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        ],
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        "protein_name": "Replication factor C subunit 1",
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        "gene_names_uniprotkb": "rfc1; si:dkey-170e5.1; zgc:162875",
        "gene_names_refseq": "rfc1; si:dkey-170e5.1; zgc:162875",
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        "disease": "cerebellar ataxia, neuropathy, and vestibular areflexia syndrome (Disease Ontology:DOID:0070148); congenital heart disease (Disease Ontology:DOID:1682); West Nile fever (Disease Ontology:DOID:2366)",
        "pathway": " (dre:100037336);  (R-DRE-110312);  (R-DRE-110314);  (R-DRE-110320);  (R-DRE-5651801);  (R-DRE-5655862);  (R-DRE-5656121);  (R-DRE-5656169);  (R-DRE-5685942);  (R-DRE-5693537);  (R-DRE-5696397);  (R-DRE-5696400);  (R-DRE-6782135);  (R-DRE-6782210);  (R-DRE-69091)",
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        "function": "##Genome-Annotation-Data-START## Annotation Provider         :: NCBI RefSeq Annotation Status           :: Full annotation Annotation Name             :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated          :: Gene; mRNA; CDS; ncRNA Annotation Date             :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ:  This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Can bind single- or double-stranded DNA., [UniProtKB, UniProtKB, UniProtKB]",
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        "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588732.29202224.1, SRR32588722.47661717.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000003.1. On Aug 11, 2025 this sequence version replaced XP_073801032.1., [RefSeq]",
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                "id": "1.14.14.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1",
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            },
            {
                "id": "4.2.1.152",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.152",
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            },
            {
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                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.5",
                "type": "external"
            }
        ],
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        "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane",
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        "length": 898,
        "protein_name": "Zinc finger protein 281",
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            {
                "id": "XP_073800925",
                "url": "https://www.ncbi.nlm.nih.gov/protein/XP_073800925",
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        "function": "##Genome-Annotation-Data-START## Annotation Provider         :: NCBI RefSeq Annotation Status           :: Full annotation Annotation Name             :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated          :: Gene; mRNA; CDS; ncRNA Annotation Date             :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ:  This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs. Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
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        "go_cellular_component": "GO:0005634 nucleus",
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        "gene_names_refseq": "LOC141381262",
        "protein_names_uniprotkb": "Uncharacterized protein isoform X2",
        "protein_names_refseq": "uncharacterized protein isoform X2",
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        "function": "##Genome-Annotation-Data-START## Annotation Provider         :: NCBI RefSeq Annotation Status           :: Full annotation Annotation Name             :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated          :: Gene; mRNA; CDS; ncRNA Annotation Date             :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ:  This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]",
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        "length": 571,
        "protein_name": "LOW QUALITY PROTEIN: uncharacterized protein il4r.2",
        "gene_name": "il4r.2",
        "organism": "Zebrafish",
        "refseq_name": "LOW QUALITY PROTEIN: uncharacterized protein il4r.2",
        "refseq_ac": [
            {
                "id": "XP_073801044",
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        "protein_names_uniprotkb": "LOW QUALITY PROTEIN: uncharacterized protein il4r.2",
        "protein_names_refseq": "LOW QUALITY PROTEIN: uncharacterized protein il4r.2",
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        "function": "##Genome-Annotation-Data-START## Annotation Provider         :: NCBI RefSeq Annotation Status           :: Full annotation Annotation Name             :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated          :: Gene; mRNA; CDS; ncRNA Annotation Date             :: 04/11/2025 ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## internal stop codons        :: corrected 1 genomic stop codon ##RefSeq-Attributes-END## MODEL REFSEQ:  This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]",
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        "refseq_ac": [
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        "function": "##Genome-Annotation-Data-START## Annotation Provider         :: NCBI RefSeq Annotation Status           :: Full annotation Annotation Name             :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated          :: Gene; mRNA; CDS; ncRNA Annotation Date             :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ:  This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits., [UniProtKB, UniProtKB]",
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        "protein_names_refseq": "tubulin-specific chaperone D",
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        "function": "##Genome-Annotation-Data-START## Annotation Provider         :: NCBI RefSeq Annotation Status           :: Full annotation Annotation Name             :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated          :: Gene; mRNA; CDS; ncRNA Annotation Date             :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ:  This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis. Involved in neuron morphogenesis., [UniProtKB, UniProtKB]",
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        "function": "##Genome-Annotation-Data-START## Annotation Provider         :: NCBI RefSeq Annotation Status           :: Full annotation Annotation Name             :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated          :: Gene; mRNA; CDS; ncRNA Annotation Date             :: 04/11/2025 ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio                   :: 44% of CDS bases ##RefSeq-Attributes-END## MODEL REFSEQ:  This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133178) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]",
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        "function": "##Genome-Annotation-Data-START## Annotation Provider         :: NCBI RefSeq Annotation Status           :: Full annotation Annotation Name             :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated          :: Gene; mRNA; CDS; ncRNA Annotation Date             :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ:  This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133179) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures. Functions in dorsal root ganglion neurons., [UniProtKB, UniProtKB, UniProtKB]; Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Binding of the excitatory neurotransmitter L-glutamate induces a conformational change leading to the opening of the cation channel, converting the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist., [UniProtKB, UniProtKB, UniProtKB]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB]",
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        "function": "##Genome-Annotation-Data-START## Annotation Provider         :: NCBI RefSeq Annotation Status           :: Full annotation Annotation Name             :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated          :: Gene; mRNA; CDS; ncRNA Annotation Date             :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ:  This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
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        "function": "##Genome-Annotation-Data-START## Annotation Provider         :: NCBI RefSeq Annotation Status           :: Full annotation Annotation Name             :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated          :: Gene; mRNA; CDS; ncRNA Annotation Date             :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ:  This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]",
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        "protein_name": "Ankyrin-1",
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        "disease": "hereditary spherocytosis type 1 (Disease Ontology:DOID:0110916); malaria (Disease Ontology:DOID:12365); hereditary spherocytosis (Disease Ontology:DOID:12971); transient cerebral ischemia (Disease Ontology:DOID:224); anemia (Disease Ontology:DOID:2355)",
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        "protein_name": "Ras-like protein family member 10A isoform X1",
        "gene_name": "rasl10a",
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        "refseq_ac": [
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                "id": "XP_073805673",
                "url": "https://www.ncbi.nlm.nih.gov/protein/XP_073805673",
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        ],
        "gene_names_uniprotkb": "rasl10a; si:dkey-253g8.1",
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        ],
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        ],
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        ],
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        "protein_name": "Macrophage-capping protein",
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        "go_biological_process": "GO:0007417 central nervous system development;GO:0051016 barbed-end actin filament capping;GO:0008154 actin polymerization or depolymerization;GO:0051014 actin filament severing;GO:0030031 cell projection assembly",
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        "protein_names_uniprotkb": "Pyruvate dehydrogenase E1 component subunit alpha; 1.2.4.1",
        "protein_names_refseq": "pyruvate dehydrogenase (lipoamide) alpha 1a; pyruvate dehydrogenase (lipoamide) alpha 1; pyruvate dehydrogenase E1 alpha 1 subunit a; pyruvate dehydrogenase E1 subunit alpha 1a isoform 1",
        "tax_id": 7955,
        "disease": "pyruvate decarboxylase deficiency (Disease Ontology:DOID:3649)",
        "pathway": " (R-DRE-204174);  (R-DRE-5362517);  (R-DRE-9837999);  (R-DRE-9861559)",
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        "function": "##Evidence-Data-START## Transcript exon combination :: SRR32588725.10361032.1, SRR32588719.14137706.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Aug 12, 2025 this sequence version replaced XP_073806209.1. Publication Note:  This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Together with PDHB forms the heterotetrameric E1 subunit of the pyruvate dehydrogenase (PDH) complex in testis. The PDH complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). The E1 subunit catalyzes both the thiamine pyrophosphate (TPP)-dependent decarboxylation of pyruvate and the reductive acetylation of a lipoyl group covalently linked to the lipoyl-bearing domains of E2., [UniProtKB, UniProtKB]",
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            {
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        ],
        "mass": 38450.0,
        "length": 331,
        "protein_name": "Cyclin-H",
        "gene_name": "ccnh",
        "organism": "Zebrafish",
        "refseq_name": "cyclin-H isoform 2",
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            {
                "id": "NP_001428803",
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        ],
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        "gene_names_refseq": "ccnh; zgc:114132",
        "protein_names_uniprotkb": "Cyclin-H",
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        "function": "##Evidence-Data-START## Transcript exon combination :: SRR26395028.1027376.1, SRR26395050.618579.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA3505370, SAMEA3505371 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JBMGRA010000005.1. On Jul 8, 2025 this sequence version replaced XP_073806420.1. Publication Note:  This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Cyclin H is implicated in the regulation of the transcriptional machinery during midblastula transition and is therefore an essential gene in early zebrafish larval development., [RefSeq, PubMed]; Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle., [UniProtKB, UniProtKB, UniProtKB]",
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        "function": "##Genome-Annotation-Data-START## Annotation Provider         :: NCBI RefSeq Annotation Status           :: Full annotation Annotation Name             :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated          :: Gene; mRNA; CDS; ncRNA Annotation Date             :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ:  This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133180) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]",
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        "function": "##Genome-Annotation-Data-START## Annotation Provider         :: NCBI RefSeq Annotation Status           :: Full annotation Annotation Name             :: GCF_049306965.1-RS_2025_04 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.3 Annotation Method :: Best-placed RefSeq; Gnomon; cmsearch; tRNAscan-SE Features Annotated          :: Gene; mRNA; CDS; ncRNA Annotation Date             :: 04/11/2025 ##Genome-Annotation-Data-END## MODEL REFSEQ:  This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_133176) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]",
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        "gene_name": "ganaba",
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