological_process": "GO:0070934 CRD-mediated mRNA stabilization;GO:2000767 positive regulation of cytoplasmic translation;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P61286-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27674-1", "uniprot_id": [ { "id": "GTR1_BOVIN", "url": "https://www.uniprot.org/uniprot/P27674", "type": "external" } ], "mass": 54132.0, "length": 492, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 1", "gene_name": "SLC2A1", "organism": "Bovine", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 1", "refseq_ac": [ { "id": "NP_777027", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777027", "type": "external" } ], "gene_names_uniprotkb": "SLC2A1; GLUT1", "gene_names_refseq": "SLC2A1", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 1; GLUT-1; Glucose transporter type 1, erythrocyte/brain", "protein_names_refseq": "GLUT-1; glucose transporter type 1, erythrocyte/brain; solute carrier family 2 (facilitated glucose transporter), member 1; solute carrier family 2, facilitated glucose transporter member 1", "tax_id": 9913, "disease": "", "pathway": " (bta:282356); (R-BTA-189200); (R-BTA-196836); (R-BTA-422356); (R-BTA-5653890)", "pathway_count": 5, "publication_count": 8, "publication_id_list": "12581864;15955807;16305752;19912773;20861020;21605761;21910135;26723114", "class_list": "", "function": "Distinct domains of the glucose transporter GLUT1 mediate HTLV envelope binding and virus entry, [RefSeq, PubMed]; Distinct regulation by glucose deprivation in chromaffin cells, [RefSeq, PubMed]; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Required for mesendoderm differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Hyperthermia-induced Hsp90.eNOS preserves mitochondrial respiration in hyperglycemic endothelial cells by down-regulating Glut-1 and up-regulating G6PD activity., [RefSeq, PubMed]; Low GLUT1 and GLUT3 expression in nonclassical monocytes was unaltered during differentiation into macrophages. GLUT4 mRNA was only detectable in unstimulated macrophages. Neither monocytes nor macrophages were insulin responsive., [RefSeq, PubMed]; Significant increases in GLUT1 gene expression were observed during early lactation., [RefSeq, PubMed]; The different conformations of the GLUT-1 transporter in luminal (blood facing) and abluminal (brain facing) membranes of bovine cerebral endothelial cells arise from differential phosphorylation of GLUT-1, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A1L519;Q0VCX8", "ec_number_list": [], "go_molecular_function": "GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0042802 identical protein binding;GO:0055056 D-glucose transmembrane transporter activity;GO:0015150 fucose transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0045494 photoreceptor cell maintenance;GO:0032868 response to insulin;GO:0015911 long-chain fatty acid import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P27674-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18203-1", "uniprot_id": [ { "id": "FKB1A_BOVIN", "url": "https://www.uniprot.org/uniprot/P18203", "type": "external" } ], "mass": 11910.0, "length": 108, "protein_name": "Peptidyl-prolyl cis-trans isomerase FKBP1A", "gene_name": "FKBP1A", "organism": "Bovine", "refseq_name": "peptidyl-prolyl cis-trans isomerase FKBP1A", "refseq_ac": [ { "id": "NP_001030533", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030533", "type": "external" } ], "gene_names_uniprotkb": "FKBP1A; FKBP1", "gene_names_refseq": "FKBP1A; FKBP1B", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase FKBP1A; 12 kDa FK506-binding protein; 12 kDa FKBP; 5.2.1.8; Calstabin-1; FK506-binding protein 1A; FKBP-12; FKBP-1A; Immunophilin FKBP12; PPIase FKBP1A; Rotamase", "protein_names_refseq": "12 kDa FK506-binding protein; 12 kDa FKBP; FK506 binding protein 1A, 12kDa; FK506 binding protein 1B, 12.6 kDa; FK506-binding protein 1A; FKBP-12; FKBP-1A; PPIase FKBP1A; calstabin-1; immunophilin FKBP12; peptidyl-prolyl cis-trans isomerase FKBP1A; rotamase", "tax_id": 9913, "disease": "", "pathway": " (bta:614795); (R-BTA-166208); (R-BTA-2025928); (R-BTA-2173789)", "pathway_count": 4, "publication_count": 12, "publication_id_list": "16305752;1701173;1706222;1710319;1710782;1718307;1868545;1915353;2041572;2253615;2477715;7543369", "class_list": "", "function": "Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5E945", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0044325 transmembrane transporter binding;GO:0046332 SMAD binding;GO:0048185 activin binding;GO:0019855 calcium channel inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0030018 Z disc", "go_biological_process": "GO:0051280 negative regulation of release of sequestered calcium ion into cytosol;GO:0006936 muscle contraction;GO:0032092 positive regulation of protein binding;GO:1990000 amyloid fibril formation;GO:0001933 negative regulation of protein phosphorylation", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P18203-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48734-1", "uniprot_id": [ { "id": "CDK1_BOVIN", "url": "https://www.uniprot.org/uniprot/P48734", "type": "external" } ], "mass": 34025.0, "length": 297, "protein_name": "Cyclin-dependent kinase 1", "gene_name": "CDK1", "organism": "Bovine", "refseq_name": "cyclin-dependent kinase 1", "refseq_ac": [ { "id": "NP_776441", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776441", "type": "external" } ], "gene_names_uniprotkb": "CDK1; CDC2; CDKN1", "gene_names_refseq": "CDC2; CDK1", "protein_names_uniprotkb": "Cyclin-dependent kinase 1; 2.7.11.22; 2.7.11.23; CDK1; Cell division control protein 2 homolog; Cell division protein kinase 1; p34 protein kinase", "protein_names_refseq": "cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; cell division protein kinase 1; cyclin-dependent kinase 1; p34 protein kinase", "tax_id": 9913, "disease": "", "pathway": " (bta:281061); (R-BTA-110056); (R-BTA-174048); (R-BTA-174184); (R-BTA-176408); (R-BTA-176412); (R-BTA-176417); (R-BTA-2299718); (R-BTA-2500257); (R-BTA-2565942); (R-BTA-2980767); (R-BTA-2995383); (R-BTA-3301854); (R-BTA-380259); (R-BTA-380270); (R-BTA-380284); (R-BTA-380320); (R-BTA-4419969); (R-BTA-5620912); (R-BTA-5687128); (R-BTA-5689896); (R-BTA-6804114); (R-BTA-6804757); (R-BTA-68875); (R-BTA-69273); (R-BTA-69478); (R-BTA-75035); (R-BTA-8854518); (R-BTA-8878166); (R-BTA-9833482)", "pathway_count": 30, "publication_count": 3, "publication_id_list": "19724912;8163203;8621400", "class_list": "", "function": "Oligosaccharides of hyaluronan induce angiogenesis through distinct CD44 and RHAMM-mediated signalling pathways involving Cdc2 and gamma-adducin., [RefSeq, PubMed]; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition via association with multiple interphase cyclins (By similarity). Phosphorylates PARVA/actopaxin, APC, AMPH, APC, ASB7, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, UHRF1, KAT5, LMNA, LMNB, LBR, MKI67, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MLST8, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RBBP8/CtIP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2, CGAS, GLI2, ZAR1 and RUNX2 (By similarity). CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs (By similarity). Essential for early stages of embryonic development (By similarity). During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation (By similarity). Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis (By similarity). Phosphorylates KRT5 during prometaphase and metaphase (By similarity). Activated by the CDK-activating kinase (CAK) complex consisting of CDK7, cyclin-H/CCNH and MAT1, which is a master regulator of CDK activity (By similarity). Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair (By similarity). Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression (By similarity). Catalyzes lamin (LMNA, LMNB1 and LMNB2) phosphorylation at the onset of mitosis, promoting nuclear envelope breakdown (By similarity). In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons (By similarity). The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis (By similarity). NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (By similarity). In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis (By similarity). The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis (By similarity). In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis (By similarity). This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes (By similarity). EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (By similarity). CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity). CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (By similarity). Regulates the amplitude of the cyclic expression of the core clock gene BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (By similarity). Phosphorylates EML3 at 'Thr-881' which is essential for its interaction with HAUS augmin-like complex and TUBG1 (By similarity). Phosphorylates CGAS during mitosis, leading to its inhibition, thereby preventing CGAS activation by self DNA during mitosis (By similarity). Phosphorylates SKA3 during mitosis which promotes SKA3 binding to the NDC80 complex and anchoring of the SKA complex to kinetochores, to enable stable attachment of mitotic spindle microtubules to kinetochores (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays a key role in the control of the eukaryotic cell cycle. Required for entry into S-phase and mitosis. Acts as a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. May function in concert with npp-16 to arrest prophase blastomeres in response to anoxia., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2YDM6", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "1.14.11.65", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65", "type": "external" }, { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0030496 midbody;GO:0005876 spindle microtubule", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0006915 apoptotic process;GO:0042752 regulation of circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P48734-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21758-1", "uniprot_id": [ { "id": "MSRE_BOVIN", "url": "https://www.uniprot.org/uniprot/P21758", "type": "external" } ], "mass": 50057.0, "length": 453, "protein_name": "Macrophage scavenger receptor types I and II", "gene_name": "MSR1", "organism": "Bovine", "refseq_name": "macrophage scavenger receptor types I and II isoform 1", "refseq_ac": [ { "id": "NP_001106711", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106711", "type": "external" } ], "gene_names_uniprotkb": "MSR1", "gene_names_refseq": "MSR1", "protein_names_uniprotkb": "Macrophage scavenger receptor types I and II; Macrophage acetylated LDL receptor I and II", "protein_names_refseq": "macrophage acetylated LDL receptor I and II; macrophage scavenger receptor types I and II isoform 1; macrophage scavenger receptor types I and II", "tax_id": 9913, "disease": "", "pathway": " (bta:281311)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2300204;2300208", "class_list": "", "function": "Membrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands. Recognizes and internalizes modified forms of low-density lipoproteins including acetylated LDL (AcLDL) and oxidized LDL (OxLDL), thereby promoting cholesterol uptake and contributing to foam cell formation during atherogenesis. Binds various pathogen-associated and damage-associated molecules, including bacterial cell wall components, apoptotic cell debris and polyanionic ligands, supporting macrophage clearance activity in innate immune defense. Upon stimulation by CpG DNA, mediates activation of LYN, which phosphorylates SYK that is subsequently recruited to endosomal TLR9 to promote downstream TLR9 signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A5PJV2", "ec_number_list": [], "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0031072 heat shock protein binding;GO:0051879 Hsp90 protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034362 low-density lipoprotein particle;GO:0016020 membrane", "go_biological_process": "GO:0006898 receptor-mediated endocytosis;GO:0070207 protein homotrimerization;GO:0006911 phagocytosis, engulfment;GO:0010629 negative regulation of gene expression;GO:0010744 positive regulation of macrophage derived foam cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P21758-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63171-1", "uniprot_id": [ { "id": "DYLT1_BOVIN", "url": "https://www.uniprot.org/uniprot/P63171", "type": "external" } ], "mass": 12452.0, "length": 113, "protein_name": "Dynein light chain Tctex-type 1", "gene_name": "DYNLT1", "organism": "Bovine", "refseq_name": "dynein light chain Tctex-type 1", "refseq_ac": [ { "id": "NP_777045", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777045", "type": "external" } ], "gene_names_uniprotkb": "DYNLT1; TCTEL; TCTEX-1; TCTEX1", "gene_names_refseq": "DYNLT1; TCTEL1", "protein_names_uniprotkb": "Dynein light chain Tctex-type 1; T-complex testis-specific protein 1 homolog", "protein_names_refseq": "T-complex testis-specific protein 1 homolog; dynein light chain Tctex-type 1; t-complex-associated-testis-expressed 1-like 1", "tax_id": 9913, "disease": "", "pathway": " (bta:282380)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11425878;11967380;16956385;9677391", "class_list": "", "function": "Component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Required for structural and functional integrity of cilia (By similarity). Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia., [UniProtKB, UniProtKB]; Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation. Unrelated to the role in retrograde microtubule-associated movement may play a role in the dimerization of cytoplasmic proteins/domains such as for ACVR2B. Binds to the cytoplasmic domain of ACVR2B and, in vitro, inhibits ACVR2B signaling (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q15763;Q32PD4", "ec_number_list": [], "go_molecular_function": "GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005819 spindle;GO:0005874 microtubule;GO:0005868 cytoplasmic dynein complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007399 nervous system development;GO:0051301 cell division;GO:0007018 microtubule-based movement;GO:0043001 Golgi to plasma membrane protein transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P63171-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P57709-1", "uniprot_id": [ { "id": "AT2C1_BOVIN", "url": "https://www.uniprot.org/uniprot/P57709", "type": "external" } ], "mass": 104780.0, "length": 953, "protein_name": "Calcium-transporting ATPase type 2C member 1", "gene_name": "ATP2C1", "organism": "Bovine", "refseq_name": "calcium-transporting ATPase type 2C member 1", "refseq_ac": [ { "id": "NP_786979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786979", "type": "external" } ], "gene_names_uniprotkb": "ATP2C1; SPCA", "gene_names_refseq": "ATP2C1; SPCA1; SPCA", "protein_names_uniprotkb": "Calcium-transporting ATPase type 2C member 1; 7.2.2.10; ATP-dependent Ca(2+) pump PMR1; ATPase 2C1; Ca(2+)/Mn(2+)-ATPase 2C1; SPCA1; Secretory pathway Ca(2+)-transporting ATPase type 1", "protein_names_refseq": "ATP-dependent Ca(2+) pump PMR1; ATPase 2C1; ATPase, Ca++ transporting, type 2C, member 1; Ca(2+)/Mn(2+)-ATPase 2C1; calcium-transporting ATPase type 2C member 1; secretory pathway Ca(2+)-transporting ATPase type 1; secretory pathway Ca(2+)-transporting ATPase", "tax_id": 9913, "disease": "", "pathway": " (bta:327663); (R-BTA-936837)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (By similarity). Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (By similarity). Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology. Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity (By similarity). Participates in Ca(2+) and Mn(2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity (By similarity). May also play a role in the maintenance of Ca(2+) and Mn(2+) homeostasis and signaling in the cytosol while preventing cytotoxicity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Catalyzes the hydrolysis of ATP coupled with the transport of calcium., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0030145 manganese ion binding;GO:0016887 ATP hydrolysis activity;GO:0005509 calcium ion binding;GO:0005388 P-type calcium transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0008544 epidermis development;GO:0030036 actin cytoskeleton organization;GO:0042998 positive regulation of Golgi to plasma membrane protein transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P57709-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61625-1", "uniprot_id": [ { "id": "ITAL_BOVIN", "url": "https://www.uniprot.org/uniprot/P61625", "type": "external" } ], "mass": 128726.0, "length": 1165, "protein_name": "Integrin alpha-L", "gene_name": "ITGAL", "organism": "Bovine", "refseq_name": "integrin alpha-L precursor", "refseq_ac": [ { "id": "NP_937864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_937864", "type": "external" } ], "gene_names_uniprotkb": "ITGAL", "gene_names_refseq": "ITGAL", "protein_names_uniprotkb": "Integrin alpha-L; CD11 antigen-like family member A; LFA-1A; Leukocyte adhesion glycoprotein LFA-1 alpha chain; Leukocyte function-associated molecule 1 alpha chain", "protein_names_refseq": "CD11 antigen-like family member A; LFA-1A; alpha polypeptide); antigen CD11A; integrin alpha-L precursor; integrin alpha-L; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; leukocyte adhesion glycoprotein LFA-1 alpha chain; leukocyte function-associated molecule 1 alpha chain; lymphocyte function-associated antigen 1, alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:281874); (R-BTA-198933); (R-BTA-202733); (R-BTA-216083); (R-BTA-6798695)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "14697514;15925274", "class_list": "", "function": "Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4 (By similarity). Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Acts as a platform at the immunological synapse to translate TCR engagement and density of the ITGAL ligand ICAM1 into graded adhesion (By similarity). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (By similarity). Integrins ITGAL:ITGB2 functions as a receptor of the neuron-specific adhesion molecule ICAM5 ensuring neuron cell-leukocyte adhesion. Integrin ITGAL/ITGB2 that functions as a signaling receptor of ICAM2, ensuring leukocyte cell-cell adhesion on resting cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 12, "predicted_n_glycosites": 11, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "Q6TYB8", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030369 ICAM-3 receptor activity;GO:0038023 signaling receptor activity;GO:0004895 cell adhesion receptor activity", "go_cellular_component": "GO:0009986 cell surface;GO:0045121 membrane raft;GO:0034687 integrin alphaL-beta2 complex;GO:0008305 integrin complex", "go_biological_process": "GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0007229 integrin-mediated signaling pathway;GO:0006909 phagocytosis;GO:0007160 cell-matrix adhesion;GO:0033631 cell-cell adhesion mediated by integrin", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P61625-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41541-1", "uniprot_id": [ { "id": "USO1_BOVIN", "url": "https://www.uniprot.org/uniprot/P41541", "type": "external" } ], "mass": 107515.0, "length": 961, "protein_name": "General vesicular transport factor p115", "gene_name": "USO1", "organism": "Bovine", "refseq_name": "general vesicular transport factor p115", "refseq_ac": [ { "id": "NP_777270", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777270", "type": "external" } ], "gene_names_uniprotkb": "USO1; VDP", "gene_names_refseq": "USO1; VDP", "protein_names_uniprotkb": "General vesicular transport factor p115; Protein USO1 homolog; TAP; Transcytosis-associated protein; Vesicle-docking protein", "protein_names_refseq": "TAP; USO1 homolog, vesicle docking protein; USO1 vesicle docking protein homolog; general vesicular transport factor p115; membrane tethering protein p115; protein USO1 homolog; transcytosis-associated protein; vesicle docking protein p115; vesicle-docking protein; vesicular transport factor p115", "tax_id": 9913, "disease": "", "pathway": " (bta:317724); (R-BTA-204005); (R-BTA-6807878)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "1512287;19414022;7831323", "class_list": "", "function": "General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The p115 structures show a novel alpha-solenoid architecture constructed of 12 armadillo-like, tether-repeat, alpha-helical tripod motifs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32PH6", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0012507 ER to Golgi transport vesicle membrane;GO:0005795 Golgi stack", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0051260 protein homooligomerization;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0061025 membrane fusion;GO:0045056 transcytosis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P41541-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07107-1", "uniprot_id": [ { "id": "ACBP_BOVIN", "url": "https://www.uniprot.org/uniprot/P07107", "type": "external" } ], "mass": 10044.0, "length": 87, "protein_name": "Acyl-CoA-binding protein", "gene_name": "DBI", "organism": "Bovine", "refseq_name": "acyl-CoA-binding protein", "refseq_ac": [ { "id": "NP_001106792", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106792", "type": "external" } ], "gene_names_uniprotkb": "DBI", "gene_names_refseq": "ACBP; DBI; EP", "protein_names_uniprotkb": "Acyl-CoA-binding protein; ACBP; DBI; Diazepam-binding inhibitor; EP; Endozepine", "protein_names_refseq": "acyl-CoA-binding protein; diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein); diazepam-binding inhibitor; endozepine", "tax_id": 9913, "disease": "", "pathway": " (bta:768330); (R-BTA-77289)", "pathway_count": 2, "publication_count": 14, "publication_id_list": "11491287;1518047;1622397;16641108;17953517;1931985;22747188;25824585;28782558;2881742;3525533;3663196;8358232;8503960", "class_list": "", "function": "Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor., [UniProtKB, PubMed]; Results describe the folding kinetics of bovine acyl-CoA binding protein as measured by 15N relaxation dispersion measurements under equilibrium conditions., [RefSeq, PubMed]; Role for an intermediate in a conserved eukaryotic binding protein, [RefSeq, PubMed]; The denatured state of ACBP at near-zero denaturant is unusually compact and enriched in long-range structure that can be perturbed by discrete hydrophobic core mutations., [RefSeq, PubMed]; This study finds that the compaction of the denatured state is related to changing temperature as the different variants of acyl-coenzyme A binding protein have similar m-values when they are at the same temperature but different urea concentration. These results have important implications for protein folding and stability under different environmental conditions., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29RG9", "ec_number_list": [], "go_molecular_function": "GO:0000062 fatty-acyl-CoA binding;GO:0042802 identical protein binding;GO:0036042 long-chain fatty acyl-CoA binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0032994 protein-lipid complex", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0036151 phosphatidylcholine acyl-chain remodeling;GO:2001140 positive regulation of phospholipid transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P07107-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17697-1", "uniprot_id": [ { "id": "CLUS_BOVIN", "url": "https://www.uniprot.org/uniprot/P17697", "type": "external" } ], "mass": 51114.0, "length": 439, "protein_name": "Clusterin", "gene_name": "CLU", "organism": "Bovine", "refseq_name": "clusterin preproprotein", "refseq_ac": [ { "id": "NP_776327", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776327", "type": "external" } ], "gene_names_uniprotkb": "CLU", "gene_names_refseq": "CLU; gpIII", "protein_names_uniprotkb": "Clusterin; Glycoprotein III; GpIII", "protein_names_refseq": "clusterin preproprotein; glycoprotein III", "tax_id": 9913, "disease": "", "pathway": " (bta:280750); (R-BTA-114608); (R-BTA-166665); (R-BTA-6803157); (R-BTA-977606)", "pathway_count": 5, "publication_count": 6, "publication_id_list": "11801660;16305752;1691174;21667239;25845404;26495903", "class_list": "", "function": "Clusterin haplotype AA may be a genetic marker on mastitis and other performance for Chinese Holstein cows., [RefSeq, PubMed]; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement: inhibits assembly of the complement membrane attack complex (MAC) by preventing polymerization of C9 pore component of the MAC complex. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity (By similarity). Following stress, promotes apoptosis (By similarity). Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation. An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5. Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (By similarity). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The expression of CLU gene was significantly higher among motility-impaired crossbred bull semen compared to the good quality one., [RefSeq, PubMed]; This gene encodes a protein that is similar to the human clusterin protein, a secreted chaperone that can also be found in the cell cytosol under certain stress conditions. The human protein has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders.[provided by RefSeq, May 2011]., [RefSeq]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "A5D983;Q148K1", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0051787 misfolded protein binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0002434 immune complex clearance;GO:0042127 regulation of cell population proliferation;GO:0043065 positive regulation of apoptotic process;GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage;GO:0050821 protein stabilization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P17697-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21856-1", "uniprot_id": [ { "id": "GDIA_BOVIN", "url": "https://www.uniprot.org/uniprot/P21856", "type": "external" } ], "mass": 50566.0, "length": 447, "protein_name": "Rab GDP dissociation inhibitor alpha", "gene_name": "GDI1", "organism": "Bovine", "refseq_name": "rab GDP dissociation inhibitor alpha", "refseq_ac": [ { "id": "NP_776489", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776489", "type": "external" } ], "gene_names_uniprotkb": "GDI1; RABGDIA", "gene_names_refseq": "GDI1", "protein_names_uniprotkb": "Rab GDP dissociation inhibitor alpha; GDI-1; Guanosine diphosphate dissociation inhibitor 1; Rab GDI alpha; SMG p25A GDI", "protein_names_refseq": "GDI-1; SMG p25A GDI; guanosine diphosphate dissociation inhibitor 1; rab GDI alpha; rab GDP dissociation inhibitor alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:281188); (R-BTA-8876198)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "11208110;12623022;1904992;2115118;8609986", "class_list": "", "function": "Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP., [UniProtKB, UniProtKB, UniProtKB]; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4FUY4", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005093 Rab GDP-dissociation inhibitor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0015031 protein transport;GO:0016192 vesicle-mediated transport;GO:0050771 negative regulation of axonogenesis;GO:0032482 Rab protein signal transduction;GO:0090315 negative regulation of protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P21856-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46411-1", "uniprot_id": [ { "id": "EAA1_BOVIN", "url": "https://www.uniprot.org/uniprot/P46411", "type": "external" } ], "mass": 59591.0, "length": 542, "protein_name": "Excitatory amino acid transporter 1", "gene_name": "SLC1A3", "organism": "Bovine", "refseq_name": "excitatory amino acid transporter 1", "refseq_ac": [ { "id": "NP_777025", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777025", "type": "external" } ], "gene_names_uniprotkb": "SLC1A3; EAAT1; GLAST1; GLAST", "gene_names_refseq": "SLC1A3", "protein_names_uniprotkb": "Excitatory amino acid transporter 1; GLAST-1; Sodium-dependent glutamate/aspartate transporter 1; Solute carrier family 1 member 3", "protein_names_refseq": "GLAST-1; excitatory amino acid transporter 1; sodium-dependent glutamate/aspartate transporter 1; solute carrier family 1 (glial high affinity glutamate transporter), member 3", "tax_id": 9913, "disease": "", "pathway": " (bta:282354); (R-BTA-210455); (R-BTA-210500); (R-BTA-9958863)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "7723632", "class_list": "", "function": "Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7723632). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VCK3", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0005314 high-affinity L-glutamate transmembrane transporter activity;GO:0015501 glutamate:sodium symporter activity;GO:0016595 glutamate binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043025 neuronal cell body;GO:0045202 synapse;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1902476 chloride transmembrane transport;GO:0043200 response to amino acid;GO:0070633 transepithelial transport;GO:0070779 D-aspartate import across plasma membrane;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P46411-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P67939-1", "uniprot_id": [ { "id": "P53_BOVIN", "url": "https://www.uniprot.org/uniprot/P67939", "type": "external" } ], "mass": 43256.0, "length": 386, "protein_name": "Cellular tumor antigen p53", "gene_name": "TP53", "organism": "Bovine", "refseq_name": "cellular tumor antigen p53", "refseq_ac": [ { "id": "NP_776626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776626", "type": "external" } ], "gene_names_uniprotkb": "TP53", "gene_names_refseq": "TP53", "protein_names_uniprotkb": "Cellular tumor antigen p53; Tumor suppressor p53", "protein_names_refseq": "cellular tumor antigen p53; p53 tumor suppressor phosphoprotein; tumor protein 53; tumor protein p53 (Li-Fraumeni syndrome); tumor suppressor p53", "tax_id": 9913, "disease": "", "pathway": " (bta:281542); (R-BTA-2559580); (R-BTA-2559586); (R-BTA-349425); (R-BTA-5689880); (R-BTA-5689896); (R-BTA-5693565); (R-BTA-6804754); (R-BTA-6804756); (R-BTA-6804757); (R-BTA-6804758); (R-BTA-6804759); (R-BTA-6804760); (R-BTA-6811555); (R-BTA-69473); (R-BTA-69481); (R-BTA-69541); (R-BTA-69895); (R-BTA-8852276); (R-BTA-8941855); (R-BTA-9833482)", "pathway_count": 21, "publication_count": 8, "publication_id_list": "14588144;15064348;25653076;25753134;30132847;30420201;7626789;8807776", "class_list": "", "function": "Bov-A2 insertion into the TP53 promoter in Antilopinae and Tragelaphini may not only provide a genetic network that regulates mammary involution, but can also answer the need for rapid mammary involution in Savanna antelopes Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-BMAL1-mediated transcriptional activation of PER2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Our study proved that the expression of Hsp27/P53 differed across the testis developmental stages and the expression of P53 was higher in the testis of cattle-yak, which suggested that the infertility of cattle-yak may be caused by the upregulation of P53., [RefSeq, PubMed]; PI3K/Akt and p53 are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide, [RefSeq, PubMed]; Results demonstrate that embryonic developmental potential is related to the time of first cleavage and that p66(shc), but not p53, is up-regulated in early arrested in vitro-produced bovine embryos., [RefSeq, PubMed]; The HSP90 inhibitor 17-DMAG, counteracted the LPS - induced effects both in vivo and in vitro. Specifically, this hsp90 inhibitor reduced phosphorylated P53 levels and lessened the activation of myosin light chain 2 (phosphorylation), [RefSeq, PubMed]; The effect of p53 expression on the development of cloned embryos, and its interaction with HDAC1 and DNMT3A are reported., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q29628;Q3ZCF1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0005507 copper ion binding;GO:0036310 ATP-dependent DNA/DNA annealing activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0043065 positive regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051262 protein tetramerization;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P67939-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61223-1", "uniprot_id": [ { "id": "RAP1B_BOVIN", "url": "https://www.uniprot.org/uniprot/P61223", "type": "external" } ], "mass": 20825.0, "length": 184, "protein_name": "Ras-related protein Rap-1b", "gene_name": "RAP1B", "organism": "Bovine", "refseq_name": "ras-related protein Rap-1b", "refseq_ac": [ { "id": "NP_787018", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787018", "type": "external" } ], "gene_names_uniprotkb": "RAP1B", "gene_names_refseq": "RAP1B", "protein_names_uniprotkb": "Ras-related protein Rap-1b; 3.6.5.2; GTP-binding protein smg p21B", "protein_names_refseq": "GTP-binding protein smg p21B; ras-related protein Rap-1b", "tax_id": 9913, "disease": "", "pathway": " (bta:327708); (R-BTA-354192); (R-BTA-354194); (R-BTA-372708); (R-BTA-392517); (R-BTA-5674135); (R-BTA-6798695); (R-BTA-8875555)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "2105724", "class_list": "", "function": "GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P09526;Q3T0M4", "ec_number_list": [ { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0016020 membrane", "go_biological_process": "GO:2000301 negative regulation of synaptic vesicle exocytosis;GO:0061028 establishment of endothelial barrier;GO:0032486 Rap protein signal transduction;GO:0071320 cellular response to cAMP;GO:1901888 regulation of cell junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P61223-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38574-1", "uniprot_id": [ { "id": "UPK3A_BOVIN", "url": "https://www.uniprot.org/uniprot/P38574", "type": "external" } ], "mass": 30757.0, "length": 287, "protein_name": "Uroplakin-3a", "gene_name": "UPK3A", "organism": "Bovine", "refseq_name": "uroplakin-3a precursor", "refseq_ac": [ { "id": "NP_777134", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777134", "type": "external" } ], "gene_names_uniprotkb": "UPK3A; UPK3", "gene_names_refseq": "UP3a; UPIII; UPK3A; Upk3", "protein_names_uniprotkb": "Uroplakin-3a; UP3a; UPIII; Uroplakin III", "protein_names_refseq": "uroplakin 3; uroplakin IIIA; uroplakin-3a precursor; uroplakin-3a", "tax_id": 9913, "disease": "", "pathway": " (bta:100336102)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12475947;8270634", "class_list": "", "function": "Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0120001 apical plasma membrane urothelial plaque;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0006833 water transport;GO:0015840 urea transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P38574-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08220-1", "uniprot_id": [ { "id": "GBRB1_BOVIN", "url": "https://www.uniprot.org/uniprot/P08220", "type": "external" } ], "mass": 54130.0, "length": 474, "protein_name": "Gamma-aminobutyric acid receptor subunit beta-1", "gene_name": "GABRB1", "organism": "Bovine", "refseq_name": "gamma-aminobutyric acid receptor subunit beta-1 isoform 1 precursor", "refseq_ac": [ { "id": "NP_776969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776969", "type": "external" } ], "gene_names_uniprotkb": "GABRB1", "gene_names_refseq": "GABRB1", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit beta-1; GABA(A) receptor subunit beta-1; GABAAR subunit beta-1", "protein_names_refseq": "GABA(A) receptor subunit beta-1; GABAAR subunit beta-1; gamma-aminobutyric acid (GABA) A receptor, beta 1; gamma-aminobutyric acid receptor subunit beta-1 isoform 1 precursor; gamma-aminobutyric acid receptor subunit beta-1; gamma-aminobutyric acid type A receptor beta1 subunit; gamma-aminobutyric-acid receptor beta 1-like", "tax_id": 9913, "disease": "", "pathway": " (bta:282239); (R-BTA-977443)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "3037384", "class_list": "", "function": "Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:3037384). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:3037384). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (PubMed:3037384). Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential;GO:0150047 G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane;GO:0034707 chloride channel complex;GO:1902711 GABA-A receptor complex", "go_biological_process": "GO:0006811 monoatomic ion transport;GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0071420 cellular response to histamine;GO:0051932 synaptic transmission, GABAergic", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P08220-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21214-1", "uniprot_id": [ { "id": "TGFB2_BOVIN", "url": "https://www.uniprot.org/uniprot/P21214", "type": "external" } ], "mass": 47692.0, "length": 414, "protein_name": "Transforming growth factor beta-2 proprotein", "gene_name": "TGFB2", "organism": "Bovine", "refseq_name": "transforming growth factor beta-2 proprotein precursor", "refseq_ac": [ { "id": "NP_001106723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106723", "type": "external" } ], "gene_names_uniprotkb": "TGFB2", "gene_names_refseq": "MGF; TGFB2", "protein_names_uniprotkb": "Transforming growth factor beta-2 proprotein; MGF; Milk growth factor", "protein_names_refseq": "TGF-beta-2; milk growth factor; transforming growth factor beta-2 proprotein precursor; transforming growth factor beta-2 proprotein", "tax_id": 9913, "disease": "", "pathway": " (bta:534069); (R-BTA-114608); (R-BTA-2129379); (R-BTA-2173789); (R-BTA-9839389)", "pathway_count": 5, "publication_count": 5, "publication_id_list": "1733936;1799413;2026157;21411746;3469199", "class_list": "", "function": "Data show that TGF-beta pathways operate during ovarian fetal development, and fibrillin 3 is highly expressed at a critical stage early in developing human and bovine fetal ovaries., [RefSeq, PubMed]; Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus (By similarity). Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Multifunctional protein that regulates various processes such as angiogenesis and heart development. Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus. Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal., [UniProtKB, UniProtKB, UniProtKB]; Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034714 type III transforming growth factor beta receptor binding;GO:0005102 signaling receptor binding;GO:0042803 protein homodimerization activity;GO:0001540 amyloid-beta binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005768 endosome;GO:0030424 axon", "go_biological_process": "GO:0051891 positive regulation of cardioblast differentiation;GO:0007165 signal transduction;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P21214-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55270-1", "uniprot_id": [ { "id": "SCNNA_BOVIN", "url": "https://www.uniprot.org/uniprot/P55270", "type": "external" } ], "mass": 73793.0, "length": 650, "protein_name": "Epithelial sodium channel subunit alpha", "gene_name": "SCNN1A", "organism": "Bovine", "refseq_name": "epithelial sodium channel subunit alpha", "refseq_ac": [ { "id": "NP_777023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777023", "type": "external" } ], "gene_names_uniprotkb": "SCNN1A", "gene_names_refseq": "SCNN1A", "protein_names_uniprotkb": "Epithelial sodium channel subunit alpha; Alpha-ENaC; Alpha-NaCH; Amiloride-sensitive sodium channel subunit alpha; Epithelial Na(+) channel subunit alpha; Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA", "protein_names_refseq": "SCNEA; alpha-ENaC; alpha-NaCH; amiloride-sensitive sodium channel subunit alpha; epithelial Na(+) channel subunit alpha; epithelial sodium channel subunit alpha; nonvoltage-gated sodium channel 1 subunit alpha; sodium channel epithelial 1 alpha subunit; sodium channel, non-voltage-gated 1 alpha subunit; sodium channel, nonvoltage-gated 1 alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:282348); (R-BTA-2672351); (R-BTA-9730628)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "22207244;7573394", "class_list": "", "function": "This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis. ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically. It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys. Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O02851", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0050699 WW domain binding;GO:0015280 ligand-gated sodium channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031514 motile cilium;GO:0070062 extracellular exosome", "go_biological_process": "GO:0006883 intracellular sodium ion homeostasis;GO:0035725 sodium ion transmembrane transport;GO:0055078 sodium ion homeostasis;GO:0050891 multicellular organismal-level water homeostasis;GO:0071468 cellular response to acidic pH", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P55270-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32876-1", "uniprot_id": [ { "id": "AT5G1_BOVIN", "url": "https://www.uniprot.org/uniprot/P32876", "type": "external" } ], "mass": 14223.0, "length": 136, "protein_name": "ATP synthase F(0) complex subunit C1, mitochondrial", "gene_name": "ATP5MC1", "organism": "Bovine", "refseq_name": "ATP synthase F(0) complex subunit C1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_788822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788822", "type": "external" } ], "gene_names_uniprotkb": "ATP5MC1; ATP5G1", "gene_names_refseq": "ATP5G1; ATP5MC1", "protein_names_uniprotkb": "ATP synthase F(0) complex subunit C1, mitochondrial; ATP synthase lipid-binding protein; ATP synthase membrane subunit c locus 1; ATP synthase proteolipid P1; ATPase protein 9; ATPase subunit c; Proton-conducting channel, ATP synthase F(0) complex subunit c", "protein_names_refseq": "ATP synthase F(0) complex subunit C1, mitochondrial precursor; ATP synthase F(0) complex subunit C1, mitochondrial; ATP synthase lipid-binding protein, mitochondrial; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9); ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9); ATPase protein 9; ATPase subunit c; mit-ATP synthase proteolipid P1 subunit; proton-conducting channel, ATP synthase F(0) complex subunit c", "tax_id": 9913, "disease": "", "pathway": " (bta:338053); (R-BTA-1268020); (R-BTA-163210); (R-BTA-8949613)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "17570365;1827992;1829867;25851905;2868890", "class_list": "", "function": "Subunit c, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. With the subunit a (MT-ATP6), forms the proton-conducting channel in the F(0) domain, that contains two crucial half-channels (inlet and outlet) that facilitate proton movement from the mitochondrial intermembrane space (IMS) into the matrix. Protons are taken up via the inlet half-channel and released through the outlet half-channel, following a Grotthuss mechanism., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P00839;Q3SZC8", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0015252 proton channel activity;GO:0015078 proton transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0045259 proton-transporting ATP synthase complex;GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P32876-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61602-1", "uniprot_id": [ { "id": "NCALD_BOVIN", "url": "https://www.uniprot.org/uniprot/P61602", "type": "external" } ], "mass": 22245.0, "length": 193, "protein_name": "Neurocalcin-delta", "gene_name": "NCALD", "organism": "Bovine", "refseq_name": "neurocalcin-delta", "refseq_ac": [ { "id": "NP_776823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776823", "type": "external" } ], "gene_names_uniprotkb": "NCALD", "gene_names_refseq": "NCALD", "protein_names_uniprotkb": "Neurocalcin-delta", "protein_names_refseq": "neurocalcin-delta", "tax_id": 9913, "disease": "", "pathway": " (bta:281940); (R-BTA-451308)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "15005606;1599450;16305752;7852401;8387172;8811741;9886296", "class_list": "", "function": "May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions., [UniProtKB, UniProtKB, UniProtKB]; Neurocalcin delta modulates the Ca2+-modulated membrane guanylate cyclase transduction system in the neurons of the retinal inner plexiform layer., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L533;P29554;Q0IIL3;Q9H0W2", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005509 calcium ion binding;GO:0030276 clathrin binding;GO:0015631 tubulin binding", "go_cellular_component": "", "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P61602-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08166-1", "uniprot_id": [ { "id": "KAD2_BOVIN", "url": "https://www.uniprot.org/uniprot/P08166", "type": "external" } ], "mass": 26497.0, "length": 241, "protein_name": "Adenylate kinase 2, mitochondrial", "gene_name": "AK2", "organism": "Bovine", "refseq_name": "adenylate kinase 2, mitochondrial", "refseq_ac": [ { "id": "NP_776314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776314", "type": "external" } ], "gene_names_uniprotkb": "AK2", "gene_names_refseq": "AK2", "protein_names_uniprotkb": "Adenylate kinase 2, mitochondrial; 2.7.4.3; AK 2; ATP-AMP transphosphorylase 2; ATP:AMP phosphotransferase; Adenylate monophosphate kinase", "protein_names_refseq": "AK 2; ATP-AMP transphosphorylase 2; ATP:AMP phosphotransferase; adenylate kinase 2, mitochondrial; adenylate kinase isozyme 2; adenylate monophosphate kinase", "tax_id": 9913, "disease": "", "pathway": " (bta:280716); (R-BTA-499943)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "16305752;2227435;28100784;3002789;3040716;8868479", "class_list": "", "function": "Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P08167;Q2KIJ7", "ec_number_list": [ { "id": "2.7.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" } ], "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0005524 ATP binding;GO:0019205 nucleobase-containing compound kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0006172 ADP biosynthetic process;GO:0046033 AMP metabolic process;GO:0046034 ATP metabolic process;GO:0006139 nucleobase-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P08166-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52175-1", "uniprot_id": [ { "id": "NDKA_BOVIN", "url": "https://www.uniprot.org/uniprot/P52175", "type": "external" } ], "mass": 17298.0, "length": 152, "protein_name": "Nucleoside diphosphate kinase A", "gene_name": "NME1", "organism": "Bovine", "refseq_name": "nucleoside diphosphate kinase A 2 isoform X1", "refseq_ac": [ { "id": "XP_024835463", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024835463", "type": "external" } ], "gene_names_uniprotkb": "NME1", "gene_names_refseq": "NBR-A; NBR-B; NME1-1; NME1", "protein_names_uniprotkb": "Nucleoside diphosphate kinase A; 2.7.11.1; 2.7.13.3; 2.7.4.18; 2.7.4.6; 3.1.11.-; 3.1.24.-; Farnesyl diphosphate kinase NME1; GAAD; Histidine protein kinase NDK; NBR-A; NBR-B; NDK1; NDP kinase A; NDPK A; Non-specific serine/threonine protein kinase NME1; Nucleoside diphoshate kinase 1; Nucleoside diphosphate kinase NBR-A; Nucleoside diphosphate kinase NBR-B; Putative 3'-5'-DNA exonuclease NDK1; Putative granzyme A-activated DNA endonuclease", "protein_names_refseq": "nucleoside diphosphate kinase A 2 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-499943); (R-BTA-9748787); (R-BTA-9755088)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10329774;9760230", "class_list": "", "function": "Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore contributing to the nucleoside triphosphate homeostasis (PubMed:9760230). Also phosphorylates geranyl pyrophosphate (GPP) and farnesyl pyrophosphate (FPP), linking it to isoprenoid metabolism. Additionally, functions as a non-specific serine/threonine kinase and histidine protein kinase, transferring phosphoryl groups from its active site to target proteins. May function as a Mg(2+)-dependent single-stranded DNA endonuclease as part of the SET complex, cooperating with the 3'-5' exonuclease TREX1 to mediate apoptotic DNA fragmentation in cytotoxic T lymphocytes. Reported to nick one DNA strand, enabling TREX1 to remove nucleotides from the free 3' end, enhancing DNA damage and suppressing DNA end reannealing and repair. Has been shown to cleave double strands DNA within the 3'-portions of both 5'-SHS silencer and NHE basal promoter element of the PDGFA gene, potentially repressing its transcription. May also function as a Mg(2+)-dependent 3'-5' DNA exonuclease, excising nucleotides from 3' single-stranded DNA or DNA with 3' single strand overhangs, suggesting a role in DNA nucleolytic processing (By similarity). Involved in the regulation of tumor metastasis and cellular differentiation (By similarity). Also required for cell motility (By similarity). May control, with NME2, AcCoA usage between histone acetylation and fatty acid synthesis, possibly by binding and releasing AcCoA at transcriptionally active chromatin regions in proximity to histone acetyltransferase (HAT) (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P52174", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0120225 coenzyme A binding;GO:0008296 3'-5'-DNA exonuclease activity;GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol;GO:0032587 ruffle membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0042304 regulation of fatty acid biosynthetic process;GO:0050679 positive regulation of epithelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P52175-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31081-1", "uniprot_id": [ { "id": "CH60_BOVIN", "url": "https://www.uniprot.org/uniprot/P31081", "type": "external" } ], "mass": 61108.0, "length": 573, "protein_name": "60 kDa heat shock protein, mitochondrial", "gene_name": "HSPD1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HSPD1; HSP60", "gene_names_refseq": "", "protein_names_uniprotkb": "60 kDa heat shock protein, mitochondrial; 5.6.1.7; 60 kDa chaperonin; CPN60; Chaperonin 60; HSP-60; Heat shock protein 60; Hsp60; Mitochondrial matrix protein P1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8096152", "class_list": "", "function": "Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0051087 protein-folding chaperone binding;GO:0016853 isomerase activity;GO:0140662 ATP-dependent protein folding chaperone", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0032991 protein-containing complex;GO:0005832 chaperonin-containing T-complex", "go_biological_process": "GO:0032727 positive regulation of interferon-alpha production;GO:0045041 protein import into mitochondrial intermembrane space;GO:0009409 response to cold;GO:0032755 positive regulation of interleukin-6 production;GO:0042110 T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P31081-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52176-1", "uniprot_id": [ { "id": "MMP9_BOVIN", "url": "https://www.uniprot.org/uniprot/P52176", "type": "external" } ], "mass": 79088.0, "length": 712, "protein_name": "Matrix metalloproteinase-9", "gene_name": "MMP9", "organism": "Bovine", "refseq_name": "matrix metalloproteinase-9 precursor", "refseq_ac": [ { "id": "NP_777169", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777169", "type": "external" } ], "gene_names_uniprotkb": "MMP9", "gene_names_refseq": "MMP9", "protein_names_uniprotkb": "Matrix metalloproteinase-9; 3.4.24.35; 92 kDa gelatinase; 92 kDa type IV collagenase; GELB; Gelatinase B; MMP-9", "protein_names_refseq": "92 kDa gelatinase; 92 kDa type IV collagenase; GELB; MMP-9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); matrix metalloproteinase 9 (gelatinase B, 92kDa matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); matrix metalloproteinase-9 precursor; matrix metalloproteinase-9", "tax_id": 9913, "disease": "", "pathway": " (bta:282871); (R-BTA-1433557); (R-BTA-1442490); (R-BTA-1474228); (R-BTA-1592389); (R-BTA-3928665); (R-BTA-6798695); (R-BTA-9009391)", "pathway_count": 8, "publication_count": 9, "publication_id_list": "12398942;12586316;12606436;21722622;23891690;25358728;26599598;37643525;7770085", "class_list": "", "function": "Activation of cytosolic MMP-9 and MMP-2 was investigated in the retinal endothelial cells incubated in high glucose for 6-96 h, and correlated with their mitochondrial accumulation and mitochondrial damage., [RefSeq, PubMed]; Cells constitutively produced proMMP-9 and proMMP-2, and treatment with TNFalpha, hepatocyte growth factor, and 12-O-tetradecanoylphorbol 13-acetate resulted in significant increase in level of proMMP-9 but not in level of proMMP-2., [RefSeq, PubMed]; Expression of mRNA and protein during deciduous tooth resorption in odontoclasts, [RefSeq, PubMed]; In diabetic retinopathy transcription of MMP-9 is regulated by AP-1 binding at both, proximal and distal sites of its promoter, and acetylation of c-Jun and c-Fos subunits is important in its regulation., [RefSeq, PubMed]; Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration (By similarity). Could play a role in bone osteoclastic resorption (By similarity). Cleaves KiSS1 at a Gly-|-Leu bond (By similarity). Cleaves NINJ1 to generate the Secreted ninjurin-1 form (By similarity). Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Matrix metalloproteinase- 9 may contribute to collagen structure modification during postmortem aging of beef., [RefSeq, PubMed]; Results suggest a significant role of matrix metalloproteinase-2 and-9 in growth and development of bovine follicle, [RefSeq, PubMed]; Role of TGF-beta1 and TNF-alpha in IL-1beta mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease., [RefSeq, PubMed]; These data demonstrate that serum neutrophil haptoglobin-MMP 9 complexes appear sooner and decline more rapidly than other acute phase proteins. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 3, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "A5PKB8", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.4.24.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.4.24.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.22.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0016477 cell migration;GO:0030198 extracellular matrix organization;GO:1904645 response to amyloid-beta;GO:0051549 positive regulation of keratinocyte migration", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P52176-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49884-1", "uniprot_id": [ { "id": "ESR1_BOVIN", "url": "https://www.uniprot.org/uniprot/P49884", "type": "external" } ], "mass": 66489.0, "length": 596, "protein_name": "Estrogen receptor", "gene_name": "ESR1", "organism": "Bovine", "refseq_name": "estrogen receptor", "refseq_ac": [ { "id": "NP_001001443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001443", "type": "external" } ], "gene_names_uniprotkb": "ESR1; ESR; NR3A1", "gene_names_refseq": "ESR1", "protein_names_uniprotkb": "Estrogen receptor; ER-alpha; ER; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1", "protein_names_refseq": "ER-alpha; ER; estradiol receptor; estrogen receptor alpha; estrogen receptor; nuclear receptor subfamily 3 group A member 1", "tax_id": 9913, "disease": "", "pathway": " (bta:407238); (R-BTA-1251985); (R-BTA-1257604); (R-BTA-383280); (R-BTA-4090294); (R-BTA-5689896); (R-BTA-6811558); (R-BTA-8866910); (R-BTA-8931987); (R-BTA-8939211); (R-BTA-9009391); (R-BTA-9018519); (R-BTA-9841251)", "pathway_count": 13, "publication_count": 9, "publication_id_list": "12711014;15615701;20715834;21397601;25363750;29960859;31936899;7555698;8999954", "class_list": "", "function": "ER may play a role in the rapid effects of resveratrol in EC and some of the atheroprotective effects of resveratrol may be mediated through rapid activation of ER signaling in EC, [RefSeq, PubMed]; ER-alpha is detected predominantly in the soma whereas ER-beta is only present in the nucleus of a few cells in the frontal cortex., [RefSeq, PubMed]; Missing Information from the Estrogen Receptor Puzzle: Where Are They Localized in Bull Reproductive Tissues and Spermatozoa? Publication Status: Online-Only, [RefSeq, PubMed]; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity). Maintains neuronal survival in response to ischemic reperfusion injury when in the presence of circulating estradiol (17-beta-estradiol/E2) (By similarity)., [UniProtKB, UniProtKB]; Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1, [RefSeq, PubMed]; Our results here suggest that there is a negative correlation between bta-miR-222 and ER-alpha expression during follicular development in cow ovaries., [RefSeq, PubMed]; The mRNA expression of ER-alpha and ER-beta in the hypothalamus of developing male and female bovines, is reported., [RefSeq, PubMed]; There are different levels of ERalpha, ERbeta and PR in bovine oviducts at different cycle stages in vivo, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q6QIS5;Q95131", "ec_number_list": [], "go_molecular_function": "GO:0001093 TFIIB-class transcription factor binding;GO:0034056 estrogen response element binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0000785 chromatin", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0010629 negative regulation of gene expression;GO:0045429 positive regulation of nitric oxide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P49884-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19661-1", "uniprot_id": [ { "id": "CTHL3_BOVIN", "url": "https://www.uniprot.org/uniprot/P19661", "type": "external" } ], "mass": 21567.0, "length": 190, "protein_name": "Cathelicidin-3", "gene_name": "CATHL3", "organism": "Bovine", "refseq_name": "cathelicidin-3 precursor", "refseq_ac": [ { "id": "NP_776426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776426", "type": "external" } ], "gene_names_uniprotkb": "CATHL3; BAC7", "gene_names_refseq": "BAC7; CAMP; CATHL3; PR-59; PR59", "protein_names_uniprotkb": "Cathelicidin-3; Bac7; Bactenecin-7; PR-59", "protein_names_refseq": "bactenecin-7; cathelicidin-3 precursor; cathelicidin-3", "tax_id": 9913, "disease": "", "pathway": " (bta:281037)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "2229048;7925973;8706679", "class_list": "", "function": "Exerts, in vitro, a potent antimicrobial activity. Probably due to an impairment of the function of the respiratory chain and of energy-dependent activities in the inner membrane of susceptible microorganisms., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PJ95", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P19661-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79135-1", "uniprot_id": [ { "id": "MX1_BOVIN", "url": "https://www.uniprot.org/uniprot/P79135", "type": "external" } ], "mass": 74805.0, "length": 648, "protein_name": "Interferon-induced GTP-binding protein Mx1", "gene_name": "MX1", "organism": "Bovine", "refseq_name": "interferon-induced GTP-binding protein Mx1", "refseq_ac": [ { "id": "NP_776365", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776365", "type": "external" } ], "gene_names_uniprotkb": "MX1", "gene_names_refseq": "MX1; Mx1-b; Mx1B", "protein_names_uniprotkb": "Interferon-induced GTP-binding protein Mx1; Myxoma resistance protein 1; Myxovirus resistance protein 1", "protein_names_refseq": "GTP-binding protein; interferon-induced GTP-binding protein Mx1; interferon-inducible myxovirus resistance-1 protein; interferon-inducible protein p78; myxoma resistance protein 1; myxovirus (influenza virus) resistance 1, interferon-inducible protein p78; myxovirus resistance protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:280872); (R-BTA-1169408)", "pathway_count": 2, "publication_count": 12, "publication_id_list": "14729264;14994826;16202617;18062906;19203250;19951175;22385204;23384108;24294956;26498202;26982472;9781814", "class_list": "", "function": "A new bovine Mx gene (designated Mx1B) was isolated from the endometrial cDNA library of the early pregnant cow., [RefSeq, PubMed]; Data indicate that the expression profiles of ISG15, MX1, MX2, and OAS1 could be a useful diagnostic biomarker of gestation. Publication Status: Online-Only, [RefSeq, PubMed]; Interferon-induced dynamin-like GTPase with antiviral activity against rabies virus (RABV), vesicular stomatitis virus (VSV) and murine pneumonia virus (MPV). Isoform 1 but not isoform 2 shows antiviral activity against vesicular stomatitis virus (VSV)., [UniProtKB, PubMed, PubMed, PubMed]; MX1-a, MX1B and MX2 are affected by the type I IFN pathway during pregnancy and are involved in an immune response to protect the mother and fetus, [RefSeq, PubMed]; Overexpression of bovine Mx1 protein inhibits the replication of foot-and-mouth disease virus., [RefSeq, PubMed]; The proximal GC boxes were found to be essential for IFN response in the bovine Mx1 promoter with the deletion mutants., [RefSeq, PubMed]; The replication levels of foot-and-mouth disease virus RNA were promoted by silencing bovine Mx1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O46623;Q17QZ1;Q53ZW3;Q867D5", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication;GO:0009615 response to virus;GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane", "synthesized_glycan_count": 0, "hit_score": 1.3, "record_id": "P79135-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31228-1", "uniprot_id": [ { "id": "OXDD_BOVIN", "url": "https://www.uniprot.org/uniprot/P31228", "type": "external" } ], "mass": 37644.0, "length": 341, "protein_name": "D-aspartate oxidase", "gene_name": "DDO", "organism": "Bovine", "refseq_name": "D-aspartate oxidase", "refseq_ac": [ { "id": "NP_776333", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776333", "type": "external" } ], "gene_names_uniprotkb": "DDO", "gene_names_refseq": "DASPO; DDO", "protein_names_uniprotkb": "D-aspartate oxidase; 1.4.3.1; DASOX; DASPO; DDO", "protein_names_refseq": "D-aspartate oxidase; DASOX", "tax_id": 9913, "disease": "", "pathway": " (bta:280763)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10209293;1555574;1601857;2901415;3611051;7915543;8773567;9148742", "class_list": "", "function": "Selectively catalyzes the oxidative deamination of acidic amino acids (PubMed:10209293, PubMed:1555574, PubMed:2901415, PubMed:3611051, PubMed:7915543, PubMed:8773567). Suppresses the level of D-aspartate in the brain, an amino acid that can act as an agonist for glutamate receptors (By similarity). Protects the organism from the toxicity of D-amino acids (By similarity). May also function in the intestine (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Selectively catalyzes the oxidative deamination of acidic amino acids. Suppresses the level of D-aspartate in the brain, an amino acid that can act as an agonist for glutamate receptors. Protects the organism from the toxicity of D-amino acids. May also function in the intestine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1MP99;O02846;Q9TRA3", "ec_number_list": [ { "id": "1.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.1", "type": "external" } ], "go_molecular_function": "GO:0008445 D-aspartate oxidase activity;GO:0071949 FAD binding;GO:0047821 D-glutamate oxidase activity", "go_cellular_component": "GO:0005782 peroxisomal matrix;GO:0005829 cytosol", "go_biological_process": "GO:0019478 D-amino acid catabolic process;GO:0050877 nervous system process;GO:0006531 aspartate metabolic process;GO:0010646 regulation of cell communication", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P31228-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11023-1", "uniprot_id": [ { "id": "RAB3A_BOVIN", "url": "https://www.uniprot.org/uniprot/P11023", "type": "external" } ], "mass": 24954.0, "length": 220, "protein_name": "Ras-related protein Rab-3A", "gene_name": "RAB3A", "organism": "Bovine", "refseq_name": "ras-related protein Rab-3A", "refseq_ac": [ { "id": "NP_776871", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776871", "type": "external" } ], "gene_names_uniprotkb": "RAB3A", "gene_names_refseq": "RAB3A", "protein_names_uniprotkb": "Ras-related protein Rab-3A; 3.6.5.2; SMG P25A", "protein_names_refseq": "SMG P25A; ras-related protein Rab-3A", "tax_id": 9913, "disease": "", "pathway": " (bta:282029); (R-BTA-181429); (R-BTA-181430); (R-BTA-210500); (R-BTA-212676); (R-BTA-264642); (R-BTA-6798695); (R-BTA-8873719); (R-BTA-8876198); (R-BTA-888590)", "pathway_count": 10, "publication_count": 3, "publication_id_list": "14694148;1906176;3136152", "class_list": "", "function": "Rab3A in the GTP bound conformation prevents activity-dependent facilitation of exocytosis in bovine adrenal chromaffin cells, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB3A plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity). Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity). Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (By similarity). Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (By similarity). Also plays a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q17QM2", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "4.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.15", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031489 myosin V binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:0048790 maintenance of presynaptic active zone structure;GO:0050975 sensory perception of touch;GO:0003016 respiratory system process;GO:0007274 neuromuscular synaptic transmission;GO:0007409 axonogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P11023-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05126-1", "uniprot_id": [ { "id": "KPCB_BOVIN", "url": "https://www.uniprot.org/uniprot/P05126", "type": "external" } ], "mass": 76790.0, "length": 671, "protein_name": "Protein kinase C beta type", "gene_name": "PRKCB", "organism": "Bovine", "refseq_name": "protein kinase C beta type", "refseq_ac": [ { "id": "NP_777012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777012", "type": "external" } ], "gene_names_uniprotkb": "PRKCB; PRKCB1", "gene_names_refseq": "PRKCB1; PRKCB", "protein_names_uniprotkb": "Protein kinase C beta type; 2.7.11.13; PKC-B; PKC-beta", "protein_names_refseq": "PKC-B; PKC-beta; protein kinase C beta type; protein kinase C, beta 1 polypeptide", "tax_id": 9913, "disease": "", "pathway": " (bta:282325); (R-BTA-114516); (R-BTA-1169091); (R-BTA-416993); (R-BTA-4419969); (R-BTA-5099900); (R-BTA-5218921); (R-BTA-5668599); (R-BTA-76005)", "pathway_count": 9, "publication_count": 3, "publication_id_list": "23775122;3045562;3755548", "class_list": "", "function": "Acts as an activator of ferroptosis by mediating phosphorylation and activation of ACSL4. Also stimulates ferroptosis propagation by catalyzing phosphorylation of FOXK1., [UniProtKB, UniProtKB]; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. Participates in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Phosphorylates SLC2A1/GLUT1, promoting glucose uptake by SLC2A1/GLUT1. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription (By similarity). Phosphorylates KLHL3 in response to angiotensin II signaling, decreasing the interaction between KLHL3 and WNK4 (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The study identified the serine phosphorylation (p-Ser) sites induced by PKC-Beta activation or AGT, which inhibits insulin-induced p-Tyr sites on IRS2 and its signals in endothelial cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D7N0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0044305 calyx of Held;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0008091 spectrin", "go_biological_process": "GO:0010829 negative regulation of D-glucose transmembrane transport;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007207 phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P05126-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35384-1", "uniprot_id": [ { "id": "CASR_BOVIN", "url": "https://www.uniprot.org/uniprot/P35384", "type": "external" } ], "mass": 121171.0, "length": 1085, "protein_name": "Extracellular calcium-sensing receptor", "gene_name": "CASR", "organism": "Bovine", "refseq_name": "extracellular calcium-sensing receptor precursor", "refseq_ac": [ { "id": "NP_776427", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776427", "type": "external" } ], "gene_names_uniprotkb": "CASR; GPRC2A; PCAR1", "gene_names_refseq": "BoPCaR1; CASR", "protein_names_uniprotkb": "Extracellular calcium-sensing receptor; BoPCaR1; CaSR; PCaR1; Parathyroid cell calcium-sensing receptor", "protein_names_refseq": "PCaR1; calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism); extracellular calcium-sensing receptor precursor; extracellular calcium-sensing receptor; parathyroid Cell calcium-sensing receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:281038); (R-BTA-416476); (R-BTA-418594); (R-BTA-420499)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "28267410;8255296", "class_list": "", "function": "G protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:8255296). Senses fluctuations in the circulating calcium concentration: activated by elevated circulating calcium, leading to decreased parathyroid hormone (PTH) secretion in parathyroid glands (By similarity). In kidneys, acts as a key regulator of renal tubular calcium resorption (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. CASR is coupled with different G(q)/G(11), G(i)/G(o)- or G(s)-classes of G proteins depending on the context. In the parathyroid and kidney, CASR signals through G(q)/G(11) and G(i)/G(o) G proteins: G(q)/G(11) coupling activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers, while G(i)/G(o) coupling mediates inhibition of adenylate cyclase activity. The G protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation. Acts as an activator of the NLRP3 inflammasome via G(i)/G(o)-mediated signaling: down-regulation of cyclic AMP (cAMP) relieving NLRP3 inhibition by cAMP (By similarity). Acts as a regulator of proton-sensing receptor GPR68 in a seesaw manner: CASR-mediated signaling inhibits GPR68 signaling in response to extracellular calcium, while GPR68 inhibits CASR in presence of extracellular protons (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Studied the association of calcium-sensing receptor (CaSR) single nucleotide polymorphisms with growth traits in cattle., [RefSeq, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 10, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0016597 amino acid binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0043679 axon terminus", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P35384-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09487-1", "uniprot_id": [ { "id": "PPBT_BOVIN", "url": "https://www.uniprot.org/uniprot/P09487", "type": "external" } ], "mass": 57193.0, "length": 524, "protein_name": "Alkaline phosphatase, tissue-nonspecific isozyme", "gene_name": "ALPL", "organism": "Bovine", "refseq_name": "alkaline phosphatase, tissue-nonspecific isozyme precursor", "refseq_ac": [ { "id": "NP_789828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_789828", "type": "external" } ], "gene_names_uniprotkb": "ALPL", "gene_names_refseq": "ALPL; TNAP; TNS-AP", "protein_names_uniprotkb": "Alkaline phosphatase, tissue-nonspecific isozyme; 3.1.3.1; 3.9.1.1; AP-TNAP; Alkaline phosphatase liver/bone/kidney isozyme; Phosphoamidase; Phosphocreatine phosphatase; TNAP; TNSALP", "protein_names_refseq": "AP-TNAP; TNSALP; alkaline phosphatase liver/bone/kidney isozyme; alkaline phosphatase, liver/bone/kidney; alkaline phosphatase, tissue-nonspecific isozyme precursor; alkaline phosphatase, tissue-nonspecific isozyme; liver/bone/kidney isozyme; phosphoamidase; phosphocreatine phosphatase", "tax_id": 9913, "disease": "", "pathway": " (bta:280994); (R-BTA-163125)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15979580;17718598;19098289;23422881;3436527;3458202", "class_list": "", "function": "Alkaline phosphatase that metabolizes various phosphate compounds and plays a key role in skeletal mineralization and adaptive thermogenesis (By similarity). Has broad substrate specificity and can hydrolyze a considerable variety of compounds: however, only a few substrates, such as diphosphate (inorganic pyrophosphate; PPi), pyridoxal 5'-phosphate (PLP) and N-phosphocreatine are natural substrates (By similarity). Plays an essential role in skeletal and dental mineralization via its ability to hydrolyze extracellular diphosphate, a potent mineralization inhibitor, to phosphate: it thereby promotes hydroxyapatite crystal formation and increases inorganic phosphate concentration (PubMed:19098289). Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix (By similarity). Also promotes dephosphorylation of osteopontin (SSP1), an inhibitor of hydroxyapatite crystallization in its phosphorylated state; it is however unclear whether ALPL/TNAP mediates SSP1 dephosphorylation via a direct or indirect manner (By similarity). Catalyzes dephosphorylation of PLP to pyridoxal (PL), the transportable form of vitamin B6, in order to provide a sufficient amount of PLP in the brain, an essential cofactor for enzymes catalyzing the synthesis of diverse neurotransmitters (By similarity). Additionally, also able to mediate ATP degradation in a stepwise manner to adenosine, thereby regulating the availability of ligands for purinergic receptors (By similarity). Also capable of dephosphorylating microbial products, such as lipopolysaccharides (LPS) as well as other phosphorylated small-molecules, such as poly-inosine:cytosine (poly I:C) (By similarity). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating hydrolysis of N-phosphocreatine to initiate a futile cycle of creatine dephosphorylation and phosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; GPI-anchored proteins are localized on the outer layer of plasma membranes and clustered in microdomains generally called lipid rafts., [RefSeq, PubMed]; Results indicate that the presence of glycosylphosphatidylinositol increases the stability of alkaline phosphatase against chemical denaturation while it decreases its refolding yield by the artificial chaperone refolding technique., [RefSeq, PubMed]; The peri-partum characteristics of serum bone-specific alkaline phosphatase (BAP) and urinary deoxypyridinoline (DPD) in dairy cattle are reported., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q17QS5", "ec_number_list": [ { "id": "3.5.1.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.91", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.91", "type": "external" }, { "id": "3.1.3.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.89", "type": "external" }, { "id": "3.1.3.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.99", "type": "external" }, { "id": "3.1.3.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.35", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.3.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106", "type": "external" }, { "id": "3.6.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.16", "type": "external" }, { "id": "3.6.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.53", "type": "external" }, { "id": "3.4.11.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.9", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.3.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.75", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.1.4.50", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.50", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0016462 pyrophosphatase activity;GO:0033883 pyridoxal phosphatase activity;GO:0052732 phosphoethanolamine phosphatase activity;GO:0004035 alkaline phosphatase activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0065010 extracellular membrane-bounded organelle;GO:0005758 mitochondrial intermembrane space;GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0031214 biomineral tissue development;GO:0030282 bone mineralization;GO:0120162 positive regulation of cold-induced thermogenesis;GO:1904383 response to sodium phosphate;GO:0055062 phosphate ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P09487-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10568-1", "uniprot_id": [ { "id": "MYO1A_BOVIN", "url": "https://www.uniprot.org/uniprot/P10568", "type": "external" } ], "mass": 118869.0, "length": 1043, "protein_name": "Unconventional myosin-Ia", "gene_name": "MYO1A", "organism": "Bovine", "refseq_name": "unconventional myosin-Ia", "refseq_ac": [ { "id": "NP_776820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776820", "type": "external" } ], "gene_names_uniprotkb": "MYO1A; MYHL", "gene_names_refseq": "MYO1A", "protein_names_uniprotkb": "Unconventional myosin-Ia; BBM-I; BBMI; Brush border 110 kDa protein; Brush border myosin I; MIHC; Myosin I heavy chain", "protein_names_refseq": "BBM-I; BBMI; MIHC; brush border 110 kDa protein; brush border myosin I; myosin I heavy chain; myosin-Ia; unconventional myosin-Ia", "tax_id": 9913, "disease": "", "pathway": " (bta:281936)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1587791;3667594", "class_list": "", "function": "Involved in directing the movement of organelles along actin filaments., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2KJJ6;Q9TS38", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity;GO:0003779 actin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0015629 actin cytoskeleton;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0030048 actin filament-based movement;GO:0007605 sensory perception of sound;GO:0051648 vesicle localization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P10568-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22226-1", "uniprot_id": [ { "id": "CTHL1_BOVIN", "url": "https://www.uniprot.org/uniprot/P22226", "type": "external" } ], "mass": 17600.0, "length": 155, "protein_name": "Cathelicidin-1", "gene_name": "CATHL1; LOC132342071", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CATHL1; LOC132342071; BAC1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cathelicidin-1; Bac1; Bactenecin-1; Cyclic dodecapeptide", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:282164)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1459251;3290210;8706679", "class_list": "", "function": "Potent microbicidal activity; active against S.aureus and E.coli., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PJA3;Q24JY5", "ec_number_list": [], "go_molecular_function": "GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P22226-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1N588-1", "uniprot_id": [ { "id": "F1N588_BOVIN", "url": "https://www.uniprot.org/uniprot/F1N588", "type": "external" } ], "mass": 67388.0, "length": 612, "protein_name": "Sphingomyelin phosphodiesterase 2", "gene_name": "SMPD2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SMPD2", "gene_names_refseq": "", "protein_names_uniprotkb": "Sphingomyelin phosphodiesterase 2; 3.1.4.12; Lyso-platelet-activating factor-phospholipase C; Neutral sphingomyelinase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.12", "type": "external" }, { "id": "3.1.4.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.38", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004620 phospholipase activity;GO:0004767 sphingomyelin phosphodiesterase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006672 ceramide metabolic process;GO:0006685 sphingomyelin catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1N588-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P03969-1", "uniprot_id": [ { "id": "FGF2_BOVIN", "url": "https://www.uniprot.org/uniprot/P03969", "type": "external" } ], "mass": 17250.0, "length": 155, "protein_name": "Fibroblast growth factor 2", "gene_name": "FGF2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FGF2", "gene_names_refseq": "", "protein_names_uniprotkb": "Fibroblast growth factor 2; Basic fibroblast growth factor; FGF-2; HBGF-2; Heparin-binding growth factor 2; bFGF", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-109704); (R-BTA-1257604); (R-BTA-190322); (R-BTA-190370); (R-BTA-190372); (R-BTA-190373); (R-BTA-190375); (R-BTA-190377); (R-BTA-3000170); (R-BTA-5654219); (R-BTA-5654221); (R-BTA-5654227); (R-BTA-5654228); (R-BTA-5654687); (R-BTA-5654688); (R-BTA-5654689); (R-BTA-5654693); (R-BTA-5654695); (R-BTA-5654699); (R-BTA-5654700); (R-BTA-5654704); (R-BTA-5654706); (R-BTA-5654710); (R-BTA-5654712); (R-BTA-5654719); (R-BTA-5654720); (R-BTA-5654726); (R-BTA-5654727); (R-BTA-5654732); (R-BTA-5654733); (R-BTA-5658623); (R-BTA-5673001); (R-BTA-6811558); (R-BTA-9839397)", "pathway_count": 34, "publication_count": 11, "publication_id_list": "10867016;2425435;3472745;3556754;3596000;3741423;3809608;3863109;3940857;4081126;6591194", "class_list": "", "function": "Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Also acts as an integrin ligand which is required for FGF2 signaling (By similarity). Binds to integrin ITGAV:ITGB3 (By similarity). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (By similarity). Functions as a potent mitogen in vitro (By similarity). Can induce angiogenesis (By similarity). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0001525 angiogenesis;GO:0001934 positive regulation of protein phosphorylation;GO:0007165 signal transduction;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P03969-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04421-1", "uniprot_id": [ { "id": "LYSC_BOVIN", "url": "https://www.uniprot.org/uniprot/P04421", "type": "external" } ], "mass": 16373.0, "length": 147, "protein_name": "Lysozyme C", "gene_name": "LYZ1", "organism": "Bovine", "refseq_name": "lysozyme C-1 precursor", "refseq_ac": [ { "id": "NP_001073808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073808", "type": "external" } ], "gene_names_uniprotkb": "LYZ1", "gene_names_refseq": "LOC781349; LYSOZYME; LYZ1; LYZF4; LYZ", "protein_names_uniprotkb": "Lysozyme C; 1,4-beta-N-acetylmuramidase C; 3.2.1.17", "protein_names_refseq": "1,4-beta-N-acetylmuramidase C; lysozyme C-1 precursor; lysozyme C-1; lysozyme F4", "tax_id": 9913, "disease": "", "pathway": " (bta:280849); (bta:281289); (bta:781349)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "19348005;2504928;2738070;6470012", "class_list": "glycogene;glycosylhydrolase", "function": "In this investigation, we obtained the crystallographic structure of recombinant bovine stomach lysozyme 2 (BSL2)., [RefSeq, PubMed]; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0007586 digestion;GO:0031640 killing of cells of another organism", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P04421-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05128-1", "uniprot_id": [ { "id": "KPCG_BOVIN", "url": "https://www.uniprot.org/uniprot/P05128", "type": "external" } ], "mass": 77156.0, "length": 682, "protein_name": "Protein kinase C gamma type", "gene_name": "PRKCG", "organism": "Bovine", "refseq_name": "protein kinase C gamma type", "refseq_ac": [ { "id": "NP_001159974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159974", "type": "external" } ], "gene_names_uniprotkb": "PRKCG", "gene_names_refseq": "PRKCG", "protein_names_uniprotkb": "Protein kinase C gamma type; 2.7.11.13; PKC-gamma", "protein_names_refseq": "PKC-gamma; protein kinase C gamma type; putative protein kinase C gamma type", "tax_id": 9913, "disease": "", "pathway": " (bta:282002)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "3045562;3755548", "class_list": "", "function": "Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress. Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock. Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0048471 perinuclear region of cytoplasm;GO:0099524 postsynaptic cytosol", "go_biological_process": "GO:0032095 regulation of response to food;GO:0035556 intracellular signal transduction;GO:0043524 negative regulation of neuron apoptotic process;GO:0043278 response to morphine;GO:0042752 regulation of circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P05128-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05185-1", "uniprot_id": [ { "id": "CP17A_BOVIN", "url": "https://www.uniprot.org/uniprot/P05185", "type": "external" } ], "mass": 57244.0, "length": 509, "protein_name": "Steroid 17-alpha-hydroxylase/17,20 lyase", "gene_name": "CYP17A1", "organism": "Bovine", "refseq_name": "steroid 17-alpha-hydroxylase/17,20 lyase precursor", "refseq_ac": [ { "id": "NP_776729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776729", "type": "external" } ], "gene_names_uniprotkb": "CYP17A1; CYP17", "gene_names_refseq": "CYP17A1; CYP17; CYPXVII; P450-C17; P450c17", "protein_names_uniprotkb": "Steroid 17-alpha-hydroxylase/17,20 lyase; 1.14.14.19; 1.14.14.32; 17-alpha-hydroxyprogesterone aldolase; CYPXVII; Cytochrome P450 17A1; Cytochrome P450-C17; Cytochrome P450c17; Steroid 17-alpha-monooxygenase", "protein_names_refseq": "17-alpha-hydroxyprogesterone aldolase; cytochrome P450 17A1; cytochrome P450, family 17, subfamily A, polypeptide 1; cytochrome P450, subfamily XVII; cytochrome P450-C17; cytochrome P450c17; steroid 17-alpha-hydroxylase/17,20 lyase precursor; steroid 17-alpha-hydroxylase/17,20 lyase; steroid 17-alpha-hydroxylase; steroid 17-alpha-monooxygenase", "tax_id": 9913, "disease": "", "pathway": " (bta:281739); (R-BTA-193048); (R-BTA-194002)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "22217838;22405876;23530236;2543297;29981252;3003117;32199904", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)., [UniProtKB, UniProtKB]; BMP6 has a role in downregulating INSL3 and CYP17A1 and other proteins that modulate ovarian androgen production, [RefSeq, PubMed]; By alignment analysis and sequencing, we detected that the g.329C>T SNP is a false positive polymorphism, which allows us to explain the inflated heterozygotic value., [RefSeq, PubMed]; Data suggest that the upstream region of gene encoding CYP17 contains unique cAMP-responsive sequence and appears to bind unique nuclear proteins or transcription factors in adrenal cortex. [REVIEW] Review article, [RefSeq, PubMed]; Inhibition of autophagy in theca cells induces CYP17A1 and PAI-1 expression via ROS/p38 and JNK signalling during the development of polycystic ovary syndrome., [RefSeq, PubMed]; This study focused on the reaction of the bovine CYP17A1 enzyme with progesterone as a substrate. On the basis of a created homology model, active-site residues were identified and systematically mutated to alanine. In whole-cell biotransformations, the importance of the N202, R239, G297 and E305 residues for substrate conversion was confirmed., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2YDL3", "ec_number_list": [ { "id": "1.14.14.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.19", "type": "external" }, { "id": "1.14.14.32", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.32", "type": "external" }, { "id": "1.14.14.25", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.25", "type": "external" }, { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016829 lyase activity;GO:0004508 steroid 17-alpha-monooxygenase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0042446 hormone biosynthetic process;GO:0006704 glucocorticoid biosynthetic process;GO:0008202 steroid metabolic process;GO:0042448 progesterone metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P05185-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05307-1", "uniprot_id": [ { "id": "PDIA1_BOVIN", "url": "https://www.uniprot.org/uniprot/P05307", "type": "external" } ], "mass": 57266.0, "length": 510, "protein_name": "Protein disulfide-isomerase", "gene_name": "P4HB", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "P4HB; PDIA1", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein disulfide-isomerase; 5.3.4.1; Cellular thyroid hormone-binding protein; PDI; Prolyl 4-hydroxylase subunit beta; p55", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:281373)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2351674;3619939", "class_list": "", "function": "This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0003756 protein disulfide isomerase activity;GO:0004656 procollagen-proline 4-dioxygenase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0009897 external side of plasma membrane;GO:0042470 melanosome", "go_biological_process": "GO:0006457 protein folding;GO:0034976 response to endoplasmic reticulum stress;GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P05307-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05630-1", "uniprot_id": [ { "id": "ATPD_BOVIN", "url": "https://www.uniprot.org/uniprot/P05630", "type": "external" } ], "mass": 17612.0, "length": 168, "protein_name": "ATP synthase F(1) complex subunit delta, mitochondrial", "gene_name": "ATP5F1D", "organism": "Bovine", "refseq_name": "ATP synthase F(1) complex subunit delta, mitochondrial precursor", "refseq_ac": [ { "id": "NP_788843", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788843", "type": "external" } ], "gene_names_uniprotkb": "ATP5F1D; ATP5D", "gene_names_refseq": "ATP5D; ATP5F1D", "protein_names_uniprotkb": "ATP synthase F(1) complex subunit delta, mitochondrial; ATP synthase F1 subunit delta; F-ATPase delta subunit", "protein_names_refseq": "ATP synthase F(1) complex subunit delta, mitochondrial precursor; ATP synthase F(1) complex subunit delta, mitochondrial; ATP synthase subunit delta, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit; F-ATPase delta subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:338081); (R-BTA-163210); (R-BTA-8949613)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "17570365;17895376;1827992;2138455;25851905;28100784;2864455;8065448", "class_list": "", "function": "Subunit delta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the central stalk subunit gamma, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H7D8", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity;GO:0015078 proton transmembrane transporter activity;GO:0046933 proton-transporting ATP synthase activity, rotational mechanism", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005740 mitochondrial envelope;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly;GO:0009060 aerobic respiration;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P05630-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06394-1", "uniprot_id": [ { "id": "K1C10_BOVIN", "url": "https://www.uniprot.org/uniprot/P06394", "type": "external" } ], "mass": 54848.0, "length": 526, "protein_name": "Keratin, type I cytoskeletal 10", "gene_name": "KRT10", "organism": "Bovine", "refseq_name": "keratin, type I cytoskeletal 10 isoform 1", "refseq_ac": [ { "id": "NP_776802", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776802", "type": "external" } ], "gene_names_uniprotkb": "KRT10", "gene_names_refseq": "KRT10", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 10; CK-10; Cytokeratin VIB; Cytokeratin-10; Cytokeratin-6B; K10; Keratin-10", "protein_names_refseq": "CK-10; K10; cytokeratin VIB; cytokeratin-10; cytokeratin-6B; epidermolytic hyperkeratosis; keratin 10 (epidermolytic hyperkeratosis); keratin, type I cytoskeletal 10 isoform 1; keratin, type I cytoskeletal 10; keratosis palmaris et plantaris", "tax_id": 9913, "disease": "", "pathway": " (bta:281888)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "2416562;26495903;41018975;6209405", "class_list": "", "function": "Structural component of intermediate filaments in suprabasal keratinocytes of stratified epithelia. Forms heteropolymers primarily with the type II keratin KRT1, and also with KRT2, assembling into intermediate filament networks that support terminal differentiation, mechanical resilience, and epidermal barrier formation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0009986 cell surface;GO:0045095 keratin filament", "go_biological_process": "GO:0030216 keratinocyte differentiation;GO:0051290 protein heterotetramerization;GO:0045109 intermediate filament organization;GO:0045684 positive regulation of epidermis development;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P06394-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P06868-1", "uniprot_id": [ { "id": "PLMN_BOVIN", "url": "https://www.uniprot.org/uniprot/P06868", "type": "external" } ], "mass": 90491.0, "length": 805, "protein_name": "Plasminogen", "gene_name": "PLG", "organism": "Bovine", "refseq_name": "plasminogen precursor", "refseq_ac": [ { "id": "NP_776376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776376", "type": "external" } ], "gene_names_uniprotkb": "PLG", "gene_names_refseq": "LPA; PLG", "protein_names_uniprotkb": "Plasminogen", "protein_names_refseq": "lipoprotein, Lp(a); plasminogen precursor; plasmin", "tax_id": 9913, "disease": "", "pathway": " (bta:280897)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "19638263;22177313;22518846;3356193;3846532;6148961", "class_list": "", "function": "Has an antiangiogenic activity and inhibits neovascularization. Could act through the inhibition of the ATP synthase subunit ATP5F1A., [UniProtKB, UniProtKB]; Protease which primary function is to degrade fibrin, the main component of blood clots. Also cleaves other components of blood clots like thrombospondin-1/THBS1 and von Willebrand factor/VWF. Can also directly and/or through the activation of other proteases degrade the various components of the extracellular matrix including collagen, fibronectin and laminin. Thereby, regulates a variety of biological processes including embryonic development, tissue remodeling, and inflammation (By similarity). In ovulation, weakens the walls of the Graafian follicle (By similarity). In vitro, it is also able to cleave several complement zymogens, such as C1, C4 and C5 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; SUPA formed a higher avidity complex (118-fold) with bovine Pg than with human Pg and non-proteolytically activated bovine but not human Pg., [RefSeq, PubMed]; The current study suggests the existence of an active TNF-alpha-plasminogen-plasmin autocrine/paracrine loop on the massively infiltrated polymorphonuclear neutrophils inside udders of drying-off cows., [RefSeq, PubMed]; The plasminogen/plasminogen activator/plasmin system is activated during gamete interaction and regulates the sperm entry into the oocyte., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q28162", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0005102 signaling receptor binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation;GO:0042730 fibrinolysis;GO:0009408 response to heat;GO:0048771 tissue remodeling", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P06868-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1100000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07501-1", "uniprot_id": [ { "id": "ANF_BOVIN", "url": "https://www.uniprot.org/uniprot/P07501", "type": "external" } ], "mass": 16518.0, "length": 152, "protein_name": "Natriuretic peptides A", "gene_name": "NPPA", "organism": "Bovine", "refseq_name": "natriuretic peptides A precursor", "refseq_ac": [ { "id": "NP_776549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776549", "type": "external" } ], "gene_names_uniprotkb": "NPPA", "gene_names_refseq": "CDD; NPPA", "protein_names_uniprotkb": "Natriuretic peptides A; ANF 1-33; ANF 3-33; ANF 8-33; ANF; Alpha-atrial natriuretic peptide; Alpha-hANP; Atrial natriuretic factor 1-33; Atrial natriuretic factor 3-33; Atrial natriuretic factor 8-33; Atrial natriuretic factor prohormone; Atrial natriuretic factor; Atrial natriuretic peptide prohormone; Atriopeptigen; Atriopeptin III; Atriopeptin II; Atriopeptin I; CDD 95-126; CDD-ANF; CDD-ANP (95-126); CDD-ANP (99-126); CDD; Cardiodilatin; Cardionatrin; LANH; Long-acting natriuretic hormone; Pro atrial natriuretic factor 1-30; Pro atrial natriuretic factor 31-67; Pro atrial natriuretic factor 79-98; Pro atrial natriuretic factor 99-126; Pro atrial natriuretic peptide 1-30; Pro atrial natriuretic peptide 31-67; Pro atrial natriuretic peptide 79-98; Pro atrial natriuretic peptide 95-126; preproANF; preproANP; preproCDD-ANF; proANF 1-30; proANF 31-67; proANF 79-98; proANF 99-126; proANF; proANP 1-30; proANP 31-67; proANP 79-98; proANP 95-126; proANP", "protein_names_refseq": "ANF; ANP; atrial natriuretic factor prohormone; atrial natriuretic peptide prohormone; atriopeptigen; cardiodilatin; natriuretic peptide precursor A; natriuretic peptides A precursor; natriuretic peptides A; preproANF; preproANP; preproCDD-ANF; prepronatriodilatin; proANF; proANP", "tax_id": 9913, "disease": "", "pathway": " (bta:281355); (R-BTA-5578768)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12213803;2939830;3007908", "class_list": "", "function": "ANP acts as an anti-permeability factor by inhibiting the signaling functions of vascular permeability factor and by preserving the endothelial cell tight junctions functional morphology, [RefSeq, PubMed]; Hormone produced in the kidneys that appears to be important for maintaining cardio-renal homeostasis. Mediates vasodilation, natriuresis and diuresis primarily in the renal system, in order to maintain the extracellular fluid volume and control the fluid-electrolyte balance. Specifically binds and stimulates cGMP production by renal transmembrane receptors, likely NPR1. Urodilatin not ANP, may be the natriuretic peptide responsible for the regulation of sodium and water homeostasis in the kidney., [UniProtKB, UniProtKB]; Hormone that plays a key role in mediating cardio-renal homeostasis, and is involved in vascular remodeling and regulating energy metabolism (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins, such as PRKG1, that drive various biological responses (By similarity). Regulates vasodilation, natriuresis, diuresis and aldosterone synthesis and is therefore essential for regulating blood pressure, controlling the extracellular fluid volume and maintaining the fluid-electrolyte balance (By similarity). Also involved in inhibiting cardiac remodeling and cardiac hypertrophy by inducing cardiomyocyte apoptosis and attenuating the growth of cardiomyocytes and fibroblasts (By similarity). Plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus, and thus prevents pregnancy-induced hypertension (By similarity). In adipose tissue, acts in various cGMP- and PKG-dependent pathways to regulate lipid metabolism and energy homeostasis (By similarity). This includes up-regulating lipid metabolism and mitochondrial oxygen utilization by activating the AMP-activated protein kinase (AMPK), and increasing energy expenditure by acting via MAPK11 to promote the UCP1-dependent thermogenesis of brown adipose tissue (By similarity). Binds the clearance receptor NPR3 which removes the hormone from circulation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; May have a role in cardio-renal homeostasis through regulation of diuresis and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. May have a role in potassium excretion but not sodium excretion (natriuresis). Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption., [UniProtKB, UniProtKB]; May have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo promotes natriuresis and in vitro, vasodilates renal artery strips., [UniProtKB, UniProtKB]; May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, and vasodilation. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase. However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis. Appears to bind to specific receptors that are distinct from the receptors bound by the atrial natriuretic and long-acting natriuretic peptides. Possibly functions in protein excretion in urine by maintaining the integrity of the proximal tubules and enhancing protein excretion by decreasing proximal tubular protein reabsorption., [UniProtKB, UniProtKB]; May have a role in cardio-renal homeostasis through regulation of natriuresis, diuresis, vasodilation, and inhibiting aldosterone synthesis. In vitro, promotes the production of cGMP and induces vasodilation. May promote natriuresis, at least in part, by enhancing prostaglandin E2 synthesis resulting in the inhibition of renal Na+-K+-ATPase (By similarity). However reports on the involvement of this peptide in mammal blood volume and blood pressure homeostasis are conflicting; according to a report, in vivo it is not sufficient to activate cGMP and does not inhibit collecting duct transport nor effect diuresis and natriuresis (By similarity). Appears to bind to specific receptors that are distinct from the receptors bound by atrial natriuretic peptide and vessel dilator. Possibly enhances protein excretion in urine by decreasing proximal tubular protein reabsorption (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; May have a role in cardio-renal homeostasis through regulation of regulation of natriuresis and vasodilation. In vivo promotes natriuresis. In vitro, vasodilates intestinal smooth muscle but not smooth muscle strips., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QNW0", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0005179 hormone activity;GO:0051427 hormone receptor binding;GO:0071855 neuropeptide receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0043204 perikaryon;GO:0042995 cell projection;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006182 cGMP biosynthetic process;GO:0007218 neuropeptide signaling pathway;GO:0008217 regulation of blood pressure;GO:0042311 vasodilation;GO:0007565 female pregnancy", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P07501-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07857-1", "uniprot_id": [ { "id": "SCP2_BOVIN", "url": "https://www.uniprot.org/uniprot/P07857", "type": "external" } ], "mass": 58577.0, "length": 543, "protein_name": "Sterol carrier protein 2", "gene_name": "SCP2", "organism": "Bovine", "refseq_name": "sterol carrier protein 2", "refseq_ac": [ { "id": "NP_001029162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029162", "type": "external" } ], "gene_names_uniprotkb": "SCP2", "gene_names_refseq": "SCP2; SCPX", "protein_names_uniprotkb": "Sterol carrier protein 2; 2.3.1.155; 2.3.1.16; 2.3.1.176; Acetyl-CoA C-myristoyltransferase; NSL-TP; Non-specific lipid-transfer protein; Propanoyl-CoA C-acyltransferase; SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; SCP-2; SCP-X; SCP-chi; SCPX; Sterol carrier protein X", "protein_names_refseq": "NSL-TP; SCP-2/3-oxoacyl-CoA thiolase; SCP-2/thiolase; SCP-2; SCP-X; SCP-chi; acetyl-CoA C-myristoyltransferase; non-specific lipid-transfer protein; propanoyl-CoA C-acyltransferase; sterol carrier protein 2; sterol carrier protein X", "tax_id": 9913, "disease": "", "pathway": " (bta:508918)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15449949;3977925", "class_list": "", "function": "By trafficking cholesterol hydroperoxides and phospholipid hydroperoxides in addition to parent lipids, SCP2 may exacerbate cell injury under oxidative stress conditions. [sterol carrier protein 2, SCP2, nonspecific lipid transfer protein], [RefSeq, PubMed]; Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis (By similarity). Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol (By similarity). Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA) (By similarity). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (By similarity). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SYV0", "ec_number_list": [ { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" } ], "go_molecular_function": "GO:0033814 propanoyl-CoA C-acyltransferase activity;GO:0050632 propionyl-CoA C2-trimethyltridecanoyltransferase activity;GO:0008289 lipid binding;GO:0003988 acetyl-CoA C-acyltransferase activity;GO:0003985 acetyl-CoA C-acetyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0032385 positive regulation of intracellular cholesterol transport;GO:1901373 lipid hydroperoxide transport;GO:0006635 fatty acid beta-oxidation;GO:0032367 intracellular cholesterol transport;GO:0008206 bile acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P07857-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07995-1", "uniprot_id": [ { "id": "INHBA_BOVIN", "url": "https://www.uniprot.org/uniprot/P07995", "type": "external" } ], "mass": 47521.0, "length": 425, "protein_name": "Inhibin beta A chain", "gene_name": "INHBA", "organism": "Bovine", "refseq_name": "inhibin beta A chain precursor", "refseq_ac": [ { "id": "NP_776788", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776788", "type": "external" } ], "gene_names_uniprotkb": "INHBA", "gene_names_refseq": "INHBA", "protein_names_uniprotkb": "Inhibin beta A chain; Activin beta-A chain", "protein_names_refseq": "activin beta-A chain; inhibin beta A chain precursor; inhibin beta A chain; inhibin beta A subunit; inhibin, beta A (activin A, activin AB alpha polypeptide)", "tax_id": 9913, "disease": "", "pathway": " (bta:281867); (R-BTA-1502540); (R-BTA-201451); (R-BTA-209822); (R-BTA-2473224); (R-BTA-9839406)", "pathway_count": 6, "publication_count": 7, "publication_id_list": "15196700;1733725;20739376;25001504;27185102;3458167;7813465", "class_list": "", "function": "Activin A is a homodimer of INHBA that plays a role in several essential biological processes including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and tissue fibrosis. Signals through type I (such as ACVR1B or ACVR1C) and type II receptors (such as ACVR2A, ACVR2B or BMPR2) which, upon ligand binding, phosphorylate SMAD2 and SMAD3 intracellular signaling mediators that form a complex with SMAD4, translocate to the nucleus and modulate gene expression. Can also activate alternative non-canonical intracellular signaling pathways including the p38 MAPK, extracellular signal-regulated kinases 1/2 (ERK1/2) and c-Jun N-terminal kinases (JNKs) to modulate cell migration and differentiation. Alternatively, promotes osteoblastic differentiation via ACVRL1-SMAD1/5/9 pathway. In addition, can engage the type I receptor ACVR1 to form an ACVR1-activin A-type II receptor non-signaling complex (NSC) that renders receptors unavailable for engagement with BMPs, hence resulting in an apparent inhibition of ACVR1-mediated BMP signaling., [UniProtKB, UniProtKB]; Activin AB is a lignd for activin type IB receptor ALK7 and is responsible for activin-mediated secretion of insulin from pancreatic beta cell line, MIN6., [RefSeq, PubMed]; Inhibin A is a dimer of alpha/INHA and beta-A/INHBA that functions as a feedback regulator in the hypothalamic-pituitary-gonadal (HPG) axis. Inhibits the secretion of FSH from the anterior pituitary gland by acting on pituitary gonadotrope cells. Antagonizes activin A by binding to the proteoglycan, betaglycan, and forming a stable complex with and, thereby, sequestering type II activin receptors while excluding type I receptor., [UniProtKB, UniProtKB]; Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition., [UniProtKB, UniProtKB]; Results confirm the prodevelopmental actions of activin A and indicate that CTGF may also function as an embryokine by regulating the number of ICM cells in the blastocyst and altering gene expression. Low concentrations of HGF were inhibitory to development., [RefSeq, PubMed]; Results support a physiological role for granulosa-derived inhibin as an antagonist of bone morphogenetic protein action on thecal androgen synthesis., [RefSeq, PubMed]; The expression of the components of the activin-inhibin-follistatin system is altered in bovine cystic ovarian disease., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0JN81", "ec_number_list": [], "go_molecular_function": "GO:0070699 type II activin receptor binding;GO:0042802 identical protein binding;GO:0005125 cytokine activity;GO:0017046 peptide hormone binding;GO:0005179 hormone activity", "go_cellular_component": "GO:0043509 activin A complex;GO:0043512 inhibin A complex;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0046880 regulation of follicle-stimulating hormone secretion;GO:0060279 positive regulation of ovulation;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P07995-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08169-1", "uniprot_id": [ { "id": "MPRI_BOVIN", "url": "https://www.uniprot.org/uniprot/P08169", "type": "external" } ], "mass": 274529.0, "length": 2499, "protein_name": "Cation-independent mannose-6-phosphate receptor", "gene_name": "IGF2R", "organism": "Bovine", "refseq_name": "cation-independent mannose-6-phosphate receptor precursor", "refseq_ac": [ { "id": "NP_776777", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776777", "type": "external" } ], "gene_names_uniprotkb": "IGF2R; M6P", "gene_names_refseq": "CI-MPR; CIMPR; IGF2R", "protein_names_uniprotkb": "Cation-independent mannose-6-phosphate receptor; 300 kDa mannose 6-phosphate receptor; CI Man-6-P receptor; CI-MPR; IGF-II receptor; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; M6PR; MPR 300", "protein_names_refseq": "300 kDa mannose 6-phosphate receptor; CI Man-6-P receptor; IGF-II receptor; M6PR; MPR 300; cation-independent mannose-6-phosphate receptor precursor; cation-independent mannose-6-phosphate receptor; insulin-like growth factor II receptor; insulin-like growth factor receptor type 2", "tax_id": 9913, "disease": "", "pathway": " (bta:281849)", "pathway_count": 1, "publication_count": 12, "publication_id_list": "15085180;15169779;20615935;2545438;28978943;2951738;2963004;29785901;32095534;34626867;34971973;8416996", "class_list": "", "function": "Components of the insulin-like growth factor system in in vivo - and in vitro-derived fetuses of cattle, and the association with growth and development., [RefSeq, PubMed]; Genomic imprinting of the IGF2R/AIR locus is conserved between bovines and mice., [RefSeq, PubMed]; Here we examined the transcriptome of skeletal muscle, liver, kidney, and brain of control and LOS bovine fetuses and found that different tissues within LOS fetuses have perturbations of distinct gene pathways... only a small percent of differentially expressed genes (DEGs), including the imprinted gene IGF2R, could be associated with the neighboring differentially methylated regions Publication Status: Online-Only, [RefSeq, PubMed]; Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4., [UniProtKB, UniProtKB]; Suggest that the insulin like growth factor 2 receptor(IGF2R) gene polymorphisms could be useful genetic markers for dairy production traits in cattle, [RefSeq, PubMed]", "predicted_glycosites": 16, "predicted_n_glycosites": 15, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 20, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051219 phosphoprotein binding;GO:0005520 insulin-like growth factor binding;GO:0005537 D-mannose binding;GO:0036143 kringle domain binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0005770 late endosome", "go_biological_process": "GO:0006622 protein targeting to lysosome", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P08169-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.010000000000000000.1000000011001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08760-1", "uniprot_id": [ { "id": "KAD3_BOVIN", "url": "https://www.uniprot.org/uniprot/P08760", "type": "external" } ], "mass": 25671.0, "length": 227, "protein_name": "GTP:AMP phosphotransferase AK3, mitochondrial", "gene_name": "AK3", "organism": "Bovine", "refseq_name": "GTP:AMP phosphotransferase AK3, mitochondrial", "refseq_ac": [ { "id": "NP_776662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776662", "type": "external" } ], "gene_names_uniprotkb": "AK3", "gene_names_refseq": "AK3L1; AK3", "protein_names_uniprotkb": "GTP:AMP phosphotransferase AK3, mitochondrial; 2.7.4.10; Adenylate kinase 3; Adenylate kinase isozyme 3", "protein_names_refseq": "AK 3; GTP:AMP phosphotransferase AK3, mitochondrial; GTP:AMP phosphotransferase, mitochondrial; adenylate kinase 3 alpha-like 1; adenylate kinase 3-like 1; adenylate kinase isozyme 3", "tax_id": 9913, "disease": "", "pathway": " (bta:281613); (R-BTA-983231)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "1748300;1994037;2175649;2478555;3013690;6088234", "class_list": "", "function": "Mitochondrial adenylate kinase with a specific GTP:AMP phosphotransferase activity. Could also use ITP as phosphate donor. Its physiological function is to recycle GTP into GDP which is necessary for the TCA cycle in the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29RI4", "ec_number_list": [ { "id": "2.7.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" } ], "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0046899 nucleoside triphosphate adenylate kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006172 ADP biosynthetic process;GO:0046033 AMP metabolic process;GO:0046041 ITP metabolic process;GO:0046051 UTP metabolic process;GO:0046039 GTP metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P08760-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08904-1", "uniprot_id": [ { "id": "RNAS6_BOVIN", "url": "https://www.uniprot.org/uniprot/P08904", "type": "external" } ], "mass": 17661.0, "length": 154, "protein_name": "Ribonuclease K6", "gene_name": "RNASE6", "organism": "Bovine", "refseq_name": "ribonuclease K6 precursor", "refseq_ac": [ { "id": "NP_777019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777019", "type": "external" } ], "gene_names_uniprotkb": "RNASE6; RK6B; RNS6", "gene_names_refseq": "RNASE6", "protein_names_uniprotkb": "Ribonuclease K6; 3.1.27.-; K6b; RNase K2; RNase K6; Ribonuclease K2", "protein_names_refseq": "K6b; RNase K2; RNase K6; ribonuclease K2; ribonuclease K6 precursor; ribonuclease k6; ribonuclease, RNase A family, k6", "tax_id": 9913, "disease": "", "pathway": " (bta:282341); (R-BTA-6803157)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "11092753;3182769;3926759;8836175", "class_list": "", "function": "Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed:3926759). Has potent antimicrobial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (By similarity). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (By similarity). Probably contributes to urinary tract sterility (By similarity). Bactericidal activity is independent of RNase activity (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q32L16;Q95324;Q9TUP9", "ec_number_list": [ { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0004519 endonuclease activity;GO:0004540 RNA nuclease activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P08904-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C2H4-1", "uniprot_id": [ { "id": "DSE_BOVIN", "url": "https://www.uniprot.org/uniprot/P0C2H4", "type": "external" } ], "mass": 109725.0, "length": 958, "protein_name": "Dermatan-sulfate epimerase", "gene_name": "DSE", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DSE", "gene_names_refseq": "", "protein_names_uniprotkb": "Dermatan-sulfate epimerase; 5.1.3.19; Chondroitin-glucuronate 5-epimerase; DS epimerase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "16505484", "class_list": "", "function": "Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues. Plays an important role in the biosynthesis of the glycosaminoglycan/mucopolysaccharide dermatan sulfate., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.1.3.19", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.19", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0047757 chondroitin-glucuronate 5-epimerase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0050655 dermatan sulfate proteoglycan metabolic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0050654 chondroitin sulfate proteoglycan metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C2H4-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C7Q4-1", "uniprot_id": [ { "id": "GNAT3_BOVIN", "url": "https://www.uniprot.org/uniprot/P0C7Q4", "type": "external" } ], "mass": 40332.0, "length": 354, "protein_name": "Guanine nucleotide-binding protein G(t) subunit alpha-3", "gene_name": "GNAT3", "organism": "Bovine", "refseq_name": "guanine nucleotide-binding protein G(t) subunit alpha-3", "refseq_ac": [ { "id": "NP_001103452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103452", "type": "external" } ], "gene_names_uniprotkb": "GNAT3", "gene_names_refseq": "GNAT3; HG1E", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(t) subunit alpha-3; Gustducin alpha-3 chain", "protein_names_refseq": "alpha-gustducin; guanine nucleotide binding protein, alpha transducing 3; guanine nucleotide-binding protein G(t) subunit alpha-3; gustducin alpha-3 chain; heterotrimeric guanine nucleotide-binding protein 1E", "tax_id": 9913, "disease": "", "pathway": " (bta:516262); (R-BTA-170670); (R-BTA-381771); (R-BTA-392170); (R-BTA-418594); (R-BTA-9009391); (R-BTA-9717207)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "16928202;17021831;9671782", "class_list": "", "function": "Axonemal-associated localization within the midpiece and principal piece of bovine spermatozoa raises the possibility that this G protein alpha-subunit may process intracellular signals controlling sperm motility, [RefSeq, PubMed]; Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005834 heterotrimeric G-protein complex;GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0007603 phototransduction, visible light;GO:0050908 detection of light stimulus involved in visual perception;GO:0050916 sensory perception of sweet taste", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0C7Q4-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10064-1", "uniprot_id": [ { "id": "GBRA3_BOVIN", "url": "https://www.uniprot.org/uniprot/P10064", "type": "external" } ], "mass": 55284.0, "length": 492, "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-3", "gene_name": "GABRA3", "organism": "Bovine", "refseq_name": "gamma-aminobutyric acid receptor subunit alpha-3 precursor", "refseq_ac": [ { "id": "NP_776967", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776967", "type": "external" } ], "gene_names_uniprotkb": "GABRA3", "gene_names_refseq": "GABRA3", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit alpha-3; GABA(A) receptor subunit alpha-3; GABAAR subunit alpha-3", "protein_names_refseq": "GABA(A) receptor subunit alpha-3; GABAAR subunit alpha-3; gamma-aminobutyric acid (GABA) A receptor, alpha 3; gamma-aminobutyric acid receptor subunit alpha-3 precursor; gamma-aminobutyric acid receptor subunit alpha-3; gamma-aminobutyric acid type A receptor alpha3 subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:282237)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2842688", "class_list": "", "function": "Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0098794 postsynapse;GO:0034707 chloride channel complex;GO:0032590 dendrite membrane;GO:1902711 GABA-A receptor complex", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P10064-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10861-1", "uniprot_id": [ { "id": "UCP1_BOVIN", "url": "https://www.uniprot.org/uniprot/P10861", "type": "external" } ], "mass": 33360.0, "length": 309, "protein_name": "Mitochondrial brown fat uncoupling protein 1", "gene_name": "UCP1", "organism": "Bovine", "refseq_name": "mitochondrial brown fat uncoupling protein 1", "refseq_ac": [ { "id": "NP_001160000", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160000", "type": "external" } ], "gene_names_uniprotkb": "UCP1; SLC25A7; UCP", "gene_names_refseq": "UCP1", "protein_names_uniprotkb": "Mitochondrial brown fat uncoupling protein 1; Solute carrier family 25 member 7; Thermogenin; UCP 1", "protein_names_refseq": "UCP 1; mitochondrial brown fat uncoupling protein 1; mitochondrial, proton carrier; solute carrier family 25 member 7; thermogenin", "tax_id": 9913, "disease": "", "pathway": " (bta:281561); (R-BTA-166187); (R-BTA-167826)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "15339748;19393038;19427838;27691991;28046166;2928121;33006416;37062711", "class_list": "", "function": "Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria., [UniProtKB, UniProtKB]; Possibility of uncoupling protein 1 expression in bovine fast-twitch muscle fibers., [RefSeq, PubMed]; Regulatory expression of uncoupling protein 1 and its related genes by endogenous activity of the transforming growth factor-beta family in bovine myogenic cells., [RefSeq, PubMed]; Study suggests that uncoupling protein 1 affects milk yield, milk fat percentage and milk protein percentage, [RefSeq, PubMed]; The results of the present study provide an insight into the unexpected expression of Ucp1 in bovine skeletal muscle, which suggests the necessity for further studies on Ucp1-mediated energy expenditure in bovine skeletal muscle., [RefSeq, PubMed]; These results suggest that CIDE-A and UCP1 are regulated by insulin and/or fatty acids in mammary epithelial cells and lactating mammary glands, and thereby play an important role in lipid and energy metabolism., [RefSeq, PubMed]; UCPs do have uncoupling properties when expressed in mitochondria but that uncoupling by UCP1 or UCP2 does not prevent acute substrate-driven endothelial cell superoxide as effluxed from mitochondria respiring in vitro., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1MTU3", "ec_number_list": [], "go_molecular_function": "GO:0036041 long-chain fatty acid binding;GO:0015078 proton transmembrane transporter activity;GO:1901612 cardiolipin binding;GO:0017077 oxidative phosphorylation uncoupler activity;GO:0032555 purine ribonucleotide binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0009409 response to cold;GO:0031667 response to nutrient levels;GO:0009266 response to temperature stimulus;GO:0032870 cellular response to hormone stimulus;GO:0034614 cellular response to reactive oxygen species", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P10861-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12799-1", "uniprot_id": [ { "id": "FIBG_BOVIN", "url": "https://www.uniprot.org/uniprot/P12799", "type": "external" } ], "mass": 50244.0, "length": 444, "protein_name": "Fibrinogen gamma-B chain", "gene_name": "FGG", "organism": "Bovine", "refseq_name": "fibrinogen gamma-B chain isoform 1 precursor", "refseq_ac": [ { "id": "NP_776336", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776336", "type": "external" } ], "gene_names_uniprotkb": "FGG", "gene_names_refseq": "FGG", "protein_names_uniprotkb": "Fibrinogen gamma-B chain; Gamma'", "protein_names_refseq": "fibrinogen gamma-B chain isoform 1 precursor; fibrinogen gamma-B chain; fibrinogen, gamma polypeptide; gamma'", "tax_id": 9913, "disease": "", "pathway": " (bta:280792)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10618375;11593005;11946783;1942070;2771651;836881", "class_list": "", "function": "Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005577 fibrinogen complex", "go_biological_process": "GO:0007160 cell-matrix adhesion;GO:0070527 platelet aggregation;GO:0051258 protein polymerization", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P12799-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13752-1", "uniprot_id": [ { "id": "HA1A_BOVIN", "url": "https://www.uniprot.org/uniprot/P13752", "type": "external" } ], "mass": 40363.0, "length": 360, "protein_name": "BOLA class I histocompatibility antigen, alpha chain BL3-6", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "BOLA class I histocompatibility antigen, alpha chain BL3-6", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "3133413", "class_list": "", "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030881 beta-2-microglobulin binding;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane;GO:0030670 phagocytic vesicle membrane;GO:0042612 MHC class I protein complex;GO:0098553 lumenal side of endoplasmic reticulum membrane", "go_biological_process": "GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0006955 immune response;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0001916 positive regulation of T cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P13752-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13753-1", "uniprot_id": [ { "id": "HA1B_BOVIN", "url": "https://www.uniprot.org/uniprot/P13753", "type": "external" } ], "mass": 41513.0, "length": 364, "protein_name": "BOLA class I histocompatibility antigen, alpha chain BL3-7", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "BOLA class I histocompatibility antigen, alpha chain BL3-7", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "3133413", "class_list": "", "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030881 beta-2-microglobulin binding;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane;GO:0030670 phagocytic vesicle membrane;GO:0042612 MHC class I protein complex;GO:0098553 lumenal side of endoplasmic reticulum membrane", "go_biological_process": "GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0006955 immune response;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0001916 positive regulation of T cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P13753-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15103-1", "uniprot_id": [ { "id": "GLNA_BOVIN", "url": "https://www.uniprot.org/uniprot/P15103", "type": "external" } ], "mass": 42031.0, "length": 373, "protein_name": "Glutamine synthetase", "gene_name": "GLUL", "organism": "Bovine", "refseq_name": "glutamine synthetase", "refseq_ac": [ { "id": "NP_001035564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035564", "type": "external" } ], "gene_names_uniprotkb": "GLUL", "gene_names_refseq": "GLUL", "protein_names_uniprotkb": "Glutamine synthetase; 2.3.1.225; 6.3.1.2; GS; Glutamate--ammonia ligase; Palmitoyltransferase GLUL", "protein_names_refseq": "GS; glutamate decarboxylase; glutamate-ammonia ligase (glutamine synthase); glutamine synthetase; palmitoyltransferase GLUL", "tax_id": 9913, "disease": "", "pathway": " (bta:281199); (R-BTA-210455); (R-BTA-8964539)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "26440349;2893372;36289327;9321487", "class_list": "", "function": "Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine. Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia. Plays a key role in ammonium detoxification during erythropoiesis: the glutamine synthetase activity is required to remove ammonium generated by porphobilinogen deaminase (HMBS) during heme biosynthesis to prevent ammonium accumulation and oxidative stress (By similarity). Essential for proliferation of fetal skin fibroblasts (By similarity). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development (By similarity). Involved in angiogenesis by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ. Plays a role in ribosomal 40S subunit biogenesis. Through the interaction with BEST2, inhibits BEST2 channel activity by affecting the gating at the aperture in the absence of intracellular L-glutamate, but sensitizes BEST2 to intracellular L-glutamate, which promotes the opening of BEST2 and thus relieves its inhibitory effect on BEST2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; This study concludes that hepatic expression of alanine transaminase and glutathione synthetase (GS) are reduced in aged cows, and administration of 17beta-estradiol increases plasma estradiol and hepatic GS., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O02850;Q3ZBU6;Q866Q7", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0004356 glutamine synthetase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0045648 positive regulation of erythrocyte differentiation;GO:0097275 intracellular ammonium homeostasis;GO:1903670 regulation of sprouting angiogenesis;GO:0006542 glutamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P15103-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15497-1", "uniprot_id": [ { "id": "APOA1_BOVIN", "url": "https://www.uniprot.org/uniprot/P15497", "type": "external" } ], "mass": 30276.0, "length": 265, "protein_name": "Apolipoprotein A-I", "gene_name": "APOA1", "organism": "Bovine", "refseq_name": "apolipoprotein A-I preproprotein", "refseq_ac": [ { "id": "NP_776667", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776667", "type": "external" } ], "gene_names_uniprotkb": "APOA1", "gene_names_refseq": "APOA1", "protein_names_uniprotkb": "Apolipoprotein A-I; Apo-AI; ApoA-I; Apolipoprotein A1", "protein_names_refseq": "apo-AI; apoA-I; apolipoprotein A-I preproprotein", "tax_id": 9913, "disease": "", "pathway": " (bta:281631); (R-BTA-114608); (R-BTA-3000471); (R-BTA-381426); (R-BTA-8957275); (R-BTA-8963888); (R-BTA-8963896); (R-BTA-8963901); (R-BTA-8964011); (R-BTA-8964058); (R-BTA-9707616); (R-BTA-975634)", "pathway_count": 12, "publication_count": 7, "publication_id_list": "11801660;1739745;2105728;2117227;21209084;30573663;33127092", "class_list": "", "function": "Effect of functional single nucleotide polymorphism g.-572 A > G of apolipoprotein A1 gene on resistance to ketosis in Chinese Holstein cows., [RefSeq, PubMed]; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility., [UniProtKB]; The model of a two-step process for the transendothelial transport of apoA-I in which apoA-I is initially lipidated by ABCA1 and then further processed by ABCA1-independent mechanisms., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D7M9;Q3SZD9", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0042803 protein homodimerization activity;GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity;GO:0120020 cholesterol transfer activity", "go_cellular_component": "GO:0034364 high-density lipoprotein particle;GO:0034361 very-low-density lipoprotein particle;GO:0042627 chylomicron;GO:0034362 low-density lipoprotein particle;GO:1903561 extracellular vesicle", "go_biological_process": "GO:0008203 cholesterol metabolic process;GO:0010875 positive regulation of cholesterol efflux;GO:0033700 phospholipid efflux;GO:0042157 lipoprotein metabolic process;GO:0033344 cholesterol efflux", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P15497-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15696-1", "uniprot_id": [ { "id": "IFNT1_BOVIN", "url": "https://www.uniprot.org/uniprot/P15696", "type": "external" } ], "mass": 22134.0, "length": 195, "protein_name": "Interferon tau-1", "gene_name": "IFNT1", "organism": "Bovine", "refseq_name": "interferon tau-2 precursor", "refseq_ac": [ { "id": "NP_001015511", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015511", "type": "external" } ], "gene_names_uniprotkb": "IFNT1", "gene_names_refseq": "IFN-tau-c2; IFNT1; IFNT2; IFNT; TP-1", "protein_names_uniprotkb": "Interferon tau-1; Antiluteolysin; IFN-tau-1; TP-1; Trophoblast antiluteolytic protein; Trophoblast protein 1; Trophoblastin", "protein_names_refseq": "IFN-tau-1; IFN-tau-2; IFN-tau1; IFN-tau2; antiluteolysin; interferon alpha II; interferon tau-1; interferon tau-2 precursor; interferon tau-2; interferon, trophoblast; interferon-tau1e; interferon-tau3e; trophoblast antiluteolytic protein; trophoblast protein-1; trophoblast type I interferon; trophoblastin", "tax_id": 9913, "disease": "", "pathway": " (bta:317698)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "1704373;2378676;2521687;33631711;33690863;33765557;33862433;35907379;8746786;9865498", "class_list": "", "function": "Heat stress influences the attenuation of prostaglandin synthesis by interferon tau in bovine endometrial cells., [RefSeq, PubMed]; JAK3 and PI3K mediates the suppressive effects of interferon tau on neutrophil extracellular traps formation during peri-implantation period., [RefSeq, PubMed]; Neutrophils recognize and amplify IFNT signals derived from day 7 bovine embryo for stimulation of ISGs expression in vitro: A possible implication for the early maternal recognition of pregnancy., [RefSeq, PubMed]; Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible., [UniProtKB]; Pregnancy-induced changes in the transcriptome of the bovine corpus luteum during and after embryonic interferon-tau secretiondagger., [RefSeq, PubMed]; Specific activation of embryonic IFNAR1 and endometrial IFNAR2 induced by embryonic IFNtau directs normal uterine fate for bovine early implantation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P15694;Q28126;Q28127;Q28128;Q28191;Q95NE2", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0007565 female pregnancy;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P15696-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16368-1", "uniprot_id": [ { "id": "TIMP2_BOVIN", "url": "https://www.uniprot.org/uniprot/P16368", "type": "external" } ], "mass": 24355.0, "length": 220, "protein_name": "Metalloproteinase inhibitor 2", "gene_name": "TIMP2", "organism": "Bovine", "refseq_name": "metalloproteinase inhibitor 2 precursor", "refseq_ac": [ { "id": "NP_776897", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776897", "type": "external" } ], "gene_names_uniprotkb": "TIMP2", "gene_names_refseq": "TIMP2", "protein_names_uniprotkb": "Metalloproteinase inhibitor 2; Collagenase inhibitor; TIMP-2; Tissue inhibitor of metalloproteinases 2", "protein_names_refseq": "TIMP-2; collagenase inhibitor; metalloproteinase inhibitor 2 precursor; metalloproteinase inhibitor 2; tissue inhibitor of metalloproteinases 2; tissue inhibitor of mettaloproteinase 2", "tax_id": 9913, "disease": "", "pathway": " (bta:282093)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "17196980;20887771;21247626;2157214;21626345;23266860;2551903;3005321;8424773;9724659", "class_list": "", "function": "A differential pattern of matrix metalloproteinase-2 and Tissue inhibitor metalloproteinase-2 was observed in cow uteri with adenomyosis., [RefSeq, PubMed]; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor., [UniProtKB]; Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 expression by NF-kappaB-MT1-MMP-dependent and -independent pathway., [RefSeq, PubMed]; MMP-14, MMP-2 and TIMP-2 are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle., [RefSeq, PubMed]; Results describe distinct changes in expression of MMP2, MMP14, and the metallopeptidase inhibitor TIMP2 between different phases of the estrous cycle indicating an endocrine regulation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZU3;Q9TVB1", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:0034097 response to cytokine;GO:0009725 response to hormone", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P16368-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17289-1", "uniprot_id": [ { "id": "TY3H_BOVIN", "url": "https://www.uniprot.org/uniprot/P17289", "type": "external" } ], "mass": 55123.0, "length": 491, "protein_name": "Tyrosine 3-monooxygenase", "gene_name": "TH", "organism": "Bovine", "refseq_name": "tyrosine 3-monooxygenase", "refseq_ac": [ { "id": "NP_776309", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776309", "type": "external" } ], "gene_names_uniprotkb": "TH", "gene_names_refseq": "TH", "protein_names_uniprotkb": "Tyrosine 3-monooxygenase; 1.14.16.2; TH; Tyrosine 3-hydroxylase", "protein_names_refseq": "tyrosine 3-hydroxylase; tyrosine 3-monooxygenase", "tax_id": 9913, "disease": "", "pathway": " (bta:280707)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "12558965;17261361;17908239;19207826;1970788;26825549;2894860;2895648;2898537;2899135;8096628", "class_list": "", "function": "Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (By similarity). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; IFN-alpha mediated activation of ERK1/2 appeared to be responsible for the increased phosphorylation of tyrosine hydroxylase., [RefSeq, PubMed]; Retinol activates tyrosine hydroxylase via two sequential non-genomic mechanisms, which have not previously been characterized. These mechanisms are likely to operate in vivo to facilitate the stress response., [RefSeq, PubMed]; TH is a robust interaction partner of different 14-3-3 dimer types with moderate variability between the 14-3-3 dimers on their regulation of TH., [RefSeq, PubMed]; The sustained activation of TH that occurred as a result of TH phosphorylation at Ser40 could maintain the synthesis of catecholamines without the need for further stimulus of the adrenal cells or increased TH protein synthesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.16.2", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0004511 tyrosine 3-monooxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030424 axon;GO:0043204 perikaryon;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1990384 hyaloid vascular plexus regression;GO:0006585 dopamine biosynthetic process from tyrosine;GO:0007617 mating behavior;GO:0050890 cognition;GO:0001963 synaptic transmission, dopaminergic", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P17289-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17404-1", "uniprot_id": [ { "id": "CNMD_BOVIN", "url": "https://www.uniprot.org/uniprot/P17404", "type": "external" } ], "mass": 37164.0, "length": 335, "protein_name": "Leukocyte cell-derived chemotaxin 1", "gene_name": "CNMD", "organism": "Bovine", "refseq_name": "leukocyte cell-derived chemotaxin 1 precursor", "refseq_ac": [ { "id": "NP_776694", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776694", "type": "external" } ], "gene_names_uniprotkb": "CNMD; CHMI; LECT1", "gene_names_refseq": "CHM-I; CNMD; LECT1", "protein_names_uniprotkb": "Leukocyte cell-derived chemotaxin 1; ChM-I; Chondromodulin-I; Chondromodulin; SCGP; Small cartilage-derived glycoprotein", "protein_names_refseq": "SCGP; chondromodulin I; chondromodulin-1; leukocyte cell derived chemotaxin 1; leukocyte cell-derived chemotaxin 1 precursor; small cartilage-derived glycoprotein", "tax_id": 9913, "disease": "", "pathway": " (bta:281683)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "10912526;11323410;1709014;2351661", "class_list": "", "function": "Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 1, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "P23590", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0012505 endomembrane system", "go_biological_process": "GO:0030154 cell differentiation;GO:0001937 negative regulation of endothelial cell proliferation;GO:0016525 negative regulation of angiogenesis;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P17404-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1100000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18246-1", "uniprot_id": [ { "id": "CXA1_BOVIN", "url": "https://www.uniprot.org/uniprot/P18246", "type": "external" } ], "mass": 43188.0, "length": 383, "protein_name": "Gap junction alpha-1 protein", "gene_name": "GJA1", "organism": "Bovine", "refseq_name": "gap junction alpha-1 protein", "refseq_ac": [ { "id": "NP_776493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776493", "type": "external" } ], "gene_names_uniprotkb": "GJA1", "gene_names_refseq": "CXNK1; GJA1", "protein_names_uniprotkb": "Gap junction alpha-1 protein; Connexin-43; Cx43; Vascular smooth muscle connexin-43", "protein_names_refseq": "connexin K1; connexin-43; cx43; gap junction alpha-1 protein; gap junction protein, alpha 1, 43 kD (connexin 43); gap junction protein, alpha 1, 43kDa; vascular smooth muscle connexin-43", "tax_id": 9913, "disease": "", "pathway": " (bta:281193); (R-BTA-190840); (R-BTA-190861); (R-BTA-190873); (R-BTA-191650); (R-BTA-196025); (R-BTA-9013406)", "pathway_count": 7, "publication_count": 10, "publication_id_list": "11824477;15123628;15319221;16310041;1695901;24210276;27760016;31544318;33159276;33672423", "class_list": "", "function": "BPA and BPS Affect Connexin 37 in Bovine Cumulus Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Cumulus-oocyte complexes and granulosa cells exposed to ATRA during maturation had significantly higher CX43 expression and increased gap junctional coupling, respectively., [RefSeq, PubMed]; Cx43 mRNA and protein expression increased after endothelial cell exposure to ketone bodies; this was accompanied by upregulation of gap junctional intercellular coupling and cell migration., [RefSeq, PubMed]; Expression in the rumen epithelium., [RefSeq, PubMed]; Human TGF-beta1 induces an accumulation of connexin43 in a lysosomal compartment in bovine endothelial cells, [RefSeq, PubMed]; Increased degradation of Cx43 and reduction of intracellular communication through gap junctions in high glucose may be of physiological importance by contributing to endothelial cell dysfunction., [RefSeq, PubMed]; Intermediate invasive status of bovine trophoblast is supported by the fact that trophoblast giant cells coexpress connexins (Cx)26, Cx32, and Cx43, [RefSeq, PubMed]; Preservation of connexin 43 and transzonal projections in isolated bovine pre-antral follicles before and following vitrification. Erratum:[J Assist Reprod Genet. 2021 Feb;38(2):493. doi: 10.1007/s10815-020-02040-w. PMID: 33331983], [RefSeq, PubMed]; Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage (By similarity). May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph (By similarity). Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in the conductive system of ventricular myocardium and heart morphogenesis. May play a role in cell growth inhibition through the regulation of NOV expression and localization (By similarity). Involved in intercellular innate immune signaling. Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This study found that down-regulation of Cx43 expression in the junction zone might play an important role in pathogenesis of adenomyosis, and that estradiol modulates gap junctions during adenomyosis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2KJ91", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0030165 PDZ domain binding;GO:0008013 beta-catenin binding;GO:0015631 tubulin binding;GO:0055077 gap junction hemi-channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0043403 skeletal muscle tissue regeneration;GO:2000648 positive regulation of stem cell proliferation;GO:0001701 in utero embryonic development;GO:0007165 signal transduction;GO:0007267 cell-cell signaling", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P18246-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18341-1", "uniprot_id": [ { "id": "TGFB1_BOVIN", "url": "https://www.uniprot.org/uniprot/P18341", "type": "external" } ], "mass": 44409.0, "length": 390, "protein_name": "Transforming growth factor beta-1 proprotein", "gene_name": "TGFB1", "organism": "Bovine", "refseq_name": "transforming growth factor beta-1 proprotein precursor", "refseq_ac": [ { "id": "NP_001159540", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159540", "type": "external" } ], "gene_names_uniprotkb": "TGFB1", "gene_names_refseq": "TGFB1", "protein_names_uniprotkb": "Transforming growth factor beta-1 proprotein", "protein_names_refseq": "TGF-beta-1; transforming growth factor beta-1 proprotein precursor; transforming growth factor beta-1 proprotein; transforming growth factor, beta 1 (Camurati-Engelmann disease)", "tax_id": 9913, "disease": "", "pathway": " (bta:282089)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12441094;12591230;14502602;1733936;28019669;28578597;29228113;3153459;31967968", "class_list": "", "function": "Data show that as antral follicles develop, transforming growth factor (TGF)-beta3 is the most abundant TGF-beta isoform and TGF-beta1 protein levels decline in large follicles., [RefSeq, PubMed]; Immunohistochemistry in rectus abdominis muscle from foetuses at 180 and 260 days post-conception, [RefSeq, PubMed]; Modulatory effects of TGF-beta1 and BMP6 on thecal angiogenesis and steroidogenesis in the bovine ovary., [RefSeq, PubMed]; Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains remain non-covalently linked rendering TGF-beta-1 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS that control activation of TGF-beta-1 and maintain it in a latent state during storage in extracellular milieus. TGF-beta-1 is released from LAP by integrins (ITGAV:ITGB6 or ITGAV:ITGB8): integrin-binding to LAP stabilizes an alternative conformation of the LAP bowtie tail and results in distortion of the LAP chain and subsequent release of the active TGF-beta-1. Once activated following release of LAP, TGF-beta-1 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity). While expressed by many cells types, TGF-beta-1 only has a very localized range of action within cell environment thanks to fine regulation of its activation by Latency-associated peptide chain (LAP) and 'milieu molecules'. Plays an important role in bone remodeling: acts as a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP). Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Positively regulates odontoblastic differentiation in dental papilla cells, via promotion of IPO7-mediated translocation of phosphorylated SMAD2 to the nucleus and subsequent transcription of target genes (By similarity). Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1. Interaction with LRRC33/NRROS regulates activation of TGF-beta-1 in macrophages and microglia. Interaction with LRRC32/GARP controls activation of TGF-beta-1 on the surface of activated regulatory T-cells (Tregs). Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1., [UniProtKB, UniProtKB]; TGF-beta1 modulates the expression of syndecan-4 in cultured vascular endothelial cells in a biphasic manner., [RefSeq, PubMed]; TGF-beta1 stimulated lubricin secretion by superficial zone chondrocytes at all densities with twice-a-week TGF-beta treatment. It is noteworthy that the daily treatment of TGF-beta1 increased lubricin much higher compared with twice-a-week treatment., [RefSeq, PubMed]; These data support the contention that FGF2 and TGFB1 modulate THBS1 via miR-221., [RefSeq, PubMed]; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively., [UniProtKB, UniProtKB]; Vascular endothelial growth factor indirectly stimulates smooth muscle cell proliferation and migration through the modulation of basic fibroblast growth factor and transforming growth factor beta(1) released by endothelial cells, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A5A3B8", "ec_number_list": [], "go_molecular_function": "GO:0034714 type III transforming growth factor beta receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0005114 type II transforming growth factor beta receptor binding;GO:0034713 type I transforming growth factor beta receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0031012 extracellular matrix", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0016202 regulation of striated muscle tissue development;GO:0085029 extracellular matrix assembly;GO:0032740 positive regulation of interleukin-17 production;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P18341-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18493-1", "uniprot_id": [ { "id": "PARP1_BOVIN", "url": "https://www.uniprot.org/uniprot/P18493", "type": "external" } ], "mass": 113486.0, "length": 1016, "protein_name": "Poly [ADP-ribose] polymerase 1", "gene_name": "PARP1", "organism": "Bovine", "refseq_name": "poly [ADP-ribose] polymerase 1", "refseq_ac": [ { "id": "NP_777176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777176", "type": "external" } ], "gene_names_uniprotkb": "PARP1; ADPRT", "gene_names_refseq": "ADPRT; ARTD1; PARP1", "protein_names_uniprotkb": "Poly [ADP-ribose] polymerase 1; 2.4.2.-; 2.4.2.30; ADP-ribosyltransferase diphtheria toxin-like 1; ADPRT 1; ARTD1; DNA ADP-ribosyltransferase PARP1; NAD(+) ADP-ribosyltransferase 1; PARP-1; Poly [ADP-ribose] polymerase 1, 24-kDa form; Poly [ADP-ribose] polymerase 1, 89-kDa form; Poly[ADP-ribose] synthase 1; Protein poly-ADP-ribosyltransferase PARP1", "protein_names_refseq": "ADP-ribosyltransferase (NAD+) poly (ADP-ribose) polymerase); ADP-ribosyltransferase diphtheria toxin-like 1; ADPRT 1; DNA ADP-ribosyltransferase PARP1; NAD(+) ADP-ribosyltransferase 1; PARP-1; poly (ADP-ribose) polymerase family, member 1; poly [ADP-ribose] polymerase 1; poly(ADP-ribose) synthetase; poly[ADP-ribose] synthase 1; poly[ADP-ribose] synthetase 1; protein poly-ADP-ribosyltransferase PARP1", "tax_id": 9913, "disease": "", "pathway": " (bta:286764)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15389540;20514865;2119324;23272074;2450019;26950517;33803196", "class_list": "", "function": "ADPRT Val762Ala and APE1 Asp148Glu polymorphisms are not associated with increased breast cancer risk, [RefSeq, PubMed]; Analysis of poly(ADP-ribose) polymerase 1 interaction with apurinic/apyrimidinic sites, [RefSeq, PubMed]; FGF2 stimulates poly(ADP-ribose) polymerase activity by a DNA strand breaks-independent manner which involves a mitogen-activated protein kinases (MAPK)-dependent pathway, [RefSeq, PubMed]; New Insights into the Significance of PARP-1 Activation: Flow Cytometric Detection of Poly(ADP-Ribose) as a Marker of Bovine Intramammary Infection. Publication Status: Online-Only, [RefSeq, PubMed]; No difference was found in the level of SBDP145 between muscles, while SBDP120 and PARP-1 cleavage products were not detected, [RefSeq, PubMed]; Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (By similarity). Mediates glutamate, aspartate, serine, histidine or tyrosine ADP-ribosylation of proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of target residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (By similarity). Specificity for the different amino acids is conferred by interacting factors, such as HPF1 and NMNAT1 (By similarity). Following interaction with HPF1, catalyzes serine ADP-ribosylation of target proteins; HPF1 confers serine specificity by completing the PARP1 active site. Also catalyzes tyrosine ADP-ribosylation of target proteins following interaction with HPF1 (By similarity). Following interaction with NMNAT1, catalyzes glutamate and aspartate ADP-ribosylation of target proteins; NMNAT1 confers glutamate and aspartate specificity (By similarity). PARP1 initiates the repair of DNA breaks: recognizes and binds DNA breaks within chromatin and recruits HPF1, licensing serine ADP-ribosylation of target proteins, such as histones (H2BS6ADPr and H3S10ADPr), thereby promoting decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks. HPF1 initiates serine ADP-ribosylation but restricts the polymerase activity of PARP1 in order to limit the length of poly-ADP-ribose chains. In addition to base excision repair (BER) pathway, also involved in double-strand breaks (DSBs) repair: together with TIMELESS, accumulates at DNA damage sites and promotes homologous recombination repair by mediating poly-ADP-ribosylation. Mediates the poly-ADP-ribosylation of a number of proteins, including itself, APLF, CHFR and NFAT5. In addition to proteins, also able to ADP-ribosylate DNA: catalyzes ADP-ribosylation of DNA strand break termini containing terminal phosphates and a 2'-OH group in single- and double-stranded DNA, respectively. Required for PARP9 and DTX3L recruitment to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (By similarity). PARP1-mediated DNA repair in neurons plays a role in sleep: senses DNA damage in neurons and promotes sleep, facilitating efficient DNA repair. In addition to DNA repair, also involved in other processes, such as transcription regulation, programmed cell death, membrane repair, adipogenesis and innate immunity (By similarity). Acts as a repressor of transcription: binds to nucleosomes and modulates chromatin structure in a manner similar to histone H1, thereby altering RNA polymerase II. Acts both as a positive and negative regulator of transcription elongation, depending on the context. Acts as a positive regulator of transcription elongation by mediating poly-ADP-ribosylation of NELFE, preventing RNA-binding activity of NELFE and relieving transcription pausing. Acts as a negative regulator of transcription elongation in response to DNA damage by catalyzing poly-ADP-ribosylation of CCNT1, disrupting the phase separation activity of CCNT1 and subsequent activation of CDK9. Involved in replication fork progression following interaction with CARM1: mediates poly-ADP-ribosylation at replication forks, slowing fork progression (By similarity). Poly-ADP-ribose chains generated by PARP1 also play a role in poly-ADP-ribose-dependent cell death, a process named parthanatos. Also acts as a negative regulator of the cGAS-STING pathway. Acts by mediating poly-ADP-ribosylation of CGAS: PARP1 translocates into the cytosol following phosphorylation by PRKDC and catalyzes poly-ADP-ribosylation and inactivation of CGAS. Acts as a negative regulator of adipogenesis: catalyzes poly-ADP-ribosylation of histone H2B on 'Glu-35' (H2BE35ADPr) following interaction with NMNAT1, inhibiting phosphorylation of H2B at 'Ser-36' (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (By similarity). Plays a role in sister chromatid cohesion by mediating ADP-ribosylation of RSMC during S phase which promotes the interaction between RSMC and CDCA5/sororin, leading to enhanced interaction of CDCA5/sororin with the cohesin complex and promotion of sister chromatid cohesion (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Promotes AIFM1-mediated apoptosis. This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis., [UniProtKB, UniProtKB]; This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9TS00", "ec_number_list": [ { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" } ], "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0003684 damaged DNA binding;GO:0051287 NAD binding", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0070213 protein auto-ADP-ribosylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045087 innate immune response;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P18493-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18915-1", "uniprot_id": [ { "id": "CAH6_BOVIN", "url": "https://www.uniprot.org/uniprot/P18915", "type": "external" } ], "mass": 37007.0, "length": 319, "protein_name": "Carbonic anhydrase 6", "gene_name": "CA6", "organism": "Bovine", "refseq_name": "carbonic anhydrase 6 precursor", "refseq_ac": [ { "id": "NP_776323", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776323", "type": "external" } ], "gene_names_uniprotkb": "CA6", "gene_names_refseq": "CA6", "protein_names_uniprotkb": "Carbonic anhydrase 6; 4.2.1.1; CA-VI; Carbonate dehydratase VI; Carbonic anhydrase VI; Salivary carbonic anhydrase; Secreted carbonic anhydrase", "protein_names_refseq": "CA-VI; carbonate dehydratase VI; carbonic anhydrase 6 precursor; carbonic anhydrase VI; salivary carbonic anhydrase; secreted carbonic anhydrase", "tax_id": 9913, "disease": "", "pathway": " (bta:280742)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12547264;2497732;8761494", "class_list": "", "function": "Bovine mammary epithelial cells synthesize and secrete CA VI in colostrum at higher concentration than in normal milk, implying its role to compensate for low CA VI secretion in neonatal calves., [RefSeq, PubMed]; Reversible hydration of carbon dioxide. Its role in saliva is unknown., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q95322", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "4.2.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.69", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P18915-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19217-1", "uniprot_id": [ { "id": "ST1E1_BOVIN", "url": "https://www.uniprot.org/uniprot/P19217", "type": "external" } ], "mass": 34640.0, "length": 295, "protein_name": "Sulfotransferase 1E1", "gene_name": "SULT1E1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SULT1E1; OST; STE", "gene_names_refseq": "", "protein_names_uniprotkb": "Sulfotransferase 1E1; 2.8.2.4; Estrogen sulfotransferase; ST1E1; Sulfotransferase, estrogen-preferring", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "1900200;3270501;3271383", "class_list": "", "function": "Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (By similarity) (PubMed:1900200). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency. Does not sulfonate cortisol, testosterone and dopamine (By similarity). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" }, { "id": "2.8.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.4", "type": "external" }, { "id": "2.8.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.1", "type": "external" } ], "go_molecular_function": "GO:0004304 estrone sulfotransferase activity;GO:0050294 steroid sulfotransferase activity;GO:0004062 aryl sulfotransferase activity;GO:0005496 steroid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0051923 sulfation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P19217-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19534-1", "uniprot_id": [ { "id": "CADH2_BOVIN", "url": "https://www.uniprot.org/uniprot/P19534", "type": "external" } ], "mass": 99807.0, "length": 906, "protein_name": "Cadherin-2", "gene_name": "CDH2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CDH2", "gene_names_refseq": "", "protein_names_uniprotkb": "Cadherin-2; N-cadherin; Neural cadherin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-381426); (R-BTA-418990); (R-BTA-525793); (R-BTA-8957275)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "19393038;2390969", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins., [UniProtKB, UniProtKB, UniProtKB]; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (By similarity). Required for proper neurite branching. Required for pre- and postsynaptic organization (By similarity). CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 9, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "F1N0S5", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding;GO:0003723 RNA binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0009986 cell surface", "go_biological_process": "GO:0097091 synaptic vesicle clustering;GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0098609 cell-cell adhesion;GO:0007416 synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P19534-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20237-1", "uniprot_id": [ { "id": "GBRA4_BOVIN", "url": "https://www.uniprot.org/uniprot/P20237", "type": "external" } ], "mass": 61547.0, "length": 555, "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-4", "gene_name": "GABRA4", "organism": "Bovine", "refseq_name": "gamma-aminobutyric acid receptor subunit alpha-4 precursor", "refseq_ac": [ { "id": "NP_776968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776968", "type": "external" } ], "gene_names_uniprotkb": "GABRA4", "gene_names_refseq": "GABRA4", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit alpha-4; GABA(A) receptor subunit alpha-4; GABAAR subunit alpha-4", "protein_names_refseq": "GABA(A) receptor subunit alpha-4; GABAAR subunit alpha-4; gamma-aminobutyric acid (GABA) A receptor, alpha 4; gamma-aminobutyric acid receptor subunit alpha-4 precursor; gamma-aminobutyric acid receptor subunit alpha-4; gamma-aminobutyric acid type A receptor alpha4 subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:282238); (R-BTA-977443)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "2556293", "class_list": "", "function": "Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:2556293). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:2556293). GABAARs containing alpha-4 are predominantly extrasynaptic, contributing to tonic inhibition in dentate granule cells and thalamic relay neurons (By similarity). Extrasynaptic alpha-4-containing GABAARs control levels of excitability and network activity (By similarity). GABAARs containing alpha-4 are often found with the delta or gamma-2 subunits, in combination with beta subunits (By similarity). GABAAR containing alpha-4-beta-3-delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q08E47", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0098794 postsynapse;GO:0034707 chloride channel complex;GO:0032590 dendrite membrane;GO:1902711 GABA-A receptor complex", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P20237-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true } ]